TWAS hub - USP15

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1760	0.0620	9.6e-04	0.027	NA	0.032	NA	0.028	2.7e-03	NA	1.2e-03	NA	2.1e-03
2	GTEx	Artery Aorta	0.3610	0.0620	1.6e-12	0.382	NA	0.386	NA	0.388	2.8e-22	NA	1.6e-22	NA	1.2e-22
3	GTEx	Brain Caudate basal ganglia	0.3360	0.1030	3.6e-03	0.034	NA	-0.002	NA	0.051	3.7e-02	NA	3.6e-01	NA	1.4e-02
4	GTEx	Whole Blood	0.0950	0.0400	7.1e-03	0.054	NA	0.012	NA	0.026	9.6e-06	NA	2.5e-02	NA	1.8e-03
5	METSIM	Adipose	0.0536	0.0196	6.3e-04	0.034	0.019	0.002	0.017	0.022	7.4e-06	6.3e-04	1.7e-01	1.1e-03	2.6e-04
6	NTR	Blood	0.0317	0.0128	9.2e-04	0.014	0.011	0.012	0.013	0.010	2.1e-05	9.9e-05	6.1e-05	3.3e-05	3.3e-04
7	YFS	Blood	0.0675	0.0164	8.3e-10	0.028	0.034	0.037	0.030	0.023	9.8e-10	2.9e-11	3.8e-12	4.7e-10	3.0e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2011)	2.9	2.8	5.9	-1.9	0.6	-1.5	-2.4	2.2	0.2	-1.5
Number of full sisters	2.5	3.0	5.8	-2.4	0.0	2.0	-1.9	-1.1	-2.3	-0.9
Schizophrenia vs Biploar Disorder	2.4	3.2	13.3	-0.3	0.0	-0.4	-1.6	-3.6	-1.5	-2.0
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	6.4	-1.7	-2.1	0.5	-1.3	-2.5	-1.2	-0.6
Number of children fathered	2.2	2.5	5.0	-1.6	1.3	-1.9	-1.1	-1.4	-2.2	-0.9
Myopia	2.1	3.0	9.4	1.5	-3.1	0.0	-0.1	-1.3	1.9	2.0
Blood Eosinophil Count	1.9	14.8	33.1	4.0	-5.8	0.4	4.8	0.3	2.1	5.2
Average weekly fortified wine intake	1.9	2.3	6.9	1.7	0.9	1.3	0.7	2.6	1.7	-0.0
Ever had bowel cancer screening	1.9	2.3	5.3	0.5	-2.3	2.1	0.6	-0.2	0.4	2.3
Alcohol intake versus 10 years previously	1.8	2.6	7.1	-2.5	-1.5	0.2	-1.5	-0.7	-2.7	0.0
Commuting to job workplace: Walk	1.8	1.9	4.9	0.8	-2.2	1.3	-1.7	-1.5	0.9	-0.6
Bipolar Disorder (2018)	1.6	2.5	6.5	-2.4	1.0	-0.1	-2.5	1.0	-1.0	-1.6
Schizophrenia (2014)	1.6	3.4	11.0	-2.0	1.1	-1.0	-3.3	-1.1	-0.3	-2.4
Qualifications: A levels/AS levels or equivalent	1.6	3.4	19.9	-0.3	-0.1	0.9	-0.8	-4.5	1.1	-1.1
Pulse rate	1.5	2.6	10.6	-1.4	3.3	-1.4	0.7	1.0	-0.2	-1.5
Lung cancer (father)	1.5	1.8	4.9	-1.8	0.6	-0.7	-1.3	-0.6	-2.2	-1.2
Supplements: Calcium	1.5	1.6	4.6	1.8	-0.7	-0.6	0.7	0.4	2.1	1.3
Ovarian Cancer	1.4	1.8	4.8	0.7	-1.5	-0.4	1.1	1.4	1.3	2.2
Maternal smoking around birth	1.4	2.1	7.9	-0.5	0.7	2.8	-0.6	0.3	-1.6	-1.7
Qualifications: None of the above	1.4	3.0	6.6	-0.0	-1.1	-1.8	1.9	1.6	-1.8	2.6
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	6.7	-1.0	0.2	1.8	-0.5	-2.6	1.6	-1.2
Illnesses of father: Heart disease	1.4	2.0	4.8	-1.1	1.8	-2.2	-1.0	0.1	-0.2	-1.8
Mood swings	1.4	2.5	9.2	0.9	-3.0	0.6	1.3	-0.9	0.4	2.2
Miserableness	1.4	2.4	8.4	1.2	-2.9	1.4	0.4	-0.8	1.8	0.8
Alzheimer’s Disease (in father)	1.3	1.4	3.0	1.7	-1.3	-0.3	1.3	-0.3	1.6	1.0
Supplements: Glucosamine	1.3	1.7	4.8	1.2	0.4	-1.4	0.9	0.8	2.2	1.4
Pain all over the body in last month	1.3	1.4	3.5	1.9	-0.4	-1.3	1.7	-0.7	1.0	0.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.8	-1.0	-1.3	1.1	-2.4	-0.1	-0.2	-1.4
Happiness	1.3	1.6	3.1	-0.7	0.3	-1.2	-1.5	-1.8	-0.8	-1.7
Breastfed as a baby	1.3	1.6	4.9	-0.7	1.4	2.2	-1.3	1.1	1.0	-0.3
Birth weight of first child	1.3	2.3	6.7	2.6	-0.7	-1.8	1.4	0.4	1.8	0.3
Age at first live birth	1.3	2.4	6.6	2.5	0.9	-1.1	1.0	0.2	2.6	-0.7
Eye problems/disorders: None of the above	1.3	1.5	3.7	-0.0	1.9	-0.2	-1.5	-1.0	-0.9	-1.7
