Hub : Genes

UBQLN4P1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.175	0.073	0.0088	-0.004	NA	-0.007	NA	0.007	0.4600	NA	0.700	NA	0.17000
2	GTEx	Uterus	0.342	0.117	0.0080	0.127	NA	0.051	NA	0.153	0.0015	NA	0.034	NA	0.00052
3	GTEx	Whole Blood	0.100	0.037	0.0021	-0.003	NA	-0.001	NA	-0.002	0.9600	NA	0.360	NA	0.68000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.3	3.8	-0.2	0.4	1.9
Bipolar Disorder or Schizophrenia	1.6	4.0	9.3	1.5	0.7	3.1
Depressed Affect (Nagel 2018)	0.8	1.8	4.6	2.2	-0.6	-0.6
Depression (Nagel 2018)	0.2	0.3	0.8	0.9	0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	0.4	-0.1	-0.7
Neuroticism (Nagel 2018)	0.4	0.9	2.2	1.5	-0.2	-0.6
Schizophrenia (2018)	1.6	3.4	5.4	2.1	0.6	2.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.3	-0.4	-0.2
Worry (Nagel 2018)	0.3	0.6	1.0	1.0	-0.9	0.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	0.3	-0.8	-0.6
Alzheimer’s Disease (in father)	1.5	1.7	3.1	-1.3	-1.8	-0.1
Alzheimer’s Disease (including proxy)	0.6	0.8	1.9	-1.4	-0.7	-0.0
Crohns Disease (2017)	0.5	1.0	1.7	1.3	0.3	-1.1
Irritable Bowel Disease (IBD)	0.2	0.6	1.3	0.6	0.1	-1.1
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.0	-0.5	-0.5
Major Depression (MDD)	1.9	2.3	6.0	0.8	-2.5	0.6
Reaction Time	2.8	5.4	10.6	-1.5	1.8	-3.3
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.5	0.5	-0.4	-1.2
Breast Cancer	0.4	0.9	1.7	-0.4	1.3	1.0
Ovarian Cancer	0.5	0.7	1.4	0.8	0.1	1.2
Prostate Cancer	0.4	0.5	1.0	0.7	-0.2	1.0
Age at First Birth	0.1	0.1	0.3	-0.6	0.0	0.3
Bipolar Disorder (2011)	1.2	1.2	2.6	-0.2	1.0	1.6
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.2	-0.3	-0.4
Coronary Artery Disease (CAD)	1.7	2.0	4.2	-1.3	0.4	-2.0
Crohns Disease (2012)	0.2	0.4	0.9	1.0	0.3	0.4
Mean Putamen Volume	0.3	0.4	1.0	-1.0	0.1	0.2
Fasting Glucose	1.7	2.0	4.9	2.2	0.8	0.6
HbA1C	1.5	1.7	2.2	1.5	-1.4	1.0
HDL Cholesterol	1.5	2.4	6.2	0.3	-2.5	1.0
LDL Cholesterol	0.8	1.2	3.1	-1.8	0.2	-0.7
Lupus	0.3	0.4	0.6	-0.8	-0.4	0.6
Neuroticism (2016)	1.3	1.9	4.4	-1.0	-2.1	-0.4
Primary Biliary Cirrhosis	0.9	1.3	2.6	1.0	0.4	1.6
Rheumatoid Arthritis	0.2	0.2	0.4	-0.5	0.0	0.6
Schizophrenia (2014)	1.1	2.5	5.2	1.4	-0.2	2.3
Triglycerides	1.7	2.8	3.6	-1.3	1.8	-1.9
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.1	-0.2	-0.5
Ulcerative Colitis	0.0	0.0	0.1	0.1	-0.1	0.3
Blood Eosinophil Count	0.6	4.8	13.1	-0.6	3.6	0.9
Blood Platelet Count	0.3	3.8	5.1	-2.3	2.1	1.3
Blood Red Count	0.3	3.4	4.1	-2.0	1.6	-1.9
Blood White Count	0.6	4.4	13.0	0.1	3.6	0.2
Heel T-Score	0.4	3.2	5.1	2.0	-0.8	2.2
BMI	1.6	9.4	12.4	-2.7	2.9	-3.5
Height	0.5	9.4	26.5	-1.3	-5.2	0.3
Waist Hip Ratio (WHR)	0.0	0.1	0.1	0.1	-0.3	-0.4
Systolic Blood Pressure	0.2	1.0	2.9	-0.3	-0.3	-1.7
Smoking Status	0.1	0.3	0.7	-0.0	0.9	0.2
