TWAS hub - VTN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.320	0.113	0.00450	0.043	NA	0.002	NA	0.015	2.3e-02	NA	0.28000	NA	1.2e-01
2	GTEx	Esophagus Muscularis	0.124	0.045	0.00016	0.086	NA	0.057	NA	0.063	6.9e-06	NA	0.00023	NA	1.1e-04
3	GTEx	Pancreas	0.086	0.041	0.00760	0.095	NA	0.006	NA	0.039	8.0e-05	NA	0.17000	NA	9.1e-03
4	GTEx	Pituitary	0.222	0.097	0.00650	0.212	NA	0.054	NA	0.156	5.0e-06	NA	0.01800	NA	9.7e-05
5	GTEx	Thyroid	0.056	0.026	0.00280	0.052	NA	0.037	NA	0.036	7.9e-05	NA	0.00076	NA	8.9e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Medication: Amlodipine	7.8	10.9	14.0	3.0	3.7	3.6	3.5	2.4
Alcohol intake versus 10 years previously	5.7	8.5	17.6	4.2	2.5	2.3	2.4	2.7
Average weekly red wine intake	5.4	8.0	10.7	-3.1	-2.8	-2.4	-2.5	-3.3
Leg pain on walking	5.1	6.4	8.0	-2.0	-2.7	-2.8	-2.8	-2.2
Mouth/teeth dental problems: Bleeding gums	4.6	5.9	6.8	-2.1	-2.5	-2.6	-2.6	-2.3
Chronic bronchitis/emphysema (father)	3.8	4.4	5.8	1.9	2.2	2.0	2.0	2.4
Ever had stillbirth, spontaneous miscarriage or termination	3.8	4.1	4.7	-2.0	-2.2	-2.1	-2.0	-1.9
Rheumatoid Arthritis	3.5	4.8	5.8	2.4	2.1	2.0	2.1	2.4
Tinnitus: Yes, now most or all of the time	3.5	4.1	6.0	1.7	2.2	1.9	1.8	2.5
Bipolar Disorder (2011)	3.3	3.2	4.3	-1.7	-1.9	-1.6	-1.6	-2.1
Reaction Time	3.2	6.1	10.9	3.3	2.1	2.0	2.2	2.6
Ever had hysterectomy (womb removed)	3.2	3.7	5.1	2.3	1.8	1.9	1.8	1.8
Alcohol drinker status: Previous	3.2	3.7	4.6	2.2	1.9	1.9	2.0	1.5
Systolic blood pressure, automated reading	3.1	8.9	13.8	3.7	3.1	3.0	2.9	2.0
Prospective memory result	3.1	3.8	5.0	-1.5	-2.0	-2.2	-2.2	-1.7
Health satisfaction	3.1	4.1	5.1	-1.7	-2.1	-2.3	-2.3	-1.6
Illnesses of father: None of the above (group 1)	3.1	3.8	4.9	-1.0	-2.1	-2.1	-2.0	-2.2
Medication: Lansoprazole	3.0	3.4	3.7	1.9	1.9	1.7	1.8	1.9
Shortness of breath walking on level ground	2.9	3.4	4.7	1.6	1.9	1.8	1.7	2.2
Mouth/teeth dental problems: Loose teeth	2.8	3.4	4.2	-1.5	-2.0	-2.0	-2.0	-1.6
Pack years adult smoking proportion	2.7	4.2	5.8	2.1	2.0	1.8	1.8	2.4
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	4.3	1.2	2.0	2.0	2.0	2.1
Taking other prescription medications	2.5	3.9	6.3	2.5	1.9	2.0	1.8	1.6
Medication: Cholesterol lowering	2.4	3.7	4.7	-1.0	-2.1	-2.0	-2.2	-2.0
LDL Cholesterol	2.3	3.6	5.1	-0.7	-2.2	-2.3	-2.2	-1.6
Severe depression (siblings)	2.3	2.6	3.8	-0.8	-1.9	-1.7	-1.7	-1.7
Medication: Simvastatin	2.3	3.4	4.2	-1.0	-1.9	-2.0	-2.0	-2.0
Diastolic blood pressure, automated reading	2.2	6.7	7.8	2.6	2.8	2.7	2.6	2.2
Pack years of smoking	2.2	3.3	4.8	2.0	1.8	1.5	1.5	2.2
Systolic Blood Pressure	2.1	10.4	12.5	3.4	3.5	3.4	3.1	2.6
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	3.1	-1.6	-1.6	-1.7	-1.8	-1.3
Length of working week for main job	2.1	2.4	2.6	-1.6	-1.5	-1.6	-1.6	-1.4
Risk taking	2.1	3.1	3.8	-1.2	-2.0	-1.9	-2.0	-1.7
