Hub : Genes

USP47

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1420	0.0560	6.3e-03	0.063	NA	0.034	NA	0.066	1.7e-05	NA	1.4e-03	NA	1.1e-05
2	GTEx	Esophagus Mucosa	0.2420	0.0490	5.2e-08	0.181	NA	0.145	NA	0.174	3.5e-12	NA	6.7e-10	NA	9.4e-12
3	ROSMAP	Brain Pre-frontal Cortex	0.0515	0.0216	1.1e-02	0.070	0.010	0.045	0.046	0.053	2.5e-09	1.8e-02	1.6e-06	1.2e-06	2.3e-07
4	YFS	Blood	0.0522	0.0121	7.0e-09	0.054	0.035	0.051	0.052	0.052	3.0e-17	1.3e-11	2.1e-16	1.2e-16	1.0e-16
5	TCGA	Brain Lower Grade Glioma	0.0581	0.0256	1.2e-03	0.014	0.020	0.023	NA	0.015	8.3e-03	1.9e-03	9.8e-04	NA	7.1e-03
6	TCGA	Prostate Adenocarcinoma	0.0550	0.0239	9.2e-04	0.011	0.028	0.015	NA	0.022	2.3e-02	6.2e-04	1.0e-02	NA	1.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.2	1.8	4.4	0.0	1.5	2.1	1.4	-0.7	1.4
Bipolar Disorder or Schizophrenia	0.7	1.6	4.0	-0.1	1.6	2.0	1.4	-0.6	0.9
Depressed Affect (Nagel 2018)	0.5	1.1	2.8	-0.3	-1.2	-0.6	-1.3	-1.7	-0.5
Depression (Nagel 2018)	0.5	0.7	1.6	0.9	-0.6	-1.3	-0.4	-0.4	-1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.6	-1.6	-0.3	1.2	0.6	1.1	0.5
Neuroticism (Nagel 2018)	0.2	0.5	2.3	-0.1	-0.6	-0.2	-0.1	-1.5	0.8
Schizophrenia (2018)	0.2	0.4	0.8	-0.2	0.9	0.9	0.7	-0.1	-0.0
Schizophrenia vs Biploar Disorder	0.9	1.2	2.9	1.7	1.1	-1.0	0.8	-1.0	-0.7
Worry (Nagel 2018)	0.6	1.2	3.0	0.8	1.0	0.7	0.9	-1.1	1.7
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	0.4	1.1	-0.1	1.1	0.3	-0.3
Alzheimer’s Disease (in father)	2.2	2.4	6.4	1.0	-1.5	-2.5	-0.9	-1.7	-1.1
Alzheimer’s Disease (including proxy)	1.2	1.8	5.2	1.0	-0.8	-2.3	-0.7	-0.2	-1.9
Crohns Disease (2017)	0.2	0.5	1.3	-0.9	0.7	1.1	0.2	-0.5	-0.1
Irritable Bowel Disease (IBD)	0.3	0.7	2.0	-0.4	1.2	1.4	0.7	-0.1	-0.2
Ulcerative Colitis (UC)	0.3	0.7	1.7	0.6	1.3	0.9	0.9	0.6	-0.1
Major Depression (MDD)	0.3	0.4	1.2	-0.4	-0.1	0.2	-0.4	-0.8	-1.1
Reaction Time	0.6	1.1	2.6	-0.8	-1.0	0.6	-0.4	1.6	1.5
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.0	-2.0	-0.3	1.9	0.9	0.6	0.4
Breast Cancer	0.8	1.9	5.2	-1.8	-0.1	2.3	0.3	-0.9	1.5
Ovarian Cancer	0.3	0.5	2.0	-0.5	0.3	0.0	-0.3	-0.6	-1.4
Prostate Cancer	0.3	0.5	1.2	-1.1	0.1	1.0	0.1	0.9	0.1
Age at First Birth	0.4	0.6	2.1	0.9	0.1	-0.7	0.1	1.4	-0.4
Bipolar Disorder (2011)	0.8	0.8	2.5	-1.6	-1.3	0.8	0.0	0.0	-0.2
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	-0.9	0.3	1.1	-0.4	-0.1	0.3
Coronary Artery Disease (CAD)	1.4	1.7	3.5	0.3	-1.0	-1.5	-1.9	0.4	-1.7
Crohns Disease (2012)	0.7	1.2	3.3	-1.2	-1.0	-0.0	-1.8	0.9	-0.5
Mean Putamen Volume	0.2	0.2	0.6	-0.5	-0.8	0.3	-0.0	-0.1	-0.5
Fasting Glucose	0.9	1.1	2.8	0.8	-0.4	0.2	-1.4	-1.7	-0.8
HbA1C	1.1	1.2	4.8	-0.9	-0.6	-2.2	0.3	0.7	0.9
HDL Cholesterol	0.7	1.1	2.3	0.9	1.5	0.6	1.4	-0.2	1.1
LDL Cholesterol	0.3	0.4	1.0	0.8	1.0	0.0	0.5	-0.8	-0.2
Lupus	3.2	4.9	9.4	-2.1	-3.1	-0.3	-3.0	2.2	-1.2
Neuroticism (2016)	1.6	2.4	4.3	1.2	2.1	1.9	1.3	-1.0	1.5
Primary Biliary Cirrhosis	0.4	0.6	1.9	0.4	-0.0	-1.4	-0.3	1.0	0.5
Rheumatoid Arthritis	0.4	0.6	1.2	-1.0	0.0	0.9	1.1	0.3	0.6
