Hub : Genes

WDR49

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0900 0.0300 2.1e-06 0.022 0.038 0.023 0.041 0.021 0.00096 1.7e-05 6.6e-04 9.3e-06 0.00110
2 TCGA Breast Invasive Carcinoma 0.0197 0.0106 3.9e-03 0.014 0.008 0.007 NA 0.007 0.00053 6.1e-03 1.0e-02 NA 0.00990
3 TCGA Brain Lower Grade Glioma 0.2002 0.1054 6.2e-04 0.019 0.019 0.037 NA 0.023 0.00280 2.8e-03 4.1e-05 NA 0.00098

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 3.1 4.9 10.0 3.2 -2.1 -0.7
Bipolar Disorder or Schizophrenia 0.8 2.0 4.3 2.1 -1.2 -0.4
Depressed Affect (Nagel 2018) 1.1 2.4 5.1 1.3 0.7 2.3
Depression (Nagel 2018) 2.0 3.0 5.4 1.4 1.3 2.3
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.8 0.9 -0.5 -0.4
Neuroticism (Nagel 2018) 0.9 2.2 5.6 0.1 1.0 2.4
Schizophrenia (2018) 0.0 0.0 0.0 0.1 0.1 0.1
Schizophrenia vs Biploar Disorder 0.4 0.5 0.9 -0.9 0.4 0.7
Worry (Nagel 2018) 1.0 2.1 4.3 -1.2 0.7 2.1
Alzheimer’s Disease (in mother) 2.2 2.6 4.6 1.3 2.1 1.3
Alzheimer’s Disease (in father) 0.5 0.5 0.8 0.2 0.9 -0.8
Alzheimer’s Disease (including proxy) 1.8 2.6 6.4 0.7 2.5 1.0
Crohns Disease (2017) 0.4 0.9 1.9 -0.2 1.4 0.8
Irritable Bowel Disease (IBD) 0.0 0.1 0.2 -0.1 0.5 0.1
Ulcerative Colitis (UC) 0.1 0.1 0.2 -0.0 -0.5 -0.4
Major Depression (MDD) 0.5 0.6 1.6 1.3 -0.4 0.4
Reaction Time 2.0 3.8 5.0 2.0 -1.4 -2.2
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.8 0.5 -0.4 -0.9
Breast Cancer 0.2 0.5 1.4 -1.2 -0.3 0.1
Ovarian Cancer 0.0 0.1 0.2 0.4 0.1 -0.1
Prostate Cancer 1.5 2.1 2.9 -1.7 1.3 1.3
Age at First Birth 3.5 5.1 7.4 2.2 -2.7 -1.7
Bipolar Disorder (2011) 1.4 1.3 2.9 1.1 -1.7 0.1
Body Mass Index (BMI) (2010) 0.8 1.1 1.5 -0.9 1.0 -1.2
Coronary Artery Disease (CAD) 0.5 0.5 1.0 0.1 -1.0 0.8
Crohns Disease (2012) 0.1 0.2 0.3 0.4 0.6 0.5
Mean Putamen Volume 1.4 1.7 3.4 0.6 -1.1 -1.8
Fasting Glucose 0.1 0.2 0.4 0.2 -0.7 0.0
HbA1C 0.1 0.1 0.1 -0.3 -0.3 -0.0
HDL Cholesterol 0.2 0.3 1.0 0.0 1.0 -0.2
LDL Cholesterol 0.2 0.4 0.8 0.9 0.1 -0.6
Lupus 0.4 0.7 1.7 -1.3 -0.5 -0.2
Neuroticism (2016) 0.2 0.3 0.9 -0.2 0.9 0.3
Primary Biliary Cirrhosis 0.5 0.8 1.1 0.5 0.9 1.1
Rheumatoid Arthritis 0.3 0.4 0.8 -0.9 0.4 -0.3
Schizophrenia (2014) 0.6 1.2 2.0 1.2 -1.4 -0.5
Triglycerides 0.2 0.4 0.9 0.2 1.0 0.3
Type 2 Diabetes (T2D) (2012) 1.4 1.6 4.4 0.2 -2.1 -0.7
Ulcerative Colitis 0.2 0.3 0.5 0.4 -0.7 -0.5
Blood Eosinophil Count 0.6 4.6 13.6 -3.7 0.3 -0.1
Blood Platelet Count 2.8 33.0 86.1 -9.3 1.1 3.4
Blood Red Count 0.2 2.3 6.2 -2.5 0.2 -0.9
Blood White Count 0.5 3.4 5.3 -1.1 2.3 1.9
Heel T-Score 0.2 1.4 3.1 0.3 1.8 -1.1
BMI 0.3 1.6 2.1 -1.3 1.4 0.9
Height 0.1 2.3 4.5 2.1 -1.3 -0.9
Waist Hip Ratio (WHR) 0.5 2.3 4.8 1.4 -2.2 -0.5
Systolic Blood Pressure 2.0 9.8 17.6 -2.1 4.2 2.7
