Hub : Genes

UTP20

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2363	0.0721	0.00180	0.081	NA	0.061	NA	0.129	7.4e-04	NA	3.2e-03	NA	2.2e-05
2	GTEx	Testis	0.3390	0.0890	0.00120	-0.006	NA	0.056	NA	0.000	8.8e-01	NA	1.8e-03	NA	3.1e-01
3	TCGA	Brain Lower Grade Glioma	0.0747	0.0391	0.00001	0.043	0.044	0.036	NA	0.039	1.1e-05	8.5e-06	5.3e-05	NA	2.9e-05
4	TCGA	Lung Squamous Cell Carcinoma	0.0451	0.0266	0.00130	0.001	0.025	0.015	NA	0.006	2.1e-01	6.4e-04	6.9e-03	NA	5.9e-02
5	TCGA	Prostate Adenocarcinoma	0.0340	0.0189	0.00680	0.006	0.018	0.012	NA	0.010	6.4e-02	4.6e-03	1.7e-02	NA	2.7e-02
6	TCGA	Thyroid Carcinoma	0.0600	0.0330	0.00110	0.033	0.033	0.022	NA	0.022	3.2e-04	3.6e-04	2.8e-03	NA	2.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	1.0	5.3	2.3	-0.2	-0.5	-0.2	-0.0	0.5
Bipolar Disorder or Schizophrenia	0.3	0.8	4.3	2.1	-0.1	0.2	0.2	0.2	-0.5
Depressed Affect (Nagel 2018)	0.9	1.9	4.3	-2.1	-1.3	-1.2	-1.2	-1.0	-1.3
Depression (Nagel 2018)	1.0	1.5	6.0	-0.2	0.1	0.7	-0.8	-1.4	-2.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.6	1.9	0.1	-0.9	-1.0	-1.1	-0.4
Neuroticism (Nagel 2018)	0.6	1.4	4.4	-1.2	-2.1	-1.1	-0.9	-0.5	-0.4
Schizophrenia (2018)	0.2	0.5	1.1	0.8	-0.2	0.7	0.6	0.3	-1.1
Schizophrenia vs Biploar Disorder	2.3	3.1	7.7	-0.2	-0.1	2.8	2.4	2.2	-0.1
Worry (Nagel 2018)	0.8	1.7	2.6	-1.5	-1.3	-1.6	-1.2	-1.4	-0.3
Alzheimer’s Disease (in mother)	1.0	1.2	3.8	2.0	0.5	-0.3	-0.6	-1.6	0.0
Alzheimer’s Disease (in father)	2.3	2.5	5.5	0.8	-1.5	-2.3	-2.3	-1.3	-0.0
Alzheimer’s Disease (including proxy)	1.2	1.7	5.4	2.3	-0.3	-1.3	-1.1	-1.2	0.8
Crohns Disease (2017)	0.1	0.2	0.5	-0.5	-0.0	0.4	0.0	-0.7	-0.6
Irritable Bowel Disease (IBD)	0.3	0.8	1.8	-0.4	-0.4	-1.3	-0.9	-0.1	1.3
Ulcerative Colitis (UC)	1.0	1.9	7.2	0.1	-0.6	-1.5	-0.8	0.9	2.7
Major Depression (MDD)	0.6	0.7	1.4	-0.9	0.7	-0.6	-1.2	-0.0	-1.1
Reaction Time	0.3	0.6	1.5	0.8	-0.7	-0.4	-0.8	-1.2	-0.5
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.6	1.9	0.7	-0.8	-1.5	-2.2	-1.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.3	1.7	4.8	2.2	-1.2	-1.2	-0.1	-1.6	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.1	1.6	3.1	0.0	1.1	-0.4	-1.7	-1.6	-1.8
Bipolar Disorder (2011)	1.6	1.6	8.6	2.9	0.1	0.2	0.3	0.3	0.7
Body Mass Index (BMI) (2010)	0.8	1.1	2.4	-1.6	-0.7	0.6	0.9	1.5	0.2
Coronary Artery Disease (CAD)	0.4	0.5	1.9	0.3	-0.2	-1.4	-0.9	-0.2	0.4
Crohns Disease (2012)	0.2	0.3	1.0	0.3	0.2	1.0	0.6	0.4	-0.3
Mean Putamen Volume	0.6	0.7	1.7	-0.1	1.3	1.1	0.8	0.7	0.4
Fasting Glucose	0.7	0.9	2.9	0.1	-1.0	1.7	1.1	0.5	-0.2
HbA1C	0.6	0.6	2.2	-0.0	0.5	0.1	1.0	1.5	0.6
HDL Cholesterol	0.4	0.6	2.0	-0.8	1.4	-0.6	-0.8	-0.3	-0.1
LDL Cholesterol	0.4	0.7	3.0	0.2	1.7	0.2	0.0	1.0	0.1
Lupus	1.4	2.1	11.6	-0.1	-0.5	-0.1	0.1	0.9	3.4
Neuroticism (2016)	0.4	0.6	2.3	-1.1	-0.1	-0.3	0.1	-0.2	-1.5
Primary Biliary Cirrhosis	1.6	2.3	3.5	1.8	-1.3	-1.4	-1.9	-1.6	-1.0
Rheumatoid Arthritis	0.7	1.0	3.2	0.4	-1.2	-1.8	-0.6	0.4	0.6
Schizophrenia (2014)	0.4	1.0	2.9	1.0	-0.1	1.7	1.0	0.6	-0.7
Triglycerides	0.9	1.5	3.3	0.4	-0.9	0.5	1.7	1.8	1.2