Schizophrenia (2014)	0.1	0.3	0.6	-0.3	0.8	0.8	0.7	-0.3	0.0
Triglycerides	1.3	2.1	4.1	-0.7	-2.0	-1.3	-1.9	-0.5	-1.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.0	-0.1	1.0	1.0	0.6	0.1	0.4
Ulcerative Colitis	0.5	0.8	2.3	-0.9	-0.3	0.5	-0.6	1.5	-1.0
Blood Eosinophil Count	0.9	7.2	14.4	-1.6	2.8	3.8	3.1	1.5	2.6
Blood Platelet Count	0.5	6.2	9.8	0.7	3.0	2.7	2.0	-2.7	3.1
Blood Red Count	0.1	1.4	4.0	-1.6	-0.8	2.0	-1.0	0.3	-0.4
Blood White Count	1.0	7.1	20.2	-1.8	2.3	4.5	1.5	-1.5	3.0
Heel T-Score	0.7	5.4	12.5	-2.2	-3.5	-0.1	-2.5	1.3	-2.6
BMI	1.0	5.8	18.7	0.7	3.4	1.8	0.7	-4.3	0.6
Height	0.4	7.8	39.1	1.3	-0.1	-1.2	2.2	6.2	0.0
Waist Hip Ratio (WHR)	0.8	3.6	9.2	2.7	1.3	-1.7	0.1	-0.7	-3.0
Systolic Blood Pressure	0.5	2.5	7.5	2.7	1.6	-0.7	0.7	-1.7	-0.9
Smoking Status	0.1	0.2	0.9	0.1	0.1	-0.1	0.5	-1.0	-0.3
Allergy or Eczema	0.3	0.9	1.6	-0.2	0.9	0.2	1.1	1.2	1.3
Cardiovascular Disease	0.3	1.0	2.6	1.1	0.6	-0.7	-0.7	-0.7	-1.6
Hypothyroidism (self reported)	1.4	3.3	7.0	1.2	2.7	1.4	2.5	0.3	1.6
Respiratory disease	0.3	0.7	2.2	-1.1	0.6	1.5	0.0	-0.2	0.8
Type 2 Diabetes (T2D) (2018)	0.7	1.2	4.0	0.9	2.0	0.9	0.9	-0.8	0.6
Lung FEV1/FVC ratio	0.1	0.6	2.3	-0.3	0.0	1.5	-0.4	-0.4	0.8
Lung FVC	1.3	6.4	16.6	-4.1	-4.0	0.9	-1.3	1.7	0.3
Neuroticism	0.3	0.6	2.9	-0.0	-0.6	0.1	-0.7	-1.7	0.3
Chronotype (morning person)	0.5	1.2	2.7	0.9	1.4	0.3	1.6	-0.7	1.1
Hair Pigment	0.0	0.5	1.5	1.2	1.2	-0.5	-0.1	0.1	-0.4
Tanning	0.3	3.3	7.8	-1.7	-2.3	-0.8	-1.3	2.8	-1.2
Hand grip strength (left)	0.1	0.3	1.0	-0.3	-0.1	0.1	-0.5	0.8	1.0
Number of treatments/medications taken	0.5	0.9	2.3	1.3	1.5	0.1	0.4	-1.2	0.0
Average weekly spirits intake	2.3	2.9	7.0	1.1	2.7	1.1	2.1	-1.5	1.0
Sensitivity / hurt feelings	0.5	0.9	1.7	1.2	0.7	0.1	1.2	-0.4	1.3
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.7	1.3	0.6	-0.5	0.3	-1.1	-0.1
Hearing difficulty/problems: Yes	0.2	0.3	1.0	-0.3	-0.5	-0.5	0.1	1.0	0.3
Relative age of first facial hair	0.5	1.1	4.3	-1.1	-0.5	0.7	0.4	2.1	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.2	1.0	1.5	0.4	0.9	-0.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.4	1.2	0.4	-1.6	1.3	-0.3	-0.5
Ever had hysterectomy (womb removed)	0.8	0.9	2.4	-0.3	-1.2	-1.2	-0.1	0.4	-1.6
Systolic blood pressure, automated reading	0.9	2.5	7.6	1.8	1.9	0.4	0.6	-2.8	-0.3
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	5.2	2.2	2.3	-1.0	1.5	-1.6	0.6
Angina	0.9	1.2	2.7	1.3	1.6	-0.2	1.4	-1.0	-0.4
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.2	-0.0	-0.3	0.3	0.0	0.1
Vitamin and mineral supplements	0.4	0.5	1.2	-0.7	-0.8	-0.1	-1.1	-0.8	0.0
Supplements: Zinc	1.7	1.9	3.7	-1.9	-0.5	1.9	-1.2	1.4	0.5
Medication: Co-codamol	1.1	1.3	5.6	-0.2	-0.8	-0.8	-0.9	-2.4	-0.2
Medication: Metformin	0.7	0.9	2.7	0.7	0.9	0.1	-0.1	-1.6	-1.2
Diabetes (father)	1.7	2.1	6.6	0.8	1.6	0.5	2.6	0.3	1.4
Diabetes (mother)	1.5	2.0	4.6	2.1	0.9	-0.8	1.1	-2.1	0.5
Severe depression (siblings)	0.3	0.3	0.9	-0.6	-0.4	0.0	-0.9	-0.2	-0.6
Pack years adult smoking proportion	0.4	0.6	2.1	0.2	1.4	0.9	0.2	-0.7	0.0
