Hub : Genes

UNC5B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.1630	0.0540	3.8e-03	-0.001	NA	-0.002	NA	0.002	3.8e-01	NA	5.4e-01	NA	2.0e-01
2	METSIM	Adipose	0.0635	0.0265	8.3e-03	-0.002	0.006	0.001	0.006	-0.002	1.0e+00	3.3e-02	2.4e-01	3.6e-02	7.8e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.3023	0.0427	2.1e-13	0.137	0.156	0.137	0.175	0.143	3.0e-17	1.6e-19	3.6e-17	5.8e-22	6.0e-18
4	TCGA	Breast Invasive Carcinoma	0.0370	0.0142	2.2e-04	0.002	0.009	-0.001	NA	-0.001	1.2e-01	5.5e-03	5.9e-01	NA	8.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.2	1.9	6.2	-0.8	-0.9	0.1	-2.5
Bipolar Disorder or Schizophrenia	0.5	1.1	2.5	1.6	-0.1	0.9	-1.1
Depressed Affect (Nagel 2018)	1.3	2.7	5.5	-1.5	1.7	2.4	0.0
Depression (Nagel 2018)	0.7	1.1	3.8	-0.2	2.0	0.7	-0.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	0.4	-0.3	0.4	-0.7
Neuroticism (Nagel 2018)	0.8	1.8	3.2	-1.4	1.4	1.8	0.5
Schizophrenia (2018)	1.1	2.2	7.2	2.7	0.6	1.0	0.6
Schizophrenia vs Biploar Disorder	3.2	4.2	9.5	3.1	0.7	-1.1	2.4
Worry (Nagel 2018)	0.5	1.0	2.0	-0.9	1.0	0.5	1.4
Alzheimer’s Disease (in mother)	1.4	1.7	3.1	-0.4	-1.8	1.7	0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.7	0.4	0.5	-0.5
Alzheimer’s Disease (including proxy)	0.6	0.8	2.8	-0.2	-0.3	1.7	0.5
Crohns Disease (2017)	0.5	1.1	3.2	-1.8	-0.0	-1.0	0.0
Irritable Bowel Disease (IBD)	0.2	0.4	1.3	-1.2	-0.1	0.6	0.2
Ulcerative Colitis (UC)	0.2	0.4	1.0	0.2	0.1	1.0	0.7
Major Depression (MDD)	0.2	0.2	0.7	0.0	0.5	0.8	0.0
Reaction Time	0.4	0.8	1.4	0.8	-0.4	1.1	1.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	0.6	-0.3	0.1	-1.0
Breast Cancer	0.1	0.2	0.4	0.6	-0.5	0.1	-0.2
Ovarian Cancer	0.5	0.6	1.8	-0.5	1.3	0.6	-0.2
Prostate Cancer	2.0	2.8	4.1	-1.8	-1.2	1.5	-2.0
Age at First Birth	0.3	0.4	1.2	-0.1	0.2	1.1	-0.6
Bipolar Disorder (2011)	0.5	0.5	2.0	0.0	1.4	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.0	2.6	-0.7	-0.1	-1.1	-1.6
Coronary Artery Disease (CAD)	1.1	1.3	2.9	1.7	-0.4	-0.3	1.5
Crohns Disease (2012)	0.6	1.0	1.6	-1.1	0.9	-1.3	0.6
Mean Putamen Volume	0.3	0.3	0.6	0.6	-0.8	-0.5	-0.3
Fasting Glucose	0.1	0.1	0.1	0.2	0.3	0.3	0.1
HbA1C	0.8	0.9	2.5	-1.0	0.1	-0.0	-1.6
HDL Cholesterol	0.3	0.5	1.2	-0.8	-1.1	-0.2	0.5
LDL Cholesterol	0.2	0.4	0.8	0.9	-0.6	0.1	0.5
Lupus	0.2	0.3	0.8	-0.9	-0.3	-0.1	-0.6
Neuroticism (2016)	0.4	0.6	1.6	-0.8	0.5	1.3	0.1
Primary Biliary Cirrhosis	1.1	1.6	5.1	0.8	-0.1	0.8	2.2
Rheumatoid Arthritis	2.7	3.7	10.9	3.3	1.0	-0.8	1.5
Schizophrenia (2014)	0.6	1.4	5.1	2.3	-0.1	0.4	0.5
Triglycerides	0.5	0.8	1.7	0.5	1.3	1.0	0.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.7	-1.1	-0.0	-1.9	-0.1
