Hub : Genes

VDAC2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0710 0.0260 3.3e-04 0.091 NA 0.057 NA 0.072 7.0e-08 NA 1.8e-05 NA 1.6e-06
2 GTEx Adipose Visceral Omentum 0.1210 0.0510 2.3e-03 0.014 NA 0.017 NA 0.019 5.9e-02 NA 4.5e-02 NA 3.6e-02
3 GTEx Artery Tibial 0.0536 0.0246 7.2e-03 0.002 NA 0.002 NA -0.003 2.0e-01 NA 2.0e-01 NA 6.3e-01
4 GTEx Cells Transformed fibroblasts 0.0750 0.0320 3.3e-03 0.031 NA 0.030 NA 0.031 2.1e-03 NA 2.3e-03 NA 2.0e-03
5 GTEx Muscle Skeletal 0.0753 0.0278 3.5e-04 0.043 NA 0.055 NA 0.037 4.6e-05 NA 3.9e-06 NA 1.5e-04
6 GTEx Nerve Tibial 0.0654 0.0278 3.3e-03 0.073 NA 0.058 NA 0.074 7.0e-06 NA 5.8e-05 NA 5.9e-06
7 GTEx Testis 0.2690 0.0630 2.8e-08 0.081 NA 0.239 NA 0.099 1.9e-04 NA 5.5e-11 NA 3.6e-05
8 GTEx Whole Blood 0.0470 0.0220 5.2e-03 0.053 NA 0.047 NA 0.050 1.2e-05 NA 3.7e-05 NA 2.1e-05
9 METSIM Adipose 0.0994 0.0291 8.0e-12 0.112 0.082 0.088 0.086 0.116 2.2e-16 2.7e-12 3.7e-13 8.6e-13 6.7e-17
10 YFS Blood 0.0113 0.0061 1.2e-02 0.010 0.005 0.003 0.005 0.009 2.6e-04 5.7e-03 4.0e-02 8.0e-03 5.9e-04
11 TCGA Breast Invasive Carcinoma 0.0362 0.0178 6.1e-05 0.013 0.021 0.023 NA 0.019 9.0e-04 2.4e-05 1.1e-05 NA 6.7e-05
12 TCGA Brain Lower Grade Glioma 0.0210 0.0121 2.5e-03 0.016 0.020 0.012 NA 0.012 5.7e-03 2.4e-03 1.4e-02 NA 1.6e-02
13 TCGA Liver Hepatocellular Carcinoma 0.1180 0.0710 7.1e-03 0.032 0.023 0.002 NA 0.019 1.1e-02 3.0e-02 2.4e-01 NA 4.3e-02
14 TCGA Lung Squamous Cell Carcinoma 0.0506 0.0340 1.8e-03 0.037 0.022 0.025 NA -0.002 4.2e-05 1.4e-03 6.6e-04 NA 9.0e-01
15 TCGA Prostate Adenocarcinoma 0.0423 0.0271 7.6e-03 0.003 0.011 0.018 NA 0.006 1.5e-01 2.0e-02 5.0e-03 NA 7.6e-02
16 TCGA Thyroid Carcinoma 0.0520 0.0340 3.2e-03 0.015 0.002 0.012 NA 0.012 1.1e-02 1.7e-01 2.2e-02 NA 2.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 1.0 1.6 3.5 -1.4 -1.9 -1.7 -1.8 -1.3 -0.8 -0.7 -1.0 -1.3 1.4 -1.2 -1.4 -0.8 -1.3 0.0 -0.7
Bipolar Disorder or Schizophrenia 0.2 0.4 1.6 0.1 -1.2 -0.3 -0.3 -0.0 1.2 0.1 0.2 -0.1 -0.1 0.7 -0.1 0.3 0.2 1.3 0.8
Depressed Affect (Nagel 2018) 1.1 2.3 8.2 -1.4 -1.1 -2.4 -1.5 -0.6 -1.7 -1.7 -1.1 -1.3 1.2 -2.0 -1.6 -2.9 -0.0 -0.4 -0.4
Depression (Nagel 2018) 0.5 0.7 2.4 0.1 -1.0 -1.5 -0.5 0.8 -1.6 -0.6 0.5 0.2 -0.4 -0.1 -0.9 -1.2 0.6 -0.6 0.7
Intelligence (Savage-Jansen 2018) 0.8 2.4 5.6 -1.6 0.9 -1.6 -2.2 -2.2 -1.0 -0.7 -2.1 -2.3 1.5 -1.1 -2.4 -1.0 -1.3 0.1 -0.1
Neuroticism (Nagel 2018) 1.1 2.7 6.5 -1.9 -1.2 -2.6 -1.5 -0.8 -1.8 -1.7 -1.5 -1.6 1.7 -1.8 -1.7 -2.5 -0.8 -1.0 -1.0
Schizophrenia (2018) 0.8 1.6 4.8 1.3 -0.1 0.9 1.1 1.0 2.2 0.7 1.1 1.0 -1.2 1.8 1.0 1.1 1.3 1.6 1.6
Schizophrenia vs Biploar Disorder 1.1 1.4 6.1 0.6 2.0 1.8 1.3 1.0 2.5 1.4 0.3 0.4 -0.4 0.3 1.4 0.5 1.0 0.6 0.3
Worry (Nagel 2018) 0.3 0.7 2.0 -0.8 -1.2 -1.4 -0.4 0.2 -1.4 -0.4 -0.6 -0.4 0.6 -0.3 -0.7 -0.5 -0.9 -1.1 -0.9
Alzheimer’s Disease (in mother) 1.0 1.2 2.9 -1.1 -1.2 -1.7 -1.6 -0.4 -1.1 -1.1 -1.4 -1.4 1.0 -0.8 -1.3 -0.8 -0.8 -0.1 -0.1
Alzheimer’s Disease (in father) 1.4 1.5 3.8 0.9 -0.8 1.0 1.8 0.9 1.1 1.6 0.7 1.0 -0.7 1.7 1.9 1.9 0.3 1.5 0.2
Alzheimer’s Disease (including proxy) 0.4 0.5 1.8 0.4 -1.4 -0.1 0.7 0.7 0.3 0.5 -0.2 0.2 -0.3 1.2 0.8 0.7 0.4 1.3 0.7
Crohns Disease (2017) 0.3 0.6 4.1 0.4 -0.7 0.5 0.5 1.2 -0.4 2.0 0.6 0.4 -0.5 0.7 0.1 -0.2 0.7 0.6 0.8
Irritable Bowel Disease (IBD) 0.3 0.6 2.3 0.7 -1.0 0.2 0.5 1.1 -0.1 1.5 0.7 0.6 -0.8 1.2 0.3 0.1 0.6 0.9 0.8
Ulcerative Colitis (UC) 0.2 0.4 1.5 0.8 -0.4 0.2 0.5 0.6 0.3 0.6 0.6 0.7 -0.8 1.2 0.3 0.5 0.4 0.3 0.6
Major Depression (MDD) 3.9 4.8 7.8 -2.6 -0.6 -2.7 -2.4 -2.1 -2.8 -1.6 -2.4 -2.5 2.5 -2.3 -2.3 -1.9 -1.9 -1.5 -1.8
Reaction Time 1.3 2.4 4.8 1.1 2.1 1.9 2.1 1.5 1.3 2.0 0.9 1.4 -1.0 0.3 2.1 1.0 2.2 1.3 1.2
Verbal and Numeric Reasoning (VNR) 1.3 3.2 8.0 -1.7 0.7 -2.4 -2.7 -2.0 -1.4 -1.5 -2.0 -2.3 1.6 -1.2 -2.8 -0.9 -2.0 -0.5 -0.5
Breast Cancer 0.6 1.4 4.0 -1.3 1.9 -1.0 -0.4 -1.2 -0.2 -0.4 -1.1 -0.8 1.4 -1.4 -0.2 -0.1 -1.5 -1.5 -2.0
Ovarian Cancer 0.9 1.1 2.8 1.3 -1.1 0.4 1.1 1.1 -0.9 0.5 1.7 1.5 -1.5 1.0 0.8 -0.3 1.4 -0.3 0.6
Prostate Cancer 2.1 2.9 6.4 2.0 1.0 1.3 1.3 2.3 1.3 1.3 1.6 1.5 -2.1 2.2 1.0 0.3 2.4 1.6 2.5
Age at First Birth 1.3 1.8 4.3 1.5 1.2 1.7 1.1 1.4 1.0 2.1 1.5 1.6 -1.5 1.1 1.4 1.6 1.0 0.4 0.8
Bipolar Disorder (2011) 0.4 0.4 1.7 0.8 -0.0 -0.3 -0.3 0.1 0.6 -0.4 0.9 0.5 -0.8 0.9 -0.5 0.1 0.5 0.9 1.3
Body Mass Index (BMI) (2010) 0.8 1.1 4.1 -1.0 0.0 -1.4 -0.9 -0.2 -0.3 -1.3 -1.1 -1.2 1.0 -1.0 -1.4 -2.0 -0.6 -1.1 -0.5
Coronary Artery Disease (CAD) 2.1 2.5 4.6 1.6 0.7 1.8 1.4 1.8 1.9 1.9 1.5 1.4 -1.5 2.2 1.6 1.9 1.3 1.1 1.3
Crohns Disease (2012) 0.2 0.3 1.1 0.1 -0.6 0.5 0.8 0.7 0.1 1.1 0.5 0.4 -0.2 0.8 0.5 0.2 0.5 0.4 0.6
Mean Putamen Volume 0.8 0.9 3.0 -1.2 0.6 -0.9 -0.2 -0.8 -0.8 -0.4 -1.0 -0.7 1.3 -0.6 -0.0 0.5 -1.7 -1.1 -1.7
Fasting Glucose 0.3 0.3 1.1 -0.7 -1.1 -0.2 -0.2 0.4 -0.1 -0.2 -1.0 -0.9 0.7 -0.2 -0.0 -0.4 0.2 0.9 0.2
HbA1C 1.0 1.1 3.0 0.5 0.8 1.2 0.6 1.3 0.9 1.0 1.1 0.5 -0.5 1.1 0.7 0.4 1.7 1.5 1.7
HDL Cholesterol 4.2 7.0 12.7 2.9 1.5 2.5 2.6 2.9 1.9 2.8 2.9 2.8 -2.9 3.6 2.4 2.5 2.5 2.2 2.7
LDL Cholesterol 0.3 0.5 1.2 -0.8 0.3 -0.4 -0.9 -0.7 0.3 -0.7 -0.6 -1.0 0.8 -0.1 -1.1 -0.8 -0.8 -0.5 -0.2
