Hub : Genes

UBR7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1143	0.0481	0.00540	0.129	NA	0.090	NA	0.119	2.0e-09	NA	6.4e-07	NA	9.1e-09
2	GTEx	Skin Sun Exposed Lower leg	0.1110	0.0430	0.00190	0.081	NA	0.048	NA	0.057	3.1e-07	NA	7.3e-05	NA	1.6e-05
3	YFS	Blood	0.1299	0.0247	0.00000	0.105	0.078	0.101	0.101	0.107	2.0e-32	2.1e-24	2.1e-31	2.7e-31	4.8e-33
4	TCGA	Brain Lower Grade Glioma	0.0671	0.0315	0.00140	0.040	0.027	0.042	NA	0.054	2.0e-05	4.6e-04	1.4e-05	NA	9.1e-07
5	TCGA	Lung Adenocarcinoma	0.0364	0.0159	0.00028	0.031	0.026	0.023	NA	0.025	1.2e-04	4.8e-04	9.1e-04	NA	5.5e-04
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.0660	0.0370	0.00550	0.000	0.022	0.006	NA	0.000	3.3e-01	1.1e-02	1.3e-01	NA	3.3e-01
7	TCGA	Thyroid Carcinoma	0.0610	0.0300	0.00190	0.042	0.026	0.028	NA	0.039	5.2e-05	1.2e-03	9.4e-04	NA	1.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	1.0	1.8	-0.8	-0.7	0.8	-1.0	-1.4	-1.3	-0.5
Bipolar Disorder or Schizophrenia	0.6	1.3	5.1	-0.9	-0.8	0.9	-1.0	-0.9	-2.3	-0.4
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	0.1	0.4	-0.3	-0.5	-0.2	0.5	0.1
Depression (Nagel 2018)	1.3	2.0	3.7	-1.5	-1.5	1.4	-1.9	-0.4	-1.2	-1.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	7.4	-0.1	-0.1	0.1	0.7	-0.5	-2.7	-0.4
Neuroticism (Nagel 2018)	0.1	0.2	1.0	-0.3	0.0	0.1	-1.0	0.4	0.2	0.0
Schizophrenia (2018)	0.3	0.6	3.3	-0.5	-0.5	0.5	-0.5	-0.1	-1.8	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	1.7	0.9	0.8	-0.9	1.3	0.6	-0.9	0.8
Worry (Nagel 2018)	0.1	0.1	0.4	0.0	0.2	-0.1	-0.1	0.4	-0.3	0.6
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.3	-0.2	0.1	-0.0	0.2	-0.1	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.1	-0.1	0.1	-0.5	-0.4	0.0	0.1
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.0	0.1	-0.1	0.3	-0.1	0.0	0.1
Crohns Disease (2017)	2.8	6.2	7.0	2.5	2.6	-2.6	2.0	2.6	2.6	2.5
Irritable Bowel Disease (IBD)	2.6	6.3	9.4	2.4	2.6	-2.5	1.5	3.1	2.8	2.4
Ulcerative Colitis (UC)	0.7	1.4	2.5	1.1	1.2	-1.1	0.4	1.6	1.5	1.1
Major Depression (MDD)	3.6	4.4	11.5	-2.1	-1.9	1.9	-3.4	-1.3	-0.8	-2.3
Reaction Time	0.5	1.0	2.4	0.8	0.8	-0.8	1.2	0.6	1.6	0.8
Verbal and Numeric Reasoning (VNR)	0.4	1.0	5.7	-0.4	-0.3	0.3	-0.3	-0.7	-2.4	-0.5
Breast Cancer	0.5	1.3	1.5	-1.2	-1.2	1.2	-1.2	-0.8	-1.1	-1.2
Ovarian Cancer	0.2	0.3	0.6	0.7	0.4	-0.7	0.8	-0.1	0.1	0.5
Prostate Cancer	0.1	0.1	0.4	-0.0	0.4	-0.0	-0.2	-0.1	-0.7	0.1
Age at First Birth	0.4	0.5	2.7	-0.3	-0.3	0.3	-0.5	-0.5	-1.7	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.0	2.7	0.8	0.9	-0.8	0.5	1.6	1.5	0.4
Coronary Artery Disease (CAD)	0.8	1.0	1.5	1.1	1.2	-1.1	0.0	0.6	1.2	1.0
Crohns Disease (2012)	1.5	2.4	5.2	1.5	1.6	-1.5	2.3	1.1	1.4	1.2
Mean Putamen Volume	1.8	2.0	4.8	-1.4	-1.4	1.5	-0.6	-0.4	-2.2	-1.5
Fasting Glucose	0.5	0.6	1.2	0.8	0.8	-0.7	1.1	0.4	0.4	0.9
HbA1C	0.2	0.2	0.6	-0.4	-0.4	0.4	-0.7	-0.8	-0.1	-0.3
HDL Cholesterol	0.2	0.4	1.3	0.5	0.7	-0.5	1.1	-0.3	-0.4	0.5
LDL Cholesterol	0.3	0.4	0.9	0.7	0.8	-0.8	0.5	1.0	0.1	0.5
Lupus	1.5	2.2	3.1	1.6	1.8	-1.6	1.7	-0.1	1.4	1.5
Neuroticism (2016)	0.8	1.1	4.5	1.0	0.9	-1.0	0.2	2.1	0.4	0.7
Primary Biliary Cirrhosis	0.5	0.7	1.2	-1.0	-0.9	1.0	-0.2	-1.1	-0.4	-0.9
Rheumatoid Arthritis	0.4	0.5	1.7	-0.2	-0.1	0.2	-1.3	-1.3	-0.6	-0.0