Breast Cancer	2.0	4.8	5.8	-1.7	-2.4	-2.4	-2.3	-2.1
Blood Red Count	2.0	19.5	28.2	-5.3	-4.2	-4.2	-4.2	-4.0
Pulse wave Arterial Stiffness index	2.0	2.4	3.3	1.3	1.6	1.5	1.5	1.8
Mineral and other dietary supplements	2.0	2.8	3.8	1.9	1.6	1.5	1.5	1.7
Medication: Gliclazide	2.0	2.3	3.3	-1.8	-1.4	-1.4	-1.4	-1.4
Lupus	1.9	2.9	3.8	1.9	1.8	1.7	1.6	1.6
Ulcerative Colitis	1.9	2.7	4.7	-1.3	-1.7	-1.5	-1.5	-2.2
Blood White Count	1.9	13.8	16.7	4.1	3.8	3.6	3.5	3.5
Medication: Ramipril	1.9	2.4	3.7	1.9	1.5	1.5	1.4	1.3
Coronary Artery Disease (CAD)	1.8	2.2	2.7	-1.3	-1.4	-1.6	-1.6	-1.4
Neck or shoulder pain in last month	1.8	2.5	4.0	0.9	1.7	1.6	1.6	2.0
Hypertension (Self-reported)	1.8	4.9	8.3	2.9	2.3	2.2	2.2	1.3
Body Mass Index (BMI) (2010)	1.7	2.3	3.0	1.6	1.6	1.3	1.3	1.7
Alcohol usually taken with meals	1.7	2.8	5.0	-2.2	-1.4	-1.3	-1.3	-1.9
Noisy workplace	1.6	1.9	3.5	1.9	1.3	1.0	1.1	1.5
Pulse wave peak to peak time	1.6	1.8	2.4	-1.1	-1.4	-1.3	-1.3	-1.5
Medication: Aspirin	1.6	2.1	2.7	-0.7	-1.6	-1.6	-1.5	-1.6
Alzheimer’s Disease (in father)	1.5	1.6	2.2	1.2	1.3	1.2	1.2	1.5
Maternal smoking around birth	1.5	2.1	3.3	0.4	1.7	1.5	1.4	1.8
Father’s age at death	1.5	2.0	2.7	1.6	1.2	1.2	1.3	1.6
Ever taken oral contraceptive pill	1.5	1.7	3.1	-1.8	-1.2	-1.2	-1.3	-0.8
Alcohol drinker status: Never	1.5	1.8	2.4	-1.1	-1.5	-1.5	-1.5	-1.1
Ever had prostate specific antigen (PSA) test	1.5	1.7	2.1	1.0	1.4	1.4	1.4	1.3
Irritable Bowel Disease (IBD)	1.4	3.3	4.9	-1.3	-1.9	-1.8	-1.7	-2.2
Ulcerative Colitis (UC)	1.4	2.6	4.3	-1.1	-1.7	-1.5	-1.5	-2.1
High blood pressure	1.4	3.8	6.6	2.6	2.0	1.9	1.9	1.1
Happiness	1.4	1.6	2.2	1.3	1.3	1.2	1.1	1.5
Depression (self-reported)	1.4	1.7	2.1	1.4	1.3	1.3	1.2	1.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.1	1.1	1.4	1.2	1.1	1.4
Average weekly champagne plus white wine intake	1.4	1.9	2.2	-0.8	-1.5	-1.4	-1.5	-1.5
High cholesterol (Self-reported)	1.4	2.5	3.5	-1.2	-1.7	-1.8	-1.9	-1.2
Type 2 Diabetes (T2D) (2018)	1.3	2.5	3.4	1.3	1.9	1.6	1.5	1.5
Hearing difficulty/problems: Yes	1.3	1.9	2.7	1.6	1.3	1.5	1.4	1.1
Fed-up feelings	1.3	2.4	3.0	1.4	1.5	1.6	1.6	1.7
Past tobacco smoking	1.3	2.4	3.5	0.6	1.7	1.6	1.5	1.9
Time employed in main current job	1.3	1.5	3.8	-1.9	-0.9	-0.9	-1.0	-1.1
Commuting to job workplace: Walk	1.3	1.4	2.2	-1.2	-1.2	-0.9	-0.9	-1.5
Smoking status: Current	1.3	2.0	3.1	-0.3	-1.8	-1.7	-1.7	-1.1
Ovarian Cancer	1.2	1.6	2.3	-1.5	-1.2	-1.4	-1.2	-1.1
Age at First Birth	1.2	1.8	3.0	0.9	1.3	1.4	1.2	1.7
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.1	1.8	1.1	1.2	1.1	0.8
Hand grip strength (right)	1.2	3.2	3.6	-1.7	-1.9	-1.8	-1.7	-1.7
Wears glasses or contact lenses	1.2	1.4	1.8	1.0	1.3	1.3	1.3	0.9
Hand grip strength (left)	1.1	2.8	3.5	-1.9	-1.7	-1.7	-1.6	-1.6
Medication: Co-codamol	1.1	1.2	1.5	1.2	1.2	1.1	1.1	1.0
