TWAS hub - WDR45B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.199	0.0620	0.00037	0.054	NA	0.114	NA	0.110	0.00003	NA	1.5e-09	NA	2.7e-09
2	GTEx	Brain Cortex	0.209	0.0820	0.00370	-0.011	NA	-0.005	NA	-0.011	0.92000	NA	4.8e-01	NA	9.4e-01
3	GTEx	Nerve Tibial	0.138	0.0612	0.00071	0.028	NA	0.060	NA	0.042	0.00420	NA	4.4e-05	NA	6.1e-04
4	GTEx	Skin Sun Exposed Lower leg	0.145	0.0530	0.00064	0.000	NA	0.033	NA	0.030	0.32000	NA	9.6e-04	NA	1.6e-03
5	GTEx	Testis	0.171	0.0680	0.00800	0.023	NA	0.058	NA	0.031	0.03300	NA	1.4e-03	NA	1.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
HbA1C	8.6	9.6	14.7	2.9	2.9	3.8	1.9	3.5
Medication: Omeprazole	5.6	6.7	9.3	1.9	2.3	3.0	2.5	3.0
Medication: Omeprazole (e.g. Zanprol)	4.8	5.8	7.7	2.2	2.0	2.6	2.4	2.8
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	7.1	2.0	0.3	2.7	1.8	-1.2
Diabetes (mother)	2.7	3.4	6.6	-1.0	-1.0	-2.0	-2.6	-2.1
Medication: Lansoprazole	2.7	3.0	5.5	1.4	1.1	2.4	2.3	1.1
Breast Cancer	2.5	5.9	24.2	4.9	0.3	1.6	1.6	0.5
Fractured/broken bones in last 5 years	2.5	3.2	5.1	2.1	0.4	2.1	2.2	1.5
Medication: Allopurinol	2.2	2.9	6.6	-1.6	-2.6	-1.5	-1.8	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	4.9	1.0	0.6	1.4	2.2	2.2
Average weekly spirits intake	2.1	2.6	10.1	-0.3	-0.3	-0.4	-1.6	-3.2
Alzheimer’s Disease (including proxy)	2.0	2.9	6.3	-2.5	-0.7	-2.5	0.1	-1.3
Loud music exposure frequency	2.0	2.1	6.4	2.5	0.9	1.7	0.6	0.6
Alzheimer’s Disease (in father)	1.9	2.1	6.6	-2.6	0.2	-1.5	-0.0	-1.2
Major Depression (MDD)	1.9	2.3	5.9	1.1	2.4	1.1	1.0	1.5
Breast cancer (self-reported)	1.9	2.3	5.4	0.4	0.7	2.3	1.4	1.9
Age started oral contraceptive pill	1.9	2.4	9.9	1.2	-0.4	-0.0	-0.5	3.1
Medication: Co-codamol	1.8	2.1	7.5	1.3	-0.5	1.0	0.3	2.7
Alcohol intake versus 10 years previously	1.8	2.6	8.6	1.2	-0.0	1.6	0.7	2.9
Heart disease (siblings)	1.8	2.2	3.8	-1.0	-1.5	-1.8	-2.0	0.5
Heart attack	1.7	2.1	5.1	-1.2	-0.1	-2.2	-2.0	-0.3
Impedance of arm (left)	1.7	7.9	28.2	2.3	5.3	2.0	1.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.3	3.7	1.2	1.0	1.9	1.3	1.9
Supplements: Vitamin C	1.7	2.0	5.8	0.4	2.4	0.9	0.8	1.7
Heart attack/myocardial infarction (self-reported)	1.7	2.2	5.2	-1.2	-0.3	-2.3	-2.1	-0.4
Number of live births	1.6	2.2	3.0	1.6	0.7	1.7	1.7	1.4
Pack years of smoking	1.6	2.3	3.7	-1.6	-1.5	-1.8	-1.9	-0.2
Pack years adult smoking proportion	1.5	2.2	3.3	-1.6	-1.4	-1.8	-1.8	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	5.3	0.8	0.7	1.8	1.1	2.3
Medication: Aspirin	1.5	2.0	4.2	-1.0	-1.1	-1.3	-2.0	1.3
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	3.2	-1.4	-1.8	-1.4	-1.8	-1.2
Stomach or abdominal pain in last month	1.4	1.7	5.3	0.3	2.3	0.9	0.9	1.3
Had other major operations	1.4	1.7	5.0	1.0	0.4	2.2	1.4	0.3
Number of children fathered	1.4	1.6	5.7	-1.3	-0.4	-0.6	0.5	-2.4
