Hub : Genes

UGP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1460	0.0570	2.8e-05	0.078	NA	0.067	NA	0.065	5.7e-07	NA	3.7e-06	NA	5.4e-06
2	GTEx	Artery Tibial	0.2353	0.0661	1.2e-08	0.058	NA	0.129	NA	0.110	2.3e-05	NA	2.6e-10	NA	6.0e-09
3	GTEx	Nerve Tibial	0.0598	0.0272	1.9e-03	0.011	NA	0.023	NA	0.021	5.0e-02	NA	8.7e-03	NA	1.2e-02
4	METSIM	Adipose	0.0316	0.0129	1.0e-04	0.023	0.022	0.014	0.021	0.030	1.9e-04	0.00023	2.7e-03	0.00038	2.2e-05
5	NTR	Blood	0.0144	0.0080	8.9e-03	0.012	0.003	0.001	0.004	0.007	6.5e-05	0.02900	1.0e-01	0.01200	1.6e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.0758	0.0307	1.3e-04	0.026	0.025	0.025	0.027	0.030	2.4e-04	0.00027	2.9e-04	0.00019	8.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.8	2.8	4.2	-1.8	-1.6	-2.0	-2.0	1.5	-0.9
Bipolar Disorder or Schizophrenia	0.5	1.1	2.8	-0.9	-1.7	-1.0	-0.9	0.5	-1.1
Depressed Affect (Nagel 2018)	0.7	1.6	3.1	1.5	1.8	1.2	1.4	-0.5	-0.5
Depression (Nagel 2018)	0.5	0.7	2.0	0.7	0.9	0.5	0.7	0.5	-1.4
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.7	-0.4	-2.2	-2.1	-1.5	0.7	1.3
Neuroticism (Nagel 2018)	0.7	1.6	3.1	1.3	1.2	1.0	1.5	0.7	-1.8
Schizophrenia (2018)	0.2	0.3	0.8	0.3	-0.9	0.3	0.5	-0.7	-0.6
Schizophrenia vs Biploar Disorder	0.5	0.7	1.1	0.8	0.8	1.0	0.9	0.4	1.1
Worry (Nagel 2018)	0.5	1.0	3.8	0.5	-0.0	0.6	0.7	2.0	-0.9
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.5	0.5	-0.1	-0.5	0.3	0.7
Alzheimer’s Disease (in father)	0.4	0.5	1.8	0.2	0.6	-0.3	-0.2	1.3	0.8
Alzheimer’s Disease (including proxy)	0.3	0.4	1.6	-0.5	0.0	-0.4	-0.6	0.5	1.3
Crohns Disease (2017)	0.4	0.9	1.7	1.1	1.3	0.9	1.0	0.6	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.5	0.2	0.4	0.3	-0.6	-0.0
Ulcerative Colitis (UC)	0.3	0.6	1.7	-0.4	-1.2	-0.3	-0.5	-1.3	-0.3
Major Depression (MDD)	0.4	0.5	2.3	-0.4	-0.5	-0.2	-0.2	1.5	0.1
Reaction Time	0.3	0.5	1.5	-0.4	0.6	-0.2	-0.5	0.8	1.2
Verbal and Numeric Reasoning (VNR)	0.4	1.1	5.1	-0.1	-0.7	-0.3	-0.8	0.3	2.3
Breast Cancer	0.5	1.1	3.9	0.6	1.4	0.1	0.5	-0.4	2.0
Ovarian Cancer	1.4	1.9	3.1	1.1	1.2	1.2	1.3	1.8	1.5
Prostate Cancer	8.0	11.2	23.3	3.4	-1.7	3.0	4.0	2.2	-4.8
Age at First Birth	0.4	0.6	1.8	0.6	-0.6	0.7	0.8	1.3	-0.5
Bipolar Disorder (2011)	3.0	2.9	8.5	-1.5	-1.0	-2.9	-2.0	1.2	-0.1
Body Mass Index (BMI) (2010)	2.1	2.9	5.1	2.1	1.8	2.2	2.3	-0.3	0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.5	-0.1	-0.2	-0.7	-0.2	0.3	-0.2
Crohns Disease (2012)	1.3	2.1	2.6	1.4	1.2	1.6	1.6	1.5	1.5
Mean Putamen Volume	0.8	0.9	2.4	-0.7	-1.4	-0.4	-0.4	-0.3	-1.6
Fasting Glucose	1.6	1.9	4.0	-1.0	-0.0	-1.6	-1.4	-2.0	1.5
HbA1C	0.8	0.9	2.9	-0.0	-1.7	0.0	-0.0	1.5	-0.5
HDL Cholesterol	2.6	4.4	8.9	-2.8	-1.3	-3.0	-2.8	0.6	0.2
LDL Cholesterol	2.1	3.3	5.9	1.5	1.7	2.4	2.3	-0.6	1.9
Lupus	0.8	1.3	2.8	1.7	0.0	1.5	1.1	0.1	1.1
Neuroticism (2016)	0.9	1.3	6.9	0.4	0.6	0.1	0.0	-0.5	-2.6
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.7	-0.6	0.2	0.5	0.4	-0.3
Rheumatoid Arthritis	2.5	3.4	9.1	2.1	1.1	3.0	2.1	1.0	-0.3
Schizophrenia (2014)	0.1	0.2	0.3	0.5	-0.1	0.2	0.4	0.3	-0.5