Impedance of leg (right)	0.5	2.3	8.5	2.9	0.7	-1.7	0.5	-0.0	-1.1
Leg fat-free mass (left)	0.2	0.9	2.1	0.4	1.5	0.7	0.5	-1.2	0.8
Trunk fat percentage	1.5	6.1	15.5	3.0	3.1	-0.5	1.5	-3.9	-0.0
Hand grip strength (right)	0.2	0.4	1.2	-0.2	-0.4	-0.8	-0.6	1.1	0.3
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.7	0.2	-0.7	0.6	-0.4	-0.4
Current tobacco smoking	0.1	0.2	0.6	-0.4	-0.7	-0.2	-0.1	-0.1	-0.3
Average weekly fortified wine intake	0.2	0.3	0.9	0.5	0.4	0.6	0.2	0.2	1.0
Maternal smoking around birth	1.3	1.9	6.4	1.8	-0.7	-2.5	-0.2	-0.4	-0.9
Fed-up feelings	0.6	1.1	3.5	0.3	-0.6	-1.4	-0.4	-1.9	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	1.1	-0.4	-1.1	-0.1	0.1	-0.1
Relative age voice broke	0.6	0.9	3.6	0.3	1.0	0.9	1.9	-0.2	0.4
Taking other prescription medications	0.3	0.5	1.4	0.7	1.2	0.1	0.5	0.8	-0.4
Age when periods started (menarche)	0.2	0.5	1.1	-1.1	-0.8	0.6	-0.1	1.1	0.0
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	4.6	0.9	-0.3	-1.4	-0.4	-1.2	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.6	-1.2	-0.6	0.4	-0.6	0.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.7	-0.1	0.4	-0.5	-0.6	0.5
Qualifications: CSEs or equivalent	0.5	0.7	2.1	1.4	1.1	0.1	0.7	-0.8	0.2
Serious illness, injury or assault to yourself	0.5	0.6	1.0	0.8	0.5	0.1	1.0	1.0	0.7
High blood pressure	0.4	1.1	3.1	1.6	1.1	-0.3	0.3	-1.8	-0.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.0	-1.0	-0.1	0.0	-0.1	1.4	-0.1
Multivitamins +/- minerals	0.9	1.2	2.7	0.9	1.5	1.0	1.6	0.1	0.5
Stomach or abdominal pain in last month	0.3	0.4	1.2	1.1	0.7	-0.2	-0.2	-0.5	0.4
Supplements: Glucosamine	1.2	1.6	3.3	-1.8	-1.7	0.4	-1.2	1.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.1	0.2	-0.3	0.0	-0.5	-0.3
Medication: Atenolol	0.5	0.6	1.7	1.2	1.3	-0.1	-0.0	-0.3	-0.6
Medication: Levothyroxine sodium	0.7	1.2	1.9	0.6	1.3	0.7	1.4	1.3	0.9
Sitting height	0.2	1.1	2.6	-1.6	-1.5	0.3	-1.0	1.0	0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	0.0	0.7	0.9	0.1	-0.2	0.4
High blood pressure (mother)	2.5	3.6	12.7	1.9	1.7	-1.1	1.1	-3.6	0.2
Body mass index (BMI)	1.2	5.3	18.4	0.8	3.0	1.4	1.1	-4.3	0.8
Impedance of leg (left)	0.5	2.6	9.7	3.1	0.6	-2.0	1.0	0.4	-0.7
Leg predicted mass (left)	0.2	0.9	2.3	0.5	1.5	0.6	0.6	-1.2	0.9
Trunk fat mass	1.4	6.2	14.1	3.0	3.4	-0.0	1.6	-3.8	0.4
Waist circumference	1.5	5.5	12.6	2.4	3.5	0.6	1.5	-3.6	-0.1
Number of incorrect matches in round	0.6	1.1	2.7	-0.3	0.9	1.4	1.0	-0.1	1.6
Past tobacco smoking	0.3	0.5	2.1	-0.5	0.0	0.4	-0.2	1.5	0.6
Alcohol usually taken with meals	0.3	0.5	0.9	-0.8	-0.7	0.5	-0.8	1.0	-0.4
Nervous feelings	0.5	0.9	2.6	0.7	0.6	0.9	0.5	-0.9	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.1	-0.8	-0.6	-0.7	-0.4	-0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.1	-0.6	-0.7	-0.8	-0.4	0.3
Hair/balding pattern: Pattern 2	1.6	2.1	5.3	-0.9	-1.3	-0.0	-2.0	2.3	-0.9
Had menopause	0.5	0.6	2.3	0.3	0.1	-1.0	0.6	1.5	0.1
Had other major operations	1.3	1.6	6.3	-0.9	1.3	2.5	0.6	0.0	0.7