Eye problems/disorders: Cataract	1.4	1.7	4.7	-1.3	-2.2	-0.6	-1.1	-0.5
Impedance of whole body	1.4	7.2	27.9	1.6	5.3	1.7	1.2	-1.1
Supplements: Zinc	1.3	1.4	3.0	1.3	1.7	0.3	0.2	1.5
Maternal smoking around birth	1.3	1.8	3.3	-1.6	0.1	-1.8	-0.5	-1.7
Taking other prescription medications	1.3	1.9	4.4	-1.7	-0.3	-0.9	-2.1	1.2
Impedance of arm (right)	1.3	6.1	22.0	2.0	4.7	1.9	1.0	-0.5
Happiness	1.3	1.6	3.4	-1.9	0.3	-1.2	-0.4	-1.7
High blood pressure (siblings)	1.3	1.9	5.5	1.0	0.3	1.2	1.2	2.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.5	0.3	1.5	1.2	1.9	0.4
Heart disease (mother)	1.3	1.6	3.3	1.6	1.2	1.8	0.9	0.3
Illnesses of father: Heart disease	1.3	1.8	7.3	0.6	2.7	1.0	0.0	0.3
Ulcerative Colitis (UC)	1.2	2.3	7.2	-0.9	-0.3	-1.7	-2.7	-0.5
Age when periods started (menarche)	1.2	2.9	9.2	3.0	0.1	1.9	1.2	0.5
Number of full brothers	1.2	1.5	3.0	1.3	0.7	1.4	0.4	1.7
Illnesses of siblings: Diabetes	1.2	1.5	2.9	1.7	0.2	1.4	1.5	0.5
Ever had bowel cancer screening	1.2	1.4	3.9	2.0	-0.0	0.6	1.6	0.3
Medication: Aspirin	1.2	1.5	3.3	-0.9	-1.0	-1.1	-1.8	1.2
Hearing aid user	1.2	1.3	6.5	0.1	0.4	0.2	-0.1	2.5
Alzheimer’s Disease (in mother)	1.1	1.3	3.2	-1.2	-0.8	-1.8	0.0	-1.1
Verbal and Numeric Reasoning (VNR)	1.1	2.6	6.6	2.6	-0.3	0.8	0.9	2.3
Schizophrenia (2014)	1.1	2.4	8.1	-2.8	1.6	0.7	0.8	0.2
Triglycerides	1.1	1.8	3.3	-1.8	-1.8	-1.2	-1.0	0.2
Body mass index (BMI)	1.1	4.5	20.1	0.7	-4.5	-0.2	0.2	1.3
Nervous feelings	1.1	2.0	4.7	0.4	2.2	2.1	0.4	0.9
Commuting to job workplace: Walk	1.1	1.2	2.5	-0.6	-1.4	-0.8	-1.6	-0.8
Bipolar Disorder or Schizophrenia	1.0	2.5	6.5	-1.0	2.5	1.6	1.4	0.9
Depression (Nagel 2018)	1.0	1.5	4.8	-2.2	-0.1	-0.4	-1.5	-0.5
HDL Cholesterol	1.0	1.7	3.4	1.8	0.7	1.5	1.1	1.1
Blood Platelet Count	1.0	11.5	26.6	1.6	1.1	5.2	2.8	4.4
Smoking Status	1.0	2.4	6.6	1.2	-2.6	0.6	-0.2	1.9
Hypothyroidism (self reported)	1.0	2.4	6.7	-1.5	-0.5	-1.6	-2.6	0.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	3.9	0.2	-0.9	-0.6	0.7	-2.0
Waist circumference	1.0	3.5	15.4	1.1	-3.9	0.2	0.3	1.0
Number of incorrect matches in round	1.0	1.7	2.5	-1.0	1.1	1.2	1.6	1.5
Past tobacco smoking	1.0	1.9	7.1	0.3	2.7	0.0	-0.6	-1.3
Depression (self-reported)	1.0	1.2	4.9	-0.8	2.2	0.5	-0.2	0.6
Gout (self-reported)	1.0	1.3	3.2	-0.5	-1.8	-1.2	-1.3	0.1
Leg fat percentage (right)	1.0	3.5	15.3	1.0	-3.9	0.1	0.3	1.0
Mean time to correctly identify matches	1.0	2.0	3.3	1.6	1.8	1.2	0.4	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.9	1.1	-0.6	1.4	1.4	-0.9
Family relationship satisfaction	1.0	1.3	4.6	-0.7	0.9	-0.6	0.1	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	3.6	1.9	1.6	1.6	0.9	0.6
Medication: Atorvastatin	1.0	1.2	2.7	1.6	1.4	0.4	0.8	0.7
Alcohol drinker status: Previous	1.0	1.1	2.1	0.8	-1.2	-1.5	-1.0	0.6
Schizophrenia (2018)	0.9	1.8	3.0	-0.8	1.5	1.4	1.7	1.1
