Hub : Genes

VPS37A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1260	0.0270	3.3e-10	0.072	0.098	0.099	0.105	0.105	4.3e-09	5.4e-12	5.1e-12	9.5e-13	9.5e-13
2	GTEx	Liver	0.4640	0.1330	2.8e-03	0.166	NA	0.196	NA	0.057	2.2e-05	NA	3.7e-06	NA	1.1e-02
3	TCGA	Brain Lower Grade Glioma	0.0727	0.0337	1.8e-05	0.030	0.047	0.043	NA	0.037	2.2e-04	4.7e-06	1.2e-05	NA	4.7e-05
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.0880	0.0530	8.8e-03	0.003	0.021	0.019	NA	0.013	2.0e-01	1.4e-02	1.8e-02	NA	4.2e-02
5	TCGA	Thyroid Carcinoma	0.0880	0.0410	1.0e-06	0.050	0.075	0.071	NA	0.063	1.1e-05	9.2e-08	1.8e-07	NA	9.0e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.9	3.0	5.6	-2.4	0.8	-1.8	-1.0	-2.2
Bipolar Disorder or Schizophrenia	3.3	7.9	18.2	-4.3	1.3	-2.9	-1.2	-3.1
Depressed Affect (Nagel 2018)	1.1	2.3	8.4	1.4	-2.9	-1.0	0.1	-0.2
Depression (Nagel 2018)	1.4	2.1	5.7	1.4	-2.4	0.7	1.1	1.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.9	0.7	-0.6	0.1	-0.3
Neuroticism (Nagel 2018)	2.3	5.3	15.7	2.3	-4.0	1.2	1.5	1.4
Schizophrenia (2018)	2.4	5.0	12.8	-3.6	1.0	-2.4	-0.8	-2.2
Schizophrenia vs Biploar Disorder	0.7	0.9	2.0	-1.4	0.7	-0.9	-0.8	-0.8
Worry (Nagel 2018)	1.4	3.0	9.1	0.7	-3.0	1.2	1.1	1.6
Alzheimer’s Disease (in mother)	4.0	4.7	9.4	1.6	-0.5	2.4	2.3	3.1
Alzheimer’s Disease (in father)	1.3	1.4	4.1	-0.6	2.0	0.8	1.2	-0.4
Alzheimer’s Disease (including proxy)	1.5	2.2	3.4	0.4	1.2	1.7	1.7	1.9
Crohns Disease (2017)	0.3	0.6	1.2	-0.7	-1.1	-0.8	-0.2	-0.6
Irritable Bowel Disease (IBD)	0.6	1.5	2.2	-1.5	-1.4	-1.1	-0.2	-1.5
Ulcerative Colitis (UC)	0.8	1.4	2.6	-1.6	-1.6	-0.5	0.2	-1.3
Major Depression (MDD)	1.5	1.8	4.1	-0.9	-0.6	-2.0	-2.0	0.1
Reaction Time	0.6	1.2	5.3	-2.3	0.5	-0.1	0.5	0.0
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.0	-1.4	1.3	-0.4	-0.8	0.0
Breast Cancer	0.3	0.8	1.2	-1.1	-0.7	-0.1	-1.1	1.0
Ovarian Cancer	1.4	1.8	5.2	0.4	-0.3	2.3	-0.4	1.9
Prostate Cancer	2.5	3.5	6.0	1.1	-1.5	2.2	1.8	2.5
Age at First Birth	0.0	0.1	0.2	-0.2	0.2	0.2	0.4	-0.2
Bipolar Disorder (2011)	0.9	0.9	2.2	-1.5	-0.1	-0.9	-0.6	-1.1
Body Mass Index (BMI) (2010)	0.5	0.7	2.1	1.1	-1.4	0.2	0.1	0.4
Coronary Artery Disease (CAD)	0.6	0.7	2.1	0.6	-1.4	0.6	0.5	0.8
Crohns Disease (2012)	0.2	0.4	0.9	-0.3	-0.9	0.1	0.9	0.4
Mean Putamen Volume	1.3	1.4	2.3	-0.6	-1.5	-1.5	0.4	-1.5
Fasting Glucose	2.2	2.6	5.9	1.4	0.5	1.8	2.4	1.2
HbA1C	0.3	0.4	1.1	0.7	1.0	0.3	-0.4	0.3
HDL Cholesterol	0.7	1.1	2.2	0.3	1.4	-0.4	-1.5	-1.0
LDL Cholesterol	0.3	0.5	1.6	-0.1	0.4	-0.7	-1.3	-0.6
Lupus	0.1	0.1	0.7	-0.8	-0.1	0.0	-0.2	0.1
Neuroticism (2016)	0.5	0.7	1.6	0.8	-1.2	0.0	0.8	-0.8
Primary Biliary Cirrhosis	0.3	0.4	1.5	-0.5	0.7	0.1	1.2	0.1
Rheumatoid Arthritis	0.6	0.8	1.5	1.2	0.1	1.2	0.5	1.0
Schizophrenia (2014)	5.6	12.3	26.6	-5.2	1.7	-3.8	-2.0	-3.7
Triglycerides	0.0	0.1	0.2	-0.2	-0.0	-0.1	-0.2	0.5
