Hub : Genes

WDR62

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.056	0.0230	3.3e-03	0.016	0.027	0.019	0.023	0.015	4.1e-03	0.00028	1.8e-03	8e-04	5.7e-03
2	GTEx	Muscle Skeletal	0.179	0.0525	3.4e-04	0.051	NA	0.066	NA	0.048	8.9e-06	NA	5.1e-07	NA	1.6e-05
3	GTEx	Nerve Tibial	0.531	0.0600	4.1e-13	0.064	NA	0.282	NA	0.237	2.4e-05	NA	3.4e-20	NA	8.6e-17
4	GTEx	Skin Not Sun Exposed Suprapubic	0.355	0.0880	1.0e-04	0.069	NA	0.053	NA	0.128	1.2e-04	NA	7.2e-04	NA	1.8e-07
5	GTEx	Skin Sun Exposed Lower leg	0.354	0.0590	1.2e-10	0.076	NA	0.223	NA	0.181	6.7e-07	NA	2.4e-18	NA	7.5e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.1	1.7	4.8	0.5	-1.2	1.1	-2.2	0.8
Bipolar Disorder or Schizophrenia	1.5	3.7	13.5	-0.2	0.4	2.2	-3.7	-0.3
Depressed Affect (Nagel 2018)	0.2	0.5	1.1	1.1	0.2	0.4	0.4	-1.0
Depression (Nagel 2018)	0.6	0.9	3.1	1.8	0.2	-0.3	-0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.0	0.9	-0.6	1.4	0.2	1.0
Neuroticism (Nagel 2018)	0.5	1.2	2.7	-0.2	1.0	0.7	-1.4	-1.6
Schizophrenia (2018)	1.5	3.2	8.3	-0.6	1.5	2.0	-2.9	-1.0
Schizophrenia vs Biploar Disorder	0.7	0.9	3.3	-0.5	0.0	-1.8	0.9	0.5
Worry (Nagel 2018)	0.9	1.9	3.8	-1.1	1.0	0.8	-1.8	-1.9
Alzheimer’s Disease (in mother)	2.7	3.2	12.2	-0.6	1.5	0.3	-3.5	-1.0
Alzheimer’s Disease (in father)	0.5	0.6	0.7	0.6	0.8	0.9	0.8	-0.7
Alzheimer’s Disease (including proxy)	2.2	3.3	6.2	-0.7	2.5	1.4	-2.0	-1.9
Crohns Disease (2017)	0.9	1.9	3.5	-0.6	1.9	-1.3	-1.4	-1.3
Irritable Bowel Disease (IBD)	1.3	3.0	4.8	-1.2	2.2	-1.8	-0.8	-2.2
Ulcerative Colitis (UC)	1.0	1.8	3.8	-0.9	1.6	-1.4	0.3	-1.9
Major Depression (MDD)	3.3	4.0	11.4	1.2	-1.4	-2.2	-3.4	0.7
Reaction Time	0.9	1.8	4.5	1.2	-1.1	1.3	-2.1	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	0.2	0.5	0.4	0.5	-0.1
Breast Cancer	0.6	1.3	2.9	1.6	-0.6	-0.5	1.7	0.9
Ovarian Cancer	1.6	2.1	5.3	2.0	0.5	2.3	0.9	0.5
Prostate Cancer	0.7	1.0	2.5	-1.6	0.1	0.9	1.1	-0.7
Age at First Birth	0.5	0.8	2.2	-1.1	-0.2	-1.5	0.1	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.5	0.6	-0.3	-1.2	-0.7	-0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.4	-0.0	-0.2	-0.6	0.1	-0.2
Crohns Disease (2012)	1.6	2.5	11.0	-0.8	0.1	-0.7	-3.3	-0.7
Mean Putamen Volume	2.7	3.1	7.2	2.7	-2.3	0.5	-0.1	1.7
Fasting Glucose	0.4	0.5	1.1	1.0	0.1	1.0	0.6	0.2
HbA1C	0.4	0.5	1.3	0.1	0.2	1.1	0.9	0.5
HDL Cholesterol	0.3	0.5	0.9	-0.7	-0.9	-0.4	-0.9	0.2
LDL Cholesterol	0.3	0.4	1.0	0.5	0.6	-0.3	1.0	-0.8
Lupus	0.1	0.2	0.9	-0.2	-0.1	0.9	0.3	-0.3
Neuroticism (2016)	0.3	0.4	1.3	1.1	-0.6	-0.2	0.3	-0.2
Primary Biliary Cirrhosis	0.4	0.6	2.0	-0.7	0.2	0.7	-0.3	-1.4
Rheumatoid Arthritis	0.3	0.4	1.6	0.3	-0.5	0.2	1.2	-0.1
Schizophrenia (2014)	0.7	1.7	7.5	-0.7	0.2	0.3	-2.7	-0.4
Triglycerides	0.7	1.2	3.0	1.7	-0.9	-0.8	1.3	0.3
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.9	0.8	-1.6	-0.1	-1.7	0.9