Lupus 0.7 1.0 4.0 -0.7 -0.1 -1.4 -0.6 -0.8 0.5 -1.5 -0.3 -0.6 0.8 1.2 -1.0 1.4 -2.0 -0.8 -0.6
Neuroticism (2016) 1.6 2.3 4.4 -1.9 0.2 -1.8 -1.6 -1.0 -1.2 -1.6 -1.6 -1.6 1.8 -2.1 -1.6 -2.0 -0.9 -1.1 -1.1
Primary Biliary Cirrhosis 0.7 1.0 2.4 1.1 -1.3 1.1 1.1 1.3 1.5 -0.1 1.0 1.0 -1.0 1.3 1.1 0.4 0.6 0.6 0.2
Rheumatoid Arthritis 0.1 0.1 0.4 -0.1 0.4 -0.0 0.3 -0.2 0.4 -0.1 -0.2 0.1 0.2 0.4 0.4 0.7 -0.5 -0.1 -0.2
Schizophrenia (2014) 0.6 1.2 7.5 0.9 -0.4 0.7 0.7 0.9 2.7 0.3 0.8 0.6 -0.8 1.6 0.6 1.3 0.6 1.4 1.2
Triglycerides 1.8 3.0 5.1 -1.7 1.2 -1.4 -1.8 -1.7 -0.9 -2.3 -1.9 -2.1 1.7 -1.7 -2.2 -2.0 -1.5 -1.9 -1.1
Type 2 Diabetes (T2D) (2012) 2.0 2.3 6.4 -1.3 -0.8 -1.6 -0.8 -1.1 -1.4 -2.0 -1.1 -1.0 1.3 -0.7 -1.4 -1.2 -2.2 -2.5 -2.0
Ulcerative Colitis 0.3 0.5 1.7 0.7 0.2 0.1 0.6 0.4 0.9 0.5 0.6 0.7 -0.6 1.3 0.6 1.3 0.1 0.8 0.6
Blood Eosinophil Count 0.1 0.9 6.0 -0.6 2.4 -1.0 -0.8 -1.6 0.2 -0.7 -0.3 -0.6 0.6 -0.7 -1.0 -0.4 -1.0 -0.5 -0.6
Blood Platelet Count 0.7 8.4 24.6 -3.3 5.0 -1.4 -1.6 -3.4 0.7 -1.4 -3.5 -3.1 3.4 -3.7 -1.9 -2.3 -2.1 -3.5 -2.9
Blood Red Count 0.1 0.7 1.3 0.8 0.9 1.1 1.1 0.6 0.4 -0.5 0.8 0.9 -0.8 0.9 1.0 1.1 0.8 0.4 0.7
Blood White Count 0.1 0.4 5.1 -0.2 2.3 -0.3 0.6 -0.1 0.5 -0.5 -0.0 0.2 0.1 0.2 0.5 0.6 0.0 -0.4 -0.2
Heel T-Score 0.3 2.3 4.4 1.4 2.1 1.5 2.0 1.5 0.5 1.3 1.6 2.0 -1.4 1.7 1.9 2.1 0.6 0.4 0.7
BMI 2.3 13.6 25.8 -4.8 0.2 -4.0 -3.5 -3.6 -1.2 -2.4 -5.1 -5.0 4.9 -3.9 -3.7 -3.7 -3.5 -2.2 -3.1
Height 0.2 3.9 29.7 -0.9 -2.4 -3.1 -1.3 1.0 -5.5 -1.1 -0.3 -0.4 0.3 -0.7 -1.8 -2.4 -0.3 -1.8 0.2
Waist Hip Ratio (WHR) 0.1 0.4 1.1 0.6 -1.1 0.7 0.3 -0.7 0.1 0.3 0.9 0.7 -0.6 0.4 0.5 1.1 0.0 0.5 -0.1
Systolic Blood Pressure 1.5 7.4 24.4 -2.2 -1.2 -3.3 -3.4 -3.1 -4.9 -2.7 -1.8 -2.3 1.9 -3.1 -3.4 -3.0 -1.8 -1.2 -0.8
Smoking Status 0.7 1.8 7.3 -0.8 -2.7 -1.6 -1.0 -0.6 -2.2 -1.8 -0.6 -0.7 0.5 -0.8 -1.5 -1.9 -0.4 -0.9 -0.5
Allergy or Eczema 0.4 1.2 2.1 -1.0 -1.2 -1.3 -1.2 -1.3 -0.1 -1.0 -1.2 -1.3 1.1 -0.5 -1.5 -1.1 -1.4 -0.3 -0.7
Cardiovascular Disease 0.7 2.4 7.1 -1.6 0.4 -1.8 -1.5 -1.2 -2.7 -1.0 -1.4 -1.4 1.3 -2.2 -1.6 -2.0 -0.6 -1.5 -0.9
Hypothyroidism (self reported) 2.9 6.7 14.1 -2.4 -1.5 -3.6 -2.9 -1.9 -2.8 -3.2 -2.5 -2.8 2.2 -1.9 -3.7 -3.8 -1.8 -1.6 -0.7
Respiratory disease 4.3 9.5 14.3 -3.4 -1.5 -3.2 -3.5 -3.2 -1.7 -3.0 -3.1 -3.3 3.4 -3.8 -2.8 -3.1 -3.2 -2.7 -3.5
Type 2 Diabetes (T2D) (2018) 2.1 3.9 8.5 -2.3 0.7 -2.0 -1.8 -1.7 -1.1 -1.9 -2.0 -2.1 2.3 -2.9 -1.4 -2.2 -1.4 -2.0 -2.3
Lung FEV1/FVC ratio 0.1 0.5 3.1 0.7 0.8 0.3 0.5 -0.2 -1.8 0.2 0.7 0.8 -0.8 1.1 -0.2 0.1 0.0 -0.7 0.7
Lung FVC 2.2 11.3 23.3 -4.1 -0.2 -3.0 -2.4 -3.5 -2.4 -3.3 -4.2 -3.7 4.1 -2.4 -3.0 -3.0 -3.6 -4.8 -3.5
Neuroticism 0.3 0.7 4.0 -0.4 -1.5 -1.0 -0.1 0.8 -1.6 -0.3 -0.1 -0.1 0.1 -0.7 -0.3 -2.0 0.8 -0.0 0.0
Chronotype (morning person) 0.4 0.8 2.1 -1.1 0.4 -0.1 -0.3 -1.0 -0.4 -0.5 -1.4 -0.9 1.1 -1.0 -0.4 -0.3 -1.1 -1.3 -1.4
Hair Pigment 0.1 2.6 8.4 -1.5 -2.9 -2.6 -1.4 -0.8 -1.8 -2.0 -1.1 -1.2 1.4 -1.5 -1.1 -1.5 -1.4 -0.6 -1.1
Tanning 0.0 0.2 1.2 0.0 1.1 0.3 0.0 -0.4 -0.1 0.4 -0.5 -0.0 -0.0 -0.3 -0.1 -0.1 -0.4 -0.7 -0.4
Hand grip strength (left) 0.1 0.4 2.8 0.4 -1.7 -0.5 -0.3 0.1 -1.0 -0.6 0.5 0.3 -0.5 0.4 -0.4 -0.2 -0.4 -0.5 0.0
Number of treatments/medications taken 3.1 5.6 9.6 -2.9 -1.2 -2.7 -2.4 -2.0 -1.9 -3.0 -3.1 -2.9 2.8 -2.1 -2.6 -2.0 -2.0 -1.5 -1.5
Average weekly spirits intake 1.4 1.8 5.6 -1.3 -2.4 -1.4 -1.3 -0.9 -1.9 -1.0 -1.2 -1.5 1.2 -1.1 -1.6 -1.7 -0.3 0.4 0.2
Sensitivity / hurt feelings 0.8 1.4 3.1 -1.5 -0.3 -1.2 -0.4 -0.9 -1.0 -1.2 -1.2 -1.0 1.5 -1.5 -0.6 -1.2 -1.1 -1.4 -1.8
Frequency of depressed mood in last 2 weeks 0.6 0.9 3.1 0.9 -0.2 -0.2 0.7 1.8 -0.3 0.3 1.0 0.9 -1.0 1.3 0.3 0.3 1.1 0.8 1.5
Hearing difficulty/problems: Yes 1.6 2.4 7.5 0.9 0.9 1.2 1.8 2.1 1.4 2.7 0.6 0.9 -0.9 2.2 1.4 1.9 0.9 1.6 1.6
Relative age of first facial hair 8.0 16.4 25.5 4.4 0.1 4.4 4.0 4.8 2.4 4.9 4.5 4.4 -4.5 3.2 4.1 2.5 5.0 4.4 4.2
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 2.2 -1.1 -0.9 -1.3 -1.4 -1.1 -1.2 -0.9 -1.1 -1.4 1.0 -0.8 -1.5 -1.2 -0.8 0.0 -0.2
Ever used hormone-replacement therapy (HRT) 0.5 0.7 2.3 -0.0 -1.4 -0.4 -0.8 0.5 -0.3 -0.8 -0.1 -0.5 -0.1 0.7 -1.4 -1.2 0.5 0.7 1.5
Ever had hysterectomy (womb removed) 0.3 0.4 2.0 0.4 -0.4 -0.3 -0.3 -0.1 1.4 -1.4 0.7 0.2 -0.4 0.4 -0.5 0.6 -0.1 0.0 0.5
Systolic blood pressure, automated reading 2.6 7.5 16.7 -2.6 -1.3 -3.1 -3.2 -3.0 -4.1 -3.1 -2.3 -2.6 2.4 -3.2 -3.5 -2.7 -2.2 -1.3 -1.1
Eye problems/disorders: Diabetes related eye disease 3.5 3.9 8.0 -2.3 0.9 -1.9 -1.6 -2.1 -1.3 -1.1 -2.5 -2.2 2.3 -1.9 -1.8 -0.8 -2.2 -2.8 -2.4
Angina 1.7 2.3 5.5 -1.5 -1.4 -2.3 -1.9 -0.4 -2.4 -1.1 -1.3 -1.7 1.4 -1.4 -1.9 -1.8 -1.0 -0.1 -0.5
Medication for hormone replacement therapy 0.2 0.2 0.7 -0.3 0.9 -0.2 -0.5 -0.2 -0.3 0.8 -0.3 -0.5 0.3 0.4 -0.8 0.0 -0.4 -0.1 0.2
Vitamin and mineral supplements 0.9 1.2 4.1 -1.4 0.6 -0.6 -1.0 -0.8 1.1 -0.1 -1.5 -1.2 1.6 -2.0 -0.2 -0.1 -1.1 0.0 -1.5
Supplements: Zinc 1.2 1.3 2.8 1.4 0.9 0.5 1.0 1.0 -0.5 1.2 1.7 1.5 -1.6 1.2 0.5 1.2 1.0 0.2 1.3
Medication: Co-codamol 0.8 0.9 2.0 -0.8 -1.3 -0.9 -1.2 -0.7 0.6 -1.2 -1.0 -1.1 0.7 -1.1 -0.9 -1.4 -0.2 -0.6 -0.4
Medication: Metformin 2.1 2.9 5.3 -2.0 -0.1 -1.7 -1.9 -1.8 -1.0 -1.3 -1.9 -1.9 2.1 -2.3 -1.3 -1.5 -1.6 -1.6 -2.1
