Hub : Genes

WBSCR17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.3250	0.0537	5.2e-09	0.179	NA	0.163	NA	0.187	5.8e-14	NA	8.8e-13	NA	1.4e-14
2	GTEx	Esophagus Muscularis	0.2650	0.0640	1.2e-04	0.106	NA	0.168	NA	0.138	5.7e-07	NA	2.0e-10	NA	9.7e-09
3	GTEx	Heart Atrial Appendage	0.1950	0.0650	5.2e-03	0.006	NA	0.010	NA	0.033	1.6e-01	NA	1.1e-01	NA	1.3e-02
4	GTEx	Heart Left Ventricle	0.3344	0.0630	1.1e-06	0.220	NA	0.228	NA	0.257	6.4e-12	NA	2.3e-12	NA	6.0e-14
5	GTEx	Lung	0.1572	0.0523	1.7e-03	0.028	NA	0.074	NA	0.055	3.1e-03	NA	2.5e-06	NA	5.0e-05
6	GTEx	Testis	0.3170	0.0790	3.5e-04	0.262	NA	0.258	NA	0.248	5.0e-12	NA	8.0e-12	NA	2.2e-11
7	GTEx	Thyroid	0.3000	0.0540	1.6e-08	0.226	NA	0.200	NA	0.214	3.1e-17	NA	3.3e-15	NA	2.6e-16
8	TCGA	Breast Invasive Carcinoma	0.0370	0.0165	9.2e-03	0.021	0.014	0.010	NA	0.020	3.4e-05	5.4e-04	3.4e-03	NA	4.6e-05
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0868	0.0313	1.2e-03	0.002	0.034	0.017	NA	0.004	1.9e-01	8.6e-05	4.2e-03	NA	1.1e-01
10	TCGA	Lung Adenocarcinoma	0.0678	0.0254	1.9e-03	0.027	0.024	0.029	NA	0.024	3.9e-04	7.5e-04	2.4e-04	NA	7.7e-04
11	TCGA	Lung Squamous Cell Carcinoma	0.0767	0.0296	3.7e-03	0.005	0.041	0.022	NA	0.014	7.3e-02	1.8e-05	1.4e-03	NA	9.4e-03
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.1400	0.0490	1.7e-03	0.032	0.032	0.003	NA	0.007	3.1e-03	2.9e-03	1.8e-01	NA	1.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.4	0.6	3.8	0.2	-0.5	0.3	-0.5	-0.4	0.5	-0.4	2.0	0.2	0.1	-1.3	0.8
Bipolar Disorder or Schizophrenia	0.4	1.0	7.6	1.1	0.6	-0.1	0.0	0.5	-0.4	0.3	2.8	0.6	0.5	-1.5	0.1
Depressed Affect (Nagel 2018)	0.8	1.8	13.5	0.7	0.4	0.9	0.8	0.9	-1.1	0.7	1.4	3.7	0.0	1.0	-0.6
Depression (Nagel 2018)	0.4	0.6	1.7	-1.1	-1.0	-1.0	-1.0	-0.1	0.4	-1.0	-0.3	1.3	-0.7	0.2	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	5.2	0.6	0.2	0.1	0.6	0.6	-0.7	0.7	2.3	0.6	1.4	-1.9	-1.1
Neuroticism (Nagel 2018)	0.8	1.9	12.2	0.7	-0.7	0.5	0.9	1.0	-1.2	0.8	1.8	3.5	-0.5	1.4	-0.3
Schizophrenia (2018)	0.5	1.0	3.8	1.3	1.1	-0.3	0.5	1.1	-0.9	0.7	1.9	0.6	0.6	-0.9	-0.5
Schizophrenia vs Biploar Disorder	0.7	0.9	2.5	-1.4	-0.2	-0.1	-1.0	0.1	1.6	-1.5	0.3	0.1	-1.4	0.0	-0.8
Worry (Nagel 2018)	0.8	1.7	6.1	-1.3	-2.5	-1.1	-0.9	-0.2	0.7	-1.2	1.6	1.7	-1.8	-0.4	-0.4
Alzheimer’s Disease (in mother)	4.3	5.1	9.3	-2.5	-2.5	-1.6	-2.8	-2.2	2.8	-2.8	1.2	-0.4	-3.0	-2.5	-0.5
Alzheimer’s Disease (in father)	0.8	0.8	1.8	-1.0	-0.6	-0.8	-1.3	-1.0	1.2	-1.2	0.8	0.2	-1.1	0.2	0.3
Alzheimer’s Disease (including proxy)	4.1	6.0	11.1	-3.1	-2.8	-2.2	-3.3	-2.4	3.1	-3.3	0.9	-0.3	-2.9	-1.7	0.4
Crohns Disease (2017)	0.3	0.6	2.4	0.3	0.5	0.4	0.0	0.6	-0.3	0.2	-0.6	1.5	0.9	-0.6	1.3
Irritable Bowel Disease (IBD)	0.1	0.2	1.1	0.4	0.4	0.4	-0.0	-0.1	-0.3	0.3	-0.1	1.0	-0.1	-0.7	0.3
Ulcerative Colitis (UC)	0.2	0.5	1.2	1.1	0.9	0.6	0.6	-0.6	-0.8	0.9	0.5	0.8	-0.3	0.0	-0.3
Major Depression (MDD)	2.1	2.5	8.6	1.2	0.4	1.1	1.3	1.6	-1.2	1.0	2.5	2.9	1.9	0.1	1.3
Reaction Time	4.1	7.9	15.4	-3.4	-2.8	-1.8	-3.5	-3.3	3.9	-3.6	-0.9	-1.9	-3.4	-1.8	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.8	0.1	-0.5	-0.4	0.0	-0.2	-0.3	0.3	1.2	-0.3	0.5	-2.0	-1.3
Breast Cancer	0.2	0.5	3.4	0.1	-0.4	0.7	0.3	0.3	-0.5	0.4	-0.4	0.4	1.0	0.5	1.9
Ovarian Cancer	0.6	0.8	2.2	-0.7	-1.3	-0.3	-0.5	-0.2	0.7	-0.7	0.4	-1.3	0.4	-1.5	1.1
Prostate Cancer	1.4	1.9	5.4	1.1	1.1	2.0	1.4	1.6	-1.1	1.3	-1.9	0.3	0.8	2.3	-0.1
Age at First Birth	1.2	1.8	4.9	-1.8	-1.1	-0.5	-1.2	-1.2	1.7	-1.5	-0.9	-2.2	-0.3	-1.7	0.4
Bipolar Disorder (2011)	0.6	0.6	2.9	-0.2	-0.7	-0.5	-0.7	-0.1	0.6	-0.5	0.7	-1.7	-0.5	-0.4	1.0
Body Mass Index (BMI) (2010)	0.2	0.3	1.9	0.0	-0.6	-0.5	-0.1	-0.1	0.3	-0.2	0.3	1.4	-0.8	0.5	0.3
Coronary Artery Disease (CAD)	0.7	0.8	2.1	1.3	1.5	1.2	0.8	0.8	-1.0	0.7	-0.7	-0.1	0.7	0.7	-0.2
Crohns Disease (2012)	0.3	0.5	2.8	-0.4	-0.3	-0.1	-0.4	0.3	0.4	-0.4	0.2	0.4	0.5	-1.2	1.7
Mean Putamen Volume	0.6	0.7	3.5	0.6	0.4	1.9	0.6	0.0	-0.7	0.7	-0.7	0.2	0.3	-0.7	1.2
Fasting Glucose	0.3	0.3	1.1	0.4	0.5	-0.8	0.1	0.4	-0.6	0.3	-0.5	0.3	0.8	-1.0	0.2
HbA1C	0.4	0.4	2.4	0.7	0.5	-0.2	0.6	0.7	-0.5	0.4	0.1	0.1	0.5	-1.6	0.7
HDL Cholesterol	1.5	2.5	5.0	1.3	2.2	1.2	1.9	1.0	-1.5	1.7	0.7	0.5	1.9	2.2	1.6
LDL Cholesterol	0.4	0.7	2.7	0.4	0.8	-0.8	0.4	0.1	-0.7	0.5	-0.6	1.6	1.5	-0.5	-0.3
Lupus	0.2	0.3	1.3	-0.8	0.2	-0.2	-0.0	-0.2	0.1	-0.2	-1.2	-0.2	0.5	0.5	-1.0