Allergy or Eczema	0.3	0.9	1.5	1.0	0.5	-1.2
Cardiovascular Disease	1.0	3.3	8.2	-1.1	0.7	-2.9
Hypothyroidism (self reported)	0.2	0.4	0.9	0.5	1.0	0.4
Respiratory disease	0.1	0.3	0.5	-0.4	0.7	-0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	1.1	0.7	-0.5
Lung FEV1/FVC ratio	0.2	0.9	1.3	1.1	0.7	1.0
Lung FVC	0.3	1.7	3.3	0.9	-0.9	1.8
Neuroticism	0.7	1.8	3.0	1.4	-1.7	-0.5
Chronotype (morning person)	0.4	0.9	2.5	0.1	-0.1	-1.6
Hair Pigment	0.1	3.2	6.9	0.9	-2.6	1.4
Tanning	0.1	1.5	2.6	1.6	0.0	-1.3
Hand grip strength (left)	0.5	1.4	2.4	-1.5	0.9	1.0
Number of treatments/medications taken	3.0	5.3	12.8	-0.2	1.8	-3.6
Average weekly spirits intake	1.6	1.9	3.9	-1.3	0.4	-2.0
Sensitivity / hurt feelings	0.3	0.5	1.6	-0.1	-0.1	-1.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	-0.5	0.6	-1.1
Hearing difficulty/problems: Yes	0.8	1.2	2.1	1.5	0.3	-1.2
Relative age of first facial hair	0.5	0.9	1.7	-1.3	0.7	-0.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.8	0.1	-0.5	-1.9
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.5	0.7	-0.1	-0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.0	-0.6	0.0
Systolic blood pressure, automated reading	0.8	2.4	6.4	-0.2	-0.9	-2.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.0	-1.4	-0.0	0.1
Angina	0.0	0.0	0.1	0.1	0.2	-0.2
Medication for hormone replacement therapy	0.4	0.4	1.0	0.1	-1.0	-0.5
Vitamin and mineral supplements	0.2	0.3	0.6	-0.7	-0.4	-0.5
Supplements: Zinc	0.4	0.5	0.7	-0.7	0.8	0.6
Medication: Co-codamol	0.2	0.2	0.4	-0.3	-0.6	-0.5
Medication: Metformin	0.2	0.2	0.6	0.3	0.3	0.8
Diabetes (father)	0.7	0.8	1.2	-0.4	-1.1	-1.0
Diabetes (mother)	0.4	0.4	1.2	-0.3	1.1	-0.2
Severe depression (siblings)	1.3	1.4	2.7	-1.6	0.7	-1.0
Pack years adult smoking proportion	0.6	0.9	1.8	-1.4	0.2	-0.9
Impedance of leg (right)	0.4	2.0	5.7	0.3	-0.4	2.4
Leg fat-free mass (left)	0.5	2.7	4.2	-2.0	-0.1	-2.0
Trunk fat percentage	0.6	2.6	4.9	-1.6	0.6	-2.2
Hand grip strength (right)	0.4	1.0	2.5	-0.5	0.6	1.6
Townsend deprivation index at recruitment	0.5	0.7	1.3	-0.1	0.8	1.1
Current tobacco smoking	0.5	0.7	1.0	-0.8	0.8	-1.0
Average weekly fortified wine intake	0.2	0.3	0.6	-0.4	0.8	-0.1
Maternal smoking around birth	0.5	0.7	1.5	-0.6	-1.2	-0.5
Fed-up feelings	0.1	0.2	0.4	-0.1	-0.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	0.4	0.0	0.1
Relative age voice broke	0.3	0.5	1.0	-0.4	0.5	-1.0
Taking other prescription medications	1.5	2.3	5.6	0.5	1.1	-2.4
Age when periods started (menarche)	0.1	0.1	0.2	-0.5	0.1	-0.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.5	0.7	-1.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.8	9.4	2.2	0.3	3.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.4	-0.0	-1.8	0.5