Diabetes (father) 0.4 0.5 1.7 -1.1 -0.0 -0.4 -0.3 0.5 -0.6 -0.3 -1.3 -1.0 1.0 -0.7 -0.4 -1.1 -0.0 -0.1 -0.5
Diabetes (mother) 0.2 0.3 1.5 -0.1 0.2 0.6 0.5 1.2 0.3 -0.2 0.2 0.2 0.0 -0.1 0.4 -1.0 0.8 -0.6 0.0
Severe depression (siblings) 0.6 0.7 1.5 -1.0 0.5 -0.4 -0.4 -1.0 0.2 -1.2 -1.0 -0.8 1.1 -0.1 -0.3 0.2 -1.2 -1.2 -1.2
Pack years adult smoking proportion 3.2 5.0 7.7 -2.4 -0.3 -2.4 -2.4 -1.8 -1.6 -2.3 -2.1 -2.2 2.4 -2.7 -2.0 -2.2 -2.4 -2.4 -2.8
Impedance of leg (right) 0.1 0.6 4.5 0.7 -2.1 0.2 -0.4 0.2 -1.4 -0.3 1.0 0.7 -0.7 0.2 0.1 -0.2 0.2 0.3 0.1
Leg fat-free mass (left) 0.5 2.4 6.9 -2.0 0.8 -2.6 -0.8 -1.0 -1.5 -0.9 -2.1 -1.8 1.8 -1.4 -1.6 -2.0 -0.6 -1.4 -0.6
Trunk fat percentage 3.6 14.4 21.2 -4.4 -2.7 -4.6 -4.0 -3.5 -3.8 -3.2 -4.5 -4.6 4.2 -3.8 -4.4 -4.3 -3.0 -2.1 -2.3
Hand grip strength (right) 0.2 0.6 6.3 0.4 -2.5 -0.3 0.2 0.3 -1.0 -0.6 0.8 0.6 -0.5 0.3 0.2 -0.3 0.0 -0.6 -0.2
Townsend deprivation index at recruitment 0.8 1.1 2.9 -0.9 -0.8 -1.2 -0.7 -1.3 -1.4 -1.7 -1.1 -1.0 0.8 -0.6 -1.0 -1.5 -0.0 -0.6 -0.0
Current tobacco smoking 0.5 0.8 3.0 0.3 -1.7 -1.2 0.1 0.7 -1.7 -0.7 0.6 0.5 -0.7 0.2 -0.5 -1.4 0.8 0.0 0.8
Average weekly fortified wine intake 1.0 1.2 9.7 -0.6 -3.1 -1.6 -0.8 0.3 -1.5 -0.4 -0.8 -0.8 0.5 0.1 -0.9 -0.7 -0.3 0.7 0.3
Maternal smoking around birth 3.9 5.6 8.7 -2.5 -1.2 -2.4 -2.2 -2.3 -2.1 -2.3 -2.4 -2.5 2.4 -2.5 -2.5 -2.9 -1.9 -2.9 -2.2
Fed-up feelings 0.6 1.2 6.7 -0.7 -1.3 -1.3 -0.0 1.0 -1.8 -0.8 -0.3 -0.3 0.5 -1.4 -0.3 -2.6 0.8 -0.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 3.8 1.2 -0.7 0.2 1.2 1.9 -1.1 0.9 1.8 1.6 -1.5 0.8 0.9 -0.2 1.6 0.4 1.2
Relative age voice broke 2.7 4.2 8.6 1.7 -0.1 2.7 2.3 2.7 1.3 2.9 1.8 2.0 -1.8 0.5 2.7 1.0 2.8 2.1 1.5
Taking other prescription medications 7.2 11.1 17.6 -3.8 -1.2 -4.2 -3.2 -3.9 -3.2 -3.6 -3.6 -3.6 3.7 -3.2 -3.2 -2.6 -3.2 -2.9 -2.9
Age when periods started (menarche) 2.0 4.8 11.2 2.4 1.5 1.7 1.8 3.4 1.0 1.9 2.3 2.1 -2.6 2.1 1.5 0.5 3.2 1.8 3.0
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 2.0 1.2 -0.1 0.4 -0.1 0.3 1.1 -1.4 1.4 0.9 -1.3 1.3 -0.7 0.5 0.5 -0.2 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 1.1 0.3 1.1 0.1 -0.0 -0.0 -0.3 0.3 0.4 0.3 -0.3 0.5 0.0 0.6 0.1 0.7 0.7
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 6.1 0.1 2.5 0.0 -0.2 -0.5 0.1 0.1 0.1 -0.0 -0.0 -0.0 -0.1 0.7 -0.2 0.4 0.3
Qualifications: CSEs or equivalent 0.1 0.1 0.3 -0.4 -0.2 -0.4 -0.0 -0.1 -0.2 -0.5 -0.5 -0.3 0.4 -0.3 0.2 -0.5 0.1 0.2 -0.2
Serious illness, injury or assault to yourself 1.8 2.2 5.4 -1.4 -2.3 -2.2 -2.0 -0.8 -1.5 -1.4 -1.4 -1.8 1.2 -1.1 -1.7 -1.8 -0.7 0.3 -0.6
High blood pressure 2.2 6.1 10.0 -2.9 -1.2 -3.2 -2.7 -2.0 -3.1 -2.2 -2.6 -2.9 2.6 -3.0 -3.0 -3.0 -1.3 -0.7 -0.8
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.3 -1.2 -1.8 -1.3 -1.3 -1.5 -0.7 -1.1 -1.5 -1.5 1.2 -0.7 -1.6 -1.4 -1.1 -0.5 -0.8
Multivitamins +/- minerals 0.7 0.9 3.7 1.3 -0.2 0.4 0.6 0.4 -0.4 0.4 1.4 1.0 -1.4 1.9 -0.0 0.1 0.9 0.3 1.5
Stomach or abdominal pain in last month 1.6 1.9 3.2 -1.7 -0.2 -1.7 -0.9 -1.4 -0.3 -1.8 -1.5 -1.3 1.8 -1.6 -0.7 -1.3 -1.1 -1.6 -1.7
Supplements: Glucosamine 1.4 1.8 4.2 1.5 0.5 1.4 1.6 2.0 1.0 1.5 1.4 1.4 -1.5 1.4 1.4 0.3 1.6 0.4 1.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 3.4 -0.0 1.8 -0.0 0.1 -0.1 0.5 0.3 -0.3 0.1 0.1 1.0 0.2 1.9 -0.7 0.4 0.3
Medication: Atenolol 1.7 2.1 3.7 -1.9 0.3 -1.3 -1.4 -1.3 -1.0 -1.3 -1.7 -1.8 1.9 -1.4 -1.4 -0.5 -1.8 -1.2 -1.7
Medication: Levothyroxine sodium 3.3 5.6 13.2 -1.6 -0.8 -3.2 -2.5 -2.1 -3.4 -3.4 -1.7 -1.9 1.3 -1.7 -3.6 -3.5 -1.4 -2.0 -0.2
Sitting height 0.1 0.4 2.5 -0.1 1.6 -0.3 0.7 -0.1 -0.8 -0.0 -0.1 0.3 -0.0 -0.5 0.5 -0.5 0.8 -0.8 0.2
Chronic bronchitis/emphysema (father) 0.4 0.5 3.1 -0.1 -1.0 -0.1 0.2 1.8 -0.3 -0.3 -0.3 -0.2 0.0 -0.2 0.3 -1.1 1.0 0.7 0.3
High blood pressure (mother) 0.3 0.4 1.3 -0.2 -0.6 -0.6 0.2 -1.1 -1.1 -0.9 0.2 0.2 0.1 -0.2 0.0 0.1 -0.4 -0.9 -0.7
Body mass index (BMI) 2.4 10.4 20.2 -4.3 -0.1 -3.7 -3.1 -3.0 -1.6 -2.2 -4.5 -4.4 4.2 -3.4 -3.5 -3.3 -2.8 -1.7 -2.2
Impedance of leg (left) 0.2 1.0 5.7 1.2 -2.4 0.6 -0.1 0.3 -0.8 -0.2 1.6 1.2 -1.3 0.6 0.3 0.1 0.5 0.7 0.6
Leg predicted mass (left) 0.5 2.5 6.8 -2.1 0.9 -2.6 -0.8 -1.0 -1.6 -0.9 -2.1 -1.8 1.8 -1.5 -1.6 -2.0 -0.6 -1.5 -0.7
Trunk fat mass 3.1 13.2 21.6 -4.4 -2.0 -4.7 -3.7 -3.2 -3.6 -2.9 -4.4 -4.4 4.1 -3.8 -4.1 -4.3 -2.6 -2.1 -2.1
Waist circumference 2.5 9.0 15.1 -3.8 -0.9 -3.6 -3.0 -3.1 -2.2 -2.1 -3.8 -3.9 3.6 -3.2 -3.4 -3.4 -2.4 -1.6 -2.0
Number of incorrect matches in round 0.9 1.5 2.6 -1.5 -0.8 -1.2 -1.5 -1.1 -0.6 -1.4 -1.6 -1.6 1.5 -1.4 -1.0 -1.2 -0.8 -0.4 -1.1
Past tobacco smoking 1.6 3.0 7.2 2.0 1.7 1.2 1.4 1.8 0.7 2.1 2.0 2.2 -1.9 1.5 2.0 2.7 0.9 1.2 1.1
Alcohol usually taken with meals 0.1 0.2 0.8 0.3 0.5 0.5 0.2 -0.8 0.3 0.3 0.5 0.3 -0.2 0.7 0.1 0.9 -0.6 -0.1 -0.1
Nervous feelings 0.2 0.4 1.5 0.3 -0.6 0.2 1.0 1.2 -0.6 0.7 0.3 0.6 -0.4 0.9 0.7 0.7 0.2 0.4 0.1
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.2 7.0 1.7 -0.3 1.4 2.5 2.6 0.8 1.0 2.0 2.2 -1.8 2.1 2.1 1.1 2.1 1.3 1.5
Hearing difficulty/problems with background noise 0.6 0.9 3.0 0.5 -0.8 0.5 1.1 1.1 -0.1 1.7 0.6 0.7 -0.6 1.4 0.8 0.6 0.9 1.3 1.2