Heart disease (mother)	1.3	1.6	3.7	1.4	-1.0	-0.8	1.1	-1.6	-1.9	0.3
Average weekly red wine intake	1.3	2.0	8.3	1.0	-0.7	-0.7	0.8	-1.6	2.9	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	6.1	1.4	-0.0	2.5	-0.0	0.8	0.9	-0.4
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.9	1.4	-1.1	-0.2	1.4	2.2	0.3	0.7
Bipolar Disorder or Schizophrenia	1.2	2.9	10.3	-1.9	1.3	-0.2	-3.2	0.6	-0.1	-2.0
Major Depression (MDD)	1.2	1.5	5.8	0.0	-0.8	-1.1	-2.4	-0.6	-0.7	-1.3
Blood Platelet Count	1.2	14.1	50.7	-1.5	-7.1	-2.1	-0.4	-3.7	-3.4	4.0
BMI	1.2	6.7	15.0	-3.3	2.0	0.5	-3.5	-1.7	-1.3	-3.9
Fed-up feelings	1.2	2.1	8.5	0.7	-2.9	1.3	1.2	-1.0	-0.4	1.3
Length of working week for main job	1.2	1.3	3.8	-0.6	0.5	-0.6	-0.2	-2.0	-1.3	-1.5
Blood clot in the leg (DVT)	1.2	1.5	5.5	0.2	0.3	0.4	0.9	1.3	1.5	2.4
High blood pressure (siblings)	1.2	1.8	7.2	1.1	-1.0	0.2	2.7	0.1	-0.3	1.6
Number of full brothers	1.2	1.5	4.7	-1.4	0.2	-1.8	-0.5	0.0	-2.2	-0.0
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.5	0.7	-1.0	-1.8	-0.1	-1.9	-1.4	-0.2
Pulse rate, automated reading	1.2	3.8	13.9	-1.4	3.7	-2.2	0.2	-0.4	0.6	-2.3
Arm fat percentage (left)	1.2	4.7	11.3	-2.6	1.4	-0.4	-3.4	-1.4	-1.9	-2.7
Qualifications: nursing, teaching	1.2	1.9	7.3	-0.8	0.0	0.5	-1.0	-2.7	1.2	-1.6
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.8	-1.0	-0.1	-0.7	-1.9	-0.6	-0.5	-1.9
Age at First Birth	1.1	1.5	4.2	1.3	-0.9	-1.0	1.2	1.2	2.0	-0.5
Triglycerides	1.1	1.8	5.0	1.2	-2.2	0.7	1.2	-0.4	0.6	2.0
Chronotype (morning person)	1.1	2.4	9.7	0.6	0.3	0.3	1.9	-1.3	-1.3	3.1
Sensitivity / hurt feelings	1.1	1.9	6.3	-0.4	-0.5	2.5	-1.9	-1.3	-0.4	-1.1
Diabetes (father)	1.1	1.4	3.1	1.0	-1.8	-0.1	0.2	0.7	1.6	1.5
Pack years adult smoking proportion	1.1	1.6	5.6	1.6	-2.4	-0.8	0.3	0.7	1.1	0.9
Hand grip strength (right)	1.1	3.0	7.8	-1.2	1.5	0.6	-1.5	-1.9	-1.9	-2.8
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	7.1	-1.1	0.4	-2.7	-1.8	-1.0	0.3	-2.3
Arm fat percentage (right)	1.1	4.3	9.3	-2.4	1.8	-0.8	-3.1	-1.0	-1.7	-2.8
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.6	1.5	-1.4	1.9	1.2	0.3	1.4	0.8
Medication: Amlodipine	1.1	1.5	3.5	1.9	-1.0	-0.2	1.6	0.9	0.7	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.6	-0.6	-1.0	-1.7	-0.8	-1.9	-0.6	0.5
Age at last live birth	1.1	1.6	4.2	1.5	1.2	0.1	1.1	1.4	2.0	-0.3
Commuting to job workplace: Car/motor vehicle	1.1	1.3	5.0	0.1	2.2	-1.1	0.8	-0.1	-1.4	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	6.2	0.6	-0.4	-0.6	1.0	-2.5	1.1	0.1
Hearing aid user	1.1	1.2	2.6	1.3	-0.8	-1.0	0.2	1.6	-1.3	0.7
Average weekly beer plus cider intake	1.1	1.6	5.8	-0.6	-0.4	-0.5	1.9	0.7	0.7	2.4
HbA1C	1.0	1.1	2.8	1.1	1.7	0.2	-0.5	1.4	1.3	-0.4
Supplements: Zinc	1.0	1.1	3.3	1.8	-1.8	-0.2	0.5	0.5	0.4	0.9
Townsend deprivation index at recruitment	1.0	1.4	4.4	1.2	-2.1	1.7	-0.8	0.4	0.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	5.7	0.3	-0.2	1.5	0.8	0.3	2.4	0.7
Hayfever, allergic rhinitis or eczema	1.0	2.2	8.2	-0.1	-2.2	2.9	-0.0	-1.4	-0.8	0.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.3	-1.4	-1.2	0.8	-0.8	-1.8	-0.5	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	7.7	-0.5	1.1	-2.8	-1.4	-0.1	-0.0	-2.3
Fluid intelligence score	1.0	2.2	4.0	0.9	0.9	0.1	-1.8	-2.0	1.5	-2.0
Neuroticism score	1.0	2.0	3.2	1.7	-1.7	1.8	0.5	-1.3	1.5	1.0
