TWAS hub - VPS13B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.119	0.0480	7.7e-04	0.032	NA	0.039	NA	0.040	1.2e-03	NA	3.4e-04	NA	2.9e-04
2	GTEx	Artery Aorta	0.065	0.0320	2.2e-03	0.031	NA	0.041	NA	0.024	7.5e-03	NA	2.5e-03	NA	1.6e-02
3	GTEx	Artery Tibial	0.209	0.0727	3.9e-06	0.089	NA	0.071	NA	0.069	1.8e-07	NA	3.1e-06	NA	4.1e-06
4	GTEx	Brain Cerebellum	0.247	0.1070	7.2e-03	0.151	NA	0.182	NA	0.206	3.2e-05	NA	4.6e-06	NA	9.8e-07
5	GTEx	Brain Hypothalamus	0.271	0.1090	7.9e-03	-0.011	NA	-0.007	NA	-0.010	7.2e-01	NA	5.2e-01	NA	6.3e-01
6	GTEx	Esophagus Muscularis	0.120	0.0510	1.0e-03	0.075	NA	0.042	NA	0.061	2.5e-05	NA	1.4e-03	NA	1.4e-04
7	GTEx	Nerve Tibial	0.164	0.0541	6.0e-05	0.080	NA	0.074	NA	0.115	2.5e-06	NA	6.1e-06	NA	1.6e-08
8	GTEx	Skin Not Sun Exposed Suprapubic	0.137	0.0640	7.5e-03	0.041	NA	0.043	NA	0.042	2.5e-03	NA	2.1e-03	NA	2.5e-03
9	GTEx	Spleen	0.313	0.1270	6.9e-03	0.208	NA	0.165	NA	0.197	4.8e-06	NA	5.0e-05	NA	9.0e-06
10	GTEx	Testis	0.188	0.0820	1.2e-03	0.044	NA	0.070	NA	0.067	4.9e-03	NA	5.0e-04	NA	6.5e-04
11	GTEx	Thyroid	0.080	0.0350	4.3e-03	0.083	NA	0.059	NA	0.073	6.7e-07	NA	2.8e-05	NA	2.9e-06
12	ROSMAP	Brain Pre-frontal Cortex	0.102	0.0394	4.0e-04	0.037	0.030	0.035	0.035	0.044	1.2e-05	8.3e-05	2.3e-05	2e-05	2.3e-06
13	TCGA	Glioblastoma Multiforme	0.330	0.1270	6.2e-03	0.023	0.055	0.114	NA	0.089	6.8e-02	9.1e-03	2.5e-04	NA	1.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Schizophrenia vs Biploar Disorder	3.6	4.7	7.7	2.0	2.2	2.6	2.8	2.2	2.5	2.0	2.1	1.3	-0.0	2.3	2.4	2.4
Happiness	3.4	4.2	6.9	2.5	1.2	1.5	2.4	2.3	2.4	2.3	2.1	2.1	-0.1	2.6	2.3	1.3
Time employed in main current job	3.2	3.7	11.0	1.9	0.1	1.8	1.9	1.2	1.9	1.6	1.8	1.6	3.3	2.0	2.0	2.1
LDL Cholesterol	2.8	4.5	10.1	-3.2	0.8	-2.0	-1.7	-0.5	-2.1	-2.5	-2.0	-1.0	-2.7	-1.8	-2.3	-3.1
Type 2 Diabetes (T2D) (2018)	2.6	4.9	9.5	2.3	2.1	3.1	2.2	1.9	2.4	2.2	2.4	1.1	2.0	2.6	2.0	2.0
Ever taken oral contraceptive pill	2.5	2.7	4.9	-1.7	0.2	-1.3	-1.9	-0.5	-2.2	-2.0	-2.1	-0.9	-2.1	-2.0	-1.2	-1.8
Ever depressed for a whole week	2.4	3.0	4.4	-1.9	-1.1	-2.0	-2.0	-0.9	-2.0	-1.9	-1.8	-0.9	-2.1	-1.6	-1.9	-1.7
Alcohol usually taken with meals	2.3	3.8	7.3	-2.7	-1.1	-2.4	-2.1	-1.1	-2.2	-2.2	-2.3	-0.3	-1.6	-2.1	-1.9	-1.9
Medication: Omeprazole	2.3	2.8	6.2	-2.3	-0.2	-1.5	-1.6	-0.1	-1.5	-2.2	-1.9	-0.7	-2.5	-1.5	-1.3	-2.1
Ever had hysterectomy (womb removed)	2.2	2.5	6.4	1.8	0.7	2.2	1.9	0.3	1.1	1.1	1.7	-1.1	1.0	1.1	2.5	2.3
Had other major operations	2.2	2.6	6.0	-1.8	-0.8	-1.3	-1.8	0.4	-1.9	-2.0	-1.9	-0.8	-0.5	-1.9	-1.9	-2.5
Supplements: Zinc	2.0	2.2	4.8	-1.5	-1.2	-1.9	-2.2	0.8	-1.8	-1.3	-1.8	0.2	-0.3	-1.6	-1.4	-1.6
Medication: Ramipril	2.0	2.5	5.0	1.4	1.2	1.5	1.9	1.6	2.2	1.8	1.8	1.6	-0.1	2.0	0.7	1.5
Birth weight of first child	2.0	3.7	13.6	-1.7	1.5	-1.0	-1.0	-2.3	-1.9	-2.0	-1.6	-2.0	-3.7	-1.8	-1.7	-1.4
Glaucoma (self-reported)	2.0	2.4	4.8	1.2	0.6	1.5	2.2	1.7	1.4	1.3	1.4	1.3	-0.2	1.6	2.0	2.1
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	5.4	2.3	0.4	1.6	1.2	-0.3	1.7	1.9	1.8	0.7	-0.4	1.6	1.8	2.3
Pulse wave peak to peak time	2.0	2.4	4.6	1.9	0.3	1.5	1.5	-0.4	1.3	1.8	1.8	0.3	1.9	1.5	1.9	2.1
Average weekly spirits intake	1.9	2.4	4.4	2.1	0.3	0.8	1.3	1.5	1.8	1.9	1.7	1.5	0.2	1.9	2.0	1.5
Prospective memory result	1.9	2.3	4.3	1.4	0.4	1.2	1.5	-0.1	1.8	1.7	1.8	0.5	2.1	1.8	1.9	1.7
Number of full brothers	1.9	2.4	4.5	-1.8	-0.4	-1.1	-2.0	-2.0	-1.3	-1.4	-1.1	-2.1	-1.1	-1.6	-1.8	-1.6
Osteoporosis (self-reported)	1.9	2.4	3.6	-1.8	-1.7	-1.8	-1.8	-0.7	-1.7	-1.6	-1.8	-1.0	0.1	-1.9	-1.7	-1.5
Heel T-Score	1.8	14.6	32.1	-3.3	-2.8	-5.2	-4.1	-2.5	-4.3	-2.8	-5.7	4.9	-1.8	-3.7	-3.8	-2.8
Medication: Ibuprofen	1.8	2.2	6.3	-1.3	-1.3	-1.7	-1.5	-2.5	-1.5	-1.6	-1.2	-1.3	-1.2	-1.2	-1.0	-1.3
Family relationship satisfaction	1.8	2.2	4.5	1.6	1.9	0.9	0.6	2.1	1.6	1.9	1.4	1.6	0.6	1.6	1.6	1.0
Hearing aid user	1.8	2.0	3.6	-1.9	-1.8	-1.5	-0.8	-0.4	-1.8	-1.6	-1.7	0.3	0.6	-1.3	-1.8	-1.5
Primary Biliary Cirrhosis	1.7	2.4	5.0	1.5	1.8	1.2	1.1	1.9	1.6	1.6	1.1	2.2	0.6	1.5	2.1	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	9.1	-1.7	-2.7	-3.0	-1.7	0.4	-2.3	-1.2	-2.8	2.1	-1.2	-1.9	-1.7	-0.7
Leg pain on walking	1.7	2.1	3.9	-1.4	-1.9	-1.6	-2.0	0.1	-1.4	-1.4	-1.5	-1.0	-0.1	-1.6	-1.6	-1.8
Heart attack/myocardial infarction (self-reported)	1.7	2.2	6.0	0.9	0.7	0.7	1.1	2.2	1.5	1.6	1.3	2.4	0.6	1.8	1.7	1.3
Heart attack	1.6	2.1	5.8	0.9	0.5	0.6	1.2	1.9	1.6	1.5	1.3	2.4	0.7	1.9	1.6	1.3
Allergy	1.6	3.7	8.4	2.9	0.4	1.8	1.2	1.6	2.0	2.5	2.0	1.1	0.4	1.9	2.2	2.9