Smoking Status 3.5 8.4 15.0 1.1 3.9 3.0
Allergy or Eczema 0.7 2.0 5.1 0.7 -2.3 -0.5
Cardiovascular Disease 0.9 3.0 7.0 -1.1 2.7 0.9
Hypothyroidism (self reported) 0.7 1.5 4.0 -0.2 -2.0 -0.7
Respiratory disease 0.3 0.8 0.9 0.8 1.0 -0.9
Type 2 Diabetes (T2D) (2018) 0.8 1.6 3.3 -0.8 1.8 -0.9
Lung FEV1/FVC ratio 0.9 4.7 9.3 -0.3 2.1 3.0
Lung FVC 0.0 0.1 0.1 0.3 0.1 0.2
Neuroticism 0.5 1.1 2.7 0.8 0.1 1.7
Chronotype (morning person) 0.3 0.7 2.0 0.1 -1.4 -0.3
Hair Pigment 0.1 2.2 3.0 -1.7 -1.4 -1.3
Tanning 0.2 2.3 3.3 0.9 1.8 1.7
Hand grip strength (left) 0.4 1.0 1.9 1.4 0.5 0.9
Number of treatments/medications taken 0.6 1.1 1.7 -0.5 1.2 1.3
Average weekly spirits intake 2.6 3.3 5.4 -1.3 2.3 1.7
Sensitivity / hurt feelings 0.8 1.4 1.8 1.3 1.1 1.2
Frequency of depressed mood in last 2 weeks 1.6 2.3 3.4 1.9 0.6 1.8
Hearing difficulty/problems: Yes 0.7 1.0 1.8 -0.2 1.3 1.1
Relative age of first facial hair 0.1 0.1 0.3 0.5 -0.2 -0.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.0 0.7 1.0 0.9
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.8 -0.9 -0.3 0.3
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 -0.5 1.2 0.5
Systolic blood pressure, automated reading 2.8 8.1 15.1 -2.4 3.9 1.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 0.0 0.7 0.3
Angina 0.5 0.6 1.1 -0.8 1.1 0.2
Medication for hormone replacement therapy 1.3 1.4 3.7 0.6 -1.9 -0.3
Vitamin and mineral supplements 0.7 0.9 2.0 -0.8 1.4 0.2
Supplements: Zinc 0.1 0.1 0.2 -0.1 0.5 -0.4
Medication: Co-codamol 1.3 1.5 2.6 -1.3 0.6 1.6
Medication: Metformin 0.9 1.3 2.7 -0.7 -0.8 -1.6
Diabetes (father) 0.8 1.0 2.9 -0.3 1.7 0.1
Diabetes (mother) 1.1 1.4 3.8 -0.6 2.0 -0.1
Severe depression (siblings) 0.4 0.4 0.8 0.9 -0.4 -0.5
Pack years adult smoking proportion 0.3 0.4 1.2 0.0 0.1 -1.1
Impedance of leg (right) 0.2 1.2 2.1 0.7 -1.4 0.9
Leg fat-free mass (left) 0.0 0.1 0.1 0.3 -0.2 0.3
Trunk fat percentage 0.2 0.6 1.6 -1.3 -0.3 -0.5
Hand grip strength (right) 0.2 0.5 1.0 1.0 0.3 0.7
Townsend deprivation index at recruitment 0.2 0.3 0.7 -0.4 0.8 0.2
Current tobacco smoking 4.0 6.5 12.7 1.2 3.6 2.4
Average weekly fortified wine intake 0.5 0.6 1.4 -0.1 -1.2 0.5
Maternal smoking around birth 1.9 2.8 3.3 -1.4 1.8 1.8
Fed-up feelings 1.2 2.2 4.0 2.0 -0.2 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 5.3 2.3 0.3 1.2
Relative age voice broke 0.1 0.2 0.2 0.3 -0.4 -0.4
Taking other prescription medications 0.2 0.3 1.0 0.1 0.1 1.0
Age when periods started (menarche) 0.5 1.1 3.0 -0.4 0.3 1.7
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 2.0 0.3 1.4 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.1 -1.8 0.9 -0.1
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 0.9 0.4 0.9 0.9