Type 2 Diabetes (T2D) (2012)	2.1	2.4	11.0	0.8	-3.3	-0.3	-0.2	0.3
Ulcerative Colitis	0.3	0.4	0.9	-0.6	-1.0	-0.5	0.5	-0.5
Blood Eosinophil Count	0.1	0.7	2.0	-1.4	-0.6	0.2	1.0	0.2
Blood Platelet Count	0.1	1.6	6.1	1.2	-2.5	-0.1	0.5	-0.5
Blood Red Count	0.1	0.9	1.8	1.1	-0.1	1.1	0.5	1.4
Blood White Count	0.8	6.0	8.1	2.1	-2.6	2.1	2.4	2.9
Heel T-Score	0.5	3.9	9.9	0.6	0.2	1.8	3.1	2.4
BMI	0.5	2.7	4.5	1.7	-1.4	1.3	1.5	2.1
Height	0.2	3.6	7.8	-1.2	0.2	-2.8	-1.4	-2.6
Waist Hip Ratio (WHR)	0.6	2.8	6.7	1.2	-2.6	0.9	2.0	0.9
Systolic Blood Pressure	0.1	0.7	1.5	0.5	-0.2	-1.2	-1.1	-0.7
Smoking Status	0.9	2.1	3.0	1.7	-0.7	1.5	1.4	1.6
Allergy or Eczema	0.0	0.1	0.3	0.3	-0.1	-0.0	0.6	-0.5
Cardiovascular Disease	0.3	1.1	1.5	1.2	-1.2	-1.2	-1.1	-0.0
Hypothyroidism (self reported)	0.6	1.4	2.6	1.0	-0.5	1.4	0.9	1.6
Respiratory disease	0.6	1.2	4.4	2.1	-1.0	0.6	0.6	-0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.1	1.1	-1.0	0.9	0.3	0.8
Lung FEV1/FVC ratio	0.3	1.4	1.7	-1.3	-1.3	-1.3	-0.8	-1.3
Lung FVC	0.7	3.4	13.1	-1.9	3.6	-0.0	-0.1	0.4
Neuroticism	0.9	2.2	10.1	0.8	-3.2	-0.0	0.2	0.1
Chronotype (morning person)	0.5	1.1	2.0	1.1	0.2	1.3	0.9	1.4
Hair Pigment	0.1	2.2	5.5	0.1	0.1	2.3	0.7	2.4
Tanning	0.2	2.4	4.9	-1.5	0.8	-2.2	-1.3	-1.5
Hand grip strength (left)	2.7	7.0	10.4	3.0	-1.2	2.8	2.5	3.2
Number of treatments/medications taken	2.4	4.2	11.0	3.0	-3.3	0.5	-0.4	1.1
Average weekly spirits intake	0.9	1.1	2.8	0.8	-1.7	-0.7	-0.9	-0.6
Sensitivity / hurt feelings	1.0	1.8	6.1	1.3	-2.5	0.9	0.3	0.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.5	1.0	-0.8	0.7	1.2	0.7
Hearing difficulty/problems: Yes	0.5	0.7	1.9	1.4	-1.0	0.8	-0.1	0.0
Relative age of first facial hair	0.2	0.5	1.4	-0.5	0.6	-0.4	-1.2	-0.1
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	6.5	0.4	-2.5	0.5	1.0	1.3
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.0	-0.0	-2.0	-2.0	-0.4	-1.8
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	0.3	0.9	0.2	0.7	0.4
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.2	-0.5	-0.7	-0.5	-0.3
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	7.0	2.0	0.1	1.6	2.6	1.7
Angina	0.1	0.2	0.5	0.7	-0.6	0.1	-0.1	-0.2
Medication for hormone replacement therapy	2.5	2.8	3.9	-1.9	0.5	-1.8	-1.7	-2.0
Vitamin and mineral supplements	0.2	0.2	0.7	0.4	-0.5	-0.1	0.9	0.2
Supplements: Zinc	0.3	0.4	1.1	0.2	0.8	0.4	1.0	-0.2
Medication: Co-codamol	1.1	1.2	3.0	1.7	-1.2	1.2	-0.1	0.6
Medication: Metformin	0.2	0.3	0.8	0.3	0.9	-0.3	0.7	0.4
Diabetes (father)	0.3	0.3	0.9	0.9	0.5	0.3	-0.6	-0.2
Diabetes (mother)	0.6	0.8	1.7	-1.3	-0.5	-1.0	0.5	-0.8
Severe depression (siblings)	0.8	0.9	2.4	-0.3	-1.1	-0.8	-1.6	-0.0
Pack years adult smoking proportion	0.3	0.4	1.4	-0.1	-1.2	0.5	0.4	0.5
Impedance of leg (right)	0.2	1.0	2.0	-1.1	1.1	-0.3	-1.4	-0.7
