Hub : Genes

UNC13B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.4640 0.1110 0.00280 0.000 NA -0.007 NA -0.008 0.32000 NA 0.65000 NA 0.74000
2 GTEx Esophagus Mucosa 0.0620 0.0310 0.00840 0.005 NA -0.003 NA -0.003 0.15000 NA 0.60000 NA 0.60000
3 GTEx Skin Sun Exposed Lower leg 0.2130 0.0640 0.00003 0.001 NA 0.038 NA 0.004 0.25000 NA 0.00037 NA 0.13000
4 GTEx Thyroid 0.0950 0.0360 0.00290 0.008 NA 0.022 NA 0.011 0.07000 NA 0.00810 NA 0.04400
5 METSIM Adipose 0.0348 0.0162 0.00300 0.003 0.012 0.008 0.011 0.007 0.11000 0.0047 0.02200 0.007 0.02300
6 TCGA Thyroid Carcinoma 0.0420 0.0270 0.00510 0.038 0.021 0.016 NA 0.030 0.00012 0.0036 0.00900 NA 0.00061

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.6 0.9 0.0 0.7 -0.9 1.0 -0.7 0.8
Bipolar Disorder or Schizophrenia 1.8 4.4 8.7 0.0 -2.2 -2.0 1.1 -2.9 2.9
Depressed Affect (Nagel 2018) 0.9 2.0 5.3 0.0 -0.8 -1.0 -2.2 0.1 -2.3
Depression (Nagel 2018) 1.3 2.0 5.3 0.0 -1.7 -2.3 -0.6 -1.8 0.6
Intelligence (Savage-Jansen 2018) 0.5 1.5 5.1 0.0 2.3 -0.1 0.9 1.7 -0.7
Neuroticism (Nagel 2018) 1.0 2.3 7.4 0.0 -0.9 -0.9 -2.7 0.1 -2.2
Schizophrenia (2018) 2.8 5.7 11.5 0.0 -3.4 -1.7 0.8 -3.1 3.1
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 0.0 -1.0 1.0 0.2 -0.0 1.0
Worry (Nagel 2018) 0.2 0.4 1.0 0.0 -0.7 -0.2 -1.0 -0.7 -0.4
Alzheimer’s Disease (in mother) 0.4 0.5 2.0 0.0 0.1 -0.0 0.5 0.8 -1.4
Alzheimer’s Disease (in father) 0.4 0.4 1.1 0.0 0.2 0.4 1.1 -0.8 0.8
Alzheimer’s Disease (including proxy) 0.3 0.4 0.9 0.0 0.3 0.5 0.9 0.4 -0.9
Crohns Disease (2017) 0.5 1.0 3.0 0.0 -1.7 -0.4 0.0 -0.4 1.7
Irritable Bowel Disease (IBD) 0.6 1.5 3.9 0.0 -1.9 -0.6 0.8 -0.8 2.0
Ulcerative Colitis (UC) 0.4 0.7 1.5 0.0 -1.2 -0.1 0.9 -0.6 1.2
Major Depression (MDD) 1.4 1.7 5.6 0.0 -1.5 -2.4 0.0 -1.4 0.7
Reaction Time 0.3 0.6 1.5 0.0 -1.2 0.9 0.8 -0.6 0.5
Verbal and Numeric Reasoning (VNR) 1.2 2.9 9.3 0.0 3.1 0.5 0.8 2.2 -1.5
Breast Cancer 0.8 2.0 4.9 0.0 0.0 -0.3 -2.0 1.8 -2.2
Ovarian Cancer 0.6 0.8 2.1 0.0 0.2 -0.4 -1.0 1.1 -1.4
Prostate Cancer 0.8 1.1 5.2 0.0 -0.7 0.2 2.3 -0.6 0.6
Age at First Birth 0.4 0.6 1.8 0.0 0.6 -0.7 0.8 -0.3 -1.3
Bipolar Disorder (2011) 3.1 3.0 5.5 0.0 -0.9 -1.7 1.9 -2.3 2.4
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 0.0 0.9 0.2 -0.9 0.5 -0.1
Coronary Artery Disease (CAD) 0.3 0.4 1.8 0.0 -0.1 -0.6 0.0 -0.0 1.4
Crohns Disease (2012) 0.4 0.6 2.6 0.0 0.0 -1.6 0.5 -0.2 0.8
Mean Putamen Volume 0.8 0.9 3.4 0.0 -0.7 0.6 0.5 -1.1 1.8
Fasting Glucose 0.2 0.2 0.6 0.0 -0.2 0.4 -0.7 0.8 0.3
HbA1C 2.2 2.4 5.0 0.0 2.0 -0.6 -0.8 2.1 -2.2
HDL Cholesterol 1.1 1.9 5.4 0.0 -1.6 -2.3 -1.2 -0.2 -1.3
LDL Cholesterol 1.0 1.6 4.4 0.0 -1.2 -0.6 1.0 -1.6 2.1
Lupus 0.8 1.3 3.4 0.0 -1.6 -0.1 1.9 -0.8 1.0
Neuroticism (2016) 2.1 3.0 6.1 0.0 -0.7 -1.8 -2.3 1.7 -2.5
Primary Biliary Cirrhosis 3.2 4.6 11.4 0.0 2.0 3.4 -2.0 2.8 -0.6
Rheumatoid Arthritis 0.7 1.0 1.5 0.0 1.1 0.9 -1.2 0.9 -1.2
Schizophrenia (2014) 1.3 2.8 5.8 0.0 -1.6 -2.4 0.3 -1.8 2.2
Triglycerides 0.1 0.2 0.4 0.0 0.5 0.6 -0.2 -0.5 0.5
