Hub : Genes

VPS37A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1260 0.0270 3.3e-10 0.072 0.098 0.099 0.105 0.105 4.3e-09 5.4e-12 5.1e-12 9.5e-13 9.5e-13
2 GTEx Liver 0.4640 0.1330 2.8e-03 0.166 NA 0.196 NA 0.057 2.2e-05 NA 3.7e-06 NA 1.1e-02
3 TCGA Brain Lower Grade Glioma 0.0727 0.0337 1.8e-05 0.030 0.047 0.043 NA 0.037 2.2e-04 4.7e-06 1.2e-05 NA 4.7e-05
4 TCGA Ovarian Serous Cystadenocarcinoma 0.0880 0.0530 8.8e-03 0.003 0.021 0.019 NA 0.013 2.0e-01 1.4e-02 1.8e-02 NA 4.2e-02
5 TCGA Thyroid Carcinoma 0.0880 0.0410 1.0e-06 0.050 0.075 0.071 NA 0.063 1.1e-05 9.2e-08 1.8e-07 NA 9.0e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.9 3.0 5.6 -2.4 0.8 -1.8 -1.0 -2.2
Bipolar Disorder or Schizophrenia 3.3 7.9 18.2 -4.3 1.3 -2.9 -1.2 -3.1
Depressed Affect (Nagel 2018) 1.1 2.3 8.4 1.4 -2.9 -1.0 0.1 -0.2
Depression (Nagel 2018) 1.4 2.1 5.7 1.4 -2.4 0.7 1.1 1.1
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.8 -0.9 0.7 -0.6 0.1 -0.3
Neuroticism (Nagel 2018) 2.3 5.3 15.7 2.3 -4.0 1.2 1.5 1.4
Schizophrenia (2018) 2.4 5.0 12.8 -3.6 1.0 -2.4 -0.8 -2.2
Schizophrenia vs Biploar Disorder 0.7 0.9 2.0 -1.4 0.7 -0.9 -0.8 -0.8
Worry (Nagel 2018) 1.4 3.0 9.1 0.7 -3.0 1.2 1.1 1.6
Alzheimer’s Disease (in mother) 4.0 4.7 9.4 1.6 -0.5 2.4 2.3 3.1
Alzheimer’s Disease (in father) 1.3 1.4 4.1 -0.6 2.0 0.8 1.2 -0.4
Alzheimer’s Disease (including proxy) 1.5 2.2 3.4 0.4 1.2 1.7 1.7 1.9
Crohns Disease (2017) 0.3 0.6 1.2 -0.7 -1.1 -0.8 -0.2 -0.6
Irritable Bowel Disease (IBD) 0.6 1.5 2.2 -1.5 -1.4 -1.1 -0.2 -1.5
Ulcerative Colitis (UC) 0.8 1.4 2.6 -1.6 -1.6 -0.5 0.2 -1.3
Major Depression (MDD) 1.5 1.8 4.1 -0.9 -0.6 -2.0 -2.0 0.1
Reaction Time 0.6 1.2 5.3 -2.3 0.5 -0.1 0.5 0.0
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.0 -1.4 1.3 -0.4 -0.8 0.0
Breast Cancer 0.3 0.8 1.2 -1.1 -0.7 -0.1 -1.1 1.0
Ovarian Cancer 1.4 1.8 5.2 0.4 -0.3 2.3 -0.4 1.9
Prostate Cancer 2.5 3.5 6.0 1.1 -1.5 2.2 1.8 2.5
Age at First Birth 0.0 0.1 0.2 -0.2 0.2 0.2 0.4 -0.2
Bipolar Disorder (2011) 0.9 0.9 2.2 -1.5 -0.1 -0.9 -0.6 -1.1
Body Mass Index (BMI) (2010) 0.5 0.7 2.1 1.1 -1.4 0.2 0.1 0.4
Coronary Artery Disease (CAD) 0.6 0.7 2.1 0.6 -1.4 0.6 0.5 0.8
Crohns Disease (2012) 0.2 0.4 0.9 -0.3 -0.9 0.1 0.9 0.4
Mean Putamen Volume 1.3 1.4 2.3 -0.6 -1.5 -1.5 0.4 -1.5
Fasting Glucose 2.2 2.6 5.9 1.4 0.5 1.8 2.4 1.2
HbA1C 0.3 0.4 1.1 0.7 1.0 0.3 -0.4 0.3
HDL Cholesterol 0.7 1.1 2.2 0.3 1.4 -0.4 -1.5 -1.0
LDL Cholesterol 0.3 0.5 1.6 -0.1 0.4 -0.7 -1.3 -0.6
Lupus 0.1 0.1 0.7 -0.8 -0.1 0.0 -0.2 0.1
Neuroticism (2016) 0.5 0.7 1.6 0.8 -1.2 0.0 0.8 -0.8
Primary Biliary Cirrhosis 0.3 0.4 1.5 -0.5 0.7 0.1 1.2 0.1
Rheumatoid Arthritis 0.6 0.8 1.5 1.2 0.1 1.2 0.5 1.0
Schizophrenia (2014) 5.6 12.3 26.6 -5.2 1.7 -3.8 -2.0 -3.7
Triglycerides 0.0 0.1 0.2 -0.2 -0.0 -0.1 -0.2 0.5