Type 2 Diabetes (T2D) (2012)	1.5	1.8	7.0	2.6	1.2	0.7	0.7	0.1	-1.2
Ulcerative Colitis	0.7	1.0	3.4	0.5	0.3	-1.9	-1.2	-0.4	0.8
Blood Eosinophil Count	0.3	2.4	4.9	-0.1	-1.2	-2.2	-1.9	-0.5	-2.1
Blood Platelet Count	0.0	0.4	0.9	0.4	-0.8	-0.5	0.3	0.9	-0.4
Blood Red Count	0.1	1.2	4.7	-2.2	1.5	0.6	0.1	-0.2	-0.0
Blood White Count	0.2	1.4	3.4	-1.2	1.8	-1.3	-1.1	-0.4	-0.9
Heel T-Score	0.2	2.0	4.0	0.6	-0.2	-1.9	-2.0	-1.3	-1.4
BMI	0.5	2.7	5.5	1.1	-2.3	-2.4	-1.6	-1.2	-0.1
Height	0.4	7.0	26.5	-5.1	-1.9	2.4	1.9	1.5	0.5
Waist Hip Ratio (WHR)	0.1	0.5	1.1	-1.0	1.0	-0.5	-0.7	0.0	0.4
Systolic Blood Pressure	0.0	0.2	0.6	0.6	0.8	0.7	0.3	0.1	-0.0
Smoking Status	0.3	0.8	1.4	-1.2	0.9	-0.7	-1.0	-0.9	-0.7
Allergy or Eczema	0.5	1.2	3.1	0.2	-0.1	1.8	0.8	0.7	-1.8
Cardiovascular Disease	0.5	1.7	3.9	1.0	-0.2	-1.3	-1.6	-2.0	-1.1
Hypothyroidism (self reported)	0.2	0.4	1.5	1.2	0.0	0.5	0.2	0.6	-0.5
Respiratory disease	0.2	0.4	1.0	-0.7	-0.3	0.2	0.5	1.0	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.2	-0.1	1.5	-0.4	-0.8	-0.6	-0.3
Lung FEV1/FVC ratio	0.2	0.9	4.8	-0.4	2.2	0.2	-0.4	0.1	0.3
Lung FVC	0.1	0.5	1.4	-0.2	0.5	1.2	0.7	-0.7	-0.2
Neuroticism	1.5	3.5	7.5	-2.7	-2.2	-1.6	-1.6	-1.8	-0.9
Chronotype (morning person)	0.2	0.5	2.1	-0.5	-0.3	0.4	0.0	-0.4	-1.5
Hair Pigment	0.0	0.3	0.8	0.2	0.4	0.8	0.2	-0.9	0.1
Tanning	0.0	0.3	0.7	-0.5	0.0	-0.9	-0.4	-0.6	0.7
Hand grip strength (left)	0.9	2.3	4.7	-0.9	-1.5	0.6	1.7	1.8	2.2
Number of treatments/medications taken	0.2	0.3	1.4	-0.5	-1.2	0.1	-0.2	0.5	0.4
Average weekly spirits intake	1.3	1.6	3.7	-1.9	0.0	0.1	-0.7	-1.9	-1.4
Sensitivity / hurt feelings	1.5	2.5	9.2	-0.6	-3.0	-0.4	0.7	1.5	1.7
Frequency of depressed mood in last 2 weeks	1.2	1.7	6.0	-0.6	0.6	-0.2	-1.2	-1.4	-2.4
Hearing difficulty/problems: Yes	1.0	1.5	3.5	0.2	-0.1	-1.5	-1.7	-1.9	-0.6
Relative age of first facial hair	0.5	1.0	3.4	0.9	1.8	1.1	0.6	0.0	-0.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.3	0.6	1.3	1.0	1.5	1.1	0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.8	-0.7	0.0	0.2	-0.1	-0.3	0.9
Ever had hysterectomy (womb removed)	1.3	1.4	3.3	0.2	0.5	0.8	1.2	1.8	1.7
Systolic blood pressure, automated reading	0.2	0.6	1.2	-0.8	0.5	1.1	0.8	-0.4	-0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.1	-0.1	1.8	0.9	-0.4	-1.1	-0.4
Angina	0.5	0.6	1.3	-1.0	1.0	0.0	0.6	1.1	0.2
Medication for hormone replacement therapy	0.9	1.0	2.5	0.6	-1.2	-0.4	-1.0	-0.9	-1.6
Vitamin and mineral supplements	2.5	3.4	7.1	-0.6	2.2	-0.7	-1.8	-2.1	-2.7
Supplements: Zinc	0.8	0.9	2.1	-1.4	-1.1	0.3	0.4	0.1	1.3
Medication: Co-codamol	0.6	0.7	2.1	-0.8	0.0	0.9	1.5	0.7	-0.2
Medication: Metformin	0.2	0.3	0.8	0.1	0.9	-0.5	-0.6	-0.7	-0.3
Diabetes (father)	1.1	1.3	4.3	1.4	-2.1	-1.1	-0.7	-0.1	-0.1
Diabetes (mother)	0.8	1.0	2.6	-0.4	0.8	-1.6	-1.4	-0.7	-0.0
Severe depression (siblings)	0.2	0.2	0.7	0.8	0.1	0.5	0.2	-0.1	-0.5
Pack years adult smoking proportion	0.8	1.2	4.8	-0.6	2.2	0.5	0.4	0.8	-0.9
Impedance of leg (right)	0.1	0.4	1.0	-0.4	-0.5	1.0	0.1	0.3	-0.9