Ulcerative Colitis	1.2	1.8	3.9	-1.6	1.6	-0.0	-0.1	-2.0
Blood Eosinophil Count	0.4	2.7	10.1	0.5	-1.0	1.5	-3.2	0.4
Blood Platelet Count	0.3	3.5	9.9	-0.2	-2.2	-1.2	-3.1	0.9
Blood Red Count	0.3	3.3	5.3	2.3	-1.0	-1.2	1.9	2.2
Blood White Count	0.1	0.4	1.0	-0.8	0.6	-0.2	0.0	-1.0
Heel T-Score	0.2	1.3	3.3	-0.3	-0.6	-1.6	-1.8	-0.1
BMI	1.0	5.9	12.9	3.6	-2.2	0.6	0.1	3.3
Height	0.6	11.3	23.1	-2.9	4.8	3.3	0.7	-3.7
Waist Hip Ratio (WHR)	0.3	1.4	2.0	0.7	0.9	1.3	1.4	-1.4
Systolic Blood Pressure	0.5	2.4	7.1	-1.3	1.1	0.8	-2.7	-1.2
Smoking Status	0.3	0.6	2.5	0.2	1.6	0.7	0.1	-0.1
Allergy or Eczema	0.2	0.6	2.7	-0.3	0.3	1.6	0.1	-0.5
Cardiovascular Disease	0.3	0.9	2.2	-0.7	0.0	-0.8	-1.5	-1.1
Hypothyroidism (self reported)	0.8	1.8	4.0	0.0	-1.4	-1.8	-2.0	-0.0
Respiratory disease	1.1	2.4	8.1	-1.4	0.5	0.4	-2.8	-1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	1.0	0.3	0.8	-0.5	-0.4
Lung FEV1/FVC ratio	0.3	1.7	5.2	2.3	-0.0	-0.4	1.5	0.9
Lung FVC	1.1	5.4	10.4	-3.2	1.8	-3.0	1.8	-1.2
Neuroticism	0.2	0.6	1.4	-0.1	-0.2	-0.2	-1.1	-1.2
Chronotype (morning person)	0.2	0.4	1.5	-0.7	-0.1	0.2	0.2	1.2
Hair Pigment	0.0	0.5	1.7	0.3	-0.5	0.2	0.8	1.3
Tanning	0.4	4.3	9.9	0.0	-2.8	-3.1	-1.8	0.8
Hand grip strength (left)	0.5	1.4	3.5	-0.9	1.9	0.7	1.4	0.3
Number of treatments/medications taken	0.7	1.3	3.0	1.3	0.8	0.1	-1.7	-1.0
Average weekly spirits intake	1.7	2.1	6.5	-0.1	-1.8	0.0	-2.6	0.9
Sensitivity / hurt feelings	0.7	1.2	5.9	-0.1	0.4	2.4	-0.2	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.0	1.4	0.1	-0.2	-0.7	-0.4
Hearing difficulty/problems: Yes	1.2	1.8	4.5	1.8	0.5	0.9	2.1	0.5
Relative age of first facial hair	0.5	1.0	2.9	-0.8	1.7	-0.3	1.2	-0.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	1.0	0.2	1.3	-1.4	-0.1
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.9	-0.6	-0.2	-0.8	-2.2	-1.5
Ever had hysterectomy (womb removed)	0.4	0.5	1.9	0.7	-0.1	1.4	-0.1	-0.1
Systolic blood pressure, automated reading	0.5	1.6	3.3	-0.6	1.5	1.3	-1.8	-0.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.9	0.2	0.7	1.4	-0.6	-1.7
Angina	0.9	1.2	2.4	-0.4	-1.5	-1.0	1.5	0.5
Medication for hormone replacement therapy	2.1	2.4	5.3	-0.6	1.7	0.1	-1.8	-2.3
Vitamin and mineral supplements	0.5	0.6	2.1	0.6	-0.5	0.5	1.5	-0.2
Supplements: Zinc	0.3	0.3	1.2	-0.3	0.4	0.0	-1.1	-0.3
Medication: Co-codamol	1.0	1.2	1.8	0.8	-1.3	-0.5	-1.3	1.2
Medication: Metformin	0.4	0.6	1.7	0.3	0.4	1.3	-0.9	-0.0
Diabetes (father)	0.4	0.5	1.4	0.8	-0.4	1.2	0.2	0.3
Diabetes (mother)	0.2	0.3	0.7	0.4	0.1	0.0	-0.8	0.6
Severe depression (siblings)	1.6	1.8	6.0	-0.0	1.2	0.1	-2.4	-1.2
Pack years adult smoking proportion	0.1	0.1	0.4	0.4	-0.4	-0.1	0.1	0.6
Impedance of leg (right)	0.4	1.9	6.4	-0.3	-0.7	-2.5	-1.0	-1.2
Leg fat-free mass (left)	0.4	2.1	6.8	1.4	0.3	2.6	0.4	1.3
Trunk fat percentage	1.3	5.1	12.2	3.5	-2.1	0.3	-0.9	2.8