Leg fat-free mass (left)	0.1	0.3	0.8	0.1	-0.9	-0.7	0.3	-0.1
Trunk fat percentage	0.1	0.5	1.4	1.2	-0.5	0.1	-0.2	0.9
Hand grip strength (right)	0.6	1.8	4.1	1.7	-0.2	1.1	0.8	2.0
Townsend deprivation index at recruitment	1.1	1.6	2.9	1.5	0.0	1.7	1.2	1.3
Current tobacco smoking	0.1	0.2	0.8	-0.3	-0.1	-0.1	0.9	0.4
Average weekly fortified wine intake	0.5	0.6	1.3	0.8	-0.3	0.7	0.4	1.1
Maternal smoking around birth	0.4	0.6	1.3	0.5	-0.1	0.8	0.8	1.1
Fed-up feelings	0.2	0.4	0.9	0.5	-0.7	-1.0	0.2	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	1.7	1.2	-1.0	1.1	0.9	1.3
Relative age voice broke	0.5	0.8	3.3	-0.2	1.8	0.3	-0.7	0.4
Taking other prescription medications	2.5	3.9	6.8	2.6	-2.6	1.3	1.3	1.7
Age when periods started (menarche)	0.4	0.9	1.5	1.2	-1.2	0.1	-1.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.1	0.8	-1.5	-0.1	0.4	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.1	-0.1	0.5	0.9	1.0	0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.6	0.7	1.3	0.9	0.7	0.9
Qualifications: CSEs or equivalent	1.7	2.3	5.2	-2.3	1.6	-1.5	-0.5	-1.0
Serious illness, injury or assault to yourself	0.5	0.6	1.7	0.5	-0.5	0.4	0.7	1.3
High blood pressure	0.4	1.2	2.6	1.0	-0.6	-1.5	-1.6	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	0.7	-0.6	0.4	0.9	-0.1
Multivitamins +/- minerals	1.2	1.6	2.4	1.2	-1.5	1.5	0.9	1.0
Stomach or abdominal pain in last month	0.1	0.2	0.4	0.4	0.1	0.0	0.6	0.6
Supplements: Glucosamine	0.2	0.3	0.4	0.0	-0.6	0.6	-0.6	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	0.2	-1.0	-0.9	-0.1	-0.9
Medication: Atenolol	0.5	0.7	1.9	1.1	-1.4	-0.2	-0.1	0.4
Medication: Levothyroxine sodium	0.5	0.9	1.9	0.9	-0.6	0.9	1.4	0.7
Sitting height	0.5	3.6	5.2	-1.8	1.8	-1.6	-2.3	-1.9
Chronic bronchitis/emphysema (father)	6.1	7.2	14.7	3.8	-0.8	3.3	1.8	2.5
High blood pressure (mother)	1.3	1.8	5.8	0.5	-2.4	-1.4	-0.8	-0.8
Body mass index (BMI)	0.6	2.4	4.2	2.1	-1.6	1.0	1.2	1.7
Impedance of leg (left)	0.2	1.0	2.0	-1.0	1.4	-0.0	-1.4	-0.3
Leg predicted mass (left)	0.0	0.3	0.8	0.2	-0.9	-0.6	0.4	0.1
Trunk fat mass	0.1	0.6	1.6	1.3	-0.8	0.1	-0.1	0.9
Waist circumference	0.4	1.3	3.4	1.3	-1.8	0.1	1.0	0.8
Number of incorrect matches in round	0.2	0.3	1.0	-0.5	0.4	-0.5	-0.2	-1.0
Past tobacco smoking	2.4	4.5	8.1	-2.9	1.9	-2.3	-1.5	-1.8
Alcohol usually taken with meals	0.1	0.2	0.7	-0.8	0.2	0.2	-0.3	0.2
Nervous feelings	0.5	0.9	2.0	-0.8	-1.4	0.4	1.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.3	-0.0	0.5	-0.2	1.1	-0.0
Hearing difficulty/problems with background noise	0.9	1.4	5.1	0.1	-2.2	-0.7	-0.4	-1.0
Hair/balding pattern: Pattern 2	0.4	0.5	1.6	-0.4	1.3	-0.3	-0.7	-0.2
Had menopause	0.2	0.2	0.4	0.6	-0.6	-0.2	0.3	-0.3
Had other major operations	0.3	0.4	0.7	-0.7	-0.8	-0.8	-0.1	-0.1
Forced vital capacity (FVC)	0.4	1.4	5.1	-1.3	2.3	-0.4	0.3	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	-1.2	1.3	-0.2	-0.1	0.1