Pulse wave reflection index	1.6	2.0	3.1	-1.8	-1.5	-1.6	-1.7	0.3	-1.2	-1.4	-1.5	-1.2	-1.3	-1.5	-1.6	-1.4
Eye problems/disorders: Glaucoma	1.6	1.9	3.5	1.4	0.6	1.3	1.9	1.0	1.4	1.4	1.5	1.3	-0.2	1.7	1.7	1.7
Age started oral contraceptive pill	1.6	2.1	3.7	1.8	-0.9	1.0	1.7	0.2	1.4	1.6	1.7	0.2	1.7	1.5	1.5	1.9
Fasting Glucose	1.5	1.8	9.6	0.6	1.6	0.2	-0.2	2.8	0.7	1.1	0.3	3.1	-0.0	0.9	0.2	0.2
Medication: Lansoprazole	1.5	1.8	4.1	0.7	1.5	1.2	1.6	1.9	1.4	1.3	1.4	1.1	0.1	2.0	1.1	0.3
Pulse wave Arterial Stiffness index	1.5	1.8	4.3	-1.6	0.2	-1.3	-1.0	0.6	-0.9	-1.5	-1.5	0.1	-2.1	-1.1	-1.8	-1.9
Shortness of breath walking on level ground	1.5	1.8	3.6	0.9	1.1	1.1	1.1	1.0	1.7	1.4	1.4	1.5	1.8	1.9	1.6	0.3
Body Mass Index (BMI) (2010)	1.4	1.9	14.0	0.0	3.7	1.7	0.6	1.1	0.6	0.3	0.6	0.4	-1.7	0.7	1.3	0.8
Lupus	1.4	2.1	4.8	1.9	-0.2	1.5	2.2	-0.3	1.6	1.5	1.3	0.8	1.4	1.5	1.6	1.7
Qualifications: CSEs or equivalent	1.4	1.8	3.3	-1.2	-1.6	-0.8	-1.7	-1.8	-1.6	-1.3	-1.4	-1.6	-0.1	-1.8	-1.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	6.6	-1.2	-0.7	-1.2	-1.4	-2.6	-1.4	-1.3	-1.0	-1.7	-0.5	-1.2	-1.1	-1.1
Alzheimer’s Disease (in father)	1.3	1.4	4.0	1.6	-1.2	0.3	0.5	-0.2	1.0	1.4	1.3	0.3	2.0	1.0	1.7	1.2
Rheumatoid Arthritis	1.3	1.8	4.0	-1.2	0.8	-0.5	-1.1	-1.6	-1.6	-1.5	-1.7	-0.5	-0.7	-1.6	-2.0	-1.4
Vitamin and mineral supplements	1.3	1.8	3.9	1.3	0.7	1.8	1.6	0.6	2.0	1.4	1.9	-0.4	0.6	1.6	1.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.2	-1.4	-0.5	-1.8	-1.8	-0.0	-1.3	-1.5	-1.6	-0.1	-1.1	-1.4	-1.4	-1.7
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	7.1	1.7	-0.8	0.8	0.7	1.3	0.5	1.0	1.0	-0.4	0.9	0.7	1.4	2.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	7.8	-0.8	-2.4	-2.5	-1.7	0.8	-2.1	-0.6	-2.4	2.8	-0.8	-1.6	-0.9	0.0
Had menopause	1.3	1.6	6.8	1.4	-1.4	0.8	0.9	2.1	0.7	0.9	0.8	0.6	2.6	0.9	1.0	0.9
Birth weight	1.3	2.8	6.1	-1.7	-0.2	-1.0	-1.4	-1.2	-2.5	-1.9	-1.8	-2.1	-1.6	-2.4	-1.7	-1.0
Had major operations	1.3	1.5	2.8	-1.3	-0.5	-1.2	-1.4	-1.7	-1.6	-1.1	-1.1	-1.0	-1.2	-1.3	-1.3	-0.6
Supplements: Vitamin C	1.2	1.4	3.9	-0.8	-2.0	-1.6	-1.3	0.8	-1.0	-0.4	-1.4	1.4	1.0	-0.9	-1.1	-0.5
Friendships satisfaction	1.2	1.5	3.3	1.0	1.1	0.6	1.1	1.8	1.5	1.3	1.1	1.6	0.0	1.4	1.6	0.6
HDL Cholesterol	1.1	1.8	3.5	-1.9	-1.6	-1.4	-1.1	-0.4	-1.5	-1.4	-1.8	-0.0	0.2	-1.4	-1.7	-1.4
Ulcerative Colitis	1.1	1.6	4.2	1.7	-0.0	1.5	1.2	0.5	0.6	1.1	1.2	-0.4	1.2	1.0	1.9	2.0
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.4	-1.4	0.6	-1.4	-1.6	0.4	-1.0	-1.3	-1.3	0.2	-1.5	-0.9	-1.4	-1.8
Ever used hormone-replacement therapy (HRT)	1.1	1.4	6.2	1.6	-2.5	0.0	0.6	-0.4	0.3	1.1	0.5	0.3	2.3	0.4	0.7	1.2
Hair/balding pattern: Pattern 2	1.1	1.5	3.7	1.2	1.3	1.5	1.9	1.1	1.3	1.1	1.4	0.3	1.0	1.4	0.5	0.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.8	-1.6	0.6	-1.4	-0.7	0.7	-0.8	-1.0	-1.2	1.0	-1.9	-0.3	-1.1	-1.6
Diabetes (self-reported)	1.1	1.7	4.2	1.2	1.7	2.0	1.1	1.1	1.3	1.3	1.5	0.0	1.1	1.5	1.1	1.1
Medication: Simvastatin	1.1	1.6	4.2	2.0	0.2	1.5	1.0	-0.3	0.8	1.7	1.4	-0.0	0.5	1.1	1.6	2.0
Fluid intelligence score	1.1	2.3	5.8	-1.5	0.9	-1.1	-1.9	-1.1	-1.3	-1.6	-1.9	0.2	-2.4	-1.7	-1.6	-1.3
Length of working week for main job	1.1	1.2	5.3	-1.2	-0.1	-0.9	-0.6	-2.3	-0.7	-0.8	-0.9	0.5	-0.9	-0.6	-1.3	-1.6
Gout (self-reported)	1.1	1.4	6.5	1.0	-1.7	0.6	0.8	0.2	0.4	1.2	0.7	0.2	2.6	0.5	1.2	1.9
Heart disease (mother)	1.1	1.3	8.8	0.7	-1.8	0.9	0.7	-0.6	0.5	0.9	0.5	0.1	3.0	0.6	0.9	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.8	-0.9	-0.9	-1.1	-1.3	-1.2	-1.1	-1.1	-0.4	-1.1	-1.0	-0.9	-1.4	-1.7
Diabetes diagnosed by doctor	1.1	1.8	4.3	1.4	1.5	2.1	1.4	1.2	1.2	1.3	1.5	0.2	0.8	1.6	1.2	1.1
Tinnitus: Yes, now most or all of the time	1.1	1.3	5.9	0.7	0.0	0.4	1.0	-0.2	1.1	0.8	0.7	1.6	2.4	1.3	1.3	1.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	5.2	-1.4	-0.4	-1.1	-1.0	-0.3	-1.0	-1.5	-1.2	-0.8	-2.3	-0.9	-0.5	-1.1
Age at First Birth	1.0	1.5	2.7	-1.7	-0.9	-1.5	-1.1	0.2	-1.5	-1.2	-1.7	0.5	-1.2	-1.4	-1.2	-0.9
Schizophrenia (2014)	1.0	2.2	4.4	1.1	1.0	1.7	1.6	2.1	1.8	1.3	1.5	0.4	0.8	1.5	1.9	1.6
Waist Hip Ratio (WHR)	1.0	4.3	10.4	2.9	-0.1	1.5	1.7	1.3	1.7	3.0	1.6	2.6	1.1	2.0	2.0	3.2
High blood pressure (mother)	1.0	1.4	2.8	1.4	1.5	0.9	0.8	0.1	1.5	1.7	1.1	1.0	0.7	1.5	1.0	1.3
High blood pressure (siblings)	1.0	1.4	3.2	1.5	0.3	1.5	1.0	0.1	0.9	1.7	1.4	0.5	1.1	1.0	1.0	1.8
Suffer from ‘nerves’	1.0	1.6	3.6	0.7	1.3	1.1	1.0	1.1	1.4	1.4	1.0	1.4	1.9	1.4	1.3	1.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	7.1	-0.6	-1.7	0.0	-0.6	-2.7	-0.4	-0.3	0.4	-1.7	2.4	-0.3	0.0	-0.1