Qualifications: CSEs or equivalent	0.5	0.6	0.9	0.9	0.5	-0.9
Serious illness, injury or assault to yourself	0.5	0.6	1.6	0.4	-0.1	-1.3
High blood pressure	1.3	3.6	9.4	-1.2	0.0	-3.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	0.1	0.7	-1.3
Multivitamins +/- minerals	0.0	0.0	0.1	0.3	-0.1	0.2
Stomach or abdominal pain in last month	0.8	0.9	2.1	-0.8	0.2	-1.4
Supplements: Glucosamine	0.4	0.5	1.0	1.0	-0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	0.6	0.4	-1.0
Medication: Atenolol	0.3	0.4	1.0	0.5	0.3	-1.0
Medication: Levothyroxine sodium	0.4	0.7	1.4	-0.6	0.6	-1.2
Sitting height	1.3	9.0	22.3	1.7	-4.7	1.4
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	-0.7	0.6	-0.8
High blood pressure (mother)	0.2	0.3	0.6	0.8	0.4	0.0
Body mass index (BMI)	1.2	5.2	8.6	-1.8	2.0	-2.9
Impedance of leg (left)	0.3	1.6	4.2	0.3	-0.7	2.0
Leg predicted mass (left)	0.5	2.8	4.2	-2.0	-0.2	-2.0
Trunk fat mass	0.8	3.4	6.4	-1.9	0.2	-2.5
Waist circumference	1.5	5.5	11.5	-2.0	1.0	-3.4
Number of incorrect matches in round	3.3	5.4	9.6	-3.1	1.6	-2.0
Past tobacco smoking	1.1	2.0	2.2	1.3	-1.4	1.5
Alcohol usually taken with meals	0.8	1.2	3.2	-0.4	-0.6	-1.8
Nervous feelings	0.1	0.3	0.6	-0.1	-0.8	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.4	1.2	-0.8	0.1
Hearing difficulty/problems with background noise	1.9	3.1	8.3	2.9	0.8	-0.5
Hair/balding pattern: Pattern 2	3.2	4.1	9.9	-3.1	1.1	1.0
Had menopause	0.4	0.5	1.0	-1.0	-0.5	-0.6
Had other major operations	0.3	0.3	0.8	0.9	0.4	0.3
Forced vital capacity (FVC)	0.2	0.7	1.3	-0.7	-0.5	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	6.0	1.9	-0.5	2.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.1	-0.6	0.1
Qualifications: None of the above	1.9	4.0	10.6	-1.0	0.6	-3.2
Financial difficulties in last 2 years	0.8	1.1	2.8	-0.5	-1.7	0.4
Mouth/teeth dental problems	0.4	0.7	1.2	-0.8	-1.1	0.5
Heart attack	3.1	4.0	11.1	0.2	-0.9	-3.3
Allergy	0.6	1.5	3.9	-0.6	-0.4	2.0
Pain all over the body in last month	0.5	0.6	1.1	0.8	-1.0	0.2
Diabetes (self-reported)	0.1	0.1	0.2	0.2	0.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.5	0.6	1.2	0.0
Medication: Ramipril	2.8	3.5	6.7	0.1	2.0	-2.6
Medication: Simvastatin	0.5	0.8	2.3	-0.1	0.1	-1.5
Fluid intelligence score	0.7	1.4	3.5	1.9	-0.9	0.1
Illnesses of siblings	1.3	1.8	4.9	0.1	0.7	2.2
Neuroticism score	0.5	1.1	1.9	0.6	-1.4	-1.0
Weight	0.7	3.3	5.0	-2.2	0.1	-2.2
Impedance of arm (right)	0.4	1.8	3.1	1.2	-0.8	1.8
Arm fat percentage (right)	0.8	3.3	4.4	-1.5	1.7	-2.1
Trunk fat-free mass	0.5	2.8	3.7	-1.9	-1.7	-1.4
Hip circumference	0.6	2.4	5.2	-1.2	0.7	-2.3
Time employed in main current job	0.7	0.8	1.4	-1.2	-0.5	0.8
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.3	0.1	0.6
Father’s age at death	0.4	0.5	1.1	-1.1	0.7	0.0
