Hub : Genes

UTP20

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.2363 0.0721 0.00180 0.081 NA 0.061 NA 0.129 7.4e-04 NA 3.2e-03 NA 2.2e-05
2 GTEx Testis 0.3390 0.0890 0.00120 -0.006 NA 0.056 NA 0.000 8.8e-01 NA 1.8e-03 NA 3.1e-01
3 TCGA Brain Lower Grade Glioma 0.0747 0.0391 0.00001 0.043 0.044 0.036 NA 0.039 1.1e-05 8.5e-06 5.3e-05 NA 2.9e-05
4 TCGA Lung Squamous Cell Carcinoma 0.0451 0.0266 0.00130 0.001 0.025 0.015 NA 0.006 2.1e-01 6.4e-04 6.9e-03 NA 5.9e-02
5 TCGA Prostate Adenocarcinoma 0.0340 0.0189 0.00680 0.006 0.018 0.012 NA 0.010 6.4e-02 4.6e-03 1.7e-02 NA 2.7e-02
6 TCGA Thyroid Carcinoma 0.0600 0.0330 0.00110 0.033 0.033 0.022 NA 0.022 3.2e-04 3.6e-04 2.8e-03 NA 2.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.6 1.0 5.3 2.3 -0.2 -0.5 -0.2 -0.0 0.5
Bipolar Disorder or Schizophrenia 0.3 0.8 4.3 2.1 -0.1 0.2 0.2 0.2 -0.5
Depressed Affect (Nagel 2018) 0.9 1.9 4.3 -2.1 -1.3 -1.2 -1.2 -1.0 -1.3
Depression (Nagel 2018) 1.0 1.5 6.0 -0.2 0.1 0.7 -0.8 -1.4 -2.5
Intelligence (Savage-Jansen 2018) 0.4 1.1 3.6 1.9 0.1 -0.9 -1.0 -1.1 -0.4
Neuroticism (Nagel 2018) 0.6 1.4 4.4 -1.2 -2.1 -1.1 -0.9 -0.5 -0.4
Schizophrenia (2018) 0.2 0.5 1.1 0.8 -0.2 0.7 0.6 0.3 -1.1
Schizophrenia vs Biploar Disorder 2.3 3.1 7.7 -0.2 -0.1 2.8 2.4 2.2 -0.1
Worry (Nagel 2018) 0.8 1.7 2.6 -1.5 -1.3 -1.6 -1.2 -1.4 -0.3
Alzheimer’s Disease (in mother) 1.0 1.2 3.8 2.0 0.5 -0.3 -0.6 -1.6 0.0
Alzheimer’s Disease (in father) 2.3 2.5 5.5 0.8 -1.5 -2.3 -2.3 -1.3 -0.0
Alzheimer’s Disease (including proxy) 1.2 1.7 5.4 2.3 -0.3 -1.3 -1.1 -1.2 0.8
Crohns Disease (2017) 0.1 0.2 0.5 -0.5 -0.0 0.4 0.0 -0.7 -0.6
Irritable Bowel Disease (IBD) 0.3 0.8 1.8 -0.4 -0.4 -1.3 -0.9 -0.1 1.3
Ulcerative Colitis (UC) 1.0 1.9 7.2 0.1 -0.6 -1.5 -0.8 0.9 2.7
Major Depression (MDD) 0.6 0.7 1.4 -0.9 0.7 -0.6 -1.2 -0.0 -1.1
Reaction Time 0.3 0.6 1.5 0.8 -0.7 -0.4 -0.8 -1.2 -0.5
Verbal and Numeric Reasoning (VNR) 1.0 2.3 4.6 1.9 0.7 -0.8 -1.5 -2.2 -1.5
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.3 1.7 4.8 2.2 -1.2 -1.2 -0.1 -1.6 0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.1 1.6 3.1 0.0 1.1 -0.4 -1.7 -1.6 -1.8
Bipolar Disorder (2011) 1.6 1.6 8.6 2.9 0.1 0.2 0.3 0.3 0.7
Body Mass Index (BMI) (2010) 0.8 1.1 2.4 -1.6 -0.7 0.6 0.9 1.5 0.2
Coronary Artery Disease (CAD) 0.4 0.5 1.9 0.3 -0.2 -1.4 -0.9 -0.2 0.4
Crohns Disease (2012) 0.2 0.3 1.0 0.3 0.2 1.0 0.6 0.4 -0.3
Mean Putamen Volume 0.6 0.7 1.7 -0.1 1.3 1.1 0.8 0.7 0.4
Fasting Glucose 0.7 0.9 2.9 0.1 -1.0 1.7 1.1 0.5 -0.2
HbA1C 0.6 0.6 2.2 -0.0 0.5 0.1 1.0 1.5 0.6
HDL Cholesterol 0.4 0.6 2.0 -0.8 1.4 -0.6 -0.8 -0.3 -0.1
LDL Cholesterol 0.4 0.7 3.0 0.2 1.7 0.2 0.0 1.0 0.1
Lupus 1.4 2.1 11.6 -0.1 -0.5 -0.1 0.1 0.9 3.4
Neuroticism (2016) 0.4 0.6 2.3 -1.1 -0.1 -0.3 0.1 -0.2 -1.5
Primary Biliary Cirrhosis 1.6 2.3 3.5 1.8 -1.3 -1.4 -1.9 -1.6 -1.0
Rheumatoid Arthritis 0.7 1.0 3.2 0.4 -1.2 -1.8 -0.6 0.4 0.6
Schizophrenia (2014) 0.4 1.0 2.9 1.0 -0.1 1.7 1.0 0.6 -0.7
Triglycerides 0.9 1.5 3.3 0.4 -0.9 0.5 1.7 1.8 1.2