Leg fat-free mass (left)	0.3	1.3	2.8	-1.4	-1.7	0.3	1.1	1.1	0.9
Trunk fat percentage	0.1	0.4	1.0	-0.6	-0.4	-1.0	-0.7	-0.2	-0.5
Hand grip strength (right)	0.1	0.4	1.0	-0.3	-1.0	0.6	0.7	0.4	0.1
Townsend deprivation index at recruitment	1.0	1.5	2.1	-1.4	1.2	1.5	1.0	0.8	1.3
Current tobacco smoking	0.5	0.9	2.1	-1.5	0.8	-0.5	-0.6	0.9	1.0
Average weekly fortified wine intake	1.1	1.3	7.0	2.6	-0.1	0.5	0.0	0.5	-0.2
Maternal smoking around birth	1.6	2.3	9.3	0.1	0.3	-3.0	-2.1	0.2	0.4
Fed-up feelings	1.0	1.8	3.2	-1.8	-1.2	-1.3	-1.6	-1.2	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.7	0.7	0.7	0.7	0.2	-0.3	-1.3
Relative age voice broke	0.4	0.6	1.3	1.2	0.4	0.8	0.7	0.6	0.7
Taking other prescription medications	0.7	1.1	2.8	1.7	1.1	1.2	0.2	0.2	-1.0
Age when periods started (menarche)	0.2	0.4	1.3	0.6	0.2	-0.4	-0.6	-1.1	-0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.4	0.3	1.0	0.2	0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.1	-0.2	0.7	0.2	-0.2	-0.4	-1.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	4.9	-2.2	1.5	0.3	-0.6	-0.9	-0.6
Qualifications: CSEs or equivalent	0.6	0.8	2.4	-1.0	0.0	0.5	-0.3	-1.1	-1.5
Serious illness, injury or assault to yourself	0.3	0.4	1.3	0.3	-0.6	-0.5	-0.3	0.3	1.1
High blood pressure	0.6	1.6	4.2	0.4	0.3	-1.7	-2.0	-1.4	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.8	0.6	0.2	1.3	0.3	-0.1	-1.2
Multivitamins +/- minerals	0.4	0.6	1.5	0.2	-1.2	0.0	0.8	0.6	0.9
Stomach or abdominal pain in last month	1.0	1.3	3.8	0.1	-0.1	-1.9	-0.5	0.9	1.6
Supplements: Glucosamine	1.4	1.8	4.0	-1.5	-1.5	0.2	1.2	2.0	0.7
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.9	0.6	0.3	-1.1	-0.9	0.1	1.7
Medication: Atenolol	0.7	0.8	2.7	-1.6	-0.4	-1.1	-0.3	0.0	0.9
Medication: Levothyroxine sodium	0.5	0.9	2.8	1.2	1.7	0.6	-0.2	0.8	0.3
Sitting height	0.6	4.1	12.3	-3.5	-1.8	1.6	1.7	1.4	1.2
Chronic bronchitis/emphysema (father)	1.3	1.6	3.1	0.1	1.4	1.8	1.7	1.2	0.2
High blood pressure (mother)	0.2	0.2	0.8	0.3	-0.2	-0.6	-0.1	-0.4	-0.9
Body mass index (BMI)	0.1	0.5	1.8	0.1	0.0	-1.4	-0.9	-0.6	-0.6
Impedance of leg (left)	0.1	0.3	0.9	0.1	-0.2	1.0	0.0	-0.3	-0.8
Leg predicted mass (left)	0.2	1.3	2.6	-1.4	-1.6	0.3	1.1	1.1	0.8
Trunk fat mass	0.1	0.4	1.2	-1.1	-0.7	-0.7	-0.3	0.1	-0.3
Waist circumference	0.1	0.2	0.4	-0.6	-0.6	-0.6	-0.3	0.4	0.0
Number of incorrect matches in round	0.3	0.4	0.7	0.5	-0.8	0.8	0.8	0.6	0.2
Past tobacco smoking	0.1	0.2	1.2	0.1	0.0	-0.1	-0.0	-0.0	1.1
Alcohol usually taken with meals	0.8	1.2	4.5	0.3	-2.1	-1.3	-1.0	-0.3	0.1
Nervous feelings	1.2	2.1	8.1	0.1	-2.9	-1.7	-1.2	-0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.2	-0.1	-0.2	-0.8	-1.4	-1.2	-2.0
Hearing difficulty/problems with background noise	0.4	0.7	1.5	-0.7	-0.0	-0.6	-1.0	-1.2	-0.8
Hair/balding pattern: Pattern 2	0.7	0.8	3.2	-1.1	1.8	0.7	0.1	0.1	0.1
Had menopause	0.1	0.1	0.2	-0.3	0.5	-0.2	0.1	0.4	-0.0
Had other major operations	0.2	0.2	0.5	0.2	0.7	-0.4	-0.1	0.2	0.7