Hip circumference	1.0	4.3	10.0	-2.5	1.9	0.3	-2.9	-0.5	-1.3	-3.2
Arm fat mass (right)	1.0	4.0	8.3	-2.3	1.9	-0.3	-2.7	-0.5	-1.7	-2.9
Medication: Seretide 50 evohaler	1.0	1.1	4.8	-0.2	2.2	-1.0	-0.5	0.0	0.0	-1.3
Eye problems/disorders: Cataract	1.0	1.2	4.9	0.2	-1.5	2.2	0.1	-0.5	0.1	1.0
Medication for cholesterol	1.0	1.6	3.9	-0.8	0.8	0.5	-1.3	-1.9	0.2	-2.0
Back pain experienced in last month	1.0	1.5	7.0	-2.6	0.1	1.6	-0.2	-0.4	-0.8	-0.4
Financial situation satisfaction	1.0	1.3	4.6	-1.5	-0.7	-1.1	-0.7	-2.1	0.1	0.2
Irritability	1.0	1.7	6.3	0.3	-0.7	1.2	0.6	-2.5	1.7	0.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	4.2	-0.0	-0.7	-1.3	-1.4	-2.1	-0.7	-0.4
Neuroticism (Nagel 2018)	0.9	2.0	6.0	-0.1	-2.3	1.6	-0.3	-2.5	-0.7	0.2
Fasting Glucose	0.9	1.0	2.6	0.5	-0.7	-0.8	0.7	-1.5	-1.6	0.7
Waist Hip Ratio (WHR)	0.9	4.1	12.9	1.8	-2.5	0.9	1.4	0.0	-1.9	3.6
Allergy or Eczema	0.9	2.3	11.8	-0.4	-1.8	3.4	-0.6	-0.5	-0.4	0.2
Hypothyroidism (self reported)	0.9	2.0	6.9	1.1	-1.3	-0.8	0.8	2.6	-0.2	1.8
Hand grip strength (left)	0.9	2.2	6.2	-1.1	1.7	1.3	-1.5	-0.5	-0.9	-2.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.1	0.7	-0.1	-1.4	1.0	1.0	1.1	1.1
Angina	0.9	1.2	2.9	1.7	-1.2	-1.7	0.5	-0.9	0.1	0.6
Alcohol usually taken with meals	0.9	1.4	7.0	-0.2	-1.5	-0.3	0.4	-2.6	0.2	0.8
Nervous feelings	0.9	1.6	7.0	0.8	-0.9	2.6	-0.6	-1.4	-0.4	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	2.9	0.7	-1.7	0.9	1.4	-0.6	1.7	0.3
Hair/balding pattern: Pattern 2	0.9	1.2	2.8	-1.7	1.1	0.6	-1.0	0.7	-1.1	-1.1
Allergy	0.9	2.1	6.4	-0.1	2.5	-2.2	-0.6	1.1	0.4	-1.2
Medication: Ramipril	0.9	1.2	5.1	-0.6	-0.8	-0.5	-1.1	0.1	-2.3	0.9
Medication: Simvastatin	0.9	1.4	5.3	0.4	-2.3	-0.6	-0.0	0.2	1.1	1.6
Illnesses of siblings	0.9	1.2	3.6	-1.1	1.0	0.1	-1.9	-0.2	0.9	-1.4
Falls in the last year	0.9	1.2	2.5	-1.6	-1.1	1.2	-0.7	-1.0	-1.3	0.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.1	-1.4	-0.0	1.7	-1.3	-0.7	-0.5	-0.3
Birth weight	0.9	1.9	3.6	1.5	1.6	-0.2	1.5	1.9	1.3	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.3	-0.6	0.2	0.1	-1.8	-1.5	-0.8	-0.9
Alcohol intake frequency.	0.9	2.1	4.4	-1.1	0.0	1.9	-2.1	1.0	-1.9	-0.7
Had major operations	0.9	1.0	3.6	1.1	-1.4	-1.9	-0.2	-0.4	0.2	0.3
Loneliness, isolation	0.9	1.2	3.1	1.5	0.0	1.7	-0.5	1.8	0.2	-0.5
Osteoarthritis (self-reported)	0.9	1.2	3.9	-0.2	2.0	-0.2	-0.4	1.7	0.6	-1.0
Guilty feelings	0.9	1.3	2.8	-0.3	-1.1	1.4	-0.8	-1.7	1.6	-0.5
Ever taken oral contraceptive pill	0.9	1.0	4.2	0.3	-0.5	0.6	-0.7	-2.1	-1.2	-0.2
Medication: Blood pressure	0.9	1.7	3.5	0.5	-1.2	-0.9	1.6	1.6	-1.1	1.9
Medication: Lisinopril	0.9	1.2	6.3	-0.7	0.5	-0.6	-0.6	-0.3	-2.5	-0.8
Alcohol drinker status: Never	0.9	1.1	2.5	0.5	1.6	-0.3	-1.4	1.4	-0.2	-1.0
Cholesterol lowering medication	0.9	1.3	3.4	1.0	-0.9	-0.8	1.0	1.3	0.4	1.9
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	4.8	0.1	0.1	0.7	0.8	0.8	1.1	2.2
Pack years of smoking	0.9	1.3	5.1	1.4	-2.3	-0.6	-0.0	0.7	0.7	0.9
Worry (Nagel 2018)	0.8	1.8	5.3	1.2	-1.4	1.5	0.6	-2.3	-0.9	0.4
Crohns Disease (2017)	0.8	1.7	4.3	1.0	-1.3	1.1	2.1	-0.1	0.9	1.6
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.2	-0.2	1.0	0.7	-2.5	-0.9	1.3	-1.9
Ulcerative Colitis	0.8	1.2	2.4	-1.0	-0.5	-1.5	-1.0	-1.5	-1.3	-0.2