Ulcerative Colitis	0.9	1.3	2.7	0.0	-0.3	1.5	1.6
Blood Eosinophil Count	0.0	0.3	0.5	0.4	-0.5	-0.6	0.7
Blood Platelet Count	0.1	1.1	3.8	-0.3	0.5	-1.9	0.4
Blood Red Count	0.1	1.1	3.8	-0.3	-1.9	-0.6	0.0
Blood White Count	0.1	0.4	0.7	-0.8	-0.6	-0.1	0.8
Heel T-Score	0.1	0.7	1.8	0.9	-1.3	-0.3	-0.1
BMI	0.4	2.6	9.1	-1.1	-3.0	-0.1	-0.1
Height	0.1	2.1	4.5	1.1	1.5	2.1	0.8
Waist Hip Ratio (WHR)	0.3	1.2	2.4	1.3	-1.5	-0.5	-0.7
Systolic Blood Pressure	0.3	1.7	3.0	1.7	0.1	-1.6	1.0
Smoking Status	0.1	0.4	1.0	1.0	0.0	0.4	0.4
Allergy or Eczema	0.3	0.9	2.9	0.4	-0.1	0.7	1.7
Cardiovascular Disease	0.2	0.6	1.6	0.1	-1.3	0.8	-0.4
Hypothyroidism (self reported)	0.7	1.6	2.2	-1.1	-1.4	1.0	-1.5
Respiratory disease	0.3	0.7	2.2	0.6	0.2	-0.4	1.5
Type 2 Diabetes (T2D) (2018)	0.7	1.2	4.0	0.6	-0.6	-2.0	-0.4
Lung FEV1/FVC ratio	0.2	1.2	3.1	1.8	-0.4	0.7	1.1
Lung FVC	1.8	9.2	18.1	-4.3	-1.6	0.8	-3.9
Neuroticism	0.5	1.2	3.6	0.0	1.0	1.9	0.5
Chronotype (morning person)	0.5	1.2	3.1	0.2	-1.8	-1.0	-0.8
Hair Pigment	0.0	0.5	1.1	0.6	0.7	-0.3	-1.1
Tanning	0.1	0.8	3.3	-0.0	0.1	1.8	0.2
Hand grip strength (left)	0.2	0.5	1.5	-0.4	0.6	-0.1	1.2
Number of treatments/medications taken	0.5	0.9	2.6	-0.7	-0.6	0.0	-1.6
Average weekly spirits intake	0.5	0.6	1.5	-0.8	-0.5	-1.2	-0.4
Sensitivity / hurt feelings	0.9	1.6	5.5	-0.1	0.1	2.4	0.9
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.5	0.4	1.6	1.2	-0.4
Hearing difficulty/problems: Yes	1.1	1.6	5.6	2.4	-0.1	0.9	-0.0
Relative age of first facial hair	1.3	2.6	8.3	0.0	-1.3	0.7	-2.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.3	0.2	-0.1	-0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	1.0	0.6	-0.6	0.2
Ever had hysterectomy (womb removed)	2.9	3.3	5.3	2.1	-1.4	-1.2	2.3
Systolic blood pressure, automated reading	0.4	1.2	4.6	-0.4	-0.1	-2.1	0.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	0.2	-1.3	-0.4	-1.5
Angina	0.5	0.6	2.0	-0.2	-0.5	-0.2	1.4
Medication for hormone replacement therapy	1.0	1.1	3.5	0.8	0.6	-0.3	-1.9
Vitamin and mineral supplements	3.1	4.3	9.0	-2.1	-1.9	0.1	-3.0
Supplements: Zinc	1.3	1.4	2.5	1.4	1.6	0.2	1.1
Medication: Co-codamol	0.2	0.2	0.6	0.2	-0.5	-0.0	0.8
Medication: Metformin	0.6	0.8	1.4	-0.6	-1.2	-1.2	-0.2
Diabetes (father)	0.8	1.0	2.9	-1.7	1.0	-0.5	-0.1
Diabetes (mother)	0.2	0.2	0.3	-0.6	-0.4	-0.2	0.4
Severe depression (siblings)	1.0	1.1	1.7	1.3	0.1	1.3	-1.1
Pack years adult smoking proportion	0.9	1.4	2.3	1.5	-1.1	-1.4	-0.3
Impedance of leg (right)	0.3	1.4	2.7	-0.4	-1.6	-1.4	-1.0
Leg fat-free mass (left)	0.2	1.0	2.9	-0.9	-0.5	1.7	-0.2
Trunk fat percentage	1.5	5.8	17.3	-1.8	-4.2	-0.3	-1.7
