Hub : Genes

WDR4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.3360 0.0970 2.8e-03 0.223 NA 0.199 NA 0.211 7.8e-08 NA 4.4e-07 NA 1.8e-07
2 GTEx Cells Transformed fibroblasts 0.1600 0.0590 2.4e-03 0.052 NA 0.013 NA 0.021 9.1e-05 NA 3.6e-02 NA 9.4e-03
3 GTEx Nerve Tibial 0.1514 0.0553 8.2e-03 -0.004 NA 0.004 NA -0.004 7.9e-01 NA 1.5e-01 NA 7.8e-01
4 GTEx Testis 0.1770 0.0570 4.3e-04 0.141 NA 0.114 NA 0.119 8.1e-07 NA 1.0e-05 NA 6.2e-06
5 METSIM Adipose 0.0583 0.0211 1.2e-03 0.022 0.016 0.011 0.016 0.007 2.1e-04 1.7e-03 8.1e-03 1.7e-03 2.4e-02
6 YFS Blood 0.0624 0.0160 8.4e-08 0.015 0.028 0.036 0.037 0.038 8.8e-06 1.3e-09 5.2e-12 2.9e-12 1.2e-12
7 TCGA Head and Neck Squamous Cell Carcinoma 0.0928 0.0529 3.5e-04 0.015 0.019 0.022 NA 0.019 7.2e-03 3.0e-03 1.3e-03 NA 3.1e-03
8 TCGA Brain Lower Grade Glioma 0.0743 0.0371 6.3e-04 0.045 0.021 0.022 NA 0.033 6.8e-06 1.8e-03 1.3e-03 NA 1.1e-04
9 TCGA Liver Hepatocellular Carcinoma 0.3070 0.1150 1.7e-04 0.015 0.094 0.083 NA 0.065 6.1e-02 3.5e-05 1.0e-04 NA 5.6e-04
10 TCGA Lung Squamous Cell Carcinoma 0.0643 0.0286 7.9e-04 0.044 0.028 0.037 NA 0.039 8.0e-06 3.1e-04 4.7e-05 NA 2.7e-05
11 TCGA Ovarian Serous Cystadenocarcinoma 0.1950 0.0970 5.1e-04 0.036 0.053 0.068 NA 0.072 1.6e-03 1.7e-04 2.3e-05 NA 1.3e-05
12 TCGA Prostate Adenocarcinoma 0.0456 0.0262 7.9e-03 0.011 0.016 0.022 NA 0.010 2.3e-02 7.9e-03 2.1e-03 NA 2.9e-02
13 TCGA Thyroid Carcinoma 0.1340 0.0490 8.1e-07 0.038 0.067 0.076 NA 0.071 1.2e-04 4.6e-07 7.2e-08 NA 2.0e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 2.3 3.6 9.1 -2.3 0.9 0.0 -0.5 -1.4 -1.5 -2.7 1.5 -2.6 -1.7 -3.0 -1.3 -2.7
Bipolar Disorder or Schizophrenia 1.2 2.8 8.2 -2.1 1.1 0.0 -0.6 -1.7 -0.8 -2.0 1.3 -2.5 -1.1 -2.9 -1.2 -2.0
Depressed Affect (Nagel 2018) 1.0 2.2 5.4 -2.3 1.4 0.0 1.1 -0.5 -0.4 -0.5 1.8 -1.8 -1.4 -2.1 -1.6 -1.9
Depression (Nagel 2018) 1.3 2.0 3.5 -1.8 1.0 0.0 0.3 -1.5 -0.9 -0.8 1.7 -1.8 -1.6 -1.9 -1.6 -1.8
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.2 0.3 -0.9 0.0 1.5 1.0 -0.7 -0.2 0.3 -0.3 -0.7 0.7 -1.3 0.5
Neuroticism (Nagel 2018) 0.4 1.0 2.3 -1.5 0.6 0.0 1.3 0.0 0.1 -0.3 1.1 -1.4 -0.9 -1.3 -1.3 -1.2
Schizophrenia (2018) 0.2 0.5 1.5 -0.9 0.8 0.0 -0.4 -1.1 0.1 -0.4 0.4 -1.1 -0.1 -1.2 -0.5 -0.4
Schizophrenia vs Biploar Disorder 0.8 1.0 3.0 1.3 -0.8 0.0 0.9 1.1 0.6 1.0 -0.5 1.1 0.6 1.7 -0.1 1.6
Worry (Nagel 2018) 0.2 0.4 1.5 -0.6 -0.5 0.0 0.4 0.0 0.3 -0.9 0.4 -1.1 -0.2 -1.2 -0.4 -0.8
Alzheimer’s Disease (in mother) 0.4 0.5 2.8 0.2 -1.7 0.0 -0.3 -0.9 -1.0 -1.1 0.1 -0.5 -0.4 0.0 -0.5 -0.2
Alzheimer’s Disease (in father) 0.7 0.8 3.8 0.2 -1.0 0.0 -0.9 -0.7 -0.1 -2.0 -0.5 -0.7 0.4 -1.2 0.6 -1.1
Alzheimer’s Disease (including proxy) 0.3 0.4 2.6 0.7 -1.6 0.0 -0.4 0.0 -0.1 -1.1 -0.7 -0.6 0.4 -0.0 0.3 -0.1
Crohns Disease (2017) 0.3 0.7 2.2 0.2 -0.5 0.0 1.0 1.2 1.5 -0.4 -1.1 -0.4 1.1 -0.6 0.7 -0.1
Irritable Bowel Disease (IBD) 0.3 0.7 3.3 -0.6 0.6 0.0 1.3 1.8 1.2 0.5 -0.2 -0.7 0.3 -0.5 -0.2 -0.2
Ulcerative Colitis (UC) 0.3 0.6 3.2 -0.6 1.0 0.0 1.2 1.8 1.0 0.8 0.1 -0.5 0.2 -0.1 -0.4 -0.0
Major Depression (MDD) 0.9 1.1 3.1 -1.4 0.8 0.0 1.6 0.6 0.0 -0.9 0.7 -1.8 -0.5 -1.4 -1.1 -1.0
Reaction Time 0.6 1.1 5.2 0.8 0.4 0.0 0.2 0.5 2.3 0.8 -1.4 -0.3 1.8 -0.0 1.2 0.8
Verbal and Numeric Reasoning (VNR) 0.7 1.7 4.3 -1.5 0.6 0.0 0.6 0.6 -1.8 -0.8 1.9 -1.2 -1.9 -0.6 -2.1 -1.0
Breast Cancer 0.4 1.0 2.1 0.8 0.8 0.0 -0.3 0.6 1.3 1.4 -1.1 1.1 1.2 0.3 1.4 1.3
Ovarian Cancer 0.5 0.7 3.0 0.2 -0.3 0.0 -1.7 -1.7 -0.1 0.9 -0.2 1.0 -0.1 0.4 0.7 0.4
Prostate Cancer 0.6 0.8 2.4 -0.1 0.1 0.0 1.5 0.8 -0.8 0.9 1.0 0.3 -0.7 1.6 -1.3 0.9
Age at First Birth 2.5 3.6 8.0 -2.2 1.4 0.0 -1.3 -0.2 -2.5 -1.6 2.4 -1.9 -2.8 -2.0 -1.6 -2.3
Bipolar Disorder (2011) 0.8 0.8 3.6 0.0 0.0 0.0 0.0 0.0 -0.1 -0.7 0.0 -1.9 -0.5 -1.9 -0.6 -1.3
Body Mass Index (BMI) (2010) 0.3 0.4 2.0 -0.1 0.1 0.0 1.4 1.2 -0.5 0.1 0.5 0.3 -0.5 0.4 -0.6 0.2
Coronary Artery Disease (CAD) 0.3 0.4 1.3 -0.3 1.2 0.0 -0.4 0.4 -0.6 1.1 0.5 0.3 -0.9 0.6 -0.5 0.4
Crohns Disease (2012) 0.4 0.6 2.6 0.3 -0.4 0.0 0.4 0.2 1.6 0.6 -1.4 0.0 1.2 -0.4 1.0 0.2
Mean Putamen Volume 0.2 0.2 0.8 -0.6 0.6 0.0 0.4 -0.5 0.2 -0.1 0.2 -0.4 -0.2 -0.9 -0.1 -0.8
Fasting Glucose 0.8 1.0 6.7 0.8 -0.2 0.0 1.0 2.6 0.3 0.5 -0.5 0.3 0.4 1.4 -0.3 1.2
HbA1C 5.7 6.3 17.1 3.5 -1.3 0.0 -2.0 0.1 2.5 -0.2 -4.1 2.8 3.4 1.0 4.1 2.1
HDL Cholesterol 0.1 0.2 1.0 -0.2 0.1 0.0 -1.0 -0.7 0.2 0.1 -0.2 -0.2 0.3 -0.2 0.5 -0.2
LDL Cholesterol 0.6 0.9 1.9 -1.2 0.2 0.0 0.7 -0.5 -0.6 -0.9 1.1 -1.2 -1.2 -1.0 -1.4 -1.2