Hair/balding pattern: Pattern 2 0.2 0.3 0.9 -0.2 -0.9 -0.2 -0.5 -0.9 -0.7 -0.8 -0.1 -0.3 0.1 0.0 -0.7 -0.0 0.1 0.5 1.0
Had menopause 0.8 1.0 4.4 0.9 -1.3 0.2 0.1 0.9 0.0 0.4 1.0 0.5 -1.0 1.5 -0.4 0.5 0.8 1.6 2.1
Had other major operations 1.1 1.3 3.5 1.1 -1.2 1.5 1.8 1.6 0.4 0.3 1.0 1.2 -1.1 1.9 1.3 0.8 0.9 0.5 0.7
Forced vital capacity (FVC) 0.7 2.8 9.1 -1.5 -0.4 -1.9 -0.8 -1.3 -2.2 -2.4 -1.5 -1.3 1.4 -0.5 -1.6 -2.1 -1.2 -3.0 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 1.0 0.2 1.0 -0.3 -0.3 0.1 -0.4 -0.1 0.3 0.2 -0.2 0.3 -0.3 0.3 -0.1 0.4 0.6
Ever unenthusiastic/disinterested for a whole week 2.4 2.9 5.9 -1.9 0.0 -1.9 -1.7 -2.1 -0.8 -1.6 -1.6 -1.7 1.9 -2.4 -1.5 -1.7 -1.7 -1.6 -1.9
Qualifications: None of the above 0.5 1.0 11.4 -0.6 -3.4 -0.5 -0.1 -0.1 -1.1 -1.2 -0.5 -0.4 0.5 -0.1 -0.2 -0.4 -0.4 0.1 -0.4
Financial difficulties in last 2 years 0.4 0.6 2.3 -0.8 1.2 -0.5 0.4 -0.7 -0.1 0.5 -0.5 -0.1 0.8 -1.1 0.7 0.5 -0.6 -0.9 -1.5
Mouth/teeth dental problems 0.1 0.1 0.6 0.1 -0.8 -0.0 -0.3 0.0 -0.8 -0.3 0.3 0.1 -0.1 0.3 -0.4 0.1 -0.5 -0.5 -0.2
Heart attack 2.3 3.0 6.0 -2.1 -0.9 -1.8 -1.4 -1.2 -1.9 -1.6 -1.8 -1.8 2.1 -1.6 -1.2 -1.4 -2.1 -1.7 -2.5
Allergy 2.7 6.2 10.0 2.5 1.6 2.8 2.7 3.2 1.5 2.7 2.6 2.7 -2.5 2.5 2.7 2.4 2.5 2.0 2.3
Pain all over the body in last month 1.2 1.3 2.7 1.5 -0.8 0.7 0.5 1.3 0.3 1.2 1.6 1.4 -1.6 1.5 0.5 0.5 1.0 1.2 1.2
Diabetes (self-reported) 0.8 1.2 2.4 -1.2 1.6 -1.1 -0.8 -0.7 -1.1 -0.4 -1.1 -1.1 1.2 -1.4 -0.8 -1.4 -0.5 -1.3 -1.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 3.5 -0.6 -0.5 -0.8 -0.9 -1.9 0.3 -1.1 -0.6 -0.6 0.6 -1.2 -0.6 -0.9 -0.6 -0.5 -0.7
Medication: Ramipril 0.4 0.5 1.1 -0.8 0.2 -0.2 0.4 1.0 0.1 1.1 -0.7 -0.2 0.9 -0.6 0.8 0.9 -0.6 0.2 -1.0
Medication: Simvastatin 1.0 1.4 4.8 -1.2 -2.2 -1.2 -0.9 -0.1 -1.0 -1.0 -1.4 -1.4 1.1 -0.9 -1.1 -2.2 0.1 -0.2 -0.5
Fluid intelligence score 0.5 1.1 2.6 -0.9 0.5 -1.4 -1.4 -1.3 -0.7 -1.3 -1.0 -1.2 0.9 -0.1 -1.6 -0.0 -1.4 -0.3 -0.3
Illnesses of siblings 4.0 5.6 10.1 3.2 1.7 2.5 2.4 1.9 1.4 2.0 2.8 3.0 -3.2 2.8 2.1 1.9 2.3 1.2 2.4
Neuroticism score 0.3 0.7 3.4 -0.7 -1.2 -1.3 -0.1 0.8 -1.8 -0.5 -0.4 -0.2 0.4 -0.6 -0.2 -1.6 0.4 -0.3 -0.4
Weight 1.8 9.0 17.4 -3.7 -0.5 -4.2 -2.7 -2.4 -2.8 -2.3 -3.8 -3.7 3.5 -3.0 -3.4 -3.7 -2.1 -2.1 -1.6
Impedance of arm (right) 0.3 1.6 11.2 0.3 -3.3 -0.6 -0.9 -0.3 -2.9 -1.4 0.5 0.2 -0.5 0.4 -0.8 -0.7 -0.4 -0.5 -0.1
Arm fat percentage (right) 3.5 13.8 23.3 -4.6 -1.9 -4.3 -3.8 -3.5 -3.1 -3.1 -4.8 -4.8 4.4 -3.5 -4.1 -3.8 -3.2 -1.9 -2.5
Trunk fat-free mass 0.1 0.7 3.8 -1.0 2.0 -1.6 0.1 0.1 -0.5 0.1 -0.8 -0.5 0.8 -0.7 -0.4 -0.9 -0.0 -1.0 -0.2
Hip circumference 1.9 8.1 15.5 -3.4 -0.8 -3.9 -2.4 -2.6 -2.6 -2.3 -3.5 -3.4 3.2 -2.7 -3.3 -3.7 -2.0 -2.0 -1.5
Time employed in main current job 0.4 0.4 2.3 -0.6 0.8 -0.2 -0.1 0.3 1.5 0.3 -0.9 -0.8 0.8 -0.1 -0.2 -0.8 -0.2 -0.4 -0.6
Alcohol intake versus 10 years previously 0.9 1.4 2.6 -1.2 -1.1 -1.5 -1.0 -1.0 -1.4 -1.3 -0.9 -1.0 1.0 -1.6 -0.9 -1.5 -0.7 -0.9 -1.3
Father’s age at death 2.1 2.9 5.4 1.6 1.1 2.3 2.1 1.3 1.5 2.1 1.5 1.8 -1.5 1.6 1.9 2.1 1.3 1.5 1.4
Worrier / anxious feelings 0.2 0.3 1.3 -0.6 -0.7 -0.5 -0.0 0.1 -0.7 0.3 -0.2 -0.1 0.6 -0.5 -0.0 -0.5 -0.6 -0.9 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 1.3 -0.1 -0.4 -0.1 0.6 1.1 0.1 0.2 0.5 0.4 -0.0 0.2 0.5 -0.5 0.7 0.3 0.2
Falls in the last year 0.3 0.4 2.0 -0.2 1.4 -0.0 0.6 0.4 1.0 1.1 -0.1 -0.2 0.2 -0.1 0.3 0.1 0.7 0.8 0.4
Hair/balding pattern: Pattern 3 0.3 0.5 3.0 0.1 1.7 0.3 0.8 0.2 0.7 0.4 0.4 0.6 -0.0 -0.2 0.6 0.5 -0.4 -1.1 -0.9
Number of live births 0.5 0.8 3.7 -0.3 -1.9 -0.8 -1.0 -1.6 -0.2 -0.6 -0.4 -0.7 0.4 -1.0 -1.0 -0.5 -0.4 0.8 0.1
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 8.8 -1.2 -0.5 -1.9 -0.6 -1.3 -2.6 -2.1 -1.3 -1.0 1.0 -0.0 -1.5 -1.9 -1.3 -3.0 -1.1
Pulse rate 0.4 0.7 2.9 0.6 0.0 1.2 0.4 0.6 1.7 1.3 0.2 0.1 -0.5 0.8 0.2 0.6 0.5 1.5 1.1
Happiness 0.5 0.6 1.3 0.8 -1.1 0.0 0.8 1.1 -0.7 1.1 1.1 1.0 -0.8 0.1 0.6 -0.5 1.0 0.4 0.5
Noisy workplace 0.6 0.8 1.6 -0.9 -1.3 -0.7 -0.9 -0.6 -1.1 -1.2 -0.9 -1.0 0.9 -0.2 -1.1 -1.1 -0.9 -0.3 -0.3
Qualifications: A levels/AS levels or equivalent 1.1 2.4 7.4 1.9 2.7 1.3 1.2 1.0 1.1 1.3 1.8 1.7 -1.9 1.8 0.9 1.2 1.3 0.8 1.7
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.1 -0.9 0.5 -0.9 -1.3 -0.6 0.1 -0.7 -1.4 -1.5 0.9 -0.6 -1.3 -1.0 -0.8 0.4 -0.1
Mouth/teeth dental problems: Dentures 1.7 2.8 5.8 -1.9 0.2 -2.2 -1.9 -1.6 -0.4 -1.9 -2.3 -2.4 1.9 -1.1 -2.2 -1.8 -1.2 -0.8 -0.5
Asthma 3.6 7.0 13.0 -2.8 -1.0 -2.5 -2.6 -3.5 -0.8 -2.5 -2.5 -2.6 2.9 -3.2 -2.1 -2.1 -3.1 -2.9 -3.6
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 3.5 -0.7 0.4 -1.1 -1.1 -1.8 -0.5 -1.5 -0.7 -0.9 0.6 -1.9 -1.3 -1.8 -0.5 -1.5 -0.8
Medication: Cholesterol lowering 1.1 1.7 4.3 -1.3 -1.3 -1.5 -1.6 -0.4 -1.8 -0.7 -1.3 -1.4 1.2 -2.1 -1.2 -2.0 -0.0 -0.0 -0.6
Depression (self-reported) 0.5 0.7 4.3 -0.0 2.1 0.6 0.3 0.4 1.0 1.1 -0.0 0.2 0.2 -0.2 1.0 1.1 0.2 1.0 -0.0
Medication: Lansoprazole 0.5 0.6 1.9 -0.6 1.1 -0.5 -0.4 -0.9 -0.5 -0.4 -0.5 -0.5 0.6 -1.4 -0.2 -1.0 0.0 -1.1 -0.8
Prospective memory result 0.4 0.5 1.6 -1.0 -0.5 0.2 -0.4 -0.5 0.5 0.3 -1.3 -1.0 1.1 -0.8 -0.0 -0.1 -0.5 0.3 -0.8