Ever unenthusiastic/disinterested for a whole week	3.7	4.5	6.7	2.4	-0.4	2.2	2.2	2.6
Qualifications: None of the above	1.5	3.2	5.7	2.3	-1.2	1.1	2.4	1.5
Financial difficulties in last 2 years	0.2	0.3	0.9	-1.0	0.4	-0.1	-0.5	0.1
Mouth/teeth dental problems	0.9	1.5	3.4	-0.7	1.3	-1.3	-0.3	-1.8
Heart attack	0.4	0.5	1.5	1.2	0.1	0.7	-0.5	0.5
Allergy	0.8	1.9	4.1	-2.0	1.3	-1.3	-1.2	-0.9
Pain all over the body in last month	0.2	0.2	0.6	0.6	0.0	0.1	-0.2	0.8
Diabetes (self-reported)	0.1	0.2	0.3	0.5	0.2	-0.3	0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.3	-0.6	0.4	0.7	0.1
Medication: Ramipril	1.3	1.6	3.2	1.8	-1.0	1.1	-0.5	1.6
Medication: Simvastatin	1.8	2.7	8.4	2.9	-0.9	1.4	0.0	1.5
Fluid intelligence score	0.1	0.2	0.9	-0.9	0.1	0.0	0.2	0.5
Illnesses of siblings	1.1	1.5	4.1	-2.0	-0.1	-1.4	-0.4	-1.1
Neuroticism score	0.7	1.4	6.0	0.6	-2.4	-0.1	0.9	-0.2
Weight	0.1	0.6	1.1	1.0	-1.0	0.1	0.6	0.9
Impedance of arm (right)	0.3	1.2	2.1	-0.9	1.4	-0.7	-1.4	-0.9
Arm fat percentage (right)	0.3	1.1	2.7	1.6	-1.2	0.3	0.4	1.1
Trunk fat-free mass	0.1	0.4	1.2	0.4	-1.1	-0.2	0.8	-0.1
Hip circumference	0.1	0.5	1.4	1.2	-0.8	0.1	-0.1	0.5
Time employed in main current job	0.3	0.4	1.1	-0.6	1.0	-0.4	0.4	0.3
Alcohol intake versus 10 years previously	0.5	0.8	3.0	-0.2	1.7	-0.5	-0.8	0.1
Father’s age at death	0.3	0.4	0.8	0.7	-0.8	0.3	0.9	-0.4
Worrier / anxious feelings	1.7	3.3	7.7	1.4	-2.8	1.4	1.5	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.6	1.4	-2.1	-0.4	0.3	-0.7
Falls in the last year	0.2	0.3	0.5	0.4	-0.6	0.3	-0.7	0.5
Hair/balding pattern: Pattern 3	0.7	1.1	4.3	-0.8	-2.1	-0.1	0.5	0.4
Number of live births	1.0	1.4	2.6	0.7	1.5	1.1	1.6	0.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.2	-2.3	2.2	-1.0	0.0	-0.7
Pulse rate	0.6	0.9	3.1	-0.3	1.0	0.6	1.8	0.5
Happiness	0.5	0.6	1.2	-0.0	-0.6	-1.1	-1.1	-0.7
Noisy workplace	4.2	5.1	13.3	2.3	-3.7	1.6	0.9	2.0
Qualifications: A levels/AS levels or equivalent	1.3	3.0	5.8	-2.4	0.5	-1.0	-2.1	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.6	-1.6	1.9	-0.1	-0.1	-0.3
Mouth/teeth dental problems: Dentures	4.5	7.6	10.7	2.9	-3.3	2.3	2.2	2.9
Asthma	0.9	1.8	6.9	2.6	-1.2	0.7	0.4	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.8	-0.2	-0.9	-0.1	0.2	-0.6
Medication: Cholesterol lowering	1.0	1.5	4.2	2.0	0.3	1.1	0.1	1.4
Depression (self-reported)	0.7	0.8	1.6	0.2	-1.3	0.5	1.1	1.1
Medication: Lansoprazole	0.9	1.0	1.8	-0.8	-0.3	-1.0	-1.1	-1.3
Prospective memory result	0.2	0.2	0.8	-0.2	0.2	-0.0	-0.4	-0.9
Lung cancer (father)	1.3	1.5	2.9	-0.4	0.3	1.5	1.7	1.5
Illnesses of mother	1.5	1.8	7.0	-1.2	2.6	0.0	-0.8	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	6.7	-2.6	2.3	-1.5	-0.9	-1.2
Pulse wave Arterial Stiffness index	0.8	0.9	1.4	0.9	1.2	1.0	-0.9	0.9
