Hub : Genes

WDR62

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.056 0.0230 3.3e-03 0.016 0.027 0.019 0.023 0.015 4.1e-03 0.00028 1.8e-03 8e-04 5.7e-03
2 GTEx Muscle Skeletal 0.179 0.0525 3.4e-04 0.051 NA 0.066 NA 0.048 8.9e-06 NA 5.1e-07 NA 1.6e-05
3 GTEx Nerve Tibial 0.531 0.0600 4.1e-13 0.064 NA 0.282 NA 0.237 2.4e-05 NA 3.4e-20 NA 8.6e-17
4 GTEx Skin Not Sun Exposed Suprapubic 0.355 0.0880 1.0e-04 0.069 NA 0.053 NA 0.128 1.2e-04 NA 7.2e-04 NA 1.8e-07
5 GTEx Skin Sun Exposed Lower leg 0.354 0.0590 1.2e-10 0.076 NA 0.223 NA 0.181 6.7e-07 NA 2.4e-18 NA 7.5e-15

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.1 1.7 4.8 0.5 -1.2 1.1 -2.2 0.8
Bipolar Disorder or Schizophrenia 1.5 3.7 13.5 -0.2 0.4 2.2 -3.7 -0.3
Depressed Affect (Nagel 2018) 0.2 0.5 1.1 1.1 0.2 0.4 0.4 -1.0
Depression (Nagel 2018) 0.6 0.9 3.1 1.8 0.2 -0.3 -0.1 -1.0
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.0 0.9 -0.6 1.4 0.2 1.0
Neuroticism (Nagel 2018) 0.5 1.2 2.7 -0.2 1.0 0.7 -1.4 -1.6
Schizophrenia (2018) 1.5 3.2 8.3 -0.6 1.5 2.0 -2.9 -1.0
Schizophrenia vs Biploar Disorder 0.7 0.9 3.3 -0.5 0.0 -1.8 0.9 0.5
Worry (Nagel 2018) 0.9 1.9 3.8 -1.1 1.0 0.8 -1.8 -1.9
Alzheimer’s Disease (in mother) 2.7 3.2 12.2 -0.6 1.5 0.3 -3.5 -1.0
Alzheimer’s Disease (in father) 0.5 0.6 0.7 0.6 0.8 0.9 0.8 -0.7
Alzheimer’s Disease (including proxy) 2.2 3.3 6.2 -0.7 2.5 1.4 -2.0 -1.9
Crohns Disease (2017) 0.9 1.9 3.5 -0.6 1.9 -1.3 -1.4 -1.3
Irritable Bowel Disease (IBD) 1.3 3.0 4.8 -1.2 2.2 -1.8 -0.8 -2.2
Ulcerative Colitis (UC) 1.0 1.8 3.8 -0.9 1.6 -1.4 0.3 -1.9
Major Depression (MDD) 3.3 4.0 11.4 1.2 -1.4 -2.2 -3.4 0.7
Reaction Time 0.9 1.8 4.5 1.2 -1.1 1.3 -2.1 0.1
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.3 0.2 0.5 0.4 0.5 -0.1
Breast Cancer 0.6 1.3 2.9 1.6 -0.6 -0.5 1.7 0.9
Ovarian Cancer 1.6 2.1 5.3 2.0 0.5 2.3 0.9 0.5
Prostate Cancer 0.7 1.0 2.5 -1.6 0.1 0.9 1.1 -0.7
Age at First Birth 0.5 0.8 2.2 -1.1 -0.2 -1.5 0.1 -0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 1.5 0.6 -0.3 -1.2 -0.7 -0.4
Coronary Artery Disease (CAD) 0.1 0.1 0.4 -0.0 -0.2 -0.6 0.1 -0.2
Crohns Disease (2012) 1.6 2.5 11.0 -0.8 0.1 -0.7 -3.3 -0.7
Mean Putamen Volume 2.7 3.1 7.2 2.7 -2.3 0.5 -0.1 1.7
Fasting Glucose 0.4 0.5 1.1 1.0 0.1 1.0 0.6 0.2
HbA1C 0.4 0.5 1.3 0.1 0.2 1.1 0.9 0.5
HDL Cholesterol 0.3 0.5 0.9 -0.7 -0.9 -0.4 -0.9 0.2
LDL Cholesterol 0.3 0.4 1.0 0.5 0.6 -0.3 1.0 -0.8
Lupus 0.1 0.2 0.9 -0.2 -0.1 0.9 0.3 -0.3
Neuroticism (2016) 0.3 0.4 1.3 1.1 -0.6 -0.2 0.3 -0.2