Worrier / anxious feelings	0.5	0.9	1.6	1.1	-1.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.4	-0.5	0.2	-1.2
Falls in the last year	0.2	0.2	0.4	0.6	-0.5	-0.2
Hair/balding pattern: Pattern 3	0.6	1.0	1.8	1.3	-0.2	-1.0
Number of live births	0.7	1.0	2.2	1.5	-0.8	0.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	2.7	0.3	-0.9	1.6
Pulse rate	1.5	2.5	4.0	-0.2	-1.9	-2.0
Happiness	0.9	1.1	2.0	1.1	-1.4	-0.3
Noisy workplace	0.2	0.2	0.4	0.6	-0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.9	1.9	2.6	1.4	1.2	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.0	0.5	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	1.2	0.5	-0.0	-1.1
Asthma	0.5	0.9	2.3	-0.1	0.7	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	0.4	0.6	0.0
Medication: Cholesterol lowering	0.6	0.9	2.4	-0.4	-0.0	-1.6
Depression (self-reported)	1.4	1.7	3.5	1.1	0.5	-1.9
Medication: Lansoprazole	0.6	0.7	2.1	-0.3	0.2	-1.4
Prospective memory result	1.9	2.4	5.9	1.1	-0.4	2.4
Lung cancer (father)	1.2	1.4	3.8	-0.3	1.9	0.6
Illnesses of mother	1.4	1.7	2.5	1.1	-1.6	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.4	0.1	-0.9	1.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.2	0.4	-0.9	1.1
Impedance of arm (left)	0.5	2.4	4.7	1.4	-0.8	2.2
Arm fat mass (right)	1.1	4.4	7.6	-2.0	1.2	-2.8
Trunk predicted mass	0.5	2.9	3.8	-1.9	-1.7	-1.4
Standing height	0.7	6.9	17.2	-1.4	-4.2	1.2
Length of working week for main job	0.2	0.2	0.4	-0.0	0.6	-0.4
Exposure to tobacco smoke at home	0.2	0.3	0.5	-0.4	0.7	-0.5
Breastfed as a baby	1.0	1.2	2.6	-0.5	-0.9	-1.6
Tense / ‘highly strung’	0.5	0.8	1.1	0.7	-0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	5.2	0.6	-1.2	-2.3
Hair/balding pattern: Pattern 4	1.0	2.4	4.0	2.0	-1.0	1.4
Birth weight of first child	2.5	4.5	12.7	0.3	-3.6	0.9
Peak expiratory flow (PEF)	1.0	2.3	5.0	2.2	0.5	1.3
Pulse wave reflection index	1.3	1.7	2.9	1.7	-0.4	1.4
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.5	-0.6	-0.5	-1.2
Loud music exposure frequency	0.2	0.2	0.5	0.7	0.3	0.2
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	3.6	1.9	0.1	1.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.0	-1.0	0.7	-0.7
Blood clot in the leg (DVT)	0.8	1.0	2.7	0.5	-1.6	-0.2
Medication: Paracetamol	1.0	1.7	2.6	-0.2	1.6	-1.5
Headache pain in last month	0.4	0.7	1.5	0.7	0.2	-1.2
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	7.3	0.9	-0.3	2.7
Glaucoma (self-reported)	0.2	0.2	0.4	0.4	0.6	-0.2
Gout (self-reported)	1.1	1.4	1.8	-1.1	1.3	-1.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.3	0.9	-0.5
Medication: Amlodipine	0.8	1.1	2.9	-0.6	-0.5	-1.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	-0.6	0.6	-1.4
Birth weight	2.6	5.7	9.9	0.9	-2.5	3.1