Forced vital capacity (FVC)	0.9	3.4	8.6	-0.5	-1.4	2.9	2.5	1.1	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.2	-0.2	-0.6	-0.8	-0.5	-0.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.3	-0.2	-1.0	-1.5	-0.9	-1.5	1.0
Qualifications: None of the above	0.7	1.5	3.4	-1.9	1.0	-1.2	-0.8	1.1	1.3
Financial difficulties in last 2 years	0.9	1.2	5.9	-2.4	0.5	-0.7	0.1	0.6	0.7
Mouth/teeth dental problems	0.6	1.0	1.4	0.5	-0.9	1.2	1.1	1.1	1.0
Heart attack	0.5	0.6	1.5	-1.0	0.3	-0.1	0.7	0.8	1.2
Allergy	0.4	1.0	3.0	-1.1	-0.5	-1.7	-0.9	-0.7	0.6
Pain all over the body in last month	1.7	1.8	5.3	-0.8	1.2	2.3	1.7	0.7	-0.2
Diabetes (self-reported)	0.7	1.1	2.1	0.4	1.2	-1.2	-1.5	-1.0	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.8	-0.2	0.8	0.2	-0.0	-0.7
Medication: Ramipril	0.7	0.9	2.0	0.8	1.4	-0.8	-1.0	-0.9	-0.5
Medication: Simvastatin	1.0	1.5	3.1	-0.0	1.8	-0.8	-1.6	-1.1	-1.2
Fluid intelligence score	0.7	1.5	3.2	1.8	-0.0	-1.4	-1.2	-1.2	-0.8
Illnesses of siblings	1.5	2.1	10.4	0.4	3.2	1.1	0.1	0.3	0.5
Neuroticism score	1.0	2.2	6.4	-2.5	-1.4	-1.5	-1.2	-0.7	-0.6
Weight	0.1	0.6	2.1	-1.5	-1.1	-0.3	0.2	0.3	-0.1
Impedance of arm (right)	0.1	0.2	0.5	0.7	0.0	0.5	0.2	0.6	0.4
Arm fat percentage (right)	0.1	0.3	1.4	0.2	-0.4	-1.2	-0.6	0.1	-0.4
Trunk fat-free mass	0.4	2.2	4.3	-2.1	-1.8	1.1	1.6	1.3	0.6
Hip circumference	0.1	0.4	1.8	-0.6	-1.3	-0.5	-0.0	0.2	-0.2
Time employed in main current job	2.1	2.4	6.7	0.9	-0.2	-1.1	-1.7	-1.7	-2.6
Alcohol intake versus 10 years previously	1.2	1.7	6.2	0.2	-0.1	-1.1	0.4	1.7	2.5
Father’s age at death	1.1	1.5	4.4	0.1	1.9	2.1	0.7	0.0	0.6
Worrier / anxious feelings	1.0	1.8	3.3	-1.8	-1.8	-1.5	-1.1	-1.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	-1.0	0.3	-0.6	-0.9	-0.6	-0.5
Falls in the last year	0.8	1.1	2.0	1.1	0.8	-1.4	-1.4	-0.8	-0.6
Hair/balding pattern: Pattern 3	1.7	2.5	5.0	1.2	0.0	2.2	2.2	1.8	0.8
Number of live births	0.2	0.3	1.6	1.3	-0.2	-0.4	-0.1	0.4	0.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	6.7	-0.3	-0.6	2.6	2.2	0.8	1.1
Pulse rate	0.3	0.4	1.5	1.2	0.7	0.2	0.2	0.1	0.7
Happiness	0.1	0.1	0.2	-0.1	0.5	-0.2	0.2	-0.4	-0.2
Noisy workplace	0.1	0.1	0.2	0.5	-0.4	0.1	0.1	-0.0	-0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.6	1.3	0.8	-0.9	-1.3	-1.9	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.6	0.6	0.0	-0.1	0.1	0.8	1.3
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	-0.8	0.2	-1.1	-0.6	-0.1	0.5
Asthma	0.5	1.1	2.7	-0.1	0.8	1.6	1.3	0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.9	-2.0	-1.7	-0.2	0.4	0.9	1.1
Medication: Cholesterol lowering	2.0	3.0	8.8	1.6	0.8	-0.9	-1.8	-1.5	-3.0
Depression (self-reported)	0.1	0.1	0.3	0.5	0.3	-0.4	-0.5	-0.1	0.1
Medication: Lansoprazole	0.4	0.5	1.8	-0.0	-0.9	-0.6	0.3	1.3	0.3
Prospective memory result	0.5	0.6	1.6	-0.1	-0.1	0.1	0.9	1.0	1.3
Lung cancer (father)	0.7	0.8	1.7	-0.8	0.4	-1.3	-0.9	-0.8	1.1
Illnesses of mother	0.5	0.6	1.2	-0.8	0.9	0.8	0.5	1.1	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	9.8	-0.2	-1.2	3.1	2.9	1.4	1.1
Pulse wave Arterial Stiffness index	0.4	0.4	1.1	-0.3	-0.3	-0.7	-0.9	-1.1	0.3
