Hub : Genes

VTI1A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0930	0.0420	0.0190	0.002	0.015	0.026	0.027	0.019	1.6e-01	0.0046	0.00036	0.00028	0.0021
2	GTEx	Esophagus Mucosa	0.1490	0.0530	0.0033	0.077	NA	0.021	NA	0.040	8.2e-06	NA	0.01400	NA	0.0011
3	NTR	Blood	0.0166	0.0081	0.0240	-0.001	0.004	-0.001	0.003	-0.001	8.5e-01	0.0110	0.63000	0.03600	0.7200

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.2	2.0	2.8	-1.7	1.5	0.9
Bipolar Disorder or Schizophrenia	0.2	0.6	0.8	-0.9	0.9	0.5
Depressed Affect (Nagel 2018)	0.6	1.3	3.1	0.4	-0.8	1.8
Depression (Nagel 2018)	0.7	1.1	3.3	1.8	0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.6	2.0	4.9	0.8	-2.2	-0.6
Neuroticism (Nagel 2018)	0.3	0.8	2.0	0.4	-0.3	1.4
Schizophrenia (2018)	0.0	0.0	0.0	0.1	-0.1	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.9	1.3	-0.7	-1.2	-0.9
Worry (Nagel 2018)	0.3	0.7	1.1	1.1	0.6	0.8
Alzheimer’s Disease (in mother)	1.9	2.3	5.5	-1.1	0.2	2.3
Alzheimer’s Disease (in father)	1.8	1.9	3.0	1.7	1.6	0.6
Alzheimer’s Disease (including proxy)	1.5	2.2	3.8	0.2	1.6	1.9
Crohns Disease (2017)	0.2	0.5	0.9	-1.0	0.2	-0.7
Irritable Bowel Disease (IBD)	0.3	0.8	1.6	-0.2	-1.3	-0.9
Ulcerative Colitis (UC)	0.9	1.7	4.6	0.4	-2.2	-0.4
Major Depression (MDD)	0.3	0.4	0.8	-0.5	0.9	0.2
Reaction Time	0.5	0.9	2.5	0.0	-1.6	0.2
Verbal and Numeric Reasoning (VNR)	1.1	2.6	4.8	0.5	-1.7	-2.2
Breast Cancer	4.1	9.9	29.2	0.2	-0.7	5.4
Ovarian Cancer	0.6	0.8	1.4	1.0	0.4	-1.2
Prostate Cancer	1.3	1.8	2.8	0.6	1.5	-1.7
Age at First Birth	0.4	0.5	0.9	-0.9	-0.7	0.5
Bipolar Disorder (2011)	2.1	2.0	3.0	-1.5	-0.8	1.7
Body Mass Index (BMI) (2010)	1.2	1.7	4.7	0.3	-0.5	2.2
Coronary Artery Disease (CAD)	0.3	0.4	0.5	-0.7	-0.7	-0.5
Crohns Disease (2012)	0.2	0.3	0.7	-0.0	0.8	-0.3
Mean Putamen Volume	0.3	0.3	0.8	-0.2	0.9	0.4
Fasting Glucose	2.4	2.9	6.6	1.0	1.0	-2.6
HbA1C	3.9	4.3	7.8	1.0	2.1	-2.8
HDL Cholesterol	0.6	1.0	1.7	-1.3	0.7	-0.8
LDL Cholesterol	2.3	3.7	10.8	-3.3	0.2	-0.5
Lupus	0.9	1.4	2.3	1.3	1.5	0.5
Neuroticism (2016)	1.0	1.4	3.7	0.4	-0.5	1.9
Primary Biliary Cirrhosis	0.2	0.2	0.3	-0.5	-0.4	0.5
Rheumatoid Arthritis	0.3	0.4	1.0	-0.2	1.0	-0.4
Schizophrenia (2014)	0.2	0.5	1.0	-1.0	-0.6	0.5
Triglycerides	0.6	1.0	1.4	1.0	-0.9	-1.2
Type 2 Diabetes (T2D) (2012)	8.5	9.8	29.4	-0.2	-0.3	-5.4
Ulcerative Colitis	0.4	0.6	1.5	0.3	-1.2	-0.4
Blood Eosinophil Count	0.0	0.4	0.8	0.9	0.2	0.5
Blood Platelet Count	0.2	2.5	4.5	0.2	1.7	-2.1
Blood Red Count	0.4	3.9	10.3	3.2	0.8	0.8
Blood White Count	1.3	9.7	28.5	5.3	0.1	-0.8
Heel T-Score	1.1	8.4	24.5	0.3	-0.9	-5.0
BMI	3.6	20.7	39.6	3.6	-3.1	6.3
Height	0.3	5.0	10.3	3.2	1.9	-1.1
Waist Hip Ratio (WHR)	1.5	6.6	18.4	-1.1	-0.3	-4.3
Systolic Blood Pressure	1.2	5.8	7.8	-2.0	2.4	-2.8
Smoking Status	0.3	0.7	1.3	-0.0	0.9	-1.1