Schizophrenia (2014)	0.4	0.9	5.6	-0.5	-0.4	0.5	-0.0	-0.2	-2.4	-0.2
Triglycerides	0.7	1.1	2.9	1.0	0.8	-1.0	1.7	1.2	0.5	0.9
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.1	-0.0	0.1	0.3	-0.5	-0.1	-0.1
Ulcerative Colitis	0.0	0.1	0.2	0.2	0.4	-0.2	0.1	0.5	0.1	0.1
Blood Eosinophil Count	0.3	2.5	8.5	1.5	1.5	-1.6	0.6	0.5	2.9	1.4
Blood Platelet Count	0.1	1.6	8.2	0.3	0.1	-0.3	-1.1	1.1	2.9	-0.3
Blood Red Count	0.0	0.1	0.2	0.4	0.4	-0.4	-0.0	-0.4	0.4	0.4
Blood White Count	1.2	9.1	14.1	3.0	3.1	-3.3	1.3	3.7	3.4	2.6
Heel T-Score	0.2	1.5	7.6	0.8	0.7	-0.8	0.8	2.8	-0.1	1.0
BMI	0.7	4.2	22.5	0.4	0.5	-0.8	-1.6	1.8	4.7	-0.8
Height	0.8	14.6	18.8	4.0	4.3	-4.0	3.1	3.6	3.5	3.9
Waist Hip Ratio (WHR)	0.3	1.2	1.9	-1.1	-1.3	1.0	-1.4	-0.0	-1.3	-1.1
Systolic Blood Pressure	0.2	1.2	2.5	1.1	1.2	-1.0	1.6	-0.4	0.0	1.4
Smoking Status	0.3	0.6	1.3	0.7	0.7	-0.9	1.0	0.3	1.2	0.6
Allergy or Eczema	0.4	1.1	3.9	-0.7	-0.6	0.7	0.0	-2.0	-1.5	-0.6
Cardiovascular Disease	0.7	2.3	4.5	-1.5	-1.5	1.4	-2.1	-1.2	-0.8	-1.8
Hypothyroidism (self reported)	1.0	2.4	4.5	-1.6	-1.9	1.5	-1.0	-2.1	-0.1	-1.6
Respiratory disease	1.3	2.8	4.8	1.9	1.8	-2.1	2.2	0.2	1.0	1.6
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.8	0.8	0.8	-0.9	0.1	1.7	1.0	0.6
Lung FEV1/FVC ratio	1.8	9.0	17.3	-3.2	-3.1	3.1	-4.2	-1.4	-2.4	-2.9
Lung FVC	0.3	1.3	4.4	-1.0	-0.9	1.3	-0.7	-0.7	-2.1	-0.4
Neuroticism	0.2	0.4	1.3	0.2	0.5	-0.4	-0.6	1.1	0.6	0.5
Chronotype (morning person)	0.7	1.7	3.5	1.0	1.0	-1.0	0.7	1.9	1.7	1.3
Hair Pigment	0.1	2.0	4.3	-1.0	-0.7	1.0	-1.6	-1.7	-1.2	-2.1
Tanning	0.2	2.3	3.5	-1.7	-1.9	1.6	-1.0	-1.5	0.9	-1.7
Hand grip strength (left)	0.1	0.2	0.3	0.5	0.4	-0.4	0.2	0.4	-0.4	0.4
Number of treatments/medications taken	0.2	0.4	1.8	-0.5	-0.5	0.3	-0.5	0.2	0.2	-1.3
Average weekly spirits intake	0.2	0.3	0.5	0.5	0.5	-0.5	0.7	0.5	0.5	0.3
Sensitivity / hurt feelings	0.5	0.9	2.0	0.9	1.1	-1.0	0.4	0.8	0.5	1.4
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.3	-1.1	-1.0	1.0	-1.8	0.1	-0.9	-1.6
Hearing difficulty/problems: Yes	0.2	0.3	1.6	0.4	0.3	-0.5	0.4	0.3	-1.2	-0.1
Relative age of first facial hair	1.6	3.3	5.8	-1.9	-1.8	1.9	-0.5	-0.9	-2.4	-2.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.0	0.2	-0.1	0.5	-0.4	0.4	-0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.8	0.8	0.7	-0.9	-0.1	1.7	0.9	0.2
Ever had hysterectomy (womb removed)	0.7	0.8	3.1	-0.8	-0.7	0.7	-1.8	-0.3	0.7	-0.6
Systolic blood pressure, automated reading	0.6	1.8	2.4	1.5	1.5	-1.5	1.4	0.5	1.2	1.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.2	0.0	-0.2	-0.2	0.6	0.4	0.2
Angina	0.7	0.9	3.2	0.7	0.9	-0.7	0.1	1.1	1.8	0.6
Medication for hormone replacement therapy	0.0	0.0	0.1	0.1	0.0	-0.2	-0.0	0.0	-0.2	0.4
Vitamin and mineral supplements	1.0	1.4	2.5	1.2	1.1	-1.3	0.2	1.6	1.3	1.0
Supplements: Zinc	1.8	2.0	2.5	-1.6	-1.4	1.6	-1.3	-1.5	-1.1	-1.4
Medication: Co-codamol	0.4	0.4	1.0	0.5	0.5	-0.5	0.5	1.0	1.0	0.2
Medication: Metformin	0.7	1.0	2.5	-0.9	-1.0	0.8	-1.6	0.5	-0.9	-1.0
Diabetes (father)	2.4	3.0	5.0	-1.8	-1.7	1.8	-1.8	-1.0	-2.2	-1.6
Diabetes (mother)	0.7	0.8	1.8	-0.9	-0.9	0.8	-1.1	-0.6	0.2	-1.3
Severe depression (siblings)	1.1	1.2	1.8	1.1	1.3	-1.2	1.1	0.0	1.1	1.2
Pack years adult smoking proportion	1.2	1.9	5.7	-1.1	-1.0	1.1	-2.4	-0.4	1.6	-1.2