Impedance of arm (left)	0.4	1.9	4.7	-1.1	2.2	-0.7	-1.3	-1.0
Arm fat mass (right)	0.4	1.5	2.8	1.7	-1.5	0.5	0.8	1.3
Trunk predicted mass	0.1	0.5	1.5	0.5	-1.2	-0.1	0.9	0.0
Standing height	0.2	1.8	2.7	-1.6	0.9	-1.6	-1.0	-1.4
Length of working week for main job	0.8	0.9	2.9	1.7	-1.1	0.5	0.1	0.4
Exposure to tobacco smoke at home	0.2	0.3	0.4	0.6	0.2	-0.6	-0.6	-0.4
Breastfed as a baby	0.4	0.5	2.1	-0.1	1.5	0.3	-0.0	-0.5
Tense / ‘highly strung’	0.8	1.3	2.6	0.1	-1.6	0.9	1.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	-0.2	-0.9	0.2	1.3	0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-0.3	0.7	-0.2	-1.1	-0.8
Birth weight of first child	0.0	0.0	0.1	-0.3	0.0	0.0	-0.3	-0.1
Peak expiratory flow (PEF)	1.5	3.5	7.7	-2.8	2.1	-1.8	-0.2	-1.5
Pulse wave reflection index	1.0	1.3	2.3	1.3	-0.7	1.1	-0.8	1.5
Ever highly irritable/argumentative for 2 days	3.4	4.1	6.4	2.0	-0.1	2.3	2.5	2.2
Loud music exposure frequency	0.6	0.6	1.4	-0.9	0.8	-0.1	-1.2	-0.4
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.8	-1.9	0.4	-0.2	0.2	-0.6
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.9	-1.1	1.4	0.2	-1.1	-0.5
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.7	0.5	0.2	-0.2	0.8
Medication: Paracetamol	0.5	0.8	2.2	-0.8	0.0	-1.5	-0.7	-0.8
Headache pain in last month	0.3	0.5	1.0	0.1	0.9	1.0	-0.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	5.8	-2.4	-0.1	-0.6	0.2	-1.2
Glaucoma (self-reported)	0.3	0.4	0.6	0.7	0.6	0.6	0.5	0.7
Gout (self-reported)	1.3	1.7	3.2	1.7	-1.8	1.0	0.8	0.8
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	2.9	1.6	-0.8	1.5	1.7	1.6
Medication: Amlodipine	1.1	1.5	4.3	1.2	-0.1	1.3	0.1	2.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.7	0.2	0.0	-0.3	1.3	-1.2
Birth weight	0.6	1.3	1.9	-1.0	1.3	-1.4	-0.5	-1.3
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.7	1.3	-0.7	1.2	1.6	1.2
High blood pressure (siblings)	0.7	1.1	4.2	2.1	-0.7	0.6	-0.0	0.5
Forced vital capacity (FVC), Best measure	0.6	2.1	6.8	-1.7	2.6	-0.6	-0.4	-0.3
Body fat percentage	0.3	1.0	2.4	1.6	-1.0	0.4	-0.0	1.2
Leg fat percentage (right)	0.5	1.8	3.6	1.9	-1.9	0.5	-0.0	1.3
Arm fat-free mass (right)	0.1	0.5	1.4	0.4	-1.2	-0.2	0.8	0.1
Exposure to tobacco smoke outside home	0.5	0.6	1.0	1.0	-1.0	0.7	-0.7	0.5
Comparative body size at age 10	1.9	5.1	16.3	4.0	-1.4	1.4	1.3	1.9
Number of full brothers	1.1	1.4	2.6	0.8	-1.2	1.1	1.1	1.6
Worry too long after embarrassment	0.5	0.8	2.4	0.8	-1.6	0.7	0.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	5.2	1.0	-2.0	1.9	2.3	2.0
Wheeze or whistling in the chest in last year	2.5	4.5	10.0	3.0	-3.2	1.1	1.5	0.4
Number of children fathered	0.7	0.8	1.6	-0.9	0.6	-1.1	-1.3	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.1	-0.1	0.1	0.3	-0.1
Age at first live birth	0.2	0.4	1.6	-0.4	-0.1	0.0	-1.3	0.0
Pulse wave peak to peak time	1.0	1.2	1.7	-1.2	-0.9	-1.2	0.7	-1.3