Medication: Metformin	1.1	1.5	2.2	1.0	1.5	1.3	1.2	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	2.9	1.7	1.1	1.1	1.1	1.6
Qualifications: A levels/AS levels or equivalent	1.1	2.5	5.3	-2.3	-1.3	-1.2	-1.4	-1.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	2.7	-1.2	-1.6	-1.6	-1.7	-1.2
Osteoporosis (self-reported)	1.1	1.3	2.1	0.8	1.1	1.1	1.1	1.4
Medication: Aspirin	1.1	1.4	1.8	-0.3	-1.4	-1.3	-1.3	-1.4
Ever depressed for a whole week	1.1	1.4	1.6	-1.1	-1.2	-1.2	-1.3	-1.1
Crohns Disease (2017)	1.0	2.3	2.7	-1.2	-1.6	-1.6	-1.4	-1.6
Average weekly fortified wine intake	1.0	1.2	1.6	-0.5	-1.2	-1.3	-1.2	-1.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.3	-1.1	-1.1	-1.0	-1.0	-1.1
Supplements: Glucosamine	1.0	1.4	2.8	-1.7	-0.9	-0.9	-0.9	-1.3
Birth weight of first child	1.0	1.7	2.3	-1.3	-1.4	-1.5	-1.4	-0.9
Exposure to tobacco smoke outside home	1.0	1.4	3.4	1.9	1.0	0.9	0.9	0.9
Medication: Blood pressure	1.0	1.8	3.3	1.8	1.3	1.4	1.3	0.4
Mean time to correctly identify matches	1.0	1.9	5.4	2.3	0.9	0.9	1.0	1.2
Alcohol intake frequency.	1.0	2.3	3.9	1.8	1.3	1.1	1.1	2.0
Breast cancer (self-reported)	1.0	1.2	1.9	1.4	1.0	0.9	0.8	1.3
Blood Platelet Count	0.9	10.9	12.7	-3.2	-3.4	-3.5	-3.6	-2.8
Sitting height	0.9	6.4	10.1	2.0	2.5	2.4	2.5	3.2
Impedance of arm (right)	0.9	4.0	5.7	0.4	2.4	2.4	2.2	1.9
Mouth/teeth dental problems: Dentures	0.9	1.4	2.6	1.2	1.1	1.0	0.9	1.6
Comparative height size at age 10	0.9	5.0	8.5	1.9	2.1	2.0	2.1	2.9
Diabetes diagnosed by doctor	0.9	1.5	1.9	1.4	1.4	1.3	1.2	0.8
Osteoarthritis (self-reported)	0.9	1.1	2.7	-1.6	-0.9	-0.7	-0.7	-1.0
Average weekly beer plus cider intake	0.9	1.4	2.1	1.3	1.1	1.0	1.0	1.4
Vascular/heart problems diagnosed by doctor	0.9	2.3	4.4	-2.1	-1.5	-1.5	-1.5	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.7	1.3	0.9	1.0	1.0	0.9
Alzheimer’s Disease (including proxy)	0.8	1.2	1.7	0.6	1.2	1.3	1.2	1.0
Type 2 Diabetes (T2D) (2012)	0.8	1.0	1.9	0.7	0.9	0.9	0.9	1.4
Smoking Status	0.8	2.0	2.9	0.1	-1.7	-1.6	-1.5	-1.6
Chronotype (morning person)	0.8	1.9	4.1	-2.0	-1.0	-1.2	-1.2	-1.2
Supplements: Zinc	0.8	0.9	2.1	-1.4	-0.7	-0.9	-0.9	-0.5
Current tobacco smoking	0.8	1.3	2.0	-0.2	-1.4	-1.4	-1.4	-0.7
Number of incorrect matches in round	0.8	1.3	2.0	-0.6	-1.2	-1.1	-1.2	-1.4
Qualifications: None of the above	0.8	1.8	2.5	1.5	1.3	1.1	1.1	1.6
Heart attack	0.8	1.0	1.0	-1.0	-0.9	-1.0	-1.0	-1.0
Hair/balding pattern: Pattern 3	0.8	1.2	2.0	-1.4	-1.1	-1.1	-1.0	-0.8
Impedance of arm (left)	0.8	3.7	5.4	0.4	2.3	2.3	2.1	1.8
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.1	-0.0	0.9	0.9	0.8	1.5
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	4.2	-2.0	-0.3	-0.2	-0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	1.9	0.2	-1.3	-1.4	-1.3	-1.2
Medication: Bendroflumethiazide	0.8	1.3	1.5	1.2	1.2	1.2	1.2	0.7