Chronic bronchitis/emphysema (mother)	1.5	1.8	2.6	-1.6	1.5	-0.6
High blood pressure (siblings)	0.7	1.0	2.9	0.4	-0.0	-1.7
Forced vital capacity (FVC), Best measure	0.4	1.4	2.8	-0.2	-1.2	1.7
Body fat percentage	0.9	3.5	5.6	-1.8	1.3	-2.4
Leg fat percentage (right)	1.2	4.3	5.4	-1.8	2.3	-2.0
Arm fat-free mass (right)	0.6	2.9	4.4	-2.1	-1.2	-1.7
Exposure to tobacco smoke outside home	0.7	0.9	2.3	0.5	-0.5	1.5
Comparative body size at age 10	0.2	0.4	0.8	0.4	0.9	0.6
Number of full brothers	0.0	0.0	0.0	0.0	0.1	-0.2
Worry too long after embarrassment	0.1	0.2	0.7	0.1	0.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.2	-0.6	-0.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	-0.2	0.6	-0.9
Number of children fathered	0.4	0.5	0.9	0.1	0.8	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	-0.2	-1.2	-0.1
Age at first live birth	0.7	1.3	2.3	-0.5	1.2	1.5
Pulse wave peak to peak time	0.5	0.6	1.1	-0.5	0.6	-1.1
Health satisfaction	0.1	0.2	0.5	0.1	-0.1	-0.7
Shortness of breath walking on level ground	0.6	0.7	1.1	-0.9	-0.5	-1.0
Qualifications: College or University degree	0.0	0.2	0.4	-0.3	0.0	0.6
Eye problems/disorders: None of the above	0.7	0.8	1.9	-0.5	0.5	1.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	0.9	-0.9	0.4
Emphysema/chronic bronchitis	1.1	1.2	3.4	0.4	0.2	-1.8
Medication for pain relief, constipation, heartburn	1.4	2.4	3.9	-0.5	-1.7	2.0
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.2	-0.1	-0.9
Medication: Blood pressure	2.3	4.0	9.3	-1.2	1.1	-3.0
Angina (self-reported)	0.2	0.2	0.6	0.1	0.4	-0.8
Migraine (self-reported)	0.2	0.3	0.5	0.7	0.5	-0.4
Medication: Ibuprofen	0.3	0.3	0.7	0.5	0.9	0.3
Medication: Allopurinol	1.1	1.4	2.3	-0.9	1.5	-1.1
Medication: Omeprazole	1.1	1.3	2.9	-1.0	0.1	-1.7
Medication: Seretide 50 evohaler	2.4	2.8	5.3	-1.1	1.4	-2.3
Mean time to correctly identify matches	2.6	4.9	12.1	-1.4	0.7	-3.5
Heart disease (mother)	0.6	0.8	1.1	-1.1	1.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-0.4	0.5	-1.2
Whole body fat mass	1.1	4.5	7.7	-2.2	1.0	-2.8
Leg fat mass (right)	1.3	4.9	6.6	-2.2	1.8	-2.6
Arm predicted mass (right)	0.6	2.9	4.0	-2.0	-1.2	-1.8
Pulse rate, automated reading	2.4	7.7	16.5	-1.8	-1.8	-4.1
Alcohol intake frequency.	0.2	0.4	1.0	-1.0	-0.0	-0.4
Comparative height size at age 10	0.3	1.7	4.6	-0.1	-2.1	0.6
Number of full sisters	0.4	0.5	0.7	-0.8	-0.9	-0.1
Suffer from ‘nerves’	0.2	0.4	0.7	0.8	-0.6	-0.4
Overall health rating	0.6	1.4	3.0	-1.0	-0.4	-1.7
Chest pain or discomfort	1.2	1.8	3.1	-1.4	0.5	-1.8
Had major operations	1.4	1.6	2.5	1.6	-1.5	-0.2
Age at last live birth	0.9	1.3	2.6	0.2	1.1	1.6
Family relationship satisfaction	0.5	0.6	1.3	0.4	-0.5	-1.2