Neuroticism (2016)	2.4	3.4	8.9	2.3	0.8	1.8	2.1	1.8	-2.3	2.4	1.1	3.0	0.8	1.4	0.8
Primary Biliary Cirrhosis	1.3	1.9	4.9	1.7	2.2	0.7	1.4	0.6	-1.6	1.5	2.0	0.7	1.4	-0.1	1.1
Rheumatoid Arthritis	0.5	0.7	3.1	0.6	0.8	1.1	0.6	0.2	-0.7	0.6	0.0	0.3	1.0	1.8	0.3
Schizophrenia (2014)	0.4	1.0	6.9	0.4	0.3	-0.4	-0.6	0.6	0.3	-0.3	2.6	-0.4	-0.6	-1.6	0.1
Triglycerides	0.3	0.4	2.0	0.1	0.3	-1.4	-0.5	-1.1	0.1	-0.3	-0.4	0.1	-0.6	-0.3	-1.0
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.6	1.6	1.7	0.8	0.8	1.0	-1.5	1.0	-0.8	0.8	-0.1	1.9	-0.8
Ulcerative Colitis	0.3	0.4	0.9	0.6	0.5	0.4	0.6	0.8	-0.8	0.7	0.5	0.4	-0.3	0.9	-0.6
Blood Eosinophil Count	0.1	0.8	3.3	1.2	1.2	1.8	0.5	-0.5	-0.9	0.6	0.5	0.1	0.3	-0.2	1.3
Blood Platelet Count	0.0	0.5	1.3	0.6	0.2	-0.2	0.3	-0.1	-1.1	0.6	-1.1	1.1	0.7	0.9	0.4
Blood Red Count	0.2	1.9	9.4	-0.9	-1.2	-0.6	-1.4	-1.8	1.1	-1.1	-3.1	-1.0	-0.8	-0.9	0.9
Blood White Count	0.3	1.9	4.0	-1.5	-1.4	-1.4	-1.8	-2.0	1.5	-1.8	-0.4	-0.6	-0.2	-0.6	1.8
Heel T-Score	0.5	4.3	9.5	2.2	3.1	-0.6	2.6	1.2	-2.9	2.8	-0.3	1.2	2.8	1.5	0.2
BMI	0.3	1.9	13.0	-0.0	0.4	-1.1	0.6	-0.2	-0.3	0.6	-3.6	-0.7	1.8	-1.2	-1.6
Height	0.2	4.2	16.2	0.2	-1.3	-0.6	-1.8	-2.8	1.3	-1.4	4.0	-1.8	-1.6	-1.8	3.0
Waist Hip Ratio (WHR)	0.5	2.4	4.5	1.8	2.1	1.4	1.4	1.6	-1.8	1.6	-0.2	0.8	2.0	2.1	0.2
Systolic Blood Pressure	0.2	0.9	4.1	0.1	-0.7	-1.0	0.3	0.8	-0.3	0.5	-2.0	-1.0	0.1	1.1	-1.2
Smoking Status	1.7	4.2	8.5	2.2	2.1	1.1	2.1	2.0	-2.1	2.2	0.3	2.7	2.9	1.5	2.0
Allergy or Eczema	0.4	1.0	2.4	0.3	0.6	1.1	1.2	0.3	-1.1	0.9	0.1	1.4	1.0	1.1	-1.5
Cardiovascular Disease	0.1	0.3	1.7	-0.2	-0.2	-1.1	-0.5	-0.2	-0.3	-0.0	-1.3	-0.3	0.2	-0.0	0.2
Hypothyroidism (self reported)	0.5	1.2	3.4	1.6	1.2	1.0	0.8	0.5	-1.5	1.3	-1.2	-0.1	0.2	1.8	0.4
Respiratory disease	0.4	0.8	3.0	1.0	0.2	1.7	0.3	0.7	-0.7	0.4	-0.2	1.5	0.3	1.3	-0.8
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.0	0.5	1.4	1.1	0.9	0.9	-0.8	0.8	0.7	0.7	1.4	0.7	0.5
Lung FEV1/FVC ratio	0.1	0.4	1.9	-0.1	-0.0	-0.0	-0.5	0.4	0.9	-0.6	0.4	-0.7	-0.9	0.5	1.4
Lung FVC	0.4	2.0	5.3	-1.8	-0.8	-1.2	-1.1	-1.8	1.6	-1.4	-0.1	-0.1	-2.3	-1.4	-1.2
Neuroticism	1.4	3.4	22.9	0.7	-0.1	1.1	1.0	1.2	-1.3	0.9	2.5	4.8	-0.1	2.1	-0.2
Chronotype (morning person)	1.6	3.8	8.6	2.9	2.6	1.8	2.5	1.9	-2.3	2.6	-0.4	-0.6	1.8	0.6	1.1
Hair Pigment	0.0	0.4	1.0	-0.6	-0.9	-0.9	-0.7	0.4	0.8	-0.8	0.3	0.0	0.3	-1.0	0.1
Tanning	0.1	0.8	4.4	-0.1	1.2	0.6	0.1	-0.7	0.3	0.0	-2.1	0.3	-0.7	-0.7	-1.1
Hand grip strength (left)	0.2	0.5	3.4	0.7	0.1	-0.5	-0.1	-1.0	0.2	-0.0	1.8	-0.4	-0.7	-0.7	-0.4
Number of treatments/medications taken	0.8	1.5	9.7	1.3	1.2	-0.1	0.8	0.8	-1.4	1.0	-0.1	0.9	0.4	3.1	0.4
Average weekly spirits intake	0.5	0.7	1.4	1.1	0.6	0.9	1.1	1.1	-1.0	1.2	-0.4	-0.3	0.5	-0.4	-0.2
Sensitivity / hurt feelings	2.2	3.8	8.5	1.5	0.6	2.5	1.7	1.5	-1.6	1.6	2.6	2.8	0.1	2.9	1.7
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.0	-1.0	0.1	0.0	-0.8	0.5	0.3	-0.8	0.8	1.4	-0.6	1.0	0.1
Hearing difficulty/problems: Yes	0.6	0.9	4.6	0.0	-0.4	2.2	0.3	-0.2	-0.6	0.4	-1.6	0.8	-0.7	1.0	-0.6
Relative age of first facial hair	0.4	0.7	1.8	-0.9	-0.7	-0.1	-0.9	-0.8	1.2	-1.1	-0.7	-0.8	-1.3	0.7	-0.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.3	-0.8	-0.9	-1.4	-1.0	-0.8	0.7	-0.9	-0.6	-0.1	-0.3	-1.5	-0.8
Ever used hormone-replacement therapy (HRT)	2.0	2.6	6.1	2.0	1.3	2.1	1.5	2.5	-1.8	1.8	0.1	-0.1	0.5	2.2	1.3
Ever had hysterectomy (womb removed)	0.3	0.4	1.2	-0.4	-0.6	-0.3	-0.6	-0.9	0.3	-0.3	-1.1	-0.3	-0.6	0.4	1.0
Systolic blood pressure, automated reading	0.4	1.1	4.9	-0.1	-0.8	-1.9	-0.0	-0.2	0.1	0.1	-2.2	-1.4	-0.3	0.9	-1.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	4.8	0.3	0.9	1.5	0.5	1.1	-0.4	0.5	1.2	0.6	-0.2	2.2	0.3
Angina	0.6	0.8	2.2	0.8	1.1	0.5	0.8	1.5	-0.9	0.9	-0.9	0.7	1.1	0.8	0.7
Medication for hormone replacement therapy	1.3	1.4	6.2	0.8	1.2	1.3	0.9	1.1	-0.9	1.0	-1.0	-0.4	-1.0	2.5	-1.2
Vitamin and mineral supplements	1.1	1.5	5.2	-1.5	-0.3	-0.7	-1.0	-1.1	1.3	-1.1	-1.8	-2.3	-0.8	-1.2	-0.1
Supplements: Zinc	0.9	1.0	4.7	0.4	1.2	-0.7	0.5	-0.7	-0.3	0.5	-2.1	0.0	-0.1	0.3	-2.2
Medication: Co-codamol	0.5	0.6	1.8	-0.5	-1.4	-0.8	-0.8	-0.3	0.5	-0.8	0.2	0.0	-0.7	1.0	0.9
Medication: Metformin	1.0	1.4	4.6	0.5	2.1	0.6	1.3	0.9	-0.8	0.9	1.0	1.2	1.5	1.8	-0.6
Diabetes (father)	0.3	0.4	2.9	-0.0	-0.5	0.3	-0.4	-0.3	0.4	-0.3	-0.4	-1.7	-0.1	0.1	0.9