Heel T-Score	0.8	6.0	14.2	-0.5	1.4	-3.5	-2.4	-2.7	0.1	-3.8
Average weekly spirits intake	0.8	1.0	2.6	1.1	-1.6	-0.0	-0.4	1.4	1.0	0.0
Ever had hysterectomy (womb removed)	0.8	0.9	3.7	0.3	-0.1	-1.0	1.1	1.9	0.6	0.6
Diabetes (mother)	0.8	1.0	2.3	1.5	0.9	-0.2	1.1	1.4	0.5	0.4
Severe depression (siblings)	0.8	0.9	3.4	-0.7	-1.8	-0.0	-0.2	-1.3	-0.5	0.4
Taking other prescription medications	0.8	1.3	5.8	0.6	-1.4	-0.8	0.3	-2.4	-0.3	0.2
Financial difficulties in last 2 years	0.8	1.1	2.6	1.1	-1.4	-1.3	-0.0	0.5	1.6	0.6
Time employed in main current job	0.8	0.9	2.1	-1.3	0.6	-1.4	0.4	-0.3	-1.4	-0.1
Number of live births	0.8	1.1	2.0	-0.7	-0.9	0.4	1.1	-1.1	-1.4	1.3
Asthma	0.8	1.5	5.9	0.6	-2.4	-0.5	0.7	-1.2	-0.4	1.4
Prospective memory result	0.8	1.0	2.4	0.7	0.2	-0.7	1.1	0.4	-1.5	1.5
Tense / ‘highly strung’	0.8	1.4	2.3	1.3	-1.4	1.5	1.1	-0.5	0.6	1.3
Headache pain in last month	0.8	1.4	3.6	0.9	-0.5	0.2	-0.7	-1.0	-1.9	-1.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.7	0.3	-1.9	-0.5	0.4	1.7	-0.9	1.6
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.3	0.2	-1.8	-1.2	0.1	-1.2	-0.8	0.2
Body fat percentage	0.8	3.0	7.2	-2.3	0.8	-0.2	-2.7	-1.2	-1.5	-2.0
Shortness of breath walking on level ground	0.8	0.9	3.4	-0.4	0.7	-1.2	0.0	-1.0	-1.9	0.3
Angina (self-reported)	0.8	1.1	2.9	1.3	-1.0	-1.7	-0.0	-1.4	-0.2	0.0
Supplements: Vitamin C	0.8	0.9	4.5	-0.4	0.8	-0.4	-2.1	0.5	0.2	-0.9
Handedness (chirality/laterality): Left-handed	0.8	0.9	4.0	0.8	0.7	-0.6	-0.5	-0.2	-2.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.5	-0.2	-0.3	-1.6	0.6	-1.3	0.9	0.9
Breast cancer (self-reported)	0.8	1.0	2.6	0.6	0.4	0.7	-0.9	1.6	-1.3	-1.1
Medication: Aspirin	0.8	1.0	3.5	0.5	-0.1	-0.2	-1.4	-0.9	-1.9	-0.9
Medication: Gliclazide	0.8	0.9	3.6	0.3	0.1	0.4	-1.5	1.9	0.6	-0.2
Arm fat mass (left)	0.8	3.3	6.9	-2.1	1.5	0.3	-2.6	-0.6	-1.8	-2.5
Commuting to job workplace: Public transport	0.8	0.9	2.5	0.4	-1.3	-0.7	0.9	0.2	1.6	0.6
Pain experienced in last month	0.8	1.4	4.2	1.3	0.2	-1.3	-0.9	0.9	2.1	0.4
Basal cell carcinoma (self-reported)	0.8	1.0	3.5	0.3	0.7	-0.7	-0.3	0.6	-1.2	-1.9
Intelligence (Savage-Jansen 2018)	0.7	2.1	7.6	1.2	-0.1	1.3	-1.2	-1.3	2.8	-0.7
Alzheimer’s Disease (in mother)	0.7	0.8	3.2	0.6	-1.1	0.8	-0.3	-0.3	1.8	0.5
Ulcerative Colitis (UC)	0.7	1.3	3.3	-1.8	-0.0	-1.2	-1.2	-0.9	-1.2	-0.9
Mean Putamen Volume	0.7	0.8	1.9	-0.3	1.4	-0.1	-0.7	1.1	0.4	-1.2
HDL Cholesterol	0.7	1.2	4.7	0.4	1.4	-2.2	0.1	-1.0	0.2	-0.5
Smoking Status	0.7	1.7	3.8	0.8	0.2	-2.0	0.2	-1.9	-1.8	-0.5
Cardiovascular Disease	0.7	2.2	6.0	0.2	-2.5	0.5	0.5	-1.6	-1.7	1.8
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.9	-0.2	0.8	-0.0	0.6	1.3	2.0	0.3
Trunk fat percentage	0.7	2.9	7.5	-1.8	0.4	-0.4	-2.7	-1.9	-1.7	-1.6
Chronic bronchitis/emphysema (father)	0.7	0.8	1.4	-1.2	0.9	1.1	0.5	-1.2	-0.6	0.2
Body mass index (BMI)	0.7	2.8	5.4	-2.1	1.5	-0.3	-2.2	0.2	-1.7	-2.3
Trunk fat mass	0.7	2.9	6.6	-1.9	1.1	0.1	-2.6	-1.1	-1.7	-2.1
Number of incorrect matches in round	0.7	1.2	2.6	1.5	1.6	0.9	0.9	1.3	-0.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.1	0.1	-0.7	-1.8	-0.4	-0.6	1.4	-0.3
Hair/balding pattern: Pattern 3	0.7	1.0	4.1	2.0	0.1	-0.2	0.0	0.2	1.5	0.7
Noisy workplace	0.7	0.9	2.4	0.1	-0.1	0.3	0.8	1.6	-1.3	1.1