Hand grip strength (right)	0.1	0.3	0.7	-0.5	0.3	0.9	0.5
Townsend deprivation index at recruitment	0.2	0.2	0.8	0.9	-0.3	-0.1	-0.0
Current tobacco smoking	0.2	0.3	0.8	-0.1	-0.4	-0.3	-0.9
Average weekly fortified wine intake	0.8	1.0	2.8	1.7	1.0	-0.2	-0.4
Maternal smoking around birth	0.1	0.2	0.7	-0.9	-0.0	0.4	-0.0
Fed-up feelings	1.0	1.9	5.6	-1.0	1.0	2.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.8	-0.3	1.3	1.9	-1.2
Relative age voice broke	1.6	2.4	8.5	0.5	-0.4	0.8	-2.9
Taking other prescription medications	1.2	1.8	2.3	-1.5	-1.3	-1.1	-1.5
Age when periods started (menarche)	0.2	0.6	1.7	-0.1	0.6	0.4	-1.3
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.9	1.5	-0.7	0.5	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.6	0.9	-0.7	1.3	-0.3
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.6	-0.0	-0.4	0.3	1.9
Qualifications: CSEs or equivalent	1.1	1.5	3.1	0.2	1.6	-0.4	1.8
Serious illness, injury or assault to yourself	1.4	1.8	4.3	0.7	1.4	0.2	2.1
High blood pressure	0.2	0.5	0.9	-0.3	-0.7	0.8	-1.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.2	-0.0	-0.1	0.2	1.8
Multivitamins +/- minerals	1.9	2.4	6.0	1.3	1.4	-0.2	2.5
Stomach or abdominal pain in last month	0.5	0.6	2.4	0.2	0.2	1.5	0.3
Supplements: Glucosamine	0.2	0.2	0.8	-0.3	0.2	-0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.1	-0.8	0.4	1.0	0.5
Medication: Atenolol	0.6	0.8	1.7	1.3	-0.3	-0.7	0.9
Medication: Levothyroxine sodium	0.5	0.9	2.1	-0.4	-0.2	-1.2	-1.4
Sitting height	0.2	1.5	3.3	0.9	1.3	1.8	0.4
Chronic bronchitis/emphysema (father)	1.8	2.1	6.9	-2.6	-1.0	0.5	-0.4
High blood pressure (mother)	0.1	0.1	0.3	0.4	0.1	-0.2	0.6
Body mass index (BMI)	1.0	4.1	11.2	-1.8	-3.4	-0.3	-1.3
Impedance of leg (left)	0.2	1.0	2.5	-0.1	-1.6	-0.9	-0.8
Leg predicted mass (left)	0.2	1.0	2.8	-1.0	-0.5	1.7	-0.3
Trunk fat mass	1.1	4.8	13.4	-1.8	-3.7	0.2	-1.7
Waist circumference	1.2	4.3	13.3	-1.4	-3.6	0.0	-1.4
Number of incorrect matches in round	0.2	0.3	0.6	0.4	0.3	0.7	0.8
Past tobacco smoking	0.3	0.5	1.6	-1.3	-0.6	0.4	-0.1
Alcohol usually taken with meals	0.7	1.1	1.9	-1.2	1.4	0.5	-0.9
Nervous feelings	0.2	0.4	0.7	-0.3	0.4	0.8	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.7	0.3	0.2	1.3	-0.2
Hearing difficulty/problems with background noise	0.9	1.5	3.4	1.6	0.1	1.9	-0.2
Hair/balding pattern: Pattern 2	0.5	0.6	1.3	1.1	-0.0	0.9	0.5
Had menopause	1.1	1.3	3.6	1.3	-0.1	-1.9	0.2
Had other major operations	0.7	0.9	2.2	0.2	0.3	-1.5	-1.0
Forced vital capacity (FVC)	0.7	2.9	4.6	-1.9	-1.0	2.1	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.8	-0.2	0.3	0.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.7	1.6	1.1	0.7	0.7