Diabetes (mother)	0.3	0.4	1.4	-0.2	-0.6	-0.7	-0.7	-0.5	0.1	-0.4	0.9	0.8	0.1	-0.9	1.2
Severe depression (siblings)	0.5	0.6	1.9	0.4	-0.5	0.8	0.5	0.3	-0.9	0.6	-0.2	1.1	0.3	1.4	1.3
Pack years adult smoking proportion	0.2	0.3	1.8	0.1	0.8	-1.3	-0.5	-0.0	-0.2	-0.2	-0.6	0.6	-0.4	0.6	0.4
Impedance of leg (right)	0.1	0.6	2.8	0.1	-1.0	-0.3	-0.4	0.4	-0.2	-0.3	1.0	0.3	-0.5	0.9	1.7
Leg fat-free mass (left)	0.1	0.7	2.7	0.2	0.4	-0.7	-0.2	-1.6	0.3	0.1	-0.9	-0.9	0.3	-0.8	-1.5
Trunk fat percentage	0.2	0.7	2.8	0.6	0.2	-0.9	0.6	0.0	-0.8	0.8	-1.7	-0.9	1.6	0.1	-0.1
Hand grip strength (right)	0.1	0.4	1.9	0.6	-0.4	-1.0	-0.2	-0.6	0.2	-0.1	1.4	-0.1	-0.5	-0.3	-0.3
Townsend deprivation index at recruitment	0.2	0.3	1.2	0.2	0.1	-0.4	-0.5	-0.3	0.1	-0.1	-0.4	-1.0	-0.4	1.1	-0.0
Current tobacco smoking	0.2	0.4	1.5	-0.4	0.1	0.1	0.0	0.1	0.1	-0.2	-0.5	1.2	1.1	0.6	1.2
Average weekly fortified wine intake	0.8	0.9	1.7	1.2	1.0	-0.1	1.2	0.5	-1.2	1.3	-0.5	-0.5	1.3	-0.6	-1.1
Maternal smoking around birth	2.5	3.7	6.7	2.5	2.0	0.1	2.4	1.8	-2.6	2.5	1.7	1.7	1.2	2.1	-0.4
Fed-up feelings	1.6	2.9	10.6	1.1	1.6	1.5	1.6	2.2	-1.5	1.4	-0.2	3.3	0.7	2.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	-0.3	-0.1	-0.8	-0.2	0.3	-0.4	-0.1	-1.3	1.3	-0.5	0.8	-1.5
Relative age voice broke	2.6	3.9	6.7	-2.4	-2.1	-0.8	-2.3	-1.7	2.6	-2.4	-2.0	-2.1	-2.6	0.4	-0.2
Taking other prescription medications	0.3	0.5	1.4	0.0	0.1	-0.7	-0.2	0.5	-0.2	-0.2	1.2	1.2	0.7	1.0	1.0
Age when periods started (menarche)	0.6	1.6	3.8	1.1	1.4	1.5	1.0	0.4	-1.1	1.1	1.4	1.9	1.0	1.6	-0.7
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	4.0	0.4	-0.4	1.0	0.5	0.3	-0.5	0.6	-1.0	-0.4	0.7	1.9	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	2.4	0.2	1.6	-0.4	0.0	-0.0	-0.3	0.1	1.0	0.5	0.4	-0.3	0.6
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	3.2	0.6	-0.1	1.5	1.5	1.4	-1.2	1.3	-0.3	0.6	1.8	0.9	-1.4
Qualifications: CSEs or equivalent	0.4	0.6	2.5	-0.8	-0.8	-0.2	-0.5	-0.5	0.8	-0.6	-0.6	0.7	-0.7	1.6	0.1
Serious illness, injury or assault to yourself	0.6	0.8	2.0	-1.4	-0.3	-0.9	-0.8	-0.6	1.2	-1.2	0.8	0.9	-0.0	-0.8	0.7
High blood pressure	0.1	0.3	1.3	-0.2	-0.1	-0.9	-0.2	-0.2	-0.3	0.0	-0.3	-0.6	0.5	1.1	0.2
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.4	0.7	0.9	1.6	1.4	0.8	-1.2	1.2	0.3	2.1	1.3	0.1	-0.5
Multivitamins +/- minerals	2.0	2.6	13.2	1.4	1.0	1.2	0.9	1.2	-1.4	1.1	2.2	3.6	1.0	1.4	0.0
Stomach or abdominal pain in last month	1.1	1.3	3.0	1.1	0.8	0.5	1.3	1.2	-1.3	1.3	-0.3	1.7	1.3	1.6	-0.7
Supplements: Glucosamine	0.5	0.7	1.5	1.0	-0.3	0.3	1.1	1.1	-0.6	1.0	0.9	0.4	0.4	1.2	-1.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	4.0	-0.2	-0.8	0.2	-0.3	0.2	-0.1	0.0	0.8	1.6	1.0	-0.9	2.0
Medication: Atenolol	0.2	0.2	1.1	0.1	0.0	-0.5	0.4	0.1	-0.3	0.4	-1.1	0.1	0.8	-0.1	0.2
Medication: Levothyroxine sodium	0.4	0.6	4.7	0.6	0.6	0.3	-0.1	-0.5	-0.3	0.3	-0.9	0.2	-0.9	2.2	0.1
Sitting height	0.6	4.0	9.4	-1.5	-1.5	-1.9	-2.1	-3.1	2.4	-2.0	1.1	-2.1	-1.0	-2.9	0.4
Chronic bronchitis/emphysema (father)	3.4	4.0	9.7	1.7	2.4	0.9	1.7	1.9	-1.8	1.7	3.0	3.1	2.5	0.9	0.2
High blood pressure (mother)	0.8	1.1	3.8	0.5	0.8	1.8	0.5	1.4	-0.6	0.7	-1.4	0.0	0.0	0.7	2.0
Body mass index (BMI)	0.3	1.2	8.7	-0.2	0.5	-1.2	0.1	-0.5	-0.1	0.3	-3.0	-0.7	1.2	0.1	-1.2
Impedance of leg (left)	0.2	0.9	5.2	0.0	-1.1	0.1	-0.2	0.7	-0.1	-0.3	1.6	0.5	-0.1	0.9	2.3
Leg predicted mass (left)	0.1	0.6	2.4	0.3	0.5	-0.7	-0.1	-1.5	0.2	0.2	-0.9	-0.8	0.4	-0.8	-1.5
Trunk fat mass	0.2	0.7	2.3	0.5	0.3	-1.2	0.3	-0.6	-0.5	0.6	-1.5	-1.0	1.3	-0.2	-0.4
Waist circumference	0.3	1.1	3.9	0.8	1.2	-1.0	0.7	-0.1	-0.9	1.0	-2.0	-0.3	1.6	0.6	-0.9
Number of incorrect matches in round	1.2	2.0	3.8	1.6	1.9	1.8	1.5	1.9	-1.4	1.5	-0.1	0.4	1.1	0.8	1.7
Past tobacco smoking	1.2	2.2	4.8	-2.1	-2.2	-0.8	-1.9	-1.6	1.9	-2.0	0.6	-0.3	-1.3	-0.9	0.3
Alcohol usually taken with meals	4.7	7.6	14.4	3.6	2.5	2.5	3.8	1.1	-3.7	3.7	1.3	3.1	3.0	1.8	0.1
Nervous feelings	1.0	1.9	4.2	-1.7	-2.1	-1.1	-1.2	0.4	1.2	-1.4	1.4	1.3	-2.1	-0.6	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.8	-1.2	-1.3	-0.3	-1.2	-0.0	1.0	-1.3	0.4	0.2	-0.9	0.8	1.3
Hearing difficulty/problems with background noise	0.7	1.1	5.2	-0.1	-0.1	2.0	0.1	0.1	-0.3	0.2	0.3	2.3	-0.9	1.5	-0.7