Primary Biliary Cirrhosis 0.4 0.6 2.0 -0.7 0.2 0.7 -0.3 -1.4
Rheumatoid Arthritis 0.3 0.4 1.6 0.3 -0.5 0.2 1.2 -0.1
Schizophrenia (2014) 0.7 1.7 7.5 -0.7 0.2 0.3 -2.7 -0.4
Triglycerides 0.7 1.2 3.0 1.7 -0.9 -0.8 1.3 0.3
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.9 0.8 -1.6 -0.1 -1.7 0.9
Ulcerative Colitis 1.2 1.8 3.9 -1.6 1.6 -0.0 -0.1 -2.0
Blood Eosinophil Count 0.4 2.7 10.1 0.5 -1.0 1.5 -3.2 0.4
Blood Platelet Count 0.3 3.5 9.9 -0.2 -2.2 -1.2 -3.1 0.9
Blood Red Count 0.3 3.3 5.3 2.3 -1.0 -1.2 1.9 2.2
Blood White Count 0.1 0.4 1.0 -0.8 0.6 -0.2 0.0 -1.0
Heel T-Score 0.2 1.3 3.3 -0.3 -0.6 -1.6 -1.8 -0.1
BMI 1.0 5.9 12.9 3.6 -2.2 0.6 0.1 3.3
Height 0.6 11.3 23.1 -2.9 4.8 3.3 0.7 -3.7
Waist Hip Ratio (WHR) 0.3 1.4 2.0 0.7 0.9 1.3 1.4 -1.4
Systolic Blood Pressure 0.5 2.4 7.1 -1.3 1.1 0.8 -2.7 -1.2
Smoking Status 0.3 0.6 2.5 0.2 1.6 0.7 0.1 -0.1
Allergy or Eczema 0.2 0.6 2.7 -0.3 0.3 1.6 0.1 -0.5
Cardiovascular Disease 0.3 0.9 2.2 -0.7 0.0 -0.8 -1.5 -1.1
Hypothyroidism (self reported) 0.8 1.8 4.0 0.0 -1.4 -1.8 -2.0 -0.0
Respiratory disease 1.1 2.4 8.1 -1.4 0.5 0.4 -2.8 -1.2
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.0 1.0 0.3 0.8 -0.5 -0.4
Lung FEV1/FVC ratio 0.3 1.7 5.2 2.3 -0.0 -0.4 1.5 0.9
Lung FVC 1.1 5.4 10.4 -3.2 1.8 -3.0 1.8 -1.2
Neuroticism 0.2 0.6 1.4 -0.1 -0.2 -0.2 -1.1 -1.2
Chronotype (morning person) 0.2 0.4 1.5 -0.7 -0.1 0.2 0.2 1.2
Hair Pigment 0.0 0.5 1.7 0.3 -0.5 0.2 0.8 1.3
Tanning 0.4 4.3 9.9 0.0 -2.8 -3.1 -1.8 0.8
Hand grip strength (left) 0.5 1.4 3.5 -0.9 1.9 0.7 1.4 0.3
Number of treatments/medications taken 0.7 1.3 3.0 1.3 0.8 0.1 -1.7 -1.0
Average weekly spirits intake 1.7 2.1 6.5 -0.1 -1.8 0.0 -2.6 0.9
Sensitivity / hurt feelings 0.7 1.2 5.9 -0.1 0.4 2.4 -0.2 -0.3
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.0 1.4 0.1 -0.2 -0.7 -0.4
Hearing difficulty/problems: Yes 1.2 1.8 4.5 1.8 0.5 0.9 2.1 0.5
Relative age of first facial hair 0.5 1.0 2.9 -0.8 1.7 -0.3 1.2 -0.4
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.9 1.0 0.2 1.3 -1.4 -0.1
Ever used hormone-replacement therapy (HRT) 1.3 1.6 4.9 -0.6 -0.2 -0.8 -2.2 -1.5
Ever had hysterectomy (womb removed) 0.4 0.5 1.9 0.7 -0.1 1.4 -0.1 -0.1
Systolic blood pressure, automated reading 0.5 1.6 3.3 -0.6 1.5 1.3 -1.8 -0.6
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.9 0.2 0.7 1.4 -0.6 -1.7
Angina 0.9 1.2 2.4 -0.4 -1.5 -1.0 1.5 0.5
Medication for hormone replacement therapy 2.1 2.4 5.3 -0.6 1.7 0.1 -1.8 -2.3
