Hub : Genes

WDR49

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0900	0.0300	2.1e-06	0.022	0.038	0.023	0.041	0.021	0.00096	1.7e-05	6.6e-04	9.3e-06	0.00110
2	TCGA	Breast Invasive Carcinoma	0.0197	0.0106	3.9e-03	0.014	0.008	0.007	NA	0.007	0.00053	6.1e-03	1.0e-02	NA	0.00990
3	TCGA	Brain Lower Grade Glioma	0.2002	0.1054	6.2e-04	0.019	0.019	0.037	NA	0.023	0.00280	2.8e-03	4.1e-05	NA	0.00098

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	3.1	4.9	10.0	3.2	-2.1	-0.7
Bipolar Disorder or Schizophrenia	0.8	2.0	4.3	2.1	-1.2	-0.4
Depressed Affect (Nagel 2018)	1.1	2.4	5.1	1.3	0.7	2.3
Depression (Nagel 2018)	2.0	3.0	5.4	1.4	1.3	2.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.9	-0.5	-0.4
Neuroticism (Nagel 2018)	0.9	2.2	5.6	0.1	1.0	2.4
Schizophrenia (2018)	0.0	0.0	0.0	0.1	0.1	0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	-0.9	0.4	0.7
Worry (Nagel 2018)	1.0	2.1	4.3	-1.2	0.7	2.1
Alzheimer’s Disease (in mother)	2.2	2.6	4.6	1.3	2.1	1.3
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.2	0.9	-0.8
Alzheimer’s Disease (including proxy)	1.8	2.6	6.4	0.7	2.5	1.0
Crohns Disease (2017)	0.4	0.9	1.9	-0.2	1.4	0.8
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	-0.1	0.5	0.1
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.0	-0.5	-0.4
Major Depression (MDD)	0.5	0.6	1.6	1.3	-0.4	0.4
Reaction Time	2.0	3.8	5.0	2.0	-1.4	-2.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	0.5	-0.4	-0.9
Breast Cancer	0.2	0.5	1.4	-1.2	-0.3	0.1
Ovarian Cancer	0.0	0.1	0.2	0.4	0.1	-0.1
Prostate Cancer	1.5	2.1	2.9	-1.7	1.3	1.3
Age at First Birth	3.5	5.1	7.4	2.2	-2.7	-1.7
Bipolar Disorder (2011)	1.4	1.3	2.9	1.1	-1.7	0.1
Body Mass Index (BMI) (2010)	0.8	1.1	1.5	-0.9	1.0	-1.2
Coronary Artery Disease (CAD)	0.5	0.5	1.0	0.1	-1.0	0.8
Crohns Disease (2012)	0.1	0.2	0.3	0.4	0.6	0.5
Mean Putamen Volume	1.4	1.7	3.4	0.6	-1.1	-1.8
Fasting Glucose	0.1	0.2	0.4	0.2	-0.7	0.0
HbA1C	0.1	0.1	0.1	-0.3	-0.3	-0.0
HDL Cholesterol	0.2	0.3	1.0	0.0	1.0	-0.2
LDL Cholesterol	0.2	0.4	0.8	0.9	0.1	-0.6
Lupus	0.4	0.7	1.7	-1.3	-0.5	-0.2
Neuroticism (2016)	0.2	0.3	0.9	-0.2	0.9	0.3
Primary Biliary Cirrhosis	0.5	0.8	1.1	0.5	0.9	1.1
Rheumatoid Arthritis	0.3	0.4	0.8	-0.9	0.4	-0.3
Schizophrenia (2014)	0.6	1.2	2.0	1.2	-1.4	-0.5
Triglycerides	0.2	0.4	0.9	0.2	1.0	0.3
Type 2 Diabetes (T2D) (2012)	1.4	1.6	4.4	0.2	-2.1	-0.7
Ulcerative Colitis	0.2	0.3	0.5	0.4	-0.7	-0.5
Blood Eosinophil Count	0.6	4.6	13.6	-3.7	0.3	-0.1
Blood Platelet Count	2.8	33.0	86.1	-9.3	1.1	3.4
Blood Red Count	0.2	2.3	6.2	-2.5	0.2	-0.9
Blood White Count	0.5	3.4	5.3	-1.1	2.3	1.9
Heel T-Score	0.2	1.4	3.1	0.3	1.8	-1.1
BMI	0.3	1.6	2.1	-1.3	1.4	0.9
Height	0.1	2.3	4.5	2.1	-1.3	-0.9
Waist Hip Ratio (WHR)	0.5	2.3	4.8	1.4	-2.2	-0.5