Hair/balding pattern: Pattern 2	0.8	1.0	4.2	0.8	0.9	1.0	1.3	0.5	-1.2	1.1	-0.6	-0.1	2.0	0.3	0.4
Had menopause	0.2	0.2	1.0	-0.2	-0.3	0.5	0.1	0.0	-0.1	0.2	-0.1	0.1	-1.0	0.5	0.7
Had other major operations	0.6	0.7	1.3	0.6	0.6	-0.4	0.8	0.6	-0.9	0.8	-1.0	1.1	1.1	1.1	-0.6
Forced vital capacity (FVC)	1.1	4.1	7.2	-2.0	-2.3	-1.3	-2.2	-2.6	2.7	-2.4	1.6	-0.2	-2.7	-1.9	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.4	1.2	1.5	0.4	0.7	0.6	-1.1	0.9	1.5	0.7	0.9	0.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.7	0.2	-0.2	1.0	-0.1	-0.2	-0.4	0.0	1.6	1.6	0.1	0.1	0.7
Qualifications: None of the above	1.1	2.3	7.2	1.4	2.7	0.4	1.0	1.4	-1.2	1.2	-1.2	1.6	0.9	2.5	-0.9
Financial difficulties in last 2 years	0.4	0.5	2.2	-0.3	-0.3	-1.2	-0.3	0.6	0.3	-0.4	1.0	1.5	-0.5	-0.5	0.1
Mouth/teeth dental problems	0.7	1.1	6.4	0.3	-0.2	0.4	0.4	0.1	0.0	0.4	-0.7	-2.2	0.9	-0.4	2.5
Heart attack	0.5	0.6	1.7	-0.2	-0.0	-0.7	0.2	1.0	-0.3	0.2	0.9	1.0	1.3	-0.8	1.1
Allergy	0.9	2.1	8.1	-1.1	-1.2	-1.6	-1.1	-1.2	1.5	-1.3	-0.2	-2.8	-1.7	-1.1	1.1
Pain all over the body in last month	1.2	1.3	3.4	-1.0	-1.4	-0.1	-1.3	-0.3	1.1	-1.1	-1.0	-1.4	-1.8	-1.3	0.5
Diabetes (self-reported)	0.4	0.6	1.7	-0.1	1.1	0.0	0.7	-0.2	-0.5	0.5	0.2	0.7	1.3	1.3	-0.7
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.9	0.1	0.7	0.1	0.9	1.7	-0.6	0.6	0.1	0.8	0.8	-0.8	-2.0
Medication: Ramipril	0.9	1.2	3.9	-1.1	-0.9	-2.0	-1.4	-0.2	0.9	-1.1	-0.5	0.5	-0.7	1.2	-1.4
Medication: Simvastatin	0.4	0.6	3.2	-0.6	-0.6	-0.3	-0.6	-1.3	0.3	-0.5	-1.0	-0.0	0.4	-0.2	1.8
Fluid intelligence score	0.5	1.0	5.5	-0.4	-0.4	-0.9	-0.5	-0.4	0.2	-0.3	1.9	0.8	-0.0	-2.4	-0.4
Illnesses of siblings	1.2	1.7	5.1	-1.4	-2.3	-1.6	-1.5	-0.9	1.3	-1.4	-0.5	-0.9	-1.7	-0.1	-0.7
Neuroticism score	1.6	3.3	16.8	1.1	0.3	1.6	1.4	1.8	-1.4	1.1	2.5	4.1	0.0	2.2	0.4
Weight	0.2	1.0	3.1	-0.4	-0.1	-1.8	-0.7	-1.7	0.6	-0.3	-1.5	-1.1	0.6	-1.0	-0.6
Impedance of arm (right)	0.3	1.5	8.0	0.7	-1.1	0.4	-0.3	1.0	-0.6	0.0	2.3	0.5	-0.4	0.4	2.8
Arm fat percentage (right)	0.2	0.9	4.2	0.5	0.5	-1.0	0.5	0.4	-0.9	0.9	-2.0	-0.4	1.6	0.1	0.2
Trunk fat-free mass	0.2	1.0	5.0	-0.3	0.1	-1.2	-1.0	-2.2	1.0	-0.6	-0.3	-0.8	-0.2	-1.2	-0.9
Hip circumference	0.2	1.1	4.1	-0.6	-0.4	-2.0	-0.8	-1.1	0.7	-0.5	-1.0	-0.8	0.2	-2.0	-0.1
Time employed in main current job	0.3	0.3	0.7	0.4	0.4	0.9	0.8	0.1	-0.4	0.6	0.3	-0.8	0.2	0.6	-0.8
Alcohol intake versus 10 years previously	1.4	2.0	9.5	-1.6	-0.9	-3.1	-1.8	-1.4	1.4	-1.6	1.3	-0.3	-0.2	-0.5	-0.5
Father’s age at death	0.7	0.9	4.4	0.7	0.3	0.7	0.2	1.1	-0.2	0.3	2.1	0.5	-0.0	-1.9	0.6
Worrier / anxious feelings	0.6	1.1	2.1	1.1	-0.9	0.7	1.1	1.2	-1.2	0.9	0.6	1.3	-1.1	1.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.4	-0.9	-0.2	-0.6	-0.8	-0.2	-0.0	-0.5	-0.9	1.0	-1.0	1.2	-1.0
Falls in the last year	0.1	0.1	0.6	-0.2	-0.1	0.5	-0.1	-0.3	0.2	-0.3	-0.1	0.8	-0.1	0.1	0.7
Hair/balding pattern: Pattern 3	1.3	1.9	4.7	-1.1	-1.3	-1.7	-1.5	-0.4	1.6	-1.5	0.3	-1.2	-2.2	-2.0	0.0
Number of live births	0.9	1.2	3.0	1.7	0.2	0.8	1.4	1.3	-1.2	1.3	-1.2	-0.9	-0.4	1.1	-0.5
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	6.2	-1.8	-2.1	-1.1	-2.0	-1.8	2.4	-2.1	1.5	-0.1	-2.5	-1.4	-0.2
Pulse rate	1.3	2.3	4.0	-1.4	-1.4	-1.4	-2.0	-1.1	1.6	-1.7	-1.4	-1.9	-1.9	-1.0	0.7
Happiness	0.6	0.7	4.0	-0.3	-0.5	0.5	-0.5	-0.3	0.2	-0.3	0.9	1.5	-0.6	-2.0	0.2
Noisy workplace	0.5	0.7	4.3	-0.4	0.5	-0.4	-0.3	-0.3	0.3	-0.3	-1.0	0.0	-1.2	0.5	-2.1
Qualifications: A levels/AS levels or equivalent	1.4	3.2	5.7	-1.9	-2.4	-1.6	-1.8	-1.5	1.8	-1.9	1.2	-1.1	-1.6	-2.4	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.2	0.0	-0.2	0.0	0.5	1.1	-0.4	0.4	0.6	0.6	0.7	-0.1	0.4
Mouth/teeth dental problems: Dentures	1.1	1.9	8.4	1.3	1.6	0.9	0.7	1.6	-1.2	0.9	0.6	2.9	0.2	1.4	-0.9
Asthma	0.5	0.9	5.5	1.1	0.3	1.6	-0.0	0.5	-0.6	0.3	-0.9	0.5	-0.4	2.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.9	-0.2	1.2	0.4	0.1	1.2	-0.3	-0.0	-0.9	1.4	-0.3	0.8	-0.1
Medication: Cholesterol lowering	0.1	0.1	0.4	0.3	0.3	-0.5	-0.0	-0.4	-0.3	0.2	-0.7	-0.1	0.3	0.5	-0.4
Depression (self-reported)	2.3	2.8	6.0	1.8	1.7	2.0	1.4	1.3	-1.9	1.6	2.5	1.6	1.2	1.8	0.6
Medication: Lansoprazole	0.3	0.4	3.3	-0.5	0.4	-0.4	-0.2	-0.6	0.5	-0.3	0.0	1.8	0.1	0.0	-0.1
Prospective memory result	0.3	0.4	2.7	0.1	0.1	-0.3	-0.2	-1.1	-0.2	0.0	0.5	-0.4	0.4	1.6	0.3
Lung cancer (father)	0.6	0.7	2.4	0.4	0.8	0.8	0.8	1.1	-0.6	0.7	0.1	1.6	0.7	0.4	1.0