Impedance of leg (right)	0.4	2.0	12.3	-0.6	-0.7	0.8	0.2	-0.1	-3.5	0.0
Leg fat-free mass (left)	1.1	5.9	22.5	1.9	2.0	-2.1	0.5	2.4	4.7	1.0
Trunk fat percentage	1.2	4.6	16.2	1.6	1.5	-1.8	-0.2	2.9	4.0	0.4
Hand grip strength (right)	0.1	0.1	0.3	0.4	0.3	-0.4	0.6	0.1	0.0	0.4
Townsend deprivation index at recruitment	0.7	1.0	5.5	0.5	0.7	-0.5	-0.2	0.4	2.3	0.3
Current tobacco smoking	0.1	0.2	1.0	-0.0	0.2	0.0	-0.4	-1.0	0.2	0.4
Average weekly fortified wine intake	1.1	1.3	2.5	-1.3	-1.3	1.2	-1.0	-0.5	-0.4	-1.6
Maternal smoking around birth	1.6	2.4	3.1	-1.7	-1.8	1.7	-1.6	-1.6	-0.2	-1.6
Fed-up feelings	0.5	0.9	4.2	0.6	0.8	-0.7	-0.4	0.5	2.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.8	-1.0	-1.0	0.8	-2.0	-0.4	-1.0	-1.2
Relative age voice broke	2.3	3.6	4.4	-2.0	-2.1	2.0	-1.5	-1.8	-1.7	-2.1
Taking other prescription medications	0.1	0.2	0.8	-0.3	-0.2	0.2	-0.3	-0.3	-0.5	-0.9
Age when periods started (menarche)	0.3	0.6	1.7	-0.6	-0.9	0.5	-0.5	-0.3	-1.3	-0.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.0	-0.0	-0.0	-0.5	-0.4	0.7	0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	5.8	2.1	2.2	-2.2	1.3	2.2	1.9	2.4
Tinnitus: Yes, but not now, but have in the past	3.3	3.5	4.6	2.0	2.1	-2.1	2.0	1.6	1.4	1.7
Qualifications: CSEs or equivalent	0.6	0.8	2.0	0.7	0.7	-0.8	0.9	0.4	-0.9	1.4
Serious illness, injury or assault to yourself	1.2	1.5	2.4	1.3	1.2	-1.3	1.2	1.6	1.1	0.8
High blood pressure	0.2	0.4	1.6	-0.0	-0.2	0.0	-1.3	0.5	1.0	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.9	-0.7	-0.5	0.7	-0.3	-1.4	-1.7	-0.5
Multivitamins +/- minerals	1.6	2.1	3.6	-1.5	-1.4	1.5	-0.3	-1.9	-1.7	-1.3
Stomach or abdominal pain in last month	0.7	0.9	2.2	1.1	1.1	-1.1	1.5	0.3	0.2	0.6
Supplements: Glucosamine	0.4	0.5	1.1	-0.8	-0.9	0.7	-0.6	-0.0	-0.2	-1.0
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.8	-1.3	-1.2	1.4	-1.4	-1.1	-2.2	-1.0
Medication: Atenolol	0.6	0.8	2.2	0.2	0.4	-0.2	-1.1	1.5	1.4	0.3
Medication: Levothyroxine sodium	0.4	0.6	2.1	-0.7	-1.0	0.6	-0.1	-1.4	-0.0	-0.7
Sitting height	0.6	4.0	12.3	1.6	1.7	-1.6	1.6	1.4	3.5	1.6
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	0.4	0.5	-0.4	-0.7	-0.0	1.1	0.3
High blood pressure (mother)	0.5	0.7	1.6	-0.9	-0.9	0.8	-0.8	0.4	-0.5	-1.3
Body mass index (BMI)	0.9	3.8	18.7	0.7	0.7	-1.0	-1.3	2.0	4.3	-0.6
Impedance of leg (left)	0.4	2.1	11.6	-1.0	-1.0	1.1	-0.1	-0.6	-3.4	-0.3
Leg predicted mass (left)	1.1	5.7	22.0	1.8	1.9	-2.0	0.4	2.4	4.7	1.0
Trunk fat mass	1.3	5.6	21.5	1.6	1.6	-1.8	-0.4	3.0	4.6	0.4
Waist circumference	1.4	5.1	20.2	1.2	1.1	-1.5	-0.9	3.2	4.5	-0.1
Number of incorrect matches in round	4.2	7.1	10.2	2.9	2.8	-2.7	2.0	2.1	2.6	3.2
Past tobacco smoking	0.1	0.2	0.5	-0.2	-0.2	0.5	-0.5	-0.7	-0.2	0.5
Alcohol usually taken with meals	0.1	0.2	0.4	0.3	-0.0	-0.1	0.6	0.6	-0.5	-0.3
Nervous feelings	0.1	0.3	1.5	-0.5	-0.3	0.3	-1.2	-0.0	-0.2	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.7	-0.7	-0.6	0.4	-1.6	-0.1	0.4	-0.9
Hearing difficulty/problems with background noise	0.6	1.0	1.9	1.2	1.2	-1.4	0.8	0.6	0.9	0.1
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	-0.9	-0.8	1.0	-1.2	-0.7	0.2	-1.1
Had menopause	0.3	0.3	0.7	-0.5	-0.4	0.5	-0.8	0.3	-0.7	-0.7
Had other major operations	0.4	0.5	2.5	-0.1	0.3	-0.0	-0.6	0.5	1.6	-0.1