Systolic Blood Pressure	2.0	9.8	17.6	-2.1	4.2	2.7
Smoking Status	3.5	8.4	15.0	1.1	3.9	3.0
Allergy or Eczema	0.7	2.0	5.1	0.7	-2.3	-0.5
Cardiovascular Disease	0.9	3.0	7.0	-1.1	2.7	0.9
Hypothyroidism (self reported)	0.7	1.5	4.0	-0.2	-2.0	-0.7
Respiratory disease	0.3	0.8	0.9	0.8	1.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.3	-0.8	1.8	-0.9
Lung FEV1/FVC ratio	0.9	4.7	9.3	-0.3	2.1	3.0
Lung FVC	0.0	0.1	0.1	0.3	0.1	0.2
Neuroticism	0.5	1.1	2.7	0.8	0.1	1.7
Chronotype (morning person)	0.3	0.7	2.0	0.1	-1.4	-0.3
Hair Pigment	0.1	2.2	3.0	-1.7	-1.4	-1.3
Tanning	0.2	2.3	3.3	0.9	1.8	1.7
Hand grip strength (left)	0.4	1.0	1.9	1.4	0.5	0.9
Number of treatments/medications taken	0.6	1.1	1.7	-0.5	1.2	1.3
Average weekly spirits intake	2.6	3.3	5.4	-1.3	2.3	1.7
Sensitivity / hurt feelings	0.8	1.4	1.8	1.3	1.1	1.2
Frequency of depressed mood in last 2 weeks	1.6	2.3	3.4	1.9	0.6	1.8
Hearing difficulty/problems: Yes	0.7	1.0	1.8	-0.2	1.3	1.1
Relative age of first facial hair	0.1	0.1	0.3	0.5	-0.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.0	0.7	1.0	0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.8	-0.9	-0.3	0.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	-0.5	1.2	0.5
Systolic blood pressure, automated reading	2.8	8.1	15.1	-2.4	3.9	1.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.0	0.7	0.3
Angina	0.5	0.6	1.1	-0.8	1.1	0.2
Medication for hormone replacement therapy	1.3	1.4	3.7	0.6	-1.9	-0.3
Vitamin and mineral supplements	0.7	0.9	2.0	-0.8	1.4	0.2
Supplements: Zinc	0.1	0.1	0.2	-0.1	0.5	-0.4
Medication: Co-codamol	1.3	1.5	2.6	-1.3	0.6	1.6
Medication: Metformin	0.9	1.3	2.7	-0.7	-0.8	-1.6
Diabetes (father)	0.8	1.0	2.9	-0.3	1.7	0.1
Diabetes (mother)	1.1	1.4	3.8	-0.6	2.0	-0.1
Severe depression (siblings)	0.4	0.4	0.8	0.9	-0.4	-0.5
Pack years adult smoking proportion	0.3	0.4	1.2	0.0	0.1	-1.1
Impedance of leg (right)	0.2	1.2	2.1	0.7	-1.4	0.9
Leg fat-free mass (left)	0.0	0.1	0.1	0.3	-0.2	0.3
Trunk fat percentage	0.2	0.6	1.6	-1.3	-0.3	-0.5
Hand grip strength (right)	0.2	0.5	1.0	1.0	0.3	0.7
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.4	0.8	0.2
Current tobacco smoking	4.0	6.5	12.7	1.2	3.6	2.4
Average weekly fortified wine intake	0.5	0.6	1.4	-0.1	-1.2	0.5
Maternal smoking around birth	1.9	2.8	3.3	-1.4	1.8	1.8
Fed-up feelings	1.2	2.2	4.0	2.0	-0.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.3	2.3	0.3	1.2
Relative age voice broke	0.1	0.2	0.2	0.3	-0.4	-0.4
Taking other prescription medications	0.2	0.3	1.0	0.1	0.1	1.0
Age when periods started (menarche)	0.5	1.1	3.0	-0.4	0.3	1.7
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.0	0.3	1.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.1	-1.8	0.9	-0.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	0.9	0.4	0.9	0.9