Mouth/teeth dental problems: Dentures	0.7	1.1	5.5	-0.3	0.0	-1.1	-0.3	-0.5	-2.4	-0.8
Depression (self-reported)	0.7	0.9	3.1	-0.2	1.0	-1.3	-0.6	0.1	0.0	-1.8
Pulse wave Arterial Stiffness index	0.7	0.8	2.8	0.1	0.2	0.1	-0.0	1.7	1.0	1.4
Exposure to tobacco smoke at home	0.7	0.8	3.3	-0.6	-1.8	-0.1	-0.1	-1.0	-0.6	0.8
Pulse wave reflection index	0.7	0.8	3.3	-0.6	-0.9	1.8	-0.3	0.1	-0.4	1.1
Loud music exposure frequency	0.7	0.8	3.2	-0.5	-0.5	0.7	0.9	-1.8	-0.2	0.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.2	1.5	-0.7	1.2	-0.2	-1.1	0.1	0.9
Worry too long after embarrassment	0.7	1.1	3.3	0.8	-0.8	1.5	-0.5	-1.8	0.1	-0.8
Migraine (self-reported)	0.7	0.9	2.9	-0.4	0.9	0.4	0.2	-1.7	-0.8	-1.3
Whole body fat mass	0.7	3.1	6.1	-2.2	1.2	0.1	-2.5	-0.7	-1.8	-2.3
Overall health rating	0.7	1.5	3.7	-1.4	-0.5	1.9	-0.4	-1.4	-1.4	0.6
Family relationship satisfaction	0.7	0.8	3.5	-0.2	-0.3	0.5	0.8	-1.9	0.9	0.7
Friendships satisfaction	0.7	0.8	2.7	-0.4	-0.5	0.2	0.4	-1.6	1.4	0.6
Asthma (self-reported)	0.7	1.4	4.5	0.8	-2.1	-0.6	1.1	-0.9	0.3	1.4
Smoking status: Current	0.7	1.1	1.8	1.0	-0.2	-0.9	-0.9	-1.3	-1.4	-1.2
Risk taking	0.7	1.1	3.2	-0.9	-1.2	-0.5	-1.8	-0.6	0.5	-1.1
Fractured/broken bones in last 5 years	0.7	0.9	2.1	-1.4	-0.2	1.1	-1.3	0.3	0.1	-1.0
Unable to work because of sickness or disability	0.7	0.9	3.4	-0.5	0.5	0.4	0.2	-1.8	-1.4	-0.3
Commuting to job workplace: Cycle	0.7	0.9	2.3	-1.5	-0.6	0.3	0.5	-0.2	1.4	0.9
Heart attack/myocardial infarction (self-reported)	0.7	1.0	2.9	1.7	-0.8	-0.4	0.2	0.7	0.6	1.5
Alzheimer’s Disease (including proxy)	0.6	0.9	2.6	0.9	-1.4	0.7	-0.5	-0.4	1.6	0.2
Coronary Artery Disease (CAD)	0.6	0.7	3.8	0.1	-0.7	0.2	-2.0	0.5	-0.7	-0.4
LDL Cholesterol	0.6	0.9	2.0	0.7	-0.6	-1.0	1.4	-0.7	-0.7	1.3
Lupus	0.6	0.9	2.6	-0.4	-0.4	1.1	1.6	1.3	0.4	0.3
Rheumatoid Arthritis	0.6	0.9	2.1	1.4	0.5	-0.6	1.3	0.5	-0.7	0.9
Neuroticism	0.6	1.6	3.4	1.2	-1.6	1.8	0.4	-1.5	0.3	1.1
Hearing difficulty/problems: Yes	0.6	0.9	2.5	0.5	-0.2	1.2	0.6	1.1	1.6	0.3
Current tobacco smoking	0.6	1.0	1.6	1.0	-0.4	-0.8	-0.9	-1.0	-1.3	-1.1
Age when periods started (menarche)	0.6	1.4	5.4	-1.0	-0.5	-0.1	0.9	-1.4	-2.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.7	0.3	-0.2	0.6	1.0	1.6	0.8	0.4
Medication: Levothyroxine sodium	0.6	1.0	5.2	-0.4	0.1	0.9	0.1	2.3	-0.4	0.8
High blood pressure (mother)	0.6	0.9	2.3	1.5	1.5	-0.0	1.0	-0.9	-0.2	0.3
Waist circumference	0.6	2.3	4.4	-1.9	1.1	0.2	-2.1	0.2	-2.1	-1.5
Had menopause	0.6	0.7	3.9	0.1	2.0	-0.2	0.4	0.8	-0.3	-0.1
Heart attack	0.6	0.8	2.2	1.5	-0.7	-0.4	0.2	0.6	0.7	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.9	1.4	-0.4	0.2	0.6	1.3	-0.2	1.2
Illnesses of mother	0.6	0.7	3.1	-0.4	-1.8	0.7	-0.5	0.3	0.8	0.6
Leg fat percentage (right)	0.6	2.3	5.0	-2.1	1.5	-0.3	-2.0	0.3	-0.8	-2.2
Pulse wave peak to peak time	0.6	0.8	2.3	-0.1	-0.1	-0.3	0.1	-1.5	-0.8	-1.5
Qualifications: College or University degree	0.6	1.8	8.1	1.5	-0.1	0.8	-0.6	-0.7	2.9	-0.8
Leg fat mass (right)	0.6	2.3	5.5	-1.8	1.5	0.1	-2.0	0.5	-1.0	-2.4
Chest pain or discomfort	0.6	0.8	2.6	0.4	-0.7	-0.9	1.6	0.4	1.0	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.5	-0.7	-1.2	1.1	-0.9	-1.0	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.5	-1.0	1.5	0.6	-1.2	-0.0	0.3	-1.9