Medication: Blood pressure	1.0	2.0	10.1	1.7	-1.4	1.0	0.7	0.6	0.7	1.5	1.1	0.2	3.2	0.9	1.0	1.7
Medication: Atorvastatin	1.0	1.3	6.6	0.4	0.8	-0.2	-0.3	2.6	0.5	1.0	0.2	2.5	-0.8	0.9	0.5	0.4
Risk taking	1.0	1.5	4.1	0.8	1.2	1.5	1.1	0.4	1.2	1.2	1.5	-0.6	0.7	1.2	1.5	2.0
Cholesterol lowering medication	1.0	1.5	3.4	1.8	0.5	1.2	1.2	0.2	0.9	1.7	1.4	0.5	0.9	1.3	1.2	1.6
Triglycerides	0.9	1.5	6.5	0.7	2.5	0.7	0.3	1.7	1.0	0.8	0.5	1.8	-0.9	1.1	1.3	0.8
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	8.1	-0.3	-0.6	-0.8	-0.2	0.9	0.2	0.3	-0.4	2.8	-0.8	0.7	-0.3	-1.1
Hearing difficulty/problems with background noise	0.9	1.5	5.5	-0.6	-2.3	-2.1	-1.5	-1.1	-0.9	-0.3	-1.2	1.3	-0.1	-0.7	-0.6	-0.9
Number of live births	0.9	1.3	4.9	1.2	-1.9	0.0	0.0	0.1	-0.1	1.0	0.2	-0.4	2.2	-0.2	1.2	2.1
Mouth/teeth dental problems: Dentures	0.9	1.6	6.6	0.2	0.8	0.2	1.2	2.2	1.2	0.8	0.8	2.6	-0.3	1.6	1.3	0.5
Mean time to correctly identify matches	0.9	1.7	4.3	1.3	0.8	1.1	1.4	2.1	1.4	1.2	1.1	1.7	0.5	1.1	1.0	1.3
Long-standing illness, disability or infirmity	0.9	1.4	3.3	-1.8	-1.1	-1.2	-1.4	0.1	-1.2	-1.5	-1.5	-0.2	0.8	-1.1	-1.3	-1.1
Medication: Aspirin	0.9	1.1	2.4	1.5	0.2	1.2	0.9	0.5	0.6	1.1	1.1	-0.1	1.5	0.7	1.4	1.5
Guilty feelings	0.9	1.3	4.0	-0.0	2.0	0.0	0.5	1.3	1.3	0.5	0.8	1.9	-1.4	1.5	0.2	-0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.2	9.7	0.6	-1.0	-0.1	0.8	3.1	0.4	0.6	0.1	0.8	0.6	0.4	0.7	1.3
Medication: Co-codamol	0.8	0.9	7.0	-0.1	2.6	1.2	0.5	1.0	0.7	0.3	0.5	0.2	0.5	0.7	0.5	-0.3
Hayfever, allergic rhinitis or eczema	0.8	1.7	5.0	-1.8	-0.3	-1.3	-0.5	-1.3	-1.3	-1.7	-1.2	-0.6	-0.5	-1.1	-1.6	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.2	-0.8	-1.8	-1.0	-1.1	1.2	-0.7	-0.6	-1.0	0.3	1.4	-0.7	-0.9	-0.7
Medication: Seretide 50 evohaler	0.8	0.9	2.0	-1.3	-1.4	-1.1	-0.8	0.5	-1.0	-1.1	-0.8	-0.9	0.5	-0.9	-0.8	-1.2
Number of full sisters	0.8	1.0	5.2	-0.5	-0.1	-0.0	-1.0	-2.3	-0.5	-0.6	-0.1	-1.6	1.2	-0.8	-0.5	-0.9
High cholesterol (Self-reported)	0.8	1.3	4.2	1.9	0.7	1.3	0.5	0.8	0.7	1.5	1.1	0.5	0.0	1.0	1.1	2.1
Number of operations (self-reported)	0.8	1.2	4.3	-0.9	-2.1	-1.3	-0.8	-0.1	-1.4	-0.9	-1.0	-1.0	0.1	-1.3	-1.1	-0.8
Basal cell carcinoma (self-reported)	0.8	1.0	3.2	-1.8	-0.2	-0.7	-0.5	-0.8	-0.8	-1.4	-0.7	-1.3	-1.1	-0.6	-0.6	-0.9
Pack years of smoking	0.8	1.2	3.4	1.0	1.7	1.8	0.7	0.1	1.3	1.1	1.1	0.5	0.8	1.1	0.9	0.9
Crohns Disease (2017)	0.7	1.5	7.9	-0.6	-2.8	-0.6	-1.0	-0.5	-1.1	-0.9	-0.6	-1.9	1.1	-1.2	-0.6	-0.1
HbA1C	0.7	0.8	2.8	-1.2	0.1	0.1	-0.6	0.2	-1.1	-1.2	-0.6	-1.7	-0.2	-0.9	-0.6	-1.4
Blood Red Count	0.7	6.4	44.5	-1.3	0.6	0.5	-1.5	-3.1	-2.0	-2.7	-0.8	-6.7	-0.2	-2.5	-1.6	-1.7
Hypothyroidism (self reported)	0.7	1.7	7.3	1.7	0.4	0.5	0.3	0.0	1.3	1.6	0.5	2.7	1.4	1.2	1.1	1.4
Hearing difficulty/problems: Yes	0.7	1.1	7.1	-0.5	-2.7	-1.8	-0.4	0.6	0.1	-0.1	-0.4	1.5	1.0	0.3	-0.2	-0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.9	0.2	1.7	1.2	0.9	0.3	1.0	0.6	0.7	0.3	-1.0	1.0	0.7	0.4
Fed-up feelings	0.7	1.4	2.7	-1.3	-1.5	-1.5	-1.3	0.5	-1.3	-1.0	-1.6	0.4	0.5	-1.1	-0.9	-1.2
Number of incorrect matches in round	0.7	1.1	6.9	0.9	-1.3	1.1	0.9	0.4	0.3	1.0	0.9	-0.7	2.6	0.5	0.6	0.0
Hair/balding pattern: Pattern 3	0.7	1.1	4.0	-0.1	-1.2	0.5	-0.3	-1.9	-0.4	-0.4	0.1	-1.9	2.0	-0.5	0.2	0.1
Medication: Amlodipine	0.7	1.0	4.5	1.0	-1.4	0.5	0.2	0.7	0.1	0.9	0.4	0.3	1.3	0.4	1.3	2.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.4	0.6	0.3	1.0	1.1	0.0	0.7	1.1	1.0	0.9	1.8	1.1	0.8	0.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	4.0	0.9	-0.7	0.7	-0.3	-0.9	-0.3	0.2	0.3	-2.0	1.3	-0.4	0.9	0.9
Health satisfaction	0.7	0.9	1.9	-1.4	-0.8	-1.4	-0.7	-0.2	-0.8	-1.0	-1.3	0.2	0.1	-0.9	-1.2	-1.2
Comparative height size at age 10	0.7	4.1	16.6	1.3	4.1	2.2	2.4	0.3	2.1	1.6	1.6	2.2	-0.6	2.3	1.5	1.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	4.1	1.1	0.4	-0.1	0.8	2.0	0.6	0.8	0.4	1.2	-1.2	0.7	0.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.4	0.9	-1.5	0.1	0.9	-0.3	0.6	1.0	0.5	1.6	0.4	1.0	1.2	0.9
Qualifications: nursing, teaching	0.7	1.1	2.4	0.5	1.6	1.2	1.0	1.5	1.3	0.6	1.2	0.7	0.2	1.4	0.9	0.4
Medication for cholesterol	0.7	1.0	5.8	-1.0	2.0	-0.2	-0.1	0.3	0.3	-1.0	-0.4	0.2	-2.4	-0.2	0.1	-1.1
Financial situation satisfaction	0.7	0.9	2.2	0.7	0.4	0.5	0.8	1.4	1.1	1.4	0.9	1.5	-0.1	1.2	0.9	0.5
Commuting to job workplace: Public transport	0.7	0.9	4.3	-0.0	2.1	1.0	0.6	-0.1	0.7	0.6	0.1	2.0	0.1	0.5	-0.4	0.7