Forced vital capacity (FVC)	0.3	1.1	2.4	0.9	1.0	-0.8	1.2	1.0	0.5	1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	5.9	1.7	1.7	-1.8	1.0	2.4	2.2	1.9
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	4.7	-1.6	-1.6	1.5	-2.2	-0.5	-1.2	-1.3
Qualifications: None of the above	0.9	1.9	7.1	1.3	1.3	-1.3	0.5	-0.1	2.7	1.0
Financial difficulties in last 2 years	1.1	1.5	3.5	-1.2	-1.1	1.2	-1.1	-1.9	-0.3	-1.2
Mouth/teeth dental problems	0.3	0.4	1.0	-0.6	-0.8	0.8	0.6	0.0	-1.0	-0.4
Heart attack	0.1	0.2	0.6	0.3	0.5	-0.2	0.4	0.4	0.8	0.1
Allergy	0.2	0.4	1.7	-0.4	-0.5	0.5	-0.4	1.3	0.3	-0.5
Pain all over the body in last month	0.5	0.6	3.4	-0.2	0.0	0.2	-0.5	-1.9	0.3	0.1
Diabetes (self-reported)	0.1	0.1	0.3	0.2	0.3	-0.4	-0.1	0.4	-0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.3	1.1	1.1	-1.1	0.9	-0.2	0.6	1.0
Medication: Ramipril	0.3	0.4	1.1	0.7	0.7	-0.8	0.3	0.2	1.1	0.2
Medication: Simvastatin	0.4	0.6	2.4	-0.2	-0.3	0.1	-0.7	-0.8	1.5	-0.5
Fluid intelligence score	1.1	2.3	6.0	-1.4	-1.2	1.2	-0.7	-1.8	-2.4	-1.4
Illnesses of siblings	0.2	0.3	1.1	-0.4	-0.5	0.6	0.1	-0.1	-1.0	0.4
Neuroticism score	0.4	0.8	2.2	0.7	0.9	-0.9	-0.3	1.5	0.8	0.7
Weight	1.3	6.6	27.1	1.7	1.7	-2.0	-0.4	2.9	5.2	0.5
Impedance of arm (right)	0.5	2.4	6.1	1.0	0.8	-0.8	2.3	0.3	-2.5	1.6
Arm fat percentage (right)	1.0	4.1	16.2	1.4	1.3	-1.7	-0.1	2.4	4.0	0.2
Trunk fat-free mass	0.5	2.8	11.8	1.2	1.3	-1.3	-0.1	1.6	3.4	0.7
Hip circumference	1.9	8.4	30.2	2.2	2.3	-2.5	0.7	3.3	5.5	1.0
Time employed in main current job	0.8	0.9	1.7	-1.0	-1.1	1.0	-0.9	-1.3	0.1	-0.8
Alcohol intake versus 10 years previously	0.6	0.9	1.2	-1.1	-1.1	0.9	-0.9	-0.9	0.2	-1.1
Father’s age at death	0.3	0.4	1.8	0.4	0.1	-0.4	1.3	0.7	0.2	0.1
Worrier / anxious feelings	0.3	0.5	2.0	0.6	0.6	-0.7	0.4	1.4	0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.4	-0.7	-0.5	0.7	-1.5	-0.7	1.1	-1.2
Falls in the last year	0.1	0.1	0.8	-0.1	-0.1	0.1	0.1	-0.4	-0.9	-0.3
Hair/balding pattern: Pattern 3	0.4	0.6	3.3	-0.3	-0.5	0.3	0.5	0.2	-1.8	-0.7
Number of live births	0.1	0.1	0.5	0.0	0.1	-0.1	-0.1	0.2	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.6	-0.3	-0.1	0.3	0.0	0.6	-0.8	0.6
Pulse rate	0.3	0.4	0.8	-0.6	-0.6	0.6	-0.9	0.1	-0.8	-0.7
Happiness	0.8	1.0	1.6	-1.0	-1.0	0.9	-1.3	-0.8	-1.1	-0.9
Noisy workplace	0.7	0.9	1.2	-1.0	-1.0	0.8	-0.3	-1.1	-1.1	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.9	-0.6	-0.5	0.6	-0.7	-0.2	-1.0	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.7	1.1	1.1	-1.3	0.3	0.8	1.2	0.8
Mouth/teeth dental problems: Dentures	0.5	0.9	1.9	-0.6	-0.7	0.4	-1.4	-1.2	1.0	-0.9
Asthma	1.1	2.2	3.3	1.7	1.7	-1.8	1.4	-0.0	1.5	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.0	-0.5	-0.5	0.5	0.2	0.7	0.3	-1.0
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.3	-0.3	0.1	-0.4	0.3	0.6	-0.6
Depression (self-reported)	0.2	0.2	1.5	-0.1	0.0	0.1	-1.2	0.1	0.1	0.1
Medication: Lansoprazole	2.7	3.1	5.2	-1.7	-1.9	1.6	-2.3	-1.6	-0.7	-2.1
Prospective memory result	0.9	1.1	2.5	1.2	1.1	-1.1	0.7	1.6	0.5	0.6
Lung cancer (father)	0.3	0.4	0.6	0.7	0.8	-0.8	0.0	0.6	0.6	0.7
Illnesses of mother	0.3	0.3	1.3	0.5	0.5	-0.4	0.4	-0.4	-0.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.8	0.0	0.1	0.0	0.4	0.7	-0.6	0.9