Illnesses of mother	0.6	0.8	4.3	-0.8	-0.8	-2.1	-0.2	-0.3	0.5	-0.6	-0.4	-0.6	0.7	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	8.9	-2.2	-2.7	-1.7	-2.5	-2.2	2.8	-2.6	1.9	-1.0	-3.0	-2.0	0.4
Pulse wave Arterial Stiffness index	0.7	0.8	1.6	1.1	1.0	0.4	1.0	0.3	-1.3	1.2	-0.9	0.3	0.7	1.1	-0.0
Impedance of arm (left)	0.2	0.9	4.0	-0.1	-1.5	-0.2	-0.7	0.7	0.0	-0.5	1.6	-0.7	-0.8	-0.3	2.0
Arm fat mass (right)	0.2	0.7	3.4	0.4	0.5	-1.0	0.3	-0.3	-0.5	0.6	-1.9	-0.5	1.4	-0.3	-0.2
Trunk predicted mass	0.2	1.1	5.3	-0.4	0.1	-1.2	-1.1	-2.3	1.1	-0.7	-0.4	-0.9	-0.3	-1.3	-0.8
Standing height	0.2	2.4	7.0	-0.2	-1.2	-1.2	-1.6	-2.5	1.2	-1.2	2.6	-1.1	-1.1	-1.8	1.3
Length of working week for main job	1.1	1.2	3.4	1.0	0.9	1.0	1.2	1.2	-1.2	1.2	0.5	0.4	1.3	-0.4	1.8
Exposure to tobacco smoke at home	0.5	0.5	2.1	-0.5	-0.3	-1.4	-0.2	-1.4	-0.1	-0.2	-0.8	-0.5	-0.0	-0.4	-1.1
Breastfed as a baby	0.5	0.7	2.0	-0.5	-0.9	-0.2	-0.8	0.6	1.0	-0.7	0.4	0.4	-1.3	-1.4	0.5
Tense / ‘highly strung’	0.3	0.5	1.4	0.5	-0.2	0.6	0.4	0.9	-0.5	0.2	1.1	0.6	-0.8	1.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	5.9	1.2	0.1	0.4	0.9	1.2	-1.3	1.0	2.0	2.4	1.6	0.7	1.7
Hair/balding pattern: Pattern 4	0.6	1.4	2.3	1.2	0.9	1.5	0.9	1.0	-0.8	1.0	1.4	1.5	1.2	0.5	1.5
Birth weight of first child	0.4	0.7	3.9	-0.9	-0.1	0.1	-0.2	0.4	0.9	-0.5	-0.8	-0.4	-0.7	-2.0	-1.2
Peak expiratory flow (PEF)	0.5	1.1	3.3	-0.5	-1.3	-0.9	-1.3	-0.6	1.3	-1.1	1.4	-0.2	-1.8	-0.6	0.3
Pulse wave reflection index	0.4	0.5	1.3	0.5	1.0	1.1	0.5	0.3	-0.7	0.7	-0.6	0.5	0.9	-0.6	0.5
Ever highly irritable/argumentative for 2 days	3.0	3.6	14.4	1.7	1.9	1.6	1.6	1.7	-1.6	1.5	2.3	3.8	0.5	1.5	0.9
Loud music exposure frequency	0.2	0.2	1.1	0.3	0.3	0.6	0.2	-0.0	-0.2	0.1	0.4	1.0	-0.5	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.1	-0.9	-1.6	1.3	-0.3	-0.1	0.8	-0.6	-0.1	-0.7	-1.1	-1.7	-1.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	4.2	0.2	0.7	-0.3	0.5	0.9	-0.9	0.5	0.2	1.5	0.1	0.1	-2.0
Blood clot in the leg (DVT)	0.4	0.6	1.7	-0.4	-0.6	0.3	-1.0	-0.5	0.7	-0.7	-1.1	-0.2	-0.9	-1.3	0.0
Medication: Paracetamol	0.7	1.2	3.8	1.3	1.1	0.1	1.1	1.1	-1.3	0.9	-0.4	2.0	0.1	1.3	-0.6
Headache pain in last month	1.5	2.6	11.2	1.2	1.3	1.3	1.1	1.0	-1.4	1.1	-1.3	2.6	0.5	3.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.3	-1.4	-1.2	0.3	-0.9	-0.0	1.5	-1.4	0.1	-1.0	-1.2	-1.4	0.4
Glaucoma (self-reported)	0.6	0.7	4.0	0.2	-0.2	-0.5	0.7	0.3	-0.6	0.5	-2.0	-0.8	-0.0	0.7	-1.5
Gout (self-reported)	1.1	1.5	4.5	-1.3	-1.4	-2.1	-1.7	-0.2	1.4	-1.6	1.2	-0.2	-1.0	-0.4	0.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	7.2	2.1	1.8	1.5	1.2	1.1	-1.9	1.8	-0.2	0.7	1.0	2.7	0.4
Medication: Amlodipine	4.4	6.1	12.2	2.8	2.5	2.0	2.7	2.8	-3.2	3.0	-0.3	2.1	2.2	3.5	-0.1
Medication: Ventolin 100micrograms inhaler	2.6	3.3	6.8	2.6	2.0	1.0	2.0	1.5	-2.4	2.2	1.1	1.9	1.6	2.1	0.1
Birth weight	0.2	0.5	3.2	-0.4	-0.8	-0.6	-0.3	-0.0	0.4	-0.4	-0.6	-0.4	-0.0	-1.8	-0.9
Chronic bronchitis/emphysema (mother)	3.3	3.9	7.5	2.0	2.0	2.0	1.8	1.5	-2.1	2.0	2.7	2.7	2.3	0.5	0.9
High blood pressure (siblings)	0.8	1.2	5.5	0.8	0.9	1.1	1.0	0.5	-0.6	0.8	1.0	1.2	1.0	-0.4	2.4
Forced vital capacity (FVC), Best measure	1.8	6.5	11.1	-2.6	-2.9	-2.1	-2.8	-3.0	3.2	-3.0	2.1	-1.1	-3.3	-2.3	-0.4
Body fat percentage	0.2	0.9	4.6	0.5	0.2	-1.2	0.5	0.0	-0.8	0.7	-2.1	-0.8	1.6	0.2	-0.1
Leg fat percentage (right)	0.3	1.1	8.0	-0.1	-0.1	-1.6	-0.1	-0.5	-0.3	0.2	-2.8	-0.8	1.4	0.3	-0.1
Arm fat-free mass (right)	0.2	1.0	3.6	0.1	0.7	-0.8	-0.1	-1.9	0.2	0.1	-1.3	-0.8	0.4	-0.7	-1.9
Exposure to tobacco smoke outside home	1.2	1.5	7.8	0.1	-0.3	-1.0	-0.6	-1.4	-0.2	-0.3	-2.8	-1.8	-0.7	1.4	1.1
Comparative body size at age 10	0.5	1.5	5.5	-1.6	-1.0	-2.3	-1.3	-1.4	1.2	-1.2	-0.1	-0.7	0.3	-1.3	0.3
Number of full brothers	0.5	0.6	1.6	0.9	1.1	0.1	0.4	-0.1	-0.6	0.5	-0.2	-0.8	1.1	-1.2	1.1
Worry too long after embarrassment	1.1	1.8	4.8	1.1	0.4	1.5	1.3	1.2	-1.4	1.2	1.5	2.2	-0.5	2.0	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	6.8	1.4	0.9	1.5	1.5	1.1	-1.6	1.4	1.2	2.6	0.7	1.5	0.0
Wheeze or whistling in the chest in last year	0.6	1.1	6.0	0.7	1.0	0.9	0.5	1.2	-0.7	0.4	-0.2	2.5	-0.1	0.6	-1.7
Number of children fathered	0.4	0.4	1.8	0.2	-0.3	-0.8	0.2	0.4	-0.0	0.3	-1.2	-1.3	0.4	-0.6	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.6	0.4	0.2	0.3	0.1	1.0	-0.4	0.4	1.3	0.7	0.5	0.3	0.0