Type 2 Diabetes (T2D) (2012) 1.2 1.3 2.8 0.0 0.3 0.6 1.7 -1.7 1.4
Ulcerative Colitis 0.5 0.7 2.7 0.0 -0.3 -0.6 0.7 -0.7 1.6
Blood Eosinophil Count 0.7 5.7 20.6 0.0 4.5 0.4 -1.7 2.7 -1.7
Blood Platelet Count 0.6 6.8 23.7 0.0 -4.9 2.3 -0.4 -2.7 2.1
Blood Red Count 0.3 2.7 7.8 0.0 -2.8 -0.6 -1.3 -2.0 1.5
Blood White Count 0.5 3.7 10.6 0.0 -2.8 -0.2 -3.3 -2.0 0.1
Heel T-Score 0.2 1.9 5.4 0.0 2.0 -1.4 2.3 0.6 -0.1
BMI 0.2 1.0 4.2 0.0 -0.2 -1.1 -2.1 0.3 0.5
Height 0.3 5.3 28.7 0.0 -0.9 -0.9 0.7 -5.4 1.1
Waist Hip Ratio (WHR) 0.5 2.2 8.3 0.0 1.4 -2.9 -0.6 1.6 -0.1
Systolic Blood Pressure 0.7 3.6 7.6 0.0 -2.4 -1.5 0.8 -2.4 2.8
Smoking Status 0.7 1.6 6.7 0.0 -1.1 -0.9 -0.3 0.9 -2.6
Allergy or Eczema 0.4 1.0 4.1 0.0 2.0 1.0 0.2 0.8 -0.1
Cardiovascular Disease 0.1 0.5 1.2 0.0 -0.9 -1.1 -0.1 -0.2 0.9
Hypothyroidism (self reported) 0.3 0.8 1.7 0.0 -1.3 -0.8 0.2 -1.2 0.9
Respiratory disease 0.8 1.8 5.3 0.0 2.3 0.0 -1.6 1.2 -1.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.3 0.0 1.0 0.4 -0.2 -0.4 1.1
Lung FEV1/FVC ratio 0.3 1.4 3.7 0.0 -1.9 -0.4 1.6 -1.2 0.6
Lung FVC 0.1 0.8 2.7 0.0 -1.1 -0.4 1.6 -0.4 0.6
Neuroticism 0.6 1.5 4.1 0.0 -1.3 -0.6 -2.0 -0.5 -1.5
Chronotype (morning person) 1.1 2.6 7.5 0.0 -2.7 -0.6 -1.5 -2.0 1.4
Hair Pigment 0.0 0.4 1.6 0.0 -1.3 0.2 -0.7 0.4 -0.6
Tanning 0.1 1.6 5.5 0.0 0.3 -0.8 -1.0 1.5 -2.3
Hand grip strength (left) 0.5 1.2 2.5 0.0 1.5 -0.4 -0.7 1.3 -1.6
Number of treatments/medications taken 0.2 0.4 0.8 0.0 -0.8 -0.9 0.8 0.3 -0.2
Average weekly spirits intake 0.8 1.0 2.8 0.0 -0.6 0.2 1.7 -1.3 1.1
Sensitivity / hurt feelings 0.5 0.8 2.0 0.0 -1.3 0.1 -1.0 -1.4 -0.5
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.3 0.0 -1.4 -1.5 -1.0 -0.1 -0.5
Hearing difficulty/problems: Yes 0.2 0.2 1.2 0.0 -1.1 0.1 0.3 0.4 -0.1
Relative age of first facial hair 1.2 2.5 8.8 0.0 2.0 0.1 0.3 3.0 -1.3
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 2.4 0.0 -0.0 -0.9 1.6 -0.8 0.5
Ever used hormone-replacement therapy (HRT) 2.2 2.7 8.5 0.0 -1.6 0.6 2.9 -1.6 1.6
Ever had hysterectomy (womb removed) 0.4 0.5 1.9 0.0 -0.2 -0.0 0.7 -0.5 1.4
Systolic blood pressure, automated reading 0.4 1.1 3.1 0.0 -1.4 -0.5 -0.1 -1.2 1.8
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.0 0.0 0.8 0.2 -1.4 1.2 -0.2
Angina 1.4 1.8 6.4 0.0 -1.2 -0.9 2.5 -0.7 1.4
Medication for hormone replacement therapy 0.4 0.5 1.4 0.0 -0.6 -1.2 -0.4 -0.2 -0.9
Vitamin and mineral supplements 0.3 0.5 1.4 0.0 0.4 1.2 -0.1 0.6 0.9
Supplements: Zinc 0.7 0.7 2.4 0.0 0.1 -0.9 1.6 -0.8 0.9
Medication: Co-codamol 1.3 1.5 4.8 0.0 0.5 -0.3 -2.2 1.2 -1.5
Medication: Metformin 0.6 0.8 1.9 0.0 -0.7 -1.1 -1.1 -1.4 0.1
Diabetes (father) 0.1 0.1 0.5 0.0 0.2 -0.4 0.7 0.3 0.1
Diabetes (mother) 0.7 0.9 3.1 0.0 -0.2 -0.3 -1.8 1.4 -0.5
Severe depression (siblings) 0.5 0.6 2.7 0.0 -0.7 -1.6 -0.1 -0.6 -0.1
Pack years adult smoking proportion 0.5 0.8 2.1 0.0 -1.1 1.1 -1.5 0.4 -0.5
Impedance of leg (right) 0.7 3.5 12.7 0.0 2.1 1.7 3.6 0.6 0.5