Reaction Time	0.9	1.8	3.6	1.1	1.9	1.1	1.1	1.2
Body Mass Index (BMI) (2010)	0.9	1.2	4.0	-0.5	-2.0	0.1	0.9	1.1
Crohns Disease (2012)	0.9	1.5	2.8	1.0	1.7	1.0	1.5	-0.4
BMI	0.9	5.4	24.5	0.4	-5.0	-0.2	0.2	1.6
Severe depression (siblings)	0.9	1.0	2.1	1.0	1.5	1.1	0.4	0.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.5	0.9	1.2	1.1	0.8	0.9
Medication: Atenolol	0.9	1.1	2.2	1.5	0.9	1.5	0.6	-0.2
Time employed in main current job	0.9	1.0	2.6	0.7	-0.6	-1.3	-1.6	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.1	0.1	0.7	1.8	1.0	1.6
Hair/balding pattern: Pattern 3	0.9	1.3	2.8	1.7	-1.6	0.4	-0.1	-1.0
Hair/balding pattern: Pattern 4	0.9	2.1	4.0	-1.6	0.3	-2.0	-2.0	-0.1
Medication: Paracetamol	0.9	1.5	3.4	1.0	0.6	1.6	1.9	-0.4
Glaucoma (self-reported)	0.9	1.0	1.8	0.4	1.3	0.5	1.3	1.1
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	5.6	-1.3	-0.2	-1.1	-2.4	0.1
Health satisfaction	0.9	1.2	3.6	-1.9	-0.9	-0.7	-0.6	-0.8
Medication: Ibuprofen	0.9	1.0	5.2	0.0	-2.3	-0.1	-0.0	0.2
Leg fat mass (right)	0.9	3.6	14.4	1.2	-3.8	0.7	0.5	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.9	-1.3	0.2	1.0	0.8	-1.4
Average weekly red wine intake	0.9	1.4	2.4	0.2	-1.5	-1.2	-1.4	1.1
Leg fat percentage (left)	0.9	3.2	14.6	0.8	-3.8	-0.3	0.1	0.7
Unable to work because of sickness or disability	0.9	1.2	2.0	-1.4	1.4	-0.2	-1.1	0.8
Prostate Cancer	0.8	1.1	2.2	-0.1	1.5	-1.4	0.5	-1.0
LDL Cholesterol	0.8	1.2	2.7	-0.3	-1.6	1.0	0.8	-1.3
Chronotype (morning person)	0.8	1.9	4.1	2.0	0.6	1.5	0.6	1.6
Hearing difficulty/problems: Yes	0.8	1.3	3.3	-1.8	0.4	-1.2	-1.2	-0.2
Medication: Levothyroxine sodium	0.8	1.3	4.2	-1.3	-0.0	-0.6	-2.1	0.4
Worrier / anxious feelings	0.8	1.5	3.8	0.6	-0.0	2.0	1.1	1.4
Arm fat mass (right)	0.8	3.2	12.6	1.2	-3.5	0.1	0.1	1.3
Pulse wave reflection index	0.8	1.0	1.7	-0.4	-1.3	-1.1	-1.3	-0.6
Number of full sisters	0.8	0.9	3.0	-1.1	1.7	0.3	-0.4	0.5
Had major operations	0.8	0.9	1.6	-0.7	1.3	0.2	1.2	-1.1
Osteoarthritis (self-reported)	0.8	1.0	2.0	1.3	-0.2	0.7	1.4	0.9
Medication: Gliclazide	0.8	0.9	2.7	-1.6	-0.7	0.3	-0.4	-1.0
Smoking status: Current	0.8	1.2	4.3	-0.5	-0.7	0.2	-1.0	2.1
Arm fat mass (left)	0.8	3.3	12.8	1.3	-3.6	0.2	0.2	1.3
Guilty feelings	0.8	1.2	2.3	0.8	-1.1	1.1	1.5	1.0
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	-0.0	0.4	-1.2	-1.1	-1.4
Eye problems/disorders: Glaucoma	0.8	1.0	3.0	-0.3	1.7	0.3	1.3	0.1
Medication: Bendroflumethiazide	0.8	1.2	2.6	-0.5	0.8	1.2	1.6	1.0
Ever smoked	0.8	1.3	3.6	-0.4	-1.6	-0.1	0.4	1.9
Diastolic blood pressure, automated reading	0.8	2.5	6.0	-1.9	-2.4	-0.3	-0.0	-1.7
Leg fat mass (left)	0.8	3.3	14.0	1.0	-3.7	0.4	0.4	1.0
Bipolar Disorder (2018)	0.7	1.1	4.5	-0.4	2.1	0.7	0.2	0.2
Hayfever, allergic rhinitis or eczema	0.7	1.6	7.7	-0.1	-0.5	0.2	-0.2	2.8