Triglycerides	0.8	1.4	2.5	1.4	1.1	1.6	1.6	0.4	-0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.9	1.0	0.2	0.0	0.4	0.1	-0.4
Ulcerative Colitis	0.1	0.1	0.4	0.2	-0.3	-0.1	0.1	-0.6	0.1
Blood Eosinophil Count	0.9	6.8	14.7	3.1	2.1	3.8	3.4	0.4	-0.0
Blood Platelet Count	0.8	8.9	20.9	2.9	4.6	3.5	2.9	0.4	1.7
Blood Red Count	0.0	0.3	0.7	-0.8	0.1	-0.7	-0.5	0.5	-0.1
Blood White Count	0.7	4.9	13.5	1.3	2.9	2.3	0.8	0.1	3.7
Heel T-Score	0.2	1.5	3.1	-1.2	-1.1	-0.5	-0.9	1.5	1.8
BMI	1.9	11.1	17.9	3.8	1.1	4.2	4.1	-3.1	-2.6
Height	0.2	4.4	8.1	2.7	1.1	2.0	2.9	1.9	-1.5
Waist Hip Ratio (WHR)	0.5	2.5	5.2	1.2	2.0	2.3	1.8	0.3	-0.8
Systolic Blood Pressure	3.0	14.9	32.1	-4.6	-2.9	-5.7	-5.0	-0.8	1.6
Smoking Status	2.0	4.8	10.0	-3.2	-1.0	-3.1	-2.7	-0.6	0.6
Allergy or Eczema	1.9	5.1	13.3	2.6	1.1	2.8	3.6	-0.7	-0.9
Cardiovascular Disease	0.9	3.0	17.2	-0.5	-0.5	-0.3	-0.5	-4.1	-0.1
Hypothyroidism (self reported)	0.3	0.7	2.7	0.6	-0.0	0.7	0.1	0.9	1.6
Respiratory disease	3.7	8.3	20.6	3.5	1.5	3.7	4.5	-0.8	0.1
Type 2 Diabetes (T2D) (2018)	1.0	1.9	9.7	-0.1	-0.5	0.0	-0.7	-3.1	-1.0
Lung FEV1/FVC ratio	0.1	0.4	1.6	-0.3	0.2	-0.8	-1.3	0.5	-0.2
Lung FVC	1.9	9.8	18.2	-3.7	-1.0	-4.3	-4.0	1.3	2.8
Neuroticism	0.8	1.8	5.9	1.0	0.6	0.7	1.4	1.1	-2.4
Chronotype (morning person)	1.4	3.2	8.6	0.4	-1.6	0.1	-0.0	2.8	-2.9
Hair Pigment	0.6	16.2	28.0	5.1	3.2	5.3	5.3	-2.0	-1.3
Tanning	0.7	9.2	17.8	-4.2	-1.5	-2.8	-4.1	1.0	3.1
Hand grip strength (left)	0.8	2.1	3.9	-0.8	-2.0	-1.6	-1.6	0.6	-1.6
Number of treatments/medications taken	0.4	0.7	2.8	0.4	-0.9	-0.1	0.1	-0.6	-1.7
Average weekly spirits intake	1.5	1.9	6.3	-1.0	0.1	-0.9	-0.8	-2.5	1.7
Sensitivity / hurt feelings	0.4	0.6	1.5	0.5	0.4	0.7	1.2	-1.0	-0.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	4.8	0.3	1.0	0.5	0.4	-0.5	-2.2
Hearing difficulty/problems: Yes	0.6	0.9	1.9	1.1	-1.4	0.6	1.1	-0.8	-0.4
Relative age of first facial hair	0.5	1.1	2.8	-0.2	-1.3	-1.7	-0.5	0.1	-1.2
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.9	1.4	0.6	1.7	1.6	0.5	-1.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.7	-0.6	-0.4	-1.3	-0.7	-0.6	1.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	0.5	-1.0	-0.4	0.2	0.1	-1.0
Systolic blood pressure, automated reading	0.5	1.6	4.2	-1.6	-0.3	-2.0	-1.5	-0.2	0.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.8	1.2	-0.1	1.1	1.2	-1.3	-1.0
Angina	1.6	2.1	4.0	2.0	1.1	1.9	1.8	-0.8	-0.1
Medication for hormone replacement therapy	3.2	3.6	6.6	-2.1	-2.2	-2.6	-2.3	-0.1	-0.1
Vitamin and mineral supplements	2.3	3.1	4.7	2.1	0.9	2.2	2.1	-1.0	1.8
Supplements: Zinc	0.9	0.9	2.2	-0.6	-0.8	-1.1	-0.8	0.5	-1.5
Medication: Co-codamol	0.8	0.9	2.7	0.6	1.1	0.6	0.6	-1.7	0.8
Medication: Metformin	1.7	2.4	9.6	-0.6	-1.4	-0.8	-1.3	-3.1	-0.6
Diabetes (father)	1.0	1.2	3.3	-1.5	0.5	0.0	-1.1	0.5	1.8
Diabetes (mother)	1.4	1.8	3.4	-1.2	-1.6	-0.5	-1.5	-1.8	-0.8
Severe depression (siblings)	1.2	1.4	4.5	-0.2	-1.2	-0.1	0.4	-1.5	-2.1
Pack years adult smoking proportion	1.0	1.5	2.9	-1.6	-0.0	-0.9	-1.6	-0.3	1.7
Impedance of leg (right)	0.2	1.2	2.5	-0.8	1.2	-1.3	-0.8	1.6	-0.4