Impedance of arm (left)	0.0	0.1	0.5	0.1	-0.0	0.7	0.1	0.5	-0.0
Arm fat mass (right)	0.0	0.2	0.5	-0.2	-0.7	-0.7	-0.1	0.2	-0.3
Trunk predicted mass	0.4	2.4	4.7	-2.2	-1.8	1.1	1.7	1.4	0.7
Standing height	0.5	4.9	11.6	-3.4	-2.5	2.1	2.1	1.6	0.8
Length of working week for main job	2.0	2.2	3.6	-1.0	-0.3	1.6	1.9	1.6	1.8
Exposure to tobacco smoke at home	0.6	0.6	1.5	0.9	-1.2	-0.3	-0.1	0.3	1.2
Breastfed as a baby	1.0	1.3	2.1	1.4	-1.1	-0.7	-0.4	-1.4	-1.4
Tense / ‘highly strung’	0.8	1.3	3.1	-1.8	-0.7	-1.3	-1.1	-0.3	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.3	-0.8	-1.8	-1.1	-0.3	0.4	1.7
Hair/balding pattern: Pattern 4	1.1	2.6	7.1	-1.3	-0.7	-2.7	-1.9	-1.4	0.6
Birth weight of first child	0.4	0.8	3.8	-0.1	-0.5	-0.1	0.3	0.8	2.0
Peak expiratory flow (PEF)	0.2	0.5	1.1	-0.1	-0.4	1.0	1.0	0.2	0.7
Pulse wave reflection index	0.2	0.2	0.6	0.0	0.8	0.7	0.1	-0.5	-0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.8	0.1	-0.3	0.1	0.3	0.8
Loud music exposure frequency	1.6	1.8	3.6	-0.9	1.0	-1.2	-1.8	-1.9	-0.6
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.7	1.9	0.5	0.7	0.4	0.1	-1.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	2.3	-1.0	1.3	-0.7	-1.2	-1.4	-1.5
Blood clot in the leg (DVT)	0.6	0.7	2.3	1.5	0.2	0.5	0.5	1.1	0.6
Medication: Paracetamol	1.3	2.2	8.1	0.6	-2.8	0.1	1.3	1.1	1.3
Headache pain in last month	0.4	0.6	2.3	0.0	-1.5	-0.2	0.0	0.7	-0.9
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	5.0	-1.0	-0.8	0.3	1.2	1.1	2.2
Glaucoma (self-reported)	0.3	0.4	0.8	0.1	0.9	-0.8	-0.9	0.0	-0.1
Gout (self-reported)	2.3	3.1	6.5	0.2	2.2	-1.2	-2.2	-2.5	-1.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	3.0	1.7	0.9	0.5	-0.4	0.2	-0.4
Medication: Amlodipine	0.5	0.6	1.7	1.3	1.1	-0.0	-0.5	-0.7	-0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.4	-0.9	1.5	0.1	-0.0	-0.1	-0.6
Birth weight	0.5	1.1	3.6	-0.4	-1.9	-1.1	-0.2	-0.3	1.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.2	-1.1	-0.6	0.5	0.8	0.6	-0.1
High blood pressure (siblings)	0.7	1.0	4.6	-0.9	-2.1	0.1	0.7	-0.1	-0.5
Forced vital capacity (FVC), Best measure	1.2	4.2	9.9	-0.5	-1.8	3.1	2.9	1.3	1.3
Body fat percentage	0.1	0.5	1.3	-0.5	-0.6	-1.1	-0.8	-0.1	-0.6
Leg fat percentage (right)	0.2	0.7	1.4	-0.6	-0.6	-1.2	-1.1	-0.3	-1.0
Arm fat-free mass (right)	0.4	1.8	4.5	-2.1	-1.5	1.0	1.4	1.0	0.3
Exposure to tobacco smoke outside home	0.6	0.9	3.0	-1.7	1.1	-0.1	-0.4	0.6	0.7
Comparative body size at age 10	0.3	0.8	2.5	0.6	0.3	-1.6	-0.7	0.4	1.0
Number of full brothers	0.4	0.5	1.4	-0.7	-0.1	-1.1	-1.2	-0.0	-0.4
Worry too long after embarrassment	0.4	0.7	1.6	-1.3	-1.1	0.6	0.1	1.0	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	5.8	-2.4	-0.2	-0.5	-0.4	-0.2	1.1
Wheeze or whistling in the chest in last year	0.2	0.4	1.3	-0.2	0.5	0.0	0.0	1.2	-0.8
Number of children fathered	1.2	1.3	4.8	0.0	0.2	0.9	1.3	2.2	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.3	1.5	-1.0	1.2	1.3	1.1	0.3
Age at first live birth	2.3	4.0	8.4	1.1	0.6	-1.2	-2.5	-2.9	-2.5
Pulse wave peak to peak time	0.4	0.4	1.2	-0.2	-0.1	0.7	0.8	1.1	-0.4