Age at first live birth	0.7	1.2	3.6	-0.8	-1.1	-0.3	-1.0	-1.1	1.0	-0.9	0.2	-0.5	-1.4	-1.4	-1.9
Pulse wave peak to peak time	0.7	0.8	1.7	-1.0	-1.1	-0.4	-0.9	-0.2	1.1	-1.1	1.2	-0.2	-0.4	-1.3	0.3
Health satisfaction	0.4	0.5	2.6	0.3	0.2	-0.4	-0.2	-1.5	-0.4	0.1	-0.1	1.6	-0.1	0.7	-0.0
Shortness of breath walking on level ground	0.5	0.6	1.5	-0.1	0.8	-1.0	0.3	0.6	-0.4	0.2	-0.3	0.9	1.0	-1.0	-1.2
Qualifications: College or University degree	2.7	8.6	32.8	-2.7	-3.4	-3.1	-2.4	-2.3	2.9	-2.7	0.9	-3.4	-1.1	-5.7	-1.3
Eye problems/disorders: None of the above	1.0	1.2	2.9	-1.5	-1.0	-1.1	-1.7	-0.8	1.6	-1.7	0.7	0.1	-0.6	-0.3	0.0
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.9	-1.0	-1.3	-0.5	-0.8	-0.0	1.2	-1.0	0.0	-1.3	-1.4	-0.2	-0.4
Emphysema/chronic bronchitis	1.4	1.5	3.0	-1.3	-0.9	-1.4	-1.4	-1.5	1.5	-1.5	-0.7	0.6	-0.0	-1.7	-1.3
Medication for pain relief, constipation, heartburn	0.4	0.6	2.6	-0.5	-0.7	-0.1	-0.2	-0.7	0.5	-0.1	-0.1	-1.1	0.3	-1.6	-1.4
Neck or shoulder pain in last month	1.6	2.3	10.5	1.0	1.5	1.3	0.6	0.7	-1.0	0.9	0.1	3.2	0.5	2.3	1.9
Medication: Blood pressure	1.6	2.9	5.5	1.9	1.9	-0.1	1.7	1.0	-2.4	2.1	-0.4	1.4	1.9	2.3	-1.6
Angina (self-reported)	0.5	0.7	1.8	0.6	1.0	0.8	0.7	1.4	-0.8	0.8	-0.6	0.9	0.9	0.8	0.5
Migraine (self-reported)	2.4	3.0	6.1	-2.0	-1.6	-1.8	-2.4	-1.1	2.2	-2.5	0.5	1.0	-2.3	-1.0	-0.4
Medication: Ibuprofen	0.4	0.5	2.2	-0.1	1.2	0.4	0.0	1.1	-0.1	-0.1	-0.7	1.5	-0.4	0.4	0.3
Medication: Allopurinol	1.2	1.5	3.6	-1.8	-0.7	-1.9	-1.6	-0.3	1.7	-1.7	0.7	-0.5	-1.2	-0.5	-0.5
Medication: Omeprazole	1.7	2.1	7.2	-1.3	-1.9	-1.4	-1.2	-1.3	0.8	-1.2	-1.2	-1.8	-0.8	-0.4	2.7
Medication: Seretide 50 evohaler	1.9	2.1	4.0	1.6	1.2	0.3	1.8	1.9	-1.6	1.7	-0.9	2.0	1.8	-0.3	-1.2
Mean time to correctly identify matches	5.0	9.6	16.3	-3.6	-2.8	-2.2	-3.9	-3.7	4.0	-3.8	-1.8	-2.2	-3.8	-2.6	0.9
Heart disease (mother)	0.9	1.1	2.1	1.0	1.4	0.9	1.4	0.7	-1.4	1.5	-0.5	0.3	0.8	0.1	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	1.2	-0.2	0.5	0.4	-0.2	0.5	0.1	-0.0	1.1	0.9	0.3	0.1	0.1
Whole body fat mass	0.2	0.8	4.0	0.4	0.2	-1.1	0.3	-0.7	-0.5	0.6	-2.0	-1.0	1.4	-0.0	-0.5
Leg fat mass (right)	0.2	0.9	5.1	0.3	0.4	-1.1	0.2	-0.8	-0.4	0.5	-2.3	-0.6	1.3	0.3	-0.7
Arm predicted mass (right)	0.2	0.9	3.0	0.1	0.6	-0.7	0.1	-1.7	0.2	0.2	-1.4	-0.9	0.6	-0.6	-1.7
Pulse rate, automated reading	0.1	0.5	1.7	-0.2	-0.2	0.2	-0.6	-1.3	0.6	-0.6	-1.0	-1.0	-0.2	0.5	0.8
Alcohol intake frequency.	0.2	0.5	1.9	-0.3	-0.6	-0.2	-0.5	-0.0	0.4	-0.7	0.1	-1.3	-1.4	1.2	0.6
Comparative height size at age 10	0.2	1.3	5.1	0.1	-1.2	-1.1	-1.0	-1.5	0.7	-0.5	0.2	-2.3	-0.9	-0.6	1.4
Number of full sisters	0.8	1.0	2.9	-0.8	-1.1	-0.7	-0.8	-0.6	0.7	-0.8	-1.7	-1.1	-0.8	0.8	-1.4
Suffer from ‘nerves’	1.3	2.1	6.5	-1.8	-2.5	-1.4	-1.5	-0.6	1.1	-1.5	0.4	1.9	-1.7	-0.3	0.5
Overall health rating	0.4	0.9	1.8	-1.2	-0.1	0.1	-1.2	-1.3	0.9	-1.3	0.1	0.7	-0.8	1.3	-0.7
Chest pain or discomfort	0.7	1.0	3.1	1.3	0.6	1.8	1.1	1.1	-1.2	1.1	-0.6	0.9	0.8	0.9	-0.1
Had major operations	0.3	0.4	1.1	-0.2	0.5	-0.6	0.1	0.4	-0.3	0.1	1.0	1.1	0.6	-0.9	-0.5
Age at last live birth	0.9	1.3	8.8	-0.7	-0.1	0.3	-0.4	-0.6	0.7	-0.6	-1.3	-0.5	-1.2	-1.0	-3.0
Family relationship satisfaction	0.3	0.3	1.6	0.4	-0.6	-0.0	0.2	0.2	-0.4	0.3	0.6	1.3	-0.3	-0.9	-0.6
Leg pain on walking	0.6	0.8	3.2	0.5	0.6	1.4	0.6	0.3	-0.7	0.6	0.4	1.8	0.6	1.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.9	0.3	0.6	0.3	0.2	0.1	-0.5	0.4	-0.6	0.4	1.0	0.5	0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.0	-1.1	-1.0	-1.6	0.1	-1.4	0.5	-0.3	-2.0	-0.3	0.3	-1.3	-1.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.8	0.8	-0.3	1.7	0.6	-1.1	-0.7	0.7	-0.2	-1.2	-0.2	0.6	-0.3
Medication: Aspirin	0.4	0.5	2.4	-0.8	-0.4	-0.2	-0.9	0.5	0.6	-0.8	0.6	-0.2	-0.4	-0.6	1.5
Supplements: Vitamin C	0.6	0.7	1.5	1.1	-0.1	-0.7	0.9	0.3	-1.2	1.0	1.2	0.4	0.4	1.0	-0.5
Knee pain experienced in last month	0.9	1.4	3.5	1.1	1.6	-0.9	0.8	1.7	-1.4	1.1	-0.5	1.1	0.5	1.9	-0.4
Hypertension (Self-reported)	0.1	0.3	1.1	-0.4	-0.3	-1.0	-0.5	-0.6	-0.0	-0.3	-0.1	-0.9	0.2	1.1	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	-0.9	-0.1	0.5	-0.2	0.2	0.7	-0.5	-1.1	-0.4	0.3	-1.0	-0.3
Illnesses of father: Heart disease	1.6	2.2	5.4	1.8	1.3	1.5	2.0	2.3	-1.8	2.0	-0.5	-0.7	0.8	0.9	0.0