Eye problems/disorders: Glaucoma	0.6	0.7	1.8	-0.7	-0.3	0.7	1.4	1.0	-0.1	1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.0	-1.0	1.2	-0.1	-0.5	0.9	1.4	0.0
Leg fat percentage (left)	0.6	2.0	4.5	-2.1	0.9	-0.2	-1.9	0.1	-1.0	-2.0
Age started oral contraceptive pill	0.6	0.7	1.9	1.4	-0.3	0.1	0.7	1.1	-1.0	0.4
Ever depressed for a whole week	0.6	0.7	4.0	0.2	-0.5	-2.0	0.2	-0.3	0.3	-0.5
Depressed Affect (Nagel 2018)	0.5	1.1	5.7	-0.5	-2.4	0.6	0.2	-0.5	-0.6	0.6
Schizophrenia (2018)	0.5	1.0	4.3	-0.5	0.8	-0.2	-2.1	-0.0	0.6	-1.2
Reaction Time	0.5	0.9	1.6	1.2	1.0	1.2	0.7	-1.3	-0.4	-0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.9	-0.5	1.0	0.1	-1.1	-0.4	-0.7	-1.4
Neuroticism (2016)	0.5	0.8	1.4	-0.9	0.9	1.0	-0.5	-1.2	-1.0	-0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	3.3	-0.7	-0.2	-0.1	-0.7	-0.9	0.2	-1.8
Relative age of first facial hair	0.5	0.9	3.3	0.2	0.9	1.5	0.3	1.8	-0.3	-0.3
Medication for hormone replacement therapy	0.5	0.6	2.0	-1.0	-0.0	-0.2	-1.4	-0.6	-0.3	-0.6
Medication: Co-codamol	0.5	0.6	1.5	-0.3	0.3	-1.2	0.8	-0.2	1.2	-0.8
Relative age voice broke	0.5	0.7	2.2	1.5	-0.6	1.3	-0.0	0.8	-0.0	0.4
Serious illness, injury or assault to yourself	0.5	0.6	2.5	-1.0	1.6	0.7	-0.1	0.1	-0.2	-0.4
Medication: Atenolol	0.5	0.6	2.2	1.1	-0.7	0.4	0.3	-0.5	-0.3	1.5
Impedance of leg (left)	0.5	2.2	6.2	0.7	-2.0	-0.0	1.6	-0.8	1.2	2.5
Hearing difficulty/problems with background noise	0.5	0.7	3.6	0.5	0.8	1.9	-0.1	-0.3	0.6	0.4
Mouth/teeth dental problems	0.5	0.7	2.2	-0.3	-0.3	0.5	0.7	1.3	1.5	0.0
Weight	0.5	2.3	4.7	-1.7	1.7	0.6	-1.6	0.5	-1.5	-2.2
Worrier / anxious feelings	0.5	1.0	3.4	1.9	-0.3	-0.3	0.9	-1.5	0.3	0.5
Medication: Paracetamol	0.5	0.8	1.7	1.3	-1.3	0.3	0.1	-0.5	-0.5	1.1
Medication for pain relief, constipation, heartburn	0.5	0.9	2.4	-0.1	0.9	-1.6	0.6	0.8	1.2	-0.9
Medication: Ibuprofen	0.5	0.6	1.1	1.0	-0.9	0.3	0.9	0.5	-0.4	1.1
Medication: Omeprazole	0.5	0.6	1.4	0.2	0.4	-1.2	-0.8	-1.1	-0.8	-0.4
Mean time to correctly identify matches	0.5	0.9	3.2	1.8	0.8	1.2	0.7	0.4	0.0	0.4
Suffer from ‘nerves’	0.5	0.8	2.9	-0.2	-0.5	1.7	-0.2	-1.5	0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.9	0.3	-1.4	-0.9	0.2	-1.0	-0.7	1.3
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	-0.3	-0.2	0.8	-0.8	1.1	-1.1	0.3
Average weekly champagne plus white wine intake	0.5	0.7	1.1	0.9	-0.3	-1.0	-1.0	-0.9	1.0	-0.2
Medication: Atorvastatin	0.5	0.7	2.6	0.2	1.2	-0.2	-0.2	1.6	-0.5	0.6
Diastolic blood pressure, automated reading	0.5	1.5	8.7	-0.6	0.8	0.4	3.0	-0.6	-0.5	0.3
Leg fat mass (left)	0.5	2.0	4.2	-2.0	1.1	0.3	-1.9	0.3	-1.0	-2.0
Depression (Nagel 2018)	0.4	0.7	2.3	-1.0	-0.7	0.5	-0.4	-1.5	0.2	-0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	0.4	1.1	0.4	-0.2	1.2	-0.6	0.4
Father’s age at death	0.4	0.6	2.1	0.6	-1.0	-0.8	-0.0	0.4	1.4	0.1
Medication: Lansoprazole	0.4	0.5	2.3	0.6	0.3	0.7	0.5	-1.5	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.6	-1.5	0.9	0.4	-1.4	-0.1	-0.5	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	1.1	0.1	1.2	0.1	-0.3	0.7	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.3	-1.1	0.1	-0.7	1.1	0.3	-0.9	-0.4
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.0	-0.9	-0.3	1.0	-0.2	-1.0	0.2	-0.3
Health satisfaction	0.4	0.5	2.0	-1.1	0.1	-0.0	-1.4	-0.1	-0.4	-0.5