Medication: Bendroflumethiazide	0.7	1.1	5.1	1.1	-1.5	0.3	0.5	-0.6	0.0	1.0	0.4	0.9	2.3	0.5	1.0	1.5
Medication: Lisinopril	0.7	0.8	2.2	-0.6	0.7	-0.7	-1.3	-0.8	-1.5	-0.8	-1.1	-0.8	-0.8	-1.0	-0.8	-0.5
Pain experienced in last month	0.7	1.2	2.9	1.2	1.1	1.7	1.3	0.6	1.0	1.0	1.3	0.2	1.2	1.1	1.4	0.5
Alcohol drinker status: Previous	0.7	0.8	2.7	-0.5	-1.6	-0.8	-1.0	-0.7	-0.9	-0.6	-1.0	-0.7	0.5	-1.0	-1.0	-0.2
Schizophrenia (2018)	0.6	1.1	5.1	0.7	0.7	1.1	1.0	2.2	1.3	0.8	0.9	0.4	0.7	0.9	1.1	0.8
Ulcerative Colitis (UC)	0.6	1.1	4.0	1.3	0.1	1.1	0.6	0.4	0.5	0.9	0.9	-0.5	1.1	0.7	1.7	2.0
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.1	-1.3	0.2	-1.1	-1.8	-0.6	-1.3	-1.3	-1.8	0.4	-1.1	-1.6	-1.1	-0.6
Breast Cancer	0.6	1.4	3.7	1.4	1.0	1.7	1.9	-0.8	1.1	1.0	1.4	0.0	-0.4	1.3	1.0	0.7
Ovarian Cancer	0.6	0.8	1.9	-0.7	-1.1	-1.4	-0.7	-0.4	-0.8	-0.8	-1.2	0.8	-0.6	-0.7	-0.9	-0.9
Blood White Count	0.6	4.2	31.1	-1.2	-1.0	0.3	-1.9	-1.2	-2.1	-1.8	-0.7	-5.6	-0.9	-2.5	-0.8	-0.7
Diabetes (father)	0.6	0.7	1.6	0.9	0.5	1.3	0.8	0.9	0.8	0.8	1.0	-0.4	0.2	0.5	1.1	1.1
Pack years adult smoking proportion	0.6	1.0	2.9	0.8	1.7	1.7	0.4	-0.2	1.1	1.0	1.0	0.3	0.8	0.9	0.6	0.9
Serious illness, injury or assault to yourself	0.6	0.7	1.5	-1.0	0.1	-0.3	-0.2	0.8	-0.7	-1.1	-0.5	-1.1	-0.6	-0.9	-1.1	-1.2
Nervous feelings	0.6	1.2	3.2	1.0	-0.4	0.6	0.9	1.4	1.1	1.2	0.8	0.9	1.8	1.0	1.4	0.9
Financial difficulties in last 2 years	0.6	0.8	1.8	-0.6	-0.2	-1.3	-1.4	-1.0	-0.8	-0.6	-1.1	-0.2	-0.4	-1.1	-1.2	-0.8
Illnesses of siblings	0.6	0.8	2.7	-1.4	0.1	-1.2	0.1	0.7	0.4	-0.9	-0.7	1.2	-1.0	0.2	-0.2	-1.7
Father’s age at death	0.6	0.8	2.4	0.9	0.7	0.5	1.3	1.6	1.0	0.8	0.7	0.7	0.4	0.9	0.8	0.9
Falls in the last year	0.6	0.8	2.3	-1.1	-0.3	-0.6	-0.5	0.1	-1.2	-1.2	-1.0	-0.2	0.7	-0.8	-0.9	-1.5
Noisy workplace	0.6	0.8	1.8	1.3	0.1	0.9	1.1	1.1	0.8	0.6	1.1	-0.6	0.4	0.8	0.8	1.0
Wheeze or whistling in the chest in last year	0.6	1.1	10.7	-0.7	-1.5	-0.4	-0.2	-0.2	-0.2	-0.2	-0.4	-0.7	3.3	-0.5	0.2	-0.2
Medication: Allopurinol	0.6	0.9	3.9	0.3	-2.0	-0.4	-0.4	-1.3	-0.6	0.2	-0.3	-0.5	1.9	-0.6	0.4	0.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	-0.3	-1.1	-1.1	-1.2	-0.9	-0.9	-0.7	-1.0	-0.6	-0.6	-1.0	-0.5	0.2
Commuting to job workplace: Cycle	0.6	0.7	2.8	0.3	0.2	0.1	1.0	0.4	1.0	0.9	0.5	1.3	1.7	1.1	0.3	0.3
Depression (Nagel 2018)	0.5	0.7	1.6	-0.9	-0.1	-0.9	-0.7	1.1	-0.7	-0.9	-0.8	0.0	-0.8	-0.5	-1.0	-1.3
Worry (Nagel 2018)	0.5	1.1	1.8	1.1	0.6	1.3	1.2	0.9	1.1	1.2	1.0	0.4	0.9	1.1	1.2	1.2
Coronary Artery Disease (CAD)	0.5	0.6	2.9	-0.4	-0.7	-0.1	-0.6	-1.7	-0.3	-0.7	-0.3	-1.4	-0.6	-0.9	-0.4	-0.0
Crohns Disease (2012)	0.5	0.9	5.3	-0.1	-2.3	-0.1	-0.2	-0.6	-0.2	-0.3	0.3	-1.9	1.3	-0.2	-0.0	-0.0
Allergy or Eczema	0.5	1.2	3.3	-1.6	-0.0	-1.2	-0.4	-1.0	-1.2	-1.4	-1.1	0.2	-0.8	-0.8	-1.2	-1.8
Chronotype (morning person)	0.5	1.1	4.7	-1.2	2.2	0.8	-0.4	0.3	-0.4	-1.2	-0.2	-1.3	-0.2	-0.5	-1.2	-1.2
Severe depression (siblings)	0.5	0.5	2.6	-0.6	0.0	-0.1	-1.6	0.0	-0.8	-0.3	-0.5	-0.8	0.9	-1.0	-0.5	-0.6
High blood pressure	0.5	1.3	3.3	1.4	0.2	1.0	0.5	0.2	0.9	1.5	1.2	0.6	1.8	1.3	1.2	1.7
Multivitamins +/- minerals	0.5	0.7	1.5	-0.7	0.7	-0.7	-1.0	-0.8	-1.2	-0.7	-1.2	0.5	0.3	-0.9	-1.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.5	0.1	0.5	-0.1	-0.1	-1.9	0.2	-0.1	0.2	-0.7	1.7	-0.0	0.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.7	-0.6	0.7	-0.9	-1.6	-0.7	-0.5	-0.7	-0.8	-0.2	-1.7	-0.7	-0.9	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	3.8	0.3	1.9	0.5	-0.1	1.6	0.3	0.2	0.3	-0.3	-0.9	0.2	0.1	0.3
Blood clot in the leg (DVT)	0.5	0.6	1.5	-0.9	-0.1	-0.7	-1.2	-0.6	-0.8	-0.6	-1.0	0.0	-0.1	-1.0	-1.1	-0.8
Number of children fathered	0.5	0.6	1.7	-0.1	-1.3	-1.3	-0.6	-0.0	-1.0	-0.4	-1.1	-0.5	-0.1	-1.0	-0.7	-0.3
Eye problems/disorders: None of the above	0.5	0.5	2.8	-0.6	-0.3	-0.7	-0.8	-0.6	-0.3	-0.6	-0.5	-0.6	0.2	-0.6	-1.7	-0.9
Emphysema/chronic bronchitis	0.5	0.5	2.4	0.1	-0.5	0.9	-0.2	-0.9	-0.1	0.1	0.2	-1.5	1.0	-0.3	0.5	0.9
Age at last live birth	0.5	0.8	2.5	0.9	1.6	0.8	0.2	1.1	0.5	0.7	0.2	0.9	-1.0	0.3	0.8	1.3
Hypertension (Self-reported)	0.5	1.5	4.5	1.5	-0.2	0.9	0.4	0.3	1.0	1.5	1.2	0.8	2.1	1.2	1.2	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.9	-0.8	-0.1	-0.6	-0.0	0.4	-0.6	-1.0	-0.5	-0.7	-1.7	-0.4	-0.7	-1.1
Illnesses of father: Heart disease	0.5	0.7	5.8	-0.4	-0.6	-0.0	-0.5	-0.4	-0.6	-0.6	-0.0	-2.4	0.4	-0.7	-0.5	-0.8
Eye problems/disorders: Cataract	0.5	0.6	2.8	0.9	-0.2	0.4	0.5	0.4	0.7	0.8	0.4	0.9	0.8	0.5	1.7	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.5	-0.1	-1.2	-0.4	-0.6	-0.9	-0.3	-0.6	0.1	-1.4	1.6	-0.4	-0.4	-0.7