Qualifications: CSEs or equivalent	1.0	1.3	3.3	-0.2	1.8	0.7
Serious illness, injury or assault to yourself	0.3	0.4	1.2	-0.1	1.1	-0.0
High blood pressure	1.5	4.1	9.8	-1.4	3.1	0.8
Hayfever, allergic rhinitis or eczema	0.7	1.4	4.2	0.0	-2.0	0.2
Multivitamins +/- minerals	0.6	0.7	1.1	-0.0	-1.0	-1.1
Stomach or abdominal pain in last month	1.0	1.2	3.5	-0.2	0.2	1.9
Supplements: Glucosamine	0.6	0.8	1.4	0.1	-0.9	-1.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.3	0.4	-0.0
Medication: Atenolol	1.8	2.3	3.9	-0.9	1.5	2.0
Medication: Levothyroxine sodium	0.7	1.2	1.8	-1.3	-1.1	-0.8
Sitting height	0.0	0.3	0.5	0.6	-0.2	-0.7
Chronic bronchitis/emphysema (father)	1.0	1.1	1.7	1.3	0.9	-1.0
High blood pressure (mother)	0.3	0.5	1.2	-1.1	0.3	0.4
Body mass index (BMI)	0.4	1.5	3.1	-1.8	1.2	0.1
Impedance of leg (left)	0.1	0.6	1.4	0.7	-1.2	-0.1
Leg predicted mass (left)	0.0	0.1	0.2	0.2	-0.2	0.4
Trunk fat mass	0.1	0.3	0.4	-0.6	-0.3	-0.6
Waist circumference	0.1	0.4	0.9	-0.9	-0.5	-0.2
Number of incorrect matches in round	0.5	0.8	1.9	0.3	1.4	0.6
Past tobacco smoking	0.8	1.5	3.3	-0.5	-1.8	-1.0
Alcohol usually taken with meals	0.2	0.3	0.5	0.5	-0.6	-0.7
Nervous feelings	0.3	0.6	1.3	-1.1	-0.2	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.0	0.4	1.7	1.5
Hearing difficulty/problems with background noise	0.5	0.8	1.3	-0.8	0.7	1.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	-0.6	-0.1	0.3
Had menopause	2.3	2.8	7.2	-2.7	1.0	-0.5
Had other major operations	0.1	0.2	0.3	-0.2	0.5	0.5
Forced vital capacity (FVC)	0.3	1.0	1.3	1.2	-0.7	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	2.6	-1.6	1.1	-1.5
Ever unenthusiastic/disinterested for a whole week	3.1	3.8	6.5	-0.8	2.0	2.6
Qualifications: None of the above	1.9	4.1	7.1	-2.2	2.7	0.3
Financial difficulties in last 2 years	0.5	0.7	1.9	0.3	0.1	1.4
Mouth/teeth dental problems	0.6	0.9	1.3	0.9	0.7	1.2
Heart attack	1.2	1.5	2.8	0.0	1.7	1.3
Allergy	0.3	0.7	1.8	-0.6	1.4	0.1
Pain all over the body in last month	0.4	0.4	0.8	-0.9	0.1	0.7
Diabetes (self-reported)	1.2	1.9	2.4	-1.6	1.3	-1.2
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	5.5	0.3	-2.3	-1.4
Medication: Ramipril	0.9	1.2	2.0	-1.1	1.4	0.6
Medication: Simvastatin	0.6	0.8	2.4	-0.2	1.5	-0.1
Fluid intelligence score	0.4	0.9	1.9	0.4	-0.8	-1.4
Illnesses of siblings	1.4	2.0	3.7	-1.0	-1.9	-1.1
Neuroticism score	0.7	1.5	4.3	0.0	0.5	2.1
Weight	0.0	0.2	0.4	-0.6	-0.1	-0.4
Impedance of arm (right)	0.5	2.6	7.3	0.4	-2.7	-0.4
Arm fat percentage (right)	0.2	0.7	1.7	-1.3	0.6	0.1
Trunk fat-free mass	0.1	0.9	2.3	1.5	-0.5	0.2
Hip circumference	0.1	0.5	1.3	-1.2	-0.2	-0.1
Time employed in main current job	0.8	0.9	1.8	-1.4	0.8	0.5
Alcohol intake versus 10 years previously	1.5	2.3	4.3	-2.1	1.2	1.1