Health satisfaction	0.2	0.2	0.9	-0.1	-0.3	-0.1	-0.4	-0.4	-1.0
Shortness of breath walking on level ground	1.7	2.1	4.4	0.3	1.7	-1.0	-1.5	-2.1	-1.3
Qualifications: College or University degree	0.3	0.9	3.1	1.2	-1.8	0.2	0.3	-0.2	0.9
Eye problems/disorders: None of the above	0.1	0.1	0.4	-0.3	-0.4	-0.7	-0.0	0.4	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.2	-0.3	-0.0	0.1	-0.2	-0.3	-1.1
Emphysema/chronic bronchitis	0.3	0.4	1.4	0.6	0.1	-1.2	-0.7	0.2	0.0
Medication for pain relief, constipation, heartburn	0.8	1.3	4.3	0.7	2.1	-0.0	-1.1	-1.1	-0.8
Neck or shoulder pain in last month	0.6	0.8	3.3	-1.8	-0.5	0.6	0.3	0.9	-0.3
Medication: Blood pressure	1.3	2.3	5.1	1.1	0.4	-1.7	-2.2	-1.5	-1.5
Angina (self-reported)	0.4	0.5	1.8	-1.4	1.0	-0.3	0.2	0.6	-0.0
Migraine (self-reported)	0.3	0.3	1.1	-0.2	1.0	-0.6	-0.2	0.6	0.1
Medication: Ibuprofen	1.3	1.6	4.1	-2.0	-1.5	-0.2	0.5	1.3	1.0
Medication: Allopurinol	1.2	1.6	3.3	-0.3	1.8	-1.2	-1.5	-1.5	-0.6
Medication: Omeprazole	0.3	0.3	1.3	1.1	-0.1	-0.1	0.2	0.6	0.5
Medication: Seretide 50 evohaler	0.5	0.5	1.1	1.0	-1.0	0.8	0.8	0.0	-0.2
Mean time to correctly identify matches	0.5	1.0	1.5	0.9	-0.8	-1.2	-1.1	-1.2	-0.8
Heart disease (mother)	0.8	1.0	2.3	1.4	-1.5	-0.3	0.9	0.8	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.1	0.1	-1.1	-0.0	-0.3	0.1	-1.0
Whole body fat mass	0.1	0.3	0.6	-0.8	-0.7	-0.7	-0.2	0.2	-0.3
Leg fat mass (right)	0.1	0.3	0.9	-0.6	-0.9	-0.7	-0.3	0.0	-0.4
Arm predicted mass (right)	0.3	1.7	6.0	-2.4	-1.0	0.9	1.3	0.8	0.1
Pulse rate, automated reading	0.1	0.4	1.8	0.5	1.3	0.3	-0.3	-0.2	0.2
Alcohol intake frequency.	0.4	0.9	3.9	-1.1	2.0	-0.2	0.1	-0.1	0.1
Comparative height size at age 10	0.6	3.1	8.1	-2.7	-2.9	0.6	0.8	1.2	0.8
Number of full sisters	0.5	0.6	2.4	0.1	-0.1	-0.5	0.6	0.7	1.6
Suffer from ‘nerves’	0.7	1.1	2.8	-0.8	0.5	-0.7	-1.3	-1.7	-1.0
Overall health rating	0.6	1.4	3.1	0.2	-0.0	0.9	1.2	1.8	1.7
Chest pain or discomfort	0.2	0.3	1.0	-0.6	1.0	-0.1	0.0	-0.7	0.0
Had major operations	0.7	0.8	2.0	0.6	-0.9	0.7	0.8	0.7	1.4
Age at last live birth	1.6	2.3	5.0	0.4	1.4	-0.5	-1.8	-2.2	-1.8
Family relationship satisfaction	0.3	0.4	1.7	0.1	-0.4	-0.3	0.7	1.3	0.2
Leg pain on walking	0.3	0.4	1.5	0.2	-0.5	1.2	0.7	-0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.4	-1.4	1.8	1.0	0.8	0.6	0.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.1	0.9	-0.0	1.5	0.9	0.1	-0.0
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.9	1.3	0.9	1.4	0.7	-1.0	-1.1
Medication: Aspirin	0.2	0.2	0.4	-0.5	0.3	-0.3	-0.4	-0.6	-0.5
Supplements: Vitamin C	2.0	2.3	4.5	0.3	-1.2	1.4	1.5	1.9	2.1
Knee pain experienced in last month	0.8	1.2	2.9	-0.0	-1.7	-0.1	0.6	1.1	1.7
Hypertension (Self-reported)	0.6	1.6	3.7	0.1	-0.0	-1.5	-1.9	-1.6	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.8	0.0	-0.0	0.4	-0.4	0.3	-1.4
Illnesses of father: Heart disease	0.4	0.6	2.4	0.1	0.2	0.6	0.4	0.5	-1.6
Illnesses of siblings: Diabetes	1.5	1.9	5.6	0.3	-2.4	-1.4	-1.5	-0.8	-1.0