Leg fat-free mass (left)	1.0	5.1	9.7	2.6	-0.2	3.1	2.6	-1.5	-2.2
Trunk fat percentage	1.3	5.3	8.8	2.9	1.3	2.5	3.0	-1.7	-1.9
Hand grip strength (right)	0.3	0.8	3.0	-0.2	-1.7	-1.2	-0.4	0.1	-0.2
Townsend deprivation index at recruitment	1.3	1.8	6.7	-1.1	-0.1	-0.9	-1.1	-2.6	1.0
Current tobacco smoking	0.5	0.9	2.6	-0.7	-0.1	-0.9	-1.1	-0.2	1.6
Average weekly fortified wine intake	1.3	1.5	4.3	-0.1	-1.5	-0.6	-0.4	2.1	-1.3
Maternal smoking around birth	3.1	4.4	9.9	-3.1	-0.8	-2.4	-2.7	1.5	0.4
Fed-up feelings	1.2	2.2	4.4	1.7	2.1	2.1	1.4	-0.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.4	-0.2	0.9	0.2	-0.2	0.6	-1.5
Relative age voice broke	0.3	0.4	0.6	0.8	0.6	-0.7	0.4	-0.8	0.6
Taking other prescription medications	0.2	0.3	0.5	0.7	-0.7	0.2	0.5	-0.7	-0.5
Age when periods started (menarche)	1.8	4.3	7.9	1.3	2.4	2.4	1.6	-1.4	2.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	-0.5	-0.6	-1.4	-1.1	-0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.3	-0.2	-1.5	-0.6	-0.2	1.0	-1.3
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	6.0	-0.5	1.6	0.5	-0.5	0.2	2.4
Qualifications: CSEs or equivalent	0.2	0.3	0.9	0.5	0.4	0.5	0.2	0.9	-0.5
Serious illness, injury or assault to yourself	2.1	2.6	5.9	1.3	1.6	2.4	2.3	-0.6	-0.1
High blood pressure	1.4	4.0	9.5	-1.4	-2.0	-2.2	-2.0	-3.1	-0.3
Hayfever, allergic rhinitis or eczema	1.6	3.4	8.6	1.9	1.6	2.3	2.9	-0.6	0.1
Multivitamins +/- minerals	2.6	3.3	5.9	-2.4	-1.0	-2.0	-2.4	0.4	-1.7
Stomach or abdominal pain in last month	0.9	1.1	3.0	-1.4	0.2	-0.9	-0.9	-1.7	-0.3
Supplements: Glucosamine	0.8	1.0	2.4	-1.3	-0.2	-1.1	-1.5	0.9	-0.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.5	-0.9	1.8	-0.1	-1.6	0.1	2.1
Medication: Atenolol	0.6	0.8	2.4	0.7	0.5	0.6	1.0	-1.6	0.2
Medication: Levothyroxine sodium	1.1	1.9	3.6	1.9	-1.0	1.2	1.2	1.9	-0.1
Sitting height	0.1	0.6	1.8	0.2	-0.9	0.3	0.3	1.3	-1.0
Chronic bronchitis/emphysema (father)	1.8	2.1	4.2	2.1	1.1	1.8	1.9	-0.3	0.7
High blood pressure (mother)	0.8	1.1	5.6	-0.1	-0.5	-0.2	-0.8	-2.4	0.4
Body mass index (BMI)	1.8	7.6	12.0	3.2	1.0	3.5	3.2	-3.1	-1.5
Impedance of leg (left)	0.5	2.3	5.3	-1.6	0.5	-2.3	-1.7	1.7	0.3
Leg predicted mass (left)	1.0	5.2	9.9	2.6	-0.1	3.1	2.6	-1.6	-2.2
Trunk fat mass	1.5	6.6	11.0	3.1	1.0	3.0	3.3	-2.0	-2.2
Waist circumference	2.6	9.7	17.1	3.8	1.8	4.1	3.9	-2.3	-1.7
Number of incorrect matches in round	0.4	0.6	2.0	-0.1	0.4	0.6	-0.1	-1.1	-1.4
Past tobacco smoking	4.0	7.3	15.4	3.9	1.7	3.6	3.5	0.7	-0.6
Alcohol usually taken with meals	0.6	1.0	4.6	-0.5	-0.3	-0.7	0.4	2.1	0.8
Nervous feelings	0.1	0.2	0.5	-0.3	-0.7	0.0	-0.5	0.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.5	-1.2	-0.5	-0.3	-0.8	0.7	-0.4
Hearing difficulty/problems with background noise	0.6	1.0	1.5	1.1	-0.5	1.1	1.2	0.5	-1.1
Hair/balding pattern: Pattern 2	2.3	3.0	5.6	2.4	0.8	1.9	2.0	1.3	-1.5
Had menopause	0.2	0.2	0.4	0.6	0.0	0.1	0.6	0.6	-0.6
Had other major operations	1.4	1.7	3.9	-0.8	-2.0	-1.3	-0.6	0.2	1.9