Type 2 Diabetes (T2D) (2012) 2.1 2.4 11.0 0.8 -3.3 -0.3 -0.2 0.3
Ulcerative Colitis 0.3 0.4 0.9 -0.6 -1.0 -0.5 0.5 -0.5
Blood Eosinophil Count 0.1 0.7 2.0 -1.4 -0.6 0.2 1.0 0.2
Blood Platelet Count 0.1 1.6 6.1 1.2 -2.5 -0.1 0.5 -0.5
Blood Red Count 0.1 0.9 1.8 1.1 -0.1 1.1 0.5 1.4
Blood White Count 0.8 6.0 8.1 2.1 -2.6 2.1 2.4 2.9
Heel T-Score 0.5 3.9 9.9 0.6 0.2 1.8 3.1 2.4
BMI 0.5 2.7 4.5 1.7 -1.4 1.3 1.5 2.1
Height 0.2 3.6 7.8 -1.2 0.2 -2.8 -1.4 -2.6
Waist Hip Ratio (WHR) 0.6 2.8 6.7 1.2 -2.6 0.9 2.0 0.9
Systolic Blood Pressure 0.1 0.7 1.5 0.5 -0.2 -1.2 -1.1 -0.7
Smoking Status 0.9 2.1 3.0 1.7 -0.7 1.5 1.4 1.6
Allergy or Eczema 0.0 0.1 0.3 0.3 -0.1 -0.0 0.6 -0.5
Cardiovascular Disease 0.3 1.1 1.5 1.2 -1.2 -1.2 -1.1 -0.0
Hypothyroidism (self reported) 0.6 1.4 2.6 1.0 -0.5 1.4 0.9 1.6
Respiratory disease 0.6 1.2 4.4 2.1 -1.0 0.6 0.6 -0.2
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.1 1.1 -1.0 0.9 0.3 0.8
Lung FEV1/FVC ratio 0.3 1.4 1.7 -1.3 -1.3 -1.3 -0.8 -1.3
Lung FVC 0.7 3.4 13.1 -1.9 3.6 -0.0 -0.1 0.4
Neuroticism 0.9 2.2 10.1 0.8 -3.2 -0.0 0.2 0.1
Chronotype (morning person) 0.5 1.1 2.0 1.1 0.2 1.3 0.9 1.4
Hair Pigment 0.1 2.2 5.5 0.1 0.1 2.3 0.7 2.4
Tanning 0.2 2.4 4.9 -1.5 0.8 -2.2 -1.3 -1.5
Hand grip strength (left) 2.7 7.0 10.4 3.0 -1.2 2.8 2.5 3.2
Number of treatments/medications taken 2.4 4.2 11.0 3.0 -3.3 0.5 -0.4 1.1
Average weekly spirits intake 0.9 1.1 2.8 0.8 -1.7 -0.7 -0.9 -0.6
Sensitivity / hurt feelings 1.0 1.8 6.1 1.3 -2.5 0.9 0.3 0.6
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.5 1.0 -0.8 0.7 1.2 0.7
Hearing difficulty/problems: Yes 0.5 0.7 1.9 1.4 -1.0 0.8 -0.1 0.0
Relative age of first facial hair 0.2 0.5 1.4 -0.5 0.6 -0.4 -1.2 -0.1
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 6.5 0.4 -2.5 0.5 1.0 1.3
Ever used hormone-replacement therapy (HRT) 1.8 2.3 4.0 -0.0 -2.0 -2.0 -0.4 -1.8
Ever had hysterectomy (womb removed) 0.3 0.3 0.8 0.3 0.9 0.2 0.7 0.4
Systolic blood pressure, automated reading 0.1 0.2 0.5 0.2 -0.5 -0.7 -0.5 -0.3
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 7.0 2.0 0.1 1.6 2.6 1.7
Angina 0.1 0.2 0.5 0.7 -0.6 0.1 -0.1 -0.2
Medication for hormone replacement therapy 2.5 2.8 3.9 -1.9 0.5 -1.8 -1.7 -2.0
Vitamin and mineral supplements 0.2 0.2 0.7 0.4 -0.5 -0.1 0.9 0.2
Supplements: Zinc 0.3 0.4 1.1 0.2 0.8 0.4 1.0 -0.2
Medication: Co-codamol 1.1 1.2 3.0 1.7 -1.2 1.2 -0.1 0.6
Medication: Metformin 0.2 0.3 0.8 0.3 0.9 -0.3 0.7 0.4
Diabetes (father) 0.3 0.3 0.9 0.9 0.5 0.3 -0.6 -0.2
Diabetes (mother) 0.6 0.8 1.7 -1.3 -0.5 -1.0 0.5 -0.8
Severe depression (siblings) 0.8 0.9 2.4 -0.3 -1.1 -0.8 -1.6 -0.0
Pack years adult smoking proportion 0.3 0.4 1.4 -0.1 -1.2 0.5 0.4 0.5
Impedance of leg (right) 0.2 1.0 2.0 -1.1 1.1 -0.3 -1.4 -0.7
Leg fat-free mass (left) 0.1 0.3 0.8 0.1 -0.9 -0.7 0.3 -0.1