Mineral and other dietary supplements	0.5	0.7	5.6	-0.0	0.9	0.8	-0.2	-2.4	-0.1	-0.2	0.3	-1.3	0.2	-0.3	-0.3	-0.1
Irritability	0.5	0.9	2.3	0.3	1.5	1.0	1.5	1.4	1.3	0.7	0.8	0.2	-0.0	1.0	0.7	0.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.4	-1.5	0.0	-0.9	-0.6	-0.3	-0.8	-1.4	-1.3	-0.4	-1.8	-1.2	-1.4	-1.9
Neuroticism (Nagel 2018)	0.4	0.9	1.6	1.0	1.1	1.0	1.0	1.3	1.1	1.2	0.8	0.8	0.7	1.1	0.7	0.5
Reaction Time	0.4	0.8	4.1	-0.4	1.0	-0.5	0.2	1.3	-0.2	-0.5	-0.7	1.4	-2.0	-0.4	-0.8	-0.6
Neuroticism (2016)	0.4	0.6	2.2	-1.1	-0.2	-0.3	-0.4	-1.5	-0.5	-0.8	-0.7	0.0	0.1	-1.0	-1.1	-0.9
Diabetes (mother)	0.4	0.5	4.7	0.3	2.2	0.1	-0.1	-0.4	0.4	0.2	0.0	0.7	-0.7	0.2	-0.9	-0.2
Taking other prescription medications	0.4	0.6	1.9	-0.3	-1.4	-0.8	-1.2	-1.2	-0.7	-0.3	-0.6	-0.1	0.2	-0.7	-0.7	-0.1
Medication: Atenolol	0.4	0.5	1.4	1.2	-0.0	0.9	-0.1	0.4	0.5	1.0	1.0	-0.0	0.9	0.6	0.3	0.6
Medication: Levothyroxine sodium	0.4	0.7	6.0	0.0	1.4	-0.6	-0.8	-0.3	0.1	0.0	-0.7	2.5	-0.1	0.1	-0.2	0.1
Sitting height	0.4	2.8	18.0	-0.0	4.2	0.9	2.0	-0.2	1.3	0.4	0.4	2.8	-1.3	1.2	0.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	5.7	-0.3	0.8	-0.1	0.7	2.4	0.3	-0.1	-0.2	0.6	-0.6	0.3	-0.1	-0.4
Forced vital capacity (FVC)	0.4	1.4	5.7	0.1	2.4	0.5	1.1	0.9	1.0	0.4	0.2	2.3	-0.9	1.1	0.8	0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	0.7	-0.1	0.8	1.2	0.4	0.6	0.7	0.8	-0.2	1.3	0.9	0.3	-0.3
Worrier / anxious feelings	0.4	0.8	1.7	-1.3	-0.2	-0.9	-0.6	0.8	-0.8	-0.8	-1.1	0.2	-0.7	-0.9	-1.3	-1.2
Depression (self-reported)	0.4	0.5	2.0	-0.5	-0.7	-0.6	-1.4	0.2	-0.8	-0.6	-0.6	0.1	0.8	-0.6	-0.7	-0.3
Illnesses of mother	0.4	0.5	2.3	0.4	0.8	0.3	0.8	1.2	0.4	0.2	0.6	0.6	-1.5	0.4	0.5	-0.1
Standing height	0.4	3.7	16.6	0.4	4.1	0.8	2.2	0.6	1.6	1.1	0.8	3.7	-1.7	1.8	0.2	0.8
Hair/balding pattern: Pattern 4	0.4	1.0	4.2	0.0	0.6	0.6	0.6	1.3	1.0	0.6	0.4	2.0	1.4	0.9	1.1	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.0	-0.3	-0.2	-0.5	-1.2	-0.4	-1.1	-0.4	-0.7	-0.9	-1.4	-1.0	-0.7	-0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	4.9	0.5	0.5	0.1	0.1	-0.1	0.7	0.7	-0.0	2.2	1.3	0.7	0.3	0.5
Worry too long after embarrassment	0.4	0.6	1.2	-0.7	0.0	-0.0	-1.1	-0.8	-1.0	-0.9	-0.7	-1.1	-0.2	-1.0	-0.8	-0.6
Migraine (self-reported)	0.4	0.5	2.2	0.6	-0.2	0.0	0.9	0.3	0.9	1.0	0.6	1.5	-0.1	1.0	0.2	0.6
Pulse rate, automated reading	0.4	1.2	4.9	-0.5	2.2	0.2	-0.4	-1.0	-0.9	-1.0	-0.4	-0.8	-2.2	-0.6	-0.4	-1.0
Alcohol intake frequency.	0.4	1.0	6.0	-0.9	-0.0	-0.6	-0.9	-2.4	-0.8	-0.9	-0.9	-0.8	0.8	-0.7	-0.7	-1.0
Chest pain or discomfort	0.4	0.5	2.3	0.2	-1.5	-1.1	-1.0	-0.1	-0.4	0.3	-0.3	0.8	1.2	-0.1	0.3	0.1
Medication: Aspirin	0.4	0.5	1.8	1.2	-0.1	0.7	0.3	0.3	-0.0	0.7	0.5	-0.7	1.3	0.1	0.8	1.1
Illnesses of siblings: Diabetes	0.4	0.5	1.3	1.1	-0.1	0.9	-0.0	-0.2	-0.2	0.8	0.4	-1.1	0.7	-0.3	0.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	4.6	0.6	1.6	0.4	0.4	-0.2	0.7	0.6	0.3	0.8	-2.2	0.4	0.0	0.8
Average weekly red wine intake	0.4	0.6	3.3	-0.2	1.8	0.7	0.9	0.0	0.4	0.2	0.2	0.9	-1.6	0.4	-0.3	0.2
Back pain experienced in last month	0.4	0.6	0.9	-0.9	-0.4	-0.8	-1.0	0.2	-0.9	-0.9	-0.8	-0.9	-0.2	-0.9	-0.8	-0.7
Smoking status: Current	0.4	0.6	2.6	-0.1	-0.5	-0.2	-1.6	-0.8	-0.7	-0.2	-0.4	-1.4	0.1	-1.0	0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.7	1.0	-0.5	0.9	0.7	0.9	0.8	0.8	0.8	-0.8	-0.1	0.5	1.2	1.6
Supplements: Calcium	0.4	0.5	1.8	-0.1	-0.8	-1.1	-0.9	1.1	0.2	0.2	-0.2	1.4	0.0	0.3	-0.1	0.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.2	-0.8	-0.3	-0.7	-1.1	-0.7	-0.6	-0.5	-0.8	0.0	0.1	-0.8	-0.9	-0.6
Bipolar Disorder (2018)	0.3	0.5	4.0	-0.1	-0.7	-0.3	-0.5	-1.1	-0.3	-0.2	0.1	-0.6	2.0	-0.3	0.2	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.6	3.3	0.5	0.0	0.6	0.4	1.0	0.9	0.5	0.8	-0.0	1.8	0.5	1.0	0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	0.8	-0.8	-0.1	0.1	-0.2	0.5	0.6	0.5	-0.0	1.1	0.4	0.7	0.7
Irritable Bowel Disease (IBD)	0.3	0.8	2.7	0.6	-1.6	0.4	-0.1	-0.2	-0.3	0.1	0.2	-1.6	1.5	-0.2	0.7	1.2
Bipolar Disorder (2011)	0.3	0.3	0.8	-0.3	-0.8	-0.9	-0.5	-0.1	-0.7	-0.5	-0.6	0.1	-0.2	-0.5	-0.7	-0.6
Blood Platelet Count	0.3	3.9	27.9	-1.1	0.1	0.4	-2.1	-1.9	-1.6	-1.6	-0.5	-5.3	-1.2	-2.0	-1.3	-0.5
BMI	0.3	1.7	3.1	-1.0	-1.4	-1.2	-1.7	-0.7	-1.6	-1.2	-1.5	-1.2	-0.5	-1.7	-1.7	-0.5
Height	0.3	6.4	21.9	1.6	4.7	1.6	3.7	0.9	2.3	2.0	1.8	3.9	-0.5	2.9	1.2	1.7
Systolic Blood Pressure	0.3	1.3	7.4	-0.2	-2.7	-1.2	-1.7	-0.2	-1.3	-0.4	-0.9	-0.7	0.4	-1.2	-0.0	0.6