Sitting height	0.7	5.0	8.0	2.8	2.6	2.7	1.3	0.9
Chronic bronchitis/emphysema (father)	0.7	0.8	2.3	0.9	-0.5	-0.7	-0.5	-1.5
Medication: Ramipril	0.7	0.9	2.7	-0.3	-0.9	-0.2	-0.8	1.7
Fluid intelligence score	0.7	1.5	2.7	1.6	-0.5	0.9	1.1	1.7
Arm fat percentage (right)	0.7	2.8	11.5	1.1	-3.4	-0.1	-0.0	1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.9	0.3	-0.4	1.0	0.6	1.7
Medication: Amlodipine	0.7	1.0	2.4	0.6	1.1	1.5	0.6	0.9
Birth weight	0.7	1.5	4.2	-2.0	-0.2	-1.4	-1.0	0.1
Neck or shoulder pain in last month	0.7	1.0	1.8	0.9	0.5	1.3	1.4	0.8
Arm fat percentage (left)	0.7	2.6	10.1	1.3	-3.2	0.2	0.1	1.1
Friendships satisfaction	0.7	0.8	1.9	-1.0	0.2	-0.9	-0.5	-1.4
Medication for cholesterol	0.7	1.0	2.8	0.4	-1.7	-0.8	-1.1	-0.6
Osteoporosis (self-reported)	0.7	0.9	2.0	0.8	0.5	1.4	1.2	-0.4
Supplements: Calcium	0.7	0.8	2.9	0.1	1.7	0.2	0.3	1.0
Crohns Disease (2017)	0.6	1.4	2.6	0.8	1.0	1.6	1.5	-0.8
Mean Putamen Volume	0.6	0.6	1.8	0.9	-1.3	-0.4	-0.2	0.6
Allergy or Eczema	0.6	1.5	4.5	0.6	-1.2	-0.5	-1.1	2.1
Hand grip strength (left)	0.6	1.7	4.2	-0.8	-2.1	-0.7	-1.4	-1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.6	1.6	-0.7	-0.3	-0.2	0.6
Impedance of leg (right)	0.6	2.8	10.0	0.6	3.2	1.1	0.8	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.6	-1.9	-0.3	0.0	-0.1	-0.6
Serious illness, injury or assault to yourself	0.6	0.7	2.8	1.7	0.4	0.5	0.3	-0.3
High blood pressure (mother)	0.6	0.8	3.4	0.6	1.8	0.4	0.5	0.4
Impedance of leg (left)	0.6	2.9	10.9	0.2	3.3	0.5	0.4	-1.7
Hair/balding pattern: Pattern 2	0.6	0.7	2.4	-1.5	-0.6	-0.8	-0.5	-0.3
Had menopause	0.6	0.7	2.1	0.1	-0.0	-0.5	-1.2	1.5
Mouth/teeth dental problems	0.6	1.0	2.9	-0.0	1.7	0.6	1.2	-0.0
Diabetes (self-reported)	0.6	0.9	2.8	1.7	0.4	0.8	0.7	-0.6
Illnesses of siblings	0.6	0.9	3.7	-0.5	0.7	-0.1	-0.3	-1.9
Weight	0.6	3.0	8.4	1.6	-2.9	1.0	0.7	1.6
Hip circumference	0.6	2.4	8.7	1.3	-3.0	0.5	0.5	1.0
Father’s age at death	0.6	0.8	1.2	-1.1	0.4	-1.1	-0.8	1.0
Noisy workplace	0.6	0.7	2.0	-0.8	-0.3	-0.7	-0.6	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.5	0.1	-1.9	0.4	0.5	0.4
Forced vital capacity (FVC), Best measure	0.6	2.2	5.3	1.6	2.3	1.7	0.5	0.2
Shortness of breath walking on level ground	0.6	0.7	1.3	1.0	0.6	0.6	-1.1	0.8
Whole body fat mass	0.6	2.6	10.1	1.5	-3.2	0.3	0.3	0.8
Alcohol intake frequency.	0.6	1.4	3.6	1.9	0.1	0.5	0.5	1.7
Smoking status: Previous	0.6	0.9	2.8	0.4	-1.7	0.1	1.1	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-0.9	-1.1	-0.7	-0.8	-0.1
Wears glasses or contact lenses	0.6	0.7	1.6	-0.9	-0.7	-0.6	-1.3	-0.2
High cholesterol (Self-reported)	0.6	1.0	2.1	-1.2	1.5	0.0	-0.6	-1.1
Medication: Paracetamol	0.6	1.0	2.1	0.9	-0.4	1.0	1.4	-0.9
Medication: Lisinopril	0.6	0.8	1.9	-1.4	-0.4	-1.3	0.2	0.4
Alcohol drinker status: Never	0.6	0.8	1.9	-1.2	-1.4	-0.6	-0.0	-0.3