Allergy or Eczema	0.5	1.3	2.4	-0.5	-1.1	-1.5
Cardiovascular Disease	0.1	0.3	0.9	1.0	-0.2	0.2
Hypothyroidism (self reported)	1.2	2.7	4.2	2.0	1.8	0.7
Respiratory disease	0.6	1.4	3.2	-0.4	-1.8	0.9
Type 2 Diabetes (T2D) (2018)	18.5	34.7	102.0	0.6	-1.3	-10.1
Lung FEV1/FVC ratio	0.1	0.3	0.6	-0.1	0.8	-0.5
Lung FVC	0.3	1.6	4.8	2.2	-0.3	-0.1
Neuroticism	0.2	0.4	1.1	0.4	-0.0	1.0
Chronotype (morning person)	0.7	1.6	2.8	0.4	1.4	-1.7
Hair Pigment	0.1	3.0	6.2	2.5	0.7	1.5
Tanning	0.1	1.2	2.0	1.2	-0.5	1.4
Hand grip strength (left)	0.1	0.4	1.0	0.3	1.0	0.3
Number of treatments/medications taken	0.4	0.7	1.6	0.8	-0.1	-1.2
Average weekly spirits intake	0.4	0.5	1.5	-1.2	0.1	0.2
Sensitivity / hurt feelings	0.8	1.4	2.7	1.1	0.5	1.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	0.6	-0.4	0.3
Hearing difficulty/problems: Yes	0.5	0.7	1.7	-0.7	-1.3	0.2
Relative age of first facial hair	0.4	0.7	2.0	1.4	0.5	0.0
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	4.8	-2.2	-0.3	1.1
Ever used hormone-replacement therapy (HRT)	4.3	5.5	8.3	0.8	2.7	-2.9
Ever had hysterectomy (womb removed)	3.2	3.6	8.6	2.9	0.0	-1.5
Systolic blood pressure, automated reading	0.5	1.4	2.8	-0.7	1.7	-0.9
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	5.5	-1.4	-0.8	-2.4
Angina	1.7	2.2	4.2	-1.5	0.5	-2.0
Medication for hormone replacement therapy	3.8	4.2	8.8	2.0	3.0	-0.0
Vitamin and mineral supplements	0.7	0.9	1.2	1.1	-0.8	1.0
Supplements: Zinc	0.3	0.3	0.7	-0.1	-0.3	-0.8
Medication: Co-codamol	0.8	0.9	1.1	1.0	0.8	-1.1
Medication: Metformin	15.6	21.9	63.4	-0.4	-1.5	-8.0
Diabetes (father)	8.4	10.4	30.2	0.3	-0.9	-5.5
Diabetes (mother)	9.3	11.9	34.9	0.2	-0.9	-5.9
Severe depression (siblings)	1.5	1.7	2.9	1.7	-1.0	1.0
Pack years adult smoking proportion	0.7	1.1	2.8	1.7	-0.6	0.4
Impedance of leg (right)	0.4	2.0	5.5	-0.5	0.4	-2.3
Leg fat-free mass (left)	1.4	7.5	18.6	1.5	-1.3	4.3
Trunk fat percentage	2.2	8.8	17.2	2.3	-2.0	4.1
Hand grip strength (right)	0.3	0.7	1.4	0.2	1.2	0.8
Townsend deprivation index at recruitment	1.5	2.1	4.2	-2.0	0.1	1.4
Current tobacco smoking	0.5	0.9	1.5	-0.2	-1.0	-1.2
Average weekly fortified wine intake	0.8	0.9	2.2	-0.1	1.5	-0.7
Maternal smoking around birth	0.1	0.2	0.4	0.4	0.1	0.6
Fed-up feelings	1.6	2.9	6.5	-0.9	-1.2	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.1	1.0	-0.5	-0.9
Relative age voice broke	0.5	0.7	1.2	1.1	1.0	-0.2
Taking other prescription medications	0.3	0.4	0.8	-0.5	-0.5	-0.9
Age when periods started (menarche)	0.2	0.6	0.9	0.4	0.8	-1.0
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.6	1.1	-1.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	4.3	0.2	-0.6	-2.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.5	-0.7	-0.6	0.4