Father’s age at death	0.4	0.5	1.3	1.2	-0.5	0.0
Worrier / anxious feelings	2.8	5.3	9.5	-0.6	3.1	2.5
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	3.2	1.3	1.7	1.8
Falls in the last year	0.2	0.2	0.5	0.7	-0.4	0.1
Hair/balding pattern: Pattern 3	0.6	1.0	2.7	1.6	-0.3	-0.3
Number of live births	1.9	2.7	4.0	-1.7	2.0	1.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.0	0.7	-0.3	1.7
Pulse rate	0.1	0.3	0.6	0.8	-0.4	-0.1
Happiness	2.0	2.4	4.9	2.2	1.0	1.2
Noisy workplace	1.2	1.5	1.9	-1.4	1.4	-0.8
Qualifications: A levels/AS levels or equivalent	4.2	9.4	17.4	4.2	-3.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.0	1.7	-0.8	0.5
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	0.8	-0.3	-0.8
Asthma	0.1	0.2	0.3	-0.6	0.5	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.4	0.6	-0.1	1.8
Medication: Cholesterol lowering	0.2	0.4	1.0	1.0	0.0	0.2
Depression (self-reported)	2.8	3.4	4.5	1.7	1.7	2.1
Medication: Lansoprazole	0.1	0.1	0.3	0.2	0.5	0.3
Prospective memory result	0.8	1.0	1.9	0.7	1.4	0.9
Lung cancer (father)	0.3	0.3	1.0	-1.0	-0.1	0.1
Illnesses of mother	0.8	1.0	1.7	-1.2	-1.3	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.9	1.0	-0.5	0.9
Pulse wave Arterial Stiffness index	2.3	2.7	4.6	1.6	-2.1	-1.0
Impedance of arm (left)	0.6	2.6	7.7	-0.2	-2.8	-0.3
Arm fat mass (right)	0.1	0.4	1.0	-1.0	0.4	0.0
Trunk predicted mass	0.1	0.8	2.0	1.4	-0.5	0.3
Standing height	0.5	4.9	7.3	2.5	-2.7	-1.0
Length of working week for main job	1.2	1.3	1.7	-1.0	1.1	1.3
Exposure to tobacco smoke at home	1.0	1.1	3.2	-1.8	-0.5	0.1
Breastfed as a baby	1.8	2.2	4.1	2.0	-1.6	-0.2
Tense / ‘highly strung’	0.4	0.6	1.9	0.2	-0.1	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	3.9	6.8	-0.1	2.6	2.2
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	-0.0	-1.0	0.2
Birth weight of first child	0.2	0.5	0.8	-0.3	-0.9	0.7
Peak expiratory flow (PEF)	0.3	0.8	1.5	0.1	-1.2	1.0
Pulse wave reflection index	0.6	0.7	1.3	0.3	-1.1	-0.9
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.9	0.7	0.7	1.7
Loud music exposure frequency	0.2	0.2	0.3	-0.4	0.5	0.4
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	5.1	2.3	-1.7	-0.4
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	4.0	-1.5	-2.0	-0.0
Blood clot in the leg (DVT)	0.2	0.2	0.6	0.1	0.0	-0.8
Medication: Paracetamol	1.5	2.5	4.8	-0.7	1.5	2.2
Headache pain in last month	0.7	1.3	2.8	1.7	0.2	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.3	0.9	-1.1	-1.0
Glaucoma (self-reported)	0.1	0.2	0.4	-0.6	-0.1	-0.3
Gout (self-reported)	1.5	2.1	6.0	-2.4	-0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.0	-0.3	-2.0	-0.2
Medication: Amlodipine	0.7	1.0	1.5	-1.2	1.2	0.2
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.1	-1.8	1.4	-0.3