Leg fat-free mass (left) 0.5 2.4 5.9 0.0 -0.7 -1.9 -2.4 -2.2 -0.1
Trunk fat percentage 0.3 1.1 2.3 0.0 1.3 0.9 -1.0 1.5 -1.1
Hand grip strength (right) 0.4 1.1 4.1 0.0 2.0 -0.2 -0.0 0.9 -1.1
Townsend deprivation index at recruitment 0.3 0.4 1.6 0.0 0.5 0.0 0.0 1.2 -0.6
Current tobacco smoking 0.7 1.1 3.5 0.0 -0.7 -1.3 -0.3 0.9 -1.9
Average weekly fortified wine intake 0.3 0.3 0.9 0.0 0.7 -1.0 -0.1 0.7 0.0
Maternal smoking around birth 0.6 0.9 3.1 0.0 -1.1 0.8 -1.8 0.3 -0.6
Fed-up feelings 0.9 1.7 5.6 0.0 0.2 -1.3 -2.4 0.6 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 3.1 0.0 -1.6 -1.8 -1.2 -0.4 0.7
Relative age voice broke 1.8 2.8 7.0 0.0 2.2 1.3 -0.9 2.6 -1.6
Taking other prescription medications 0.8 1.2 3.0 0.0 -1.7 -1.7 0.5 -0.9 0.4
Age when periods started (menarche) 0.6 1.3 5.4 0.0 -0.1 -0.0 -2.3 1.1 -1.3
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.7 0.0 -0.3 -1.6 0.0 -0.8 1.1
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 12.2 0.0 0.7 -1.3 3.5 -0.5 0.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.3 0.0 0.7 1.1 1.0 0.9 -0.0
Qualifications: CSEs or equivalent 1.5 2.0 5.0 0.0 -2.0 -1.4 0.2 -2.2 1.1
Serious illness, injury or assault to yourself 0.9 1.1 3.4 0.0 -1.3 0.3 0.9 -0.8 1.9
High blood pressure 0.3 0.9 4.5 0.0 -2.1 -0.7 -0.5 0.1 0.5
Hayfever, allergic rhinitis or eczema 0.4 1.0 4.0 0.0 2.0 1.1 0.7 0.0 0.4
Multivitamins +/- minerals 1.3 1.7 3.7 0.0 -1.7 -1.9 0.8 -1.7 -0.1
Stomach or abdominal pain in last month 2.6 3.2 6.3 0.0 -1.6 -1.5 2.1 -1.9 2.5
Supplements: Glucosamine 0.9 1.2 2.7 0.0 1.6 1.6 0.9 0.9 -0.5
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 1.6 0.0 0.3 1.3 0.9 0.3 0.7
Medication: Atenolol 0.9 1.1 1.7 0.0 -1.1 -1.2 0.9 1.2 -1.3
Medication: Levothyroxine sodium 0.7 1.2 3.3 0.0 -1.8 -0.1 0.8 -1.4 1.1
Sitting height 0.3 2.1 10.2 0.0 -0.4 -0.8 0.2 -3.2 1.2
Chronic bronchitis/emphysema (father) 0.2 0.3 1.1 0.0 0.3 1.1 0.3 0.3 0.6
High blood pressure (mother) 0.1 0.1 0.6 0.0 0.1 0.0 -0.8 0.1 -0.1
Body mass index (BMI) 0.3 1.2 4.9 0.0 0.7 0.0 -2.2 1.2 -0.6
Impedance of leg (left) 0.8 3.7 12.8 0.0 2.1 1.8 3.6 1.3 0.5
Leg predicted mass (left) 0.5 2.6 5.6 0.0 -0.8 -2.0 -2.4 -2.4 0.1
Trunk fat mass 0.2 1.0 2.8 0.0 1.2 0.3 -1.7 1.0 -0.9
Waist circumference 0.4 1.5 3.7 0.0 1.8 -0.2 -1.9 1.3 -0.6
Number of incorrect matches in round 0.7 1.2 3.0 0.0 -1.2 -0.0 0.9 -1.3 1.7
Past tobacco smoking 0.3 0.5 1.2 0.0 0.5 0.5 -1.1 -0.5 1.1
Alcohol usually taken with meals 0.3 0.5 1.5 0.0 -0.8 -0.6 -1.2 0.3 0.6
Nervous feelings 0.1 0.3 0.6 0.0 0.1 0.7 -0.8 -0.1 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.4 0.0 -0.4 -1.6 0.1 -0.3 0.3
Hearing difficulty/problems with background noise 0.5 0.9 2.2 0.0 -1.5 -0.9 1.3 -0.3 0.5
Hair/balding pattern: Pattern 2 0.5 0.6 1.7 0.0 0.7 1.3 0.6 0.8 0.8
Had menopause 0.5 0.7 2.0 0.0 -0.2 1.4 1.1 -0.3 0.8
Had other major operations 0.4 0.5 1.5 0.0 -0.2 -0.3 1.2 -0.6 1.0
Forced vital capacity (FVC) 0.4 1.6 5.0 0.0 0.4 0.0 1.8 -2.2 1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 11.7 0.0 1.2 -0.5 3.4 -0.4 0.1