Medication: Blood pressure	0.4	0.6	2.0	1.4	-0.1	0.9	-0.7	-0.7	0.8	0.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.7	0.5	1.3	0.6	0.4	-0.0	-0.7	0.3
Knee pain experienced in last month	0.4	0.6	1.6	-1.0	-1.3	0.5	0.5	0.0	-0.8	0.6
Hypertension (Self-reported)	0.4	1.0	3.9	-0.2	-0.9	-0.1	0.9	-1.1	-2.0	0.8
Smoking status: Previous	0.4	0.6	2.2	-0.2	0.5	-0.9	1.5	-0.5	0.2	0.6
Long-standing illness, disability or infirmity	0.4	0.6	2.3	0.6	-0.6	-0.1	0.9	-0.5	-0.2	1.5
Mineral and other dietary supplements	0.4	0.6	2.0	-0.2	-0.4	0.8	0.3	-0.7	-1.4	-0.8
Number of self-reported non-cancer illnesses	0.4	0.8	3.2	-1.1	-1.8	0.2	0.2	0.1	0.4	0.9
Mother’s age at death	0.4	0.6	1.2	0.7	0.4	-0.9	-0.8	0.7	-1.1	0.0
Systolic Blood Pressure	0.3	1.7	3.5	1.6	-1.9	-0.0	1.6	-0.6	-0.8	1.5
Number of treatments/medications taken	0.3	0.5	1.3	0.5	-0.8	0.8	0.3	-0.5	0.6	1.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	-0.9	0.7	-0.0	0.4	1.1	-0.4	0.2
Systolic blood pressure, automated reading	0.3	1.0	2.5	-0.1	-0.2	-0.1	1.3	1.4	-1.6	0.9
Medication: Metformin	0.3	0.5	1.3	0.9	-0.4	0.5	-1.2	0.5	-0.3	0.6
Impedance of leg (right)	0.3	1.7	4.7	0.8	-1.3	-0.2	1.6	-0.6	1.3	2.2
Leg fat-free mass (left)	0.3	1.8	5.1	-0.8	1.4	0.9	-1.5	0.6	-1.2	-2.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	-0.2	-0.6	-0.5	-0.4	-0.3	-0.3	1.1
High blood pressure	0.3	0.9	2.9	-0.2	-0.8	-0.1	0.8	-1.2	-1.7	0.6
Leg predicted mass (left)	0.3	1.8	5.0	-0.7	1.5	1.0	-1.4	0.7	-1.2	-2.2
Past tobacco smoking	0.3	0.6	1.4	0.5	-0.6	1.0	-0.7	1.2	0.7	0.4
Had other major operations	0.3	0.4	1.3	-0.7	-0.1	1.2	-0.8	-0.4	-0.1	0.3
Diabetes (self-reported)	0.3	0.5	3.0	1.7	0.4	-0.2	0.3	-0.3	0.2	-0.4
Impedance of arm (right)	0.3	1.4	5.7	0.8	-0.3	-1.6	-0.9	-2.4	0.6	0.2
Trunk fat-free mass	0.3	1.7	3.5	-0.5	1.8	1.5	0.1	1.9	-0.8	-1.3
Medication: Cholesterol lowering	0.3	0.5	1.9	0.6	-0.8	0.5	-1.4	-0.2	0.5	0.4
Impedance of arm (left)	0.3	1.5	7.2	0.5	-0.9	-0.6	-1.3	-2.7	0.5	0.6
Trunk predicted mass	0.3	1.8	3.8	-0.5	2.0	1.6	0.1	1.9	-0.7	-1.3
Peak expiratory flow (PEF)	0.3	0.6	1.7	-0.8	0.1	-0.4	-0.7	-1.3	0.2	-1.0
Glaucoma (self-reported)	0.3	0.3	0.8	-0.9	-0.5	0.7	-0.3	0.5	-0.6	-0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	2.4	-1.5	0.8	-0.2	-1.2	-0.3	-0.8	-1.4
Arm fat-free mass (right)	0.3	1.7	5.0	-1.0	0.9	2.2	0.0	1.7	-1.3	-0.8
Comparative body size at age 10	0.3	0.8	3.8	0.4	0.5	1.9	0.2	-0.4	1.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	1.1	0.8	-0.3	-0.2	0.6	-0.5	-0.0
Wheeze or whistling in the chest in last year	0.3	0.6	1.2	0.6	-0.5	-0.8	0.8	-1.1	0.2	0.9
Neck or shoulder pain in last month	0.3	0.4	1.5	0.1	-0.0	-0.2	0.5	1.0	-1.2	0.0
Medication: Allopurinol	0.3	0.4	1.3	-1.1	-0.4	-0.9	-0.7	0.3	-0.2	-0.1
Arm predicted mass (right)	0.3	1.6	4.7	-1.0	0.8	2.2	0.1	1.5	-1.2	-1.0
Comparative height size at age 10	0.3	1.8	6.6	1.0	-0.2	2.6	0.5	0.8	1.7	1.2
Medication: Aspirin	0.3	0.4	1.3	0.4	0.1	0.5	-1.0	-0.5	-1.2	-0.4
Whole body fat-free mass	0.3	1.5	2.5	-0.6	1.5	1.6	-0.3	1.4	-1.0	-1.6
Leg fat-free mass (right)	0.3	1.3	3.4	-0.6	1.0	1.3	-1.3	0.5	-1.0	-1.8
Diabetes diagnosed by doctor	0.3	0.5	2.2	1.5	0.1	-0.9	0.0	-0.6	-0.2	0.2
Whole body water mass	0.3	1.5	2.6	-0.6	1.5	1.6	-0.3	1.3	-0.9	-1.6