Forced vital capacity (FVC)	1.3	4.9	9.3	-3.0	-1.5	-3.0	-2.8	1.0	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	5.7	0.1	-2.4	-0.6	0.1	0.7	-1.5
Ever unenthusiastic/disinterested for a whole week	4.9	6.0	11.8	3.1	0.3	2.3	3.4	2.6	-1.5
Qualifications: None of the above	0.7	1.5	2.8	-1.3	-0.8	-1.1	-1.5	-1.7	0.7
Financial difficulties in last 2 years	1.2	1.6	4.1	1.5	-0.5	0.8	1.2	0.9	-2.0
Mouth/teeth dental problems	0.6	1.0	2.1	1.4	0.3	1.1	1.4	-0.7	-0.3
Heart attack	2.0	2.5	6.7	2.6	1.0	1.5	2.1	-1.0	0.0
Allergy	2.4	5.6	14.0	-2.8	-1.7	-2.8	-3.7	1.0	0.8
Pain all over the body in last month	1.8	1.9	3.9	1.2	1.9	2.0	1.4	-0.5	0.3
Diabetes (self-reported)	0.5	0.7	2.4	-0.0	-0.8	-0.4	-0.7	-1.5	-0.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	4.5	0.3	0.1	0.2	0.5	-2.1	0.5
Medication: Ramipril	0.2	0.3	0.6	0.7	0.7	0.1	-0.1	-0.8	-0.1
Medication: Simvastatin	1.7	2.5	6.1	1.8	0.3	1.7	1.6	-2.5	-0.7
Fluid intelligence score	0.5	1.0	4.2	-0.6	-0.7	-0.8	-0.5	0.1	2.0
Illnesses of siblings	0.7	1.0	3.4	-1.3	0.0	-0.9	-1.9	0.6	0.0
Neuroticism score	0.5	1.0	3.2	0.9	0.6	0.7	0.8	0.7	-1.8
Weight	1.6	7.7	12.6	3.3	0.6	3.6	3.5	-2.1	-2.4
Impedance of arm (right)	1.0	4.5	9.4	-2.0	-0.4	-2.8	-2.3	3.1	0.7
Arm fat percentage (right)	0.8	3.3	5.2	2.2	0.7	2.3	2.1	-1.9	-1.1
Trunk fat-free mass	0.7	4.0	10.0	2.0	-0.2	3.2	2.3	-1.3	-1.7
Hip circumference	1.9	8.3	14.5	3.8	0.9	3.4	3.8	-2.0	-2.2
Time employed in main current job	0.3	0.3	1.0	0.4	0.7	0.4	0.4	1.0	0.2
Alcohol intake versus 10 years previously	0.5	0.7	2.0	-0.4	0.4	0.7	0.1	-1.1	1.4
Father’s age at death	0.3	0.4	0.7	-0.6	0.7	-0.8	-0.7	0.8	-0.1
Worrier / anxious feelings	0.9	1.7	3.3	1.2	-0.7	0.8	1.1	1.8	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.5	-0.6	0.4	-0.5	-0.7	0.7	-0.1
Falls in the last year	1.7	2.3	5.9	1.9	1.0	2.4	1.6	-0.6	-0.6
Hair/balding pattern: Pattern 3	0.9	1.3	3.8	-1.5	-0.2	-0.5	-0.9	0.9	1.9
Number of live births	0.5	0.7	1.2	-1.1	0.2	-0.1	-1.1	-1.0	0.8
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	8.4	-2.8	-1.1	-2.9	-2.9	1.8	0.3
Pulse rate	1.1	1.9	3.8	-1.6	-1.1	-1.5	-2.0	-1.0	-0.4
Happiness	0.9	1.1	2.0	0.9	1.1	0.9	1.3	-1.4	-0.2
Noisy workplace	0.2	0.2	0.8	0.6	-0.1	0.9	0.2	-0.4	0.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.8	0.2	-0.7	0.0	-0.0	1.9	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.3	-0.8	1.8	-0.4	-0.9	-1.1	1.5
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	-0.4	0.3	-0.3	-0.6	-0.7	1.0
Asthma	1.5	2.9	6.7	2.1	0.9	2.1	2.6	-0.8	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.4	-0.7	0.2	-0.0	-0.5	0.3	-1.2
Medication: Cholesterol lowering	1.4	2.2	4.3	1.9	0.8	1.2	1.5	-2.1	-1.0
Depression (self-reported)	4.2	5.0	9.5	-2.0	-3.1	-2.0	-2.5	0.4	-2.4
Medication: Lansoprazole	1.3	1.5	2.5	-1.4	1.3	-1.6	-1.5	-0.6	0.6
Prospective memory result	1.8	2.2	4.8	1.6	0.0	1.5	1.6	-2.2	-0.9
Lung cancer (father)	4.0	4.7	7.7	-2.4	-2.4	-2.7	-2.8	1.1	0.1
Illnesses of mother	0.4	0.4	1.2	0.0	1.1	0.5	0.3	1.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	6.1	-2.0	-0.7	-2.5	-2.4	1.7	1.0
Pulse wave Arterial Stiffness index	1.1	1.3	2.5	-1.6	-0.9	-0.9	-1.6	0.9	0.4