Hand grip strength (right)	0.7	1.9	3.3	-1.6	1.6	1.1	1.8	0.0
Townsend deprivation index at recruitment	0.8	1.1	4.3	-0.3	-0.5	0.6	-2.1	0.5
Current tobacco smoking	0.2	0.3	0.5	0.7	0.4	0.6	-0.6	0.2
Average weekly fortified wine intake	0.8	0.9	3.0	-1.7	0.4	-0.4	-0.7	-0.9
Maternal smoking around birth	2.5	3.6	12.0	3.5	-0.6	1.1	-0.4	2.1
Fed-up feelings	0.3	0.6	2.8	0.4	-0.4	-1.7	-0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.8	1.9	-0.5	-0.5	-0.5	-0.2
Relative age voice broke	1.5	2.2	5.8	-1.3	1.5	-2.4	0.9	-0.7
Taking other prescription medications	0.3	0.5	0.9	0.9	0.1	-0.4	-0.8	-1.0
Age when periods started (menarche)	0.9	2.2	8.8	0.5	3.0	-0.4	0.5	-1.1
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	11.7	0.0	-1.0	-0.9	-3.4	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.9	-0.8	-0.9	-0.5	-2.0	0.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	4.5	2.1	-0.3	-1.2	0.5	0.6
Qualifications: CSEs or equivalent	0.6	0.8	1.8	1.3	0.2	1.4	0.1	0.8
Serious illness, injury or assault to yourself	0.9	1.1	3.3	1.8	0.0	1.2	-0.8	0.3
High blood pressure	0.3	0.8	3.3	-0.8	-0.0	-1.8	-0.2	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.0	-1.0	-0.2	0.7	-0.3	-0.7
Multivitamins +/- minerals	0.5	0.6	2.3	0.2	-0.0	0.8	-1.5	0.4
Stomach or abdominal pain in last month	0.6	0.7	1.5	1.0	-0.8	-0.8	-1.2	0.2
Supplements: Glucosamine	0.4	0.5	0.9	-0.5	-0.7	0.2	-0.8	1.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.2	0.4	-0.1	-1.8	-0.8	0.2
Medication: Atenolol	0.5	0.6	2.5	0.1	-0.2	-0.6	1.6	0.0
Medication: Levothyroxine sodium	0.2	0.4	1.5	0.5	-1.2	-0.3	-0.4	0.0
Sitting height	0.1	0.9	1.3	-1.1	1.0	-1.1	0.5	-1.1
Chronic bronchitis/emphysema (father)	1.3	1.5	3.6	0.6	0.6	1.9	1.6	0.9
High blood pressure (mother)	1.5	2.0	6.8	1.7	0.2	-0.4	-2.6	0.5
Body mass index (BMI)	1.1	4.9	10.3	3.2	-1.5	1.7	-1.3	2.7
Impedance of leg (left)	0.6	2.7	9.5	-1.0	-0.3	-3.1	-1.1	-1.3
Leg predicted mass (left)	0.4	2.3	7.1	1.5	0.3	2.7	0.5	1.4
Trunk fat mass	1.0	4.3	10.9	3.3	-1.6	1.1	-0.7	2.6
Waist circumference	1.1	4.0	12.1	3.5	-0.4	2.2	-0.5	1.6
Number of incorrect matches in round	2.1	3.6	7.1	-2.7	0.5	0.4	-2.1	-2.5
Past tobacco smoking	0.6	1.1	2.0	-0.7	-1.3	-0.7	-0.9	-1.4
Alcohol usually taken with meals	0.6	0.9	2.8	0.3	0.2	1.7	1.1	0.7
Nervous feelings	0.6	1.0	3.7	-1.0	0.0	0.4	-1.9	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.9	1.7	0.1	0.5	1.1	0.1
Hearing difficulty/problems with background noise	1.4	2.2	7.3	-0.0	1.6	1.1	2.7	-0.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.5	-0.3	0.8	-0.5	-0.3
Had menopause	1.1	1.3	2.5	-1.1	0.8	0.0	-1.5	-1.6
Had other major operations	1.6	2.0	8.1	2.8	-0.3	1.1	-0.6	0.1
Forced vital capacity (FVC)	0.7	2.6	7.2	-2.7	1.1	-1.0	1.9	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.7	0.6	-1.3	0.1	-2.2	1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	0.9	0.7	0.3	-0.5	-0.6