Lupus 1.1 1.6 4.7 -1.8 2.0 0.0 -1.9 -0.2 -0.1 -0.7 0.8 -0.7 -0.3 -2.2 0.4 -2.1
Neuroticism (2016) 0.6 0.9 2.6 -0.8 1.6 0.0 1.6 -0.0 1.5 1.3 0.8 -0.7 0.3 -0.5 -0.3 -0.4
Primary Biliary Cirrhosis 1.0 1.4 3.4 1.7 -1.8 0.0 -0.9 -0.5 0.5 -0.6 -1.5 1.1 1.8 0.7 1.8 0.7
Rheumatoid Arthritis 0.1 0.2 0.5 0.2 -0.2 0.0 0.7 -0.7 0.6 -0.1 -0.5 -0.1 0.3 0.0 0.0 0.6
Schizophrenia (2014) 0.4 0.8 2.8 -1.3 0.8 0.0 -0.4 -0.5 -0.5 -0.9 0.8 -0.9 -0.9 -1.7 -0.9 -0.9
Triglycerides 0.4 0.7 4.6 0.2 -0.2 0.0 2.2 1.7 -0.1 -0.0 0.1 0.1 -0.4 0.3 -1.1 0.6
Type 2 Diabetes (T2D) (2012) 1.8 2.1 4.7 1.7 -0.5 0.0 1.7 1.7 1.7 1.3 -1.5 0.9 1.6 1.8 0.6 2.2
Ulcerative Colitis 0.9 1.3 4.5 -1.3 2.1 0.0 1.5 1.8 0.9 1.4 0.7 -0.5 -0.4 -0.2 -0.9 0.3
Blood Eosinophil Count 0.0 0.1 0.8 0.4 0.4 0.0 -0.9 0.3 -0.2 0.3 -0.2 0.2 0.3 0.4 0.5 0.3
Blood Platelet Count 0.0 0.3 1.2 -0.1 0.0 0.0 -0.4 0.5 -0.7 1.1 0.6 0.2 -0.9 0.7 -0.5 0.1
Blood Red Count 0.1 0.7 3.9 0.3 -1.4 0.0 -0.5 -1.1 -1.2 -2.0 -0.1 0.0 0.1 -0.3 -0.1 -0.5
Blood White Count 0.5 3.7 10.5 -2.9 3.2 0.0 -0.6 -1.7 -0.8 -0.2 2.1 -2.1 -1.5 -2.7 -1.1 -2.4
Heel T-Score 0.4 2.9 11.2 2.2 -3.3 0.0 1.7 1.6 1.1 -0.5 -2.0 1.1 1.9 1.4 1.0 1.7
BMI 0.2 1.0 5.2 -0.0 -1.6 0.0 0.2 0.5 -2.3 -1.0 0.9 0.9 -0.9 0.8 -0.9 -0.0
Height 0.1 2.1 6.5 -0.5 -0.5 0.0 -0.4 -2.5 1.2 -1.5 -0.6 -2.5 0.7 -2.5 0.5 -1.8
Waist Hip Ratio (WHR) 0.1 0.3 2.0 -0.3 0.1 0.0 -1.4 -0.2 -0.4 -0.8 0.4 -0.4 -0.3 -0.6 -0.0 -0.4
Systolic Blood Pressure 0.4 2.0 5.5 -1.6 0.8 0.0 1.2 1.7 -1.5 0.3 2.2 -0.9 -2.0 -0.2 -2.4 -0.7
Smoking Status 0.5 1.2 5.6 -0.8 0.1 0.0 -1.2 -2.4 0.2 -1.1 0.2 -1.2 0.1 -1.9 0.5 -1.2
Allergy or Eczema 0.2 0.6 1.9 0.8 0.1 0.0 -1.3 -0.3 0.7 0.4 -0.9 1.1 0.8 0.2 1.4 0.8
Cardiovascular Disease 0.3 0.9 2.3 -1.0 -0.3 0.0 0.2 0.6 -1.5 -0.6 1.3 -0.5 -1.5 -0.4 -1.4 -0.9
Hypothyroidism (self reported) 0.2 0.4 1.2 0.2 -0.1 0.0 -1.1 -0.3 0.7 -0.5 -0.7 0.6 0.8 -0.2 1.0 0.2
Respiratory disease 0.8 1.7 7.4 -0.8 -0.9 0.0 0.1 -0.5 -2.7 -0.8 1.7 -1.0 -2.0 0.0 -2.1 -0.7
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.6 -0.3 -0.6 0.0 -0.8 -0.8 -0.9 -1.6 -0.1 -0.5 -0.2 -0.9 0.3 -1.3
Lung FEV1/FVC ratio 0.2 0.8 4.7 0.1 -0.1 0.0 -2.2 -1.3 0.5 -0.6 -0.6 0.2 0.5 -0.8 1.3 -0.5
Lung FVC 1.0 5.3 11.0 -3.2 2.1 0.0 -0.2 0.2 -2.3 -0.1 3.3 -3.1 -3.2 -1.7 -3.3 -2.3
Neuroticism 0.2 0.4 1.6 -0.6 -0.3 0.0 1.3 0.1 0.1 -0.1 0.6 -0.9 -0.6 -0.5 -1.0 -0.4
Chronotype (morning person) 0.2 0.6 1.9 0.4 -0.0 0.0 -0.6 -0.6 1.2 -0.5 -0.9 -0.3 1.4 -0.6 1.2 -0.1
Hair Pigment 0.2 5.0 45.9 -0.7 -1.0 0.0 -1.4 -6.8 -1.1 -2.6 0.7 -1.4 -0.8 -1.3 -0.7 -1.6
Tanning 0.3 3.9 10.8 -1.3 -1.7 0.0 -0.7 -0.7 -1.7 -3.1 1.2 -3.2 -1.4 -2.2 -1.5 -3.3
Hand grip strength (left) 0.2 0.6 2.1 0.2 -1.3 0.0 -0.5 -1.0 -0.2 -1.5 -0.5 -0.9 0.2 -0.8 0.1 -0.7
Number of treatments/medications taken 0.5 0.9 2.0 -0.9 -0.4 0.0 -0.7 -1.4 -1.0 -0.9 1.1 -1.2 -1.1 -0.9 -0.8 -1.4
Average weekly spirits intake 0.6 0.7 3.6 -0.8 0.5 0.0 -0.7 -1.9 0.0 -0.4 0.2 -0.6 0.0 -1.2 0.4 -1.4
Sensitivity / hurt feelings 0.5 0.9 3.8 0.3 -1.9 0.0 -0.2 -0.1 -1.5 -1.4 0.4 -1.1 -0.7 0.1 -1.1 -0.7
Frequency of depressed mood in last 2 weeks 2.0 2.7 4.8 -2.2 1.5 0.0 0.2 -1.6 -1.1 -1.2 1.9 -2.2 -1.9 -2.0 -1.9 -1.9
Hearing difficulty/problems: Yes 0.7 1.1 5.4 -0.2 -0.8 0.0 1.8 -0.4 0.4 -1.7 -0.0 -2.3 0.3 -0.9 -1.0 -0.5
Relative age of first facial hair 0.5 0.9 4.2 -1.4 2.1 0.0 -0.5 -0.6 0.6 0.8 0.5 -0.7 0.0 -1.5 0.4 -1.2
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 10.0 -0.2 -0.4 0.0 -3.2 -2.4 -0.2 -1.2 -0.2 -0.3 0.1 -1.6 1.3 -1.4
Ever used hormone-replacement therapy (HRT) 1.2 1.5 5.9 0.0 0.2 0.0 -1.8 -2.4 1.0 -1.0 -1.1 -0.1 1.0 -1.7 1.7 -0.9
Ever had hysterectomy (womb removed) 1.1 1.3 4.2 -0.2 -1.0 0.0 -1.3 -0.5 0.1 -2.0 -0.4 -1.3 0.5 -1.9 0.8 -1.7
Systolic blood pressure, automated reading 0.3 1.0 2.6 -1.4 0.8 0.0 0.3 0.4 -1.0 -0.0 1.6 -1.1 -1.2 -0.8 -1.4 -1.2
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 3.0 -0.4 -1.4 0.0 -0.1 -1.5 -1.7 -1.7 0.6 -0.1 -1.1 -0.4 -1.0 -0.7
Angina 0.9 1.1 4.0 0.2 -1.4 0.0 -1.8 -0.8 -2.0 -1.7 0.4 -0.0 -0.9 0.1 -0.6 -0.4
Medication for hormone replacement therapy 0.5 0.5 1.6 -1.1 1.3 0.0 0.4 -0.5 0.0 0.5 0.7 -0.7 -0.9 -1.0 -0.5 -0.5
Vitamin and mineral supplements 1.0 1.3 2.8 0.8 0.2 0.0 1.6 1.7 1.3 1.4 -0.7 1.4 1.2 1.3 0.7 1.3
Supplements: Zinc 0.3 0.3 1.2 0.7 -0.8 0.0 -1.1 -0.2 -0.4 0.0 -0.4 0.2 0.4 0.4 0.1 0.7
Medication: Co-codamol 0.5 0.6 1.8 0.6 0.1 0.0 1.1 1.3 0.8 0.7 -0.8 1.1 0.7 0.5 0.8 0.3
Medication: Metformin 0.4 0.6 2.1 -0.9 0.5 0.0 -0.4 -0.3 -1.0 -1.1 0.6 -0.4 -0.9 -1.1 -0.2 -1.5