Trunk fat percentage 0.1 0.5 1.4 1.2 -0.5 0.1 -0.2 0.9
Hand grip strength (right) 0.6 1.8 4.1 1.7 -0.2 1.1 0.8 2.0
Townsend deprivation index at recruitment 1.1 1.6 2.9 1.5 0.0 1.7 1.2 1.3
Current tobacco smoking 0.1 0.2 0.8 -0.3 -0.1 -0.1 0.9 0.4
Average weekly fortified wine intake 0.5 0.6 1.3 0.8 -0.3 0.7 0.4 1.1
Maternal smoking around birth 0.4 0.6 1.3 0.5 -0.1 0.8 0.8 1.1
Fed-up feelings 0.2 0.4 0.9 0.5 -0.7 -1.0 0.2 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.3 1.7 1.2 -1.0 1.1 0.9 1.3
Relative age voice broke 0.5 0.8 3.3 -0.2 1.8 0.3 -0.7 0.4
Taking other prescription medications 2.5 3.9 6.8 2.6 -2.6 1.3 1.3 1.7
Age when periods started (menarche) 0.4 0.9 1.5 1.2 -1.2 0.1 -1.2 -0.5
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.1 0.8 -1.5 -0.1 0.4 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.1 -0.1 0.5 0.9 1.0 0.9
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.6 0.7 1.3 0.9 0.7 0.9
Qualifications: CSEs or equivalent 1.7 2.3 5.2 -2.3 1.6 -1.5 -0.5 -1.0
Serious illness, injury or assault to yourself 0.5 0.6 1.7 0.5 -0.5 0.4 0.7 1.3
High blood pressure 0.4 1.2 2.6 1.0 -0.6 -1.5 -1.6 -0.2
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.9 0.7 -0.6 0.4 0.9 -0.1
Multivitamins +/- minerals 1.2 1.6 2.4 1.2 -1.5 1.5 0.9 1.0
Stomach or abdominal pain in last month 0.1 0.2 0.4 0.4 0.1 0.0 0.6 0.6
Supplements: Glucosamine 0.2 0.3 0.4 0.0 -0.6 0.6 -0.6 0.5
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.0 0.2 -1.0 -0.9 -0.1 -0.9
Medication: Atenolol 0.5 0.7 1.9 1.1 -1.4 -0.2 -0.1 0.4
Medication: Levothyroxine sodium 0.5 0.9 1.9 0.9 -0.6 0.9 1.4 0.7
Sitting height 0.5 3.6 5.2 -1.8 1.8 -1.6 -2.3 -1.9
Chronic bronchitis/emphysema (father) 6.1 7.2 14.7 3.8 -0.8 3.3 1.8 2.5
High blood pressure (mother) 1.3 1.8 5.8 0.5 -2.4 -1.4 -0.8 -0.8
Body mass index (BMI) 0.6 2.4 4.2 2.1 -1.6 1.0 1.2 1.7
Impedance of leg (left) 0.2 1.0 2.0 -1.0 1.4 -0.0 -1.4 -0.3
Leg predicted mass (left) 0.0 0.3 0.8 0.2 -0.9 -0.6 0.4 0.1
Trunk fat mass 0.1 0.6 1.6 1.3 -0.8 0.1 -0.1 0.9
Waist circumference 0.4 1.3 3.4 1.3 -1.8 0.1 1.0 0.8
Number of incorrect matches in round 0.2 0.3 1.0 -0.5 0.4 -0.5 -0.2 -1.0
Past tobacco smoking 2.4 4.5 8.1 -2.9 1.9 -2.3 -1.5 -1.8
Alcohol usually taken with meals 0.1 0.2 0.7 -0.8 0.2 0.2 -0.3 0.2
Nervous feelings 0.5 0.9 2.0 -0.8 -1.4 0.4 1.3 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.3 -0.0 0.5 -0.2 1.1 -0.0
Hearing difficulty/problems with background noise 0.9 1.4 5.1 0.1 -2.2 -0.7 -0.4 -1.0
Hair/balding pattern: Pattern 2 0.4 0.5 1.6 -0.4 1.3 -0.3 -0.7 -0.2
Had menopause 0.2 0.2 0.4 0.6 -0.6 -0.2 0.3 -0.3
Had other major operations 0.3 0.4 0.7 -0.7 -0.8 -0.8 -0.1 -0.1
Forced vital capacity (FVC) 0.4 1.4 5.1 -1.3 2.3 -0.4 0.3 0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 -1.2 1.3 -0.2 -0.1 0.1