Leg pain on walking	0.4	0.5	1.0	-1.0	0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.8	0.2	0.9	0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.3	1.8	-1.4	0.6	-1.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.5	0.7	1.9	0.9
Medication: Aspirin	1.3	1.8	3.2	-0.6	1.3	-1.8
Supplements: Vitamin C	0.2	0.2	0.5	0.7	-0.0	0.5
Knee pain experienced in last month	1.4	2.1	5.6	0.8	0.4	-2.4
Hypertension (Self-reported)	1.4	3.8	9.8	-1.2	0.2	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.1	0.8	-1.2	-1.5
Illnesses of father: Heart disease	0.8	1.2	1.8	-0.8	-1.4	-1.1
Illnesses of siblings: Diabetes	0.3	0.3	0.5	0.6	-0.7	0.2
Smoking status: Previous	1.1	1.7	2.5	-1.3	1.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.4	-0.3	0.0	0.6
Whole body fat-free mass	0.5	2.9	4.4	-2.1	-1.2	-1.7
Leg fat-free mass (right)	0.5	2.7	4.1	-1.9	-0.5	-2.0
Arm fat percentage (left)	0.8	3.0	4.1	-1.3	1.8	-2.0
Average weekly red wine intake	0.7	1.1	1.3	-1.1	-1.1	-0.8
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.1	-1.8	-0.8	-1.1
Mood swings	0.1	0.2	0.5	0.7	0.3	0.1
Loneliness, isolation	0.9	1.2	3.0	0.8	0.1	-1.7
Long-standing illness, disability or infirmity	3.8	5.7	7.4	-2.3	2.1	-2.7
Ever had bowel cancer screening	0.2	0.2	0.5	0.3	-0.3	-0.7
Diabetes diagnosed by doctor	0.3	0.4	1.1	0.4	1.1	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.0	0.8	0.9	1.0
Friendships satisfaction	2.4	2.9	4.7	2.0	-2.2	-0.4
Qualifications: nursing, teaching	2.0	3.1	5.6	1.8	0.7	2.4
Commuting to job workplace: Walk	0.8	0.9	2.3	0.2	-0.5	1.5
Eye problems/disorders: Cataract	0.3	0.4	0.8	0.2	0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.3	0.4	0.8
Medication for cholesterol	1.2	1.8	5.2	0.3	-0.4	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.3	-0.4	1.8	-0.1
Back pain experienced in last month	0.2	0.2	0.4	-0.6	-0.1	-0.6
Mineral and other dietary supplements	0.6	0.9	2.0	0.7	-0.1	1.4
Breast cancer (self-reported)	0.8	1.0	2.9	1.7	-0.1	0.3
Asthma (self-reported)	0.6	1.2	2.9	-0.0	0.8	-1.7
Osteoporosis (self-reported)	1.7	2.2	3.0	1.7	-1.7	-0.8
Osteoarthritis (self-reported)	0.9	1.1	2.8	-0.6	0.4	-1.7
Medication: Aspirin	1.8	2.3	4.5	-1.1	1.2	-2.1
Medication: Gliclazide	0.1	0.1	0.1	0.3	-0.4	-0.1
Illnesses of father: None of the above (group 1)	1.5	1.9	3.1	1.0	1.8	1.2
Smoking status: Current	0.1	0.1	0.2	-0.3	0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	8.9	1.1	0.0	3.0
Whole body water mass	0.5	3.0	4.4	-2.1	-1.2	-1.8
Leg predicted mass (right)	0.5	2.7	3.9	-2.0	-0.5	-2.0
Arm fat mass (left)	0.8	3.5	5.8	-1.8	1.2	-2.4
Number of self-reported non-cancer illnesses	2.5	4.3	10.4	1.5	-0.4	-3.2
Average weekly champagne plus white wine intake	0.7	1.0	3.0	-1.7	0.1	0.3
Miserableness	2.3	4.0	5.3	2.2	-2.3	-1.3
Guilty feelings	0.2	0.3	0.8	-0.3	-0.1	-0.9
Wears glasses or contact lenses	0.0	0.0	0.0	0.1	0.0	0.1