Forced vital capacity (FVC)	0.4	1.7	6.7	-1.0	-2.6	-0.9	-0.5	1.2	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	-1.0	-0.3	0.8	-0.2	0.6	-0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.3	0.5	-0.3	-0.3	-1.1	-1.5	-0.9
Qualifications: None of the above	1.1	2.3	4.8	0.2	-1.6	-1.9	-2.2	-0.5	-1.6
Financial difficulties in last 2 years	1.7	2.3	5.7	1.7	2.4	0.8	1.6	-0.3	1.5
Mouth/teeth dental problems	1.3	2.0	4.9	-1.4	-2.2	-0.4	-2.0	0.9	-0.5
Heart attack	0.6	0.8	2.1	0.6	0.2	-0.0	-0.6	-1.3	-1.4
Allergy	0.3	0.7	1.9	1.4	0.0	-0.9	0.4	-1.2	-0.1
Pain all over the body in last month	0.2	0.2	0.6	0.4	-0.3	-0.7	0.0	0.2	-0.6
Diabetes (self-reported)	1.5	2.3	6.9	1.4	2.6	1.4	1.0	-1.4	0.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.1	1.5	1.8	-0.5	1.5	0.9	1.2
Medication: Ramipril	0.6	0.8	1.6	0.8	1.1	1.3	0.5	-0.6	0.8
Medication: Simvastatin	1.5	2.3	5.5	2.3	1.4	-1.6	-0.3	-1.6	-1.0
Fluid intelligence score	0.4	0.9	2.8	-0.5	0.7	1.7	1.1	0.2	0.7
Illnesses of siblings	2.3	3.2	8.1	-1.6	-2.8	-1.0	-1.9	1.9	-0.8
Neuroticism score	0.4	0.8	3.3	0.4	0.3	0.5	0.2	-1.8	1.0
Weight	0.8	4.1	9.7	1.9	3.1	0.7	1.6	-2.8	0.9
Impedance of arm (right)	0.8	3.9	7.5	2.7	-0.6	-2.7	-0.0	2.2	-1.8
Arm fat percentage (right)	1.3	5.3	14.8	2.3	3.1	0.4	1.1	-3.9	0.4
Trunk fat-free mass	0.3	1.7	3.3	0.1	1.8	1.8	1.2	-0.0	1.6
Hip circumference	0.5	2.1	4.7	0.7	2.2	1.1	1.2	-1.8	1.3
Time employed in main current job	1.3	1.5	4.4	-1.2	-1.1	1.1	0.5	2.1	0.7
Alcohol intake versus 10 years previously	0.2	0.3	1.3	-0.2	0.4	0.5	0.2	-1.1	-0.4
Father’s age at death	0.6	0.9	3.7	-0.8	0.0	1.9	-0.7	0.4	0.3
Worrier / anxious feelings	0.9	1.6	4.8	-0.5	0.5	1.8	1.1	0.2	2.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.2	1.8	0.7	-0.6	0.6	-1.3	0.0
Falls in the last year	0.6	0.8	1.9	-0.3	0.1	0.0	-1.0	-1.3	-1.4
Hair/balding pattern: Pattern 3	1.6	2.4	3.7	1.9	0.4	-1.9	1.8	-1.8	0.6
Number of live births	0.9	1.2	2.8	-1.7	-1.3	1.1	-1.2	0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	10.5	-1.3	-3.2	-1.2	-1.0	1.2	-0.5
Pulse rate	1.4	2.4	5.2	-1.9	-2.3	-0.1	-2.0	-0.8	-1.0
Happiness	1.3	1.5	3.1	-0.6	0.6	1.8	1.5	1.4	1.0
Noisy workplace	1.4	1.8	3.9	1.3	-0.2	-1.9	-0.8	-2.0	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.6	1.1	1.6	0.1	0.3	-0.4	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.1	-0.7	-0.1	-0.3	0.5	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	1.8	0.2	0.5	-0.3	0.5	-1.4	-0.8
Asthma	0.2	0.5	1.6	-0.9	0.4	1.3	-0.1	0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.8	0.9	1.3	-0.1	1.0	-1.3	0.6
Medication: Cholesterol lowering	0.9	1.4	2.9	1.7	1.6	0.2	1.0	-1.1	0.6
Depression (self-reported)	0.4	0.5	1.5	1.2	0.6	-0.7	0.5	0.2	-0.4
Medication: Lansoprazole	0.6	0.7	2.2	0.6	-0.3	-1.0	0.3	-1.5	-0.6
Prospective memory result	0.4	0.5	0.8	-0.5	0.7	0.9	-0.7	0.5	-0.8
Lung cancer (father)	0.8	1.0	2.2	-1.3	-1.0	0.3	-0.5	1.5	0.9
Illnesses of mother	1.2	1.5	2.7	-1.3	-1.1	0.8	-1.5	1.6	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	6.6	-1.5	-2.6	-0.3	-1.0	1.7	-0.3
Pulse wave Arterial Stiffness index	1.3	1.6	4.7	0.1	1.2	0.5	1.7	-0.5	2.2