Pulse wave Arterial Stiffness index	3.1	3.7	10.3	1.7	1.6	-1.6	0.3	1.7	3.2	2.1
Impedance of arm (left)	0.6	2.6	6.3	1.2	1.1	-1.1	2.5	0.7	-2.0	1.9
Arm fat mass (right)	1.0	4.2	19.1	1.2	1.1	-1.4	-0.6	2.3	4.4	-0.1
Trunk predicted mass	0.5	2.8	11.6	1.2	1.3	-1.2	-0.2	1.7	3.4	0.6
Standing height	0.5	5.1	6.1	2.3	2.4	-2.3	2.0	2.1	2.3	2.5
Length of working week for main job	0.7	0.8	1.2	1.1	1.0	-1.0	1.1	0.3	0.5	0.7
Exposure to tobacco smoke at home	0.8	0.9	1.8	-0.8	-0.9	0.7	-0.4	-1.3	0.4	-1.4
Breastfed as a baby	0.9	1.1	5.1	0.7	0.7	-0.8	0.5	2.2	0.5	0.5
Tense / ‘highly strung’	0.6	0.9	1.7	-1.1	-0.9	0.9	-0.7	-0.7	-1.3	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	2.4	-0.9	-0.4	0.6	-1.1	-1.6	0.6	-0.8
Hair/balding pattern: Pattern 4	0.4	1.0	1.7	1.2	1.3	-1.2	0.7	0.4	0.7	1.0
Birth weight of first child	0.6	1.1	2.9	0.8	0.6	-1.0	0.1	1.7	1.6	0.6
Peak expiratory flow (PEF)	0.1	0.3	0.9	0.5	0.5	-0.5	0.8	0.2	0.1	1.0
Pulse wave reflection index	4.0	4.9	8.1	2.2	2.5	-2.2	1.2	1.7	2.8	2.5
Ever highly irritable/argumentative for 2 days	2.2	2.6	3.8	-1.6	-1.4	1.5	-1.9	-1.5	-1.2	-2.0
Loud music exposure frequency	1.8	2.0	3.5	-1.2	-1.2	1.2	-1.7	-0.7	-1.9	-1.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	-0.9	-0.7	0.8	-0.8	-0.6	-1.2	-0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.7	0.8	0.9	-0.9	0.4	0.6	0.2	0.7
Blood clot in the leg (DVT)	0.6	0.8	1.3	0.9	1.0	-0.9	0.8	0.4	1.0	1.1
Medication: Paracetamol	0.3	0.5	1.0	0.6	0.7	-0.7	1.0	1.0	0.7	0.3
Headache pain in last month	0.3	0.5	2.3	-0.1	-0.3	0.2	0.1	0.9	-1.5	-0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	0.2	0.2	-0.1	0.4	-0.5	-0.7	0.8
Glaucoma (self-reported)	0.3	0.4	1.5	0.5	0.7	-0.4	-0.3	0.1	1.2	0.4
Gout (self-reported)	0.5	0.7	1.3	1.1	0.9	-1.1	0.8	0.6	0.0	0.7
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.9	-1.5	-1.8	1.4	-0.8	-2.0	-1.2	-1.6
Medication: Amlodipine	0.2	0.3	1.5	0.3	0.2	-0.3	0.4	0.3	-1.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.0	-0.1	0.0	-0.6	-0.6	-0.2	-0.3
Birth weight	0.1	0.3	0.4	0.6	0.5	-0.7	0.6	-0.3	-0.1	0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.6	0.5	0.7	-0.6	0.9	0.3	1.3	0.5
High blood pressure (siblings)	0.7	0.9	2.2	1.1	1.1	-1.1	0.6	0.5	1.5	0.3
Forced vital capacity (FVC), Best measure	0.5	1.8	3.9	1.2	1.3	-1.1	1.5	1.2	0.6	2.0
Body fat percentage	1.0	4.1	15.4	1.2	1.2	-1.5	-0.7	2.8	3.9	0.0
Leg fat percentage (right)	0.9	3.2	12.8	0.6	0.6	-0.8	-1.5	2.4	3.6	-0.6
Arm fat-free mass (right)	0.6	3.1	15.6	0.8	0.9	-0.9	-1.0	1.8	4.0	0.0
Exposure to tobacco smoke outside home	1.8	2.4	3.8	-1.3	-1.4	1.2	-1.8	-1.9	0.9	-1.9
Comparative body size at age 10	0.4	1.1	3.3	-0.6	-0.6	0.6	-1.3	-0.6	1.8	-1.1
Number of full brothers	0.5	0.7	4.0	0.1	-0.0	-0.3	-0.6	0.2	2.0	-0.4
Worry too long after embarrassment	0.4	0.7	1.5	-0.7	-0.5	0.5	-0.9	1.2	-0.8	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.3	0.0	0.3	-0.2	0.1	-0.3	1.1	0.0
Wheeze or whistling in the chest in last year	0.5	1.0	3.6	0.8	0.9	-1.1	-0.1	-0.1	1.9	0.6
Number of children fathered	2.6	2.9	4.5	-1.8	-1.9	1.8	-1.8	-1.0	-1.3	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.9	-0.6	-0.7	0.8	-0.1	-1.7	-0.8	-0.6
Age at first live birth	0.2	0.4	2.2	0.1	0.1	0.1	0.4	-0.3	-1.5	0.8