Smoking Status	0.3	0.7	2.5	-0.2	0.5	0.1	-1.4	-1.5	-0.7	-0.3	-0.2	-1.6	0.3	-0.8	-0.4	-0.6
Respiratory disease	0.3	0.7	3.1	-0.0	-0.1	0.7	1.3	0.2	0.8	0.5	0.9	-0.5	1.8	0.9	0.8	0.4
Lung FVC	0.3	1.7	5.0	0.7	1.6	0.7	1.0	1.5	1.6	1.1	0.7	2.2	-0.5	1.5	1.5	1.2
Number of treatments/medications taken	0.3	0.5	1.7	1.0	-1.3	-0.3	-0.3	0.4	-0.2	0.9	0.1	0.9	0.2	0.2	0.2	1.1
Systolic blood pressure, automated reading	0.3	0.9	5.6	0.9	-2.4	-0.8	-0.6	0.5	-0.4	0.7	-0.3	0.7	0.2	-0.2	1.0	1.5
Angina	0.3	0.3	2.6	-0.1	-0.3	-0.2	-0.4	-0.4	-0.1	-0.2	0.2	-1.0	1.6	-0.2	-0.5	-0.2
Medication: Metformin	0.3	0.5	1.1	0.6	0.9	1.1	0.6	0.6	0.5	0.7	0.7	0.1	0.6	0.8	0.7	0.6
Townsend deprivation index at recruitment	0.3	0.4	1.4	-0.8	0.1	-0.7	-1.2	-1.1	0.0	-0.4	-0.3	-0.1	0.5	-0.1	-0.6	-0.6
Current tobacco smoking	0.3	0.5	1.8	0.1	-0.3	0.0	-1.4	-1.0	-0.6	-0.0	-0.3	-1.2	0.5	-0.8	0.2	0.4
Average weekly fortified wine intake	0.3	0.3	1.1	-0.6	0.3	-0.2	0.2	1.0	-0.2	-0.4	-0.4	0.5	-0.5	-0.1	-0.8	-1.1
Stomach or abdominal pain in last month	0.3	0.3	2.7	-0.2	0.3	-0.0	-0.7	-0.2	-0.3	-0.3	-0.4	-0.5	-1.6	-0.3	0.1	0.1
Pain all over the body in last month	0.3	0.4	2.2	-0.6	0.1	-0.4	0.2	1.5	0.1	-0.4	-0.4	0.7	-0.3	0.0	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	4.6	0.1	1.7	0.2	0.7	0.5	0.6	0.4	-0.2	2.1	-1.0	0.6	0.7	1.1
Tense / ‘highly strung’	0.3	0.5	1.4	0.7	0.1	0.5	0.7	0.1	1.2	1.0	0.8	0.2	0.6	0.8	0.8	0.3
Peak expiratory flow (PEF)	0.3	0.6	4.1	-0.9	2.0	-0.0	-0.5	-0.8	-0.3	-0.7	-0.9	-0.2	-0.6	-0.5	-0.4	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	-0.6	1.0	-0.2	0.9	-0.4	0.2	-0.2	-0.2	1.1	-1.1	0.4	0.2	-0.2
Loud music exposure frequency	0.3	0.3	1.1	-0.7	-0.4	-0.6	-0.6	0.1	-0.5	-0.9	-0.4	-0.3	0.3	-0.4	-0.6	-1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.0	-1.0	0.2	-0.7	0.2	0.6	-0.3	-0.9	-0.7	0.2	-0.4	-0.5	-0.7	-1.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.3	0.5	0.8	0.5	0.1	0.7	0.8	0.7	0.6	1.1	-0.2	0.8	0.5	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.6	1.9	-1.4	-0.2	-0.4	0.4	1.3	0.0	-0.6	-0.6	1.1	-0.8	-0.3	-0.6	-0.8
Neck or shoulder pain in last month	0.3	0.4	1.1	-0.9	0.5	-0.8	-0.1	0.4	0.1	-0.2	-0.5	0.9	-0.8	-0.1	-1.0	-0.7
Angina (self-reported)	0.3	0.4	3.1	0.0	-0.5	-0.1	-0.4	-0.2	-0.1	-0.1	0.2	-0.9	1.8	-0.3	-0.4	-0.1
Ever had bowel cancer screening	0.3	0.4	1.9	0.6	-0.3	0.5	0.5	1.4	0.2	0.1	0.7	-1.0	0.3	0.4	0.4	-0.0
Commuting to job workplace: Walk	0.3	0.4	1.5	-1.1	0.7	0.2	-1.2	0.2	-0.2	-0.1	-0.3	-0.2	1.0	-0.3	0.2	0.4
Osteoarthritis (self-reported)	0.3	0.3	2.3	-0.1	-0.1	-0.4	0.3	-0.0	0.0	0.1	-0.2	1.2	-1.5	0.4	0.0	-0.1
Number of self-reported non-cancer illnesses	0.3	0.5	2.5	-0.3	-1.4	-0.5	-0.5	-0.2	-0.6	-0.3	-0.2	-0.6	1.6	-0.4	-0.2	0.1
Average weekly champagne plus white wine intake	0.3	0.4	2.7	0.6	0.1	0.4	0.2	1.6	0.6	0.4	0.7	0.2	-0.8	0.4	0.4	0.2
Miserableness	0.3	0.5	1.3	-0.6	1.0	-0.2	-0.3	-1.2	-0.5	-0.6	-0.5	-0.6	0.1	-0.5	-1.0	-1.0
Mother’s age at death	0.3	0.3	1.0	-0.9	-0.0	-0.3	-0.6	0.6	-0.7	-1.0	-0.6	-0.6	-0.2	-0.6	0.1	-0.3
Average weekly beer plus cider intake	0.3	0.4	1.8	0.8	-0.7	0.5	0.3	0.7	0.2	0.3	0.8	-1.4	0.5	0.1	0.6	0.7
Diastolic blood pressure, automated reading	0.3	0.8	2.7	1.3	-0.1	0.2	0.3	0.1	0.7	1.2	0.6	1.2	0.6	0.8	1.2	1.6
Heart disease (siblings)	0.3	0.3	2.2	0.4	-1.5	-0.2	-0.5	-0.1	-0.3	0.4	0.2	-0.3	0.5	-0.1	-0.1	0.9
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.7	-0.6	-0.1	-0.7	-1.3	-0.0	-0.5	-0.8	-1.1	0.3	-0.7	-1.0	-0.4	-0.1
Prostate Cancer	0.2	0.2	0.7	0.2	-0.7	0.1	0.8	0.0	0.8	0.6	0.5	0.5	-0.3	0.6	0.0	0.3
Lung FEV1/FVC ratio	0.2	0.8	3.3	0.2	-1.8	-0.6	-0.9	0.7	-1.2	0.0	-1.0	-0.2	-0.0	-1.3	-0.1	1.1
Hand grip strength (left)	0.2	0.4	1.7	0.3	0.2	0.6	0.9	-1.3	0.6	0.6	0.4	0.5	0.7	0.7	0.0	0.6
Sensitivity / hurt feelings	0.2	0.4	1.2	0.8	-0.5	0.4	0.4	-0.7	0.2	0.8	0.6	0.1	1.1	0.5	0.1	0.5
Impedance of leg (right)	0.2	1.1	3.1	0.7	0.2	0.7	1.2	1.7	1.2	0.9	1.0	1.2	-0.2	1.2	1.4	0.9
Leg fat-free mass (left)	0.2	0.8	6.1	-0.3	2.5	0.4	-0.2	-1.0	-0.3	-0.2	-0.3	0.4	-1.2	-0.2	-1.1	0.1
Maternal smoking around birth	0.2	0.3	1.1	0.0	0.5	0.2	0.7	1.0	0.7	0.1	0.5	0.9	0.1	0.8	-0.3	-0.4
Relative age voice broke	0.2	0.3	1.8	0.4	-0.2	-0.3	-0.3	0.6	-0.3	-0.0	-0.2	-0.8	-1.4	-0.6	0.4	0.6
Age when periods started (menarche)	0.2	0.6	1.6	0.1	0.7	0.2	1.1	1.3	1.1	0.6	0.9	0.7	0.0	1.0	0.0	-0.8
Impedance of leg (left)	0.2	1.0	4.2	0.4	-0.1	0.1	1.2	2.0	1.1	0.7	0.7	1.6	-0.6	1.2	0.7	0.2
Waist circumference	0.2	0.8	3.5	1.3	0.9	1.0	0.3	0.6	0.4	1.2	0.7	0.6	0.3	0.6	0.3	1.9