Smoking status: Previous	0.6	1.0	4.3	0.1	-0.2	-0.3	-0.5	-1.0	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	5.6	-0.8	-2.4	1.7	1.4	1.7	0.5
Whole body fat-free mass	0.3	2.0	3.1	-1.8	-1.8	0.9	1.6	1.3	0.8
Leg fat-free mass (right)	0.2	1.2	2.2	-1.2	-1.5	0.3	1.2	0.9	1.1
Arm fat percentage (left)	0.1	0.4	1.1	-0.0	-0.4	-1.0	-0.6	0.0	-0.7
Average weekly red wine intake	0.3	0.4	1.4	1.2	-0.1	-0.3	-0.1	-0.8	0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.5	-0.3	0.1	-0.4	-0.6	-0.7	-1.2
Mood swings	1.0	1.9	5.2	-2.3	-1.6	-1.6	-0.8	-0.4	0.7
Loneliness, isolation	1.0	1.3	2.5	-1.6	-0.2	-1.4	-1.6	-0.6	-0.8
Long-standing illness, disability or infirmity	0.4	0.5	1.6	-0.3	0.5	-0.5	0.3	1.0	1.2
Ever had bowel cancer screening	1.0	1.1	3.4	1.0	-0.3	0.2	0.8	1.3	1.8
Diabetes diagnosed by doctor	0.3	0.6	1.4	-0.2	1.0	-0.6	-1.2	-0.8	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.6	-0.7	1.2	1.6	1.1	0.9	0.7
Friendships satisfaction	0.1	0.2	0.8	0.4	-0.3	-0.1	0.2	-0.9	-0.0
Qualifications: nursing, teaching	0.5	0.8	1.6	1.1	-0.6	-0.1	-0.6	-1.1	-1.3
Commuting to job workplace: Walk	0.8	0.9	2.4	-1.4	-0.6	0.8	-0.0	-0.6	-1.6
Eye problems/disorders: Cataract	0.5	0.6	2.4	0.5	-1.5	-0.5	-0.2	-0.5	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.4	-0.2	0.4	0.1	-0.3	-1.0	-1.2
Medication for cholesterol	3.7	5.6	14.2	-0.8	0.1	2.0	3.0	3.8	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	5.8	-0.6	-0.5	1.2	2.3	2.4	0.7
Back pain experienced in last month	1.1	1.6	2.8	-1.1	0.7	1.2	1.7	1.6	1.0
Mineral and other dietary supplements	1.8	2.4	7.5	-0.9	2.7	-0.1	-1.1	-1.1	-2.0
Breast cancer (self-reported)	0.3	0.3	0.6	-0.1	0.5	0.8	0.6	0.7	0.6
Asthma (self-reported)	0.7	1.4	4.0	-0.0	0.7	2.0	1.6	1.0	-0.6
Osteoporosis (self-reported)	0.2	0.3	0.6	0.7	0.8	0.3	-0.1	-0.1	-0.7
Osteoarthritis (self-reported)	0.4	0.5	0.9	0.9	0.5	-0.2	0.5	0.8	0.9
Medication: Aspirin	0.2	0.3	0.8	0.1	0.4	-0.4	-0.6	-0.9	-0.6
Medication: Gliclazide	0.4	0.4	1.1	-0.0	-0.7	-0.4	-0.9	-1.0	0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	2.2	-0.9	0.0	0.1	0.4	-0.5	1.5
Smoking status: Current	0.6	0.9	2.1	-1.2	0.5	-0.2	-0.1	1.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.1	0.7	-1.6	1.6	1.8	0.4	1.3
Whole body water mass	0.3	1.9	3.8	-1.9	-1.7	0.8	1.5	1.3	0.7
Leg predicted mass (right)	0.2	1.2	2.4	-1.2	-1.5	0.3	1.1	0.9	1.1
Arm fat mass (left)	0.1	0.3	0.9	-0.5	-0.7	-0.9	-0.4	0.2	-0.3
Number of self-reported non-cancer illnesses	0.4	0.7	2.6	0.3	1.6	0.9	0.5	0.7	-0.2
Average weekly champagne plus white wine intake	1.0	1.4	3.4	1.8	-0.8	1.4	1.4	0.6	0.5
Miserableness	0.8	1.4	2.7	-1.6	-1.7	-1.4	-0.6	0.2	-0.5
Guilty feelings	0.6	0.9	2.9	-0.2	-1.7	0.0	0.6	1.1	0.8
Wears glasses or contact lenses	1.5	1.7	5.2	-1.3	0.1	0.9	1.0	1.3	2.3
Ever taken oral contraceptive pill	0.5	0.6	1.6	1.0	-1.2	-0.2	-0.1	-0.1	-1.0
Hearing aid user	1.7	1.9	3.2	1.2	1.0	-1.4	-1.8	-1.2	-1.6
Mother’s age at death	1.0	1.2	4.1	-0.3	2.0	0.4	-0.6	-1.2	-1.1
Financial situation satisfaction	0.7	0.9	4.9	-2.2	0.3	-0.3	0.2	0.2	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.6	0.5	-1.0	-1.2	-0.7	0.5	-0.3