Impedance of arm (left)	0.9	4.2	8.7	2.7	-0.7	-2.9	-0.2	2.1	-2.0
Arm fat mass (right)	1.2	4.9	13.0	1.9	3.1	0.6	1.3	-3.6	0.7
Trunk predicted mass	0.3	1.5	3.0	0.1	1.7	1.7	1.1	-0.0	1.5
Standing height	0.3	3.1	8.8	2.6	0.7	-1.3	1.2	3.0	-0.1
Length of working week for main job	0.6	0.7	3.5	-0.4	0.1	0.2	-0.3	-0.7	-1.9
Exposure to tobacco smoke at home	1.2	1.3	3.3	-1.5	-0.1	1.8	-0.3	-1.2	0.8
Breastfed as a baby	1.7	2.1	4.6	-1.7	-2.1	-0.8	-1.7	1.3	-0.3
Tense / ‘highly strung’	0.9	1.4	2.3	1.4	1.5	-0.2	0.7	-1.3	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	5.2	-1.2	1.0	2.3	-0.3	-1.3	0.3
Hair/balding pattern: Pattern 4	0.4	1.0	3.4	-0.2	0.6	1.2	0.8	0.3	1.8
Birth weight of first child	0.7	1.3	5.0	0.6	-0.5	-1.2	-0.9	-2.2	0.2
Peak expiratory flow (PEF)	0.2	0.5	1.2	-0.3	-1.0	0.1	0.9	0.4	1.1
Pulse wave reflection index	1.9	2.3	5.5	0.4	1.7	0.9	2.4	-0.0	2.2
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.7	0.9	-0.5	-1.6	-0.9	-1.6	-1.4
Loud music exposure frequency	0.6	0.7	1.3	1.1	0.3	0.2	0.6	-1.0	1.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.3	1.5	0.9	-1.1	1.1	0.8	0.4
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	4.1	-1.1	0.6	2.0	1.0	1.1	1.3
Blood clot in the leg (DVT)	0.3	0.4	1.1	1.1	0.0	-0.5	-0.4	-0.3	0.7
Medication: Paracetamol	0.5	0.8	1.9	-0.2	-0.9	-1.1	-0.5	0.9	-1.4
Headache pain in last month	0.5	0.9	2.4	-0.2	0.8	0.5	1.4	-0.1	1.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	-1.2	-1.0	0.1	0.4	1.2	0.3
Glaucoma (self-reported)	0.4	0.5	1.4	-0.1	0.0	1.0	0.3	-0.5	1.2
Gout (self-reported)	0.4	0.6	1.2	0.4	1.0	1.0	-0.4	-1.1	0.3
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.8	0.7	2.2	1.2	1.8	0.8	1.2
Medication: Amlodipine	1.8	2.5	9.9	1.3	1.7	0.2	0.5	-3.1	-0.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	-0.7	-0.1	1.2	-0.1	1.0	0.1
Birth weight	0.4	0.9	2.2	-1.5	-1.5	-0.1	-1.1	0.3	-0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.4	-0.4	-0.7	0.2	0.6	-0.2
High blood pressure (siblings)	1.6	2.3	4.6	1.1	2.1	0.5	1.4	-2.2	1.2
Forced vital capacity (FVC), Best measure	0.7	2.4	6.0	-1.6	-2.5	-0.3	-0.8	2.3	-0.1
Body fat percentage	1.7	6.6	17.7	2.9	3.4	-0.0	1.5	-4.2	0.1
Leg fat percentage (right)	2.0	7.3	20.5	2.4	3.8	0.8	1.4	-4.5	0.3
Arm fat-free mass (right)	0.4	2.0	4.1	0.5	2.0	1.2	1.2	-1.4	1.5
Exposure to tobacco smoke outside home	0.8	1.0	3.6	0.7	0.8	1.0	0.4	-1.9	0.4
Comparative body size at age 10	0.4	1.0	2.4	-1.5	-1.4	-1.0	-0.9	0.4	-0.1
Number of full brothers	0.9	1.2	3.4	0.5	1.0	1.3	-0.5	-1.9	-0.5
Worry too long after embarrassment	0.9	1.4	4.3	0.3	0.6	1.5	0.6	-1.1	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.5	-0.9	0.3	1.2	-0.4	-0.1	-0.2
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	0.5	0.9	0.9	1.2	0.0	0.7
Number of children fathered	1.4	1.6	4.1	0.3	0.7	0.5	-1.2	-1.8	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.4	-0.4	-1.2	-1.1	-0.5	1.2	-0.9
Age at first live birth	2.7	4.8	14.0	-2.4	-0.8	2.5	-0.3	3.7	1.5
Pulse wave peak to peak time	1.2	1.4	4.2	0.2	-1.1	-0.6	-1.4	0.7	-2.0