Trunk fat-free mass	0.2	1.3	9.5	-0.1	3.1	0.6	0.1	-1.5	0.0	0.2	-0.1	1.5	-1.6	0.3	-0.5	0.6
Alcohol intake versus 10 years previously	0.2	0.3	2.0	0.0	-1.4	-0.7	-0.4	0.2	-0.9	-0.0	-0.5	0.3	0.3	-0.4	-0.1	0.3
Pulse rate	0.2	0.3	1.0	-0.3	0.7	-0.2	-0.2	-1.0	-0.3	-0.5	-0.1	-0.2	-1.0	-0.2	-0.4	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.7	-0.1	1.6	1.0	-0.1	0.6	-0.3	0.1	-0.2	-0.3	-0.8	-0.2	-0.1	0.3
Asthma	0.2	0.4	3.1	-0.8	-0.1	-0.0	-0.0	-0.7	-0.2	-0.4	-0.0	-0.8	1.7	-0.2	0.2	-0.3
Medication: Cholesterol lowering	0.2	0.3	1.1	0.6	0.2	0.9	-0.5	-0.0	-0.1	0.5	0.5	-1.0	-0.0	0.1	0.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.7	-0.3	1.2	-0.3	0.3	0.8	0.0	-0.1	-0.7	1.4	-1.6	0.0	0.2	0.7
Trunk predicted mass	0.2	1.4	9.6	-0.1	3.1	0.5	0.2	-1.4	0.1	0.2	-0.1	1.5	-1.7	0.3	-0.5	0.5
Headache pain in last month	0.2	0.3	0.8	-0.6	-0.5	-0.8	-0.9	-0.4	-0.7	-0.3	-0.6	-0.2	-0.3	-0.3	-0.8	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.9	3.4	-0.3	1.8	0.1	0.6	1.1	0.4	-0.0	-0.3	1.8	-1.7	0.4	0.1	0.4
Arm fat-free mass (right)	0.2	1.1	8.5	-0.2	2.9	0.5	0.1	-0.5	0.1	0.1	-0.1	1.1	-1.6	0.3	-1.1	-0.0
Age at first live birth	0.2	0.4	1.9	-0.2	1.3	0.3	0.5	0.2	0.5	-0.0	-0.1	0.6	-1.4	0.2	0.0	0.3
Arm predicted mass (right)	0.2	1.2	9.2	-0.1	3.0	0.5	0.1	-0.5	0.0	0.1	-0.1	1.1	-1.7	0.2	-1.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.2	0.5	0.5	0.6	-0.4	-0.8	0.2	0.5	0.1	0.1	1.1	0.0	-0.2	0.3
Smoking status: Previous	0.2	0.4	0.8	0.4	0.8	0.8	0.5	0.3	0.7	0.3	0.9	-0.8	0.7	0.6	0.1	0.2
Whole body fat-free mass	0.2	1.2	8.6	-0.2	2.9	0.5	-0.1	-1.3	-0.2	0.0	-0.2	1.2	-1.5	0.1	-0.9	0.3
Leg fat-free mass (right)	0.2	1.0	5.9	-0.5	2.4	0.1	-0.2	-1.0	-0.4	-0.4	-0.4	0.6	-1.5	-0.2	-1.4	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	2.0	-0.2	-1.4	-0.8	-0.2	-0.0	-0.4	-0.0	-0.2	-0.1	0.3	-0.1	-0.1	-0.2
Loneliness, isolation	0.2	0.2	1.6	0.3	0.2	0.1	-0.0	-0.9	0.0	0.4	-0.2	1.2	0.1	0.1	0.3	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.0	-0.2	0.6	0.4	0.3	1.0	-0.0	0.1	-0.2	0.3	-1.0	-0.1	0.0	-0.0
Breast cancer (self-reported)	0.2	0.2	0.6	-0.2	-0.3	-0.2	-0.4	0.2	-0.5	-0.6	-0.3	-0.8	-0.1	-0.5	-0.2	-0.6
Asthma (self-reported)	0.2	0.3	2.1	-0.8	-0.2	-0.1	0.1	-0.4	-0.1	-0.4	0.0	-0.8	1.4	-0.2	0.2	-0.2
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.5	0.2	-0.4	-0.3	-0.7	-0.2	-0.4	-0.5	0.3	-0.3	-0.2	-1.0	-0.2
Whole body water mass	0.2	1.1	8.4	-0.2	2.9	0.4	-0.1	-1.3	-0.2	-0.1	-0.3	1.0	-1.6	0.0	-0.9	0.2
Leg predicted mass (right)	0.2	0.9	6.3	-0.5	2.5	0.2	-0.2	-0.9	-0.3	-0.3	-0.3	0.7	-1.5	-0.1	-1.3	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.4	-0.1	0.6	0.1	0.6	1.2	0.5	0.5	0.3	0.8	0.6	0.5	-0.2	0.2
Alcohol drinker status: Never	0.2	0.2	1.2	-0.4	0.5	0.0	-0.1	-0.9	-0.0	-0.3	-0.2	0.1	1.1	0.1	0.3	-0.3
Ever smoked	0.2	0.4	2.0	-0.1	1.2	0.4	-0.9	-0.5	-0.2	-0.2	-0.1	-1.4	-0.2	-0.6	-0.6	-0.1
Basal metabolic rate	0.2	1.0	7.5	-0.3	2.7	0.3	-0.2	-1.0	-0.3	-0.2	-0.3	0.8	-1.6	-0.1	-1.1	0.1
Arm fat-free mass (left)	0.2	0.9	6.7	0.0	2.6	0.4	0.0	-0.6	-0.0	0.1	-0.1	1.0	-1.4	0.2	-1.0	0.2
Unable to work because of sickness or disability	0.2	0.3	0.9	-0.0	-0.4	-0.5	-0.9	0.1	-0.8	-0.1	-0.8	0.3	0.8	-0.7	0.1	0.1
Impedance of whole body	0.2	1.0	5.4	0.3	-0.4	0.1	1.5	2.3	1.0	0.6	0.7	1.2	0.1	1.0	0.8	0.1
Arm predicted mass (left)	0.2	0.9	6.8	-0.1	2.6	0.4	-0.0	-0.4	0.0	0.1	-0.2	1.2	-1.5	0.2	-0.9	0.2
Depressed Affect (Nagel 2018)	0.1	0.3	1.5	0.1	1.2	0.1	0.1	0.7	0.3	0.1	-0.2	0.7	-0.8	0.3	-0.1	-0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.4	0.3	0.1	0.2	0.0	0.1	-0.5	0.0	-0.5	0.2	0.0	-0.4	-0.1
Major Depression (MDD)	0.1	0.2	0.6	0.2	0.6	0.1	0.8	0.6	0.1	0.2	0.4	0.2	-0.4	0.5	0.3	-0.3
Mean Putamen Volume	0.1	0.2	0.8	-0.1	0.9	0.2	0.6	0.1	0.3	0.2	0.3	-0.1	-0.2	0.5	-0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	0.1	0.1	-0.0	-0.2	-0.4	0.4	0.0	-0.1	-0.4	-0.2	-0.1	0.5
Blood Eosinophil Count	0.1	0.5	1.5	0.7	0.4	0.9	0.3	-0.5	1.2	0.8	1.1	-0.7	-0.0	0.8	0.3	0.4
Neuroticism	0.1	0.3	1.0	0.2	0.5	0.5	0.6	0.2	0.7	0.6	0.3	0.8	1.0	0.6	0.1	0.3
Hair Pigment	0.1	2.2	4.4	0.9	1.9	2.1	1.9	1.2	1.6	1.1	1.8	0.0	1.9	1.8	1.1	0.2
Tanning	0.1	0.7	2.9	-0.5	0.4	-0.5	-1.3	0.6	-0.7	-0.8	-0.6	-0.9	-1.7	-0.9	-0.3	-0.3
Relative age of first facial hair	0.1	0.3	2.8	0.0	0.7	-0.0	-0.2	0.5	-0.2	-0.2	-0.1	-0.4	-1.7	-0.1	-0.4	-0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.9	-0.6	0.5	-0.1	0.0	-0.1	0.2	-0.3	0.1	1.0	0.2	0.4	-0.3	-0.6
Medication for hormone replacement therapy	0.1	0.2	1.1	0.2	-1.1	-0.1	0.0	0.0	-0.2	0.0	0.2	-0.1	0.7	0.1	-0.4	0.1