Average weekly beer plus cider intake	0.6	0.8	2.2	-0.5	-1.5	-0.6	-0.9	-0.7
Commuting to job workplace: Cycle	0.6	0.7	1.6	0.2	-1.0	0.9	1.3	0.1
Myopia	0.6	0.8	1.6	1.1	-1.2	-0.1	-0.9	0.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.8	-0.6	-0.8	-1.3	-0.5	-0.8
Worry (Nagel 2018)	0.5	1.0	1.7	-1.3	1.2	0.9	-0.4	0.9
Ovarian Cancer	0.5	0.6	1.1	-0.9	-0.6	-1.0	-0.9	0.0
Age at First Birth	0.5	0.8	2.1	-1.4	1.2	0.3	0.3	0.4
Lupus	0.5	0.7	2.9	-0.3	0.6	0.3	0.0	-1.7
Rheumatoid Arthritis	0.5	0.7	1.1	-0.9	-0.3	-1.0	-1.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.6	-0.0	-0.1	-0.0	-0.4	-1.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	1.1	0.3	1.2	0.5	0.0
Leg fat-free mass (left)	0.5	2.4	4.1	1.5	-1.9	1.2	0.9	2.0
Current tobacco smoking	0.5	0.8	3.6	0.0	0.3	0.4	-0.4	1.9
Qualifications: CSEs or equivalent	0.5	0.6	2.2	-0.1	0.3	1.5	0.8	0.4
High blood pressure	0.5	1.5	4.8	-0.9	0.4	1.0	0.6	2.2
Leg predicted mass (left)	0.5	2.5	4.1	1.4	-1.9	1.3	1.0	2.0
Trunk fat mass	0.5	2.0	5.3	1.7	-2.3	0.8	0.6	0.9
Financial difficulties in last 2 years	0.5	0.6	1.4	1.2	-0.2	1.0	0.8	-0.4
Allergy	0.5	1.3	5.3	0.1	0.4	-0.9	0.3	-2.3
Medication: Simvastatin	0.5	0.7	1.4	-1.2	0.6	1.1	-0.5	-0.6
Mouth/teeth dental problems: Dentures	0.5	0.8	1.8	1.3	-0.2	0.7	-0.4	1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.9	-0.3	-0.9	-0.5	-0.9	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.6	-0.3	-0.3	-0.6	-1.0	1.3
Pulse wave peak to peak time	0.5	0.6	1.6	0.3	1.3	0.9	-0.1	0.8
Eye problems/disorders: None of the above	0.5	0.6	1.2	-0.1	1.0	-0.9	-1.1	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.8	2.6	0.6	1.0	0.1	0.1	-1.6
Medication: Blood pressure	0.5	0.8	2.0	-0.4	-1.1	-0.7	-1.4	0.4
Suffer from ‘nerves’	0.5	0.8	2.4	-0.4	1.6	0.9	0.4	0.6
Mother’s age at death	0.5	0.6	1.8	0.8	-0.6	-0.0	0.2	1.4
Financial situation satisfaction	0.5	0.6	1.4	-0.7	-1.2	0.8	0.7	0.5
Medication: Blood pressure	0.5	1.0	3.0	-1.1	0.3	0.4	1.7	0.7
Illnesses of father: High blood pressure	0.5	0.6	2.2	0.5	0.7	-0.1	0.2	1.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.5	-0.8	1.2	0.3	0.7	-0.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.9	-1.4	-0.5	-0.4	-1.4	0.2
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.8	1.4	0.3	1.2	0.8	1.3
Coronary Artery Disease (CAD)	0.4	0.5	1.1	-0.7	-0.5	-0.6	-1.1	0.4
Neuroticism (2016)	0.4	0.6	1.4	-1.2	0.8	1.0	0.2	-0.4
Ulcerative Colitis	0.4	0.6	1.7	-0.5	-0.1	-0.5	-1.3	-0.7
Systolic Blood Pressure	0.4	1.9	5.6	-2.4	-0.7	-0.4	-1.7	-0.9
Hair Pigment	0.4	12.5	26.6	1.1	2.5	3.6	5.2	4.0
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.0	-0.8	1.0	0.9	0.2	-0.3
Medication for hormone replacement therapy	0.4	0.4	0.8	0.9	0.7	0.4	-0.3	0.8
Diabetes (father)	0.4	0.5	1.4	0.5	1.2	0.3	-0.9	0.0