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.4 0.0 0.6 -0.0 1.5 1.3 -0.6
Qualifications: None of the above 1.1 2.4 6.9 0.0 0.8 1.3 -1.3 1.8 -2.6
Financial difficulties in last 2 years 0.5 0.7 1.7 0.0 -0.8 -1.0 -0.1 -1.3 1.1
Mouth/teeth dental problems 0.9 1.4 4.4 0.0 1.3 -0.0 -1.4 2.1 -0.6
Heart attack 1.3 1.6 5.4 0.0 0.7 -0.2 -1.0 2.3 -1.7
Allergy 0.3 0.8 3.4 0.0 -1.8 -0.4 0.6 -0.7 0.7
Pain all over the body in last month 0.5 0.5 2.0 0.0 1.0 0.1 -0.0 0.5 -1.4
Diabetes (self-reported) 0.5 0.8 2.2 0.0 -0.0 -0.5 -0.4 -1.5 1.4
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 11.0 0.0 1.8 3.3 0.6 1.3 -0.6
Medication: Ramipril 0.2 0.3 1.1 0.0 0.4 -0.2 -0.4 1.0 0.6
Medication: Simvastatin 0.2 0.2 0.6 0.0 0.6 -0.8 -0.1 0.5 0.5
Fluid intelligence score 1.2 2.5 8.1 0.0 2.8 0.9 0.0 2.1 -1.2
Illnesses of siblings 0.8 1.1 3.8 0.0 -0.7 -0.4 -2.0 0.7 -1.3
Neuroticism score 0.9 1.8 7.3 0.0 -0.3 -1.0 -2.7 0.2 -1.5
Weight 0.1 0.7 3.0 0.0 0.9 -0.4 -1.7 -0.5 -0.1
Impedance of arm (right) 0.1 0.6 2.4 0.0 0.7 0.9 1.6 -0.5 0.0
Arm fat percentage (right) 0.4 1.7 3.9 0.0 1.4 0.7 -2.0 1.6 -1.0
Trunk fat-free mass 0.3 2.0 5.2 0.0 -0.2 -1.9 -1.7 -2.3 0.5
Hip circumference 0.2 1.0 2.2 0.0 1.3 1.2 -1.5 0.1 -1.0
Time employed in main current job 2.3 2.6 10.8 0.0 3.3 1.4 0.9 1.4 -0.6
Alcohol intake versus 10 years previously 1.7 2.5 9.2 0.0 2.2 0.9 0.2 3.0 -0.5
Father’s age at death 0.6 0.8 2.1 0.0 1.5 0.4 0.8 1.3 -0.7
Worrier / anxious feelings 0.7 1.4 3.7 0.0 -1.3 -1.9 -1.0 -1.3 0.4
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 4.6 0.0 -2.1 -0.8 -0.2 -1.5 1.3
Falls in the last year 0.4 0.6 1.6 0.0 -1.2 0.5 0.6 -1.0 0.6
Hair/balding pattern: Pattern 3 0.6 0.9 2.8 0.0 -0.1 -0.9 0.9 -1.7 0.8
Number of live births 0.4 0.6 1.6 0.0 -1.3 0.2 0.5 -1.0 0.8
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 7.0 0.0 -0.1 -0.7 2.6 -2.6 1.5
Pulse rate 1.5 2.6 5.3 0.0 0.8 0.9 -2.3 2.1 -2.1
Happiness 0.4 0.5 1.3 0.0 0.7 -0.1 0.3 -1.1 1.1
Noisy workplace 0.1 0.1 0.2 0.0 0.2 -0.3 0.4 0.2 -0.3
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.8 0.0 0.6 -0.3 1.3 -0.4 0.7
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 4.2 0.0 2.0 -0.9 -0.0 1.0 -1.2
Mouth/teeth dental problems: Dentures 0.2 0.4 1.1 0.0 -0.5 -0.4 -0.7 -1.0 -0.5
Asthma 0.3 0.7 2.1 0.0 1.5 0.1 -0.9 -0.1 -1.0
Medication: Ibuprofen (e.g. Nurofen) 2.5 3.2 9.9 0.0 1.7 1.5 -0.4 2.0 -3.2
Medication: Cholesterol lowering 0.2 0.3 0.6 0.0 -0.5 -0.8 0.6 -0.4 0.6
Depression (self-reported) 0.6 0.7 1.8 0.0 -0.3 -1.1 -0.1 1.2 -1.3
Medication: Lansoprazole 0.3 0.4 1.5 0.0 -1.2 -0.5 -0.3 0.4 -0.5
Prospective memory result 0.3 0.3 1.0 0.0 -1.0 -0.2 -0.1 -1.0 -0.1
Lung cancer (father) 0.5 0.5 1.9 0.0 -0.4 1.0 -1.4 0.0 -0.2
Illnesses of mother 0.0 0.0 0.0 0.0 0.0 -0.2 -0.1 -0.0 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 4.6 0.0 0.8 -0.1 2.1 -1.7 1.0
Pulse wave Arterial Stiffness index 0.7 0.9 2.2 0.0 -0.8 0.5 1.3 -1.5 0.7