Qualifications: CSEs or equivalent	0.3	0.4	1.0	0.3	1.0	-0.2
Serious illness, injury or assault to yourself	1.4	1.7	4.0	-0.5	1.0	-2.0
High blood pressure	0.3	0.8	1.9	1.4	-0.8	-0.1
Hayfever, allergic rhinitis or eczema	0.9	2.1	3.3	-1.7	-0.2	-1.8
Multivitamins +/- minerals	0.8	1.0	1.9	-1.4	1.1	-0.1
Stomach or abdominal pain in last month	2.1	2.6	5.6	1.3	-2.4	-0.7
Supplements: Glucosamine	0.1	0.1	0.2	-0.0	0.5	0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	0.6	-0.5	0.0
Medication: Atenolol	0.3	0.3	0.5	-0.6	-0.4	0.7
Medication: Levothyroxine sodium	1.7	2.8	4.4	2.1	1.7	1.1
Sitting height	0.0	0.1	0.1	-0.4	0.3	0.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	0.6	1.3	-0.2
High blood pressure (mother)	0.3	0.4	0.7	-0.1	-0.7	0.9
Body mass index (BMI)	3.6	15.3	34.6	2.4	-2.3	5.9
Impedance of leg (left)	0.4	2.0	4.9	-0.6	0.9	-2.2
Leg predicted mass (left)	1.4	7.6	18.8	1.5	-1.3	4.3
Trunk fat mass	2.8	11.9	25.1	2.5	-2.0	5.0
Waist circumference	3.7	13.6	30.1	1.6	-2.9	5.5
Number of incorrect matches in round	1.1	1.9	5.3	0.1	0.6	2.3
Past tobacco smoking	0.2	0.3	0.9	-0.2	-0.9	-0.2
Alcohol usually taken with meals	0.7	1.2	2.3	0.3	-1.5	-1.1
Nervous feelings	0.9	1.6	2.1	1.4	1.4	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.2	1.1	1.0	0.6
Hearing difficulty/problems with background noise	0.7	1.1	1.5	-0.7	-1.2	-1.1
Hair/balding pattern: Pattern 2	1.0	1.3	2.2	-1.5	-0.9	0.9
Had menopause	2.0	2.6	4.0	-1.5	2.0	-1.2
Had other major operations	0.6	0.8	1.2	0.2	-1.0	-1.1
Forced vital capacity (FVC)	0.4	1.6	4.0	2.0	-0.9	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.6	0.5	-0.4	-2.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.6	1.3	0.9	-0.2
Qualifications: None of the above	0.9	1.9	2.2	1.5	1.2	-1.4
Financial difficulties in last 2 years	0.8	1.1	2.4	0.2	-0.9	1.6
Mouth/teeth dental problems	0.6	1.0	1.7	-1.3	0.4	-1.0
Heart attack	0.3	0.4	1.1	0.3	0.3	-1.1
Allergy	0.4	1.0	2.0	0.9	0.5	1.4
Pain all over the body in last month	0.6	0.6	1.8	0.0	-1.3	0.2
Diabetes (self-reported)	13.5	20.9	58.2	-1.0	-1.8	-7.6
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.8	0.0	-1.1	-1.9
Medication: Ramipril	0.2	0.3	0.4	0.4	0.5	-0.6
Medication: Simvastatin	0.4	0.6	1.8	0.0	-0.2	-1.4
Fluid intelligence score	1.1	2.3	5.2	0.8	-2.3	-1.0
Illnesses of siblings	1.7	2.3	6.6	-0.2	2.6	0.6
Neuroticism score	0.5	1.1	3.0	0.1	-0.6	1.7
Weight	2.7	13.3	29.7	2.7	-1.7	5.5
Impedance of arm (right)	1.6	7.6	21.5	-0.6	1.0	-4.6
Arm fat percentage (right)	2.5	9.8	18.9	2.2	-2.3	4.3
Trunk fat-free mass	1.0	5.6	14.3	1.2	-1.0	3.8
Hip circumference	5.0	21.3	49.0	2.9	-2.6	7.0
Time employed in main current job	0.9	1.1	1.5	1.0	0.8	-1.2
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.5	-0.1	-0.4
Father’s age at death	0.7	1.0	2.4	-0.7	-0.2	1.5