Qualifications: None of the above	0.6	1.4	3.6	1.9	0.0	1.0	1.0
Financial difficulties in last 2 years	1.9	2.6	4.3	-1.5	2.1	1.3	1.4
Mouth/teeth dental problems	1.3	2.0	2.9	1.6	1.5	-0.3	1.7
Heart attack	3.4	4.3	13.9	1.6	-0.7	-0.7	3.7
Allergy	0.4	0.8	3.3	0.1	-0.0	-0.1	-1.8
Pain all over the body in last month	1.4	1.5	3.0	-1.2	-1.7	0.9	-0.9
Diabetes (self-reported)	1.2	1.9	3.3	-0.1	-1.5	-1.8	-1.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	0.8	0.9	0.1	-0.6	0.8
Medication: Ramipril	1.9	2.5	7.9	-1.4	-2.8	0.2	0.1
Medication: Simvastatin	1.9	2.8	5.9	-1.0	-2.4	-0.9	-1.9
Fluid intelligence score	0.0	0.1	0.1	0.0	0.1	0.4	-0.4
Illnesses of siblings	0.9	1.3	3.3	0.5	1.8	0.7	0.9
Neuroticism score	1.1	2.3	7.7	-0.5	0.4	2.8	1.0
Weight	0.7	3.4	8.4	-1.7	-2.9	0.9	-1.3
Impedance of arm (right)	0.1	0.4	1.0	0.3	-0.6	-0.2	-1.0
Arm fat percentage (right)	1.3	5.3	13.2	-1.8	-3.6	-0.1	-2.2
Trunk fat-free mass	0.1	0.8	2.6	-0.8	0.3	1.6	-0.3
Hip circumference	0.8	3.4	9.5	-1.5	-3.1	0.7	-1.1
Time employed in main current job	0.6	0.7	1.1	-1.1	0.1	1.0	0.8
Alcohol intake versus 10 years previously	1.5	2.2	5.7	-1.3	-2.4	-0.2	1.2
Father’s age at death	0.7	0.9	1.9	-1.4	-0.4	-1.1	-0.8
Worrier / anxious feelings	0.7	1.3	2.8	0.7	0.8	1.2	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.6	-0.3	1.9	1.1	-0.5
Falls in the last year	0.2	0.2	0.5	0.7	-0.3	-0.1	-0.5
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	-0.4	0.8	-0.6	-0.6
Number of live births	1.1	1.6	4.5	-0.9	-0.5	0.9	-2.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.7	-1.2	-0.8	1.9	-0.9
Pulse rate	1.4	2.3	6.3	-1.4	-2.5	0.1	-1.0
Happiness	0.1	0.2	0.3	-0.5	0.6	0.1	-0.3
Noisy workplace	2.8	3.5	9.0	-1.3	-3.0	1.7	0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.8	-1.4	-0.8	-0.3	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.9	0.5	0.3	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	0.9	-0.7	-0.8	-1.0	-0.8
Asthma	0.2	0.4	1.2	0.7	-0.0	-1.1	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	0.3	-0.8	1.0	-0.1
Medication: Cholesterol lowering	0.2	0.4	0.9	0.7	-0.2	-1.0	0.2
Depression (self-reported)	0.3	0.4	0.8	0.1	0.8	0.9	0.3
Medication: Lansoprazole	0.6	0.7	1.9	0.1	1.4	-0.2	0.8
Prospective memory result	0.9	1.1	3.0	0.2	-0.7	0.9	-1.7
Lung cancer (father)	0.5	0.5	1.5	-0.3	-0.7	0.4	1.2
Illnesses of mother	0.4	0.5	1.2	-0.1	0.2	-0.9	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	3.2	-1.8	-0.4	1.3	-1.8
Pulse wave Arterial Stiffness index	1.4	1.6	2.8	-1.0	-1.3	1.0	-1.7
Impedance of arm (left)	0.1	0.4	0.9	0.7	0.0	-0.3	-0.9
Arm fat mass (right)	0.9	3.7	9.7	-1.4	-3.1	0.0	-1.8