Ever unenthusiastic/disinterested for a whole week 3.7 4.5 6.7 2.4 -0.4 2.2 2.2 2.6
Qualifications: None of the above 1.5 3.2 5.7 2.3 -1.2 1.1 2.4 1.5
Financial difficulties in last 2 years 0.2 0.3 0.9 -1.0 0.4 -0.1 -0.5 0.1
Mouth/teeth dental problems 0.9 1.5 3.4 -0.7 1.3 -1.3 -0.3 -1.8
Heart attack 0.4 0.5 1.5 1.2 0.1 0.7 -0.5 0.5
Allergy 0.8 1.9 4.1 -2.0 1.3 -1.3 -1.2 -0.9
Pain all over the body in last month 0.2 0.2 0.6 0.6 0.0 0.1 -0.2 0.8
Diabetes (self-reported) 0.1 0.2 0.3 0.5 0.2 -0.3 0.5 -0.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.4 0.3 -0.6 0.4 0.7 0.1
Medication: Ramipril 1.3 1.6 3.2 1.8 -1.0 1.1 -0.5 1.6
Medication: Simvastatin 1.8 2.7 8.4 2.9 -0.9 1.4 0.0 1.5
Fluid intelligence score 0.1 0.2 0.9 -0.9 0.1 0.0 0.2 0.5
Illnesses of siblings 1.1 1.5 4.1 -2.0 -0.1 -1.4 -0.4 -1.1
Neuroticism score 0.7 1.4 6.0 0.6 -2.4 -0.1 0.9 -0.2
Weight 0.1 0.6 1.1 1.0 -1.0 0.1 0.6 0.9
Impedance of arm (right) 0.3 1.2 2.1 -0.9 1.4 -0.7 -1.4 -0.9
Arm fat percentage (right) 0.3 1.1 2.7 1.6 -1.2 0.3 0.4 1.1
Trunk fat-free mass 0.1 0.4 1.2 0.4 -1.1 -0.2 0.8 -0.1
Hip circumference 0.1 0.5 1.4 1.2 -0.8 0.1 -0.1 0.5
Time employed in main current job 0.3 0.4 1.1 -0.6 1.0 -0.4 0.4 0.3
Alcohol intake versus 10 years previously 0.5 0.8 3.0 -0.2 1.7 -0.5 -0.8 0.1
Father’s age at death 0.3 0.4 0.8 0.7 -0.8 0.3 0.9 -0.4
Worrier / anxious feelings 1.7 3.3 7.7 1.4 -2.8 1.4 1.5 1.6
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 4.6 1.4 -2.1 -0.4 0.3 -0.7
Falls in the last year 0.2 0.3 0.5 0.4 -0.6 0.3 -0.7 0.5
Hair/balding pattern: Pattern 3 0.7 1.1 4.3 -0.8 -2.1 -0.1 0.5 0.4
Number of live births 1.0 1.4 2.6 0.7 1.5 1.1 1.6 0.9
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 5.2 -2.3 2.2 -1.0 0.0 -0.7
Pulse rate 0.6 0.9 3.1 -0.3 1.0 0.6 1.8 0.5
Happiness 0.5 0.6 1.2 -0.0 -0.6 -1.1 -1.1 -0.7
Noisy workplace 4.2 5.1 13.3 2.3 -3.7 1.6 0.9 2.0
Qualifications: A levels/AS levels or equivalent 1.3 3.0 5.8 -2.4 0.5 -1.0 -2.1 -1.8
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 3.6 -1.6 1.9 -0.1 -0.1 -0.3
Mouth/teeth dental problems: Dentures 4.5 7.6 10.7 2.9 -3.3 2.3 2.2 2.9
Asthma 0.9 1.8 6.9 2.6 -1.2 0.7 0.4 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.8 -0.2 -0.9 -0.1 0.2 -0.6
Medication: Cholesterol lowering 1.0 1.5 4.2 2.0 0.3 1.1 0.1 1.4
Depression (self-reported) 0.7 0.8 1.6 0.2 -1.3 0.5 1.1 1.1
Medication: Lansoprazole 0.9 1.0 1.8 -0.8 -0.3 -1.0 -1.1 -1.3
Prospective memory result 0.2 0.2 0.8 -0.2 0.2 -0.0 -0.4 -0.9
Lung cancer (father) 1.3 1.5 2.9 -0.4 0.3 1.5 1.7 1.5
Illnesses of mother 1.5 1.8 7.0 -1.2 2.6 0.0 -0.8 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 6.7 -2.6 2.3 -1.5 -0.9 -1.2
Pulse wave Arterial Stiffness index 0.8 0.9 1.4 0.9 1.2 1.0 -0.9 0.9
Impedance of arm (left) 0.4 1.9 4.7 -1.1 2.2 -0.7 -1.3 -1.0