Qualifications: None of the above	0.2	0.4	1.7	-0.3	0.3	-1.3	-0.3	-0.5
Financial difficulties in last 2 years	2.3	3.0	8.5	2.9	-1.1	0.9	-1.0	1.9
Mouth/teeth dental problems	0.4	0.6	2.6	0.3	-1.6	0.5	-0.4	0.2
Heart attack	0.5	0.6	1.9	0.9	-0.4	-1.4	0.5	0.4
Allergy	0.6	1.3	2.4	1.4	-0.9	-0.9	0.8	1.6
Pain all over the body in last month	1.1	1.2	2.9	0.9	-1.4	-0.2	0.4	1.7
Diabetes (self-reported)	0.1	0.1	0.4	0.3	0.2	0.1	-0.6	-0.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.9	0.0	1.0	0.7	-1.7	-1.2
Medication: Ramipril	0.5	0.7	2.7	0.1	0.4	-1.6	0.1	-0.7
Medication: Simvastatin	0.1	0.2	0.5	0.7	-0.5	-0.1	0.4	0.2
Fluid intelligence score	0.2	0.5	1.1	0.3	0.9	1.0	0.4	0.4
Illnesses of siblings	1.5	2.1	5.3	-1.0	1.7	2.3	1.2	-0.3
Neuroticism score	0.2	0.4	0.9	-0.0	-0.5	0.1	-1.0	-0.9
Weight	0.7	3.4	7.2	2.7	-0.4	2.4	-0.6	1.9
Impedance of arm (right)	0.2	1.0	3.2	-0.1	-0.4	-1.8	0.7	-1.0
Arm fat percentage (right)	1.4	5.5	13.6	3.7	-1.9	1.3	-1.0	2.7
Trunk fat-free mass	0.4	2.0	7.6	0.1	1.6	2.8	-0.1	-0.2
Hip circumference	0.7	3.0	7.1	2.7	-0.3	1.8	-1.5	1.4
Time employed in main current job	0.9	1.0	3.3	-1.0	1.8	0.5	0.3	-0.6
Alcohol intake versus 10 years previously	0.8	1.1	3.6	0.5	-1.3	-0.3	-1.9	-0.2
Father’s age at death	0.7	0.9	2.5	-1.6	0.5	0.4	1.0	-0.7
Worrier / anxious feelings	2.5	4.6	9.6	-3.1	2.2	0.1	-0.7	-2.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.0	2.0	-1.6	-0.1	-0.7	0.7
Falls in the last year	1.2	1.6	3.2	1.8	-0.6	0.9	0.9	1.6
Hair/balding pattern: Pattern 3	0.7	1.1	4.4	0.6	0.8	0.4	2.1	0.0
Number of live births	2.3	3.2	9.9	3.1	-2.1	-0.2	-0.7	1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.3	-1.2	0.8	-1.0	1.5	-0.1
Pulse rate	3.7	6.2	13.0	1.3	-3.6	-0.8	1.9	3.5
Happiness	0.6	0.8	2.6	0.3	0.2	1.1	-1.6	0.0
Noisy workplace	0.7	0.9	2.4	-0.2	1.2	-1.6	-0.2	0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.5	0.6	0.4	-0.0	1.9	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.2	0.8	-0.8	-0.8	0.3	1.8
Mouth/teeth dental problems: Dentures	0.5	0.8	2.2	-0.4	1.5	0.1	-1.0	-0.9
Asthma	1.1	2.1	3.8	-1.9	0.6	1.1	-1.8	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	1.1	-0.3	0.8	0.4	0.4
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.1	-0.4	-0.5	0.6	0.1
Depression (self-reported)	1.2	1.4	5.5	0.9	-0.8	0.0	-2.3	0.4
Medication: Lansoprazole	1.0	1.1	1.8	1.3	-1.0	-1.1	-1.2	0.4
Prospective memory result	4.7	5.8	13.5	-3.7	1.1	-0.8	-2.7	-2.5
Lung cancer (father)	0.4	0.4	1.3	0.3	-0.6	-0.4	-1.1	0.5
Illnesses of mother	0.8	1.0	1.8	-0.4	-1.4	1.0	1.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.7	-1.2	1.2	-1.4	1.6	-0.3
Pulse wave Arterial Stiffness index	1.2	1.4	2.6	1.0	-0.2	1.6	1.6	0.8
Impedance of arm (left)	0.4	1.8	6.9	-0.4	-0.7	-2.6	0.8	-1.0