Trunk predicted mass	0.2	0.9	2.8	-0.8	0.3	1.7	-0.4
Standing height	0.2	1.7	5.6	0.2	0.9	2.4	-0.5
Length of working week for main job	0.0	0.1	0.1	-0.1	-0.3	-0.3	-0.0
Exposure to tobacco smoke at home	0.5	0.6	1.1	1.1	-0.8	0.8	-0.1
Breastfed as a baby	0.5	0.6	2.0	-0.1	-0.6	0.3	1.4
Tense / ‘highly strung’	0.3	0.5	0.5	-0.7	-0.7	0.7	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.5	0.3	1.0	-0.6
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	-0.4	0.9	0.2	0.5
Birth weight of first child	0.1	0.1	0.2	0.3	0.1	-0.2	-0.5
Peak expiratory flow (PEF)	0.5	1.1	1.6	-1.2	-1.2	1.3	-0.1
Pulse wave reflection index	0.7	0.9	1.8	-1.1	0.2	0.6	-1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.9	-0.4	-0.2	1.4	0.1
Loud music exposure frequency	0.9	1.0	1.6	0.2	1.2	0.8	1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.8	-0.4	0.4	-0.5	1.7
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	3.9	-2.0	-1.9	1.0	-1.6
Blood clot in the leg (DVT)	0.2	0.3	0.6	0.4	0.3	0.8	0.7
Medication: Paracetamol	0.8	1.3	4.5	0.3	0.2	2.1	0.8
Headache pain in last month	1.7	2.9	6.1	1.7	1.7	-0.1	2.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	-0.3	0.9	0.4	1.1
Glaucoma (self-reported)	0.4	0.4	1.6	-0.0	0.2	-1.3	0.1
Gout (self-reported)	0.9	1.3	5.0	-0.3	-0.3	2.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.5	-1.5	-1.3	0.6	-1.6
Medication: Amlodipine	0.4	0.5	1.8	0.1	1.4	0.1	0.3
Medication: Ventolin 100micrograms inhaler	1.9	2.5	5.3	-1.1	1.5	-2.3	-1.1
Birth weight	0.1	0.3	0.7	-0.3	0.8	0.5	0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	0.1	-0.2	0.3	-0.1
High blood pressure (siblings)	1.0	1.5	1.8	-1.3	-1.3	-1.2	-1.0
Forced vital capacity (FVC), Best measure	0.8	3.0	5.9	-2.2	-0.3	1.1	-2.4
Body fat percentage	1.9	7.5	22.5	-2.1	-4.7	-0.3	-1.8
Leg fat percentage (right)	2.9	10.4	28.6	-2.8	-5.4	-0.8	-2.1
Arm fat-free mass (right)	0.1	0.7	1.6	-1.0	-0.2	1.3	-0.3
Exposure to tobacco smoke outside home	1.0	1.3	2.8	1.2	1.7	-0.9	0.4
Comparative body size at age 10	0.5	1.5	3.3	-0.5	-0.3	1.6	1.8
Number of full brothers	0.5	0.6	1.8	0.4	1.3	0.4	-0.4
Worry too long after embarrassment	1.0	1.6	5.1	0.9	0.7	2.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	6.6	2.6	1.4	1.7	-0.9
Wheeze or whistling in the chest in last year	0.4	0.7	0.8	0.8	-0.9	-0.7	-0.9
Number of children fathered	0.2	0.2	0.6	-0.3	-0.3	-0.3	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.3	-1.3	0.7	-1.5	0.5
Age at first live birth	0.2	0.4	0.7	-0.4	0.8	0.8	-0.0
Pulse wave peak to peak time	1.4	1.6	2.9	1.1	1.3	-0.9	1.7
Health satisfaction	1.2	1.6	3.9	0.7	-0.1	2.0	1.4