Diabetes (father) 0.4 0.5 2.2 -0.4 1.3 0.0 0.3 0.1 1.5 0.5 -0.3 -0.9 0.6 -0.6 0.7 -0.4
Diabetes (mother) 0.1 0.1 0.8 -0.1 0.2 0.0 0.5 0.2 0.1 -0.7 -0.2 -0.1 0.4 -0.3 0.3 -0.9
Severe depression (siblings) 0.3 0.3 1.2 -0.1 -0.7 0.0 0.7 -0.7 -0.6 -1.1 0.3 -0.5 -0.1 -0.0 -0.5 -0.7
Pack years adult smoking proportion 0.7 1.0 3.1 -1.3 0.5 0.0 -0.8 -1.3 -0.4 -1.5 0.6 -0.9 -0.5 -1.8 -0.2 -1.2
Impedance of leg (right) 0.5 2.2 8.4 -2.1 2.9 0.0 -1.7 -1.5 0.1 0.5 1.3 -0.9 -1.1 -2.0 -0.3 -1.6
Leg fat-free mass (left) 0.3 1.7 4.6 -0.6 -1.9 0.0 1.2 0.3 -2.0 -2.2 1.0 -1.1 -1.1 -0.5 -1.6 -1.0
Trunk fat percentage 0.5 2.2 5.6 -1.6 -0.3 0.0 0.4 -0.7 -1.4 -2.4 1.1 -2.1 -1.1 -2.0 -1.4 -2.1
Hand grip strength (right) 0.2 0.6 1.8 0.6 -1.3 0.0 0.1 -0.8 0.3 -1.2 -0.9 -1.1 0.8 -0.6 0.4 -0.7
Townsend deprivation index at recruitment 0.6 0.9 5.2 0.4 -1.4 0.0 -0.5 -1.2 -0.2 -2.3 -0.7 -0.4 0.2 -0.9 0.5 -0.6
Current tobacco smoking 0.5 0.9 2.6 0.3 -1.0 0.0 -1.4 -1.1 -0.1 -1.6 -0.9 0.2 0.7 -1.0 1.2 -0.7
Average weekly fortified wine intake 1.3 1.5 5.7 0.3 -2.2 0.0 -1.0 -1.6 -0.8 -2.4 -0.0 -1.5 -0.2 -0.9 -0.3 -0.9
Maternal smoking around birth 1.5 2.2 4.4 -1.8 -0.1 0.0 -0.5 -0.4 -2.0 -2.1 1.7 -1.4 -1.6 -1.7 -1.5 -2.1
Fed-up feelings 0.2 0.3 2.0 -0.7 1.4 0.0 0.4 -0.1 0.4 0.6 0.5 -0.3 -0.2 -0.6 -0.1 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 1.2 -0.2 -0.1 0.0 -0.7 -1.1 -0.6 -0.5 0.2 0.2 -0.4 -0.5 0.1 -0.6
Relative age voice broke 0.5 0.7 2.4 -0.4 0.7 0.0 -1.4 -0.5 0.7 -0.6 -0.5 -0.7 0.8 -1.6 1.1 -1.1
Taking other prescription medications 0.2 0.4 2.0 0.2 -0.4 0.0 -0.8 -1.4 0.4 -0.4 -0.5 -0.4 0.6 -0.5 0.6 -0.1
Age when periods started (menarche) 0.4 0.9 3.8 0.1 -0.6 0.0 -1.9 -1.5 -0.2 -1.0 -0.6 -0.4 0.4 -1.3 1.0 -1.1
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.4 -0.5 -0.3 0.0 1.1 0.5 0.3 -1.1 -0.2 -0.5 0.1 -1.2 -0.0 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 8.0 2.3 -1.3 0.0 0.9 0.8 2.1 0.2 -2.4 2.8 2.3 1.7 2.2 1.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 -0.5 0.2 0.0 0.3 -0.2 -0.6 0.5 0.6 -0.1 -0.5 0.1 -0.7 0.0
Qualifications: CSEs or equivalent 1.4 1.8 3.6 -1.6 1.0 0.0 -1.5 -0.6 -1.9 -0.9 1.9 -0.8 -1.7 -1.4 -1.1 -1.8
Serious illness, injury or assault to yourself 1.0 1.2 2.6 1.6 -0.6 0.0 -1.2 0.1 0.1 0.6 -1.2 1.6 1.0 1.5 1.5 1.1
High blood pressure 0.5 1.3 2.9 -1.6 0.4 0.0 0.0 -0.1 -0.8 -0.9 1.5 -1.7 -1.2 -1.4 -1.2 -1.7
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.2 1.6 -0.9 0.0 -1.3 -0.7 0.6 0.3 -1.5 1.5 1.4 0.8 1.8 1.2
Multivitamins +/- minerals 1.3 1.7 4.1 -0.9 -0.9 0.0 -1.3 -1.4 -1.9 -2.0 0.9 -1.5 -1.4 -1.2 -1.1 -1.3
Stomach or abdominal pain in last month 0.6 0.8 2.6 -1.2 1.1 0.0 -1.6 -0.7 -0.8 0.5 1.1 -0.9 -1.0 -0.6 -0.6 -0.4
Supplements: Glucosamine 1.3 1.7 5.1 -0.8 -1.3 0.0 -0.9 -0.7 -2.3 -2.1 1.2 -0.9 -1.6 -1.0 -1.3 -1.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.5 0.2 0.1 0.0 -0.0 -0.2 1.2 -0.1 -0.9 -1.2 0.7 -0.8 0.5 0.6
Medication: Atenolol 0.1 0.2 0.7 0.5 -0.9 0.0 -0.1 0.0 -0.5 -0.8 -0.1 0.3 0.1 0.4 -0.2 0.2
Medication: Levothyroxine sodium 0.3 0.4 1.9 0.3 -0.1 0.0 -0.1 0.6 1.4 -0.3 -0.9 0.4 1.0 -0.5 0.9 0.1
Sitting height 0.7 5.1 11.5 -3.1 1.4 0.0 0.1 -0.2 -1.9 -0.6 3.2 -3.4 -3.0 -2.2 -3.2 -2.2
Chronic bronchitis/emphysema (father) 0.6 0.7 2.7 0.6 0.4 0.0 0.2 0.3 1.7 0.9 -0.9 0.7 1.2 0.2 1.2 0.6
High blood pressure (mother) 0.3 0.4 2.0 0.5 -0.4 0.0 0.2 0.1 -0.6 0.8 0.2 1.4 -0.2 1.3 -0.1 0.6
Body mass index (BMI) 0.3 1.3 3.9 -1.0 -0.8 0.0 0.8 -0.1 -1.6 -2.0 1.1 -1.2 -1.0 -1.0 -1.4 -1.3
Impedance of leg (left) 0.5 2.3 9.5 -2.1 3.1 0.0 -1.6 -1.4 0.3 0.6 1.2 -0.9 -1.1 -2.1 -0.3 -1.5
Leg predicted mass (left) 0.3 1.6 4.6 -0.6 -1.9 0.0 1.2 0.3 -2.0 -2.2 1.0 -1.1 -1.0 -0.5 -1.6 -1.0
Trunk fat mass 0.6 2.6 6.4 -1.7 -0.6 0.0 0.6 -0.6 -1.8 -2.5 1.4 -2.1 -1.4 -1.9 -1.7 -2.1
Waist circumference 0.3 0.9 4.4 -0.3 -1.6 0.0 0.3 -0.8 -0.8 -2.1 0.0 -1.3 -0.1 -1.0 -0.5 -0.9
Number of incorrect matches in round 0.7 1.1 4.9 0.3 0.2 0.0 -0.4 -1.7 2.2 0.4 -1.2 -0.7 1.4 -0.8 1.2 0.3
Past tobacco smoking 0.6 1.0 6.8 1.0 -0.5 0.0 0.6 2.6 -0.4 0.4 -0.2 1.2 -0.0 1.4 0.1 1.0
Alcohol usually taken with meals 1.9 3.1 7.0 2.4 -1.3 0.0 -0.9 -0.2 2.4 1.2 -2.6 0.8 2.5 1.1 2.6 1.6
Nervous feelings 0.3 0.6 2.5 0.1 0.2 0.0 0.8 1.6 -0.3 1.0 0.8 0.7 -0.6 1.1 -0.7 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.7 -0.7 0.9 0.0 -0.1 -0.2 -0.8 0.3 1.1 -0.1 -1.3 -0.1 -0.9 -0.4
Hearing difficulty/problems with background noise 0.6 1.0 3.9 0.5 -1.8 0.0 0.4 -0.6 0.3 -2.0 -0.8 -1.6 0.6 -0.9 -0.1 -0.7