Impedance of arm (left)	0.8	3.8	11.1	-1.4	-0.0	-2.5	-1.8	3.3	0.8
Arm fat mass (right)	1.4	5.8	8.8	2.9	0.6	3.0	2.9	-2.3	-1.9
Trunk predicted mass	0.7	3.9	9.9	1.9	-0.1	3.1	2.3	-1.2	-1.7
Standing height	0.2	1.6	5.0	0.4	-0.7	0.6	0.9	1.8	-2.2
Length of working week for main job	1.2	1.3	3.4	1.4	0.0	1.1	1.2	1.9	-0.2
Exposure to tobacco smoke at home	0.4	0.5	1.0	-0.0	-1.0	0.1	-0.0	-1.0	-1.0
Breastfed as a baby	0.6	0.8	1.0	1.0	0.8	0.9	1.0	-1.0	0.4
Tense / ‘highly strung’	2.1	3.5	8.2	-2.0	-2.1	-1.6	-2.9	1.1	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.2	-1.0	-0.7	-0.9	-1.2	0.5	-1.5
Hair/balding pattern: Pattern 4	1.5	3.6	9.9	1.9	3.1	1.9	1.9	-0.7	0.8
Birth weight of first child	0.4	0.7	2.6	0.5	-0.0	0.6	0.5	1.6	-0.9
Peak expiratory flow (PEF)	1.6	3.6	8.3	-2.8	-1.3	-2.9	-2.0	0.1	0.4
Pulse wave reflection index	0.7	0.8	1.8	-1.3	-0.6	-1.0	-1.2	0.2	0.1
Ever highly irritable/argumentative for 2 days	2.4	2.9	5.5	-1.8	-2.4	-1.7	-2.0	-0.2	-1.2
Loud music exposure frequency	1.4	1.6	4.0	1.1	1.2	1.5	2.0	-0.5	-0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	4.2	-0.5	0.5	0.1	-0.8	2.0	1.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.8	-0.1	-0.2	-0.0	0.1	0.1	-0.9
Blood clot in the leg (DVT)	3.1	4.0	6.6	2.3	1.8	2.0	2.6	-0.8	-1.9
Medication: Paracetamol	0.6	1.1	2.3	-1.0	0.9	-0.8	-1.2	1.5	-0.2
Headache pain in last month	3.0	5.2	9.3	-2.8	-1.9	-2.7	-3.0	-1.5	1.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	5.8	-1.1	-0.1	-0.3	-0.5	2.4	1.7
Glaucoma (self-reported)	0.1	0.2	0.5	-0.4	-0.2	0.1	-0.0	0.7	0.6
Gout (self-reported)	1.0	1.3	4.1	-1.0	-0.4	-1.2	-1.1	-2.0	-0.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.9	1.3	-0.2	1.0	0.7	1.5	2.0
Medication: Amlodipine	2.5	3.4	8.2	-1.4	-1.9	-2.1	-1.6	-2.9	-0.1
Medication: Ventolin 100micrograms inhaler	3.9	5.0	10.0	3.2	2.4	2.0	2.8	0.5	1.6
Birth weight	1.5	3.3	5.6	2.0	1.8	2.4	1.8	0.2	-1.8
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	-0.2	0.5	0.3	-0.4	0.7	0.3
High blood pressure (siblings)	1.1	1.5	6.8	0.1	-2.6	-0.5	0.7	-0.6	-1.1
Forced vital capacity (FVC), Best measure	0.5	1.8	3.8	-1.7	-0.4	-1.9	-1.7	0.8	0.7
Body fat percentage	1.4	5.7	8.9	2.9	1.5	2.7	3.0	-2.1	-1.6
Leg fat percentage (right)	1.9	7.1	10.2	2.9	1.8	3.0	3.2	-2.7	-1.9
Arm fat-free mass (right)	1.1	5.6	10.0	2.5	0.3	3.2	2.8	-1.8	-2.6
Exposure to tobacco smoke outside home	0.7	1.0	2.8	-0.8	0.2	-1.2	-0.9	-1.7	0.2
Comparative body size at age 10	2.0	5.6	10.8	3.3	-0.4	3.0	2.6	1.4	-2.1
Number of full brothers	0.6	0.7	1.5	-1.0	-1.2	-0.7	-0.6	-1.0	-0.1
Worry too long after embarrassment	0.8	1.4	4.1	1.3	0.3	1.0	0.9	0.9	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.0	-1.4	-1.3	-1.4	-1.3	0.4	-1.1
Wheeze or whistling in the chest in last year	1.1	2.0	4.2	1.1	0.3	2.0	1.5	-2.1	-0.1
Number of children fathered	0.2	0.3	0.5	0.2	0.5	-0.3	0.7	-0.6	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.6	-1.0	-1.6	-1.6	-0.6	1.0	-1.4
Age at first live birth	1.7	2.9	6.1	1.4	1.7	2.5	2.2	1.4	-0.2
Pulse wave peak to peak time	1.3	1.5	2.9	1.6	1.1	1.1	1.7	-0.9	-0.6