Health satisfaction	1.6	2.1	5.6	2.1	2.4	0.2	1.4	-0.8	-0.3
Shortness of breath walking on level ground	2.2	2.6	10.2	1.7	1.4	-0.4	-0.3	-3.2	-0.6
Qualifications: College or University degree	0.3	1.0	2.1	-1.4	-0.7	0.6	0.6	1.4	1.0
Eye problems/disorders: None of the above	2.9	3.3	5.4	-0.8	-2.3	-1.9	-2.1	0.7	-2.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.9	0.7	1.4	0.6	1.0	0.3	0.2
Emphysema/chronic bronchitis	0.7	0.8	2.0	-0.6	0.4	1.0	-0.6	-1.4	-0.9
Medication for pain relief, constipation, heartburn	0.6	1.0	1.8	-0.9	-0.6	1.4	-0.7	0.6	1.4
Neck or shoulder pain in last month	2.2	3.1	7.1	2.5	2.7	-0.4	1.6	-1.4	0.8
Medication: Blood pressure	0.4	0.7	1.7	0.7	1.3	0.7	-0.0	-1.3	0.3
Angina (self-reported)	0.9	1.2	2.6	1.2	1.6	-0.2	1.5	-0.9	-0.1
Migraine (self-reported)	0.6	0.8	1.8	1.3	0.6	-1.2	0.3	-0.8	0.6
Medication: Ibuprofen	1.2	1.5	2.9	1.1	1.5	0.1	1.2	-1.7	1.0
Medication: Allopurinol	0.6	0.8	2.3	0.3	0.9	1.5	0.1	-0.8	1.0
Medication: Omeprazole	2.0	2.4	6.9	1.1	2.1	0.7	0.6	-2.6	1.0
Medication: Seretide 50 evohaler	0.3	0.3	1.1	0.4	-0.2	0.1	-0.6	-0.5	-1.0
Mean time to correctly identify matches	0.8	1.4	3.2	-0.9	-1.8	0.1	-0.4	1.7	1.3
Heart disease (mother)	2.9	3.6	7.0	-0.2	2.7	2.6	1.9	-1.3	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	1.3	0.1	-0.4	1.1	1.0	0.2
Whole body fat mass	1.5	6.3	15.8	2.5	3.5	0.6	1.6	-4.0	0.7
Leg fat mass (right)	1.8	6.8	18.6	2.2	3.7	1.0	1.4	-4.3	0.7
Arm predicted mass (right)	0.3	1.6	2.9	0.4	1.7	1.1	1.1	-1.4	1.4
Pulse rate, automated reading	0.6	1.8	3.6	-1.2	-1.7	-0.4	-1.9	-1.2	-1.1
Alcohol intake frequency.	2.0	4.7	13.4	2.6	1.8	-1.3	1.3	-3.7	1.1
Comparative height size at age 10	0.3	1.9	6.2	2.5	1.0	-1.4	0.8	1.1	-0.4
Number of full sisters	2.0	2.4	5.6	-1.4	-2.4	-1.3	-1.6	-0.4	-1.6
Suffer from ‘nerves’	0.8	1.2	4.4	0.3	0.8	0.9	-0.1	-1.2	2.1
Overall health rating	1.7	3.7	7.9	2.1	2.8	1.2	2.3	-1.6	0.8
Chest pain or discomfort	0.7	1.0	3.2	0.6	0.6	-0.4	1.1	-1.8	0.7
Had major operations	0.7	0.9	1.7	1.3	0.8	-1.1	0.9	-1.1	0.1
Age at last live birth	1.4	2.1	5.1	-1.9	-1.4	0.7	-1.0	2.3	0.4
Family relationship satisfaction	0.6	0.7	1.1	-0.1	0.8	1.1	1.0	0.8	0.9
Leg pain on walking	1.2	1.5	5.4	2.3	1.3	-0.6	0.9	-0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	6.4	1.6	1.3	-0.5	0.4	-2.5	-0.9
Commuting to job workplace: Car/motor vehicle	1.9	2.2	4.3	-2.1	-2.0	0.5	-1.0	1.5	-1.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.1	-1.7	-0.4	1.3	-0.3	-1.8	1.2
Medication: Aspirin	0.9	1.2	3.1	1.2	1.2	-1.0	1.8	-0.3	-0.0
Supplements: Vitamin C	0.8	0.9	3.0	-0.9	-0.1	0.6	0.8	1.7	0.9
Knee pain experienced in last month	0.7	1.2	2.5	1.6	1.6	-0.2	0.8	-1.1	-0.2
Hypertension (Self-reported)	0.5	1.4	4.1	1.6	1.2	-0.2	0.1	-2.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	3.6	1.0	1.9	0.1	1.6	-1.6	0.9
Illnesses of father: Heart disease	2.2	3.1	6.7	2.6	2.0	-1.0	2.3	-0.7	1.1
Illnesses of siblings: Diabetes	0.5	0.7	1.3	-0.2	1.1	1.0	1.1	0.2	0.5