Health satisfaction	0.4	0.5	1.9	0.6	-1.4	-0.2	0.4	-0.1
Shortness of breath walking on level ground	1.2	1.4	2.5	1.6	-0.8	1.2	0.9	1.2
Qualifications: College or University degree	0.3	1.1	2.4	-1.5	-0.3	-0.7	0.4	-1.5
Eye problems/disorders: None of the above	3.9	4.6	8.0	-1.6	0.6	-2.3	-2.8	-2.6
Mouth/teeth dental problems: Loose teeth	1.6	1.9	2.6	1.0	-1.4	1.1	1.6	1.6
Emphysema/chronic bronchitis	3.5	3.9	4.9	2.1	-1.9	2.2	1.9	1.8
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	-0.4	0.0	0.5	0.5	0.3
Neck or shoulder pain in last month	0.4	0.5	2.3	-0.3	1.5	-0.3	0.0	-0.4
Medication: Blood pressure	0.5	0.8	2.8	1.7	0.2	0.3	-0.1	1.1
Angina (self-reported)	0.1	0.2	0.5	0.7	-0.7	0.0	-0.0	-0.2
Migraine (self-reported)	0.7	0.9	2.7	1.0	0.6	-0.2	-1.7	-0.4
Medication: Ibuprofen	0.2	0.2	1.1	-0.1	-1.0	-0.1	0.1	-0.2
Medication: Allopurinol	0.3	0.3	0.9	0.6	-0.9	0.2	0.5	0.3
Medication: Omeprazole	0.6	0.7	2.0	-0.3	-1.4	-0.6	-0.4	-0.9
Medication: Seretide 50 evohaler	2.7	3.1	5.8	2.4	-1.9	1.8	1.5	0.6
Mean time to correctly identify matches	0.3	0.6	2.6	-1.6	-0.2	-0.1	0.5	-0.2
Heart disease (mother)	0.2	0.2	0.5	0.6	-0.1	0.4	0.2	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.6	-0.8	-0.8	-0.2	-0.5	0.3
Whole body fat mass	0.2	0.9	2.3	1.5	-1.1	0.3	0.0	1.1
Leg fat mass (right)	0.5	1.9	3.4	1.9	-1.8	0.5	0.3	1.5
Arm predicted mass (right)	0.1	0.4	1.1	0.5	-1.0	-0.2	0.6	0.1
Pulse rate, automated reading	0.3	0.9	2.2	0.9	0.5	1.0	1.5	0.6
Alcohol intake frequency.	1.1	2.4	4.8	2.2	-0.4	1.5	1.6	1.5
Comparative height size at age 10	0.1	0.4	1.1	-0.4	0.3	-0.6	-1.1	-0.5
Number of full sisters	0.9	1.1	3.5	-0.0	1.9	-0.6	-1.1	-0.7
Suffer from ‘nerves’	0.1	0.2	0.5	-0.4	-0.7	0.2	0.5	0.2
Overall health rating	0.0	0.1	0.3	0.5	0.3	0.1	0.0	-0.1
Chest pain or discomfort	0.3	0.4	1.6	0.6	-0.1	0.1	-1.3	0.1
Had major operations	0.5	0.5	2.6	0.2	0.1	-0.1	-1.6	-0.3
Age at last live birth	0.6	0.9	1.2	0.9	-0.9	1.0	-0.5	1.1
Family relationship satisfaction	0.5	0.6	1.3	1.1	-1.1	0.2	0.0	0.7
Leg pain on walking	2.1	2.6	4.0	1.1	-1.4	1.7	2.0	1.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	-0.5	0.8	0.4	-0.3	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.4	-0.6	-0.8	-0.0	-0.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.3	-0.8	1.0	-1.0	0.1	-1.1
Medication: Aspirin	0.3	0.4	1.3	1.1	0.2	0.0	-0.9	0.3
Supplements: Vitamin C	3.3	3.8	7.8	-2.8	2.6	-1.4	-1.0	-1.3
Knee pain experienced in last month	0.2	0.3	1.0	-1.0	-0.0	-0.5	-0.0	-0.2
Hypertension (Self-reported)	0.4	1.1	2.1	1.1	-0.6	-1.3	-1.4	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.2	-0.2	-1.3	-0.8	-1.3	-1.8
Illnesses of father: Heart disease	1.2	1.7	4.4	2.1	-1.8	0.0	-0.9	0.2
Illnesses of siblings: Diabetes	0.5	0.7	1.8	1.3	-0.9	0.8	0.2	0.3