Qualifications: CSEs or equivalent 1.0 1.3 3.3 -0.2 1.8 0.7
Serious illness, injury or assault to yourself 0.3 0.4 1.2 -0.1 1.1 -0.0
High blood pressure 1.5 4.1 9.8 -1.4 3.1 0.8
Hayfever, allergic rhinitis or eczema 0.7 1.4 4.2 0.0 -2.0 0.2
Multivitamins +/- minerals 0.6 0.7 1.1 -0.0 -1.0 -1.1
Stomach or abdominal pain in last month 1.0 1.2 3.5 -0.2 0.2 1.9
Supplements: Glucosamine 0.6 0.8 1.4 0.1 -0.9 -1.2
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 -0.3 0.4 -0.0
Medication: Atenolol 1.8 2.3 3.9 -0.9 1.5 2.0
Medication: Levothyroxine sodium 0.7 1.2 1.8 -1.3 -1.1 -0.8
Sitting height 0.0 0.3 0.5 0.6 -0.2 -0.7
Chronic bronchitis/emphysema (father) 1.0 1.1 1.7 1.3 0.9 -1.0
High blood pressure (mother) 0.3 0.5 1.2 -1.1 0.3 0.4
Body mass index (BMI) 0.4 1.5 3.1 -1.8 1.2 0.1
Impedance of leg (left) 0.1 0.6 1.4 0.7 -1.2 -0.1
Leg predicted mass (left) 0.0 0.1 0.2 0.2 -0.2 0.4
Trunk fat mass 0.1 0.3 0.4 -0.6 -0.3 -0.6
Waist circumference 0.1 0.4 0.9 -0.9 -0.5 -0.2
Number of incorrect matches in round 0.5 0.8 1.9 0.3 1.4 0.6
Past tobacco smoking 0.8 1.5 3.3 -0.5 -1.8 -1.0
Alcohol usually taken with meals 0.2 0.3 0.5 0.5 -0.6 -0.7
Nervous feelings 0.3 0.6 1.3 -1.1 -0.2 0.8
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 3.0 0.4 1.7 1.5
Hearing difficulty/problems with background noise 0.5 0.8 1.3 -0.8 0.7 1.1
Hair/balding pattern: Pattern 2 0.1 0.2 0.3 -0.6 -0.1 0.3
Had menopause 2.3 2.8 7.2 -2.7 1.0 -0.5
Had other major operations 0.1 0.2 0.3 -0.2 0.5 0.5
Forced vital capacity (FVC) 0.3 1.0 1.3 1.2 -0.7 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 2.6 -1.6 1.1 -1.5
Ever unenthusiastic/disinterested for a whole week 3.1 3.8 6.5 -0.8 2.0 2.6
Qualifications: None of the above 1.9 4.1 7.1 -2.2 2.7 0.3
Financial difficulties in last 2 years 0.5 0.7 1.9 0.3 0.1 1.4
Mouth/teeth dental problems 0.6 0.9 1.3 0.9 0.7 1.2
Heart attack 1.2 1.5 2.8 0.0 1.7 1.3
Allergy 0.3 0.7 1.8 -0.6 1.4 0.1
Pain all over the body in last month 0.4 0.4 0.8 -0.9 0.1 0.7
Diabetes (self-reported) 1.2 1.9 2.4 -1.6 1.3 -1.2
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 5.5 0.3 -2.3 -1.4
Medication: Ramipril 0.9 1.2 2.0 -1.1 1.4 0.6
Medication: Simvastatin 0.6 0.8 2.4 -0.2 1.5 -0.1
Fluid intelligence score 0.4 0.9 1.9 0.4 -0.8 -1.4
Illnesses of siblings 1.4 2.0 3.7 -1.0 -1.9 -1.1
Neuroticism score 0.7 1.5 4.3 0.0 0.5 2.1
Weight 0.0 0.2 0.4 -0.6 -0.1 -0.4
Impedance of arm (right) 0.5 2.6 7.3 0.4 -2.7 -0.4
Arm fat percentage (right) 0.2 0.7 1.7 -1.3 0.6 0.1
Trunk fat-free mass 0.1 0.9 2.3 1.5 -0.5 0.2
Hip circumference 0.1 0.5 1.3 -1.2 -0.2 -0.1
Time employed in main current job 0.8 0.9 1.8 -1.4 0.8 0.5
Alcohol intake versus 10 years previously 1.5 2.3 4.3 -2.1 1.2 1.1
Father’s age at death 0.4 0.5 1.3 1.2 -0.5 0.0