Health satisfaction	1.1	1.5	3.9	0.5	2.0	1.6	0.4	0.2	-1.4
Shortness of breath walking on level ground	1.3	1.5	3.6	1.9	0.8	1.5	1.5	-0.2	-0.6
Qualifications: College or University degree	2.0	6.3	9.7	3.0	2.0	3.0	3.1	2.2	-1.0
Eye problems/disorders: None of the above	0.3	0.4	0.8	-0.6	0.4	-0.4	-0.7	0.9	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	-0.6	-0.6	-0.5	-0.5	0.7	0.6
Emphysema/chronic bronchitis	0.6	0.7	2.3	-0.0	0.9	0.3	0.6	-0.6	1.5
Medication for pain relief, constipation, heartburn	0.4	0.7	1.5	0.5	-0.3	0.3	1.2	0.7	1.2
Neck or shoulder pain in last month	2.1	3.0	4.2	-1.8	-1.9	-1.6	-1.7	-2.0	1.1
Medication: Blood pressure	0.6	1.0	4.5	0.8	-0.3	-0.4	-0.3	-2.1	-0.8
Angina (self-reported)	1.2	1.6	2.8	1.7	1.0	1.6	1.5	-1.0	-0.1
Migraine (self-reported)	1.3	1.6	5.3	-0.9	-2.3	-0.2	-0.0	-1.7	0.6
Medication: Ibuprofen	1.0	1.2	2.9	-0.9	-0.3	-0.7	-0.7	1.4	-1.7
Medication: Allopurinol	0.9	1.3	4.3	-0.7	-0.6	-1.2	-1.0	-2.1	-0.2
Medication: Omeprazole	1.1	1.3	5.6	-0.1	-1.0	0.3	-0.7	-2.4	-0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.3	-0.4	-0.2	0.6	-0.2	0.0
Mean time to correctly identify matches	0.3	0.7	3.2	-0.1	0.7	0.2	0.0	0.4	1.8
Heart disease (mother)	1.2	1.5	5.4	1.6	-0.0	0.9	2.3	0.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.8	-1.2	-1.7	-1.5	-1.2	-1.1	-0.1
Whole body fat mass	1.8	7.4	11.5	3.2	1.1	3.3	3.4	-2.6	-2.0
Leg fat mass (right)	1.9	7.3	10.9	2.9	1.2	3.3	3.0	-2.9	-2.2
Arm predicted mass (right)	1.2	6.0	10.7	2.7	0.3	3.3	2.9	-1.9	-2.5
Pulse rate, automated reading	0.9	3.0	6.4	-1.4	-2.5	-2.0	-2.0	-1.2	-0.8
Alcohol intake frequency.	0.6	1.4	4.8	0.3	-0.0	1.4	0.8	-2.2	-1.0
Comparative height size at age 10	0.5	3.0	12.0	-0.6	-2.0	-0.9	-0.7	0.4	-3.5
Number of full sisters	0.4	0.5	2.2	-0.3	-0.4	-0.4	-0.7	-1.5	-0.3
Suffer from ‘nerves’	0.1	0.2	0.5	-0.7	-0.1	0.3	-0.5	-0.3	0.2
Overall health rating	0.6	1.3	4.5	0.1	1.3	1.2	0.2	-2.1	-0.3
Chest pain or discomfort	0.7	0.9	2.8	0.6	1.7	0.9	1.1	0.7	0.3
Had major operations	0.2	0.2	0.7	-0.4	0.1	0.5	-0.0	-0.8	-0.3
Age at last live birth	0.2	0.3	0.9	-1.0	0.5	0.3	-0.3	-0.0	-0.4
Family relationship satisfaction	0.3	0.4	0.9	0.8	-0.2	-0.1	0.8	-0.9	0.2
Leg pain on walking	2.0	2.5	4.4	1.4	1.6	1.7	2.1	1.0	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	5.8	1.8	2.4	2.0	2.3	-0.1	-0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	-0.1	0.1	0.5	0.1	-0.5	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	-0.1	-0.0	-0.6	-0.6	-0.6	0.8
Medication: Aspirin	1.1	1.5	2.6	1.2	0.9	1.6	1.2	-1.4	-0.5
Supplements: Vitamin C	1.0	1.2	4.4	-0.4	-0.9	-1.1	-0.6	-0.6	-2.1
Knee pain experienced in last month	0.5	0.7	2.2	0.6	1.5	0.9	0.7	0.5	-0.3
Hypertension (Self-reported)	1.3	3.7	10.2	-1.1	-2.1	-1.8	-1.6	-3.2	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.3	0.1	1.8	0.7	0.1	-0.2	1.5
Illnesses of father: Heart disease	0.8	1.1	4.5	1.1	-2.1	0.1	0.9	0.0	-0.1
Illnesses of siblings: Diabetes	1.2	1.5	2.7	1.6	1.4	1.1	1.3	-0.9	-0.7