Trunk fat percentage	0.1	0.2	1.4	0.2	0.1	0.3	0.0	1.2	0.0	0.1	0.3	-0.7	0.3	-0.0	-0.7	0.3
Hand grip strength (right)	0.1	0.4	1.5	0.6	0.8	0.7	0.8	-1.2	0.3	0.6	0.2	0.5	-0.5	0.3	0.4	0.7
Supplements: Glucosamine	0.1	0.2	0.5	-0.1	-0.7	-0.6	-0.3	-0.3	-0.1	0.1	-0.3	0.6	-0.2	0.0	-0.6	-0.3
Body mass index (BMI)	0.1	0.5	1.8	-0.1	-0.1	-0.1	-1.0	-0.5	-0.8	-0.4	-0.5	-1.3	0.1	-0.9	-1.1	0.2
Leg predicted mass (left)	0.1	0.8	6.0	-0.3	2.4	0.4	-0.2	-1.1	-0.3	-0.2	-0.2	0.3	-1.1	-0.2	-1.0	0.1
Past tobacco smoking	0.1	0.2	1.5	-0.1	-0.7	-0.4	0.2	-0.2	-0.3	0.0	-0.5	1.2	0.0	0.0	0.2	0.2
Qualifications: None of the above	0.1	0.3	1.2	0.5	-1.1	-0.7	0.0	0.5	-0.1	0.3	-0.2	0.6	0.3	0.2	0.8	0.6
Mouth/teeth dental problems	0.1	0.2	1.0	0.7	-0.5	0.2	0.1	-0.1	-0.6	-0.0	-0.3	-0.7	0.1	-0.6	0.1	1.0
Neuroticism score	0.1	0.2	1.3	-0.3	1.1	-0.0	-0.1	0.4	0.2	-0.0	-0.2	0.8	-0.2	0.1	-0.4	-0.7
Weight	0.1	0.4	3.8	0.1	2.0	0.4	0.0	-0.2	-0.0	0.1	-0.0	0.4	-0.6	0.0	-0.9	0.5
Impedance of arm (right)	0.1	0.5	1.5	0.1	-0.9	0.0	1.0	1.2	0.6	0.3	0.5	0.5	0.5	0.5	1.1	0.4
Arm fat percentage (right)	0.1	0.5	2.3	-0.2	-0.6	-0.1	-0.8	-0.1	-0.8	-0.5	-0.3	-1.5	0.3	-0.9	-0.8	0.1
Impedance of arm (left)	0.1	0.4	2.4	-0.1	-0.9	-0.1	1.1	1.6	0.5	0.1	0.5	0.1	0.2	0.4	0.6	-0.3
Arm fat mass (right)	0.1	0.3	1.3	-0.1	0.1	-0.1	-0.7	-0.4	-0.7	-0.4	-0.3	-1.1	-0.0	-0.7	-0.9	0.3
Exposure to tobacco smoke at home	0.1	0.2	0.7	0.4	-0.5	-0.1	0.1	0.9	0.4	0.1	0.2	0.3	0.4	0.3	0.6	-0.3
Breastfed as a baby	0.1	0.2	0.7	-0.3	0.3	-0.3	-0.2	0.1	-0.2	-0.5	-0.2	0.5	0.3	-0.3	-0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.1	0.2	0.4	-0.1	0.5	0.3	-0.2	0.1	-0.6	0.6	0.1	-0.3	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.7	0.0	0.8	0.1	0.3	0.4	0.6	0.2	0.3	-0.1	-0.6	0.1	-0.4	-0.4
Medication: Paracetamol	0.1	0.1	0.7	0.8	0.2	-0.5	-0.5	-0.3	-0.3	0.4	0.0	0.1	0.5	0.1	-0.1	0.3
Body fat percentage	0.1	0.2	1.3	0.3	-0.0	0.4	-0.0	1.1	-0.0	0.2	0.3	-0.8	0.5	-0.0	-0.6	0.5
Leg fat percentage (right)	0.1	0.3	1.3	0.7	0.0	0.7	-0.1	0.6	0.0	0.5	0.5	-0.7	0.6	0.2	0.0	1.1
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.3	0.2	0.2	0.4	0.5	-0.2	-0.1	-0.1	-0.3	0.2	-0.2	-0.6	-0.2
Comparative body size at age 10	0.1	0.3	1.4	0.4	1.2	0.6	-0.4	0.2	-0.1	0.3	0.4	-0.8	-0.8	0.1	-0.0	-0.1
Qualifications: College or University degree	0.1	0.4	1.1	0.4	0.3	0.8	0.2	-0.4	0.7	0.7	0.6	1.0	-0.0	0.7	1.1	0.5
Medication: Blood pressure	0.1	0.1	0.6	0.5	-0.1	0.4	-0.6	-0.5	-0.1	0.3	0.2	-0.0	0.2	0.1	0.2	0.8
Overall health rating	0.1	0.3	2.1	0.3	0.2	0.3	-0.0	0.1	0.3	0.5	0.3	0.1	1.5	0.3	0.1	0.6
Knee pain experienced in last month	0.1	0.2	1.0	-0.2	-0.4	-0.8	-0.5	-0.5	0.1	-0.1	-0.2	0.0	-1.0	0.0	-0.4	0.2
Arm fat percentage (left)	0.1	0.4	2.2	-0.1	-0.5	-0.1	-0.7	0.4	-0.7	-0.3	-0.2	-1.5	0.2	-0.7	-0.9	0.0
Mood swings	0.1	0.2	0.7	0.4	0.4	-0.5	-0.4	0.5	-0.1	0.1	-0.3	0.4	-0.8	-0.0	-0.4	-0.7
Medication: Gliclazide	0.1	0.2	0.6	0.6	0.1	0.4	0.0	0.2	-0.1	0.7	0.1	0.6	0.0	0.1	-0.5	0.5
Arm fat mass (left)	0.1	0.3	1.4	-0.1	0.2	-0.0	-0.6	-0.1	-0.7	-0.3	-0.3	-1.2	-0.2	-0.7	-1.1	0.1
Wears glasses or contact lenses	0.1	0.2	0.6	0.6	-0.2	0.1	-0.2	-0.3	-0.1	0.3	-0.0	-0.4	0.2	-0.2	0.8	0.7
Medication: Paracetamol	0.1	0.2	0.7	0.5	-0.4	-0.9	-0.7	-0.6	-0.5	0.0	-0.2	-0.0	-0.1	-0.1	0.2	0.2
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.5	0.1	0.1	0.3	-0.5	0.4	0.6	0.6	0.4	0.4	0.5	0.0	0.4
Fractured/broken bones in last 5 years	0.1	0.2	0.6	0.5	-0.3	0.3	0.0	0.8	-0.3	0.1	0.0	-0.5	0.8	-0.4	0.3	0.7
Myopia	0.1	0.2	0.7	-0.4	0.8	0.1	-0.1	-0.4	0.5	-0.4	0.3	-0.7	-0.6	0.2	-0.5	-0.6
Cardiovascular Disease	0.0	0.1	0.5	0.2	0.1	-0.3	-0.7	-0.4	-0.3	0.1	-0.2	0.5	0.1	-0.1	0.1	0.7
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.2	0.1	0.3	-0.1	0.1	-0.1	0.1	-0.1	0.4	0.2	-0.2	0.3	-0.0
Trunk fat mass	0.0	0.2	0.8	0.3	0.9	0.5	0.2	0.7	0.1	0.3	0.3	-0.2	0.1	0.1	-0.6	0.6
Hip circumference	0.0	0.2	0.9	-0.3	0.9	0.1	-0.1	0.6	-0.3	-0.3	-0.2	0.1	-0.6	-0.3	-1.0	0.1
Lung cancer (father)	0.0	0.0	0.2	0.1	0.2	0.4	-0.0	-0.1	-0.3	0.1	-0.1	0.0	0.2	-0.1	-0.1	-0.2
Whole body fat mass	0.0	0.1	0.5	0.3	0.7	0.4	-0.1	0.6	-0.1	0.2	0.1	-0.2	0.0	-0.0	-0.7	0.6
Leg fat mass (right)	0.0	0.2	0.6	0.3	0.6	0.4	-0.4	0.2	-0.4	0.1	0.0	-0.6	-0.1	-0.2	-0.5	0.8
Leg fat percentage (left)	0.0	0.2	0.6	0.4	-0.2	0.3	-0.2	0.7	-0.1	0.4	0.3	-0.4	0.4	0.1	-0.4	0.8
Leg fat mass (left)	0.0	0.1	0.5	0.1	0.6	0.2	-0.3	0.2	-0.4	0.0	-0.0	-0.4	-0.2	-0.2	-0.7	0.5

Hub : Genes

VPS13B

Models

Trait associations