Vitamin and mineral supplements 0.5 0.6 2.1 0.6 -0.5 0.5 1.5 -0.2
Supplements: Zinc 0.3 0.3 1.2 -0.3 0.4 0.0 -1.1 -0.3
Medication: Co-codamol 1.0 1.2 1.8 0.8 -1.3 -0.5 -1.3 1.2
Medication: Metformin 0.4 0.6 1.7 0.3 0.4 1.3 -0.9 -0.0
Diabetes (father) 0.4 0.5 1.4 0.8 -0.4 1.2 0.2 0.3
Diabetes (mother) 0.2 0.3 0.7 0.4 0.1 0.0 -0.8 0.6
Severe depression (siblings) 1.6 1.8 6.0 -0.0 1.2 0.1 -2.4 -1.2
Pack years adult smoking proportion 0.1 0.1 0.4 0.4 -0.4 -0.1 0.1 0.6
Impedance of leg (right) 0.4 1.9 6.4 -0.3 -0.7 -2.5 -1.0 -1.2
Leg fat-free mass (left) 0.4 2.1 6.8 1.4 0.3 2.6 0.4 1.3
Trunk fat percentage 1.3 5.1 12.2 3.5 -2.1 0.3 -0.9 2.8
Hand grip strength (right) 0.7 1.9 3.3 -1.6 1.6 1.1 1.8 0.0
Townsend deprivation index at recruitment 0.8 1.1 4.3 -0.3 -0.5 0.6 -2.1 0.5
Current tobacco smoking 0.2 0.3 0.5 0.7 0.4 0.6 -0.6 0.2
Average weekly fortified wine intake 0.8 0.9 3.0 -1.7 0.4 -0.4 -0.7 -0.9
Maternal smoking around birth 2.5 3.6 12.0 3.5 -0.6 1.1 -0.4 2.1
Fed-up feelings 0.3 0.6 2.8 0.4 -0.4 -1.7 -0.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.8 1.9 -0.5 -0.5 -0.5 -0.2
Relative age voice broke 1.5 2.2 5.8 -1.3 1.5 -2.4 0.9 -0.7
Taking other prescription medications 0.3 0.5 0.9 0.9 0.1 -0.4 -0.8 -1.0
Age when periods started (menarche) 0.9 2.2 8.8 0.5 3.0 -0.4 0.5 -1.1
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 11.7 0.0 -1.0 -0.9 -3.4 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.9 -0.8 -0.9 -0.5 -2.0 0.8
Tinnitus: Yes, but not now, but have in the past 1.3 1.3 4.5 2.1 -0.3 -1.2 0.5 0.6
Qualifications: CSEs or equivalent 0.6 0.8 1.8 1.3 0.2 1.4 0.1 0.8
Serious illness, injury or assault to yourself 0.9 1.1 3.3 1.8 0.0 1.2 -0.8 0.3
High blood pressure 0.3 0.8 3.3 -0.8 -0.0 -1.8 -0.2 -0.4
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.0 -1.0 -0.2 0.7 -0.3 -0.7
Multivitamins +/- minerals 0.5 0.6 2.3 0.2 -0.0 0.8 -1.5 0.4
Stomach or abdominal pain in last month 0.6 0.7 1.5 1.0 -0.8 -0.8 -1.2 0.2
Supplements: Glucosamine 0.4 0.5 0.9 -0.5 -0.7 0.2 -0.8 1.0
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 3.2 0.4 -0.1 -1.8 -0.8 0.2
Medication: Atenolol 0.5 0.6 2.5 0.1 -0.2 -0.6 1.6 0.0
Medication: Levothyroxine sodium 0.2 0.4 1.5 0.5 -1.2 -0.3 -0.4 0.0
Sitting height 0.1 0.9 1.3 -1.1 1.0 -1.1 0.5 -1.1
Chronic bronchitis/emphysema (father) 1.3 1.5 3.6 0.6 0.6 1.9 1.6 0.9
High blood pressure (mother) 1.5 2.0 6.8 1.7 0.2 -0.4 -2.6 0.5