Worrier / anxious feelings 2.8 5.3 9.5 -0.6 3.1 2.5
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 3.2 1.3 1.7 1.8
Falls in the last year 0.2 0.2 0.5 0.7 -0.4 0.1
Hair/balding pattern: Pattern 3 0.6 1.0 2.7 1.6 -0.3 -0.3
Number of live births 1.9 2.7 4.0 -1.7 2.0 1.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 3.0 0.7 -0.3 1.7
Pulse rate 0.1 0.3 0.6 0.8 -0.4 -0.1
Happiness 2.0 2.4 4.9 2.2 1.0 1.2
Noisy workplace 1.2 1.5 1.9 -1.4 1.4 -0.8
Qualifications: A levels/AS levels or equivalent 4.2 9.4 17.4 4.2 -3.2 -0.7
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 3.0 1.7 -0.8 0.5
Mouth/teeth dental problems: Dentures 0.2 0.4 0.6 0.8 -0.3 -0.8
Asthma 0.1 0.2 0.3 -0.6 0.5 -0.2
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 3.4 0.6 -0.1 1.8
Medication: Cholesterol lowering 0.2 0.4 1.0 1.0 0.0 0.2
Depression (self-reported) 2.8 3.4 4.5 1.7 1.7 2.1
Medication: Lansoprazole 0.1 0.1 0.3 0.2 0.5 0.3
Prospective memory result 0.8 1.0 1.9 0.7 1.4 0.9
Lung cancer (father) 0.3 0.3 1.0 -1.0 -0.1 0.1
Illnesses of mother 0.8 1.0 1.7 -1.2 -1.3 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 0.9 1.0 -0.5 0.9
Pulse wave Arterial Stiffness index 2.3 2.7 4.6 1.6 -2.1 -1.0
Impedance of arm (left) 0.6 2.6 7.7 -0.2 -2.8 -0.3
Arm fat mass (right) 0.1 0.4 1.0 -1.0 0.4 0.0
Trunk predicted mass 0.1 0.8 2.0 1.4 -0.5 0.3
Standing height 0.5 4.9 7.3 2.5 -2.7 -1.0
Length of working week for main job 1.2 1.3 1.7 -1.0 1.1 1.3
Exposure to tobacco smoke at home 1.0 1.1 3.2 -1.8 -0.5 0.1
Breastfed as a baby 1.8 2.2 4.1 2.0 -1.6 -0.2
Tense / ‘highly strung’ 0.4 0.6 1.9 0.2 -0.1 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.6 3.9 6.8 -0.1 2.6 2.2
Hair/balding pattern: Pattern 4 0.1 0.3 1.0 -0.0 -1.0 0.2
Birth weight of first child 0.2 0.5 0.8 -0.3 -0.9 0.7
Peak expiratory flow (PEF) 0.3 0.8 1.5 0.1 -1.2 1.0
Pulse wave reflection index 0.6 0.7 1.3 0.3 -1.1 -0.9
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.9 0.7 0.7 1.7
Loud music exposure frequency 0.2 0.2 0.3 -0.4 0.5 0.4
Qualifications: O levels/GCSEs or equivalent 1.7 2.8 5.1 2.3 -1.7 -0.4
Mouth/teeth dental problems: Bleeding gums 1.6 2.0 4.0 -1.5 -2.0 -0.0
Blood clot in the leg (DVT) 0.2 0.2 0.6 0.1 0.0 -0.8
Medication: Paracetamol 1.5 2.5 4.8 -0.7 1.5 2.2
Headache pain in last month 0.7 1.3 2.8 1.7 0.2 1.0
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 1.3 0.9 -1.1 -1.0
Glaucoma (self-reported) 0.1 0.2 0.4 -0.6 -0.1 -0.3
Gout (self-reported) 1.5 2.1 6.0 -2.4 -0.4 0.5
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 4.0 -0.3 -2.0 -0.2
Medication: Amlodipine 0.7 1.0 1.5 -1.2 1.2 0.2
Medication: Ventolin 100micrograms inhaler 1.4 1.8 3.1 -1.8 1.4 -0.3
Birth weight 0.3 0.7 1.6 1.3 -0.4 0.5