Smoking status: Previous	1.0	1.5	3.2	1.2	1.5	0.4	1.3	-1.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	1.3	-0.3	-1.3	-0.2	-0.2	-1.1
Whole body fat-free mass	0.2	1.3	2.8	0.3	1.7	1.3	1.1	-0.4	1.5
Leg fat-free mass (right)	0.1	0.6	1.4	0.3	1.2	0.6	0.6	-0.6	1.0
Arm fat percentage (left)	1.4	5.4	16.7	2.3	3.0	0.2	1.1	-4.1	0.4
Average weekly red wine intake	0.6	0.8	1.9	-1.1	-0.2	0.9	-0.7	1.4	-0.7
Handedness (chirality/laterality): Left-handed	1.7	2.1	5.1	-1.3	0.4	1.3	1.1	1.5	2.2
Mood swings	0.3	0.5	1.6	-0.0	-0.7	-0.2	-1.3	-0.6	-0.4
Loneliness, isolation	0.6	0.8	2.3	0.7	-0.0	-0.4	-1.5	-1.3	-0.6
Long-standing illness, disability or infirmity	1.7	2.6	5.9	2.4	2.0	-0.1	1.8	-1.5	0.3
Ever had bowel cancer screening	1.6	1.8	4.5	-0.3	1.5	1.3	1.3	-2.1	0.8
Diabetes diagnosed by doctor	1.9	3.1	8.8	1.4	3.0	1.8	1.4	-1.4	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	-0.2	0.0	-0.1	-0.1	-0.6	-0.6
Friendships satisfaction	1.2	1.5	3.0	1.7	1.1	-1.3	1.6	0.5	0.5
Qualifications: nursing, teaching	0.8	1.2	2.8	-0.8	-0.3	1.1	0.0	1.7	1.6
Commuting to job workplace: Walk	2.3	2.5	7.2	2.7	2.2	-0.2	1.6	-0.3	0.8
Eye problems/disorders: Cataract	0.2	0.3	0.9	0.3	0.5	0.4	1.0	0.5	0.2
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	7.7	2.8	2.0	-1.0	1.3	-1.1	0.2
Medication for cholesterol	1.6	2.5	5.7	-2.4	-2.0	1.1	-1.8	1.0	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.4	5.1	13.2	3.6	2.3	-0.7	2.9	-1.7	0.8
Back pain experienced in last month	1.1	1.6	3.7	1.9	1.7	-0.6	1.0	-1.3	-0.2
Mineral and other dietary supplements	1.2	1.7	5.7	2.4	0.8	-1.6	0.7	-0.7	-0.2
Breast cancer (self-reported)	1.6	1.9	5.0	1.2	1.3	-0.5	2.2	0.7	1.5
Asthma (self-reported)	0.2	0.4	1.5	-0.5	0.7	1.2	0.0	-0.1	0.6
Osteoporosis (self-reported)	0.3	0.4	1.7	0.2	0.1	-0.6	-0.4	1.3	-0.6
Osteoarthritis (self-reported)	0.7	0.8	1.9	1.0	0.5	-1.2	0.5	-1.4	-0.5
Medication: Aspirin	0.6	0.8	2.2	0.8	1.1	-0.7	1.5	-0.2	-0.2
Medication: Gliclazide	0.1	0.1	0.3	0.0	-0.0	0.2	0.3	-0.5	-0.1
Illnesses of father: None of the above (group 1)	1.7	2.1	4.3	-2.1	-1.0	1.4	-1.2	2.0	-0.4
Smoking status: Current	0.2	0.4	1.3	-0.5	-1.2	-0.5	-0.5	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	5.6	-2.2	-1.6	1.3	0.1	2.4	1.6
Whole body water mass	0.2	1.3	2.6	0.2	1.6	1.3	1.0	-0.4	1.6
Leg predicted mass (right)	0.1	0.5	1.2	0.2	1.1	0.5	0.6	-0.5	1.0
Arm fat mass (left)	1.1	4.5	13.2	1.9	2.9	0.4	1.2	-3.6	0.6
Number of self-reported non-cancer illnesses	1.1	2.0	4.8	1.5	2.2	0.1	0.8	-2.0	-0.3
Average weekly champagne plus white wine intake	2.7	3.8	9.1	1.7	3.0	1.5	2.3	-1.0	1.4
Miserableness	1.0	1.7	6.9	1.2	-0.3	-1.3	-0.3	-2.6	-0.5
Guilty feelings	0.2	0.3	0.8	-0.2	-0.5	0.0	-0.4	-0.9	-0.6
Wears glasses or contact lenses	0.9	1.1	3.1	0.5	1.8	1.2	1.2	-0.2	0.5
Ever taken oral contraceptive pill	0.8	0.8	2.2	-1.5	-0.6	0.5	-0.3	1.5	0.0
Hearing aid user	0.2	0.3	0.9	0.3	0.1	-0.1	-0.7	-1.0	0.1
Mother’s age at death	0.5	0.6	1.7	-0.2	-0.3	1.1	0.3	1.3	0.8
Financial situation satisfaction	0.2	0.3	0.9	0.7	1.0	-0.3	0.2	-0.5	-0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	1.3	-0.1	-1.4	0.1	-0.4	0.1