Body mass index (BMI) 1.1 4.9 10.3 3.2 -1.5 1.7 -1.3 2.7
Impedance of leg (left) 0.6 2.7 9.5 -1.0 -0.3 -3.1 -1.1 -1.3
Leg predicted mass (left) 0.4 2.3 7.1 1.5 0.3 2.7 0.5 1.4
Trunk fat mass 1.0 4.3 10.9 3.3 -1.6 1.1 -0.7 2.6
Waist circumference 1.1 4.0 12.1 3.5 -0.4 2.2 -0.5 1.6
Number of incorrect matches in round 2.1 3.6 7.1 -2.7 0.5 0.4 -2.1 -2.5
Past tobacco smoking 0.6 1.1 2.0 -0.7 -1.3 -0.7 -0.9 -1.4
Alcohol usually taken with meals 0.6 0.9 2.8 0.3 0.2 1.7 1.1 0.7
Nervous feelings 0.6 1.0 3.7 -1.0 0.0 0.4 -1.9 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.9 1.7 0.1 0.5 1.1 0.1
Hearing difficulty/problems with background noise 1.4 2.2 7.3 -0.0 1.6 1.1 2.7 -0.4
Hair/balding pattern: Pattern 2 0.2 0.3 0.6 -0.5 -0.3 0.8 -0.5 -0.3
Had menopause 1.1 1.3 2.5 -1.1 0.8 0.0 -1.5 -1.6
Had other major operations 1.6 2.0 8.1 2.8 -0.3 1.1 -0.6 0.1
Forced vital capacity (FVC) 0.7 2.6 7.2 -2.7 1.1 -1.0 1.9 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 4.7 0.6 -1.3 0.1 -2.2 1.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.7 0.9 0.7 0.3 -0.5 -0.6
Qualifications: None of the above 0.2 0.4 1.7 -0.3 0.3 -1.3 -0.3 -0.5
Financial difficulties in last 2 years 2.3 3.0 8.5 2.9 -1.1 0.9 -1.0 1.9
Mouth/teeth dental problems 0.4 0.6 2.6 0.3 -1.6 0.5 -0.4 0.2
Heart attack 0.5 0.6 1.9 0.9 -0.4 -1.4 0.5 0.4
Allergy 0.6 1.3 2.4 1.4 -0.9 -0.9 0.8 1.6
Pain all over the body in last month 1.1 1.2 2.9 0.9 -1.4 -0.2 0.4 1.7
Diabetes (self-reported) 0.1 0.1 0.4 0.3 0.2 0.1 -0.6 -0.1
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.9 0.0 1.0 0.7 -1.7 -1.2
Medication: Ramipril 0.5 0.7 2.7 0.1 0.4 -1.6 0.1 -0.7
Medication: Simvastatin 0.1 0.2 0.5 0.7 -0.5 -0.1 0.4 0.2
Fluid intelligence score 0.2 0.5 1.1 0.3 0.9 1.0 0.4 0.4
Illnesses of siblings 1.5 2.1 5.3 -1.0 1.7 2.3 1.2 -0.3
Neuroticism score 0.2 0.4 0.9 -0.0 -0.5 0.1 -1.0 -0.9
Weight 0.7 3.4 7.2 2.7 -0.4 2.4 -0.6 1.9
Impedance of arm (right) 0.2 1.0 3.2 -0.1 -0.4 -1.8 0.7 -1.0
Arm fat percentage (right) 1.4 5.5 13.6 3.7 -1.9 1.3 -1.0 2.7
Trunk fat-free mass 0.4 2.0 7.6 0.1 1.6 2.8 -0.1 -0.2
Hip circumference 0.7 3.0 7.1 2.7 -0.3 1.8 -1.5 1.4
Time employed in main current job 0.9 1.0 3.3 -1.0 1.8 0.5 0.3 -0.6
Alcohol intake versus 10 years previously 0.8 1.1 3.6 0.5 -1.3 -0.3 -1.9 -0.2
Father’s age at death 0.7 0.9 2.5 -1.6 0.5 0.4 1.0 -0.7
Worrier / anxious feelings 2.5 4.6 9.6 -3.1 2.2 0.1 -0.7 -2.8
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 4.0 2.0 -1.6 -0.1 -0.7 0.7