Shortness of breath walking on level ground	1.2	1.5	2.3	-0.9	-1.5	-0.7	-1.5
Qualifications: College or University degree	0.2	0.7	1.6	-0.2	0.4	-1.3	-1.0
Eye problems/disorders: None of the above	2.2	2.5	5.0	0.7	1.1	2.2	1.9
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.6	-0.5	-1.7	1.9	0.1
Emphysema/chronic bronchitis	1.0	1.2	2.7	0.0	-1.3	-0.4	1.6
Medication for pain relief, constipation, heartburn	0.6	1.0	3.3	-0.2	0.1	-1.8	-0.7
Neck or shoulder pain in last month	1.4	2.0	5.6	1.4	2.4	-0.2	0.6
Medication: Blood pressure	0.1	0.1	0.3	-0.3	-0.1	-0.1	-0.5
Angina (self-reported)	0.4	0.6	1.7	-0.2	-0.7	-0.0	1.3
Migraine (self-reported)	1.2	1.5	4.5	-0.6	-2.1	-0.8	0.8
Medication: Ibuprofen	0.5	0.6	1.6	0.0	-0.9	1.3	-0.4
Medication: Allopurinol	0.3	0.4	0.6	-0.8	0.8	-0.3	0.7
Medication: Omeprazole	0.1	0.1	0.2	-0.4	0.4	-0.5	0.0
Medication: Seretide 50 evohaler	0.8	0.9	2.2	0.4	0.1	1.1	-1.5
Mean time to correctly identify matches	0.6	1.1	2.0	0.7	-1.4	1.0	0.9
Heart disease (mother)	1.3	1.6	3.8	1.2	-1.0	-0.3	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.5	2.1	0.5	-0.4	0.9
Whole body fat mass	1.3	5.3	15.9	-1.7	-4.0	-0.0	-1.5
Leg fat mass (right)	1.8	6.8	17.9	-2.4	-4.2	-0.4	-1.8
Arm predicted mass (right)	0.1	0.6	1.6	-0.9	0.0	1.2	0.0
Pulse rate, automated reading	1.3	4.2	9.9	-3.1	-1.8	0.2	-1.9
Alcohol intake frequency.	0.6	1.3	4.0	0.7	-0.2	-0.8	2.0
Comparative height size at age 10	0.2	1.0	2.5	1.6	0.6	-0.9	0.7
Number of full sisters	1.0	1.2	4.4	-0.4	-0.3	0.6	-2.1
Suffer from ‘nerves’	0.4	0.6	1.0	-0.5	0.9	0.6	1.0
Overall health rating	0.1	0.3	0.5	0.3	-0.5	0.6	-0.7
Chest pain or discomfort	0.3	0.5	1.1	-0.5	0.1	0.8	1.0
Had major operations	0.7	0.8	2.7	-0.6	1.6	-0.6	-0.2
Age at last live birth	0.4	0.6	1.2	-0.6	1.1	-0.9	-0.3
Family relationship satisfaction	0.5	0.7	1.1	1.0	1.0	-0.8	0.1
Leg pain on walking	1.1	1.4	3.0	0.6	0.2	1.5	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.1	-1.4	-0.2	0.7	0.0
Commuting to job workplace: Car/motor vehicle	2.2	2.6	3.9	-0.9	-1.8	-2.0	-1.5
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	5.0	0.5	-2.0	-0.2	-2.2
Medication: Aspirin	0.3	0.4	1.1	-0.1	-1.1	-0.3	-0.6
Supplements: Vitamin C	0.5	0.6	1.6	0.6	1.3	-0.1	0.5
Knee pain experienced in last month	0.4	0.6	1.5	-0.3	-1.2	-0.8	-0.3
Hypertension (Self-reported)	0.2	0.4	1.0	-0.2	-0.8	0.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.0	-0.4	0.6	-1.4	0.4
Illnesses of father: Heart disease	0.5	0.7	2.4	1.5	-0.1	-0.4	0.2
Illnesses of siblings: Diabetes	0.5	0.6	2.1	0.0	-0.5	1.4	0.3
Smoking status: Previous	0.6	0.9	2.7	1.6	0.2	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	6.3	0.9	-0.4	2.5	-0.9