Arm fat mass (right)	1.1	4.5	10.6	3.3	-1.5	1.4	-1.1	2.5
Trunk predicted mass	0.3	2.0	7.5	0.2	1.5	2.7	-0.2	-0.1
Standing height	0.2	2.3	4.5	-1.0	2.1	1.5	1.2	-1.4
Length of working week for main job	4.0	4.4	10.7	3.3	-2.4	-0.6	0.5	2.2
Exposure to tobacco smoke at home	1.3	1.5	2.7	0.3	-1.6	-1.6	0.3	1.4
Breastfed as a baby	1.4	1.8	2.7	-1.6	1.5	0.8	-1.5	-1.1
Tense / ‘highly strung’	0.8	1.3	5.0	-1.0	-0.2	0.2	-2.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	1.2	0.8	0.5	-0.3	-0.0
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	-1.1	0.2	-0.5	-0.3	-0.6
Birth weight of first child	0.9	1.6	2.7	-0.6	1.6	1.5	-1.6	-0.2
Peak expiratory flow (PEF)	0.2	0.4	1.3	-0.2	0.5	-0.0	1.1	0.7
Pulse wave reflection index	1.3	1.7	3.9	0.3	1.6	2.0	0.5	-1.2
Ever highly irritable/argumentative for 2 days	2.1	2.5	9.5	3.1	-0.4	1.1	-0.4	1.2
Loud music exposure frequency	0.8	0.8	2.7	0.4	0.7	1.6	0.9	0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.8	0.4	0.0	1.4	1.3	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	-0.6	-0.1	0.0	1.1	0.8
Blood clot in the leg (DVT)	0.4	0.5	1.0	0.3	0.7	0.7	-0.7	-1.0
Medication: Paracetamol	1.1	1.8	3.0	1.7	1.6	1.0	1.4	0.5
Headache pain in last month	0.3	0.6	1.3	0.7	1.1	0.0	-0.3	-1.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	-0.2	-0.6	-0.3	-0.9	-0.0
Glaucoma (self-reported)	1.6	1.9	3.1	1.8	-1.3	0.1	1.7	1.2
Gout (self-reported)	0.7	1.0	2.1	-1.4	-0.6	-0.6	-1.4	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.9	0.8	-1.0	-0.6	-0.6	0.0
Medication: Amlodipine	0.5	0.7	2.5	-0.4	0.9	-0.2	0.4	-1.6
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.4	-1.1	1.0	1.6	-0.9	-1.5
Birth weight	0.2	0.4	1.3	-0.3	1.1	0.3	0.5	-0.7
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.2	2.3	-0.3	1.1	-0.9	0.5
High blood pressure (siblings)	1.3	1.8	3.4	1.3	-1.1	-1.6	-1.8	0.7
Forced vital capacity (FVC), Best measure	0.8	2.9	4.9	-2.2	1.6	-1.5	2.0	-0.7
Body fat percentage	1.4	5.4	12.5	3.5	-2.2	0.6	-1.3	2.8
Leg fat percentage (right)	1.5	5.5	14.0	3.7	-2.1	0.8	-1.0	2.7
Arm fat-free mass (right)	0.2	1.1	3.2	0.8	0.5	1.8	-0.8	1.0
Exposure to tobacco smoke outside home	0.7	0.9	2.0	0.7	1.4	1.1	0.5	0.7
Comparative body size at age 10	0.4	1.0	4.2	0.4	-0.4	-2.0	-0.4	-0.7
Number of full brothers	0.8	1.0	3.0	0.4	0.2	-1.2	-1.7	-0.3
Worry too long after embarrassment	0.8	1.3	3.2	-0.3	-1.7	-0.3	-1.8	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.0	-0.3	0.3	1.4	-0.6	-1.1
Wheeze or whistling in the chest in last year	0.7	1.2	3.0	1.2	1.0	0.7	-1.7	0.3
Number of children fathered	3.0	3.4	6.8	2.6	-2.1	-0.1	-0.5	2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.5	-1.2	-1.2	-0.4	-1.2	-0.2
Age at first live birth	0.9	1.6	3.9	-1.0	2.0	-0.2	1.3	-1.2
Pulse wave peak to peak time	1.3	1.5	2.8	-1.1	0.2	-1.6	-1.7	-0.9