Impedance of arm (left) 0.3 1.3 4.8 0.0 1.0 1.3 2.2 -0.0 -0.4
Arm fat mass (right) 0.2 0.9 3.7 0.0 1.0 -0.2 -1.9 0.5 -0.4
Trunk predicted mass 0.3 2.0 5.2 0.0 -0.1 -1.9 -1.6 -2.3 0.6
Standing height 0.3 3.0 14.7 0.0 0.2 -1.0 0.8 -3.8 1.2
Length of working week for main job 0.1 0.2 0.3 0.0 -0.5 -0.6 -0.5 0.1 -0.3
Exposure to tobacco smoke at home 0.2 0.2 0.9 0.0 0.7 0.1 0.9 -0.2 0.2
Breastfed as a baby 0.1 0.1 0.4 0.0 0.5 0.6 0.3 -0.0 -0.0
Tense / ‘highly strung’ 0.5 0.9 2.9 0.0 -1.7 -0.9 -0.2 -1.3 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 9.4 0.0 -1.5 -3.1 -0.2 -0.5 -0.1
Hair/balding pattern: Pattern 4 0.4 0.9 2.3 0.0 0.1 -0.1 -1.3 1.3 -1.5
Birth weight of first child 0.5 0.8 2.1 0.0 -0.8 0.5 0.4 -1.4 1.4
Peak expiratory flow (PEF) 0.7 1.6 7.1 0.0 1.3 -0.3 2.7 -0.9 0.3
Pulse wave reflection index 0.8 1.0 2.6 0.0 0.5 -0.4 1.4 -1.6 1.0
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.8 0.0 1.5 0.6 0.0 1.1 -1.7
Loud music exposure frequency 0.3 0.4 1.4 0.0 0.5 -0.3 -0.2 0.5 -1.2
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.6 0.0 0.8 0.7 1.1 -0.0 1.9
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.7 0.0 0.6 1.4 2.2 -0.5 0.5
Blood clot in the leg (DVT) 0.2 0.3 0.7 0.0 0.7 0.1 -0.2 0.6 -0.9
Medication: Paracetamol 1.1 1.9 5.2 0.0 1.6 2.3 1.5 0.9 0.7
Headache pain in last month 0.4 0.7 2.6 0.0 -1.6 -0.1 -0.5 -0.5 1.1
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.4 0.0 0.6 0.8 0.7 -1.2 0.5
Glaucoma (self-reported) 0.4 0.5 1.7 0.0 -1.1 0.2 0.2 -1.3 -0.1
Gout (self-reported) 0.2 0.2 1.1 0.0 -0.1 -0.3 -1.0 -0.3 -0.2
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.3 0.0 -1.1 0.0 0.7 -1.4 1.5
Medication: Amlodipine 0.5 0.6 1.8 0.0 -1.1 0.1 -1.3 0.9 -0.1
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.9 0.0 1.1 0.1 -1.4 0.5 -0.4
Birth weight 0.2 0.4 1.1 0.0 1.1 0.3 0.8 0.5 0.2
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.8 0.0 1.3 0.3 0.1 -0.1 0.2
High blood pressure (siblings) 0.2 0.3 1.0 0.0 -0.0 -0.2 0.7 0.0 1.0
Forced vital capacity (FVC), Best measure 0.2 0.6 1.7 0.0 0.8 0.5 1.0 -1.3 0.1
Body fat percentage 0.4 1.5 3.4 0.0 1.7 1.1 -1.0 1.9 -1.0
Leg fat percentage (right) 0.6 2.1 5.7 0.0 2.4 1.5 -0.4 2.0 -0.7
Arm fat-free mass (right) 0.3 1.3 3.4 0.0 -0.2 -1.8 -1.4 -1.5 0.2
Exposure to tobacco smoke outside home 1.5 2.1 5.1 0.0 1.9 0.9 -0.8 2.3 -1.5
Comparative body size at age 10 0.3 0.7 2.0 0.0 0.8 -0.9 -0.2 1.0 -1.4
Number of full brothers 0.3 0.3 0.9 0.0 0.4 1.0 -0.5 0.7 0.4
Worry too long after embarrassment 2.2 3.8 10.6 0.0 0.9 -1.1 -3.3 1.6 -2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 7.1 0.0 -0.7 -2.7 0.1 -1.4 0.6
Wheeze or whistling in the chest in last year 0.6 1.1 2.2 0.0 1.4 -0.9 -0.1 1.5 -1.2
Number of children fathered 0.7 0.8 1.7 0.0 -1.3 -1.3 0.6 -1.1 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.5 0.0 -1.6 -0.6 -0.5 0.4 -0.6
Age at first live birth 0.2 0.3 0.8 0.0 0.7 0.1 0.9 0.2 -0.6
Pulse wave peak to peak time 0.5 0.6 1.6 0.0 0.9 -0.4 -1.2 1.0 -0.4