Crohns Disease (2012)	0.7	1.1	1.8	-0.4	-1.1	-1.1	-1.0	-1.4
Number of treatments/medications taken	0.7	1.2	3.0	1.7	0.9	1.0	0.9	0.6
Average weekly spirits intake	0.7	0.8	1.1	-0.6	-1.0	-0.9	-0.9	-1.1
Forced vital capacity (FVC), Best measure	0.7	2.5	4.6	-0.1	1.8	1.5	1.6	2.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.0	-1.0	-0.9	-1.0	-1.0	-1.0
Heart disease (siblings)	0.7	0.9	1.1	-0.7	-1.1	-1.0	-1.0	-0.9
Depressed Affect (Nagel 2018)	0.6	1.2	1.3	1.2	1.1	1.1	1.1	1.2
Prostate Cancer	0.6	0.9	1.5	1.2	0.9	1.0	1.0	0.3
Mean Putamen Volume	0.6	0.7	1.7	-1.3	-0.6	-0.5	-0.6	-0.8
Qualifications: CSEs or equivalent	0.6	0.8	2.1	1.5	0.7	0.7	0.7	0.8
Forced vital capacity (FVC)	0.6	2.3	4.5	-0.5	1.6	1.4	1.4	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	2.7	-0.6	1.6	1.3	1.3	1.6
Suffer from ‘nerves’	0.6	0.9	2.0	1.4	0.7	0.7	0.7	1.0
Mood swings	0.6	1.0	1.8	0.6	1.0	1.0	1.0	1.3
Number of self-reported non-cancer illnesses	0.6	1.1	2.5	1.6	0.8	1.0	0.8	0.8
Medication: Paracetamol	0.6	0.9	1.2	0.8	0.9	0.9	0.9	1.1
Ever smoked	0.6	1.1	1.8	-0.2	-1.3	-1.1	-1.0	-1.3
Basal cell carcinoma (self-reported)	0.6	0.8	1.4	1.2	0.9	0.8	0.7	0.8
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	0.3	0.8	1.0	1.0	0.5
Allergy or Eczema	0.5	1.3	1.9	0.3	1.2	1.3	1.2	1.4
Lung FVC	0.5	2.8	3.9	0.7	2.0	1.8	2.0	1.5
Relative age of first facial hair	0.5	1.0	1.4	-0.7	-1.1	-1.2	-1.2	-0.7
Stomach or abdominal pain in last month	0.5	0.6	1.1	0.6	0.8	0.7	0.7	1.0
Hair/balding pattern: Pattern 2	0.5	0.7	2.9	1.7	0.4	0.5	0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.2	0.1	1.3	1.4	1.5	-0.0
Diabetes (self-reported)	0.5	0.8	1.1	0.8	1.0	1.0	1.0	0.5
Fluid intelligence score	0.5	1.0	1.4	-0.8	-1.2	-1.1	-1.0	-0.9
Number of live births	0.5	0.7	1.2	-1.1	-0.7	-0.7	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.2	-0.9	1.5	1.3	1.3	1.5
Blood clot in the leg (DVT)	0.5	0.6	0.8	-0.9	-0.9	-0.9	-0.8	-0.2
Glaucoma (self-reported)	0.5	0.6	1.0	0.6	0.9	1.0	0.9	0.2
Number of full sisters	0.5	0.6	1.2	0.8	0.7	0.5	0.6	1.1
Family relationship satisfaction	0.5	0.6	1.1	-1.1	-0.8	-0.7	-0.7	-0.5
Smoking status: Previous	0.5	0.8	1.4	-0.1	-1.0	-0.9	-0.8	-1.2
Fractured/broken bones in last 5 years	0.5	0.6	0.8	0.0	-0.9	-0.9	-0.9	-0.8
Blood Eosinophil Count	0.4	2.8	5.4	2.3	1.4	1.5	1.4	1.6
Cardiovascular Disease	0.4	1.3	3.3	1.8	1.0	0.9	0.8	0.8
Hypothyroidism (self reported)	0.4	1.0	1.4	-0.7	-1.2	-1.1	-1.2	-0.6
Respiratory disease	0.4	0.8	1.8	0.6	0.9	0.7	0.6	1.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.1	0.9	0.6	0.6	0.5	1.1
High blood pressure (mother)	0.4	0.6	1.6	1.2	0.8	0.8	0.6	-0.0
Mouth/teeth dental problems	0.4	0.6	1.2	-0.1	0.9	1.1	1.1	0.0
Hair/balding pattern: Pattern 4	0.4	0.9	2.8	-1.7	-0.7	-0.7	-0.8	-0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	0.2	0.9	0.9	0.9	0.5