Trunk fat percentage	0.4	1.4	3.4	1.8	-1.7	0.6	0.6	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.4	-0.9	0.3	-0.0	0.0	-1.2
Medication: Cholesterol lowering	0.4	0.6	2.5	-0.6	0.3	-0.0	-1.6	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.2	1.4	1.5	1.4	0.2	0.3
Standing height	0.4	4.3	9.1	2.0	3.0	2.6	1.3	0.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-1.0	-0.2	0.4	0.8	-0.8
Body fat percentage	0.4	1.8	6.8	1.3	-2.6	0.1	0.4	0.5
Qualifications: College or University degree	0.4	1.3	2.6	-0.9	-0.4	-1.6	-1.4	-0.9
Emphysema/chronic bronchitis	0.4	0.5	0.9	0.9	0.9	0.4	-0.3	0.8
Chest pain or discomfort	0.4	0.6	2.1	0.2	-0.1	1.4	-0.1	0.9
Leg pain on walking	0.4	0.4	1.7	0.4	0.5	1.3	0.1	-0.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.3	0.0	0.9	0.6	-1.1	0.9
Miserableness	0.4	0.7	2.0	-0.6	-1.4	0.8	0.1	0.6
Commuting to job workplace: Public transport	0.4	0.5	1.0	-0.7	-1.0	-0.0	-0.2	1.0
Arm fat-free mass (left)	0.4	2.1	7.8	0.3	-2.8	0.5	0.4	1.4
Number of operations (self-reported)	0.4	0.6	1.7	0.3	1.3	0.6	0.9	0.1
Risk taking	0.4	0.6	2.4	1.6	0.1	0.8	0.3	0.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.0	1.3	-0.1	-0.4	0.2	-1.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	0.2	-1.2	-0.2	0.4	0.9
Arm predicted mass (left)	0.4	2.1	7.1	0.6	-2.7	0.4	0.6	1.6
Fasting Glucose	0.3	0.3	0.8	0.4	-0.4	-0.9	-0.6	-0.2
Height	0.3	5.8	12.0	1.4	3.5	3.5	0.2	1.7
Cardiovascular Disease	0.3	1.1	5.1	-2.3	0.2	0.5	-0.2	0.2
Respiratory disease	0.3	0.6	1.4	-0.2	1.2	0.8	-0.8	0.5
Lung FEV1/FVC ratio	0.3	1.5	6.9	0.1	-2.6	-0.3	-0.6	0.7
Sensitivity / hurt feelings	0.3	0.4	0.8	-0.9	0.8	-0.0	-0.8	0.3
Systolic blood pressure, automated reading	0.3	0.9	1.8	-1.3	-1.4	0.4	-0.6	-0.6
Vitamin and mineral supplements	0.3	0.4	1.0	0.2	-1.0	-0.4	0.5	-0.9
Medication: Metformin	0.3	0.4	0.7	0.9	-0.7	0.9	0.4	0.2
Hand grip strength (right)	0.3	0.8	2.1	-0.8	-1.4	0.1	-0.8	-0.9
Fed-up feelings	0.3	0.6	1.4	-1.2	-0.7	-0.1	-0.9	0.1
Alcohol usually taken with meals	0.3	0.5	1.4	-0.4	-0.5	-1.2	-0.8	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.3	1.1	1.1	0.4	0.2
Hearing difficulty/problems with background noise	0.3	0.5	1.5	-1.2	0.9	-0.5	0.3	0.1
Forced vital capacity (FVC)	0.3	1.0	2.7	1.1	1.6	0.9	-0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.9	-1.1	0.0	-0.2	-0.1	-1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	-0.8	0.6	0.3	-0.0	0.8
Pain all over the body in last month	0.3	0.3	1.0	1.0	-0.2	0.5	0.0	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.9	-0.5	0.3	-0.4	0.9
Falls in the last year	0.3	0.4	0.9	-0.3	0.4	0.9	0.6	0.7
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.2	1.5	0.9	1.1	0.1	0.4
Asthma	0.3	0.5	1.8	0.7	0.5	1.4	-0.4	-0.0
Prospective memory result	0.3	0.4	0.6	0.3	-0.8	-0.5	-0.6	-0.7
Lung cancer (father)	0.3	0.3	1.1	1.0	0.0	-0.6	-0.1	-0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	-0.1	-1.0	-0.6	0.3	-0.7