Health satisfaction 1.3 1.8 4.0 0.0 1.7 2.0 1.4 1.4 0.0
Shortness of breath walking on level ground 1.2 1.4 4.4 0.0 -0.2 1.3 -1.1 1.1 -2.1
Qualifications: College or University degree 0.1 0.2 0.4 0.0 0.3 -0.6 -0.6 0.5 0.5
Eye problems/disorders: None of the above 0.4 0.5 1.3 0.0 0.6 0.9 1.2 -0.5 0.5
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.6 0.0 -1.3 -0.9 0.3 -0.7 -0.1
Emphysema/chronic bronchitis 2.9 3.2 10.1 0.0 1.8 0.9 -1.8 3.2 -1.5
Medication for pain relief, constipation, heartburn 0.4 0.8 2.0 0.0 -0.8 -1.4 -0.6 -1.1 0.4
Neck or shoulder pain in last month 1.9 2.7 9.0 0.0 -3.0 -1.3 1.0 -1.7 1.3
Medication: Blood pressure 0.5 0.8 2.2 0.0 -0.9 -0.8 -1.2 1.5 -0.2
Angina (self-reported) 1.5 2.0 7.2 0.0 -1.0 -1.0 2.7 -0.9 1.5
Migraine (self-reported) 0.9 1.2 3.9 0.0 0.1 -0.7 -0.2 -1.6 2.0
Medication: Ibuprofen 2.7 3.3 10.7 0.0 1.2 1.2 -0.8 2.3 -3.3
Medication: Allopurinol 0.4 0.6 2.6 0.0 0.5 0.1 -1.6 0.1 -0.8
Medication: Omeprazole 0.1 0.1 0.3 0.0 0.5 0.1 0.2 0.2 -0.0
Medication: Seretide 50 evohaler 0.3 0.4 1.4 0.0 -0.7 -0.1 -0.7 -0.1 -1.2
Mean time to correctly identify matches 0.3 0.6 3.1 0.0 -0.3 1.8 0.2 0.5 -0.3
Heart disease (mother) 0.7 0.8 3.2 0.0 0.1 1.8 1.0 -0.8 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.9 0.0 0.5 -0.5 1.7 1.1 -1.5
Whole body fat mass 0.2 1.0 2.7 0.0 1.3 0.4 -1.6 0.9 -0.7
Leg fat mass (right) 0.3 1.2 2.9 0.0 1.7 0.5 -1.6 1.1 -0.6
Arm predicted mass (right) 0.3 1.3 3.3 0.0 -0.2 -1.8 -1.4 -1.6 0.1
Pulse rate, automated reading 0.3 1.1 5.4 0.0 -0.5 -1.0 -2.3 -0.1 -0.2
Alcohol intake frequency. 0.1 0.2 1.2 0.0 1.1 -0.4 0.1 0.3 -0.1
Comparative height size at age 10 0.7 3.7 12.4 0.0 -0.3 -2.6 1.1 -3.5 1.4
Number of full sisters 0.5 0.6 1.5 0.0 -1.0 -0.7 -1.2 0.7 0.0
Suffer from ‘nerves’ 0.0 0.1 0.1 0.0 -0.1 0.4 -0.4 0.1 -0.3
Overall health rating 0.0 0.1 0.5 0.0 -0.0 -0.2 -0.1 0.7 -0.2
Chest pain or discomfort 2.8 4.1 9.4 0.0 -2.9 -0.9 1.0 -3.1 2.2
Had major operations 0.7 0.8 3.0 0.0 1.7 0.9 -0.4 0.6 0.6
Age at last live birth 0.1 0.1 0.4 0.0 0.0 -0.6 0.4 -0.2 -0.1
Family relationship satisfaction 0.2 0.3 1.1 0.0 1.1 0.4 0.4 0.4 -0.1
Leg pain on walking 0.7 0.9 2.2 0.0 0.4 1.3 1.1 1.5 -0.4
Qualifications: NVQ or HND or HNC or equivalent 2.4 2.9 6.2 0.0 -2.5 -1.7 0.2 -2.5 1.4
Commuting to job workplace: Car/motor vehicle 1.6 1.8 8.3 0.0 -0.1 -2.9 1.5 -0.7 0.0
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.4 0.0 -0.1 0.3 -0.5 -0.5 -0.6
Medication: Aspirin 0.2 0.2 0.6 0.0 0.3 0.2 0.8 0.6 0.5
Supplements: Vitamin C 0.4 0.4 1.7 0.0 -0.2 -0.2 -0.5 0.8 -1.3
Knee pain experienced in last month 1.8 2.7 5.4 0.0 1.8 2.3 -1.4 2.0 -1.4
Hypertension (Self-reported) 0.4 1.2 5.2 0.0 -2.3 -0.9 -0.6 -0.2 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.4 0.0 1.3 -0.5 1.5 -1.0 0.2
Illnesses of father: Heart disease 1.2 1.6 6.1 0.0 -1.2 -0.3 2.5 -1.5 0.3
Illnesses of siblings: Diabetes 1.2 1.5 3.9 0.0 -0.4 -1.3 1.2 -2.0 1.3