High blood pressure (siblings)	0.4	0.6	1.2	0.2	1.1	1.0	0.8	0.2
Angina (self-reported)	0.4	0.6	1.7	1.3	0.4	0.3	0.3	0.8
Heart disease (mother)	0.4	0.4	1.3	1.1	0.4	0.4	0.4	0.7
Had major operations	0.4	0.5	0.6	0.7	0.8	0.7	0.7	0.6
Medication: Blood pressure	0.4	0.7	1.1	0.9	1.0	0.8	0.8	0.7
Medication: Atorvastatin	0.4	0.5	1.2	-1.1	-0.6	-0.6	-0.7	-0.2
Impedance of whole body	0.4	2.0	3.1	-0.3	1.7	1.8	1.6	1.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.2	0.5	0.5	0.5	1.0
Waist Hip Ratio (WHR)	0.3	1.4	2.6	-1.0	-1.0	-1.0	-1.1	-1.6
Angina	0.3	0.4	1.5	1.2	0.2	0.1	0.1	0.6
Trunk fat percentage	0.3	1.1	2.1	1.4	1.0	0.8	0.8	1.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	1.2	-0.1	0.1	0.2	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.5	1.0	-0.1	0.8	0.8	0.7	1.0
Multivitamins +/- minerals	0.3	0.4	1.0	0.3	0.6	0.4	0.4	1.0
Had menopause	0.3	0.3	0.4	0.6	0.6	0.5	0.6	0.5
Financial difficulties in last 2 years	0.3	0.4	0.8	0.9	-0.6	-0.7	-0.7	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	0.9	-0.1	-0.9	-0.9	-0.9	-0.4
Pulse rate	0.3	0.5	0.5	-0.7	-0.7	-0.6	-0.7	-0.7
Lung cancer (father)	0.3	0.3	0.5	0.3	0.7	0.7	0.7	0.4
Medication: Paracetamol	0.3	0.4	0.8	0.9	0.5	0.4	0.5	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	-0.1	-0.6	-0.7	-0.7	-0.9
Age at first live birth	0.3	0.6	1.1	-1.0	-0.6	-0.5	-0.5	-1.1
Medication for pain relief, constipation, heartburn	0.3	0.5	2.1	-1.4	-0.2	-0.3	-0.3	-0.4
Medication: Ibuprofen	0.3	0.4	0.7	-0.9	-0.6	-0.4	-0.4	-0.7
Long-standing illness, disability or infirmity	0.3	0.5	2.3	1.5	-0.0	0.2	0.1	0.2
Qualifications: nursing, teaching	0.3	0.5	1.1	-1.0	-0.5	-0.3	-0.4	-1.1
Medication for cholesterol	0.3	0.4	0.7	-0.8	-0.6	-0.4	-0.4	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	1.0	0.3	0.3	0.3	0.8
Back pain experienced in last month	0.3	0.5	1.2	1.1	0.5	0.4	0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.2	-0.4	1.1	0.9	0.9	0.7
Commuting to job workplace: Cycle	0.3	0.4	0.7	0.8	0.3	0.5	0.4	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	-0.7	-0.6	-0.7	-0.6	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	-0.5	-1.1	-1.0	-1.0	-0.5
Neuroticism (Nagel 2018)	0.2	0.5	1.2	1.1	0.6	0.5	0.5	0.6
Major Depression (MDD)	0.2	0.3	0.8	-0.9	-0.5	-0.4	-0.4	0.0
HbA1C	0.2	0.2	0.4	-0.1	-0.6	-0.4	-0.4	-0.6
Neuroticism (2016)	0.2	0.3	0.6	-0.7	-0.4	-0.4	-0.5	-0.5
Triglycerides	0.2	0.3	0.6	0.2	0.7	0.8	0.7	0.2
Heel T-Score	0.2	1.5	2.9	0.0	0.9	1.3	1.4	-1.7
Hair Pigment	0.2	7.0	8.1	2.3	2.7	2.6	2.7	2.8
Diabetes (father)	0.2	0.2	0.5	0.3	0.5	0.4	0.3	0.7
Townsend deprivation index at recruitment	0.2	0.2	0.4	0.2	0.5	0.4	0.5	0.6
Serious illness, injury or assault to yourself	0.2	0.3	0.4	0.3	-0.6	-0.6	-0.6	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.3	0.2	0.5	0.6	0.6	0.6