Pulse wave peak to peak time	2.2	2.6	8.6	-1.3	-1.2	1.2	0.0	-1.4	-2.9	-1.7
Health satisfaction	0.1	0.2	0.4	0.4	0.3	-0.5	0.6	0.3	0.5	0.1
Shortness of breath walking on level ground	0.1	0.1	0.3	0.3	0.2	-0.3	-0.1	-0.1	0.6	0.0
Qualifications: College or University degree	0.3	1.0	3.7	-0.9	-0.8	0.9	0.2	-0.3	-1.9	-0.8
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.7	-0.6	0.6	-0.3	-0.2	-0.2	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.3	0.3	-0.2	0.1	-0.1	0.4	0.2
Emphysema/chronic bronchitis	0.6	0.6	1.2	-0.6	-0.5	0.5	-1.0	-1.1	0.7	-0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	2.1	1.0	0.9	-0.9	0.6	0.1	-0.2	1.4
Neck or shoulder pain in last month	0.8	1.1	2.1	1.2	1.3	-1.3	-0.0	1.5	0.5	0.6
Medication: Blood pressure	0.0	0.1	0.2	0.1	0.1	-0.0	-0.3	0.3	-0.0	-0.5
Angina (self-reported)	0.7	0.9	3.4	0.6	0.8	-0.7	-0.1	1.1	1.8	0.5
Migraine (self-reported)	1.7	2.1	2.9	1.3	1.2	-1.3	1.5	1.7	1.7	1.3
Medication: Ibuprofen	0.4	0.5	1.3	-0.6	-0.8	0.7	0.6	0.7	-0.0	-1.1
Medication: Allopurinol	0.3	0.4	0.9	-0.3	-0.5	0.3	-0.7	-0.6	-0.9	-0.6
Medication: Omeprazole	0.6	0.7	2.1	0.5	0.6	-0.6	1.4	-0.9	0.3	0.9
Medication: Seretide 50 evohaler	0.2	0.3	0.6	-0.3	-0.4	0.3	-0.8	-0.6	0.1	-0.7
Mean time to correctly identify matches	0.6	1.1	2.7	1.0	0.9	-1.0	0.9	0.8	1.6	0.9
Heart disease (mother)	0.1	0.1	0.7	0.1	-0.0	-0.0	-0.3	-0.9	-0.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	0.8	0.9	-0.8	0.9	0.4	0.7	0.5
Whole body fat mass	1.2	4.9	20.7	1.3	1.2	-1.5	-0.7	2.8	4.5	-0.1
Leg fat mass (right)	1.2	4.8	20.2	1.1	1.1	-1.4	-0.9	2.8	4.5	-0.2
Arm predicted mass (right)	0.6	3.1	15.0	0.9	1.0	-1.1	-0.9	1.7	3.9	0.1
Pulse rate, automated reading	0.3	1.1	1.9	1.2	1.2	-1.2	1.4	-0.5	-0.1	1.1
Alcohol intake frequency.	0.2	0.5	2.2	0.4	0.3	-0.5	0.2	0.7	1.5	0.0
Comparative height size at age 10	1.2	6.6	9.7	2.6	2.7	-2.6	1.4	2.5	3.1	2.8
Number of full sisters	0.5	0.7	1.1	0.9	0.9	-1.0	1.0	-0.2	0.4	0.8
Suffer from ‘nerves’	0.5	0.8	2.5	-0.9	-0.7	0.8	-1.6	-1.0	-0.6	-0.3
Overall health rating	0.6	1.3	4.0	1.2	1.3	-1.3	-0.1	0.0	2.0	0.5
Chest pain or discomfort	1.7	2.5	4.9	-1.7	-1.4	1.5	-2.2	-1.7	-0.5	-1.4
Had major operations	0.1	0.1	0.1	-0.3	-0.3	0.4	-0.3	-0.1	-0.3	-0.3
Age at last live birth	0.2	0.3	1.2	-0.4	-0.3	0.4	-0.3	-0.4	-1.1	0.2
Family relationship satisfaction	0.3	0.4	0.8	0.8	0.9	-0.7	0.1	0.4	0.0	0.8
Leg pain on walking	0.0	0.1	0.3	0.0	-0.0	-0.1	0.1	0.3	0.6	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.7	-1.1	-1.0	0.9	-1.2	-0.1	0.8	-1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.5	-0.8	0.5	-0.4	-0.4	-0.7	-0.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.9	-1.3	-1.3	1.4	-1.3	-0.8	-0.5	-0.2
Medication: Aspirin	0.2	0.2	0.6	-0.4	-0.3	0.3	-0.8	0.1	0.4	-0.6
Supplements: Vitamin C	0.4	0.4	0.8	0.6	0.7	-0.6	0.9	-0.0	0.5	0.9
Knee pain experienced in last month	0.1	0.2	0.7	-0.2	-0.4	0.1	-0.1	-0.2	0.8	-0.8
Hypertension (Self-reported)	0.1	0.3	1.1	0.0	-0.0	-0.1	-1.1	0.3	1.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.0	-0.4	-0.6	0.4	-1.0	0.3	-0.9	-0.6
Illnesses of father: Heart disease	0.9	1.2	2.2	-1.1	-0.9	1.1	-0.8	-1.2	-1.0	-1.5
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.6	0.7	-0.7	0.4	0.9	0.5	0.2