Arm fat mass (right) 0.4 1.5 2.8 1.7 -1.5 0.5 0.8 1.3
Trunk predicted mass 0.1 0.5 1.5 0.5 -1.2 -0.1 0.9 0.0
Standing height 0.2 1.8 2.7 -1.6 0.9 -1.6 -1.0 -1.4
Length of working week for main job 0.8 0.9 2.9 1.7 -1.1 0.5 0.1 0.4
Exposure to tobacco smoke at home 0.2 0.3 0.4 0.6 0.2 -0.6 -0.6 -0.4
Breastfed as a baby 0.4 0.5 2.1 -0.1 1.5 0.3 -0.0 -0.5
Tense / ‘highly strung’ 0.8 1.3 2.6 0.1 -1.6 0.9 1.6 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.8 -0.2 -0.9 0.2 1.3 0.6
Hair/balding pattern: Pattern 4 0.2 0.5 1.3 -0.3 0.7 -0.2 -1.1 -0.8
Birth weight of first child 0.0 0.0 0.1 -0.3 0.0 0.0 -0.3 -0.1
Peak expiratory flow (PEF) 1.5 3.5 7.7 -2.8 2.1 -1.8 -0.2 -1.5
Pulse wave reflection index 1.0 1.3 2.3 1.3 -0.7 1.1 -0.8 1.5
Ever highly irritable/argumentative for 2 days 3.4 4.1 6.4 2.0 -0.1 2.3 2.5 2.2
Loud music exposure frequency 0.6 0.6 1.4 -0.9 0.8 -0.1 -1.2 -0.4
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 3.8 -1.9 0.4 -0.2 0.2 -0.6
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.9 -1.1 1.4 0.2 -1.1 -0.5
Blood clot in the leg (DVT) 0.2 0.3 0.6 -0.7 0.5 0.2 -0.2 0.8
Medication: Paracetamol 0.5 0.8 2.2 -0.8 0.0 -1.5 -0.7 -0.8
Headache pain in last month 0.3 0.5 1.0 0.1 0.9 1.0 -0.1 0.7
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 5.8 -2.4 -0.1 -0.6 0.2 -1.2
Glaucoma (self-reported) 0.3 0.4 0.6 0.7 0.6 0.6 0.5 0.7
Gout (self-reported) 1.3 1.7 3.2 1.7 -1.8 1.0 0.8 0.8
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 2.9 1.6 -0.8 1.5 1.7 1.6
Medication: Amlodipine 1.1 1.5 4.3 1.2 -0.1 1.3 0.1 2.1
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.7 0.2 0.0 -0.3 1.3 -1.2
Birth weight 0.6 1.3 1.9 -1.0 1.3 -1.4 -0.5 -1.3
Chronic bronchitis/emphysema (mother) 1.4 1.6 2.7 1.3 -0.7 1.2 1.6 1.2
High blood pressure (siblings) 0.7 1.1 4.2 2.1 -0.7 0.6 -0.0 0.5
Forced vital capacity (FVC), Best measure 0.6 2.1 6.8 -1.7 2.6 -0.6 -0.4 -0.3
Body fat percentage 0.3 1.0 2.4 1.6 -1.0 0.4 -0.0 1.2
Leg fat percentage (right) 0.5 1.8 3.6 1.9 -1.9 0.5 -0.0 1.3
Arm fat-free mass (right) 0.1 0.5 1.4 0.4 -1.2 -0.2 0.8 0.1
Exposure to tobacco smoke outside home 0.5 0.6 1.0 1.0 -1.0 0.7 -0.7 0.5
Comparative body size at age 10 1.9 5.1 16.3 4.0 -1.4 1.4 1.3 1.9
Number of full brothers 1.1 1.4 2.6 0.8 -1.2 1.1 1.1 1.6
Worry too long after embarrassment 0.5 0.8 2.4 0.8 -1.6 0.7 0.7 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.7 3.5 5.2 1.0 -2.0 1.9 2.3 2.0
Wheeze or whistling in the chest in last year 2.5 4.5 10.0 3.0 -3.2 1.1 1.5 0.4
Number of children fathered 0.7 0.8 1.6 -0.9 0.6 -1.1 -1.3 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 0.1 -0.1 0.1 0.3 -0.1
Age at first live birth 0.2 0.4 1.6 -0.4 -0.1 0.0 -1.3 0.0
Pulse wave peak to peak time 1.0 1.2 1.7 -1.2 -0.9 -1.2 0.7 -1.3