Smoking status: Previous	3.0	4.4	9.2	-3.0	-1.9	-2.8	-2.4	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	4.8	0.0	-0.4	0.1	0.3	2.2	-1.2
Whole body fat-free mass	0.8	4.7	9.8	2.3	-0.2	3.1	2.5	-1.6	-2.0
Leg fat-free mass (right)	0.6	3.4	6.7	2.1	-0.6	2.6	2.1	-1.3	-1.8
Arm fat percentage (left)	1.0	3.9	6.2	2.5	0.9	2.5	2.5	-1.8	-1.1
Average weekly red wine intake	0.4	0.5	2.0	-0.1	-0.2	-0.4	0.4	1.4	1.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.0	-1.7	-0.3	-0.5	-1.6	0.3	-0.3
Mood swings	0.4	0.7	1.4	0.1	1.0	-0.7	-0.5	-1.0	-1.2
Loneliness, isolation	0.7	0.9	3.6	0.7	0.5	0.7	0.8	-1.9	-0.0
Long-standing illness, disability or infirmity	1.6	2.4	7.2	1.7	0.2	1.8	2.7	-0.3	-1.0
Ever had bowel cancer screening	0.8	0.9	1.9	-1.4	-0.2	-1.3	-1.2	-0.6	0.3
Diabetes diagnosed by doctor	0.5	0.8	3.3	-0.2	-0.7	-0.3	-0.8	-1.8	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	4.4	-0.3	1.2	0.7	0.2	0.3	2.1
Friendships satisfaction	0.8	1.0	2.6	0.7	0.8	0.8	1.1	-1.6	0.6
Qualifications: nursing, teaching	0.6	0.9	3.0	1.2	0.5	1.7	0.7	-0.4	0.0
Commuting to job workplace: Walk	0.2	0.2	0.4	0.4	-0.2	-0.4	0.7	0.6	-0.5
Eye problems/disorders: Cataract	0.6	0.7	1.6	1.1	-0.6	0.9	0.4	-1.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	2.4	-1.4	-0.7	-1.3	-1.3	1.1	-1.5
Medication for cholesterol	1.1	1.7	3.3	1.4	1.4	1.1	1.8	1.3	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.8	0.0	0.4	-0.9	0.1	1.2	-1.7
Back pain experienced in last month	1.2	1.7	6.7	0.2	0.2	1.4	0.8	-1.1	-2.6
Mineral and other dietary supplements	1.3	1.7	4.8	1.3	-0.5	0.3	1.4	-2.2	1.3
Breast cancer (self-reported)	1.6	1.9	3.5	-0.9	-1.7	-1.3	-1.2	-0.9	-1.9
Asthma (self-reported)	1.4	2.8	6.6	2.1	0.8	2.1	2.6	-0.9	0.2
Osteoporosis (self-reported)	0.8	1.0	2.3	1.1	-0.4	-0.4	0.8	1.5	-1.3
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.5	-0.4	0.3	0.8	0.5	-0.5
Medication: Aspirin	1.3	1.6	3.2	1.3	1.1	1.8	1.3	-1.4	-0.5
Medication: Gliclazide	0.1	0.2	0.5	0.3	0.4	0.5	0.2	0.3	0.7
Illnesses of father: None of the above (group 1)	1.4	1.7	3.9	-2.0	1.0	-1.1	-1.8	-0.9	0.1
Smoking status: Current	0.5	0.8	2.0	-0.7	0.0	-0.9	-1.2	0.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	6.3	-1.6	-1.1	-2.5	-2.4	1.4	1.6
Whole body water mass	0.8	4.6	9.7	2.3	-0.2	3.1	2.5	-1.6	-2.0
Leg predicted mass (right)	0.6	3.3	6.4	2.0	-0.7	2.5	2.0	-1.3	-1.8
Arm fat mass (left)	1.4	5.8	9.1	2.9	0.6	3.0	3.0	-2.2	-1.8
Number of self-reported non-cancer illnesses	0.5	0.8	2.0	0.7	-0.7	0.3	1.0	-1.4	-0.8
Average weekly champagne plus white wine intake	1.3	1.8	6.4	-0.2	-1.0	-1.1	-0.0	1.6	-2.5
Miserableness	0.1	0.2	0.5	0.7	-0.2	0.2	0.4	-0.5	-0.0
Guilty feelings	0.8	1.2	5.0	0.5	-0.4	0.0	0.6	-1.1	-2.2
Wears glasses or contact lenses	1.6	1.9	4.5	1.8	0.3	1.5	2.1	0.9	-0.4
Ever taken oral contraceptive pill	3.6	4.1	8.5	-2.2	-1.7	-2.9	-2.4	1.4	0.7
Hearing aid user	0.7	0.8	2.5	-0.1	-0.5	1.6	1.1	-0.3	0.7
Mother’s age at death	0.9	1.1	2.8	-0.7	-1.7	-1.2	-0.3	0.5	-1.2
Financial situation satisfaction	2.3	2.9	7.0	1.8	1.4	2.0	2.6	-0.6	-1.0
Tinnitus: Yes, now most or all of the time	1.5	1.8	5.1	0.7	-0.8	0.5	1.4	-1.5	-2.2