Worrier / anxious feelings	3.5	6.6	17.1	0.8	-1.4	4.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.2	0.7	0.5
Falls in the last year	2.3	3.1	6.0	-1.5	-1.1	2.4
Hair/balding pattern: Pattern 3	1.1	1.7	4.9	0.2	2.2	-0.3
Number of live births	0.6	0.9	2.0	0.7	0.5	-1.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.3	1.1	-0.9	-0.1
Pulse rate	2.2	3.7	10.7	0.6	0.2	-3.3
Happiness	1.1	1.3	2.0	0.4	-1.3	1.4
Noisy workplace	2.0	2.5	5.5	2.4	-0.0	1.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.6	0.7	-1.3	1.1
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.5	1.5	0.3	-2.1
Mouth/teeth dental problems: Dentures	1.5	2.5	3.0	1.6	1.3	-1.7
Asthma	0.3	0.6	1.2	-1.1	-0.4	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.1	-0.3	0.2
Medication: Cholesterol lowering	0.7	1.0	2.5	0.4	0.7	-1.6
Depression (self-reported)	0.2	0.3	0.3	-0.6	-0.5	0.5
Medication: Lansoprazole	1.1	1.3	3.3	1.8	-0.6	-0.3
Prospective memory result	0.4	0.5	1.1	-0.4	0.3	1.0
Lung cancer (father)	0.1	0.1	0.2	0.4	-0.1	0.4
Illnesses of mother	0.1	0.1	0.4	0.0	0.6	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.4	0.8	-1.2	0.0
Pulse wave Arterial Stiffness index	1.1	1.3	3.1	-0.1	0.9	-1.8
Impedance of arm (left)	1.8	8.3	23.4	-0.7	1.1	-4.8
Arm fat mass (right)	3.0	12.2	27.0	2.2	-2.2	5.2
Trunk predicted mass	1.0	5.6	14.1	1.3	-1.1	3.8
Standing height	0.1	1.1	1.6	1.0	1.3	-0.8
Length of working week for main job	0.7	0.8	1.5	0.5	1.2	-0.8
Exposure to tobacco smoke at home	0.3	0.4	0.8	0.3	-0.9	0.5
Breastfed as a baby	0.2	0.3	0.7	0.1	0.8	0.2
Tense / ‘highly strung’	0.1	0.2	0.3	-0.6	0.3	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.8	-0.3	0.3	1.4
Hair/balding pattern: Pattern 4	1.2	3.0	6.1	1.4	-0.9	-2.5
Birth weight of first child	0.6	1.1	1.9	0.8	-0.9	-1.4
Peak expiratory flow (PEF)	0.7	1.7	2.7	0.4	-1.5	1.6
Pulse wave reflection index	0.9	1.1	2.6	-0.2	1.6	0.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	1.4	-0.3	-0.1
Loud music exposure frequency	2.2	2.4	3.6	-1.7	1.9	0.8
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.4	0.8	-1.6	1.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.2	-0.1	-1.4	1.8
Blood clot in the leg (DVT)	1.0	1.3	2.2	-1.2	-1.5	-0.4
Medication: Paracetamol	0.1	0.1	0.2	-0.5	-0.2	-0.2
Headache pain in last month	0.2	0.3	0.7	-0.2	-0.9	0.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.2	-1.2	-0.6	1.5
Glaucoma (self-reported)	0.4	0.5	1.2	0.4	0.4	-1.1
Gout (self-reported)	0.3	0.4	1.0	1.0	0.5	0.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	4.7	2.2	1.2	1.3
Medication: Amlodipine	0.1	0.2	0.3	0.6	0.2	-0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.7	0.8	-0.7	-0.8	0.9
Birth weight	1.1	2.3	5.3	1.2	0.4	-2.3