Birth weight	0.3	0.7	1.6	1.3	-0.4	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	0.8	0.3	0.2
High blood pressure (siblings)	2.0	2.9	8.4	0.6	2.9	0.1
Forced vital capacity (FVC), Best measure	0.3	0.9	1.8	1.3	-1.0	0.3
Body fat percentage	0.2	0.6	1.9	-1.4	0.2	-0.1
Leg fat percentage (right)	0.2	0.6	1.5	-1.2	0.5	0.1
Arm fat-free mass (right)	0.0	0.2	0.3	0.6	0.2	0.3
Exposure to tobacco smoke outside home	0.7	0.9	1.3	-1.2	0.5	-1.1
Comparative body size at age 10	0.2	0.6	1.5	0.1	0.6	-1.2
Number of full brothers	0.5	0.6	1.7	-0.1	1.3	-0.3
Worry too long after embarrassment	0.8	1.3	2.3	-0.5	1.1	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	1.1	0.5	0.8
Wheeze or whistling in the chest in last year	0.5	1.0	1.3	-0.6	1.1	1.1
Number of children fathered	2.0	2.2	5.1	0.5	2.3	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.1	-1.4	-1.1	-1.2
Age at first live birth	1.3	2.4	3.1	1.6	-1.8	-1.2
Pulse wave peak to peak time	1.9	2.2	3.9	-1.3	2.0	1.0
Health satisfaction	1.9	2.5	3.4	1.0	1.9	1.8
Shortness of breath walking on level ground	0.4	0.5	0.6	-0.7	0.6	0.8
Qualifications: College or University degree	0.9	2.8	4.3	2.1	-2.0	0.1
Eye problems/disorders: None of the above	0.7	0.8	1.3	-1.2	0.7	0.7
Mouth/teeth dental problems: Loose teeth	2.7	3.2	4.4	1.2	-2.0	-2.1
Emphysema/chronic bronchitis	0.7	0.8	2.1	-0.5	-0.4	-1.4
Medication for pain relief, constipation, heartburn	1.3	2.3	3.6	0.0	-1.8	-1.9
Neck or shoulder pain in last month	2.2	3.2	5.4	-1.4	2.3	1.4
Medication: Blood pressure	1.3	2.4	4.1	-1.1	2.0	1.3
Angina (self-reported)	0.7	0.9	1.6	-0.9	1.2	0.6
Migraine (self-reported)	0.5	0.7	1.5	0.7	-1.2	-0.1
Medication: Ibuprofen	1.6	1.9	3.6	1.2	-0.8	1.9
Medication: Allopurinol	1.1	1.5	3.9	-2.0	-0.7	0.0
Medication: Omeprazole	0.5	0.6	0.9	0.1	-0.9	-0.9
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.1	0.8	-0.0
Mean time to correctly identify matches	2.1	4.0	6.7	1.5	-1.7	-2.6
Heart disease (mother)	1.4	1.7	3.8	-0.4	1.9	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.4	-1.1	0.0	1.5
Whole body fat mass	0.1	0.3	0.7	-0.8	0.3	0.1
Leg fat mass (right)	0.1	0.3	0.7	-0.8	0.6	0.2
Arm predicted mass (right)	0.0	0.2	0.3	0.6	0.3	0.3
Pulse rate, automated reading	0.1	0.3	0.5	0.7	-0.3	-0.3
Alcohol intake frequency.	0.1	0.3	0.5	-0.0	-0.5	-0.7
Comparative height size at age 10	0.7	4.0	5.2	2.2	-1.4	-2.3
Number of full sisters	1.4	1.7	2.5	-0.2	1.6	1.6
Suffer from ‘nerves’	0.2	0.3	0.4	0.3	0.6	0.7
Overall health rating	2.9	6.2	14.7	-1.1	3.8	1.6
Chest pain or discomfort	0.9	1.3	2.5	-0.8	1.6	0.8
Had major operations	0.2	0.3	0.6	0.8	0.1	0.4
Age at last live birth	0.7	1.0	2.0	0.8	-1.4	-0.6
Family relationship satisfaction	0.8	1.0	2.2	1.5	0.0	0.9