Lung cancer (father) 0.6 0.8 8.1 0.1 -2.8 -0.4 0.3 0.9 0.2 -0.8 0.5 0.3 -0.1 0.1 0.3 -0.7 -0.1 -0.8 -0.7
Illnesses of mother 2.2 2.8 5.4 1.8 0.9 1.8 1.6 1.1 1.7 2.0 1.5 1.7 -1.7 2.3 1.4 2.3 0.8 1.7 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 3.4 0.0 0.2 -0.5 0.1 -0.2 -1.4 -0.5 -0.2 -0.1 -0.1 0.7 -0.7 -1.3 0.1 -1.8 0.1
Pulse wave Arterial Stiffness index 0.5 0.5 2.6 0.6 -0.0 1.0 0.4 -0.5 1.6 0.8 0.4 0.2 -0.5 0.3 0.4 0.6 0.9 0.8 0.9
Impedance of arm (left) 0.3 1.4 11.0 0.6 -3.3 -0.1 -0.4 0.1 -2.6 -1.0 0.9 0.7 -0.8 0.6 -0.3 -0.2 -0.1 -0.4 0.0
Arm fat mass (right) 2.5 10.5 18.2 -4.1 -1.0 -4.2 -3.3 -2.8 -2.6 -2.6 -4.3 -4.3 3.9 -3.2 -3.7 -3.5 -2.6 -1.5 -1.9
Trunk predicted mass 0.1 0.6 3.8 -0.8 1.9 -1.4 0.3 0.2 -0.4 0.2 -0.7 -0.4 0.7 -0.6 -0.3 -0.8 0.1 -1.0 -0.1
Standing height 0.1 1.5 8.2 0.8 -0.9 -1.4 0.7 1.1 -2.9 -0.2 1.2 1.3 -1.2 0.7 0.1 -1.2 1.3 -0.9 1.0
Length of working week for main job 2.5 2.8 8.2 -1.1 -1.2 -1.6 -1.3 -1.2 -1.8 -2.9 -0.7 -0.9 1.0 -0.7 -1.7 -1.9 -1.7 -2.9 -2.0
Exposure to tobacco smoke at home 0.4 0.5 1.4 0.0 -0.4 0.3 0.7 -0.6 -0.7 -0.9 0.5 0.7 -0.0 -1.0 0.7 -0.0 -0.3 -1.1 -1.2
Breastfed as a baby 1.1 1.3 5.6 0.7 0.5 1.5 0.8 0.4 1.1 2.4 0.7 0.8 -0.6 0.7 1.1 2.1 0.5 1.4 1.0
Tense / ‘highly strung’ 0.1 0.2 0.7 -0.5 0.4 -0.4 0.3 0.6 -0.7 0.3 -0.3 -0.1 0.4 -0.2 0.3 -0.3 -0.1 -0.8 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 3.1 4.7 9.6 -2.2 -1.1 -3.1 -2.5 -2.7 -2.0 -2.3 -2.1 -2.4 2.1 -2.1 -2.6 -2.7 -1.2 -1.0 -1.0
Hair/balding pattern: Pattern 4 0.6 1.5 4.9 -1.1 1.7 -0.6 -1.1 -2.2 0.6 1.2 -1.2 -1.4 1.2 -2.0 -0.6 -1.0 -0.6 -0.7 -1.2
Birth weight of first child 1.4 2.5 5.9 -1.6 -1.1 -1.8 -2.1 -1.2 -1.5 -1.3 -1.8 -2.0 1.4 -1.5 -2.4 -2.4 -0.5 -0.7 -0.0
Peak expiratory flow (PEF) 1.7 3.9 9.0 -2.0 -0.2 -2.7 -1.8 -2.1 -3.0 -1.7 -1.8 -1.8 1.8 -0.7 -2.4 -1.8 -2.1 -2.4 -1.2
Pulse wave reflection index 0.3 0.3 0.8 0.6 0.0 0.8 0.6 -0.2 0.5 0.4 0.7 0.8 -0.6 0.0 0.9 0.5 0.9 0.1 0.3
Ever highly irritable/argumentative for 2 days 2.1 2.5 4.7 -1.5 -1.7 -2.1 -1.9 -1.9 -2.2 -1.4 -1.2 -1.5 1.3 -0.8 -2.0 -1.6 -1.5 -0.7 -0.8
Loud music exposure frequency 0.4 0.5 1.6 0.4 1.1 0.8 1.0 -0.4 0.8 0.4 0.3 0.4 -0.3 1.1 0.4 1.3 -0.3 -0.5 -0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.5 0.1 1.2 -0.8 -0.3 0.0 -1.0 -0.2 0.2 0.1 -0.2 0.5 -0.9 -0.4 -0.3 -1.0 0.4
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 2.3 1.3 0.6 1.0 1.3 1.1 1.2 1.3 1.2 1.4 -1.2 0.5 1.5 1.0 1.5 1.4 1.0
Blood clot in the leg (DVT) 0.2 0.2 0.9 0.5 0.4 -0.4 -0.2 0.1 -0.7 -0.2 0.7 0.3 -0.6 0.4 -0.4 0.4 0.4 0.5 1.0
Medication: Paracetamol 5.7 9.4 16.6 -3.2 -1.3 -3.1 -3.2 -3.3 -2.8 -3.1 -3.2 -3.3 3.2 -3.6 -3.3 -4.1 -2.4 -2.4 -2.4
Headache pain in last month 0.1 0.2 0.7 0.1 0.2 0.2 0.6 0.1 0.7 0.3 -0.2 0.1 -0.0 -0.3 0.4 -0.6 0.8 0.0 0.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 2.7 1.3 0.7 1.1 0.8 -0.4 0.9 -0.6 1.4 1.1 -1.2 1.6 0.1 0.8 0.1 -0.3 0.9
Glaucoma (self-reported) 0.3 0.4 0.9 -0.7 0.4 -0.4 -0.6 -0.8 -0.0 -0.7 -0.9 -0.9 0.8 -0.5 -0.6 0.1 -0.8 -0.4 -0.4
Gout (self-reported) 1.0 1.4 3.2 -1.1 1.0 -1.4 -1.8 -1.5 -0.7 -1.1 -1.4 -1.6 1.1 -0.2 -1.6 0.1 -1.4 0.3 -0.1
Hypothyroidism/myxoedema (self-reported) 2.5 4.8 11.3 -1.9 -1.1 -3.0 -2.2 -1.8 -3.0 -2.6 -2.0 -2.1 1.6 -1.5 -3.3 -3.4 -1.2 -1.6 -0.1
Medication: Amlodipine 1.3 1.9 3.6 -1.5 -0.1 -1.4 -1.2 -1.0 -1.4 -1.7 -1.9 -1.8 1.5 -1.6 -1.8 -1.7 -0.6 -0.5 -0.1
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.7 0.3 0.2 0.0 -0.3 -0.6 0.8 -0.4 0.2 0.0 -0.3 -0.3 -0.2 -0.2 0.0 0.5 0.0
Birth weight 0.2 0.4 2.0 0.7 0.8 0.4 -0.2 0.5 -0.5 0.2 0.3 0.3 -0.8 1.1 -0.8 -0.2 0.5 -0.0 1.4
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.5 -0.1 -0.9 -0.6 -0.7 0.1 -0.5 -1.0 0.3 -0.1 0.0 -1.2 -0.5 -1.2 0.6 0.5 0.2
High blood pressure (siblings) 1.0 1.4 2.6 -1.6 -1.3 -1.6 -1.1 -0.7 -0.3 -1.3 -1.4 -1.5 1.6 -1.1 -1.2 -0.9 -1.2 -0.2 -0.8
Forced vital capacity (FVC), Best measure 0.2 0.8 5.9 -0.6 0.5 -0.6 0.2 -0.4 -0.9 -0.9 -0.7 -0.4 0.5 0.1 -0.5 -1.3 -0.3 -2.4 -0.8
Body fat percentage 3.8 15.1 24.0 -4.7 -2.2 -4.5 -4.0 -3.7 -3.3 -3.3 -4.8 -4.9 4.5 -3.9 -4.4 -4.2 -3.2 -2.2 -2.5
Leg fat percentage (right) 3.6 12.9 23.0 -4.6 -0.9 -4.0 -3.6 -3.5 -2.4 -2.7 -4.8 -4.8 4.5 -4.0 -3.9 -3.9 -2.9 -1.9 -2.5
Arm fat-free mass (right) 0.2 1.0 3.5 -1.4 1.5 -1.9 -0.3 -0.3 -0.4 -0.2 -1.3 -1.1 1.2 -1.0 -0.9 -1.3 -0.1 -0.8 -0.1
Exposure to tobacco smoke outside home 2.1 2.8 5.0 -2.2 -0.7 -1.8 -1.7 -1.5 -0.9 -1.4 -2.2 -2.2 2.2 -1.3 -1.4 -0.4 -2.1 -1.6 -1.8
Comparative body size at age 10 0.3 1.0 2.6 0.9 0.0 1.2 1.4 1.6 0.9 0.9 0.6 0.9 -0.9 0.5 1.3 0.2 1.4 0.4 0.6
Number of full brothers 1.2 1.5 3.9 -1.5 0.1 -0.9 -0.9 -1.4 -0.1 -0.7 -1.6 -1.4 1.6 -1.7 -0.4 -0.5 -1.2 -1.1 -2.0
Worry too long after embarrassment 0.4 0.6 2.3 -0.8 -1.5 -0.9 -0.4 -0.2 -0.8 -0.2 -0.9 -0.7 0.8 -1.0 -0.1 -1.3 0.0 -0.2 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 2.5 -1.0 -0.4 -1.6 -0.7 -0.2 -1.2 -0.1 -1.1 -1.0 0.9 -0.4 -0.9 -0.6 -0.8 0.6 -0.0
Wheeze or whistling in the chest in last year 1.4 2.4 6.1 -2.0 -0.7 -1.9 -1.3 -1.4 -0.3 -1.1 -1.8 -1.7 2.0 -2.5 -0.9 -2.0 -1.1 -0.8 -1.8