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.0	1.4	-1.2	0.7
High blood pressure (siblings)	2.5	3.6	8.0	-0.7	-2.8	1.5
Forced vital capacity (FVC), Best measure	0.5	1.7	2.8	1.7	-1.4	0.6
Body fat percentage	2.7	10.8	21.3	2.6	-2.0	4.6
Leg fat percentage (right)	4.1	14.8	31.4	2.7	-2.3	5.6
Arm fat-free mass (right)	1.5	7.5	19.6	1.4	-0.9	4.4
Exposure to tobacco smoke outside home	1.3	1.8	3.8	1.9	0.6	1.1
Comparative body size at age 10	0.6	1.6	3.0	1.2	-0.5	1.7
Number of full brothers	2.2	2.7	6.3	2.5	-1.3	-0.6
Worry too long after embarrassment	0.6	1.0	1.4	-1.0	-0.8	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	1.9	-0.6	1.4	1.3
Wheeze or whistling in the chest in last year	0.6	1.0	2.7	0.3	-1.6	0.5
Number of children fathered	0.3	0.4	0.7	-0.1	0.7	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	3.8	4.4	7.3	0.6	2.4	-2.7
Age at first live birth	2.0	3.6	8.0	-2.8	-0.5	1.6
Pulse wave peak to peak time	0.9	1.0	2.4	0.2	-0.8	1.6
Health satisfaction	0.9	1.2	3.4	0.3	-1.8	0.0
Shortness of breath walking on level ground	0.8	1.0	1.8	0.5	-0.9	1.3
Qualifications: College or University degree	1.6	5.1	7.5	-1.9	-2.7	2.1
Eye problems/disorders: None of the above	1.0	1.2	2.5	-0.1	-1.0	1.6
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.3	0.8	0.5	1.5
Emphysema/chronic bronchitis	0.3	0.4	0.9	0.4	0.9	0.2
Medication for pain relief, constipation, heartburn	0.6	1.0	1.7	0.5	1.3	1.0
Neck or shoulder pain in last month	1.6	2.3	3.3	-1.8	-0.9	-1.6
Medication: Blood pressure	0.3	0.6	1.4	1.2	-0.2	-0.5
Angina (self-reported)	1.8	2.4	4.0	-1.6	0.6	-2.0
Migraine (self-reported)	1.7	2.1	4.4	0.4	-1.3	2.1
Medication: Ibuprofen	0.0	0.0	0.0	-0.1	0.0	0.2
Medication: Allopurinol	0.2	0.2	0.5	0.2	0.7	-0.4
Medication: Omeprazole	0.8	0.9	1.7	-1.3	0.8	-0.7
Medication: Seretide 50 evohaler	0.5	0.5	0.7	-0.9	-0.8	0.4
Mean time to correctly identify matches	0.3	0.5	0.8	0.7	-0.9	-0.5
Heart disease (mother)	0.8	1.0	2.7	-0.3	-0.4	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.6	-0.5	-0.7	1.6
Whole body fat mass	3.3	13.8	28.5	3.0	-2.0	5.3
Leg fat mass (right)	4.2	16.5	37.3	2.7	-2.2	6.1
Arm predicted mass (right)	1.5	7.8	19.7	1.6	-1.1	4.4
Pulse rate, automated reading	2.5	7.9	21.1	0.6	1.5	-4.6
Alcohol intake frequency.	2.9	6.7	11.8	1.7	-2.3	3.4
Comparative height size at age 10	0.7	4.0	7.2	2.1	2.7	-0.6
Number of full sisters	0.7	0.9	1.4	-0.8	1.2	-0.8
Suffer from ‘nerves’	0.0	0.1	0.1	-0.2	0.4	0.1
Overall health rating	0.8	1.7	4.4	0.9	-2.1	0.0
Chest pain or discomfort	1.2	1.8	2.8	-1.3	-1.7	-1.0
Had major operations	1.4	1.7	2.6	1.4	1.6	-0.7
Age at last live birth	1.9	2.7	5.6	-2.4	-1.2	1.1
Family relationship satisfaction	0.4	0.5	1.2	0.5	1.1	0.1