Type 2 Diabetes (T2D) (2012) 1.5 1.8 7.0 2.6 1.2 0.7 0.7 0.1 -1.2
Ulcerative Colitis 0.7 1.0 3.4 0.5 0.3 -1.9 -1.2 -0.4 0.8
Blood Eosinophil Count 0.3 2.4 4.9 -0.1 -1.2 -2.2 -1.9 -0.5 -2.1
Blood Platelet Count 0.0 0.4 0.9 0.4 -0.8 -0.5 0.3 0.9 -0.4
Blood Red Count 0.1 1.2 4.7 -2.2 1.5 0.6 0.1 -0.2 -0.0
Blood White Count 0.2 1.4 3.4 -1.2 1.8 -1.3 -1.1 -0.4 -0.9
Heel T-Score 0.2 2.0 4.0 0.6 -0.2 -1.9 -2.0 -1.3 -1.4
BMI 0.5 2.7 5.5 1.1 -2.3 -2.4 -1.6 -1.2 -0.1
Height 0.4 7.0 26.5 -5.1 -1.9 2.4 1.9 1.5 0.5
Waist Hip Ratio (WHR) 0.1 0.5 1.1 -1.0 1.0 -0.5 -0.7 0.0 0.4
Systolic Blood Pressure 0.0 0.2 0.6 0.6 0.8 0.7 0.3 0.1 -0.0
Smoking Status 0.3 0.8 1.4 -1.2 0.9 -0.7 -1.0 -0.9 -0.7
Allergy or Eczema 0.5 1.2 3.1 0.2 -0.1 1.8 0.8 0.7 -1.8
Cardiovascular Disease 0.5 1.7 3.9 1.0 -0.2 -1.3 -1.6 -2.0 -1.1
Hypothyroidism (self reported) 0.2 0.4 1.5 1.2 0.0 0.5 0.2 0.6 -0.5
Respiratory disease 0.2 0.4 1.0 -0.7 -0.3 0.2 0.5 1.0 0.7
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.2 -0.1 1.5 -0.4 -0.8 -0.6 -0.3
Lung FEV1/FVC ratio 0.2 0.9 4.8 -0.4 2.2 0.2 -0.4 0.1 0.3
Lung FVC 0.1 0.5 1.4 -0.2 0.5 1.2 0.7 -0.7 -0.2
Neuroticism 1.5 3.5 7.5 -2.7 -2.2 -1.6 -1.6 -1.8 -0.9
Chronotype (morning person) 0.2 0.5 2.1 -0.5 -0.3 0.4 0.0 -0.4 -1.5
Hair Pigment 0.0 0.3 0.8 0.2 0.4 0.8 0.2 -0.9 0.1
Tanning 0.0 0.3 0.7 -0.5 0.0 -0.9 -0.4 -0.6 0.7
Hand grip strength (left) 0.9 2.3 4.7 -0.9 -1.5 0.6 1.7 1.8 2.2
Number of treatments/medications taken 0.2 0.3 1.4 -0.5 -1.2 0.1 -0.2 0.5 0.4
Average weekly spirits intake 1.3 1.6 3.7 -1.9 0.0 0.1 -0.7 -1.9 -1.4
Sensitivity / hurt feelings 1.5 2.5 9.2 -0.6 -3.0 -0.4 0.7 1.5 1.7
Frequency of depressed mood in last 2 weeks 1.2 1.7 6.0 -0.6 0.6 -0.2 -1.2 -1.4 -2.4
Hearing difficulty/problems: Yes 1.0 1.5 3.5 0.2 -0.1 -1.5 -1.7 -1.9 -0.6
Relative age of first facial hair 0.5 1.0 3.4 0.9 1.8 1.1 0.6 0.0 -0.3
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 2.3 0.6 1.3 1.0 1.5 1.1 0.6
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.8 -0.7 0.0 0.2 -0.1 -0.3 0.9
Ever had hysterectomy (womb removed) 1.3 1.4 3.3 0.2 0.5 0.8 1.2 1.8 1.7
Systolic blood pressure, automated reading 0.2 0.6 1.2 -0.8 0.5 1.1 0.8 -0.4 -0.9
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 3.1 -0.1 1.8 0.9 -0.4 -1.1 -0.4
Angina 0.5 0.6 1.3 -1.0 1.0 0.0 0.6 1.1 0.2
Medication for hormone replacement therapy 0.9 1.0 2.5 0.6 -1.2 -0.4 -1.0 -0.9 -1.6
Vitamin and mineral supplements 2.5 3.4 7.1 -0.6 2.2 -0.7 -1.8 -2.1 -2.7
Supplements: Zinc 0.8 0.9 2.1 -1.4 -1.1 0.3 0.4 0.1 1.3
Medication: Co-codamol 0.6 0.7 2.1 -0.8 0.0 0.9 1.5 0.7 -0.2
Medication: Metformin 0.2 0.3 0.8 0.1 0.9 -0.5 -0.6 -0.7 -0.3
Diabetes (father) 1.1 1.3 4.3 1.4 -2.1 -1.1 -0.7 -0.1 -0.1
Diabetes (mother) 0.8 1.0 2.6 -0.4 0.8 -1.6 -1.4 -0.7 -0.0
Severe depression (siblings) 0.2 0.2 0.7 0.8 0.1 0.5 0.2 -0.1 -0.5
Pack years adult smoking proportion 0.8 1.2 4.8 -0.6 2.2 0.5 0.4 0.8 -0.9
Impedance of leg (right) 0.1 0.4 1.0 -0.4 -0.5 1.0 0.1 0.3 -0.9
Leg fat-free mass (left) 0.3 1.3 2.8 -1.4 -1.7 0.3 1.1 1.1 0.9