Health satisfaction 0.4 0.5 1.9 0.6 -1.4 -0.2 0.4 -0.1
Shortness of breath walking on level ground 1.2 1.4 2.5 1.6 -0.8 1.2 0.9 1.2
Qualifications: College or University degree 0.3 1.1 2.4 -1.5 -0.3 -0.7 0.4 -1.5
Eye problems/disorders: None of the above 3.9 4.6 8.0 -1.6 0.6 -2.3 -2.8 -2.6
Mouth/teeth dental problems: Loose teeth 1.6 1.9 2.6 1.0 -1.4 1.1 1.6 1.6
Emphysema/chronic bronchitis 3.5 3.9 4.9 2.1 -1.9 2.2 1.9 1.8
Medication for pain relief, constipation, heartburn 0.1 0.1 0.3 -0.4 0.0 0.5 0.5 0.3
Neck or shoulder pain in last month 0.4 0.5 2.3 -0.3 1.5 -0.3 0.0 -0.4
Medication: Blood pressure 0.5 0.8 2.8 1.7 0.2 0.3 -0.1 1.1
Angina (self-reported) 0.1 0.2 0.5 0.7 -0.7 0.0 -0.0 -0.2
Migraine (self-reported) 0.7 0.9 2.7 1.0 0.6 -0.2 -1.7 -0.4
Medication: Ibuprofen 0.2 0.2 1.1 -0.1 -1.0 -0.1 0.1 -0.2
Medication: Allopurinol 0.3 0.3 0.9 0.6 -0.9 0.2 0.5 0.3
Medication: Omeprazole 0.6 0.7 2.0 -0.3 -1.4 -0.6 -0.4 -0.9
Medication: Seretide 50 evohaler 2.7 3.1 5.8 2.4 -1.9 1.8 1.5 0.6
Mean time to correctly identify matches 0.3 0.6 2.6 -1.6 -0.2 -0.1 0.5 -0.2
Heart disease (mother) 0.2 0.2 0.5 0.6 -0.1 0.4 0.2 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.6 -0.8 -0.8 -0.2 -0.5 0.3
Whole body fat mass 0.2 0.9 2.3 1.5 -1.1 0.3 0.0 1.1
Leg fat mass (right) 0.5 1.9 3.4 1.9 -1.8 0.5 0.3 1.5
Arm predicted mass (right) 0.1 0.4 1.1 0.5 -1.0 -0.2 0.6 0.1
Pulse rate, automated reading 0.3 0.9 2.2 0.9 0.5 1.0 1.5 0.6
Alcohol intake frequency. 1.1 2.4 4.8 2.2 -0.4 1.5 1.6 1.5
Comparative height size at age 10 0.1 0.4 1.1 -0.4 0.3 -0.6 -1.1 -0.5
Number of full sisters 0.9 1.1 3.5 -0.0 1.9 -0.6 -1.1 -0.7
Suffer from ‘nerves’ 0.1 0.2 0.5 -0.4 -0.7 0.2 0.5 0.2
Overall health rating 0.0 0.1 0.3 0.5 0.3 0.1 0.0 -0.1
Chest pain or discomfort 0.3 0.4 1.6 0.6 -0.1 0.1 -1.3 0.1
Had major operations 0.5 0.5 2.6 0.2 0.1 -0.1 -1.6 -0.3
Age at last live birth 0.6 0.9 1.2 0.9 -0.9 1.0 -0.5 1.1
Family relationship satisfaction 0.5 0.6 1.3 1.1 -1.1 0.2 0.0 0.7
Leg pain on walking 2.1 2.6 4.0 1.1 -1.4 1.7 2.0 1.8
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.6 -0.5 0.8 0.4 -0.3 0.8
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.6 -0.4 -0.6 -0.8 -0.0 -0.7
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.3 -0.8 1.0 -1.0 0.1 -1.1
Medication: Aspirin 0.3 0.4 1.3 1.1 0.2 0.0 -0.9 0.3
Supplements: Vitamin C 3.3 3.8 7.8 -2.8 2.6 -1.4 -1.0 -1.3
Knee pain experienced in last month 0.2 0.3 1.0 -1.0 -0.0 -0.5 -0.0 -0.2
Hypertension (Self-reported) 0.4 1.1 2.1 1.1 -0.6 -1.3 -1.4 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.2 -0.2 -1.3 -0.8 -1.3 -1.8
Illnesses of father: Heart disease 1.2 1.7 4.4 2.1 -1.8 0.0 -0.9 0.2
Illnesses of siblings: Diabetes 0.5 0.7 1.8 1.3 -0.9 0.8 0.2 0.3
Smoking status: Previous 3.1 4.6 8.7 2.9 -1.4 2.6 1.6 1.7