Hair/balding pattern: Pattern 2 0.1 0.2 0.7 -0.5 0.3 0.0 0.7 0.8 -0.2 -0.1 0.5 -0.0 -0.4 0.2 -0.7 0.0
Had menopause 1.2 1.4 5.1 1.3 0.2 0.0 -0.4 0.1 2.3 0.3 -1.9 0.3 1.9 -0.1 1.9 1.1
Had other major operations 0.8 1.0 3.2 0.5 -0.6 0.0 -1.8 -1.7 -0.0 -1.2 -0.7 0.9 0.8 -0.6 1.5 -0.3
Forced vital capacity (FVC) 0.8 3.0 8.8 -2.3 1.1 0.0 0.9 0.4 -1.9 -0.1 2.5 -1.9 -2.6 -1.1 -3.0 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 10.2 2.5 -1.3 0.0 0.9 1.1 1.8 1.0 -2.3 3.2 2.1 2.3 2.1 2.5
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 3.7 -1.0 0.5 0.0 -0.1 -1.9 0.4 -0.3 0.3 -1.5 -0.0 -1.4 0.0 -1.2
Qualifications: None of the above 2.0 4.3 12.7 -2.4 0.6 0.0 -0.2 -1.1 -0.6 -3.2 1.3 -2.9 -1.1 -3.6 -1.1 -3.5
Financial difficulties in last 2 years 0.3 0.5 1.7 -0.8 0.0 0.0 0.4 -0.4 -0.9 -0.1 0.8 -0.2 -1.3 -0.1 -1.3 0.4
Mouth/teeth dental problems 0.8 1.2 3.1 -1.4 1.3 0.0 -0.1 0.0 -1.2 0.3 1.8 -0.9 -1.7 -0.3 -1.6 -0.6
Heart attack 0.4 0.5 1.0 -1.0 0.7 0.0 -0.7 0.2 -0.5 -0.8 0.6 -1.0 -0.6 -1.0 -0.6 -0.9
Allergy 0.4 1.0 3.7 -1.1 1.2 0.0 1.9 1.2 0.4 0.0 0.8 -1.1 -0.6 -0.5 -1.3 -0.5
Pain all over the body in last month 0.9 0.9 3.0 1.1 -0.3 0.0 1.0 1.3 0.1 1.3 -0.5 1.2 0.2 1.7 0.2 1.5
Diabetes (self-reported) 0.4 0.6 1.7 -0.6 -0.6 0.0 -0.5 -0.4 -1.3 -1.3 0.6 -0.2 -0.9 -0.7 -0.4 -1.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.4 -0.1 0.6 0.0 -0.3 -0.1 0.4 0.6 0.1 -0.3 0.2 -0.1 0.0 0.5
Medication: Ramipril 0.5 0.7 2.8 0.2 -1.7 0.0 0.3 1.0 -1.3 -0.9 0.2 -0.6 -0.8 0.1 -1.3 0.2
Medication: Simvastatin 1.3 2.0 4.5 -1.2 -0.7 0.0 -0.2 -0.5 -1.8 -2.1 1.3 -1.9 -1.5 -1.3 -1.5 -1.9
Fluid intelligence score 0.2 0.3 0.8 0.1 -0.7 0.0 0.8 0.3 -0.9 -0.8 0.3 -0.4 -0.4 0.4 -0.9 0.2
Illnesses of siblings 0.4 0.5 1.2 0.6 0.3 0.0 -1.1 -1.0 0.7 0.6 -0.6 1.1 0.6 0.3 1.0 0.7
Neuroticism score 0.5 1.0 2.4 -1.4 0.3 0.0 0.6 0.0 -0.6 -0.6 1.3 -1.6 -1.3 -1.2 -1.4 -1.2
Weight 0.4 2.1 5.4 -1.3 -1.2 0.0 0.9 -0.5 -1.9 -2.3 1.3 -1.8 -1.3 -1.4 -1.8 -1.7
Impedance of arm (right) 0.1 0.5 1.6 0.6 0.7 0.0 -0.3 0.5 1.3 1.1 -0.9 0.3 0.8 0.4 0.9 0.6
Arm fat percentage (right) 0.4 1.7 4.2 -1.4 -0.6 0.0 0.7 0.0 -1.9 -2.0 1.4 -1.3 -1.3 -1.1 -1.7 -1.5
Trunk fat-free mass 0.2 1.4 3.2 -0.9 -1.4 0.0 1.0 -0.2 -1.6 -1.8 1.2 -1.3 -1.1 -0.8 -1.7 -1.1
Hip circumference 0.2 1.0 3.2 -0.4 -1.3 0.0 1.3 -0.7 -0.5 -1.8 0.0 -1.5 -0.1 -1.1 -0.8 -0.9
Time employed in main current job 0.8 0.9 3.0 0.8 0.2 0.0 1.7 1.3 1.1 0.8 -0.8 0.7 0.8 1.3 0.2 1.2
Alcohol intake versus 10 years previously 0.9 1.4 4.2 1.3 -0.7 0.0 -1.0 -0.8 1.6 -0.4 -2.0 0.5 1.8 -0.0 2.0 0.4
Father’s age at death 0.5 0.6 1.9 -0.7 0.6 0.0 0.0 -1.4 0.6 -0.5 -0.1 -1.4 0.2 -1.4 0.1 -1.0
Worrier / anxious feelings 0.5 1.0 4.2 0.3 -2.0 0.0 -0.1 -1.3 -0.6 -2.0 -0.3 -0.9 -0.0 -0.6 -0.1 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.9 -0.4 0.2 0.0 -0.6 -1.4 0.3 -0.2 0.2 -0.1 -0.2 -0.7 0.2 -0.4
Falls in the last year 0.2 0.2 1.0 0.2 -0.1 0.0 -0.9 -1.0 0.3 -0.1 -0.4 0.2 0.4 -0.2 0.5 0.2
Hair/balding pattern: Pattern 3 0.2 0.3 1.1 0.1 -0.9 0.0 -1.0 -0.4 -0.9 -0.7 0.2 0.4 -0.5 -0.0 -0.0 -0.5
Number of live births 1.1 1.5 5.7 1.2 -0.5 0.0 0.2 1.1 2.4 -0.0 -1.7 0.1 2.1 0.0 1.8 0.8
Forced expiratory volume in 1-second (FEV1) 0.9 3.0 7.5 -2.4 1.5 0.0 0.4 0.4 -1.8 0.0 2.5 -1.9 -2.6 -1.2 -2.7 -1.3
Pulse rate 0.2 0.3 1.1 0.3 0.1 0.0 -0.6 -0.3 0.3 0.9 -0.5 1.1 0.3 0.5 0.7 0.5
Happiness 0.3 0.4 2.9 0.3 -0.0 0.0 1.7 -0.0 0.9 -0.0 -0.4 0.2 0.6 0.5 -0.1 0.9
Noisy workplace 0.2 0.2 0.7 0.2 -0.6 0.0 0.8 0.6 0.4 -0.2 -0.4 -0.7 0.3 -0.0 -0.3 0.0
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.0 0.6 -0.5 0.0 -0.7 -0.8 -0.4 0.4 -0.4 0.7 -0.0 0.7 0.1 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 4.1 -1.2 -0.2 0.0 -0.5 -0.3 -2.0 -1.5 1.4 -0.9 -1.4 -1.2 -1.3 -1.9
Mouth/teeth dental problems: Dentures 0.4 0.6 2.0 -0.6 0.5 0.0 0.3 -0.9 0.9 -1.1 -0.3 -0.9 0.5 -1.4 0.4 -1.2
Asthma 0.2 0.5 2.1 -0.2 -0.1 0.0 -0.5 -0.9 -1.4 0.4 0.9 0.0 -1.0 0.4 -0.8 -0.0
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 3.6 -1.0 -0.3 0.0 -1.7 -1.4 -1.9 -0.5 1.4 -0.1 -1.6 -0.8 -0.6 -1.0
Medication: Cholesterol lowering 2.3 3.6 6.1 -1.8 -0.7 0.0 -1.6 -2.4 -2.4 -2.5 2.0 -1.5 -2.2 -1.9 -1.7 -2.5
Depression (self-reported) 0.8 1.0 2.9 0.4 1.1 0.0 1.2 0.2 1.6 1.6 -0.5 -0.1 0.7 1.0 -0.0 1.7
Medication: Lansoprazole 0.7 0.8 3.5 -0.2 -1.0 0.0 -1.4 -1.9 -1.0 -1.1 0.3 -0.1 -0.1 -0.5 0.2 -0.9
Prospective memory result 1.0 1.2 3.9 -1.2 0.4 0.0 0.8 -0.3 -0.7 -0.5 1.2 -2.0 -1.3 -1.2 -1.6 -1.2