Trunk fat percentage 0.1 0.4 1.0 -0.6 -0.4 -1.0 -0.7 -0.2 -0.5
Hand grip strength (right) 0.1 0.4 1.0 -0.3 -1.0 0.6 0.7 0.4 0.1
Townsend deprivation index at recruitment 1.0 1.5 2.1 -1.4 1.2 1.5 1.0 0.8 1.3
Current tobacco smoking 0.5 0.9 2.1 -1.5 0.8 -0.5 -0.6 0.9 1.0
Average weekly fortified wine intake 1.1 1.3 7.0 2.6 -0.1 0.5 0.0 0.5 -0.2
Maternal smoking around birth 1.6 2.3 9.3 0.1 0.3 -3.0 -2.1 0.2 0.4
Fed-up feelings 1.0 1.8 3.2 -1.8 -1.2 -1.3 -1.6 -1.2 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.7 0.7 0.7 0.7 0.2 -0.3 -1.3
Relative age voice broke 0.4 0.6 1.3 1.2 0.4 0.8 0.7 0.6 0.7
Taking other prescription medications 0.7 1.1 2.8 1.7 1.1 1.2 0.2 0.2 -1.0
Age when periods started (menarche) 0.2 0.4 1.3 0.6 0.2 -0.4 -0.6 -1.1 -0.1
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.9 0.4 0.3 1.0 0.2 0.4 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.1 -0.2 0.7 0.2 -0.2 -0.4 -1.0
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 4.9 -2.2 1.5 0.3 -0.6 -0.9 -0.6
Qualifications: CSEs or equivalent 0.6 0.8 2.4 -1.0 0.0 0.5 -0.3 -1.1 -1.5
Serious illness, injury or assault to yourself 0.3 0.4 1.3 0.3 -0.6 -0.5 -0.3 0.3 1.1
High blood pressure 0.6 1.6 4.2 0.4 0.3 -1.7 -2.0 -1.4 -0.5
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.8 0.6 0.2 1.3 0.3 -0.1 -1.2
Multivitamins +/- minerals 0.4 0.6 1.5 0.2 -1.2 0.0 0.8 0.6 0.9
Stomach or abdominal pain in last month 1.0 1.3 3.8 0.1 -0.1 -1.9 -0.5 0.9 1.6
Supplements: Glucosamine 1.4 1.8 4.0 -1.5 -1.5 0.2 1.2 2.0 0.7
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.9 0.6 0.3 -1.1 -0.9 0.1 1.7
Medication: Atenolol 0.7 0.8 2.7 -1.6 -0.4 -1.1 -0.3 0.0 0.9
Medication: Levothyroxine sodium 0.5 0.9 2.8 1.2 1.7 0.6 -0.2 0.8 0.3
Sitting height 0.6 4.1 12.3 -3.5 -1.8 1.6 1.7 1.4 1.2
Chronic bronchitis/emphysema (father) 1.3 1.6 3.1 0.1 1.4 1.8 1.7 1.2 0.2
High blood pressure (mother) 0.2 0.2 0.8 0.3 -0.2 -0.6 -0.1 -0.4 -0.9
Body mass index (BMI) 0.1 0.5 1.8 0.1 0.0 -1.4 -0.9 -0.6 -0.6
Impedance of leg (left) 0.1 0.3 0.9 0.1 -0.2 1.0 0.0 -0.3 -0.8
Leg predicted mass (left) 0.2 1.3 2.6 -1.4 -1.6 0.3 1.1 1.1 0.8
Trunk fat mass 0.1 0.4 1.2 -1.1 -0.7 -0.7 -0.3 0.1 -0.3
Waist circumference 0.1 0.2 0.4 -0.6 -0.6 -0.6 -0.3 0.4 0.0
Number of incorrect matches in round 0.3 0.4 0.7 0.5 -0.8 0.8 0.8 0.6 0.2
Past tobacco smoking 0.1 0.2 1.2 0.1 0.0 -0.1 -0.0 -0.0 1.1
Alcohol usually taken with meals 0.8 1.2 4.5 0.3 -2.1 -1.3 -1.0 -0.3 0.1
Nervous feelings 1.2 2.1 8.1 0.1 -2.9 -1.7 -1.2 -0.6 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.2 -0.1 -0.2 -0.8 -1.4 -1.2 -2.0
Hearing difficulty/problems with background noise 0.4 0.7 1.5 -0.7 -0.0 -0.6 -1.0 -1.2 -0.8
Hair/balding pattern: Pattern 2 0.7 0.8 3.2 -1.1 1.8 0.7 0.1 0.1 0.1
Had menopause 0.1 0.1 0.2 -0.3 0.5 -0.2 0.1 0.4 -0.0
Had other major operations 0.2 0.2 0.5 0.2 0.7 -0.4 -0.1 0.2 0.7
Forced vital capacity (FVC) 0.9 3.4 8.6 -0.5 -1.4 2.9 2.5 1.1 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.7 -0.2 -0.2 -0.6 -0.8 -0.5 -0.6