Trunk fat mass	0.2	0.9	2.0	1.4	0.7	0.5	0.6	1.1
Hearing difficulty/problems with background noise	0.2	0.4	0.6	0.3	0.6	0.8	0.7	0.6
Had other major operations	0.2	0.2	0.7	0.0	0.4	0.3	0.4	0.8
Hip circumference	0.2	0.6	1.9	1.4	0.3	0.1	0.1	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.4	0.4	0.5	0.5	0.4
Standing height	0.2	2.1	6.5	0.4	1.2	1.0	1.1	2.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.1	-0.4	-0.6	-0.7	-0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	1.2	-1.1	-0.0	0.1	0.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	-0.5	0.4	0.2	0.3	1.0
Leg fat percentage (right)	0.2	0.8	1.1	-0.1	-1.0	-1.1	-1.1	-0.9
Qualifications: College or University degree	0.2	0.7	1.6	-1.3	-0.6	-0.6	-0.6	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.3	-0.4	-0.5	-0.6	-0.4
Pulse rate, automated reading	0.2	0.8	0.9	-0.6	-1.0	-0.9	-0.9	-0.9
Chest pain or discomfort	0.2	0.3	1.0	1.0	0.5	0.4	0.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	-0.2	-0.4	-0.2	-0.3	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.9	0.9	0.3	0.4	0.4	0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.9	1.0	0.2	0.2	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.9	-0.3	0.5	0.4	0.4	1.0
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	-0.6	-0.4	-0.6	-0.5	-0.5
Friendships satisfaction	0.2	0.2	0.4	-0.3	0.5	0.4	0.4	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	-0.9	-0.4	-0.4	-0.3	-0.6
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.3	0.7	0.7	0.6	0.3
Leg fat percentage (left)	0.2	0.7	1.0	-0.1	-0.9	-1.0	-1.0	-0.9
Supplements: Calcium	0.2	0.2	0.7	0.8	-0.0	-0.1	-0.1	0.6
Arm predicted mass (left)	0.2	0.9	1.7	0.3	-1.1	-1.3	-1.1	-0.1
Bipolar Disorder (2018)	0.1	0.1	0.5	-0.7	-0.1	0.0	-0.1	-0.5
Depression (Nagel 2018)	0.1	0.2	0.8	0.2	0.2	0.1	-0.0	0.9
Schizophrenia (2018)	0.1	0.2	0.4	0.7	0.3	0.2	0.1	0.5
Fasting Glucose	0.1	0.1	0.2	-0.0	-0.3	-0.5	-0.4	-0.4
HDL Cholesterol	0.1	0.2	0.4	0.6	0.2	0.1	0.2	-0.6
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	-0.2	-0.4	-0.5	0.3
BMI	0.1	0.5	1.0	1.0	-0.7	-0.8	-0.7	-0.1
Lung FEV1/FVC ratio	0.1	0.4	1.1	-1.1	-0.2	-0.0	-0.1	-0.9
Tanning	0.1	1.1	3.3	1.8	-0.8	-0.8	-0.7	-0.7
Sensitivity / hurt feelings	0.1	0.2	0.3	0.4	-0.6	-0.4	-0.5	-0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.2	0.2	0.5	0.5	0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.0	-0.1	-0.1	-0.1	-0.6
Diabetes (mother)	0.1	0.1	0.2	0.0	-0.4	-0.5	-0.5	-0.2
Impedance of leg (right)	0.1	0.3	1.1	-1.0	0.2	0.3	0.1	-0.4
Leg fat-free mass (left)	0.1	0.4	1.1	0.9	-0.1	-0.4	-0.1	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.3	-0.2	-0.3	-0.4	0.3
Relative age voice broke	0.1	0.1	0.4	-0.3	0.1	-0.0	0.0	0.6
Age when periods started (menarche)	0.1	0.3	0.6	0.1	-0.8	-0.7	-0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	-0.6	0.3	0.4	0.4	-0.9