Exposure to tobacco smoke at home	0.3	0.3	0.9	0.8	-0.9	-0.1	0.1	0.3
Breastfed as a baby	0.3	0.3	0.9	0.9	0.0	-0.1	0.0	0.9
Arm fat-free mass (right)	0.3	1.7	6.1	0.5	-2.5	0.8	0.6	1.0
Exposure to tobacco smoke outside home	0.3	0.4	1.2	0.7	-0.1	1.1	0.2	0.6
Comparative body size at age 10	0.3	0.7	2.4	0.6	-1.6	-0.4	-0.4	0.7
Medication: Seretide 50 evohaler	0.3	0.3	0.5	0.7	0.6	-0.1	-0.4	-0.7
Arm predicted mass (right)	0.3	1.6	6.2	0.2	-2.5	0.4	0.3	1.2
Overall health rating	0.3	0.7	1.4	-1.0	1.1	1.2	0.1	0.4
Age at last live birth	0.3	0.5	0.8	0.9	-0.1	0.7	0.6	0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.3	-0.0	0.5	-1.1	-0.5	-0.0
Knee pain experienced in last month	0.3	0.5	1.6	-0.5	0.8	1.3	0.0	-0.1
Hypertension (Self-reported)	0.3	0.8	2.6	-1.0	-0.2	0.6	0.3	1.6
Whole body fat-free mass	0.3	1.4	4.1	0.5	-2.0	0.7	0.5	1.5
Leg fat-free mass (right)	0.3	1.7	3.1	1.3	-1.6	0.9	0.7	1.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-1.0	-0.7	-0.2	-0.1	0.3
Mood swings	0.3	0.5	1.5	-0.4	-1.2	-0.2	-0.8	-0.5
Diabetes diagnosed by doctor	0.3	0.4	1.0	1.0	0.0	0.4	0.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	1.1	-0.6	0.0	0.4	0.1
Leg predicted mass (right)	0.3	1.7	3.0	1.3	-1.6	1.0	0.7	1.7
Ever taken oral contraceptive pill	0.3	0.3	0.7	-0.1	0.5	-0.8	-0.7	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.7	-0.1	-0.9	-0.9	-0.5
Basal metabolic rate	0.3	1.9	5.2	0.9	-2.3	0.9	0.6	1.6
Irritability	0.3	0.4	0.9	0.8	-1.0	-0.0	-0.7	-0.3
Ever depressed for a whole week	0.3	0.3	0.5	-0.7	0.6	-0.3	-0.7	0.4
Cholesterol lowering medication	0.3	0.5	1.8	-0.6	1.3	-0.0	-0.0	-0.5
Pain experienced in last month	0.3	0.4	1.9	-0.2	-0.4	-1.4	-0.1	-0.3
Neuroticism (Nagel 2018)	0.2	0.4	1.1	-1.1	0.0	0.2	-0.9	0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	1.1	-0.1	0.1	1.0	0.2	0.5
Blood Red Count	0.2	2.3	5.0	-1.3	-0.9	-2.2	-2.0	0.2
Number of treatments/medications taken	0.2	0.4	0.9	-0.7	0.9	0.5	-0.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	-0.8	0.2	-0.2	-0.3	0.4
Multivitamins +/- minerals	0.2	0.2	0.5	-0.3	0.4	-0.0	-0.7	-0.5
Trunk fat-free mass	0.2	1.2	4.5	-0.1	-2.1	0.4	0.2	1.2
Pulse rate	0.2	0.3	1.1	-1.1	0.3	-0.1	-0.1	0.4
Illnesses of mother	0.2	0.2	0.5	-0.6	-0.7	0.5	0.4	0.0
Trunk predicted mass	0.2	1.2	4.4	-0.0	-2.1	0.4	0.2	1.1
Birth weight of first child	0.2	0.3	0.6	0.6	-0.8	-0.0	-0.4	-0.6
Blood clot in the leg (DVT)	0.2	0.3	0.7	-0.0	-0.9	-0.1	0.4	0.7
Headache pain in last month	0.2	0.3	0.8	-0.9	-0.5	0.4	-0.4	0.2
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.2	0.6	0.6	0.4	-0.5
Worry too long after embarrassment	0.2	0.3	0.7	0.9	-0.6	0.4	0.4	-0.3
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	0.5	0.3	0.6	-0.4	0.7
Migraine (self-reported)	0.2	0.3	0.6	-0.3	0.8	0.1	0.6	0.7