Smoking status: Previous	3.1	4.6	8.7	2.9	-1.4	2.6	1.6	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.5	-1.5	1.9	-1.5	-0.9	-1.6
Whole body fat-free mass	0.1	0.3	1.0	0.3	-1.0	-0.4	0.6	-0.1
Leg fat-free mass (right)	0.0	0.2	0.6	-0.0	-0.6	-0.8	0.3	-0.1
Arm fat percentage (left)	0.2	0.9	2.5	1.6	-0.9	0.3	0.3	1.1
Average weekly red wine intake	0.3	0.5	1.3	-1.1	0.7	-0.5	-0.3	-0.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.3	-0.2	1.5	0.1	0.6	0.4
Mood swings	2.0	3.6	6.7	2.6	-2.2	1.3	1.9	1.0
Loneliness, isolation	0.8	1.2	2.5	-1.5	-0.4	-1.6	0.5	-0.9
Long-standing illness, disability or infirmity	0.9	1.4	3.1	1.8	-1.6	0.6	0.0	1.0
Ever had bowel cancer screening	0.5	0.6	1.0	-0.3	-0.6	-0.9	0.9	-1.0
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.6	-0.1	-0.4	0.1	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.7	0.3	-0.4	0.7	-0.1	1.3
Friendships satisfaction	2.8	3.5	5.7	-1.6	-1.5	-2.4	-1.6	-2.1
Qualifications: nursing, teaching	0.4	0.7	1.5	-0.3	-1.2	0.8	-0.6	0.9
Commuting to job workplace: Walk	1.2	1.3	3.8	0.2	0.2	1.2	1.9	1.1
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.3	0.4	0.6	0.4	0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.2	-1.1	-0.4	-1.0	-0.7	-0.9
Medication for cholesterol	1.9	2.9	9.2	-0.2	3.0	1.5	1.3	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.7	1.0	0.6	1.1	1.9	1.8
Back pain experienced in last month	0.2	0.3	0.8	0.9	-0.5	0.4	0.5	-0.1
Mineral and other dietary supplements	0.1	0.1	0.4	0.0	0.0	-0.4	0.2	-0.6
Breast cancer (self-reported)	0.9	1.0	2.7	-0.7	0.3	-1.6	-0.4	-1.3
Asthma (self-reported)	0.8	1.5	6.2	2.5	-0.7	0.7	0.6	-0.1
Osteoporosis (self-reported)	0.2	0.2	0.3	0.5	-0.6	-0.5	-0.5	-0.3
Osteoarthritis (self-reported)	0.7	0.9	2.6	0.9	-1.6	0.6	0.5	0.4
Medication: Aspirin	0.4	0.5	1.4	1.1	-0.1	-0.2	-1.2	-0.0
Medication: Gliclazide	1.0	1.2	2.3	1.5	-1.3	0.9	0.5	0.8
Illnesses of father: None of the above (group 1)	1.7	2.1	7.4	-2.7	1.1	-0.7	1.0	-0.6
Smoking status: Current	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	-1.4	1.1	-0.7	-0.2	-0.5
Whole body water mass	0.1	0.3	1.0	0.2	-1.0	-0.4	0.7	-0.1
Leg predicted mass (right)	0.0	0.2	0.6	0.0	-0.5	-0.8	0.3	-0.1
Arm fat mass (left)	0.3	1.1	2.3	1.5	-1.3	0.2	0.6	1.0
Number of self-reported non-cancer illnesses	0.7	1.3	3.3	1.8	-1.6	-0.0	-0.3	0.7
Average weekly champagne plus white wine intake	0.8	1.1	3.6	-1.9	1.2	-0.3	0.5	-0.6
Miserableness	0.6	1.0	1.8	1.4	-1.4	-1.0	0.1	-0.3
Guilty feelings	0.2	0.3	0.6	0.8	-0.3	0.7	0.3	0.2
Wears glasses or contact lenses	0.5	0.6	1.2	0.5	-0.9	0.5	1.1	0.7
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.7	-0.2	0.1	0.6	-0.1
Hearing aid user	2.8	3.1	5.8	2.0	0.3	2.4	2.0	1.4
Mother’s age at death	0.4	0.5	1.2	-0.3	-1.1	-0.6	-0.2	-0.9
Financial situation satisfaction	0.9	1.1	1.5	-1.1	1.0	-1.2	-0.6	-1.0