Number of children fathered 2.2 2.4 4.0 -1.6 0.2 -1.7 -1.8 -1.7 -1.9 -1.3 -1.5 -1.5 1.5 -1.4 -1.8 -1.1 -2.0 -1.6 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.2 -0.7 0.3 0.3 -0.8 -1.0 0.9 0.1 -0.9 -1.1 0.8 -0.8 -0.6 -0.2 -0.7 -0.1 -0.5
Age at first live birth 6.6 11.6 21.0 3.6 3.3 4.0 3.7 3.0 2.9 4.6 3.6 3.9 -3.6 3.1 3.8 3.0 3.3 1.7 2.5
Pulse wave peak to peak time 0.7 0.8 3.7 -0.8 -0.2 -1.3 -0.7 0.4 -1.9 -1.0 -0.5 -0.4 0.7 -0.5 -0.7 -0.9 -1.1 -1.1 -1.0
Health satisfaction 0.6 0.7 2.3 -0.3 -0.6 -1.4 -0.8 -0.8 -1.5 -1.0 -0.1 -0.4 0.1 -0.8 -1.4 -1.1 -0.0 -0.8 0.2
Shortness of breath walking on level ground 1.6 1.9 4.7 -1.3 0.2 -2.2 -2.1 -1.2 -0.2 -1.5 -1.3 -1.5 1.2 -1.5 -1.9 -1.2 -1.0 -1.1 -0.7
Qualifications: College or University degree 0.8 2.7 10.9 1.8 3.3 1.3 1.4 0.2 1.9 1.6 1.6 1.6 -1.6 1.6 1.4 2.2 0.9 0.4 0.9
Eye problems/disorders: None of the above 7.6 8.7 14.0 2.9 1.7 3.5 3.5 3.1 2.9 3.5 2.8 3.2 -2.8 2.9 3.7 3.1 2.5 2.2 1.9
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.4 0.3 0.2 -0.7 -0.0 -0.0 0.1 -0.1 0.3 0.3 -0.3 -0.3 0.1 0.0 0.4 -0.3 -0.0
Emphysema/chronic bronchitis 2.9 3.2 7.2 -2.0 -1.2 -1.9 -1.6 -1.8 -1.4 -2.2 -2.0 -2.0 1.9 -2.5 -1.5 -2.7 -0.7 -0.9 -1.3
Medication for pain relief, constipation, heartburn 3.3 5.7 9.0 2.8 0.8 2.5 2.3 2.5 2.1 2.1 2.9 2.7 -2.7 3.0 2.3 2.9 1.8 1.8 2.0
Neck or shoulder pain in last month 0.1 0.1 0.5 0.0 -0.0 0.0 0.2 -0.0 0.7 0.2 0.3 0.2 0.1 -0.2 0.4 -0.2 0.1 -0.5 -0.5
Medication: Blood pressure 1.1 2.0 4.2 -1.8 -0.6 -1.9 -1.6 -0.6 -1.6 -0.1 -1.9 -1.8 1.7 -2.1 -1.1 -1.4 -0.8 -0.3 -1.1
Angina (self-reported) 2.0 2.6 7.8 -1.5 -1.8 -2.5 -1.9 -0.4 -2.8 -1.1 -1.2 -1.7 1.3 -1.4 -2.0 -2.1 -0.9 -0.2 -0.5
Migraine (self-reported) 3.4 4.2 10.1 -1.8 -2.0 -1.9 -2.2 -2.1 -3.2 -1.1 -1.9 -1.8 1.6 -3.1 -1.9 -2.6 -1.1 -1.5 -1.7
Medication: Ibuprofen 0.4 0.5 3.1 -0.2 -0.0 -0.8 -0.2 -1.8 -0.4 -1.0 -0.3 -0.2 0.2 -1.0 -0.6 -0.5 -0.4 -1.1 -0.4
Medication: Allopurinol 1.0 1.4 3.0 -1.4 1.4 -1.1 -1.3 -1.5 -1.0 -0.8 -1.7 -1.7 1.4 -0.8 -1.2 -0.3 -1.2 0.2 -0.4
Medication: Omeprazole 0.3 0.3 1.5 0.3 -0.0 -0.6 -1.2 -0.4 -0.2 0.3 0.2 -0.3 -0.3 0.4 -1.2 0.0 -0.3 0.7 0.8
Medication: Seretide 50 evohaler 1.1 1.3 8.6 -1.2 2.9 -0.1 -0.3 -0.8 0.5 -0.4 -1.2 -1.1 1.3 -1.2 -0.4 -0.1 -0.8 -1.1 -1.2
Mean time to correctly identify matches 2.2 4.1 6.5 2.0 2.0 2.5 2.4 2.0 1.8 2.2 1.7 2.0 -2.0 1.4 2.2 1.6 2.5 1.7 2.0
Heart disease (mother) 1.1 1.3 3.0 -1.4 -1.7 -0.8 -1.3 -0.6 -0.8 -0.9 -1.5 -1.5 1.4 -1.5 -0.8 -1.4 -0.6 -0.2 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 5.0 -0.6 -2.2 -1.9 -1.9 -0.8 -1.6 -1.6 0.0 -0.7 0.4 -0.6 -2.0 -1.3 -1.0 -0.5 -0.1
Whole body fat mass 3.0 12.4 20.5 -4.4 -1.6 -4.5 -3.5 -3.1 -3.1 -2.9 -4.4 -4.4 4.1 -3.6 -4.1 -4.0 -2.7 -2.0 -2.0
Leg fat mass (right) 2.9 11.1 19.7 -4.3 -0.5 -4.2 -3.3 -3.1 -2.4 -2.5 -4.4 -4.4 4.1 -3.5 -3.7 -3.7 -2.4 -1.6 -1.9
Arm predicted mass (right) 0.2 1.1 3.9 -1.3 1.6 -2.0 -0.4 -0.3 -0.6 -0.1 -1.2 -1.1 1.1 -1.2 -1.0 -1.4 -0.1 -0.8 -0.1
Pulse rate, automated reading 0.4 1.3 5.6 0.8 -2.0 0.0 -0.3 0.5 -0.2 0.3 0.8 0.1 -0.9 0.5 -0.8 -1.0 1.3 2.4 2.2
Alcohol intake frequency. 2.5 5.8 10.1 -2.6 0.1 -2.7 -2.6 -2.9 -2.5 -3.2 -2.4 -2.6 2.5 -2.2 -2.7 -1.7 -2.3 -2.2 -1.7
Comparative height size at age 10 0.1 0.6 1.7 0.7 -0.3 -1.3 0.3 0.3 -1.2 0.1 1.2 1.1 -1.0 1.0 0.1 0.5 0.4 -0.1 0.8
Number of full sisters 0.2 0.2 1.3 -0.3 -0.2 -0.3 -0.1 -0.4 -1.0 -0.7 0.0 -0.0 0.2 0.1 -0.6 -0.3 -0.2 -1.1 -0.1
Suffer from ‘nerves’ 0.2 0.3 0.9 0.2 -0.6 -0.3 0.3 0.9 -0.9 0.1 0.3 0.3 -0.4 0.9 -0.2 -0.5 0.6 -0.2 0.5
Overall health rating 0.7 1.6 4.9 -1.5 -0.1 -2.2 -1.3 -0.2 -1.3 -1.1 -1.2 -1.4 1.4 -1.6 -1.2 -1.9 -0.2 0.1 -0.4
Chest pain or discomfort 0.6 0.8 1.9 -1.2 -0.2 -0.9 -0.5 -0.2 -0.4 -1.4 -1.1 -1.0 1.2 -0.8 -0.6 -1.3 -0.6 -1.1 -1.1
Had major operations 0.4 0.4 3.9 -0.2 -2.0 -0.4 0.6 0.9 -0.5 -0.7 0.0 0.3 0.1 0.3 0.6 -0.0 -0.1 -0.1 -0.6
Age at last live birth 4.3 6.3 11.6 2.7 2.9 2.5 2.5 2.1 1.9 3.4 2.8 2.9 -2.6 2.3 2.8 2.8 2.2 1.1 1.8
Family relationship satisfaction 0.9 1.1 2.8 -1.3 -1.7 -1.6 -0.8 -1.1 -1.5 -0.8 -1.2 -1.1 1.2 -0.4 -0.9 -0.3 -0.9 -0.3 -0.6
Leg pain on walking 1.7 2.1 5.6 -1.5 -1.3 -1.9 -0.7 -0.6 -2.4 -1.4 -1.3 -1.4 1.2 -0.6 -1.9 -2.3 -0.4 -1.9 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 3.2 -0.3 -0.4 -0.1 -0.2 0.5 -0.7 -0.1 0.1 -0.1 0.2 -1.6 0.1 -1.8 0.7 -0.0 -0.6
Commuting to job workplace: Car/motor vehicle 0.5 0.6 4.3 0.2 1.0 1.0 0.7 -0.6 2.1 0.7 -0.0 0.1 0.0 0.1 0.9 0.8 -0.0 -0.2 -0.6
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.1 1.2 0.3 1.1 1.1 0.7 -0.0 0.3 1.5 1.4 -1.3 1.0 0.6 0.6 1.2 -0.1 1.3
Medication: Aspirin 1.7 2.3 6.0 -2.3 -0.5 -1.4 -1.2 -1.0 -1.3 -0.4 -2.4 -2.2 2.3 -1.5 -0.9 -0.9 -1.3 -0.6 -1.6
Supplements: Vitamin C 0.4 0.5 1.6 0.8 -0.5 0.1 0.6 0.1 -0.5 -0.3 1.3 1.0 -0.9 1.2 0.3 1.0 0.0 -0.7 0.2
Knee pain experienced in last month 0.7 1.0 3.3 1.0 -0.2 0.8 0.9 1.8 0.7 0.5 0.7 0.7 -1.1 1.3 0.6 -0.1 1.7 0.7 1.5
Hypertension (Self-reported) 2.5 7.0 10.4 -3.2 -0.8 -3.2 -2.9 -2.3 -3.0 -2.2 -3.0 -3.2 3.0 -3.2 -3.1 -3.0 -1.6 -1.1 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 3.1 0.2 -1.8 -0.8 -0.7 -0.6 -0.9 0.6 0.4 0.0 -0.4 0.3 -0.7 -0.1 0.2 0.5 0.8
Illnesses of father: Heart disease 1.3 1.8 4.0 -1.4 -0.2 -1.7 -1.8 -1.1 -1.5 -1.1 -1.4 -1.6 1.4 -0.6 -2.0 -1.1 -1.7 -0.7 -0.6