Smoking status: Previous	0.2	0.2	1.1	0.3	0.1	-0.5	0.4	1.0	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.6	0.8	0.8	-0.8	0.8	-0.9	-0.2	1.6
Whole body fat-free mass	0.7	3.9	16.5	1.4	1.5	-1.5	-0.1	2.0	4.1	0.7
Leg fat-free mass (right)	1.0	5.5	23.5	1.7	1.8	-1.9	0.4	2.1	4.8	0.9
Arm fat percentage (left)	1.1	4.5	17.8	1.5	1.4	-1.8	-0.1	2.6	4.2	0.2
Average weekly red wine intake	0.9	1.3	1.8	-1.3	-1.3	1.2	-1.3	-0.2	-1.0	-1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	-0.6	-0.6	0.8	-1.0	-0.2	-0.7	-0.9
Mood swings	0.2	0.4	0.9	0.4	0.8	-0.6	-0.5	0.4	1.0	0.2
Loneliness, isolation	0.5	0.7	1.3	-0.8	-0.7	0.7	-1.1	-1.0	-0.7	-0.6
Long-standing illness, disability or infirmity	0.4	0.6	2.3	-0.6	-0.4	0.3	-0.4	-0.5	0.9	-1.5
Ever had bowel cancer screening	0.4	0.5	0.7	-0.7	-0.8	0.5	-0.6	-0.4	0.8	-0.8
Diabetes diagnosed by doctor	0.1	0.2	1.0	0.0	0.0	-0.2	-0.5	0.5	-1.0	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.7	-1.1	-1.0	1.0	-1.2	-1.6	-0.8	-0.7
Friendships satisfaction	0.2	0.2	0.5	-0.5	-0.3	0.4	-0.7	-0.4	-0.4	-0.7
Qualifications: nursing, teaching	0.5	0.7	4.1	0.1	-0.1	-0.0	0.9	0.0	-2.0	0.3
Commuting to job workplace: Walk	0.1	0.1	0.6	0.1	0.1	-0.1	-0.3	0.8	0.4	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.4	0.4	-0.4	-0.0	0.2	0.5	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.4	0.5	-0.5	0.3	-0.4	-0.2	0.7
Medication for cholesterol	0.1	0.2	1.0	-0.2	0.0	0.2	0.1	0.3	-1.0	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.2	-1.1	-1.1	1.1	-0.4	-1.5	0.2	-1.0
Back pain experienced in last month	0.2	0.2	1.4	-0.2	-0.0	0.1	-1.2	-0.1	0.2	-0.3
Mineral and other dietary supplements	0.1	0.2	0.9	-0.2	-0.1	0.2	-0.9	-0.4	0.3	-0.3
Breast cancer (self-reported)	0.1	0.1	0.8	-0.0	0.1	-0.1	-0.3	0.1	0.9	-0.0
Asthma (self-reported)	1.0	2.1	3.2	1.7	1.6	-1.8	1.6	-0.1	1.2	1.3
Osteoporosis (self-reported)	0.1	0.2	0.5	0.2	0.2	-0.1	0.7	-0.1	-0.5	-0.6
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.6	-0.6	0.5	-0.5	0.5	0.2	-0.8
Medication: Aspirin	0.2	0.2	0.8	-0.4	-0.4	0.4	-0.9	-0.0	0.3	-0.6
Medication: Gliclazide	0.7	0.8	1.8	0.7	0.7	-0.7	0.0	1.3	1.3	0.8
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.0	-0.1	-0.1	0.0	0.4	-0.5	0.5
Smoking status: Current	0.1	0.2	0.6	0.1	0.4	-0.1	-0.1	-0.8	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	-0.8	-0.8	0.9	-0.9	0.4	-1.1	-0.1
Whole body water mass	0.7	3.8	15.8	1.4	1.5	-1.6	-0.0	1.9	4.0	0.7
Leg predicted mass (right)	1.0	5.3	22.8	1.7	1.7	-1.8	0.4	2.0	4.8	0.9
Arm fat mass (left)	1.2	4.9	21.8	1.3	1.3	-1.6	-0.5	2.5	4.7	-0.0
Number of self-reported non-cancer illnesses	0.2	0.3	1.2	-0.3	-0.3	0.2	-0.5	-1.1	-0.5	-0.6
Average weekly champagne plus white wine intake	0.5	0.8	2.6	0.8	0.9	-0.8	-0.2	0.4	1.6	0.5
Miserableness	0.2	0.4	0.8	0.6	0.7	-0.6	0.1	0.6	0.9	0.5
Guilty feelings	0.6	0.9	1.7	-1.0	-0.9	0.9	-1.3	-0.2	-0.9	-1.2
Wears glasses or contact lenses	0.5	0.6	1.8	-0.2	0.0	-0.0	-1.2	0.8	1.3	-0.5
Ever taken oral contraceptive pill	0.4	0.4	1.3	-0.6	-0.5	0.6	-1.1	-0.2	-0.2	-0.8
Hearing aid user	0.5	0.5	1.3	-0.5	-0.5	0.5	-0.4	-1.0	-1.2	-0.6
Mother’s age at death	0.5	0.7	2.1	0.7	0.7	-0.6	0.4	1.4	-0.8	0.6
Financial situation satisfaction	1.3	1.6	4.9	-1.2	-1.1	1.2	-1.0	-2.2	0.6	-0.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.1	-0.3	0.2	-0.2	0.5	0.2	-0.1