Leg pain on walking	0.9	1.1	1.7	-1.3	0.8	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.5	0.4	0.0	1.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.9	1.0	1.4	-0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.5	-0.8	-0.6	1.2
Medication: Aspirin	1.1	1.5	4.1	-0.4	-0.5	-2.0
Supplements: Vitamin C	1.4	1.7	2.3	0.9	1.5	-1.4
Knee pain experienced in last month	0.8	1.2	2.1	0.1	-1.2	1.4
Hypertension (Self-reported)	0.2	0.6	1.3	1.2	-0.7	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	2.5	1.2	-1.6	0.6
Illnesses of father: Heart disease	2.4	3.3	5.9	-0.7	-2.4	1.8
Illnesses of siblings: Diabetes	4.5	5.6	11.2	-0.6	-3.4	-2.3
Smoking status: Previous	0.9	1.3	3.7	0.1	1.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	0.7	0.2	-0.6
Whole body fat-free mass	1.3	7.6	19.3	1.3	-1.3	4.4
Leg fat-free mass (right)	1.2	6.2	15.8	1.4	-1.0	4.0
Arm fat percentage (left)	2.5	9.8	19.4	2.1	-2.3	4.4
Average weekly red wine intake	0.5	0.8	1.3	-0.8	-1.1	-0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	0.2	1.3	0.1
Mood swings	1.0	1.8	3.9	-1.2	0.2	2.0
Loneliness, isolation	1.4	1.9	4.3	0.8	-0.8	2.1
Long-standing illness, disability or infirmity	0.7	1.0	2.7	0.0	0.5	-1.6
Ever had bowel cancer screening	0.7	0.8	1.9	0.7	-1.4	-0.1
Diabetes diagnosed by doctor	17.4	28.6	82.6	-0.9	-1.6	-9.1
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.2	-0.5	0.5	2.0
Friendships satisfaction	0.7	0.9	2.5	0.4	0.1	1.6
Qualifications: nursing, teaching	2.0	3.1	9.3	0.2	-0.1	3.0
Commuting to job workplace: Walk	0.2	0.2	0.4	0.1	0.6	-0.4
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.6	0.4	-0.0
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.3	-0.8	0.0	2.1
Medication for cholesterol	0.4	0.6	1.1	-1.0	-0.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	0.9	-1.0	0.7	-0.9
Back pain experienced in last month	0.2	0.3	0.7	0.2	-0.4	0.8
Mineral and other dietary supplements	0.0	0.0	0.0	0.2	0.0	0.1
Breast cancer (self-reported)	0.8	1.0	2.7	0.5	-0.0	-1.6
Asthma (self-reported)	0.3	0.6	1.1	-1.0	-0.5	0.6
Osteoporosis (self-reported)	0.2	0.2	0.5	0.3	0.7	0.1
Osteoarthritis (self-reported)	0.6	0.8	1.8	-1.4	-0.5	0.4
Medication: Aspirin	2.0	2.6	6.8	-0.9	-0.2	-2.6
Medication: Gliclazide	4.9	5.5	15.7	0.4	-0.8	-4.0
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	0.3	0.2	-0.8
Smoking status: Current	0.6	1.0	1.5	-0.7	-1.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.4	-1.0	-1.1	-1.2
Whole body water mass	1.3	7.4	18.7	1.3	-1.3	4.3
Leg predicted mass (right)	1.2	6.2	15.9	1.3	-1.0	4.0
Arm fat mass (left)	2.9	12.0	25.8	2.3	-2.3	5.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	0.5	0.4	-1.3
Average weekly champagne plus white wine intake	1.2	1.6	4.8	-0.0	0.3	-2.2
Miserableness	1.0	1.7	4.1	-0.7	-0.7	2.0
Guilty feelings	0.5	0.7	1.8	0.1	-0.6	1.3