Falls in the last year 1.2 1.6 3.2 1.8 -0.6 0.9 0.9 1.6
Hair/balding pattern: Pattern 3 0.7 1.1 4.4 0.6 0.8 0.4 2.1 0.0
Number of live births 2.3 3.2 9.9 3.1 -2.1 -0.2 -0.7 1.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.3 -1.2 0.8 -1.0 1.5 -0.1
Pulse rate 3.7 6.2 13.0 1.3 -3.6 -0.8 1.9 3.5
Happiness 0.6 0.8 2.6 0.3 0.2 1.1 -1.6 0.0
Noisy workplace 0.7 0.9 2.4 -0.2 1.2 -1.6 -0.2 0.7
Qualifications: A levels/AS levels or equivalent 0.4 0.8 3.5 0.6 0.4 -0.0 1.9 0.0
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.2 0.8 -0.8 -0.8 0.3 1.8
Mouth/teeth dental problems: Dentures 0.5 0.8 2.2 -0.4 1.5 0.1 -1.0 -0.9
Asthma 1.1 2.1 3.8 -1.9 0.6 1.1 -1.8 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.3 1.1 -0.3 0.8 0.4 0.4
Medication: Cholesterol lowering 0.1 0.1 0.3 -0.1 -0.4 -0.5 0.6 0.1
Depression (self-reported) 1.2 1.4 5.5 0.9 -0.8 0.0 -2.3 0.4
Medication: Lansoprazole 1.0 1.1 1.8 1.3 -1.0 -1.1 -1.2 0.4
Prospective memory result 4.7 5.8 13.5 -3.7 1.1 -0.8 -2.7 -2.5
Lung cancer (father) 0.4 0.4 1.3 0.3 -0.6 -0.4 -1.1 0.5
Illnesses of mother 0.8 1.0 1.8 -0.4 -1.4 1.0 1.3 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 2.7 -1.2 1.2 -1.4 1.6 -0.3
Pulse wave Arterial Stiffness index 1.2 1.4 2.6 1.0 -0.2 1.6 1.6 0.8
Impedance of arm (left) 0.4 1.8 6.9 -0.4 -0.7 -2.6 0.8 -1.0
Arm fat mass (right) 1.1 4.5 10.6 3.3 -1.5 1.4 -1.1 2.5
Trunk predicted mass 0.3 2.0 7.5 0.2 1.5 2.7 -0.2 -0.1
Standing height 0.2 2.3 4.5 -1.0 2.1 1.5 1.2 -1.4
Length of working week for main job 4.0 4.4 10.7 3.3 -2.4 -0.6 0.5 2.2
Exposure to tobacco smoke at home 1.3 1.5 2.7 0.3 -1.6 -1.6 0.3 1.4
Breastfed as a baby 1.4 1.8 2.7 -1.6 1.5 0.8 -1.5 -1.1
Tense / ‘highly strung’ 0.8 1.3 5.0 -1.0 -0.2 0.2 -2.2 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.4 1.2 0.8 0.5 -0.3 -0.0
Hair/balding pattern: Pattern 4 0.2 0.4 1.1 -1.1 0.2 -0.5 -0.3 -0.6
Birth weight of first child 0.9 1.6 2.7 -0.6 1.6 1.5 -1.6 -0.2
Peak expiratory flow (PEF) 0.2 0.4 1.3 -0.2 0.5 -0.0 1.1 0.7
Pulse wave reflection index 1.3 1.7 3.9 0.3 1.6 2.0 0.5 -1.2
Ever highly irritable/argumentative for 2 days 2.1 2.5 9.5 3.1 -0.4 1.1 -0.4 1.2
Loud music exposure frequency 0.8 0.8 2.7 0.4 0.7 1.6 0.9 0.1
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.8 0.4 0.0 1.4 1.3 0.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.2 -0.6 -0.1 0.0 1.1 0.8
Blood clot in the leg (DVT) 0.4 0.5 1.0 0.3 0.7 0.7 -0.7 -1.0
Medication: Paracetamol 1.1 1.8 3.0 1.7 1.6 1.0 1.4 0.5