Illnesses of siblings: Diabetes	0.3	0.4	1.7	0.9	0.8	-0.1	0.3	-0.2	-0.8	0.5	-0.5	-0.5	0.1	1.3	-0.7
Smoking status: Previous	2.0	3.0	6.8	2.4	2.6	1.1	2.2	1.8	-2.1	2.3	0.1	0.9	1.0	1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	5.2	-1.6	-1.9	-2.1	-2.3	-2.2	2.2	-2.3	1.8	-1.6	-1.4	-1.9	-0.1
Whole body fat-free mass	0.1	0.7	3.7	0.0	0.4	-0.8	-0.5	-1.9	0.6	-0.2	-0.7	-0.8	0.1	-0.9	-1.2
Leg fat-free mass (right)	0.1	0.5	2.2	0.2	0.4	-0.5	-0.2	-1.5	0.4	0.1	-0.5	-0.8	0.3	-0.8	-1.2
Arm fat percentage (left)	0.2	0.9	5.6	-0.0	0.1	-1.4	0.1	0.0	-0.4	0.4	-2.4	-1.1	1.2	-0.2	-0.3
Average weekly red wine intake	0.5	0.8	2.8	-0.5	-1.3	0.9	-0.4	-1.7	0.4	-0.4	-0.4	-1.3	-0.2	-0.1	-1.2
Handedness (chirality/laterality): Left-handed	0.7	0.9	6.7	0.7	0.6	0.7	-0.0	0.7	-0.2	0.2	1.0	-0.5	-0.3	-0.5	2.6
Mood swings	1.6	2.9	8.2	1.8	1.1	1.8	1.5	1.5	-1.6	1.3	2.4	2.9	1.0	1.5	1.3
Loneliness, isolation	2.5	3.4	14.7	1.3	1.8	1.8	1.3	1.2	-1.8	1.5	1.6	3.8	1.0	2.4	-0.2
Long-standing illness, disability or infirmity	0.3	0.5	1.8	0.3	-0.2	-0.2	0.2	-0.1	-0.7	0.3	0.8	1.4	1.0	1.1	0.6
Ever had bowel cancer screening	1.7	2.0	4.7	1.9	1.1	2.2	1.7	1.2	-1.6	1.8	-0.3	0.0	0.8	2.0	0.5
Diabetes diagnosed by doctor	0.4	0.7	2.2	0.1	1.4	0.6	0.9	0.3	-0.6	0.7	0.3	0.4	1.4	1.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.8	0.7	-0.2	0.3	-0.0	-0.6	-0.6	0.4	1.7	1.3	-0.8	1.4	-0.1
Friendships satisfaction	0.8	1.0	6.0	0.3	-0.4	0.4	0.2	-0.1	-0.5	0.4	0.8	2.4	-0.9	-2.0	-0.1
Qualifications: nursing, teaching	0.5	0.8	3.3	-0.0	0.0	0.1	0.2	-0.0	-0.0	0.1	1.8	-1.2	-0.2	-1.6	-1.4
Commuting to job workplace: Walk	0.5	0.5	1.5	0.7	0.6	1.2	0.6	0.9	-0.2	0.3	0.8	0.2	0.2	0.8	0.9
Eye problems/disorders: Cataract	0.4	0.4	1.5	0.0	-0.0	0.0	0.1	-0.9	-0.1	0.3	-1.0	-0.6	0.2	-1.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	4.4	-0.9	-0.1	-0.9	-0.2	-0.7	0.3	-0.4	0.3	0.7	-0.1	-0.4	-2.1
Medication for cholesterol	0.7	1.1	2.6	1.1	0.4	1.6	1.1	1.3	-0.6	1.0	0.6	1.4	0.7	-1.4	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.8	3.5	-1.4	-1.9	-1.8	-1.5	-1.8	1.3	-1.4	0.1	-0.4	-0.5	-1.3	1.5
Back pain experienced in last month	1.4	2.1	4.7	1.2	1.6	1.2	1.3	1.0	-1.5	1.3	-1.2	1.5	1.3	2.2	1.7
Mineral and other dietary supplements	0.3	0.4	2.7	-0.3	0.3	0.9	0.7	0.5	-0.2	0.3	-0.5	-0.5	0.5	-1.6	0.3
Breast cancer (self-reported)	0.4	0.5	3.8	-0.5	-0.5	0.7	-0.3	-0.2	0.3	-0.4	0.8	0.1	-0.3	-2.0	0.3
Asthma (self-reported)	0.4	0.9	5.2	1.0	0.2	1.5	-0.1	0.6	-0.5	0.3	-1.1	0.5	-0.3	2.3	-0.2
Osteoporosis (self-reported)	0.4	0.5	2.3	-0.0	-1.0	-0.1	0.1	-0.8	-0.2	0.2	-1.5	-1.0	0.2	0.3	1.1
Osteoarthritis (self-reported)	0.2	0.3	1.3	-0.1	-0.0	-0.0	0.5	1.1	0.1	0.1	-0.1	0.7	0.8	0.0	0.9
Medication: Aspirin	0.4	0.5	2.6	-0.3	-0.1	0.3	-0.4	1.0	0.1	-0.4	1.2	0.5	-0.1	-0.4	1.6
Medication: Gliclazide	0.5	0.5	2.4	-0.3	1.0	0.7	0.1	1.0	0.2	-0.0	1.5	1.0	-0.1	-0.1	-0.5
Illnesses of father: None of the above (group 1)	1.3	1.7	4.2	-1.5	-0.6	-1.9	-1.3	-2.0	1.4	-1.4	-1.3	-0.5	-0.4	-0.7	-1.1
Smoking status: Current	0.3	0.4	1.5	-0.0	0.3	0.3	0.2	0.0	-0.2	0.1	-0.6	1.1	1.2	0.7	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	9.0	-1.2	-1.9	-1.0	-1.6	-1.2	1.8	-1.6	1.3	-1.0	-3.0	-1.6	-0.7
Whole body water mass	0.1	0.7	3.8	0.0	0.4	-0.9	-0.5	-1.9	0.6	-0.2	-0.5	-0.9	0.1	-0.9	-1.2
Leg predicted mass (right)	0.1	0.5	2.0	0.2	0.5	-0.5	-0.2	-1.4	0.3	0.1	-0.4	-0.8	0.4	-0.8	-1.1
Arm fat mass (left)	0.2	0.8	4.3	0.1	0.4	-1.3	0.0	-0.6	-0.2	0.3	-2.1	-0.9	1.2	-0.5	-0.3
Number of self-reported non-cancer illnesses	0.5	0.9	4.4	0.8	0.7	0.4	0.4	0.1	-1.2	0.7	0.7	0.5	1.6	2.1	0.5
Average weekly champagne plus white wine intake	1.8	2.5	7.1	2.2	1.4	2.7	2.0	1.6	-1.6	2.0	-0.9	0.2	0.9	0.1	-0.8
Miserableness	0.3	0.6	2.2	-0.6	-0.5	-0.2	-0.5	0.8	0.2	-0.6	0.1	0.9	-1.5	-0.1	-1.4
Guilty feelings	2.7	4.1	12.4	1.8	0.9	3.5	1.8	2.5	-1.6	1.6	0.7	2.4	-0.3	3.3	-0.3
Wears glasses or contact lenses	2.5	2.9	6.8	1.9	1.7	2.0	1.7	2.6	-2.2	2.0	0.6	1.0	1.6	0.7	1.1
Ever taken oral contraceptive pill	0.9	0.9	3.6	1.0	0.4	0.3	1.2	0.5	-0.8	1.1	1.2	1.9	0.6	0.8	-0.6
Hearing aid user	1.4	1.5	5.3	-1.1	-1.1	-0.8	-1.6	-1.0	0.8	-1.0	-0.4	0.3	-2.3	1.4	-1.6
Mother’s age at death	0.4	0.6	3.5	-0.4	-0.6	0.2	-0.5	0.1	0.2	-0.3	-1.9	-0.1	-0.5	1.3	0.3