Smoking status: Previous 0.2 0.2 0.6 0.0 -0.6 -0.5 0.4 -0.1 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 4.0 0.0 -1.2 -2.0 0.1 -1.2 -0.3
Whole body fat-free mass 0.4 2.2 4.7 0.0 -0.5 -2.0 -2.0 -2.2 0.3
Leg fat-free mass (right) 0.5 2.6 6.8 0.0 -0.9 -2.0 -2.6 -2.0 -0.1
Arm fat percentage (left) 0.4 1.8 3.4 0.0 1.6 0.7 -1.7 1.9 -1.2
Average weekly red wine intake 0.2 0.3 1.2 0.0 -0.0 1.1 0.5 -0.1 -0.4
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.7 0.0 0.2 -0.9 -0.8 0.1 0.7
Mood swings 1.3 2.3 5.6 0.0 -1.8 -2.4 -1.5 -1.0 -1.3
Loneliness, isolation 2.0 2.7 10.0 0.0 -0.0 -0.6 -3.2 1.6 -1.8
Long-standing illness, disability or infirmity 0.0 0.0 0.1 0.0 -0.0 0.0 -0.3 0.0 0.1
Ever had bowel cancer screening 0.5 0.6 1.9 0.0 -0.1 -0.9 0.9 0.2 1.4
Diabetes diagnosed by doctor 0.8 1.3 3.1 0.0 -0.7 -0.9 -0.6 -1.8 1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.8 0.0 -1.2 -1.7 -0.8 -1.0 -0.2
Friendships satisfaction 0.5 0.6 2.3 0.0 0.7 0.3 -1.5 0.8 0.2
Qualifications: nursing, teaching 0.4 0.6 2.1 0.0 1.2 0.3 0.1 -0.2 1.4
Commuting to job workplace: Walk 1.8 2.0 8.6 0.0 0.6 2.9 -0.9 0.7 -1.2
Eye problems/disorders: Cataract 0.9 1.0 2.6 0.0 0.2 -1.1 -1.6 1.0 -1.2
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 3.1 0.0 -1.7 -1.2 1.5 -1.8 1.2
Medication for cholesterol 0.6 0.9 2.2 0.0 1.1 1.5 -0.9 0.8 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 5.2 0.0 -1.3 -2.3 0.6 -0.4 0.0
Back pain experienced in last month 0.7 1.1 3.0 0.0 -0.4 -0.2 1.4 -1.7 1.2
Mineral and other dietary supplements 0.6 0.9 2.1 0.0 0.4 0.0 -1.5 1.4 -1.0
Breast cancer (self-reported) 0.6 0.7 2.0 0.0 -0.4 0.9 0.7 -0.9 1.4
Asthma (self-reported) 0.3 0.6 2.5 0.0 1.6 0.0 -0.8 -0.2 -0.8
Osteoporosis (self-reported) 0.8 1.0 3.1 0.0 -0.7 -1.8 -1.1 0.2 -1.0
Osteoarthritis (self-reported) 0.3 0.5 1.4 0.0 -0.2 0.9 1.2 0.3 -0.5
Medication: Aspirin 0.2 0.2 0.7 0.0 0.1 0.1 0.8 0.7 0.5
Medication: Gliclazide 2.5 2.8 8.4 0.0 -1.3 -2.9 -0.8 -2.2 1.0
Illnesses of father: None of the above (group 1) 1.9 2.4 8.6 0.0 1.3 -0.1 -2.9 1.2 -1.6
Smoking status: Current 0.4 0.7 2.5 0.0 -0.6 -0.9 0.1 0.7 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.5 0.0 -0.1 0.3 1.6 -0.7 -0.0
Whole body water mass 0.4 2.1 4.5 0.0 -0.4 -2.0 -2.0 -2.1 0.2
Leg predicted mass (right) 0.5 2.6 6.5 0.0 -1.0 -2.0 -2.6 -2.0 -0.0
Arm fat mass (left) 0.2 0.9 3.4 0.0 1.1 -0.2 -1.8 0.8 -0.6
Number of self-reported non-cancer illnesses 0.3 0.5 2.3 0.0 -0.4 -0.7 1.5 -0.3 0.2
Average weekly champagne plus white wine intake 1.4 1.9 3.9 0.0 -0.2 1.1 -1.7 1.8 -2.0
Miserableness 0.2 0.3 1.1 0.0 -1.1 0.0 -0.6 0.3 -0.2
Guilty feelings 1.8 2.7 7.1 0.0 -0.3 -2.0 -1.9 1.2 -2.7
Wears glasses or contact lenses 0.8 0.9 4.1 0.0 -0.6 2.0 -1.0 0.2 0.1
Ever taken oral contraceptive pill 2.9 3.2 8.2 0.0 0.0 0.7 -2.2 2.9 -2.4
Hearing aid user 0.5 0.6 2.6 0.0 -1.6 0.2 -0.7 -0.4 -0.2
Mother’s age at death 0.5 0.6 2.3 0.0 -1.5 0.1 -0.3 -0.7 -1.0
Financial situation satisfaction 0.7 0.8 2.2 0.0 1.5 1.1 -0.0 1.2 -0.1
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.7 0.0 -0.4 -0.9 -0.0 -0.5 -0.2