Health satisfaction	0.5	0.7	1.7	0.8	1.3	1.0	-0.3	-0.2
Shortness of breath walking on level ground	0.5	0.6	2.4	0.3	1.6	0.3	-0.5	-0.1
Qualifications: College or University degree	0.5	1.4	2.4	-1.4	1.6	1.0	1.2	-0.7
Eye problems/disorders: None of the above	0.6	0.6	1.6	0.2	-1.3	-0.5	0.7	0.9
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.9	1.4	-1.4	-0.5	-0.9	1.3
Emphysema/chronic bronchitis	0.9	1.0	2.0	1.3	1.4	1.0	0.1	0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	3.2	-1.8	-0.1	0.5	-0.6	0.0
Neck or shoulder pain in last month	0.1	0.2	0.3	0.4	-0.2	-0.5	0.3	0.6
Medication: Blood pressure	0.3	0.6	1.1	-0.1	0.9	0.8	1.1	-0.5
Angina (self-reported)	1.0	1.4	2.7	-0.2	-1.6	-1.0	1.6	0.8
Migraine (self-reported)	0.9	1.1	3.8	-0.4	-1.0	-0.4	-1.9	-0.4
Medication: Ibuprofen	0.4	0.5	1.6	0.7	-0.3	1.3	-0.2	0.4
Medication: Allopurinol	0.8	1.0	2.0	-1.2	-0.8	-1.4	-1.0	0.2
Medication: Omeprazole	0.6	0.7	1.2	0.8	-1.1	-1.0	-0.7	0.5
Medication: Seretide 50 evohaler	2.5	2.9	5.5	-2.4	2.0	1.6	0.0	-1.4
Mean time to correctly identify matches	0.9	1.7	5.7	1.1	-1.2	0.6	-2.4	-0.3
Heart disease (mother)	0.8	1.0	3.1	-0.1	0.9	-1.8	0.9	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	-0.9	0.3	0.2	-0.5	-0.5
Whole body fat mass	1.0	4.2	9.6	3.1	-1.8	0.9	-0.9	2.6
Leg fat mass (right)	1.4	5.4	12.7	3.6	-1.8	1.4	-0.7	2.9
Arm predicted mass (right)	0.2	0.9	3.0	0.8	0.5	1.7	-0.5	0.8
Pulse rate, automated reading	6.2	20.0	38.5	4.8	-5.1	-1.4	3.4	6.2
Alcohol intake frequency.	1.0	2.4	5.7	1.1	-1.9	-0.6	-2.4	1.0
Comparative height size at age 10	0.3	1.8	7.2	0.4	0.6	2.7	-0.1	-1.1
Number of full sisters	0.7	0.9	3.6	1.9	-0.2	0.7	-0.4	-0.4
Suffer from ‘nerves’	0.6	1.0	3.1	1.1	-0.7	-0.1	-1.8	-0.3
Overall health rating	0.9	1.9	5.7	2.4	-1.1	-1.1	-0.2	1.2
Chest pain or discomfort	0.5	0.7	1.9	1.0	0.3	0.2	1.4	0.6
Had major operations	0.2	0.3	0.5	0.4	0.4	-0.5	-0.7	0.6
Age at last live birth	0.7	1.1	2.3	-0.5	1.5	0.3	1.2	-1.2
Family relationship satisfaction	0.9	1.2	3.8	-0.1	1.1	0.5	-1.9	-0.7
Leg pain on walking	1.3	1.6	4.5	-0.8	0.6	0.4	-2.1	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.7	1.2	-0.5	-0.7	-0.7	1.7
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.0	2.0	-0.2	1.6	0.6	1.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	4.8	-2.2	0.9	-1.0	0.8	-1.8
Medication: Aspirin	0.2	0.3	1.2	0.1	-0.6	-1.1	0.3	-0.1
Supplements: Vitamin C	1.2	1.4	5.2	-0.7	0.9	-2.3	0.3	-0.7
Knee pain experienced in last month	1.7	2.7	6.2	2.5	-1.3	1.1	1.1	1.8
Hypertension (Self-reported)	0.2	0.5	1.5	-0.7	-0.1	-1.2	-0.5	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.1	0.6	0.4	-1.4	0.5	-1.2
Illnesses of father: Heart disease	1.2	1.6	3.8	-0.3	-2.0	-0.6	-1.8	0.8
Illnesses of siblings: Diabetes	0.5	0.6	1.9	1.4	0.7	0.4	-0.5	0.3