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.4	-0.6	0.3	-0.5	-0.6	-0.5
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.4	0.7	-0.4	0.4	-0.8
Eye problems/disorders: Glaucoma	1.1	1.3	1.9	1.4	-0.3	1.2	1.0	1.3
Medication: Blood pressure	2.0	3.8	13.5	1.5	-3.7	-0.5	-1.7	0.0
Pain type(s) experienced in last month: Hip pain	6.8	8.6	14.6	2.5	1.6	3.1	3.8	3.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	0.5	-0.4	0.4	-0.1	0.8
High cholesterol (Self-reported)	0.6	1.0	3.2	1.8	-0.5	0.4	1.2	0.2
Medication: Bendroflumethiazide	2.8	4.3	12.0	2.3	-3.5	0.8	-0.8	1.7
Medication: Paracetamol	0.1	0.2	0.6	0.1	-0.7	-0.4	-0.1	0.1
Medication: Lisinopril	0.8	1.0	2.0	1.4	-0.3	0.8	1.4	0.6
Medication: Atorvastatin	1.1	1.3	2.9	1.3	-0.4	1.1	0.7	1.7
Illnesses of father: High blood pressure	0.3	0.4	1.2	1.1	-0.5	-0.8	0.1	0.3
Alcohol drinker status: Never	2.0	2.4	4.6	1.6	-0.2	1.7	2.1	1.5
Ever smoked	0.5	0.9	1.3	0.8	-0.9	0.9	0.8	1.2
Basal metabolic rate	0.1	0.4	1.1	0.4	-1.1	-0.4	0.7	0.1
Leg fat percentage (left)	0.5	1.8	3.8	2.0	-1.7	0.6	0.0	1.5
Arm fat-free mass (left)	0.2	0.9	2.7	0.8	-1.6	0.1	1.1	0.4
Number of operations (self-reported)	1.2	1.7	4.2	1.4	-2.0	0.4	0.4	1.5
Average weekly beer plus cider intake	0.6	0.8	2.5	0.1	-1.6	-0.7	-0.7	-0.9
Irritability	0.7	1.3	2.7	1.6	-1.5	0.6	1.0	0.0
Risk taking	0.3	0.4	1.4	0.3	1.2	0.6	-0.1	0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.0	0.5	0.8	0.4	-0.9	1.0
Fractured/broken bones in last 5 years	0.5	0.7	1.1	-0.3	-0.7	-0.8	1.0	-1.1
Age started oral contraceptive pill	0.4	0.5	1.8	0.3	-1.3	-0.6	-0.0	-0.6
Diastolic blood pressure, automated reading	0.2	0.5	1.3	-0.1	1.0	-0.6	-1.1	-0.0
Ever depressed for a whole week	4.4	5.4	9.4	1.6	0.1	3.1	2.4	3.0
Unable to work because of sickness or disability	0.8	1.1	1.5	1.0	1.2	1.1	-0.5	1.1
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.7	0.1	0.7	-0.5	0.2
Myopia	0.5	0.7	1.3	-0.7	0.9	-0.6	-1.1	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.6	-1.6	0.2	0.5	0.9	-0.5
Cholesterol lowering medication	2.9	4.3	8.4	2.6	-2.9	1.4	1.8	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.2	-0.4	-1.1	-0.8	-0.3	-1.1
Pain experienced in last month	0.1	0.2	0.7	-0.3	-0.8	-0.1	0.0	-0.2
Supplements: Calcium	0.8	0.8	1.9	-0.7	0.6	-1.4	-0.8	-0.9
Basal cell carcinoma (self-reported)	1.0	1.2	4.1	-0.1	0.8	-1.0	-0.6	-2.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	1.0	0.2	0.4	-0.7	0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.9	0.5	0.4	-0.1	0.6
Heart disease (siblings)	3.9	4.8	9.1	2.4	0.3	3.0	1.4	2.7
Alcohol drinker status: Previous	1.9	2.1	6.5	2.5	-1.9	0.8	0.1	0.3
Pack years of smoking	0.3	0.4	1.4	0.1	-1.2	0.5	0.3	0.6
Impedance of whole body	0.4	2.0	3.4	-1.4	1.8	-0.7	-1.8	-1.0
Leg fat mass (left)	0.5	2.1	4.1	2.0	-1.7	0.6	0.2	1.7
Arm predicted mass (left)	0.2	1.0	2.7	0.8	-1.6	0.1	1.1	0.5