Commuting to job workplace: Public transport 1.1 1.3 7.3 0.0 0.7 2.7 -0.1 0.1 -0.3
Eye problems/disorders: Glaucoma 0.5 0.6 2.5 0.0 -1.6 -0.3 -0.2 -0.5 -0.7
Medication: Blood pressure 0.3 0.5 2.6 0.0 -1.6 -0.2 -0.1 0.0 0.7
Pain type(s) experienced in last month: Hip pain 2.0 2.5 10.0 0.0 1.0 3.2 -0.9 1.6 -0.6
Supplements: Fish oil (including cod liver oil) 1.1 1.5 5.3 0.0 -0.7 -0.5 1.1 -2.3 1.2
High cholesterol (Self-reported) 0.7 1.2 2.8 0.0 -0.9 -1.1 1.1 -1.2 1.7
Medication: Bendroflumethiazide 0.3 0.4 1.2 0.0 -1.1 -0.9 0.3 -0.0 0.5
Medication: Paracetamol 0.9 1.4 3.7 0.0 1.4 1.9 0.9 1.4 0.0
Medication: Lisinopril 0.3 0.4 1.7 0.0 -1.3 -0.3 -0.9 0.0 0.3
Medication: Atorvastatin 2.1 2.6 4.8 0.0 -1.6 -0.8 1.8 -2.1 2.2
Illnesses of father: High blood pressure 0.6 0.7 2.5 0.0 -0.4 -0.6 1.1 -0.1 1.6
Alcohol drinker status: Never 1.5 1.8 4.5 0.0 0.1 -0.6 -2.1 1.4 -2.0
Ever smoked 0.6 1.0 2.5 0.0 -0.8 -0.7 1.2 0.9 -1.6
Basal metabolic rate 0.3 1.8 4.0 0.0 -0.1 -1.8 -2.0 -1.8 0.1
Leg fat percentage (left) 0.6 2.3 5.9 0.0 2.2 1.6 -0.5 2.4 -0.6
Arm fat-free mass (left) 0.2 1.1 2.3 0.0 0.2 -1.5 -1.5 -1.4 0.3
Number of operations (self-reported) 0.2 0.2 0.6 0.0 -0.0 -0.6 0.8 0.0 0.6
Average weekly beer plus cider intake 0.4 0.6 2.0 0.0 -1.4 0.2 -0.9 -0.9 0.3
Irritability 1.0 1.8 3.9 0.0 -2.0 -1.7 -1.0 -1.4 -1.0
Risk taking 0.5 0.7 2.5 0.0 -1.6 -1.0 -0.4 0.0 0.7
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.2 0.0 0.5 0.6 0.8 0.1 1.1
Fractured/broken bones in last 5 years 2.6 3.4 13.7 0.0 -2.1 -3.7 -0.6 -1.3 -0.7
Age started oral contraceptive pill 2.0 2.6 6.4 0.0 2.5 1.5 -1.4 2.0 -0.8
Diastolic blood pressure, automated reading 0.0 0.1 0.5 0.0 0.2 0.1 -0.7 0.2 0.5
Ever depressed for a whole week 0.5 0.6 1.4 0.0 -0.2 -1.2 0.9 1.1 -0.5
Unable to work because of sickness or disability 0.6 0.7 3.0 0.0 -0.5 -1.7 -0.1 -0.9 0.5
Commuting to job workplace: Cycle 0.4 0.5 1.8 0.0 -0.9 -0.5 -1.3 0.0 -0.6
Myopia 1.0 1.5 4.8 0.0 -1.2 -0.8 1.1 -2.2 1.1
Vascular/heart problems diagnosed by doctor 0.3 0.8 3.4 0.0 1.9 0.6 0.5 -0.6 -0.3
Cholesterol lowering medication 0.9 1.3 4.9 0.0 0.0 -0.6 1.0 -1.1 2.2
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.0 0.5 -0.0 0.4 0.3 0.0
Pain experienced in last month 0.2 0.3 1.0 0.0 0.8 -1.0 -0.3 -0.2 -0.6
Supplements: Calcium 1.8 2.0 5.0 0.0 -1.8 -1.4 1.3 -2.2 0.4
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.0 -0.3 -0.4 -0.2 -0.2 0.5
Heart attack/myocardial infarction (self-reported) 1.4 1.7 6.4 0.0 0.6 -0.4 -0.9 2.5 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.5 0.0 0.7 0.2 0.2 0.7 -0.7
Heart disease (siblings) 0.9 1.1 3.7 0.0 1.9 1.0 1.4 0.3 -0.1
Alcohol drinker status: Previous 0.2 0.2 1.1 0.0 0.4 0.4 0.2 -0.1 -1.0
Pack years of smoking 0.8 1.1 2.8 0.0 -0.7 1.7 -1.4 1.0 -0.5
Impedance of whole body 0.4 2.2 8.9 0.0 1.4 1.4 3.0 0.5 -0.0
Leg fat mass (left) 0.3 1.2 2.4 0.0 1.5 0.6 -1.5 1.2 -0.6
Arm predicted mass (left) 0.2 1.0 2.9 0.0 0.1 -1.3 -1.7 -1.2 0.1