Leg predicted mass (right)	0.3	1.4	3.8	-0.7	1.1	1.3	-1.4	0.5	-1.0	-1.9
Medication: Bendroflumethiazide	0.3	0.5	1.0	0.9	-0.0	-1.0	0.3	0.9	0.2	0.7
Basal metabolic rate	0.3	1.5	3.0	-0.9	1.4	1.3	-0.7	1.1	-1.1	-1.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.3	-0.5	1.1	-0.0	-1.2	0.6	1.1	-1.0
Alcohol drinker status: Previous	0.3	0.4	1.8	-0.1	-1.4	0.7	-0.4	-0.0	0.1	0.2
Impedance of whole body	0.3	1.7	3.7	0.8	-1.6	-0.6	0.3	-1.9	1.2	1.8
Crohns Disease (2012)	0.2	0.3	0.9	0.2	-0.9	0.3	0.5	-0.6	0.7	0.3
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.2	-0.7	0.7	0.6	0.2	0.0	0.6
Blood White Count	0.2	1.8	5.2	-0.2	-2.0	-2.3	-0.3	-1.1	-1.4	0.3
Height	0.2	3.7	10.9	0.5	1.4	2.7	1.6	3.3	1.7	0.5
Respiratory disease	0.2	0.4	2.0	0.1	-1.4	0.4	0.1	-0.0	-0.4	0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.8	0.6	0.0	-0.4	-0.9	-0.2	-0.6	-0.6
Lung FEV1/FVC ratio	0.2	0.8	3.6	0.6	0.8	0.5	-0.8	0.1	0.2	-1.9
Vitamin and mineral supplements	0.2	0.3	1.8	0.5	-0.3	-0.3	1.4	-0.1	-0.0	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.8	-0.3	0.9	0.8	-0.1	-0.2	-0.4	-0.1
Multivitamins +/- minerals	0.2	0.3	0.6	-0.2	-0.1	0.6	-0.5	-0.5	0.5	0.8
Forced vital capacity (FVC)	0.2	0.6	1.3	-0.9	0.8	-0.1	-0.2	-1.1	-0.7	-1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.2	-1.1	0.7	0.3	-0.8	-0.8	-0.4	-1.5
Exposure to tobacco smoke outside home	0.2	0.3	0.7	0.6	-0.6	-0.4	0.7	0.2	0.2	0.8
Emphysema/chronic bronchitis	0.2	0.3	1.0	1.0	-0.0	-0.4	0.3	0.4	0.5	0.6
Leg pain on walking	0.2	0.2	0.8	-0.4	-0.5	0.4	-0.1	-0.1	-0.9	-0.2
Illnesses of siblings: Diabetes	0.2	0.3	0.8	-0.6	-0.3	-0.9	0.3	-0.5	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.4	-1.2	1.2	0.1	-0.2	-0.5	0.3	0.0
Osteoporosis (self-reported)	0.2	0.2	1.3	0.1	-0.0	1.1	-0.2	0.0	-0.1	0.5
Wears glasses or contact lenses	0.2	0.3	0.6	-0.6	-0.2	-0.5	0.3	-0.8	0.4	-0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.3	0.2	-0.1	0.5	1.1	-0.2	0.2	0.1
High cholesterol (Self-reported)	0.2	0.4	1.1	0.2	0.2	-0.2	-1.1	1.0	-0.1	0.6
Illnesses of father: High blood pressure	0.2	0.2	0.8	0.3	-0.3	0.8	-0.1	-0.4	0.9	0.0
Ever smoked	0.2	0.3	1.1	-0.8	-0.1	-1.0	0.4	-0.6	-0.1	-0.0
Arm fat-free mass (left)	0.2	1.2	3.0	-0.4	1.1	1.6	0.5	1.7	-0.8	-0.9
Number of operations (self-reported)	0.2	0.3	0.6	-0.4	-0.5	-0.7	-0.5	0.4	0.7	-0.2
Arm predicted mass (left)	0.2	1.2	4.5	-0.5	0.9	1.3	0.5	2.1	-0.6	-0.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.8	-0.8	-0.0	0.1	-0.7	-0.6	0.1
Blood Red Count	0.1	0.8	3.2	0.6	0.2	-1.8	1.2	-0.4	-0.3	0.0
Lung FVC	0.1	0.7	3.0	-0.3	0.8	-1.7	-0.2	-0.5	0.0	-0.9
Hair Pigment	0.1	1.5	3.2	1.8	0.1	1.8	1.6	-0.9	-0.3	0.9
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.5	-0.1	0.5	-0.0	0.4	-0.2	-0.6
Sitting height	0.1	0.6	1.7	-0.3	1.3	0.7	1.3	-0.5	-0.1	-0.3
Standing height	0.1	0.9	3.1	0.6	0.7	1.8	1.1	0.9	0.2	0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	-0.8	-0.0	-1.0	-0.0	-0.5	0.3	-0.0
Gout (self-reported)	0.1	0.2	0.8	-0.4	-0.9	-0.5	-0.1	0.2	0.1	0.2
Medication: Paracetamol	0.1	0.1	0.3	0.6	0.2	0.6	0.2	0.2	-0.1	0.1
Heart disease (siblings)	0.1	0.2	0.6	0.4	-0.3	-0.4	0.3	0.8	0.3	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.4	0.9	-0.7	0.9	0.5	0.9	0.5	-0.4	-0.5

Hub : Genes

USP15

Models

Trait associations