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.7 0.8 0.3 0.2
High blood pressure (siblings) 2.0 2.9 8.4 0.6 2.9 0.1
Forced vital capacity (FVC), Best measure 0.3 0.9 1.8 1.3 -1.0 0.3
Body fat percentage 0.2 0.6 1.9 -1.4 0.2 -0.1
Leg fat percentage (right) 0.2 0.6 1.5 -1.2 0.5 0.1
Arm fat-free mass (right) 0.0 0.2 0.3 0.6 0.2 0.3
Exposure to tobacco smoke outside home 0.7 0.9 1.3 -1.2 0.5 -1.1
Comparative body size at age 10 0.2 0.6 1.5 0.1 0.6 -1.2
Number of full brothers 0.5 0.6 1.7 -0.1 1.3 -0.3
Worry too long after embarrassment 0.8 1.3 2.3 -0.5 1.1 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.1 1.1 0.5 0.8
Wheeze or whistling in the chest in last year 0.5 1.0 1.3 -0.6 1.1 1.1
Number of children fathered 2.0 2.2 5.1 0.5 2.3 1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 2.1 -1.4 -1.1 -1.2
Age at first live birth 1.3 2.4 3.1 1.6 -1.8 -1.2
Pulse wave peak to peak time 1.9 2.2 3.9 -1.3 2.0 1.0
Health satisfaction 1.9 2.5 3.4 1.0 1.9 1.8
Shortness of breath walking on level ground 0.4 0.5 0.6 -0.7 0.6 0.8
Qualifications: College or University degree 0.9 2.8 4.3 2.1 -2.0 0.1
Eye problems/disorders: None of the above 0.7 0.8 1.3 -1.2 0.7 0.7
Mouth/teeth dental problems: Loose teeth 2.7 3.2 4.4 1.2 -2.0 -2.1
Emphysema/chronic bronchitis 0.7 0.8 2.1 -0.5 -0.4 -1.4
Medication for pain relief, constipation, heartburn 1.3 2.3 3.6 0.0 -1.8 -1.9
Neck or shoulder pain in last month 2.2 3.2 5.4 -1.4 2.3 1.4
Medication: Blood pressure 1.3 2.4 4.1 -1.1 2.0 1.3
Angina (self-reported) 0.7 0.9 1.6 -0.9 1.2 0.6
Migraine (self-reported) 0.5 0.7 1.5 0.7 -1.2 -0.1
Medication: Ibuprofen 1.6 1.9 3.6 1.2 -0.8 1.9
Medication: Allopurinol 1.1 1.5 3.9 -2.0 -0.7 0.0
Medication: Omeprazole 0.5 0.6 0.9 0.1 -0.9 -0.9
Medication: Seretide 50 evohaler 0.2 0.2 0.6 -0.1 0.8 -0.0
Mean time to correctly identify matches 2.1 4.0 6.7 1.5 -1.7 -2.6
Heart disease (mother) 1.4 1.7 3.8 -0.4 1.9 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.4 -1.1 0.0 1.5
Whole body fat mass 0.1 0.3 0.7 -0.8 0.3 0.1
Leg fat mass (right) 0.1 0.3 0.7 -0.8 0.6 0.2
Arm predicted mass (right) 0.0 0.2 0.3 0.6 0.3 0.3
Pulse rate, automated reading 0.1 0.3 0.5 0.7 -0.3 -0.3
Alcohol intake frequency. 0.1 0.3 0.5 -0.0 -0.5 -0.7
Comparative height size at age 10 0.7 4.0 5.2 2.2 -1.4 -2.3
Number of full sisters 1.4 1.7 2.5 -0.2 1.6 1.6
Suffer from ‘nerves’ 0.2 0.3 0.4 0.3 0.6 0.7
Overall health rating 2.9 6.2 14.7 -1.1 3.8 1.6
Chest pain or discomfort 0.9 1.3 2.5 -0.8 1.6 0.8
Had major operations 0.2 0.3 0.6 0.8 0.1 0.4
Age at last live birth 0.7 1.0 2.0 0.8 -1.4 -0.6
Family relationship satisfaction 0.8 1.0 2.2 1.5 0.0 0.9