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 2.3 -0.2 -1.0 -1.5 -0.9 -1.5 1.0
Qualifications: None of the above 0.7 1.5 3.4 -1.9 1.0 -1.2 -0.8 1.1 1.3
Financial difficulties in last 2 years 0.9 1.2 5.9 -2.4 0.5 -0.7 0.1 0.6 0.7
Mouth/teeth dental problems 0.6 1.0 1.4 0.5 -0.9 1.2 1.1 1.1 1.0
Heart attack 0.5 0.6 1.5 -1.0 0.3 -0.1 0.7 0.8 1.2
Allergy 0.4 1.0 3.0 -1.1 -0.5 -1.7 -0.9 -0.7 0.6
Pain all over the body in last month 1.7 1.8 5.3 -0.8 1.2 2.3 1.7 0.7 -0.2
Diabetes (self-reported) 0.7 1.1 2.1 0.4 1.2 -1.2 -1.5 -1.0 0.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 -0.8 -0.2 0.8 0.2 -0.0 -0.7
Medication: Ramipril 0.7 0.9 2.0 0.8 1.4 -0.8 -1.0 -0.9 -0.5
Medication: Simvastatin 1.0 1.5 3.1 -0.0 1.8 -0.8 -1.6 -1.1 -1.2
Fluid intelligence score 0.7 1.5 3.2 1.8 -0.0 -1.4 -1.2 -1.2 -0.8
Illnesses of siblings 1.5 2.1 10.4 0.4 3.2 1.1 0.1 0.3 0.5
Neuroticism score 1.0 2.2 6.4 -2.5 -1.4 -1.5 -1.2 -0.7 -0.6
Weight 0.1 0.6 2.1 -1.5 -1.1 -0.3 0.2 0.3 -0.1
Impedance of arm (right) 0.1 0.2 0.5 0.7 0.0 0.5 0.2 0.6 0.4
Arm fat percentage (right) 0.1 0.3 1.4 0.2 -0.4 -1.2 -0.6 0.1 -0.4
Trunk fat-free mass 0.4 2.2 4.3 -2.1 -1.8 1.1 1.6 1.3 0.6
Hip circumference 0.1 0.4 1.8 -0.6 -1.3 -0.5 -0.0 0.2 -0.2
Time employed in main current job 2.1 2.4 6.7 0.9 -0.2 -1.1 -1.7 -1.7 -2.6
Alcohol intake versus 10 years previously 1.2 1.7 6.2 0.2 -0.1 -1.1 0.4 1.7 2.5
Father’s age at death 1.1 1.5 4.4 0.1 1.9 2.1 0.7 0.0 0.6
Worrier / anxious feelings 1.0 1.8 3.3 -1.8 -1.8 -1.5 -1.1 -1.1 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.1 -1.0 0.3 -0.6 -0.9 -0.6 -0.5
Falls in the last year 0.8 1.1 2.0 1.1 0.8 -1.4 -1.4 -0.8 -0.6
Hair/balding pattern: Pattern 3 1.7 2.5 5.0 1.2 0.0 2.2 2.2 1.8 0.8
Number of live births 0.2 0.3 1.6 1.3 -0.2 -0.4 -0.1 0.4 0.1
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 6.7 -0.3 -0.6 2.6 2.2 0.8 1.1
Pulse rate 0.3 0.4 1.5 1.2 0.7 0.2 0.2 0.1 0.7
Happiness 0.1 0.1 0.2 -0.1 0.5 -0.2 0.2 -0.4 -0.2
Noisy workplace 0.1 0.1 0.2 0.5 -0.4 0.1 0.1 -0.0 -0.2
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.6 1.3 0.8 -0.9 -1.3 -1.9 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.6 0.6 0.0 -0.1 0.1 0.8 1.3
Mouth/teeth dental problems: Dentures 0.2 0.4 1.1 -0.8 0.2 -1.1 -0.6 -0.1 0.5
Asthma 0.5 1.1 2.7 -0.1 0.8 1.6 1.3 0.9 -0.7
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 3.9 -2.0 -1.7 -0.2 0.4 0.9 1.1
Medication: Cholesterol lowering 2.0 3.0 8.8 1.6 0.8 -0.9 -1.8 -1.5 -3.0
Depression (self-reported) 0.1 0.1 0.3 0.5 0.3 -0.4 -0.5 -0.1 0.1
Medication: Lansoprazole 0.4 0.5 1.8 -0.0 -0.9 -0.6 0.3 1.3 0.3
Prospective memory result 0.5 0.6 1.6 -0.1 -0.1 0.1 0.9 1.0 1.3
Lung cancer (father) 0.7 0.8 1.7 -0.8 0.4 -1.3 -0.9 -0.8 1.1
Illnesses of mother 0.5 0.6 1.2 -0.8 0.9 0.8 0.5 1.1 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 9.8 -0.2 -1.2 3.1 2.9 1.4 1.1
Pulse wave Arterial Stiffness index 0.4 0.4 1.1 -0.3 -0.3 -0.7 -0.9 -1.1 0.3