Smoking status: Previous	0.5	0.7	2.0	-0.0	1.4	0.7	0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.2	-0.8	1.1	0.7	-0.3	-0.5
Whole body fat-free mass	0.3	1.9	7.3	0.7	1.1	2.7	0.1	0.6
Leg fat-free mass (right)	0.4	1.9	6.3	1.0	0.8	2.5	0.6	1.2
Arm fat percentage (left)	1.4	5.6	13.8	3.7	-2.2	0.8	-1.0	2.8
Average weekly red wine intake	1.8	2.6	8.1	0.6	-1.5	-1.2	-1.1	2.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	0.7	0.4	1.3	-0.4	-0.7
Mood swings	0.5	1.0	3.0	1.7	-0.2	1.2	0.3	-0.4
Loneliness, isolation	1.2	1.7	6.4	-0.0	-1.0	-2.5	-0.9	-0.6
Long-standing illness, disability or infirmity	0.2	0.2	0.9	1.0	0.1	-0.0	-0.5	0.2
Ever had bowel cancer screening	0.3	0.4	0.8	0.2	-0.9	-0.7	-0.2	0.7
Diabetes diagnosed by doctor	0.3	0.5	1.0	0.7	0.6	0.9	-1.0	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.5	1.2	-0.0	0.7	-1.0	0.3
Friendships satisfaction	1.2	1.5	5.3	1.2	-0.6	0.1	-2.3	-0.5
Qualifications: nursing, teaching	0.8	1.3	4.1	1.2	-0.4	2.0	0.9	0.1
Commuting to job workplace: Walk	1.6	1.7	3.6	-1.9	-0.7	-1.3	-1.3	-1.1
Eye problems/disorders: Cataract	0.8	0.9	1.9	0.2	1.0	0.7	-1.4	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	0.7	1.1	-0.7	1.4	-0.4
Medication for cholesterol	1.1	1.6	5.4	-0.1	0.7	2.3	1.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.8	1.4	0.0	-1.0	0.0	0.1
Back pain experienced in last month	0.9	1.2	4.9	1.0	-0.1	0.3	-2.2	-0.5
Mineral and other dietary supplements	0.8	1.1	2.8	1.0	1.3	0.2	1.7	-0.4
Breast cancer (self-reported)	0.6	0.7	2.2	0.5	-0.1	-0.6	1.5	0.9
Asthma (self-reported)	0.9	1.8	3.5	-1.5	0.5	1.2	-1.9	-1.2
Osteoporosis (self-reported)	0.5	0.6	1.4	1.2	0.3	0.9	0.6	-0.3
Osteoarthritis (self-reported)	0.3	0.3	1.5	1.2	-0.4	0.1	0.1	0.2
Medication: Aspirin	0.2	0.3	1.1	0.2	-0.6	-1.0	0.2	0.0
Medication: Gliclazide	1.2	1.4	3.1	1.7	0.5	1.8	0.0	0.8
Illnesses of father: None of the above (group 1)	0.5	0.7	1.4	0.7	1.2	0.3	1.1	-0.1
Smoking status: Current	0.2	0.3	0.8	0.9	0.2	0.5	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	3.0	-1.1	0.3	-1.7	1.6	0.3
Whole body water mass	0.3	1.6	6.5	0.7	0.9	2.5	-0.0	0.6
Leg predicted mass (right)	0.3	1.8	5.5	1.0	0.7	2.3	0.7	1.2
Arm fat mass (left)	1.1	4.5	10.3	3.2	-1.6	1.2	-1.0	2.7
Number of self-reported non-cancer illnesses	1.2	2.0	3.8	-0.3	0.4	-1.8	-1.9	-1.7
Average weekly champagne plus white wine intake	0.5	0.6	2.2	-0.5	0.6	-0.5	1.5	0.3
Miserableness	0.3	0.5	1.4	0.2	0.4	0.7	0.3	-1.2
Guilty feelings	0.3	0.4	1.6	0.2	-0.6	0.1	-1.3	0.4
Wears glasses or contact lenses	0.5	0.6	1.4	-0.2	1.2	-0.2	-0.3	-1.1
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.2	0.0	0.6	-0.4	0.7
Hearing aid user	0.2	0.2	0.4	-0.2	0.5	-0.6	-0.4	0.6
Mother’s age at death	1.5	1.9	5.2	-2.3	0.3	-0.9	1.3	-1.3
Financial situation satisfaction	0.9	1.2	2.3	1.4	-0.5	1.5	1.1	0.3
Tinnitus: Yes, now most or all of the time	2.0	2.3	7.3	-0.7	1.9	0.3	2.7	-0.5