Lung cancer (father) 0.9 1.1 4.3 0.3 -2.0 0.0 0.2 0.5 -2.1 -1.9 0.4 0.4 -0.7 0.2 -1.0 -0.2
Illnesses of mother 0.3 0.3 1.3 0.2 -0.3 0.0 -1.1 -0.7 0.2 -0.8 -0.4 -0.4 0.5 -0.6 0.7 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.4 12.3 -2.8 1.7 0.0 1.2 1.5 -2.0 0.3 3.1 -2.1 -3.1 -1.1 -3.5 -1.3
Pulse wave Arterial Stiffness index 0.3 0.3 1.9 0.3 -1.4 0.0 0.1 0.2 -1.1 -0.6 0.1 0.3 -0.6 0.4 -0.4 -0.2
Impedance of arm (left) 0.1 0.5 1.1 0.7 0.6 0.0 -0.3 0.1 1.1 1.0 -0.8 0.5 0.9 0.6 1.0 0.7
Arm fat mass (right) 0.4 1.6 5.0 -1.1 -1.0 0.0 0.6 -0.2 -1.8 -2.2 1.1 -1.4 -1.0 -1.2 -1.4 -1.5
Trunk predicted mass 0.3 1.6 3.6 -1.0 -1.4 0.0 0.9 -0.2 -1.7 -1.9 1.2 -1.4 -1.2 -0.9 -1.7 -1.2
Standing height 0.1 1.4 3.7 -0.9 -1.2 0.0 0.1 -1.1 -1.1 -1.5 0.9 -1.9 -1.1 -1.3 -1.3 -1.4
Length of working week for main job 0.3 0.3 1.2 -0.0 -0.6 0.0 1.1 0.7 -0.3 -0.8 -0.3 -1.0 0.1 -0.2 -0.6 -0.4
Exposure to tobacco smoke at home 1.1 1.3 2.9 1.1 -0.6 0.0 -1.0 -1.7 0.8 0.6 -1.3 1.7 1.2 0.8 1.7 0.8
Breastfed as a baby 0.2 0.3 0.9 0.0 -0.0 0.0 0.4 -0.1 -0.9 0.9 0.7 0.3 -0.4 0.9 -0.6 0.1
Tense / ‘highly strung’ 0.5 0.9 2.5 -1.2 0.8 0.0 1.6 -0.2 0.1 -0.2 1.1 -1.5 -0.8 -1.1 -1.2 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 4.8 -0.9 -0.5 0.0 0.8 -1.5 -0.9 -2.2 0.6 -2.1 -0.6 -1.6 -1.0 -1.5
Hair/balding pattern: Pattern 4 0.3 0.7 2.1 0.3 0.2 0.0 -0.2 -0.7 1.4 -0.5 -1.1 -0.2 1.3 -1.0 1.3 -0.3
Birth weight of first child 0.4 0.8 2.7 1.3 -1.4 0.0 1.2 0.7 -0.2 0.2 -0.4 0.3 0.4 1.6 -0.4 1.2
Peak expiratory flow (PEF) 1.6 3.7 10.7 -2.4 1.0 0.0 1.2 0.6 -2.0 -0.8 2.7 -2.5 -2.7 -1.3 -3.3 -1.4
Pulse wave reflection index 0.1 0.1 0.6 0.2 -0.8 0.0 -0.2 -0.4 -0.5 -0.4 -0.0 0.4 -0.1 0.2 -0.0 -0.1
Ever highly irritable/argumentative for 2 days 1.4 1.7 3.9 -2.0 1.7 0.0 0.8 0.2 -0.1 -0.8 1.4 -1.8 -1.2 -1.6 -1.2 -1.7
Loud music exposure frequency 1.8 2.0 4.7 1.7 -1.6 0.0 -1.8 -1.4 0.2 -0.2 -1.7 2.2 1.2 1.1 1.9 1.0
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 4.6 -0.7 -0.1 0.0 -1.1 -0.8 -2.1 -0.5 1.1 0.1 -1.5 -0.2 -0.9 -0.7
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.9 0.2 -0.6 0.0 -0.9 -0.5 -0.5 -0.0 -0.0 0.7 -0.1 0.2 0.2 0.3
Blood clot in the leg (DVT) 0.6 0.8 2.8 -0.7 0.2 0.0 -1.7 -0.8 0.1 -1.4 0.1 -0.2 0.1 -1.5 0.7 -1.2
Medication: Paracetamol 0.9 1.5 6.7 -0.4 -1.0 0.0 -1.1 -2.6 -0.7 -1.6 0.0 -1.8 -0.3 -1.3 0.1 -1.4
Headache pain in last month 1.0 1.8 6.0 0.6 -0.3 0.0 -2.5 -2.4 1.2 -0.2 -1.4 -0.2 1.3 -1.2 2.1 -0.6
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 5.4 1.8 0.5 0.0 0.1 0.7 2.3 2.0 -2.3 1.8 2.3 1.4 2.3 2.3
Glaucoma (self-reported) 0.6 0.7 3.1 0.5 -0.6 0.0 1.8 0.9 0.5 0.7 -0.2 -0.1 0.4 1.3 -0.6 1.2
Gout (self-reported) 0.8 1.2 6.5 0.8 -0.5 0.0 2.6 0.6 1.5 0.6 -1.0 -0.4 0.8 0.6 -0.4 1.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.0 0.5 -0.5 0.0 -0.6 0.2 1.0 -0.3 -0.8 0.6 0.9 -0.1 1.0 0.2
Medication: Amlodipine 0.5 0.7 2.5 0.5 -1.1 0.0 1.6 1.1 -0.8 -1.0 0.1 0.2 -0.1 0.9 -0.8 0.3
Medication: Ventolin 100micrograms inhaler 0.6 0.8 3.1 0.0 -0.6 0.0 -1.7 -1.8 -1.2 -0.8 0.3 -0.4 -0.1 -0.7 0.3 -1.0
Birth weight 0.2 0.4 2.2 0.4 -1.1 0.0 0.0 -0.7 -0.7 -1.5 -0.0 -0.4 0.1 -0.1 -0.1 -0.5
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.5 -0.4 -1.6 0.0 -0.4 -0.9 -1.4 -1.4 0.4 -0.5 -0.6 -0.8 -0.4 -1.1
High blood pressure (siblings) 0.3 0.4 1.5 -0.7 -0.2 0.0 0.2 0.5 -1.2 -0.6 0.8 -0.3 -0.7 -0.3 -0.7 -0.9
Forced vital capacity (FVC), Best measure 1.2 4.6 13.4 -2.8 1.7 0.0 1.6 1.3 -2.0 0.3 3.2 -2.1 -3.2 -1.1 -3.7 -1.3
Body fat percentage 0.6 2.4 5.5 -1.9 -0.2 0.0 0.3 -0.7 -1.8 -2.3 1.5 -1.9 -1.4 -1.9 -1.6 -2.1
Leg fat percentage (right) 1.0 3.7 7.4 -2.7 0.7 0.0 0.1 -0.8 -2.2 -1.9 2.4 -2.1 -2.1 -2.3 -2.2 -2.5
Arm fat-free mass (right) 0.6 2.9 6.1 -1.8 -0.7 0.0 0.5 -0.6 -2.5 -2.2 2.1 -1.8 -2.0 -1.5 -2.3 -1.9
Exposure to tobacco smoke outside home 1.3 1.7 3.9 1.5 -0.3 0.0 -0.2 -0.4 1.5 0.9 -2.0 1.5 1.8 1.0 1.9 1.5
Comparative body size at age 10 1.0 2.7 8.1 2.4 -2.8 0.0 1.8 0.8 0.8 -0.9 -2.2 0.8 1.8 1.9 1.0 1.5
Number of full brothers 0.7 0.8 2.1 0.4 -1.5 0.0 -1.4 -0.6 -1.1 -1.3 -0.5 1.3 0.1 -0.5 0.9 -0.6
Worry too long after embarrassment 1.6 2.6 6.2 -1.9 -0.1 0.0 -0.3 -0.5 -1.7 -1.3 1.8 -2.4 -2.2 -1.7 -2.5 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 5.0 -0.9 -0.5 0.0 -0.7 -1.8 -0.2 -1.8 0.6 -2.2 -0.5 -2.0 -0.5 -1.6
Wheeze or whistling in the chest in last year 1.3 2.4 8.6 -0.7 -1.0 0.0 -2.6 -1.9 -2.9 -1.4 1.3 -0.5 -1.6 -0.8 -0.9 -1.4