Leg pain on walking 0.8 1.0 1.8 -1.0 0.2 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 1.4 -1.2 -1.1 -0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.6 0.7 -0.1 0.8
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 5.6 -0.8 -2.4 -0.0
Medication: Aspirin 0.8 1.1 1.4 1.0 1.2 0.9
Supplements: Vitamin C 0.4 0.5 1.2 -1.1 -0.2 0.4
Knee pain experienced in last month 2.8 4.3 5.7 -2.4 1.5 2.2
Hypertension (Self-reported) 1.1 3.0 7.2 -1.3 2.7 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.3 0.4 -0.5 0.2
Illnesses of father: Heart disease 1.2 1.7 2.7 -0.7 1.3 1.6
Illnesses of siblings: Diabetes 0.7 0.8 1.4 1.2 -0.5 -0.9
Smoking status: Previous 0.1 0.2 0.3 -0.1 0.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 2.7 1.6 -0.9 1.1
Whole body fat-free mass 0.1 0.3 0.9 0.9 -0.3 0.1
Leg fat-free mass (right) 0.0 0.0 0.1 0.3 -0.2 -0.2
Arm fat percentage (left) 0.2 1.0 2.7 -1.7 0.4 0.1
Average weekly red wine intake 0.3 0.4 1.0 -0.5 -1.0 0.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 0.8 -0.1 0.2
Mood swings 0.8 1.4 2.4 1.5 0.2 1.4
Loneliness, isolation 1.7 2.4 6.0 0.4 1.0 2.4
Long-standing illness, disability or infirmity 0.8 1.2 3.1 0.3 1.8 0.7
Ever had bowel cancer screening 0.1 0.2 0.2 0.4 0.5 -0.3
Diabetes diagnosed by doctor 1.3 2.2 2.7 -1.6 1.6 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 -0.5 -0.4 -0.3
Friendships satisfaction 0.7 0.8 1.5 1.2 -0.7 -0.7
Qualifications: nursing, teaching 4.0 6.3 11.2 3.3 -2.8 0.1
Commuting to job workplace: Walk 0.8 0.8 1.2 -1.1 0.4 -1.0
Eye problems/disorders: Cataract 0.5 0.5 1.6 1.3 0.1 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.6 -0.7 0.8 0.2
Medication for cholesterol 0.5 0.7 1.2 1.1 -0.9 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.4 -1.1 -0.2 -1.2
Back pain experienced in last month 2.8 4.1 10.8 -0.4 1.2 3.3
Mineral and other dietary supplements 0.1 0.1 0.4 -0.1 0.6 0.1
Breast cancer (self-reported) 1.5 1.8 4.2 -0.6 -1.0 -2.0
Asthma (self-reported) 0.1 0.2 0.4 -0.6 0.5 -0.1
Osteoporosis (self-reported) 1.1 1.3 2.9 -0.2 -1.0 -1.7
Osteoarthritis (self-reported) 0.1 0.2 0.3 0.4 -0.2 0.6
Medication: Aspirin 0.7 0.8 1.1 0.9 1.0 0.8
Medication: Gliclazide 1.6 1.8 2.0 -1.4 1.3 -1.3
Illnesses of father: None of the above (group 1) 0.3 0.4 0.5 -0.7 -0.7 -0.4
Smoking status: Current 4.3 6.8 14.1 0.9 3.8 2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.2 0.3 -0.1 -0.4
Whole body water mass 0.1 0.3 0.8 0.9 -0.3 0.0
Leg predicted mass (right) 0.0 0.1 0.1 0.3 -0.3 -0.2
Arm fat mass (left) 0.2 0.6 1.6 -1.3 0.5 0.2
Number of self-reported non-cancer illnesses 0.1 0.3 0.7 0.3 0.8 0.0
Average weekly champagne plus white wine intake 0.9 1.2 3.1 0.7 -1.8 -0.4
Miserableness 0.2 0.3 0.7 0.5 -0.1 0.8
Guilty feelings 0.8 1.3 2.5 -1.1 0.1 1.6