Commuting to job workplace: Public transport	0.2	0.2	0.6	-0.2	0.5	0.1	0.5	0.8	0.4
Eye problems/disorders: Glaucoma	0.6	0.7	2.3	-1.3	1.5	0.5	0.1	0.3	-0.2
Medication: Blood pressure	1.1	2.2	6.8	0.3	0.2	-1.3	-1.8	-2.6	-1.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	4.5	-2.1	0.1	-0.6	-0.1	-0.4	1.0
Supplements: Fish oil (including cod liver oil)	1.5	2.0	8.5	1.0	-2.9	-0.0	0.5	-0.0	1.5
High cholesterol (Self-reported)	1.7	3.0	6.3	1.4	0.2	-1.8	-2.5	-2.0	-1.5
Medication: Bendroflumethiazide	0.5	0.8	3.1	1.3	-1.8	0.2	0.2	0.2	0.3
Medication: Paracetamol	0.9	1.4	2.7	0.8	-1.6	0.6	1.4	1.3	1.2
Medication: Lisinopril	2.1	2.8	4.2	1.1	1.8	-0.9	-1.9	-1.9	-2.0
Medication: Atorvastatin	1.1	1.3	5.3	2.3	-0.4	0.1	-0.6	-0.9	-1.1
Illnesses of father: High blood pressure	0.6	0.7	1.8	0.7	0.2	1.3	0.5	0.2	-1.2
Alcohol drinker status: Never	0.9	1.1	2.0	-1.2	0.6	-1.4	-1.2	-0.3	1.1
Ever smoked	0.4	0.7	1.8	-0.7	1.3	-0.0	-0.6	-0.5	-1.1
Basal metabolic rate	0.3	1.7	3.1	-1.8	-1.7	0.7	1.3	1.2	0.6
Leg fat percentage (left)	0.2	0.7	1.3	-0.3	-0.4	-1.1	-1.1	-0.6	-1.0
Arm fat-free mass (left)	0.3	1.8	4.5	-2.1	-1.3	1.0	1.4	1.0	0.4
Number of operations (self-reported)	0.1	0.2	0.7	-0.8	-0.3	0.1	-0.6	-0.2	-0.4
Average weekly beer plus cider intake	0.3	0.4	1.3	-0.5	0.8	-0.4	0.1	1.1	0.1
Irritability	0.1	0.2	0.6	-0.4	-0.8	0.2	-0.2	0.1	-0.8
Risk taking	0.5	0.7	1.5	1.2	0.0	0.8	1.2	0.5	0.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.1	-0.7	0.9	1.8	1.7	1.2	-0.5
Fractured/broken bones in last 5 years	0.9	1.2	2.1	-0.5	0.9	-1.2	-1.3	-1.4	-0.9
Age started oral contraceptive pill	0.1	0.1	0.3	0.5	-0.3	-0.2	0.0	-0.6	-0.0
Diastolic blood pressure, automated reading	0.2	0.7	1.7	-0.6	0.1	1.3	1.3	0.7	0.2
Ever depressed for a whole week	0.6	0.8	1.6	-1.0	-1.0	-0.8	-0.2	-0.7	1.3
Unable to work because of sickness or disability	1.8	2.4	4.6	-2.2	-0.2	0.4	1.1	2.0	2.0
Commuting to job workplace: Cycle	1.8	2.1	8.5	0.0	-1.1	-0.0	0.8	1.6	2.9
Myopia	0.3	0.5	0.7	0.8	-0.7	-0.8	0.0	0.8	0.9
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.4	-0.3	-1.0	1.4	1.5	1.0	0.5
Cholesterol lowering medication	1.7	2.6	5.7	0.1	2.4	-1.0	-1.9	-2.1	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.8	0.6	-0.6	-0.0	0.5	0.6	0.9
Pain experienced in last month	1.2	2.0	5.5	0.7	1.2	-0.5	-1.3	-1.7	-2.3
Supplements: Calcium	0.3	0.3	0.6	0.2	-0.5	0.8	0.7	0.6	0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	-0.2	-1.0	-0.1	0.9	1.0	0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.3	-1.0	0.6	-0.1	0.7	0.8	1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.8	1.3	0.2	0.4	0.5	1.3	0.7
Heart disease (siblings)	0.7	0.9	1.8	1.3	-1.1	-0.6	0.5	1.1	0.9
Alcohol drinker status: Previous	1.0	1.1	4.4	0.2	1.0	-0.2	-0.9	-2.1	-0.7
Pack years of smoking	0.7	1.0	4.0	-0.5	2.0	0.5	0.3	0.3	-1.2
Impedance of whole body	0.0	0.2	0.9	-0.0	0.1	0.9	0.1	0.1	-0.5
Leg fat mass (left)	0.1	0.3	0.7	-0.4	-0.9	-0.5	-0.2	-0.2	-0.5
Arm predicted mass (left)	0.3	1.5	3.7	-1.9	-1.2	0.8	1.4	1.0	0.7