Number of children fathered 0.7 0.8 2.8 0.9 -1.7 0.0 -0.0 -0.2 0.5 -1.2 -1.1 0.4 1.3 -0.3 1.2 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.3 1.7 -0.8 0.0 -0.9 0.2 1.1 0.5 -1.6 1.6 1.7 1.1 1.8 1.1
Age at first live birth 0.9 1.5 5.5 -0.3 1.8 0.0 1.6 2.3 0.4 2.0 0.6 0.9 -0.5 1.2 -0.6 1.0
Pulse wave peak to peak time 0.2 0.3 1.2 -0.2 1.1 0.0 0.0 -0.1 1.1 0.6 -0.2 -0.3 0.6 -0.3 0.4 0.3
Health satisfaction 1.3 1.7 3.7 -1.9 0.9 0.0 -1.0 -1.6 -1.6 -0.6 1.9 -0.6 -1.9 -1.2 -1.2 -1.2
Shortness of breath walking on level ground 0.8 0.9 2.0 -1.4 1.0 0.0 0.4 -0.2 -1.0 -0.2 1.3 -1.0 -1.3 -0.6 -1.4 -0.8
Qualifications: College or University degree 0.8 2.5 7.2 1.3 0.3 0.0 1.8 1.5 2.1 2.6 -1.1 0.5 1.1 1.8 0.3 2.7
Eye problems/disorders: None of the above 0.7 0.8 2.0 1.2 -0.5 0.0 -1.3 1.0 0.2 0.2 -0.9 1.4 0.8 0.8 1.4 0.4
Mouth/teeth dental problems: Loose teeth 0.3 0.4 2.5 0.1 -1.6 0.0 0.8 -0.4 -0.2 -1.0 -0.1 -0.5 -0.2 -0.3 -0.5 -0.3
Emphysema/chronic bronchitis 0.9 1.0 3.6 0.1 -1.9 0.0 -1.7 -0.5 -1.6 -1.5 0.3 -0.2 -0.7 -0.2 -0.3 -0.7
Medication for pain relief, constipation, heartburn 1.4 2.3 4.4 1.6 0.5 0.0 0.5 1.3 2.0 1.7 -1.6 2.1 2.0 1.4 1.7 1.8
Neck or shoulder pain in last month 1.9 2.7 14.1 0.8 -1.0 0.0 -3.8 -3.2 -0.1 -1.0 -1.2 0.3 0.9 -0.9 2.0 -0.4
Medication: Blood pressure 0.3 0.5 1.2 -0.1 -0.8 0.0 0.2 1.0 -1.1 -0.1 1.0 -0.3 -0.9 0.5 -1.1 -0.3
Angina (self-reported) 0.9 1.2 4.5 -0.0 -1.4 0.0 -1.8 -0.5 -2.1 -1.7 0.6 -0.2 -1.2 -0.1 -0.9 -0.5
Migraine (self-reported) 1.8 2.2 5.5 -1.5 0.1 0.0 -0.7 -1.4 -1.6 -2.1 1.3 -2.1 -1.2 -2.0 -0.9 -2.3
Medication: Ibuprofen 1.3 1.6 4.2 -1.6 0.8 0.0 -0.9 -1.1 -1.8 0.4 2.0 -0.2 -2.1 -0.7 -1.2 -0.9
Medication: Allopurinol 1.0 1.4 3.1 1.8 -1.8 0.0 0.7 0.4 1.3 0.2 -1.8 0.5 1.5 0.8 1.0 1.3
Medication: Omeprazole 0.6 0.7 1.6 -0.9 0.2 0.0 -0.9 0.5 -1.0 -1.3 0.8 -0.7 -1.0 -0.9 -0.7 -1.2
Medication: Seretide 50 evohaler 0.4 0.4 1.9 0.5 -0.8 0.0 -1.2 -1.4 -0.4 -0.3 -0.4 0.5 0.5 0.2 0.7 -0.2
Mean time to correctly identify matches 0.3 0.6 2.0 0.4 -0.2 0.0 -0.3 -0.1 1.4 -0.1 -1.0 -1.2 1.3 -0.6 0.8 -0.1
Heart disease (mother) 0.6 0.7 3.4 0.6 0.1 0.0 0.4 1.9 1.0 1.3 -0.8 0.5 0.4 0.7 0.4 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.6 0.1 0.0 0.0 0.1 -0.6 0.4 -0.4 -0.5 0.8 0.4 -0.1 0.3 0.3
Whole body fat mass 0.6 2.5 5.4 -1.8 -0.4 0.0 0.6 -0.6 -2.0 -2.3 1.6 -1.8 -1.5 -1.7 -1.8 -2.0
Leg fat mass (right) 1.0 3.9 7.2 -2.4 -0.3 0.0 0.4 -0.7 -2.7 -2.6 2.3 -2.0 -2.1 -2.1 -2.4 -2.5
Arm predicted mass (right) 0.4 1.9 4.2 -1.3 -1.0 0.0 0.5 -0.6 -2.0 -2.1 1.5 -1.3 -1.5 -1.2 -1.8 -1.5
Pulse rate, automated reading 0.3 0.8 2.6 -1.1 1.1 0.0 0.1 0.2 -0.8 0.9 1.4 -0.4 -1.6 0.4 -1.4 0.1
Alcohol intake frequency. 0.2 0.4 1.1 0.6 -0.8 0.0 -0.5 -0.7 0.4 -1.1 -0.9 -0.0 0.6 -0.3 0.9 -0.4
Comparative height size at age 10 0.4 2.2 4.3 -1.9 0.3 0.0 1.7 -0.1 -1.0 -1.5 1.6 -2.0 -1.7 -1.6 -2.1 -1.7
Number of full sisters 0.7 0.8 4.0 0.0 1.3 0.0 0.5 0.1 0.7 2.0 -0.2 1.6 0.1 0.9 0.3 1.0
Suffer from ‘nerves’ 0.1 0.2 0.6 -0.3 0.7 0.0 0.6 -0.1 0.4 0.8 0.3 0.4 -0.2 -0.0 -0.2 0.3
Overall health rating 0.3 0.7 3.2 -1.3 1.8 0.0 -0.4 -0.1 -0.0 0.6 1.2 -0.4 -1.0 -0.7 -0.5 -0.5
Chest pain or discomfort 0.2 0.4 0.9 -0.7 0.7 0.0 -0.8 -0.9 -0.5 0.8 0.6 -0.2 -0.6 -0.0 -0.5 0.1
Had major operations 0.2 0.3 1.7 0.1 -0.2 0.0 1.3 -0.1 0.9 0.3 -0.6 -0.4 0.5 0.0 0.1 0.3
Age at last live birth 0.6 0.8 3.1 -1.1 1.8 0.0 1.0 1.1 0.1 0.8 1.3 0.2 -0.9 0.1 -0.9 0.0
Family relationship satisfaction 0.3 0.4 1.7 -0.8 0.9 0.0 -0.3 -1.3 -0.1 -0.2 0.5 -0.1 -0.3 -0.7 0.1 -0.7
Leg pain on walking 0.6 0.7 3.4 -0.3 -0.5 0.0 -1.9 -1.4 -0.6 -1.0 -0.2 -0.5 -0.2 -0.9 0.4 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 4.5 -1.2 2.1 0.0 1.2 1.6 0.3 0.4 0.7 -1.3 -0.6 -0.8 -0.8 -0.4
Commuting to job workplace: Car/motor vehicle 0.5 0.6 2.7 -0.6 1.4 0.0 0.4 0.6 1.3 1.6 0.2 0.3 0.1 -0.0 0.1 0.1
Illness, injury, bereavement, stress in last 2 years 2.0 2.4 4.7 2.1 -0.8 0.0 0.3 0.4 1.9 1.3 -1.9 1.8 2.2 1.7 2.1 1.5
Medication: Aspirin 0.6 0.7 2.0 -1.0 -0.2 0.0 0.1 -0.5 -0.9 -0.5 1.2 -1.2 -1.3 -0.3 -1.4 -0.7
Supplements: Vitamin C 0.8 1.0 3.9 0.8 -1.4 0.0 -2.0 -1.9 -0.9 -0.8 -0.5 0.2 0.1 0.4 0.5 0.1
Knee pain experienced in last month 0.9 1.4 5.0 1.2 -0.5 0.0 -1.9 -0.3 1.4 0.2 -1.8 0.7 1.7 -0.0 2.2 0.4
Hypertension (Self-reported) 0.4 1.0 2.6 -1.3 0.4 0.0 0.9 0.6 -0.4 -0.7 1.3 -1.6 -0.9 -1.0 -1.4 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.0 -0.7 -0.1 0.0 0.3 0.1 -0.5 -0.7 0.7 -0.5 -0.8 -0.6 -1.0 -0.2
Illnesses of father: Heart disease 1.7 2.4 7.2 -1.4 0.6 0.0 2.1 2.0 -1.4 0.7 2.1 -0.7 -2.3 0.4 -2.7 -0.4