Leg pain on walking	0.8	1.0	1.8	-1.0	0.2	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.4	-1.2	-1.1	-0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.6	0.7	-0.1	0.8
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	5.6	-0.8	-2.4	-0.0
Medication: Aspirin	0.8	1.1	1.4	1.0	1.2	0.9
Supplements: Vitamin C	0.4	0.5	1.2	-1.1	-0.2	0.4
Knee pain experienced in last month	2.8	4.3	5.7	-2.4	1.5	2.2
Hypertension (Self-reported)	1.1	3.0	7.2	-1.3	2.7	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	0.4	-0.5	0.2
Illnesses of father: Heart disease	1.2	1.7	2.7	-0.7	1.3	1.6
Illnesses of siblings: Diabetes	0.7	0.8	1.4	1.2	-0.5	-0.9
Smoking status: Previous	0.1	0.2	0.3	-0.1	0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.7	1.6	-0.9	1.1
Whole body fat-free mass	0.1	0.3	0.9	0.9	-0.3	0.1
Leg fat-free mass (right)	0.0	0.0	0.1	0.3	-0.2	-0.2
Arm fat percentage (left)	0.2	1.0	2.7	-1.7	0.4	0.1
Average weekly red wine intake	0.3	0.4	1.0	-0.5	-1.0	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	0.8	-0.1	0.2
Mood swings	0.8	1.4	2.4	1.5	0.2	1.4
Loneliness, isolation	1.7	2.4	6.0	0.4	1.0	2.4
Long-standing illness, disability or infirmity	0.8	1.2	3.1	0.3	1.8	0.7
Ever had bowel cancer screening	0.1	0.2	0.2	0.4	0.5	-0.3
Diabetes diagnosed by doctor	1.3	2.2	2.7	-1.6	1.6	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.5	-0.4	-0.3
Friendships satisfaction	0.7	0.8	1.5	1.2	-0.7	-0.7
Qualifications: nursing, teaching	4.0	6.3	11.2	3.3	-2.8	0.1
Commuting to job workplace: Walk	0.8	0.8	1.2	-1.1	0.4	-1.0
Eye problems/disorders: Cataract	0.5	0.5	1.6	1.3	0.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.6	-0.7	0.8	0.2
Medication for cholesterol	0.5	0.7	1.2	1.1	-0.9	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.4	-1.1	-0.2	-1.2
Back pain experienced in last month	2.8	4.1	10.8	-0.4	1.2	3.3
Mineral and other dietary supplements	0.1	0.1	0.4	-0.1	0.6	0.1
Breast cancer (self-reported)	1.5	1.8	4.2	-0.6	-1.0	-2.0
Asthma (self-reported)	0.1	0.2	0.4	-0.6	0.5	-0.1
Osteoporosis (self-reported)	1.1	1.3	2.9	-0.2	-1.0	-1.7
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.4	-0.2	0.6
Medication: Aspirin	0.7	0.8	1.1	0.9	1.0	0.8
Medication: Gliclazide	1.6	1.8	2.0	-1.4	1.3	-1.3
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	-0.7	-0.7	-0.4
Smoking status: Current	4.3	6.8	14.1	0.9	3.8	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	0.3	-0.1	-0.4
Whole body water mass	0.1	0.3	0.8	0.9	-0.3	0.0
Leg predicted mass (right)	0.0	0.1	0.1	0.3	-0.3	-0.2
Arm fat mass (left)	0.2	0.6	1.6	-1.3	0.5	0.2
Number of self-reported non-cancer illnesses	0.1	0.3	0.7	0.3	0.8	0.0
Average weekly champagne plus white wine intake	0.9	1.2	3.1	0.7	-1.8	-0.4
Miserableness	0.2	0.3	0.7	0.5	-0.1	0.8
Guilty feelings	0.8	1.3	2.5	-1.1	0.1	1.6