Whole body fat-free mass	0.2	1.0	3.0	-0.9	-0.1	1.7	-0.2
Leg fat-free mass (right)	0.2	1.0	3.6	-0.7	0.1	1.9	0.0
Arm fat percentage (left)	1.3	5.1	13.0	-1.8	-3.6	-0.1	-2.1
Average weekly red wine intake	0.3	0.4	0.8	-0.7	0.1	0.6	-0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	1.0	0.5	-0.3	0.9
Mood swings	0.4	0.8	2.2	0.2	0.9	1.5	-0.2
Loneliness, isolation	1.0	1.4	3.3	-1.5	0.6	1.8	0.1
Long-standing illness, disability or infirmity	0.2	0.2	0.5	0.4	-0.7	0.4	-0.4
Ever had bowel cancer screening	0.2	0.2	0.3	-0.6	0.5	0.4	0.5
Diabetes diagnosed by doctor	0.8	1.4	3.0	0.2	-1.7	-1.0	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.0	-1.4	-0.4	0.6	-0.9
Friendships satisfaction	0.3	0.4	0.9	-0.2	0.3	0.9	-0.7
Qualifications: nursing, teaching	0.4	0.7	1.6	-1.0	0.5	0.1	-1.3
Commuting to job workplace: Walk	1.1	1.2	2.2	0.4	1.0	1.5	1.1
Eye problems/disorders: Cataract	1.9	2.2	7.7	-0.2	0.1	-1.0	-2.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	-0.8	0.6	-0.3	-1.2
Medication for cholesterol	1.4	2.2	5.8	0.1	1.6	-0.6	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.8	-0.1	0.8	0.2	1.3
Back pain experienced in last month	2.7	3.9	10.7	3.3	1.2	-0.2	1.8
Mineral and other dietary supplements	2.1	2.9	6.8	-1.2	-0.6	2.6	-1.7
Breast cancer (self-reported)	2.1	2.5	7.7	0.7	2.8	-0.5	1.3
Asthma (self-reported)	0.2	0.4	1.4	0.5	0.0	-1.2	-0.2
Osteoporosis (self-reported)	1.5	1.9	6.2	0.8	-0.3	-2.5	-0.7
Osteoarthritis (self-reported)	0.7	1.0	1.2	1.1	0.4	-1.1	-1.1
Medication: Aspirin	0.2	0.2	0.5	0.1	-0.3	-0.5	-0.7
Medication: Gliclazide	0.3	0.3	0.4	-0.5	-0.6	-0.6	-0.5
Illnesses of father: None of the above (group 1)	0.9	1.1	1.9	1.2	1.0	0.4	1.4
Smoking status: Current	0.2	0.4	1.2	-0.2	-0.2	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	7.8	-2.8	-1.4	0.1	-0.6
Whole body water mass	0.2	0.9	2.8	-0.9	-0.0	1.7	-0.2
Leg predicted mass (right)	0.2	1.0	3.4	-0.7	0.0	1.8	0.1
Arm fat mass (left)	0.8	3.3	8.9	-1.3	-3.0	-0.2	-1.6
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	-0.9	-0.3	0.2	-1.1
Average weekly champagne plus white wine intake	0.4	0.5	1.5	-0.6	0.4	-1.2	-0.0
Miserableness	0.6	1.1	3.4	-0.7	0.7	1.9	-0.3
Guilty feelings	0.8	1.2	2.2	0.7	0.6	1.3	1.5
Wears glasses or contact lenses	1.2	1.4	4.0	-1.0	-0.5	-0.5	-2.0
Ever taken oral contraceptive pill	0.9	1.0	2.5	-1.2	-1.6	0.1	-0.4
Hearing aid user	0.9	1.1	2.2	-1.0	-1.5	0.1	-1.1
Mother’s age at death	0.4	0.5	1.0	0.5	-1.0	-0.9	-0.4
Financial situation satisfaction	0.4	0.5	0.9	-0.9	0.1	0.6	-0.8
Tinnitus: Yes, now most or all of the time	1.9	2.2	7.8	2.8	-0.5	0.9	-0.0