Illnesses of siblings: Diabetes 0.2 0.2 1.2 0.1 -0.4 0.0 0.5 0.0 -0.4 -1.1 -0.1 -0.6 0.1 -0.3 -0.2 -0.6
Smoking status: Previous 0.5 0.8 4.0 -1.1 0.7 0.0 -0.1 -2.0 0.4 0.2 0.5 -1.3 -0.3 -1.0 -0.5 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.8 0.4 -0.6 0.0 0.9 -0.4 0.5 -0.4 -0.6 -0.2 0.6 -0.1 0.1 0.4
Whole body fat-free mass 0.3 1.7 4.2 -1.0 -1.5 0.0 1.0 -0.2 -1.9 -2.1 1.3 -1.4 -1.3 -0.9 -1.8 -1.3
Leg fat-free mass (right) 0.2 1.3 4.1 -0.3 -2.0 0.0 1.1 0.4 -1.7 -1.9 0.7 -0.8 -0.8 -0.3 -1.3 -0.7
Arm fat percentage (left) 0.3 1.3 3.8 -1.0 -0.8 0.0 0.8 0.1 -1.8 -1.9 1.2 -0.9 -1.0 -0.7 -1.5 -1.1
Average weekly red wine intake 1.0 1.5 3.4 1.8 -1.7 0.0 -0.4 1.0 0.2 0.3 -1.4 1.7 1.1 1.8 1.0 1.3
Handedness (chirality/laterality): Left-handed 0.6 0.7 3.4 -0.8 1.8 0.0 0.4 0.7 1.2 1.5 0.1 0.3 -0.3 -0.6 -0.1 0.3
Mood swings 0.8 1.5 4.2 -2.0 1.7 0.0 0.6 -0.7 -0.4 -0.0 1.5 -1.0 -1.3 -1.6 -1.1 -1.6
Loneliness, isolation 0.5 0.7 1.6 -1.3 0.8 0.0 0.5 -0.6 -0.7 0.0 1.0 -0.8 -1.2 -0.7 -1.1 -0.8
Long-standing illness, disability or infirmity 0.2 0.3 1.6 0.1 -0.5 0.0 -1.3 -1.1 -0.8 -0.6 0.0 0.1 -0.1 -0.2 0.1 -0.3
Ever had bowel cancer screening 1.1 1.2 4.1 0.2 -0.8 0.0 -1.5 -1.5 -0.0 -2.0 -0.7 -1.4 0.5 -1.4 0.7 -1.2
Diabetes diagnosed by doctor 0.3 0.5 1.9 -0.9 0.1 0.0 -0.3 0.1 -1.0 -0.9 0.7 -0.4 -0.9 -0.8 -0.4 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 6.4 -0.4 2.5 0.0 1.0 0.9 2.3 1.9 -0.3 0.3 1.0 -0.0 0.7 1.0
Friendships satisfaction 0.3 0.3 0.7 -0.8 0.6 0.0 0.1 -0.2 -0.3 -0.6 0.7 -0.7 -0.6 -0.8 -0.4 -0.8
Qualifications: nursing, teaching 0.4 0.7 1.9 1.0 -1.1 0.0 -0.2 -1.4 0.5 -0.1 -1.1 0.8 0.9 0.3 1.2 0.4
Commuting to job workplace: Walk 0.5 0.5 2.5 0.1 -0.5 0.0 -0.5 -0.9 -0.6 -1.6 0.2 -1.2 -0.4 -0.6 -0.5 -0.1
Eye problems/disorders: Cataract 0.2 0.2 1.0 -0.5 0.3 0.0 0.6 -1.0 -0.1 0.2 0.6 -0.6 -0.5 -0.2 -0.6 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.0 1.7 4.4 2.1 -1.0 0.0 -0.4 0.3 0.5 1.0 -1.7 1.7 1.3 1.6 1.6 1.6
Medication for cholesterol 0.1 0.1 0.5 0.2 -0.3 0.0 -0.1 -0.7 -0.4 -0.5 -0.2 -0.2 -0.1 0.1 -0.2 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 2.0 -0.2 0.6 0.0 1.4 1.3 1.0 -0.2 -0.1 -1.0 0.0 -0.1 -0.7 0.7
Back pain experienced in last month 0.8 1.2 2.3 -1.4 0.4 0.0 -0.7 -1.0 -1.4 -1.1 1.3 -0.8 -1.4 -1.3 -1.0 -1.5
Mineral and other dietary supplements 0.3 0.4 1.3 0.0 0.7 0.0 1.0 0.9 1.1 0.8 -0.2 -0.4 0.4 -0.1 0.2 0.2
Breast cancer (self-reported) 0.5 0.6 1.7 -0.4 -0.4 0.0 -0.1 -0.9 -1.3 -1.1 0.8 -1.0 -0.8 -0.4 -1.1 -0.7
Asthma (self-reported) 0.2 0.5 2.4 -0.1 -0.4 0.0 -0.7 -1.0 -1.5 0.3 0.8 0.3 -0.9 0.5 -0.7 0.1
Osteoporosis (self-reported) 1.0 1.2 3.2 1.5 -1.0 0.0 0.2 -0.7 0.4 0.9 -1.0 1.7 0.9 1.8 0.9 1.5
Osteoarthritis (self-reported) 0.6 0.8 2.8 1.2 -1.7 0.0 -0.9 -1.2 -0.2 0.2 -0.9 0.7 0.7 0.9 0.6 1.0
Medication: Aspirin 0.6 0.7 1.8 -0.7 -0.7 0.0 0.1 -0.5 -1.1 -1.0 0.9 -1.3 -1.1 -0.3 -1.3 -0.7
Medication: Gliclazide 0.1 0.1 0.3 -0.0 0.5 0.0 -0.4 -0.1 0.3 0.1 -0.2 -0.1 0.3 -0.4 0.5 -0.3
Illnesses of father: None of the above (group 1) 0.5 0.6 3.5 -0.2 -0.1 0.0 -1.9 -1.9 -0.8 -0.3 0.3 -0.3 -0.3 -0.3 0.0 -0.4
Smoking status: Current 0.5 0.9 2.5 0.3 -0.8 0.0 -1.6 -1.2 -0.0 -1.4 -0.8 0.1 0.8 -1.1 1.3 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.6 3.9 -1.6 1.3 0.0 0.2 0.5 -0.7 0.5 1.9 -1.9 -1.7 -0.8 -2.0 -1.0
Whole body water mass 0.3 1.7 4.0 -0.9 -1.5 0.0 1.0 -0.0 -1.8 -2.0 1.2 -1.4 -1.2 -0.8 -1.8 -1.2
Leg predicted mass (right) 0.2 1.2 4.2 -0.2 -2.1 0.0 1.2 0.4 -1.6 -1.9 0.6 -0.8 -0.7 -0.2 -1.3 -0.6
Arm fat mass (left) 0.4 1.5 4.3 -1.1 -0.9 0.0 0.8 -0.2 -1.8 -2.1 1.1 -1.2 -1.0 -1.1 -1.5 -1.4
Number of self-reported non-cancer illnesses 0.2 0.4 1.6 -0.1 -0.7 0.0 -0.9 -1.3 -0.3 -0.4 0.2 -1.1 -0.1 -0.7 -0.1 -0.8
Average weekly champagne plus white wine intake 1.3 1.7 4.1 2.0 -1.4 0.0 0.5 -0.0 0.9 0.8 -1.8 1.0 1.8 1.6 1.4 1.7
Miserableness 0.3 0.6 2.1 -1.1 0.9 0.0 0.1 -0.9 0.3 -0.2 0.6 -1.0 -0.6 -1.5 -0.3 -0.8
Guilty feelings 0.4 0.6 2.6 0.3 0.5 0.0 0.6 0.6 1.6 1.4 -0.8 -0.1 0.8 0.2 0.8 0.4
Wears glasses or contact lenses 0.4 0.5 1.0 -0.7 -0.5 0.0 0.6 0.3 -1.0 -0.6 0.8 -0.6 -0.8 -0.6 -1.0 -0.8
Ever taken oral contraceptive pill 1.6 1.8 3.6 -1.7 0.8 0.0 -0.3 -0.7 -1.9 -1.1 1.6 -1.3 -1.9 -1.5 -1.8 -1.0
Hearing aid user 1.1 1.3 5.6 -0.2 2.4 0.0 -0.3 0.3 2.1 2.0 -0.4 -0.2 0.8 -0.2 1.0 0.7
Mother’s age at death 1.8 2.3 4.7 -2.0 1.1 0.0 0.3 -1.6 -1.5 -1.2 2.2 -1.0 -2.1 -1.5 -2.0 -1.5