Body mass index (BMI)	0.1	0.3	1.1	1.0	-0.3	-0.5	-0.4	-0.2
Impedance of leg (left)	0.1	0.4	1.5	-1.2	0.2	0.4	0.2	-0.6
Leg predicted mass (left)	0.1	0.4	1.0	0.9	-0.2	-0.4	-0.2	1.0
Waist circumference	0.1	0.2	0.4	0.7	-0.4	-0.6	-0.5	-0.0
Allergy	0.1	0.2	0.6	-0.1	-0.5	-0.4	-0.4	-0.8
Pain all over the body in last month	0.1	0.1	0.3	0.5	-0.4	-0.3	-0.3	0.1
Illnesses of siblings	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.3	0.1
Weight	0.1	0.4	1.1	1.1	0.1	-0.1	0.1	0.9
Arm fat percentage (right)	0.1	0.4	1.3	1.1	0.4	0.3	0.3	0.5
Trunk fat-free mass	0.1	0.5	1.0	0.4	-0.8	-1.0	-0.8	0.4
Worrier / anxious feelings	0.1	0.3	0.4	0.0	-0.7	-0.6	-0.6	-0.4
Illnesses of mother	0.1	0.1	0.2	-0.5	-0.3	-0.4	-0.2	0.0
Arm fat mass (right)	0.1	0.4	1.5	1.2	0.1	-0.1	0.1	0.5
Trunk predicted mass	0.1	0.5	1.0	0.4	-0.9	-1.0	-0.8	0.4
Breastfed as a baby	0.1	0.1	0.2	0.4	-0.2	-0.3	-0.4	0.4
Tense / ‘highly strung’	0.1	0.2	0.3	0.4	-0.5	-0.4	-0.5	-0.5
Peak expiratory flow (PEF)	0.1	0.2	0.9	-0.9	0.2	0.1	0.1	-0.1
Pulse wave reflection index	0.1	0.1	0.4	0.3	0.1	-0.0	-0.1	0.6
Loud music exposure frequency	0.1	0.1	0.6	0.2	0.1	-0.1	-0.1	0.8
Gout (self-reported)	0.1	0.1	0.2	-0.2	0.3	0.4	0.3	-0.5
Body fat percentage	0.1	0.4	1.2	1.1	0.4	0.3	0.3	0.5
Arm fat-free mass (right)	0.1	0.6	1.0	0.6	-0.9	-1.0	-0.8	0.2
Worry too long after embarrassment	0.1	0.1	0.2	-0.4	0.4	0.5	0.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.5	0.7	-0.1	-0.2	-0.2	0.3
Number of children fathered	0.1	0.1	0.2	0.4	-0.1	0.0	0.0	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.0	-0.3	-0.3	-0.4	-0.1
Migraine (self-reported)	0.1	0.2	0.3	0.6	0.4	0.4	0.4	0.3
Medication: Allopurinol	0.1	0.1	0.2	0.1	0.4	0.4	0.2	-0.0
Medication: Omeprazole	0.1	0.1	0.6	0.8	-0.0	0.1	0.2	-0.0
Whole body fat mass	0.1	0.4	1.3	1.1	0.2	0.0	0.1	0.7
Leg fat mass (right)	0.1	0.3	0.6	0.5	-0.6	-0.7	-0.6	-0.2
Arm predicted mass (right)	0.1	0.6	1.1	0.6	-0.9	-1.1	-0.9	0.2
Overall health rating	0.1	0.2	0.4	0.6	-0.3	-0.4	-0.5	0.0
Age at last live birth	0.1	0.1	0.2	-0.4	-0.0	0.0	0.0	-0.5
Illnesses of father: Heart disease	0.1	0.1	0.2	0.3	0.3	0.4	0.2	0.5
Whole body fat-free mass	0.1	0.4	0.7	0.7	-0.6	-0.8	-0.6	0.6
Leg fat-free mass (right)	0.1	0.5	1.3	1.0	0.1	-0.2	0.1	1.1
Arm fat percentage (left)	0.1	0.3	1.3	1.1	0.3	0.2	0.2	0.4
Loneliness, isolation	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.2	-0.1
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.2	-0.4	-0.3	-0.4	-0.3
Whole body water mass	0.1	0.5	0.9	0.6	-0.7	-0.9	-0.7	0.5
Leg predicted mass (right)	0.1	0.4	1.2	0.9	0.0	-0.2	-0.0	1.1
Arm fat mass (left)	0.1	0.2	0.8	0.9	-0.3	-0.4	-0.3	0.1
Miserableness	0.1	0.1	0.4	-0.6	0.2	0.1	-0.1	0.3
Guilty feelings	0.1	0.1	0.3	-0.2	0.3	0.1	0.1	0.5
Hearing aid user	0.1	0.1	0.3	-0.6	-0.2	-0.1	-0.2	-0.5