Illnesses of siblings: Diabetes 0.7 0.9 1.8 -1.1 -1.4 -1.2 -1.2 -1.1 -0.5 -0.3 -0.9 -1.2 1.1 -1.0 -0.7 -0.5 -0.8 0.8 -0.5
Smoking status: Previous 1.8 2.7 5.9 -1.7 -1.8 -1.0 -1.6 -1.7 -0.4 -2.4 -2.0 -2.1 1.7 -1.1 -2.1 -1.9 -1.2 -1.2 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.1 8.7 2.2 -0.7 0.6 2.1 3.0 -0.2 -0.4 2.3 2.4 -2.3 2.7 1.4 0.4 1.7 0.2 1.4
Whole body fat-free mass 0.2 1.3 4.1 -1.4 1.6 -2.0 -0.3 -0.4 -0.9 -0.4 -1.4 -1.1 1.2 -1.1 -0.9 -1.4 -0.2 -1.3 -0.4
Leg fat-free mass (right) 0.3 1.3 4.5 -1.5 1.0 -2.1 -0.4 -0.6 -1.1 -0.6 -1.5 -1.2 1.2 -1.0 -1.2 -1.6 -0.2 -1.1 -0.2
Arm fat percentage (left) 3.4 13.4 22.7 -4.5 -1.6 -4.3 -3.7 -3.4 -3.1 -2.9 -4.8 -4.7 4.4 -3.7 -4.1 -3.7 -3.2 -2.0 -2.5
Average weekly red wine intake 2.2 3.2 7.5 1.9 0.4 2.0 2.2 1.0 1.4 2.3 1.8 2.2 -1.8 2.1 2.2 2.7 0.8 0.9 0.8
Handedness (chirality/laterality): Left-handed 0.4 0.5 2.0 0.5 0.7 -0.6 -0.8 0.2 -1.1 -0.7 0.5 0.0 -0.6 1.0 -0.8 -0.2 0.3 0.7 1.4
Mood swings 1.1 1.9 5.4 -1.3 -0.5 -2.3 -1.6 -0.8 -1.8 -1.7 -0.9 -1.2 1.1 -1.5 -1.5 -2.2 -0.3 -0.7 -0.4
Loneliness, isolation 0.2 0.2 0.7 -0.1 0.7 -0.0 0.6 0.4 -0.2 0.6 -0.0 0.1 0.1 -0.1 0.4 -0.9 0.9 0.5 0.4
Long-standing illness, disability or infirmity 2.4 3.7 7.3 -2.5 0.6 -2.7 -1.8 -1.5 -2.2 -1.5 -2.7 -2.4 2.4 -1.8 -1.7 -1.3 -1.5 -1.1 -1.3
Ever had bowel cancer screening 0.5 0.6 2.4 0.4 0.4 0.6 1.6 0.7 1.0 0.7 0.3 0.6 -0.3 1.1 1.0 0.8 0.9 0.4 0.8
Diabetes diagnosed by doctor 0.8 1.4 2.7 -1.4 1.2 -1.3 -1.2 -0.8 -0.5 -0.7 -1.2 -1.3 1.3 -1.6 -0.9 -1.5 -0.6 -1.2 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.6 -0.1 0.5 -0.1 0.0 -0.8 -0.2 -0.0 0.2 0.1 0.1 -0.4 0.2 0.3 -0.2 -0.4 -0.3
Friendships satisfaction 0.5 0.6 2.6 -0.6 -1.1 -0.6 -0.3 -0.3 -1.6 -1.4 -0.8 -0.8 0.6 -0.3 -0.7 -0.6 -0.4 -0.3 -0.2
Qualifications: nursing, teaching 2.5 3.9 13.1 1.5 3.6 2.3 2.1 1.1 2.5 2.2 1.5 1.4 -1.4 2.5 1.6 2.3 1.2 1.0 1.5
Commuting to job workplace: Walk 0.9 1.0 4.8 -0.3 -2.2 -1.6 -0.9 -0.0 -1.9 -1.2 -0.1 -0.3 0.1 -0.4 -1.2 -0.9 -0.4 -0.5 -0.1
Eye problems/disorders: Cataract 1.1 1.3 3.2 -0.9 -1.8 -1.3 -1.6 -1.3 -1.3 -1.4 -0.7 -1.0 0.8 -0.9 -1.5 -1.2 -0.8 -0.2 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 3.5 -0.1 1.9 0.9 0.8 0.2 0.8 1.7 -0.1 0.3 0.1 -1.0 1.1 -0.2 0.9 -0.0 -0.3
Medication for cholesterol 0.3 0.5 1.7 0.9 0.6 0.5 0.5 0.4 1.3 0.4 0.6 0.7 -0.7 -0.2 1.1 0.7 0.7 0.6 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 3.4 -1.7 0.1 -1.4 -1.1 -1.8 -1.2 -1.1 -1.7 -1.4 1.7 -1.1 -1.1 -0.5 -1.7 -1.9 -1.5
Back pain experienced in last month 1.1 1.6 3.6 -1.6 1.9 -0.4 -0.1 -0.6 0.5 -1.1 -1.9 -1.4 1.7 -1.4 -0.1 -1.3 -0.5 -1.6 -1.4
Mineral and other dietary supplements 0.5 0.7 1.4 -0.9 -0.2 -1.0 -1.1 -1.0 -0.9 -0.2 -1.2 -1.2 0.9 -1.1 -0.9 -0.7 -0.3 0.3 -0.2
Breast cancer (self-reported) 4.5 5.4 8.8 2.8 2.2 2.2 2.4 2.3 2.3 1.6 3.0 2.6 -2.7 2.7 1.6 2.3 2.1 1.0 2.3
Asthma (self-reported) 2.7 5.5 11.2 -2.5 -1.0 -2.2 -2.2 -3.0 -0.5 -2.3 -2.2 -2.2 2.6 -2.9 -1.7 -1.7 -2.8 -2.6 -3.3
Osteoporosis (self-reported) 2.4 3.0 5.7 -1.9 -1.0 -1.7 -2.0 -1.9 -0.9 -2.4 -1.7 -2.0 1.9 -1.3 -2.1 -1.4 -1.8 -1.6 -1.5
Osteoarthritis (self-reported) 3.4 4.4 11.8 -3.2 -0.5 -1.7 -1.3 -1.8 -1.5 -1.5 -3.4 -2.9 3.2 -1.7 -1.3 -1.2 -2.3 -1.2 -2.2
Medication: Aspirin 0.9 1.1 3.6 -1.8 -0.6 -0.7 -0.5 -0.4 -0.9 0.2 -1.9 -1.6 1.8 -0.7 -0.2 0.1 -1.1 -0.2 -1.3
Medication: Gliclazide 0.4 0.4 2.4 0.4 -0.3 -1.1 -0.5 -0.0 -1.2 -1.6 0.5 0.2 -0.5 0.1 -0.5 -0.5 0.4 0.0 0.4
Illnesses of father: None of the above (group 1) 0.6 0.7 2.5 0.5 0.8 1.3 1.1 0.1 1.6 0.6 0.5 0.8 -0.3 -0.6 1.4 1.1 0.6 -0.0 -0.3
Smoking status: Current 0.3 0.5 1.9 0.3 -1.1 -0.8 0.3 0.8 -1.4 -0.4 0.7 0.5 -0.6 0.2 -0.2 -1.2 0.8 -0.0 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 3.8 -0.3 -0.6 0.0 0.7 -0.4 -0.5 -1.0 -0.4 0.0 0.3 -0.2 0.2 -1.4 -0.1 -1.9 -1.0
Whole body water mass 0.2 1.2 3.8 -1.4 1.6 -1.9 -0.2 -0.4 -0.8 -0.3 -1.3 -1.0 1.2 -1.1 -0.8 -1.3 -0.2 -1.2 -0.4
Leg predicted mass (right) 0.2 1.3 4.5 -1.5 1.0 -2.1 -0.4 -0.6 -1.1 -0.6 -1.5 -1.2 1.2 -0.9 -1.2 -1.6 -0.2 -1.1 -0.2
Arm fat mass (left) 2.4 10.0 17.5 -4.1 -0.7 -4.0 -3.1 -2.8 -2.5 -2.3 -4.2 -4.2 3.9 -3.3 -3.6 -3.3 -2.6 -1.7 -2.0
Number of self-reported non-cancer illnesses 6.7 11.6 18.6 -4.2 -0.6 -3.6 -3.6 -3.3 -2.8 -3.3 -4.1 -4.0 4.1 -4.3 -3.1 -2.8 -3.1 -2.4 -3.3
Average weekly champagne plus white wine intake 0.0 0.1 0.1 -0.3 -0.0 -0.0 0.3 -0.2 0.4 -0.3 -0.2 -0.1 0.4 0.1 0.1 -0.0 -0.3 -0.3 -0.2
Miserableness 0.2 0.4 1.6 -0.2 -0.3 -1.1 -0.1 0.4 -0.9 -1.2 0.0 0.1 0.0 -0.9 -0.1 -1.3 0.8 0.1 0.3
Guilty feelings 1.1 1.7 3.9 -1.6 -1.6 -1.5 -1.1 -0.5 -0.9 -0.6 -1.4 -1.2 1.5 -1.7 -0.4 -1.4 -0.9 -0.9 -2.0
Wears glasses or contact lenses 0.4 0.4 1.7 -0.3 -1.0 -0.7 -0.2 0.4 -1.3 -0.8 -0.4 -0.3 0.1 1.0 -0.7 -0.2 0.1 0.2 1.0
Ever taken oral contraceptive pill 0.4 0.4 1.1 -0.3 0.4 -0.4 -0.9 -0.9 -0.5 -0.4 -0.2 -0.4 0.3 -1.0 -0.5 -0.1 -0.9 -0.8 -1.0
Hearing aid user 0.5 0.6 2.7 0.1 1.6 0.2 0.5 0.9 -0.0 0.7 0.2 -0.0 -0.2 1.2 -0.3 0.1 0.6 0.8 1.6
Mother’s age at death 1.1 1.4 3.4 -1.6 1.3 -0.4 -0.5 -0.8 -0.1 -1.2 -1.5 -1.2 1.7 -1.1 -0.3 -0.4 -1.4 -1.4 -1.8
Financial situation satisfaction 2.0 2.5 6.1 -1.2 -1.2 -1.7 -1.3 -2.5 -1.8 -1.5 -1.1 -1.0 1.1 -1.7 -1.4 -1.4 -1.6 -2.3 -1.8