Financial situation satisfaction	0.5	0.6	1.8	0.6	-0.8	0.6	0.4	0.3	-0.7	0.6	-0.5	1.4	-0.4	0.9	1.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.8	1.0	1.1	-0.2	0.8	-0.2	-0.8	0.7	-0.7	-0.2	-0.5	0.4	-2.0
Commuting to job workplace: Public transport	1.3	1.6	4.3	1.5	1.6	1.6	0.8	0.6	-1.1	1.0	2.1	1.8	0.6	0.1	0.8
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	1.4	0.4	0.9	1.5	1.1	-1.5	1.5	-1.5	-0.4	0.8	0.5	-0.7
Medication: Blood pressure	0.2	0.5	3.3	-0.2	-0.0	-1.8	-0.2	-0.0	-0.1	-0.1	0.1	-1.0	0.3	1.0	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	3.0	0.7	0.3	0.8	0.4	0.7	-0.4	0.3	0.7	-0.0	0.1	0.4	1.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	0.5	-0.1	-0.4	-0.3	-0.5	-0.1	-0.1	0.8	0.4	0.3	0.8	0.1
High cholesterol (Self-reported)	0.3	0.5	1.6	0.0	-0.2	-0.9	0.0	-1.1	-0.3	0.1	-1.3	-1.0	0.8	0.9	0.2
Medication: Bendroflumethiazide	0.3	0.5	2.0	-0.3	-0.4	-1.4	-0.2	-0.9	-0.3	0.0	-0.5	-0.7	0.7	1.0	0.0
Medication: Paracetamol	1.1	1.6	6.9	1.4	1.5	-0.1	1.3	1.2	-1.5	1.2	0.1	2.6	0.2	1.1	-0.8
Medication: Lisinopril	0.7	0.9	3.1	0.4	1.1	-0.6	0.6	0.5	-0.9	0.8	1.8	0.6	1.1	1.0	1.0
Medication: Atorvastatin	0.4	0.5	2.1	0.4	0.4	-0.3	0.8	0.6	-0.5	0.6	-0.9	-0.7	1.5	0.8	0.3
Illnesses of father: High blood pressure	1.7	2.1	8.2	1.0	-0.5	2.2	1.3	1.1	-1.4	1.4	1.3	0.6	1.4	0.6	2.9
Alcohol drinker status: Never	0.4	0.5	1.9	-0.4	-0.8	-1.4	-0.5	-0.3	0.1	-0.4	-0.9	-0.9	-0.7	-0.1	1.0
Ever smoked	0.8	1.4	2.6	1.0	1.6	0.8	1.4	1.5	-1.2	1.3	-1.1	0.8	1.6	0.8	0.2
Basal metabolic rate	0.2	0.8	3.9	-0.2	0.2	-1.2	-0.6	-2.0	0.7	-0.3	-0.8	-0.9	0.3	-1.0	-1.2
Leg fat percentage (left)	0.3	1.0	6.1	0.0	0.1	-1.3	0.2	-0.1	-0.4	0.4	-2.5	-0.7	1.7	0.2	0.2
Arm fat-free mass (left)	0.2	0.8	4.2	-0.1	0.5	-0.8	-0.4	-2.0	0.5	-0.1	-1.2	-0.5	0.6	-0.8	-1.1
Number of operations (self-reported)	0.2	0.3	1.0	-0.1	0.1	-0.8	0.0	0.5	-0.2	0.2	-0.8	0.5	1.0	-0.2	0.6
Average weekly beer plus cider intake	0.8	1.1	5.3	-1.0	-0.4	-1.4	-0.6	-0.4	0.9	-0.8	0.5	-0.2	-0.7	2.3	-1.4
Irritability	1.3	2.1	7.1	1.3	1.6	1.1	1.5	1.7	-1.2	1.2	0.9	2.7	1.9	0.6	0.6
Risk taking	1.0	1.4	2.6	-1.0	-1.6	-1.5	-1.6	-1.0	1.3	-1.4	-1.3	-0.4	-1.3	0.7	0.1
Ever had prostate specific antigen (PSA) test	2.2	2.5	4.6	2.1	1.3	1.8	2.0	1.0	-1.9	2.1	0.2	0.4	1.0	1.9	1.6
Fractured/broken bones in last 5 years	0.6	0.8	2.8	-0.5	-1.1	-0.3	-0.3	-0.3	0.5	-0.3	-1.7	-1.6	-0.8	-1.2	-0.2
Age started oral contraceptive pill	0.8	1.1	2.5	1.1	1.0	1.3	1.1	1.4	-0.9	1.1	0.7	1.6	0.3	-0.3	-0.4
Diastolic blood pressure, automated reading	0.1	0.4	2.4	0.5	-0.3	-0.7	0.5	0.2	-0.6	0.6	-1.5	-0.0	0.4	0.4	0.4
Ever depressed for a whole week	0.6	0.7	2.9	-0.6	-0.9	0.1	-0.5	-0.8	0.7	-0.8	1.3	1.7	-0.6	-0.3	-0.0
Unable to work because of sickness or disability	0.3	0.4	1.8	0.3	-0.0	0.9	0.3	0.2	-0.2	0.1	0.6	1.3	0.8	0.9	0.2
Commuting to job workplace: Cycle	0.8	1.0	6.5	-0.7	-0.5	0.1	-0.7	0.6	0.7	-0.8	2.5	-1.0	-0.8	-0.9	0.8
Myopia	1.1	1.5	3.5	1.5	1.2	0.1	1.2	1.9	-1.3	1.5	1.4	-1.3	1.5	0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.5	0.6	0.6	1.6	0.7	0.4	-0.0	0.3	-0.0	0.7	-0.3	-0.9	-0.7
Cholesterol lowering medication	0.4	0.5	2.6	-0.4	0.0	-0.1	0.2	-0.8	-0.2	-0.0	-0.8	-0.1	1.4	0.6	1.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	9.0	-1.2	-1.5	-1.5	-1.5	-1.1	1.0	-1.4	-0.4	-1.0	-0.4	0.1	3.0
Pain experienced in last month	4.6	7.7	19.1	-3.0	-3.1	-2.4	-2.4	-2.5	3.1	-2.7	0.1	-4.4	-1.9	-3.6	-1.8
Supplements: Calcium	0.5	0.5	1.6	0.2	-0.1	-1.3	-0.3	-1.1	-0.2	0.1	-1.1	-0.1	-0.9	0.7	-0.9
Basal cell carcinoma (self-reported)	0.1	0.2	1.2	-0.3	0.1	-0.4	-0.2	-0.3	0.0	-0.1	-0.2	0.4	0.2	0.2	-1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.5	-0.3	-0.3	-0.7	0.0	0.8	-0.0	-0.0	1.2	0.8	1.0	-0.9	1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.7	-0.6	-0.6	0.2	-1.2	-0.6	0.8	-0.9	-1.1	-0.3	-1.0	-1.3	-0.0
Heart disease (siblings)	0.8	0.9	3.6	-0.3	0.9	0.7	0.2	1.0	0.1	0.1	-1.5	-1.9	0.0	-1.4	-1.1
Alcohol drinker status: Previous	0.8	0.9	5.9	-0.1	-0.7	-1.1	-0.3	-0.9	0.4	-0.4	-1.3	-2.4	-0.5	-0.1	0.3
Pack years of smoking	0.3	0.5	1.8	0.4	1.3	-0.8	-0.0	0.5	-0.6	0.3	-0.7	1.1	-0.1	0.6	0.4
Impedance of whole body	0.2	0.8	4.5	-0.1	-1.5	0.1	-0.5	0.6	-0.1	-0.5	1.5	-0.1	-0.6	0.2	2.1
Leg fat mass (left)	0.2	0.8	4.3	0.4	0.5	-1.0	0.4	-0.6	-0.5	0.6	-2.1	-0.6	1.5	0.2	-0.5
Arm predicted mass (left)	0.1	0.6	2.6	0.3	0.8	-0.6	0.0	-1.6	0.2	0.3	-1.0	-0.3	0.9	-0.5	-1.0