Commuting to job workplace: Public transport	4.4	5.3	9.5	2.9	2.3	3.1	2.8	0.3	-1.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.2	-0.2	-0.1	0.1	0.4	0.5
Medication: Blood pressure	0.9	1.7	3.9	-1.5	-1.1	-0.9	-1.4	-2.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.9	-0.6	-1.4	-0.2	-0.7	-0.1	-1.4
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.2	-0.2	1.1	0.2	-0.0	1.8	-0.1
High cholesterol (Self-reported)	1.7	3.0	5.5	1.8	1.1	2.0	1.9	-2.4	-0.5
Medication: Bendroflumethiazide	0.2	0.4	1.8	0.0	1.4	-0.4	-0.2	-0.3	0.0
Medication: Paracetamol	0.5	0.7	1.9	-0.7	0.4	-0.9	-1.0	1.4	-0.2
Medication: Lisinopril	0.4	0.5	1.8	-0.3	-0.5	0.1	-0.6	-0.7	-1.4
Medication: Atorvastatin	0.3	0.4	0.9	0.9	0.1	-0.2	0.9	-0.5	-0.8
Illnesses of father: High blood pressure	0.4	0.5	2.2	0.2	-0.4	0.2	0.3	0.7	-1.5
Alcohol drinker status: Never	0.3	0.3	1.2	-0.2	-0.6	0.1	0.4	-1.1	-0.4
Ever smoked	4.4	7.7	15.2	-3.9	-1.8	-3.7	-3.7	-0.8	0.5
Basal metabolic rate	1.0	5.7	11.4	2.6	0.1	3.4	2.9	-1.8	-2.2
Leg fat percentage (left)	1.5	5.3	7.8	2.5	1.5	2.5	2.8	-2.7	-1.4
Arm fat-free mass (left)	1.2	6.0	11.0	2.6	0.2	3.3	2.9	-2.1	-2.3
Number of operations (self-reported)	1.7	2.5	4.9	-1.8	-2.2	-1.4	-1.7	-1.5	0.3
Average weekly beer plus cider intake	0.7	1.0	1.4	-0.6	0.9	-1.0	-1.1	-1.2	1.2
Irritability	1.2	2.0	7.1	-0.5	-0.7	-1.0	-0.2	1.8	-2.7
Risk taking	4.5	6.5	16.8	-2.0	-4.1	-3.5	-2.0	-0.4	-1.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	-1.0	0.1	-0.2	-0.1	0.5	-0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.3	-0.8	0.5	0.4	0.2	-0.7
Age started oral contraceptive pill	3.6	4.5	9.4	2.2	-0.6	1.3	2.6	1.8	-3.1
Diastolic blood pressure, automated reading	0.8	2.5	5.9	-1.3	-1.4	-2.4	-1.7	-1.2	-1.0
Ever depressed for a whole week	2.1	2.6	5.6	1.9	0.7	2.4	2.2	0.5	-0.8
Unable to work because of sickness or disability	0.4	0.5	1.0	-1.0	0.4	-0.3	-1.0	-1.0	0.1
Commuting to job workplace: Cycle	1.2	1.5	4.8	0.6	1.6	0.9	0.4	-0.2	2.2
Myopia	0.6	0.9	4.5	0.1	-0.4	-0.6	0.3	-0.4	-2.1
Vascular/heart problems diagnosed by doctor	0.9	2.5	10.9	0.5	1.3	1.1	1.1	3.3	0.0
Cholesterol lowering medication	0.3	0.5	2.0	0.2	0.2	0.8	-0.2	-1.4	0.3
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	9.0	-0.5	-0.4	-0.1	-1.3	-3.0	-0.2
Pain experienced in last month	0.4	0.7	2.5	0.1	-0.2	0.1	0.6	1.6	1.2
Supplements: Calcium	5.3	5.8	7.6	-2.3	-2.7	-2.6	-1.9	2.1	-2.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	0.4	-0.4	0.6	0.9	-1.1	-1.0
Heart attack/myocardial infarction (self-reported)	1.6	2.1	5.2	2.3	0.8	1.2	1.8	-1.4	0.1
Deep venous thrombosis (DVT) (self-reported)	3.0	3.8	6.6	2.2	1.8	1.9	2.6	-0.6	-2.0
Heart disease (siblings)	1.0	1.2	2.9	0.6	0.7	0.8	1.7	-1.2	1.1
Alcohol drinker status: Previous	2.4	2.7	7.9	-0.4	-1.5	-0.7	-0.3	-2.3	-2.8
Pack years of smoking	0.9	1.3	3.5	-1.4	0.1	-0.7	-1.3	-0.2	1.9
Impedance of whole body	0.7	3.4	7.5	-1.6	0.4	-2.7	-1.7	2.7	0.3
Leg fat mass (left)	1.7	6.7	9.7	2.8	1.1	3.1	3.0	-2.9	-2.1
Arm predicted mass (left)	1.2	5.9	10.0	2.4	-0.1	3.2	2.8	-2.1	-2.6