Impedance of arm (left) 0.0 0.1 0.5 0.1 -0.0 0.7 0.1 0.5 -0.0
Arm fat mass (right) 0.0 0.2 0.5 -0.2 -0.7 -0.7 -0.1 0.2 -0.3
Trunk predicted mass 0.4 2.4 4.7 -2.2 -1.8 1.1 1.7 1.4 0.7
Standing height 0.5 4.9 11.6 -3.4 -2.5 2.1 2.1 1.6 0.8
Length of working week for main job 2.0 2.2 3.6 -1.0 -0.3 1.6 1.9 1.6 1.8
Exposure to tobacco smoke at home 0.6 0.6 1.5 0.9 -1.2 -0.3 -0.1 0.3 1.2
Breastfed as a baby 1.0 1.3 2.1 1.4 -1.1 -0.7 -0.4 -1.4 -1.4
Tense / ‘highly strung’ 0.8 1.3 3.1 -1.8 -0.7 -1.3 -1.1 -0.3 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 3.3 -0.8 -1.8 -1.1 -0.3 0.4 1.7
Hair/balding pattern: Pattern 4 1.1 2.6 7.1 -1.3 -0.7 -2.7 -1.9 -1.4 0.6
Birth weight of first child 0.4 0.8 3.8 -0.1 -0.5 -0.1 0.3 0.8 2.0
Peak expiratory flow (PEF) 0.2 0.5 1.1 -0.1 -0.4 1.0 1.0 0.2 0.7
Pulse wave reflection index 0.2 0.2 0.6 0.0 0.8 0.7 0.1 -0.5 -0.2
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 -0.8 0.1 -0.3 0.1 0.3 0.8
Loud music exposure frequency 1.6 1.8 3.6 -0.9 1.0 -1.2 -1.8 -1.9 -0.6
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.7 1.9 0.5 0.7 0.4 0.1 -1.1
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 2.3 -1.0 1.3 -0.7 -1.2 -1.4 -1.5
Blood clot in the leg (DVT) 0.6 0.7 2.3 1.5 0.2 0.5 0.5 1.1 0.6
Medication: Paracetamol 1.3 2.2 8.1 0.6 -2.8 0.1 1.3 1.1 1.3
Headache pain in last month 0.4 0.6 2.3 0.0 -1.5 -0.2 0.0 0.7 -0.9
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 5.0 -1.0 -0.8 0.3 1.2 1.1 2.2
Glaucoma (self-reported) 0.3 0.4 0.8 0.1 0.9 -0.8 -0.9 0.0 -0.1
Gout (self-reported) 2.3 3.1 6.5 0.2 2.2 -1.2 -2.2 -2.5 -1.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 3.0 1.7 0.9 0.5 -0.4 0.2 -0.4
Medication: Amlodipine 0.5 0.6 1.7 1.3 1.1 -0.0 -0.5 -0.7 -0.6
Medication: Ventolin 100micrograms inhaler 0.5 0.6 2.4 -0.9 1.5 0.1 -0.0 -0.1 -0.6
Birth weight 0.5 1.1 3.6 -0.4 -1.9 -1.1 -0.2 -0.3 1.3
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.2 -1.1 -0.6 0.5 0.8 0.6 -0.1
High blood pressure (siblings) 0.7 1.0 4.6 -0.9 -2.1 0.1 0.7 -0.1 -0.5
Forced vital capacity (FVC), Best measure 1.2 4.2 9.9 -0.5 -1.8 3.1 2.9 1.3 1.3
Body fat percentage 0.1 0.5 1.3 -0.5 -0.6 -1.1 -0.8 -0.1 -0.6
Leg fat percentage (right) 0.2 0.7 1.4 -0.6 -0.6 -1.2 -1.1 -0.3 -1.0
Arm fat-free mass (right) 0.4 1.8 4.5 -2.1 -1.5 1.0 1.4 1.0 0.3
Exposure to tobacco smoke outside home 0.6 0.9 3.0 -1.7 1.1 -0.1 -0.4 0.6 0.7
Comparative body size at age 10 0.3 0.8 2.5 0.6 0.3 -1.6 -0.7 0.4 1.0
Number of full brothers 0.4 0.5 1.4 -0.7 -0.1 -1.1 -1.2 -0.0 -0.4
Worry too long after embarrassment 0.4 0.7 1.6 -1.3 -1.1 0.6 0.1 1.0 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 5.8 -2.4 -0.2 -0.5 -0.4 -0.2 1.1
Wheeze or whistling in the chest in last year 0.2 0.4 1.3 -0.2 0.5 0.0 0.0 1.2 -0.8
Number of children fathered 1.2 1.3 4.8 0.0 0.2 0.9 1.3 2.2 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.3 1.5 -1.0 1.2 1.3 1.1 0.3
Age at first live birth 2.3 4.0 8.4 1.1 0.6 -1.2 -2.5 -2.9 -2.5
Pulse wave peak to peak time 0.4 0.4 1.2 -0.2 -0.1 0.7 0.8 1.1 -0.4