Ever taken oral contraceptive pill	0.4	0.5	0.8	0.9	0.7	0.3
Hearing aid user	0.3	0.3	0.5	-0.2	-0.7	-0.6
Mother’s age at death	0.9	1.1	2.4	0.6	-0.7	-1.5
Financial situation satisfaction	0.9	1.1	2.3	-0.3	-0.9	-1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.1	0.5	0.1	-1.5
Commuting to job workplace: Public transport	1.5	1.8	5.2	-0.0	-2.3	0.6
Eye problems/disorders: Glaucoma	0.0	0.1	0.1	0.1	0.3	-0.3
Medication: Blood pressure	1.4	2.7	7.0	-0.5	0.9	-2.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	-0.0	-1.2	-0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.4	2.7	-1.6	0.5	-1.1
High cholesterol (Self-reported)	1.2	2.1	5.5	0.9	-0.3	-2.3
Medication: Bendroflumethiazide	2.5	3.8	6.8	-2.0	-0.7	-2.6
Medication: Paracetamol	1.5	2.3	4.2	-0.3	2.0	-1.6
Medication: Lisinopril	0.8	1.1	1.8	0.6	1.0	-1.3
Medication: Atorvastatin	1.0	1.3	1.9	-1.4	-0.3	-1.3
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.5	-0.9	0.2
Alcohol drinker status: Never	1.8	2.2	4.0	-0.3	-2.0	1.6
Ever smoked	1.8	3.2	4.7	-1.8	2.2	-1.3
Basal metabolic rate	0.6	3.1	5.1	-2.3	-0.8	-1.9
Leg fat percentage (left)	1.2	4.2	5.0	-1.7	2.2	-2.2
Arm fat-free mass (left)	0.7	3.3	5.7	-2.4	-0.9	-1.9
Number of operations (self-reported)	2.1	3.1	6.8	2.6	-1.4	-0.9
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.4	0.1	0.8
Irritability	1.2	2.1	3.6	1.5	-1.9	-0.7
Risk taking	1.1	1.6	3.0	1.3	0.0	1.7
Ever had prostate specific antigen (PSA) test	2.1	2.4	4.0	1.3	-1.2	2.0
Fractured/broken bones in last 5 years	0.5	0.6	1.0	-0.5	1.0	-0.8
Age started oral contraceptive pill	1.5	1.8	4.9	0.7	-2.2	-0.4
Diastolic blood pressure, automated reading	1.1	3.5	8.7	0.1	-2.9	-1.3
Ever depressed for a whole week	1.3	1.6	4.6	0.0	-2.2	-0.5
Unable to work because of sickness or disability	0.0	0.0	0.0	-0.1	0.1	-0.2
Commuting to job workplace: Cycle	2.5	3.1	6.8	2.6	0.0	1.6
Myopia	0.9	1.2	2.5	1.0	1.6	-0.5
Vascular/heart problems diagnosed by doctor	1.9	5.2	12.7	1.7	-0.1	3.6
Cholesterol lowering medication	0.3	0.4	0.9	-0.5	0.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	3.2	-1.0	-0.7	-1.8
Pain experienced in last month	0.6	1.0	1.2	-0.8	1.0	1.1
Supplements: Calcium	1.1	1.2	1.8	1.2	-1.3	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.6	0.1	0.4
Heart attack/myocardial infarction (self-reported)	2.7	3.5	10.3	0.1	-0.5	-3.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	0.3	-1.6	-0.4
Heart disease (siblings)	1.7	2.1	3.2	-0.1	-1.7	-1.8
Alcohol drinker status: Previous	0.6	0.7	2.1	-0.0	-0.3	-1.4
Pack years of smoking	0.4	0.6	0.9	-1.0	-0.1	-0.9
Impedance of whole body	0.4	2.3	4.9	0.9	-1.1	2.2
Leg fat mass (left)	1.2	4.9	7.3	-2.1	1.6	-2.7
Arm predicted mass (left)	0.7	3.5	4.7	-2.2	-1.4	-1.9