Loneliness, isolation	0.2	0.2	0.9	-0.4	0.1	-0.1	0.1	-1.0
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.4	0.5	0.1	-0.8	0.6
Back pain experienced in last month	0.2	0.3	0.6	0.3	-0.5	-0.0	-0.7	0.8
Mineral and other dietary supplements	0.2	0.2	0.5	-0.5	-0.3	-0.4	0.4	-0.7
Asthma (self-reported)	0.2	0.5	1.6	0.6	0.5	1.3	-0.3	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.7	-0.0	-0.4	0.5	0.8	0.3
Whole body water mass	0.2	1.4	4.5	0.5	-2.1	0.6	0.4	1.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.5	0.8	0.7	0.4	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.3	0.4	0.3	-0.3	-0.7
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	-0.5	-0.2	-0.3	-0.1
Blood Eosinophil Count	0.1	0.7	2.9	-1.7	-0.1	-0.5	-0.0	0.6
Heel T-Score	0.1	1.1	4.3	-0.1	0.4	-0.7	0.8	-2.1
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.7	0.6	0.4	-0.1	0.5	-0.8
Lung FVC	0.1	0.3	0.6	-0.6	0.7	-0.1	-0.8	0.0
Neuroticism	0.1	0.3	0.8	-0.9	-0.6	0.3	-0.1	0.5
Tanning	0.1	1.5	3.9	2.0	0.1	1.7	0.9	-0.0
Relative age of first facial hair	0.1	0.2	0.5	0.4	0.7	-0.3	0.2	-0.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.5	-0.0	-0.7	-0.4	0.0	0.1
Angina	0.1	0.1	0.5	-0.7	0.1	-0.1	-0.0	-0.2
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.0	-0.2	-0.2	0.5	0.3
Average weekly fortified wine intake	0.1	0.1	0.4	0.2	0.2	-0.6	-0.4	-0.2
Relative age voice broke	0.1	0.1	0.4	-0.5	-0.6	0.1	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.5	-0.2	0.5	0.7	-0.1
Supplements: Glucosamine	0.1	0.1	0.3	0.4	-0.0	0.5	0.4	0.1
Qualifications: None of the above	0.1	0.3	0.6	0.4	-0.7	-0.3	0.8	0.4
Neuroticism score	0.1	0.3	0.7	-0.3	-0.4	0.9	-0.0	0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.8	-0.2	-0.3	0.2	0.3
Length of working week for main job	0.1	0.1	0.4	0.2	-0.4	-0.1	0.3	-0.6
Tense / ‘highly strung’	0.1	0.2	0.4	-0.2	0.5	0.4	0.0	0.6
Peak expiratory flow (PEF)	0.1	0.3	1.2	0.3	0.2	-0.3	-0.1	-1.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.4	0.7	0.3	0.0	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	0.2	-0.1	-0.3	1.0	-0.3
Age at first live birth	0.1	0.2	0.6	0.2	-0.4	0.8	0.3	0.1
Angina (self-reported)	0.1	0.1	0.5	-0.7	0.1	0.1	-0.0	-0.2
Pulse rate, automated reading	0.1	0.4	1.7	-0.6	-1.3	0.1	-0.4	0.2
Comparative height size at age 10	0.1	0.6	1.1	1.1	0.8	0.9	0.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.4	-0.0	-0.3	0.2	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.5	-0.2	0.7	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.7	-0.2	0.6	0.4	0.4
Average weekly champagne plus white wine intake	0.1	0.2	0.5	0.1	0.1	0.3	0.7	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.1	0.2	0.0	0.0	0.2	0.5	-0.4
Waist Hip Ratio (WHR)	0.0	0.2	0.4	0.6	-0.1	0.6	0.0	0.1

Hub : Genes

WDR45B

Models

Trait associations