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 3.5 -1.5 1.9 -1.5 -0.9 -1.6
Whole body fat-free mass 0.1 0.3 1.0 0.3 -1.0 -0.4 0.6 -0.1
Leg fat-free mass (right) 0.0 0.2 0.6 -0.0 -0.6 -0.8 0.3 -0.1
Arm fat percentage (left) 0.2 0.9 2.5 1.6 -0.9 0.3 0.3 1.1
Average weekly red wine intake 0.3 0.5 1.3 -1.1 0.7 -0.5 -0.3 -0.4
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.3 -0.2 1.5 0.1 0.6 0.4
Mood swings 2.0 3.6 6.7 2.6 -2.2 1.3 1.9 1.0
Loneliness, isolation 0.8 1.2 2.5 -1.5 -0.4 -1.6 0.5 -0.9
Long-standing illness, disability or infirmity 0.9 1.4 3.1 1.8 -1.6 0.6 0.0 1.0
Ever had bowel cancer screening 0.5 0.6 1.0 -0.3 -0.6 -0.9 0.9 -1.0
Diabetes diagnosed by doctor 0.1 0.2 0.5 0.6 -0.1 -0.4 0.1 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.7 0.3 -0.4 0.7 -0.1 1.3
Friendships satisfaction 2.8 3.5 5.7 -1.6 -1.5 -2.4 -1.6 -2.1
Qualifications: nursing, teaching 0.4 0.7 1.5 -0.3 -1.2 0.8 -0.6 0.9
Commuting to job workplace: Walk 1.2 1.3 3.8 0.2 0.2 1.2 1.9 1.1
Eye problems/disorders: Cataract 0.2 0.2 0.4 0.3 0.4 0.6 0.4 0.6
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 1.2 -1.1 -0.4 -1.0 -0.7 -0.9
Medication for cholesterol 1.9 2.9 9.2 -0.2 3.0 1.5 1.3 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 3.7 1.0 0.6 1.1 1.9 1.8
Back pain experienced in last month 0.2 0.3 0.8 0.9 -0.5 0.4 0.5 -0.1
Mineral and other dietary supplements 0.1 0.1 0.4 0.0 0.0 -0.4 0.2 -0.6
Breast cancer (self-reported) 0.9 1.0 2.7 -0.7 0.3 -1.6 -0.4 -1.3
Asthma (self-reported) 0.8 1.5 6.2 2.5 -0.7 0.7 0.6 -0.1
Osteoporosis (self-reported) 0.2 0.2 0.3 0.5 -0.6 -0.5 -0.5 -0.3
Osteoarthritis (self-reported) 0.7 0.9 2.6 0.9 -1.6 0.6 0.5 0.4
Medication: Aspirin 0.4 0.5 1.4 1.1 -0.1 -0.2 -1.2 -0.0
Medication: Gliclazide 1.0 1.2 2.3 1.5 -1.3 0.9 0.5 0.8
Illnesses of father: None of the above (group 1) 1.7 2.1 7.4 -2.7 1.1 -0.7 1.0 -0.6
Smoking status: Current 0.1 0.1 0.2 -0.3 -0.4 -0.4 0.5 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.9 -1.4 1.1 -0.7 -0.2 -0.5
Whole body water mass 0.1 0.3 1.0 0.2 -1.0 -0.4 0.7 -0.1
Leg predicted mass (right) 0.0 0.2 0.6 0.0 -0.5 -0.8 0.3 -0.1
Arm fat mass (left) 0.3 1.1 2.3 1.5 -1.3 0.2 0.6 1.0
Number of self-reported non-cancer illnesses 0.7 1.3 3.3 1.8 -1.6 -0.0 -0.3 0.7
Average weekly champagne plus white wine intake 0.8 1.1 3.6 -1.9 1.2 -0.3 0.5 -0.6
Miserableness 0.6 1.0 1.8 1.4 -1.4 -1.0 0.1 -0.3
Guilty feelings 0.2 0.3 0.6 0.8 -0.3 0.7 0.3 0.2
Wears glasses or contact lenses 0.5 0.6 1.2 0.5 -0.9 0.5 1.1 0.7
Ever taken oral contraceptive pill 0.2 0.2 0.6 -0.7 -0.2 0.1 0.6 -0.1
Hearing aid user 2.8 3.1 5.8 2.0 0.3 2.4 2.0 1.4
Mother’s age at death 0.4 0.5 1.2 -0.3 -1.1 -0.6 -0.2 -0.9
Financial situation satisfaction 0.9 1.1 1.5 -1.1 1.0 -1.2 -0.6 -1.0
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.4 -0.6 0.3 -0.5 -0.6 -0.5