Mother’s age at death	0.1	0.1	0.3	0.5	-0.3	-0.2	-0.2	-0.3
Financial situation satisfaction	0.1	0.2	0.3	-0.0	-0.5	-0.5	-0.5	-0.0
Commuting to job workplace: Public transport	0.1	0.2	0.2	-0.0	-0.4	-0.5	-0.5	-0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.6	0.2	0.3	0.2	-0.4
Medication: Lisinopril	0.1	0.1	0.6	0.7	0.3	0.2	0.2	0.2
Basal metabolic rate	0.1	0.4	0.6	0.8	-0.5	-0.7	-0.5	0.6
Arm fat-free mass (left)	0.1	0.7	1.4	0.4	-1.1	-1.2	-1.0	-0.0
Irritability	0.1	0.1	0.6	0.8	-0.2	-0.1	-0.2	0.2
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.2	-0.3
Myopia	0.1	0.1	0.3	0.5	0.2	0.3	0.2	0.0
Cholesterol lowering medication	0.1	0.2	0.4	-0.2	-0.4	-0.6	-0.6	0.2
Pain experienced in last month	0.1	0.1	0.3	-0.0	0.4	0.4	0.5	-0.3
Leg fat mass (left)	0.1	0.3	0.5	0.5	-0.6	-0.7	-0.6	-0.2
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.1	0.2	0.2	0.0	0.1
Worry (Nagel 2018)	0.0	0.1	0.2	0.5	-0.2	-0.2	-0.3	-0.0
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.4	-0.1	-0.0	0.0	0.4
Schizophrenia (2014)	0.0	0.0	0.1	0.3	0.2	0.2	0.1	0.1
Height	0.0	0.5	2.6	-0.3	0.2	-0.0	0.2	1.6
Neuroticism	0.0	0.1	0.1	0.4	-0.1	-0.2	-0.3	0.3
Medication for hormone replacement therapy	0.0	0.0	0.1	0.0	0.2	0.3	0.3	0.2
Vitamin and mineral supplements	0.0	0.0	0.2	0.1	-0.1	0.0	0.1	-0.4
Medication: Atenolol	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.1	-0.2
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.0	-0.3	-0.3	-0.4	-0.1
Nervous feelings	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.2
Neuroticism score	0.0	0.1	0.3	0.2	-0.1	-0.1	-0.2	0.5
Falls in the last year	0.0	0.1	0.1	0.1	0.3	0.2	0.2	0.3
Asthma	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	-0.2	-0.1	-0.0	-0.1	-0.1
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.1	0.2	0.3	0.2	0.3
Headache pain in last month	0.0	0.1	0.2	0.1	-0.2	-0.1	-0.2	0.4
Birth weight	0.0	0.1	0.2	0.5	0.1	-0.2	-0.1	0.3
Comparative body size at age 10	0.0	0.1	0.2	0.1	-0.5	-0.4	-0.2	-0.4
Number of full brothers	0.0	0.0	0.0	0.2	-0.1	-0.2	-0.2	0.2
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	-0.2	0.0	-0.1	-0.1	0.4
Eye problems/disorders: None of the above	0.0	0.0	0.0	-0.1	-0.1	-0.2	-0.1	0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.1	0.1	0.1	0.0	0.2
Supplements: Vitamin C	0.0	0.0	0.1	-0.2	0.1	0.0	-0.1	0.3
Knee pain experienced in last month	0.0	0.1	0.2	-0.5	-0.0	-0.2	-0.2	-0.0
Ever had bowel cancer screening	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.1	0.3
Asthma (self-reported)	0.0	0.0	0.0	-0.1	0.2	-0.0	-0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.1	0.1	0.2	0.1	0.1
Number of operations (self-reported)	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2	0.3
Age started oral contraceptive pill	0.0	0.0	0.0	-0.2	0.2	0.1	0.1	0.1

Hub : Genes

VTN

Models

Trait associations