Health satisfaction 0.2 0.2 0.9 -0.1 -0.3 -0.1 -0.4 -0.4 -1.0
Shortness of breath walking on level ground 1.7 2.1 4.4 0.3 1.7 -1.0 -1.5 -2.1 -1.3
Qualifications: College or University degree 0.3 0.9 3.1 1.2 -1.8 0.2 0.3 -0.2 0.9
Eye problems/disorders: None of the above 0.1 0.1 0.4 -0.3 -0.4 -0.7 -0.0 0.4 -0.2
Mouth/teeth dental problems: Loose teeth 0.2 0.2 1.2 -0.3 -0.0 0.1 -0.2 -0.3 -1.1
Emphysema/chronic bronchitis 0.3 0.4 1.4 0.6 0.1 -1.2 -0.7 0.2 0.0
Medication for pain relief, constipation, heartburn 0.8 1.3 4.3 0.7 2.1 -0.0 -1.1 -1.1 -0.8
Neck or shoulder pain in last month 0.6 0.8 3.3 -1.8 -0.5 0.6 0.3 0.9 -0.3
Medication: Blood pressure 1.3 2.3 5.1 1.1 0.4 -1.7 -2.2 -1.5 -1.5
Angina (self-reported) 0.4 0.5 1.8 -1.4 1.0 -0.3 0.2 0.6 -0.0
Migraine (self-reported) 0.3 0.3 1.1 -0.2 1.0 -0.6 -0.2 0.6 0.1
Medication: Ibuprofen 1.3 1.6 4.1 -2.0 -1.5 -0.2 0.5 1.3 1.0
Medication: Allopurinol 1.2 1.6 3.3 -0.3 1.8 -1.2 -1.5 -1.5 -0.6
Medication: Omeprazole 0.3 0.3 1.3 1.1 -0.1 -0.1 0.2 0.6 0.5
Medication: Seretide 50 evohaler 0.5 0.5 1.1 1.0 -1.0 0.8 0.8 0.0 -0.2
Mean time to correctly identify matches 0.5 1.0 1.5 0.9 -0.8 -1.2 -1.1 -1.2 -0.8
Heart disease (mother) 0.8 1.0 2.3 1.4 -1.5 -0.3 0.9 0.8 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.1 0.1 -1.1 -0.0 -0.3 0.1 -1.0
Whole body fat mass 0.1 0.3 0.6 -0.8 -0.7 -0.7 -0.2 0.2 -0.3
Leg fat mass (right) 0.1 0.3 0.9 -0.6 -0.9 -0.7 -0.3 0.0 -0.4
Arm predicted mass (right) 0.3 1.7 6.0 -2.4 -1.0 0.9 1.3 0.8 0.1
Pulse rate, automated reading 0.1 0.4 1.8 0.5 1.3 0.3 -0.3 -0.2 0.2
Alcohol intake frequency. 0.4 0.9 3.9 -1.1 2.0 -0.2 0.1 -0.1 0.1
Comparative height size at age 10 0.6 3.1 8.1 -2.7 -2.9 0.6 0.8 1.2 0.8
Number of full sisters 0.5 0.6 2.4 0.1 -0.1 -0.5 0.6 0.7 1.6
Suffer from ‘nerves’ 0.7 1.1 2.8 -0.8 0.5 -0.7 -1.3 -1.7 -1.0
Overall health rating 0.6 1.4 3.1 0.2 -0.0 0.9 1.2 1.8 1.7
Chest pain or discomfort 0.2 0.3 1.0 -0.6 1.0 -0.1 0.0 -0.7 0.0
Had major operations 0.7 0.8 2.0 0.6 -0.9 0.7 0.8 0.7 1.4
Age at last live birth 1.6 2.3 5.0 0.4 1.4 -0.5 -1.8 -2.2 -1.8
Family relationship satisfaction 0.3 0.4 1.7 0.1 -0.4 -0.3 0.7 1.3 0.2
Leg pain on walking 0.3 0.4 1.5 0.2 -0.5 1.2 0.7 -0.1 -0.2
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.4 -1.4 1.8 1.0 0.8 0.6 0.0
Commuting to job workplace: Car/motor vehicle 0.5 0.6 2.1 0.9 -0.0 1.5 0.9 0.1 -0.0
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.9 1.3 0.9 1.4 0.7 -1.0 -1.1
Medication: Aspirin 0.2 0.2 0.4 -0.5 0.3 -0.3 -0.4 -0.6 -0.5
Supplements: Vitamin C 2.0 2.3 4.5 0.3 -1.2 1.4 1.5 1.9 2.1
Knee pain experienced in last month 0.8 1.2 2.9 -0.0 -1.7 -0.1 0.6 1.1 1.7
Hypertension (Self-reported) 0.6 1.6 3.7 0.1 -0.0 -1.5 -1.9 -1.6 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.8 0.0 -0.0 0.4 -0.4 0.3 -1.4
Illnesses of father: Heart disease 0.4 0.6 2.4 0.1 0.2 0.6 0.4 0.5 -1.6
Illnesses of siblings: Diabetes 1.5 1.9 5.6 0.3 -2.4 -1.4 -1.5 -0.8 -1.0