Commuting to job workplace: Public transport	1.3	1.6	4.1	1.9	-0.0	-2.0	-0.2	-1.3	0.1
Eye problems/disorders: Glaucoma	0.7	0.8	2.1	0.3	0.8	1.1	0.9	0.1	1.4
Medication: Blood pressure	0.6	1.1	3.4	1.8	0.8	-1.0	1.2	-0.1	0.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.4	1.9	0.7	-1.2	0.2	-0.2	-0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.1	-1.8	-1.1	0.9	-0.8	-0.5	-0.1
High cholesterol (Self-reported)	0.5	0.9	2.0	1.3	1.4	-0.1	0.7	-1.0	-0.5
Medication: Bendroflumethiazide	0.5	0.7	1.8	1.2	0.0	-1.3	0.5	-0.8	-0.4
Medication: Paracetamol	0.3	0.5	1.1	0.1	-0.9	-1.0	-0.4	0.4	-1.1
Medication: Lisinopril	0.6	0.7	1.8	0.1	0.6	-1.0	-0.9	-0.7	-1.4
Medication: Atorvastatin	2.6	3.2	6.0	1.9	2.4	0.9	2.2	-0.5	1.8
Illnesses of father: High blood pressure	0.2	0.2	0.4	0.2	-0.3	-0.7	-0.4	0.6	0.2
Alcohol drinker status: Never	1.9	2.3	5.0	2.1	1.0	-1.7	0.7	-2.2	-0.3
Ever smoked	0.4	0.6	1.7	0.1	-0.8	-0.8	-0.4	-0.8	-1.3
Basal metabolic rate	0.3	1.8	4.4	0.8	2.1	1.1	1.2	-1.2	1.3
Leg fat percentage (left)	1.8	6.6	15.9	2.4	3.7	0.7	1.7	-4.0	0.6
Arm fat-free mass (left)	0.3	1.4	2.7	0.2	1.6	1.2	0.8	-1.4	1.3
Number of operations (self-reported)	0.2	0.3	1.3	0.3	0.6	0.4	-0.2	-1.1	-0.3
Average weekly beer plus cider intake	1.7	2.4	5.4	-1.3	-2.3	-0.9	-1.3	1.4	-1.7
Irritability	0.3	0.6	1.8	-1.1	-1.4	-0.2	-0.6	-0.1	0.2
Risk taking	3.0	4.4	8.8	-3.0	-2.5	0.7	-2.3	1.2	-1.9
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.2	1.1	1.8	0.0	1.5	-1.8	1.1
Fractured/broken bones in last 5 years	0.1	0.1	0.5	0.4	0.5	-0.0	-0.1	0.7	-0.2
Age started oral contraceptive pill	1.0	1.3	3.8	-0.5	-1.4	-1.2	0.2	2.0	-0.2
Diastolic blood pressure, automated reading	0.2	0.6	3.5	0.3	0.2	0.4	-0.2	-1.9	-0.0
Ever depressed for a whole week	2.2	2.7	6.6	0.0	-1.4	-1.3	-2.6	-1.0	-2.2
Unable to work because of sickness or disability	0.9	1.2	5.8	0.8	0.6	0.3	-0.5	-2.4	0.1
Commuting to job workplace: Cycle	0.5	0.6	2.1	0.4	0.9	-0.1	-0.2	-1.5	-0.5
Myopia	0.5	0.7	1.6	-0.1	-0.3	-1.0	-0.4	-1.3	-1.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.7	-1.6	-1.0	0.5	-0.3	1.6	0.2
Cholesterol lowering medication	2.1	3.1	9.4	3.1	2.1	-1.5	0.4	-1.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	6.4	1.3	2.5	1.0	1.2	-2.1	1.2
Pain experienced in last month	0.6	1.1	2.7	-1.6	-1.7	0.3	-1.0	0.2	-0.3
Supplements: Calcium	0.8	0.9	3.7	-1.9	-0.9	0.6	-0.3	-0.7	0.2
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-0.8	-0.5	0.5	-1.0	-0.6	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.4	0.4	0.1	0.1	-0.7	-1.4	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.4	1.2	0.0	-0.4	-0.4	-0.2	0.9
Heart disease (siblings)	1.2	1.5	3.4	0.9	1.6	0.9	1.9	0.5	1.0
Alcohol drinker status: Previous	0.5	0.6	2.2	1.5	0.8	-0.7	0.4	0.2	0.1
Pack years of smoking	0.4	0.6	1.9	-0.1	1.4	1.0	-0.0	-0.7	-0.1
Impedance of whole body	0.7	3.6	8.4	2.9	-0.4	-2.8	0.2	1.4	-1.7
Leg fat mass (left)	1.6	6.1	16.3	2.2	3.5	0.8	1.4	-4.0	0.8
Arm predicted mass (left)	0.3	1.6	3.1	0.2	1.8	1.2	1.1	-1.2	1.4