Financial situation satisfaction 0.1 0.2 0.9 0.3 -0.9 0.0 0.7 0.3 0.0 -0.4 -0.2 -0.3 -0.1 -0.0 -0.4 0.5
Tinnitus: Yes, now most or all of the time 1.3 1.5 6.5 -1.6 0.4 0.0 1.0 -0.8 0.0 -1.1 0.6 -2.5 -0.6 -1.8 -1.3 -1.3
Commuting to job workplace: Public transport 1.1 1.3 5.4 1.0 -2.3 0.0 -0.8 -1.4 -1.5 -2.3 -0.4 -0.1 0.1 0.0 0.1 -0.2
Eye problems/disorders: Glaucoma 0.6 0.7 1.9 0.5 -0.1 0.0 1.3 0.6 1.0 1.4 -0.3 0.1 0.6 1.3 -0.1 1.3
Medication: Blood pressure 0.2 0.4 1.6 -0.2 0.4 0.0 1.0 1.2 1.2 0.3 -0.3 -0.1 0.7 -0.3 0.4 -0.2
Pain type(s) experienced in last month: Hip pain 0.9 1.1 5.1 -1.3 1.1 0.0 -0.9 -0.5 0.4 -0.9 0.4 -1.5 -0.1 -2.2 -0.0 -1.6
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.2 0.2 -0.8 0.0 -1.5 -0.7 -1.2 -0.6 -0.0 0.8 -0.4 0.2 0.3 -0.2
High cholesterol (Self-reported) 0.1 0.2 0.6 -0.5 0.4 0.0 0.7 -0.5 -0.1 0.8 0.8 0.3 -0.6 0.0 -0.5 -0.3
Medication: Bendroflumethiazide 0.4 0.6 3.2 -0.2 -0.6 0.0 1.7 1.8 -0.4 -0.2 0.5 -0.5 -0.4 0.4 -1.1 -0.1
Medication: Paracetamol 0.5 0.8 3.0 -0.5 -0.6 0.0 -0.6 -1.7 -0.5 -0.9 0.2 -1.7 -0.5 -0.9 -0.4 -0.9
Medication: Lisinopril 0.4 0.5 1.9 0.9 -1.1 0.0 1.4 1.0 0.2 0.1 -0.5 0.2 0.6 1.1 0.1 0.2
Medication: Atorvastatin 0.7 0.9 3.7 -0.9 0.9 0.0 0.4 0.1 -0.4 1.9 1.5 0.7 -1.1 0.8 -1.1 0.3
Illnesses of father: High blood pressure 0.3 0.3 1.4 0.4 -0.9 0.0 1.2 0.8 0.3 -0.7 -0.4 -0.3 0.5 -0.1 0.1 -0.4
Alcohol drinker status: Never 3.2 3.8 7.1 1.5 0.9 0.0 2.6 2.5 2.0 2.7 -1.3 2.0 1.6 2.5 0.8 2.6
Ever smoked 0.2 0.4 3.5 -0.3 -0.3 0.0 -0.2 -1.9 0.7 -0.2 -0.6 -0.3 0.6 -0.7 0.3 -0.1
Basal metabolic rate 0.3 1.8 4.3 -1.0 -1.5 0.0 0.9 -0.2 -1.9 -2.1 1.3 -1.5 -1.3 -0.9 -1.8 -1.3
Leg fat percentage (left) 1.0 3.6 7.1 -2.7 0.7 0.0 0.3 -0.6 -2.1 -2.0 2.3 -2.1 -2.1 -2.4 -2.2 -2.5
Arm fat-free mass (left) 0.5 2.5 4.6 -1.7 -0.9 0.0 0.5 -0.6 -2.1 -2.1 1.7 -1.8 -1.8 -1.7 -2.0 -1.9
Number of operations (self-reported) 0.1 0.1 0.3 -0.6 0.1 0.0 -0.4 -0.6 -0.0 0.3 0.2 -0.2 -0.2 -0.5 0.2 -0.4
Average weekly beer plus cider intake 1.5 2.2 4.5 -2.1 1.4 0.0 -1.4 -0.9 -1.6 -0.8 2.0 -1.2 -1.8 -1.6 -1.1 -2.0
Irritability 0.2 0.3 1.5 -0.6 0.7 0.0 1.2 0.4 -0.3 0.2 0.7 0.3 -0.4 0.3 -0.6 0.1
Risk taking 0.7 1.0 4.2 -0.6 0.2 0.0 -1.3 -2.1 0.0 -1.0 -0.3 -0.7 0.3 -1.5 0.7 -1.4
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 0.3 -0.4 0.0 0.1 -0.2 0.3 0.5 -0.1 -0.6 0.1 0.3 -0.1 0.1
Fractured/broken bones in last 5 years 0.5 0.7 2.1 -0.3 0.4 0.0 -1.3 -1.5 0.4 -0.3 -0.6 0.3 0.7 -1.1 1.3 -0.8
Age started oral contraceptive pill 0.3 0.3 1.2 0.1 1.0 0.0 -1.1 -1.1 -0.1 0.1 -0.3 0.6 0.3 0.1 0.6 -0.1
Diastolic blood pressure, automated reading 0.7 2.2 6.7 -1.6 1.0 0.0 1.1 1.1 -2.0 0.7 2.4 -0.5 -2.2 0.3 -2.6 -0.4
Ever depressed for a whole week 0.4 0.4 1.1 -0.0 -0.7 0.0 -0.2 -0.9 0.5 -1.1 -0.6 -1.0 0.7 -0.8 0.5 -0.6
Unable to work because of sickness or disability 0.4 0.5 2.2 -0.5 0.9 0.0 0.3 -0.6 1.2 -0.5 -0.5 -0.8 0.2 -1.5 0.2 -0.3
Commuting to job workplace: Cycle 1.0 1.3 3.9 1.1 0.5 0.0 -0.7 0.5 1.0 2.0 -0.7 1.6 0.7 1.3 0.9 1.8
Myopia 1.6 2.3 7.3 -1.1 2.7 0.0 2.3 2.1 0.2 2.2 1.2 0.4 -1.0 0.9 -1.5 0.9
Vascular/heart problems diagnosed by doctor 0.5 1.4 2.8 1.6 -0.5 0.0 0.2 0.1 1.0 0.9 -1.7 1.6 1.3 1.2 1.4 1.6
Cholesterol lowering medication 0.3 0.4 2.7 -0.1 0.6 0.0 1.6 0.8 0.7 1.0 -0.1 -0.4 0.2 0.4 -0.3 0.3
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 2.1 -1.3 1.0 0.0 -0.0 1.0 -1.0 -0.6 1.2 -0.8 -1.5 -0.6 -1.4 -0.7
Pain experienced in last month 1.5 2.6 7.5 -1.2 0.2 0.0 2.7 2.0 -1.9 -0.1 2.2 -0.1 -2.1 0.7 -2.7 -0.2
Supplements: Calcium 2.2 2.4 5.4 2.3 -2.1 0.0 -0.9 -1.8 0.5 0.3 -1.9 1.4 1.6 1.8 1.6 1.7
Basal cell carcinoma (self-reported) 0.3 0.4 1.3 -0.8 1.1 0.0 -0.5 0.4 -0.3 0.6 0.7 -0.7 -0.9 -0.5 -0.6 -0.2
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.6 -0.6 0.5 0.0 -0.4 0.7 -0.3 -0.7 0.4 -0.8 -0.3 -0.8 -0.5 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 4.0 -0.8 0.2 0.0 -2.0 -0.9 -0.1 -1.4 0.2 -0.2 -0.1 -1.5 0.7 -1.3
Heart disease (siblings) 0.1 0.1 0.9 0.1 -0.6 0.0 -0.5 -0.9 -0.1 -0.3 -0.1 -0.4 -0.0 -0.2 -0.0 -0.1
Alcohol drinker status: Previous 0.9 1.1 5.4 -0.1 -0.9 0.0 -0.7 -2.3 -0.0 -1.5 -0.4 -0.9 0.2 -1.4 0.5 -1.2
Pack years of smoking 0.9 1.3 4.0 -1.5 0.8 0.0 -1.0 -1.5 -0.3 -1.6 0.7 -1.0 -0.6 -2.0 -0.1 -1.4
Impedance of whole body 0.1 0.7 4.0 -0.8 2.0 0.0 -1.0 -0.9 0.8 0.8 0.2 -0.3 -0.2 -0.9 0.5 -0.5
Leg fat mass (left) 1.1 4.1 7.6 -2.4 -0.4 0.0 0.5 -0.7 -2.7 -2.8 2.3 -2.2 -2.2 -2.2 -2.4 -2.5
Arm predicted mass (left) 0.5 2.6 6.2 -1.5 -1.1 0.0 0.5 -0.6 -2.1 -2.5 1.5 -1.8 -1.6 -1.7 -1.9 -2.0