Smoking status: Previous 0.6 1.0 4.3 0.1 -0.2 -0.3 -0.5 -1.0 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 5.6 -0.8 -2.4 1.7 1.4 1.7 0.5
Whole body fat-free mass 0.3 2.0 3.1 -1.8 -1.8 0.9 1.6 1.3 0.8
Leg fat-free mass (right) 0.2 1.2 2.2 -1.2 -1.5 0.3 1.2 0.9 1.1
Arm fat percentage (left) 0.1 0.4 1.1 -0.0 -0.4 -1.0 -0.6 0.0 -0.7
Average weekly red wine intake 0.3 0.4 1.4 1.2 -0.1 -0.3 -0.1 -0.8 0.3
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.5 -0.3 0.1 -0.4 -0.6 -0.7 -1.2
Mood swings 1.0 1.9 5.2 -2.3 -1.6 -1.6 -0.8 -0.4 0.7
Loneliness, isolation 1.0 1.3 2.5 -1.6 -0.2 -1.4 -1.6 -0.6 -0.8
Long-standing illness, disability or infirmity 0.4 0.5 1.6 -0.3 0.5 -0.5 0.3 1.0 1.2
Ever had bowel cancer screening 1.0 1.1 3.4 1.0 -0.3 0.2 0.8 1.3 1.8
Diabetes diagnosed by doctor 0.3 0.6 1.4 -0.2 1.0 -0.6 -1.2 -0.8 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.6 -0.7 1.2 1.6 1.1 0.9 0.7
Friendships satisfaction 0.1 0.2 0.8 0.4 -0.3 -0.1 0.2 -0.9 -0.0
Qualifications: nursing, teaching 0.5 0.8 1.6 1.1 -0.6 -0.1 -0.6 -1.1 -1.3
Commuting to job workplace: Walk 0.8 0.9 2.4 -1.4 -0.6 0.8 -0.0 -0.6 -1.6
Eye problems/disorders: Cataract 0.5 0.6 2.4 0.5 -1.5 -0.5 -0.2 -0.5 0.7
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.4 -0.2 0.4 0.1 -0.3 -1.0 -1.2
Medication for cholesterol 3.7 5.6 14.2 -0.8 0.1 2.0 3.0 3.8 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.3 5.8 -0.6 -0.5 1.2 2.3 2.4 0.7
Back pain experienced in last month 1.1 1.6 2.8 -1.1 0.7 1.2 1.7 1.6 1.0
Mineral and other dietary supplements 1.8 2.4 7.5 -0.9 2.7 -0.1 -1.1 -1.1 -2.0
Breast cancer (self-reported) 0.3 0.3 0.6 -0.1 0.5 0.8 0.6 0.7 0.6
Asthma (self-reported) 0.7 1.4 4.0 -0.0 0.7 2.0 1.6 1.0 -0.6
Osteoporosis (self-reported) 0.2 0.3 0.6 0.7 0.8 0.3 -0.1 -0.1 -0.7
Osteoarthritis (self-reported) 0.4 0.5 0.9 0.9 0.5 -0.2 0.5 0.8 0.9
Medication: Aspirin 0.2 0.3 0.8 0.1 0.4 -0.4 -0.6 -0.9 -0.6
Medication: Gliclazide 0.4 0.4 1.1 -0.0 -0.7 -0.4 -0.9 -1.0 0.3
Illnesses of father: None of the above (group 1) 0.5 0.6 2.2 -0.9 0.0 0.1 0.4 -0.5 1.5
Smoking status: Current 0.6 0.9 2.1 -1.2 0.5 -0.2 -0.1 1.2 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 3.1 0.7 -1.6 1.6 1.8 0.4 1.3
Whole body water mass 0.3 1.9 3.8 -1.9 -1.7 0.8 1.5 1.3 0.7
Leg predicted mass (right) 0.2 1.2 2.4 -1.2 -1.5 0.3 1.1 0.9 1.1
Arm fat mass (left) 0.1 0.3 0.9 -0.5 -0.7 -0.9 -0.4 0.2 -0.3
Number of self-reported non-cancer illnesses 0.4 0.7 2.6 0.3 1.6 0.9 0.5 0.7 -0.2
Average weekly champagne plus white wine intake 1.0 1.4 3.4 1.8 -0.8 1.4 1.4 0.6 0.5
Miserableness 0.8 1.4 2.7 -1.6 -1.7 -1.4 -0.6 0.2 -0.5
Guilty feelings 0.6 0.9 2.9 -0.2 -1.7 0.0 0.6 1.1 0.8
Wears glasses or contact lenses 1.5 1.7 5.2 -1.3 0.1 0.9 1.0 1.3 2.3
Ever taken oral contraceptive pill 0.5 0.6 1.6 1.0 -1.2 -0.2 -0.1 -0.1 -1.0
Hearing aid user 1.7 1.9 3.2 1.2 1.0 -1.4 -1.8 -1.2 -1.6
Mother’s age at death 1.0 1.2 4.1 -0.3 2.0 0.4 -0.6 -1.2 -1.1
Financial situation satisfaction 0.7 0.9 4.9 -2.2 0.3 -0.3 0.2 0.2 0.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.6 0.5 -1.0 -1.2 -0.7 0.5 -0.3