Wears glasses or contact lenses	0.2	0.2	0.3	0.4	0.5	0.4
Ever taken oral contraceptive pill	0.3	0.4	0.9	0.9	-0.4	-0.0
Hearing aid user	0.1	0.1	0.4	-0.2	0.6	0.1
Mother’s age at death	1.9	2.4	4.7	1.4	-2.2	-0.7
Financial situation satisfaction	3.0	3.7	6.4	0.3	2.5	2.1
Tinnitus: Yes, now most or all of the time	4.1	4.8	9.7	2.1	-3.1	-0.8
Commuting to job workplace: Public transport	1.4	1.7	4.4	0.7	-0.5	-2.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	-0.0	-0.2	-0.7
Medication: Blood pressure	0.8	1.6	2.1	-1.4	1.1	-1.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.7	-0.1	-0.0	0.9
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	-0.2	-0.4	0.6
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.3	-0.0	0.1
Medication: Bendroflumethiazide	1.2	1.8	3.7	-1.3	1.9	-0.1
Medication: Paracetamol	1.6	2.6	6.5	0.2	1.0	2.6
Medication: Lisinopril	1.7	2.2	6.4	-0.1	2.5	-0.4
Medication: Atorvastatin	0.6	0.8	1.2	0.3	1.1	1.0
Illnesses of father: High blood pressure	1.1	1.4	3.0	-0.9	1.7	0.6
Alcohol drinker status: Never	1.3	1.5	4.0	-0.4	-2.0	-0.6
Ever smoked	2.0	3.5	7.5	0.6	2.7	1.6
Basal metabolic rate	0.0	0.2	0.3	0.6	-0.3	0.1
Leg fat percentage (left)	0.2	0.7	1.3	-1.1	0.7	-0.5
Arm fat-free mass (left)	0.0	0.2	0.3	0.6	0.4	0.0
Number of operations (self-reported)	0.2	0.3	0.4	0.5	0.5	0.6
Average weekly beer plus cider intake	0.0	0.0	0.1	-0.3	0.1	-0.1
Irritability	2.4	4.1	6.0	2.5	-2.1	1.3
Risk taking	0.2	0.2	0.4	0.6	0.1	0.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.3	-0.4	1.5	-0.7
Fractured/broken bones in last 5 years	0.3	0.4	0.9	-0.9	0.4	0.2
Age started oral contraceptive pill	0.4	0.5	1.0	-0.1	-1.0	0.6
Diastolic blood pressure, automated reading	1.5	4.7	11.7	-1.5	3.4	0.1
Ever depressed for a whole week	2.7	3.3	3.9	-1.6	2.0	1.9
Unable to work because of sickness or disability	0.4	0.5	0.8	0.9	-0.8	0.2
Commuting to job workplace: Cycle	2.1	2.6	5.8	2.4	-0.4	1.3
Myopia	0.7	1.1	2.0	0.4	-1.4	-1.0
Vascular/heart problems diagnosed by doctor	1.5	4.1	9.0	1.4	-3.0	-1.1
Cholesterol lowering medication	1.1	1.6	2.8	-1.4	1.7	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	0.8	-0.4	-0.6
Pain experienced in last month	4.7	7.8	14.3	1.5	-2.6	-3.8
Supplements: Calcium	0.0	0.0	0.1	0.3	0.0	-0.2
Basal cell carcinoma (self-reported)	1.5	1.8	3.7	1.9	0.2	-1.2
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.8	-0.1	1.7	1.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.2	-0.1	-0.7
Heart disease (siblings)	0.6	0.8	2.0	-0.6	0.3	1.4
Alcohol drinker status: Previous	3.2	3.6	5.2	2.2	-2.3	-0.9
Pack years of smoking	0.4	0.6	1.7	0.3	-0.4	-1.3
Impedance of whole body	0.4	1.9	5.3	0.2	-2.3	-0.4
Leg fat mass (left)	0.1	0.4	0.6	-0.8	0.7	0.1
Arm predicted mass (left)	0.0	0.1	0.2	0.5	0.3	0.2