Tinnitus: Yes, now most or all of the time 3.1 3.6 5.6 2.3 1.4 2.1 1.8 2.2 1.1 2.2 2.0 2.1 -2.3 1.7 1.7 0.8 2.4 1.5 1.8
Commuting to job workplace: Public transport 0.8 0.9 2.6 0.7 0.7 0.9 1.2 1.2 -0.3 1.6 0.8 0.9 -0.8 0.2 1.1 -0.2 1.6 0.8 0.9
Eye problems/disorders: Glaucoma 0.8 1.0 2.1 -1.2 -0.9 -0.8 -0.7 -1.0 -0.2 -1.3 -1.5 -1.2 1.3 -0.7 -0.8 0.1 -1.3 -0.6 -0.9
Medication: Blood pressure 1.3 2.4 5.5 -1.6 -1.1 -1.6 -1.3 -1.2 -2.3 -2.0 -1.4 -1.4 1.4 -1.4 -1.9 -2.2 -1.0 -1.3 -0.5
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.6 -0.8 -0.8 -0.8 0.0 0.3 -0.6 -0.4 -0.6 -0.4 0.7 -0.7 -0.2 -0.8 -0.2 -0.8 -0.7
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.6 0.3 -0.3 0.3 0.7 0.4 -0.0 -0.2 0.6 0.8 -0.3 0.2 0.5 0.3 -0.1 -0.5 -0.3
High cholesterol (Self-reported) 0.1 0.2 1.2 0.1 -0.9 0.1 -0.4 0.4 -0.2 0.3 -0.1 -0.2 -0.2 -0.4 -0.4 -1.1 0.9 -0.3 0.4
Medication: Bendroflumethiazide 0.1 0.2 1.6 -0.1 -0.4 -0.2 -0.3 -0.4 -0.2 1.3 0.3 0.1 0.1 -0.8 0.0 0.1 -0.4 -0.3 -0.6
Medication: Paracetamol 4.1 6.4 8.9 -2.9 -1.1 -2.7 -2.7 -2.9 -2.2 -2.3 -3.0 -3.0 2.8 -2.9 -2.7 -2.6 -2.3 -1.7 -2.0
Medication: Lisinopril 1.7 2.3 6.2 -1.3 -1.6 -2.1 -1.8 -1.0 -1.9 -1.4 -1.4 -1.6 1.2 -1.2 -2.0 -2.5 -0.6 -0.4 -0.3
Medication: Atorvastatin 0.3 0.4 2.9 -0.1 1.7 -0.3 -0.4 0.2 0.2 1.1 -0.2 -0.3 0.1 -0.2 -0.1 0.8 -0.2 0.7 0.2
Illnesses of father: High blood pressure 0.5 0.6 2.4 0.0 0.4 -1.0 -0.9 -0.5 -1.6 -0.8 0.1 -0.3 -0.2 0.2 -1.4 -1.2 -0.1 -0.6 0.5
Alcohol drinker status: Never 0.6 0.7 3.2 -0.9 0.3 -0.6 0.0 -0.6 -1.2 -0.1 -0.8 -0.4 0.9 -0.8 -0.0 -0.2 -0.9 -1.8 -1.5
Ever smoked 1.6 2.8 9.7 -1.7 -1.6 -1.6 -1.4 -1.7 -1.5 -1.7 -1.5 -1.8 1.5 -1.4 -2.1 -3.1 -0.5 -1.4 -0.7
Basal metabolic rate 0.4 2.4 6.9 -2.0 1.1 -2.6 -0.9 -1.0 -1.4 -0.9 -2.0 -1.7 1.8 -1.6 -1.5 -2.0 -0.7 -1.4 -0.7
Leg fat percentage (left) 3.0 10.7 19.2 -4.2 -1.0 -3.6 -3.3 -3.3 -1.9 -2.3 -4.3 -4.4 4.1 -3.7 -3.6 -3.7 -2.6 -1.6 -2.3
Arm fat-free mass (left) 0.2 1.2 4.0 -1.5 1.3 -2.0 -0.6 -0.4 -0.7 -0.2 -1.4 -1.3 1.3 -1.1 -1.2 -1.7 -0.1 -0.7 0.0
Number of operations (self-reported) 0.7 1.0 9.6 -0.4 -3.1 -1.0 -0.1 0.3 -1.4 -1.4 -0.2 -0.2 0.2 0.6 -0.7 -0.7 -0.4 -0.3 -0.1
Average weekly beer plus cider intake 0.3 0.4 1.1 0.6 -1.0 -0.4 -0.4 0.9 -0.8 0.2 0.6 0.4 -0.7 -0.3 -0.1 -1.0 1.0 0.5 0.6
Irritability 0.3 0.5 1.9 -0.7 0.3 -0.8 -0.6 -0.0 -1.4 -0.4 -0.6 -0.6 0.6 -0.8 -0.7 -1.2 0.3 0.6 0.6
Risk taking 0.1 0.2 2.1 0.2 1.4 0.2 0.2 -0.5 -0.0 0.2 0.3 0.1 -0.2 0.6 -0.3 0.2 0.1 -0.2 0.6
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.8 0.3 0.3 0.2 0.5 -0.5 0.2 0.5 0.1 0.3 -0.3 0.6 0.2 0.9 -0.3 -0.8 -0.0
Fractured/broken bones in last 5 years 1.5 1.9 3.4 1.4 0.8 1.3 1.8 1.0 1.6 1.5 1.6 1.7 -1.3 1.2 1.8 1.7 0.8 1.1 0.4
Age started oral contraceptive pill 0.5 0.6 4.9 -0.4 2.2 -0.1 -0.3 0.0 0.1 0.5 -0.5 -0.5 0.5 0.5 -0.7 1.1 -0.8 -0.5 0.3
Diastolic blood pressure, automated reading 2.0 6.1 11.6 -2.4 -2.8 -2.9 -2.7 -2.3 -3.4 -2.9 -2.2 -2.5 2.3 -2.9 -2.9 -2.7 -1.6 -0.5 -0.8
Ever depressed for a whole week 2.7 3.4 7.3 -1.8 0.3 -1.4 -1.3 -2.7 -1.2 -2.3 -1.7 -1.6 1.7 -2.5 -1.5 -2.3 -1.4 -2.2 -2.0
Unable to work because of sickness or disability 0.8 1.0 4.0 -0.4 -2.0 -1.1 -0.8 -0.5 -1.9 -0.9 -0.1 -0.5 0.2 -0.7 -1.0 -1.9 0.3 -0.0 0.1
Commuting to job workplace: Cycle 0.3 0.4 1.5 -0.5 -0.0 -0.6 -0.8 -1.0 -0.3 -0.7 -0.4 -0.4 0.5 -0.1 -0.4 0.8 -1.2 -0.2 -0.5
Myopia 1.0 1.4 4.0 1.5 0.5 1.2 1.1 0.4 2.0 0.4 1.5 1.3 -1.4 1.0 1.4 0.9 1.2 1.3 0.9
Vascular/heart problems diagnosed by doctor 2.2 6.0 11.9 3.0 1.4 3.2 2.6 1.5 3.5 1.9 2.8 3.0 -2.7 2.7 2.8 2.8 1.4 0.5 0.9
Cholesterol lowering medication 0.7 1.0 2.2 -1.4 -0.5 -1.1 -0.7 -0.6 -0.6 -1.0 -1.5 -1.4 1.3 -0.5 -1.2 -1.4 -0.6 -0.9 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.9 0.1 -0.1 -0.7 -1.4 -1.1 -0.4 -0.1 0.2 -0.4 -0.2 0.0 -1.3 -0.0 -0.2 0.2 0.6
Pain experienced in last month 0.3 0.6 1.3 0.8 -0.3 0.6 0.2 -0.1 -1.0 1.1 1.0 0.9 -0.9 0.8 -0.0 1.2 -0.1 0.7 0.9
Supplements: Calcium 0.3 0.3 1.5 -0.0 -1.2 -0.6 -0.7 -0.3 -0.9 -0.4 0.5 0.0 -0.0 -0.4 -0.1 -0.4 -0.4 0.2 -0.5
Basal cell carcinoma (self-reported) 0.2 0.3 1.0 -0.4 0.8 0.4 0.2 -1.0 0.7 -0.8 0.0 -0.3 0.5 -0.4 -0.2 0.2 -0.4 -0.6 -0.4
Heart attack/myocardial infarction (self-reported) 1.9 2.4 5.4 -1.9 -0.7 -1.6 -1.3 -1.1 -1.7 -1.3 -1.5 -1.5 1.8 -1.6 -1.1 -1.4 -1.9 -1.6 -2.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.3 1.1 0.5 0.2 0.3 0.7 -0.2 0.4 1.4 1.0 -1.2 0.9 0.1 0.9 0.9 1.1 1.5
Heart disease (siblings) 3.7 4.6 7.6 -2.8 -1.6 -1.9 -1.9 -1.4 -2.3 -1.5 -2.6 -2.5 2.6 -2.4 -2.0 -2.1 -1.9 -1.8 -2.3
Alcohol drinker status: Previous 1.5 1.7 3.5 -1.3 -0.7 -1.6 -1.8 -1.4 -1.0 -1.9 -1.6 -1.7 1.2 -0.6 -1.9 -1.3 -0.8 -0.6 -0.1
Pack years of smoking 4.3 6.2 10.0 -2.7 -0.0 -2.6 -2.4 -2.2 -1.8 -2.6 -2.5 -2.5 2.7 -2.9 -2.2 -2.3 -2.8 -3.0 -3.2
Impedance of whole body 0.3 1.3 11.5 0.9 -3.4 -0.0 -0.5 -0.1 -2.1 -1.0 1.1 0.7 -1.0 0.5 -0.3 -0.4 0.0 0.0 0.3
Leg fat mass (left) 2.6 10.1 17.9 -4.1 -0.6 -4.0 -3.2 -3.0 -2.0 -2.4 -4.2 -4.2 3.9 -3.4 -3.6 -3.6 -2.4 -1.5 -1.9
Arm predicted mass (left) 0.3 1.3 4.6 -1.5 1.3 -2.1 -0.6 -0.5 -0.7 -0.3 -1.4 -1.3 1.3 -1.0 -1.3 -1.7 -0.2 -0.8 -0.1