Commuting to job workplace: Public transport 0.3 0.3 0.7 -0.4 0.7 -0.4 0.4 -0.8
Eye problems/disorders: Glaucoma 1.1 1.3 1.9 1.4 -0.3 1.2 1.0 1.3
Medication: Blood pressure 2.0 3.8 13.5 1.5 -3.7 -0.5 -1.7 0.0
Pain type(s) experienced in last month: Hip pain 6.8 8.6 14.6 2.5 1.6 3.1 3.8 3.2
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.6 0.5 -0.4 0.4 -0.1 0.8
High cholesterol (Self-reported) 0.6 1.0 3.2 1.8 -0.5 0.4 1.2 0.2
Medication: Bendroflumethiazide 2.8 4.3 12.0 2.3 -3.5 0.8 -0.8 1.7
Medication: Paracetamol 0.1 0.2 0.6 0.1 -0.7 -0.4 -0.1 0.1
Medication: Lisinopril 0.8 1.0 2.0 1.4 -0.3 0.8 1.4 0.6
Medication: Atorvastatin 1.1 1.3 2.9 1.3 -0.4 1.1 0.7 1.7
Illnesses of father: High blood pressure 0.3 0.4 1.2 1.1 -0.5 -0.8 0.1 0.3
Alcohol drinker status: Never 2.0 2.4 4.6 1.6 -0.2 1.7 2.1 1.5
Ever smoked 0.5 0.9 1.3 0.8 -0.9 0.9 0.8 1.2
Basal metabolic rate 0.1 0.4 1.1 0.4 -1.1 -0.4 0.7 0.1
Leg fat percentage (left) 0.5 1.8 3.8 2.0 -1.7 0.6 0.0 1.5
Arm fat-free mass (left) 0.2 0.9 2.7 0.8 -1.6 0.1 1.1 0.4
Number of operations (self-reported) 1.2 1.7 4.2 1.4 -2.0 0.4 0.4 1.5
Average weekly beer plus cider intake 0.6 0.8 2.5 0.1 -1.6 -0.7 -0.7 -0.9
Irritability 0.7 1.3 2.7 1.6 -1.5 0.6 1.0 0.0
Risk taking 0.3 0.4 1.4 0.3 1.2 0.6 -0.1 0.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.0 0.5 0.8 0.4 -0.9 1.0
Fractured/broken bones in last 5 years 0.5 0.7 1.1 -0.3 -0.7 -0.8 1.0 -1.1
Age started oral contraceptive pill 0.4 0.5 1.8 0.3 -1.3 -0.6 -0.0 -0.6
Diastolic blood pressure, automated reading 0.2 0.5 1.3 -0.1 1.0 -0.6 -1.1 -0.0
Ever depressed for a whole week 4.4 5.4 9.4 1.6 0.1 3.1 2.4 3.0
Unable to work because of sickness or disability 0.8 1.1 1.5 1.0 1.2 1.1 -0.5 1.1
Commuting to job workplace: Cycle 0.2 0.2 0.5 0.7 0.1 0.7 -0.5 0.2
Myopia 0.5 0.7 1.3 -0.7 0.9 -0.6 -1.1 -0.7
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.6 -1.6 0.2 0.5 0.9 -0.5
Cholesterol lowering medication 2.9 4.3 8.4 2.6 -2.9 1.4 1.8 1.0
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 1.2 -0.4 -1.1 -0.8 -0.3 -1.1
Pain experienced in last month 0.1 0.2 0.7 -0.3 -0.8 -0.1 0.0 -0.2
Supplements: Calcium 0.8 0.8 1.9 -0.7 0.6 -1.4 -0.8 -0.9
Basal cell carcinoma (self-reported) 1.0 1.2 4.1 -0.1 0.8 -1.0 -0.6 -2.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.0 1.0 0.2 0.4 -0.7 0.4
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.8 -0.9 0.5 0.4 -0.1 0.6
Heart disease (siblings) 3.9 4.8 9.1 2.4 0.3 3.0 1.4 2.7
Alcohol drinker status: Previous 1.9 2.1 6.5 2.5 -1.9 0.8 0.1 0.3
Pack years of smoking 0.3 0.4 1.4 0.1 -1.2 0.5 0.3 0.6
Impedance of whole body 0.4 2.0 3.4 -1.4 1.8 -0.7 -1.8 -1.0
Leg fat mass (left) 0.5 2.1 4.1 2.0 -1.7 0.6 0.2 1.7
Arm predicted mass (left) 0.2 1.0 2.7 0.8 -1.6 0.1 1.1 0.5