Commuting to job workplace: Public transport	6.1	7.3	13.2	2.6	2.8	-2.8	1.5	2.5	3.6	2.6
Eye problems/disorders: Glaucoma	1.6	1.9	3.0	1.6	1.7	-1.5	0.8	1.1	1.0	1.7
Medication: Blood pressure	0.4	0.7	3.9	-0.1	-0.2	0.1	-1.1	-0.2	2.0	-0.1
Pain type(s) experienced in last month: Hip pain	1.7	2.1	5.6	1.3	1.4	-1.5	1.2	2.4	1.4	0.4
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.1	1.0	1.0	-1.0	1.8	1.2	0.1	0.9
High cholesterol (Self-reported)	1.5	2.6	8.2	-1.5	-1.6	1.3	-2.9	-1.1	-0.3	-1.6
Medication: Bendroflumethiazide	2.4	3.6	4.7	2.0	2.0	-2.0	1.3	1.7	2.2	1.9
Medication: Paracetamol	0.0	0.1	0.3	0.1	0.2	-0.1	0.5	0.4	-0.1	-0.1
Medication: Lisinopril	0.1	0.2	0.7	-0.3	-0.4	0.4	-0.1	-0.0	0.9	0.0
Medication: Atorvastatin	0.5	0.7	1.3	-0.8	-0.8	0.9	-0.8	-0.2	-0.8	-1.1
Illnesses of father: High blood pressure	0.7	0.8	1.2	1.0	1.1	-1.0	0.9	0.5	1.0	0.5
Alcohol drinker status: Never	2.0	2.4	3.2	-1.6	-1.5	1.6	-1.8	-1.4	-1.2	-1.7
Ever smoked	0.2	0.3	1.7	-0.3	-0.2	-0.0	-0.2	0.4	-0.2	-1.3
Basal metabolic rate	0.8	4.7	19.6	1.5	1.6	-1.7	-0.1	2.2	4.4	0.7
Leg fat percentage (left)	0.9	3.3	14.7	0.5	0.5	-0.7	-1.5	2.2	3.8	-0.7
Arm fat-free mass (left)	0.7	3.3	16.3	0.8	0.9	-1.0	-1.2	1.8	4.0	-0.0
Number of operations (self-reported)	0.2	0.4	1.2	0.2	0.3	-0.2	-0.7	1.1	0.8	-0.1
Average weekly beer plus cider intake	2.1	3.1	7.9	1.9	1.9	-1.8	2.8	0.7	0.9	1.4
Irritability	0.7	1.2	3.5	0.7	0.7	-0.9	0.4	1.8	1.9	0.2
Risk taking	3.0	4.4	7.1	-2.1	-2.2	2.0	-1.6	-2.3	-1.6	-2.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.0	0.2	0.3	-0.2	0.2	1.0	-0.3	0.3
Fractured/broken bones in last 5 years	0.1	0.2	0.9	0.1	0.1	-0.0	-0.6	0.3	0.9	-0.2
Age started oral contraceptive pill	1.0	1.3	2.2	-1.2	-1.1	1.1	-1.0	-1.4	-0.4	-1.5
Diastolic blood pressure, automated reading	0.1	0.2	1.5	-0.2	-0.1	0.3	-0.1	-1.2	-0.0	-0.1
Ever depressed for a whole week	2.1	2.6	7.5	-1.7	-1.5	1.6	-2.7	-1.0	-0.7	-1.3
Unable to work because of sickness or disability	0.1	0.2	0.6	0.3	0.2	-0.2	0.7	0.2	-0.8	-0.2
Commuting to job workplace: Cycle	0.6	0.7	1.9	0.6	0.4	-0.5	1.4	0.9	-1.2	0.2
Myopia	1.7	2.5	6.0	1.4	1.4	-1.6	1.5	0.5	2.5	1.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.5	0.1	0.1	-0.1	1.2	-0.5	-1.2	0.6
Cholesterol lowering medication	0.9	1.3	2.6	-1.1	-1.3	1.1	-1.2	-1.1	0.1	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.8	-0.3	-0.3	0.3	0.2	-0.9	-0.0	0.0
Pain experienced in last month	0.1	0.1	0.4	-0.3	-0.4	0.5	-0.2	-0.0	-0.7	0.2
Supplements: Calcium	0.3	0.3	0.7	0.7	0.8	-0.6	0.9	0.4	-0.0	0.4
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	0.6	0.5	-0.5	-0.4	1.0	0.3	0.9
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.7	0.1	0.3	-0.0	0.3	0.2	0.8	0.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.9	0.8	0.8	-0.8	0.9	0.2	0.9	0.9
Heart disease (siblings)	0.4	0.4	0.9	-0.7	-0.6	0.5	-0.9	-0.4	-0.3	-0.9
Alcohol drinker status: Previous	1.4	1.6	2.7	1.2	1.3	-1.2	0.5	1.1	1.7	1.5
Pack years of smoking	1.4	2.1	7.0	-1.2	-1.1	1.3	-2.6	-0.3	1.3	-1.3
Impedance of whole body	0.3	1.5	7.5	0.3	0.2	-0.1	1.3	0.2	-2.7	1.0
Leg fat mass (left)	1.3	5.0	22.2	1.1	1.0	-1.3	-1.0	2.8	4.7	-0.3
Arm predicted mass (left)	0.7	3.3	15.4	1.0	1.1	-1.1	-0.9	1.9	3.9	0.1