Commuting to job workplace: Public transport	1.2	1.4	2.7	-0.7	1.4	0.5	1.6	-1.2
Eye problems/disorders: Glaucoma	1.4	1.7	2.3	1.2	-1.5	-0.8	1.5	1.2
Medication: Blood pressure	0.4	0.8	3.5	-0.3	-0.4	-1.9	-0.3	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.2	1.1	-0.7	0.6	-0.5	0.9
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.9	-1.4	-1.1	-0.9	-2.0	-0.2
High cholesterol (Self-reported)	0.7	1.2	2.1	-1.2	-1.4	-1.2	-0.9	-0.2
Medication: Bendroflumethiazide	0.6	0.9	2.6	-1.6	0.6	-0.8	0.3	-0.9
Medication: Paracetamol	0.7	1.1	3.0	1.7	1.2	0.7	0.4	0.2
Medication: Lisinopril	0.5	0.7	2.2	0.8	-1.5	-0.5	-0.5	0.4
Medication: Atorvastatin	1.5	1.9	5.2	-1.1	-1.4	-0.6	-2.3	0.8
Illnesses of father: High blood pressure	1.7	2.1	3.1	-1.8	0.7	-1.6	-1.7	-1.3
Alcohol drinker status: Never	1.4	1.7	7.8	0.1	-0.2	0.7	-2.8	-0.0
Ever smoked	0.4	0.7	1.7	0.5	0.9	0.8	0.5	1.3
Basal metabolic rate	0.3	1.9	6.6	1.2	0.7	2.6	-0.2	0.9
Leg fat percentage (left)	1.2	4.2	10.3	3.2	-1.7	0.7	-1.2	2.5
Arm fat-free mass (left)	0.3	1.6	5.3	1.1	0.8	2.3	-0.6	0.6
Number of operations (self-reported)	1.0	1.5	4.4	1.4	-0.7	-0.2	-2.1	0.8
Average weekly beer plus cider intake	1.1	1.7	4.3	-2.1	1.1	-0.6	-0.3	-1.5
Irritability	0.6	1.0	2.9	-0.9	0.9	0.1	-0.7	-1.7
Risk taking	0.5	0.7	1.8	0.7	-0.4	-0.9	-1.4	0.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	1.2	-0.9	0.1	0.7	0.8
Fractured/broken bones in last 5 years	1.7	2.2	5.2	0.8	-2.3	-1.7	0.7	1.2
Age started oral contraceptive pill	0.3	0.3	0.7	-0.8	0.1	-0.7	0.1	-0.6
Diastolic blood pressure, automated reading	1.6	5.1	12.6	3.0	-1.7	0.9	-0.5	3.6
Ever depressed for a whole week	0.5	0.7	1.3	1.1	0.4	0.3	-1.1	-0.8
Unable to work because of sickness or disability	0.7	0.9	2.3	0.3	0.8	1.5	-0.9	0.7
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.5	0.4	1.3	0.0	-1.0
Myopia	0.2	0.4	0.9	0.3	-0.1	1.0	-0.7	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.7	3.1	0.5	0.2	1.8	-0.6	0.2
Cholesterol lowering medication	1.0	1.5	4.2	-0.8	-1.3	-1.0	-2.1	0.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.5	0.7	-1.5	-1.6	-1.2	0.3
Pain experienced in last month	0.2	0.4	0.8	-0.9	-0.1	-0.0	-0.6	-0.8
Supplements: Calcium	0.3	0.4	1.1	0.3	-0.6	0.6	-1.0	0.1
Basal cell carcinoma (self-reported)	0.5	0.7	1.3	0.8	-1.1	-0.3	-0.2	1.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.7	0.6	-0.4	-1.3	0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.0	0.2	0.9	0.5	-0.7	-1.4
Heart disease (siblings)	1.2	1.5	4.0	-0.0	-1.8	-2.0	-0.2	0.2
Alcohol drinker status: Previous	1.0	1.1	4.0	2.0	-1.1	-0.0	-0.2	0.7
Pack years of smoking	0.2	0.4	0.6	0.8	-0.7	-0.3	0.1	0.7
Impedance of whole body	0.3	1.8	7.0	-0.5	-0.3	-2.6	0.0	-1.2
Leg fat mass (left)	1.2	4.6	10.7	3.3	-1.6	1.3	-0.8	2.7
Arm predicted mass (left)	0.3	1.4	4.3	1.0	0.7	2.1	-0.8	0.7