Wears glasses or contact lenses 0.2 0.2 0.3 0.4 0.5 0.4
Ever taken oral contraceptive pill 0.3 0.4 0.9 0.9 -0.4 -0.0
Hearing aid user 0.1 0.1 0.4 -0.2 0.6 0.1
Mother’s age at death 1.9 2.4 4.7 1.4 -2.2 -0.7
Financial situation satisfaction 3.0 3.7 6.4 0.3 2.5 2.1
Tinnitus: Yes, now most or all of the time 4.1 4.8 9.7 2.1 -3.1 -0.8
Commuting to job workplace: Public transport 1.4 1.7 4.4 0.7 -0.5 -2.1
Eye problems/disorders: Glaucoma 0.1 0.2 0.4 -0.0 -0.2 -0.7
Medication: Blood pressure 0.8 1.6 2.1 -1.4 1.1 -1.2
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.7 -0.1 -0.0 0.9
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.3 -0.2 -0.4 0.6
High cholesterol (Self-reported) 0.0 0.0 0.1 -0.3 -0.0 0.1
Medication: Bendroflumethiazide 1.2 1.8 3.7 -1.3 1.9 -0.1
Medication: Paracetamol 1.6 2.6 6.5 0.2 1.0 2.6
Medication: Lisinopril 1.7 2.2 6.4 -0.1 2.5 -0.4
Medication: Atorvastatin 0.6 0.8 1.2 0.3 1.1 1.0
Illnesses of father: High blood pressure 1.1 1.4 3.0 -0.9 1.7 0.6
Alcohol drinker status: Never 1.3 1.5 4.0 -0.4 -2.0 -0.6
Ever smoked 2.0 3.5 7.5 0.6 2.7 1.6
Basal metabolic rate 0.0 0.2 0.3 0.6 -0.3 0.1
Leg fat percentage (left) 0.2 0.7 1.3 -1.1 0.7 -0.5
Arm fat-free mass (left) 0.0 0.2 0.3 0.6 0.4 0.0
Number of operations (self-reported) 0.2 0.3 0.4 0.5 0.5 0.6
Average weekly beer plus cider intake 0.0 0.0 0.1 -0.3 0.1 -0.1
Irritability 2.4 4.1 6.0 2.5 -2.1 1.3
Risk taking 0.2 0.2 0.4 0.6 0.1 0.6
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.3 -0.4 1.5 -0.7
Fractured/broken bones in last 5 years 0.3 0.4 0.9 -0.9 0.4 0.2
Age started oral contraceptive pill 0.4 0.5 1.0 -0.1 -1.0 0.6
Diastolic blood pressure, automated reading 1.5 4.7 11.7 -1.5 3.4 0.1
Ever depressed for a whole week 2.7 3.3 3.9 -1.6 2.0 1.9
Unable to work because of sickness or disability 0.4 0.5 0.8 0.9 -0.8 0.2
Commuting to job workplace: Cycle 2.1 2.6 5.8 2.4 -0.4 1.3
Myopia 0.7 1.1 2.0 0.4 -1.4 -1.0
Vascular/heart problems diagnosed by doctor 1.5 4.1 9.0 1.4 -3.0 -1.1
Cholesterol lowering medication 1.1 1.6 2.8 -1.4 1.7 0.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.6 0.8 -0.4 -0.6
Pain experienced in last month 4.7 7.8 14.3 1.5 -2.6 -3.8
Supplements: Calcium 0.0 0.0 0.1 0.3 0.0 -0.2
Basal cell carcinoma (self-reported) 1.5 1.8 3.7 1.9 0.2 -1.2
Heart attack/myocardial infarction (self-reported) 1.3 1.6 2.8 -0.1 1.7 1.4
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.5 0.2 -0.1 -0.7
Heart disease (siblings) 0.6 0.8 2.0 -0.6 0.3 1.4
Alcohol drinker status: Previous 3.2 3.6 5.2 2.2 -2.3 -0.9
Pack years of smoking 0.4 0.6 1.7 0.3 -0.4 -1.3
Impedance of whole body 0.4 1.9 5.3 0.2 -2.3 -0.4
Leg fat mass (left) 0.1 0.4 0.6 -0.8 0.7 0.1
Arm predicted mass (left) 0.0 0.1 0.2 0.5 0.3 0.2