Commuting to job workplace: Public transport 0.2 0.2 0.6 -0.2 0.5 0.1 0.5 0.8 0.4
Eye problems/disorders: Glaucoma 0.6 0.7 2.3 -1.3 1.5 0.5 0.1 0.3 -0.2
Medication: Blood pressure 1.1 2.2 6.8 0.3 0.2 -1.3 -1.8 -2.6 -1.1
Pain type(s) experienced in last month: Hip pain 0.8 1.0 4.5 -2.1 0.1 -0.6 -0.1 -0.4 1.0
Supplements: Fish oil (including cod liver oil) 1.5 2.0 8.5 1.0 -2.9 -0.0 0.5 -0.0 1.5
High cholesterol (Self-reported) 1.7 3.0 6.3 1.4 0.2 -1.8 -2.5 -2.0 -1.5
Medication: Bendroflumethiazide 0.5 0.8 3.1 1.3 -1.8 0.2 0.2 0.2 0.3
Medication: Paracetamol 0.9 1.4 2.7 0.8 -1.6 0.6 1.4 1.3 1.2
Medication: Lisinopril 2.1 2.8 4.2 1.1 1.8 -0.9 -1.9 -1.9 -2.0
Medication: Atorvastatin 1.1 1.3 5.3 2.3 -0.4 0.1 -0.6 -0.9 -1.1
Illnesses of father: High blood pressure 0.6 0.7 1.8 0.7 0.2 1.3 0.5 0.2 -1.2
Alcohol drinker status: Never 0.9 1.1 2.0 -1.2 0.6 -1.4 -1.2 -0.3 1.1
Ever smoked 0.4 0.7 1.8 -0.7 1.3 -0.0 -0.6 -0.5 -1.1
Basal metabolic rate 0.3 1.7 3.1 -1.8 -1.7 0.7 1.3 1.2 0.6
Leg fat percentage (left) 0.2 0.7 1.3 -0.3 -0.4 -1.1 -1.1 -0.6 -1.0
Arm fat-free mass (left) 0.3 1.8 4.5 -2.1 -1.3 1.0 1.4 1.0 0.4
Number of operations (self-reported) 0.1 0.2 0.7 -0.8 -0.3 0.1 -0.6 -0.2 -0.4
Average weekly beer plus cider intake 0.3 0.4 1.3 -0.5 0.8 -0.4 0.1 1.1 0.1
Irritability 0.1 0.2 0.6 -0.4 -0.8 0.2 -0.2 0.1 -0.8
Risk taking 0.5 0.7 1.5 1.2 0.0 0.8 1.2 0.5 0.7
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.1 -0.7 0.9 1.8 1.7 1.2 -0.5
Fractured/broken bones in last 5 years 0.9 1.2 2.1 -0.5 0.9 -1.2 -1.3 -1.4 -0.9
Age started oral contraceptive pill 0.1 0.1 0.3 0.5 -0.3 -0.2 0.0 -0.6 -0.0
Diastolic blood pressure, automated reading 0.2 0.7 1.7 -0.6 0.1 1.3 1.3 0.7 0.2
Ever depressed for a whole week 0.6 0.8 1.6 -1.0 -1.0 -0.8 -0.2 -0.7 1.3
Unable to work because of sickness or disability 1.8 2.4 4.6 -2.2 -0.2 0.4 1.1 2.0 2.0
Commuting to job workplace: Cycle 1.8 2.1 8.5 0.0 -1.1 -0.0 0.8 1.6 2.9
Myopia 0.3 0.5 0.7 0.8 -0.7 -0.8 0.0 0.8 0.9
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.4 -0.3 -1.0 1.4 1.5 1.0 0.5
Cholesterol lowering medication 1.7 2.6 5.7 0.1 2.4 -1.0 -1.9 -2.1 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.8 0.6 -0.6 -0.0 0.5 0.6 0.9
Pain experienced in last month 1.2 2.0 5.5 0.7 1.2 -0.5 -1.3 -1.7 -2.3
Supplements: Calcium 0.3 0.3 0.6 0.2 -0.5 0.8 0.7 0.6 0.4
Basal cell carcinoma (self-reported) 0.5 0.6 1.1 -0.2 -1.0 -0.1 0.9 1.0 0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.3 -1.0 0.6 -0.1 0.7 0.8 1.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.8 1.3 0.2 0.4 0.5 1.3 0.7
Heart disease (siblings) 0.7 0.9 1.8 1.3 -1.1 -0.6 0.5 1.1 0.9
Alcohol drinker status: Previous 1.0 1.1 4.4 0.2 1.0 -0.2 -0.9 -2.1 -0.7
Pack years of smoking 0.7 1.0 4.0 -0.5 2.0 0.5 0.3 0.3 -1.2
Impedance of whole body 0.0 0.2 0.9 -0.0 0.1 0.9 0.1 0.1 -0.5
Leg fat mass (left) 0.1 0.3 0.7 -0.4 -0.9 -0.5 -0.2 -0.2 -0.5
Arm predicted mass (left) 0.3 1.5 3.7 -1.9 -1.2 0.8 1.4 1.0 0.7