Commuting to job workplace: Public transport	0.6	0.7	1.0	0.8	0.7	1.0	0.9
Eye problems/disorders: Glaucoma	1.1	1.3	4.5	0.1	-0.4	-2.1	-0.7
Medication: Blood pressure	0.8	1.6	3.4	-0.1	-1.8	1.3	-1.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	0.2	-0.8	0.1	-0.6
Supplements: Fish oil (including cod liver oil)	1.6	2.0	3.1	1.8	0.9	-1.3	1.6
High cholesterol (Self-reported)	0.5	0.8	2.3	-0.2	-1.5	-1.0	-0.3
Medication: Bendroflumethiazide	0.6	0.9	1.5	0.2	1.1	0.9	-1.2
Medication: Paracetamol	0.8	1.2	4.2	-0.0	-0.0	2.0	0.8
Medication: Lisinopril	1.4	1.8	5.9	0.1	-0.9	2.4	-0.7
Medication: Atorvastatin	0.9	1.1	2.2	1.4	0.3	-0.2	1.5
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.0	0.4	-0.5	-0.3
Alcohol drinker status: Never	1.2	1.5	2.8	-0.1	-0.8	-1.7	1.6
Ever smoked	0.3	0.5	1.1	0.3	0.4	-0.9	-1.1
Basal metabolic rate	0.2	1.0	2.4	-1.0	-0.7	1.5	-0.4
Leg fat percentage (left)	2.7	9.7	27.7	-2.7	-5.3	-0.6	-1.9
Arm fat-free mass (left)	0.2	1.0	1.7	-1.3	-0.9	1.3	-0.1
Number of operations (self-reported)	1.1	1.7	5.2	-0.7	2.3	-0.5	-0.9
Average weekly beer plus cider intake	1.0	1.4	3.1	-1.8	1.2	0.4	1.0
Irritability	0.3	0.5	1.1	-0.5	-1.0	0.8	-0.1
Risk taking	0.4	0.5	0.8	0.1	0.8	-0.8	0.9
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	0.7	0.7	0.0	-0.4
Fractured/broken bones in last 5 years	0.7	0.9	1.4	0.8	1.2	0.9	1.0
Age started oral contraceptive pill	1.2	1.5	5.4	-0.2	-2.3	-0.6	-0.2
Diastolic blood pressure, automated reading	0.7	2.1	6.7	-2.6	-0.5	-0.2	-1.3
Ever depressed for a whole week	0.7	0.9	2.2	1.5	1.0	0.5	-0.2
Unable to work because of sickness or disability	0.3	0.4	0.8	0.9	-0.2	0.1	-0.9
Commuting to job workplace: Cycle	0.1	0.1	0.5	0.3	0.1	-0.7	-0.1
Myopia	1.7	2.4	4.0	-1.8	2.0	-0.4	-1.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.4	0.2	0.4	-1.2	0.5
Cholesterol lowering medication	1.7	2.5	5.0	-1.4	-2.2	-0.4	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.3	0.3	-0.6	0.9
Pain experienced in last month	0.6	1.0	2.0	-0.9	-1.4	-0.2	-1.0
Supplements: Calcium	0.7	0.8	1.7	0.3	-0.1	-1.1	1.3
Basal cell carcinoma (self-reported)	0.9	1.0	3.4	-1.9	-0.3	0.5	0.5
Heart attack/myocardial infarction (self-reported)	2.9	3.7	11.7	1.5	-0.7	-0.8	3.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	0.2	0.1	1.1	0.4
Heart disease (siblings)	0.4	0.5	0.8	0.9	-0.6	-0.8	0.5
Alcohol drinker status: Previous	2.2	2.5	6.9	1.0	1.4	0.4	2.6
Pack years of smoking	0.6	1.0	1.4	1.2	-1.2	-0.9	-0.4
Impedance of whole body	0.1	0.4	0.9	0.3	-1.0	-0.3	-0.8
Leg fat mass (left)	1.8	7.0	18.4	-2.4	-4.3	-0.1	-1.9
Arm predicted mass (left)	0.2	1.0	2.0	-0.9	-1.0	1.4	-0.2