Wears glasses or contact lenses	2.3	2.6	4.0	-0.6	-2.0	-1.9
Ever taken oral contraceptive pill	0.5	0.6	1.1	-1.0	0.6	0.6
Hearing aid user	0.3	0.3	1.0	-0.1	0.0	-1.0
Mother’s age at death	0.2	0.3	0.5	0.7	0.5	-0.5
Financial situation satisfaction	1.0	1.2	3.2	1.8	0.2	0.7
Tinnitus: Yes, now most or all of the time	1.4	1.7	2.6	-1.6	0.8	-1.3
Commuting to job workplace: Public transport	1.7	2.1	4.4	-2.1	-1.3	-0.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	0.2	0.6	-1.1
Medication: Blood pressure	0.1	0.3	0.4	0.2	-0.7	-0.6
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.7	0.5	-1.1	2.4
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.5	-0.2	1.0	-1.6
High cholesterol (Self-reported)	0.4	0.7	1.5	0.5	0.6	-1.2
Medication: Bendroflumethiazide	0.8	1.2	2.7	1.0	1.6	-0.3
Medication: Paracetamol	0.1	0.2	0.2	-0.5	-0.4	-0.3
Medication: Lisinopril	1.2	1.5	4.2	2.1	0.4	0.5
Medication: Atorvastatin	1.1	1.4	4.0	-0.1	-0.2	-2.0
Illnesses of father: High blood pressure	0.9	1.1	2.1	0.2	1.5	1.1
Alcohol drinker status: Never	1.9	2.3	3.8	0.6	-1.7	1.9
Ever smoked	0.2	0.4	0.7	0.2	0.7	-0.8
Basal metabolic rate	1.6	9.0	22.3	1.7	-1.4	4.7
Leg fat percentage (left)	4.1	14.7	32.9	2.7	-2.0	5.7
Arm fat-free mass (left)	1.8	9.3	22.8	1.7	-1.5	4.8
Number of operations (self-reported)	1.1	1.6	4.2	2.1	0.3	-0.8
Average weekly beer plus cider intake	1.0	1.4	3.1	1.8	1.1	0.2
Irritability	0.1	0.2	0.6	-0.8	-0.1	-0.1
Risk taking	0.2	0.3	0.5	-0.7	-0.6	0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.3	-0.1	-0.7
Fractured/broken bones in last 5 years	0.8	1.1	3.0	-1.7	-0.3	0.4
Age started oral contraceptive pill	0.6	0.8	1.2	-1.1	0.4	1.0
Diastolic blood pressure, automated reading	1.1	3.4	7.1	-0.1	1.7	2.7
Ever depressed for a whole week	0.6	0.8	1.9	0.7	1.4	0.1
Unable to work because of sickness or disability	0.1	0.1	0.2	0.4	-0.3	0.0
Commuting to job workplace: Cycle	0.8	1.0	3.0	0.1	-1.7	-0.2
Myopia	1.6	2.3	6.1	-0.4	-0.8	-2.5
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.2	-1.1	0.5	0.6
Cholesterol lowering medication	1.8	2.6	5.2	-0.5	-1.6	-2.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.9	-0.2	-0.5
Pain experienced in last month	0.8	1.3	2.6	0.7	1.6	-0.9
Supplements: Calcium	0.2	0.2	0.6	-0.2	-0.3	0.8
Basal cell carcinoma (self-reported)	1.0	1.1	1.9	1.1	0.5	-1.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	0.5	0.5	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.5	-0.9	-1.2	-0.2
Heart disease (siblings)	0.5	0.6	1.1	0.7	-0.4	-1.1
Alcohol drinker status: Previous	0.4	0.5	1.0	0.3	1.0	0.7
Pack years of smoking	0.9	1.3	4.0	2.0	-0.2	0.0
Impedance of whole body	1.3	6.7	17.5	-0.7	1.4	-4.2
Leg fat mass (left)	4.1	16.1	38.0	2.6	-1.9	6.2
Arm predicted mass (left)	1.8	9.1	22.4	1.6	-1.5	4.7