Headache pain in last month 0.3 0.6 1.3 0.7 1.1 0.0 -0.3 -1.0
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.8 -0.2 -0.6 -0.3 -0.9 -0.0
Glaucoma (self-reported) 1.6 1.9 3.1 1.8 -1.3 0.1 1.7 1.2
Gout (self-reported) 0.7 1.0 2.1 -1.4 -0.6 -0.6 -1.4 0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 0.9 0.8 -1.0 -0.6 -0.6 0.0
Medication: Amlodipine 0.5 0.7 2.5 -0.4 0.9 -0.2 0.4 -1.6
Medication: Ventolin 100micrograms inhaler 1.2 1.5 2.4 -1.1 1.0 1.6 -0.9 -1.5
Birth weight 0.2 0.4 1.3 -0.3 1.1 0.3 0.5 -0.7
Chronic bronchitis/emphysema (mother) 1.3 1.5 5.2 2.3 -0.3 1.1 -0.9 0.5
High blood pressure (siblings) 1.3 1.8 3.4 1.3 -1.1 -1.6 -1.8 0.7
Forced vital capacity (FVC), Best measure 0.8 2.9 4.9 -2.2 1.6 -1.5 2.0 -0.7
Body fat percentage 1.4 5.4 12.5 3.5 -2.2 0.6 -1.3 2.8
Leg fat percentage (right) 1.5 5.5 14.0 3.7 -2.1 0.8 -1.0 2.7
Arm fat-free mass (right) 0.2 1.1 3.2 0.8 0.5 1.8 -0.8 1.0
Exposure to tobacco smoke outside home 0.7 0.9 2.0 0.7 1.4 1.1 0.5 0.7
Comparative body size at age 10 0.4 1.0 4.2 0.4 -0.4 -2.0 -0.4 -0.7
Number of full brothers 0.8 1.0 3.0 0.4 0.2 -1.2 -1.7 -0.3
Worry too long after embarrassment 0.8 1.3 3.2 -0.3 -1.7 -0.3 -1.8 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.0 -0.3 0.3 1.4 -0.6 -1.1
Wheeze or whistling in the chest in last year 0.7 1.2 3.0 1.2 1.0 0.7 -1.7 0.3
Number of children fathered 3.0 3.4 6.8 2.6 -2.1 -0.1 -0.5 2.3
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.5 -1.2 -1.2 -0.4 -1.2 -0.2
Age at first live birth 0.9 1.6 3.9 -1.0 2.0 -0.2 1.3 -1.2
Pulse wave peak to peak time 1.3 1.5 2.8 -1.1 0.2 -1.6 -1.7 -0.9
Health satisfaction 0.5 0.7 1.7 0.8 1.3 1.0 -0.3 -0.2
Shortness of breath walking on level ground 0.5 0.6 2.4 0.3 1.6 0.3 -0.5 -0.1
Qualifications: College or University degree 0.5 1.4 2.4 -1.4 1.6 1.0 1.2 -0.7
Eye problems/disorders: None of the above 0.6 0.6 1.6 0.2 -1.3 -0.5 0.7 0.9
Mouth/teeth dental problems: Loose teeth 1.1 1.3 1.9 1.4 -1.4 -0.5 -0.9 1.3
Emphysema/chronic bronchitis 0.9 1.0 2.0 1.3 1.4 1.0 0.1 0.7
Medication for pain relief, constipation, heartburn 0.5 0.8 3.2 -1.8 -0.1 0.5 -0.6 0.0
Neck or shoulder pain in last month 0.1 0.2 0.3 0.4 -0.2 -0.5 0.3 0.6
Medication: Blood pressure 0.3 0.6 1.1 -0.1 0.9 0.8 1.1 -0.5
Angina (self-reported) 1.0 1.4 2.7 -0.2 -1.6 -1.0 1.6 0.8
Migraine (self-reported) 0.9 1.1 3.8 -0.4 -1.0 -0.4 -1.9 -0.4
Medication: Ibuprofen 0.4 0.5 1.6 0.7 -0.3 1.3 -0.2 0.4
Medication: Allopurinol 0.8 1.0 2.0 -1.2 -0.8 -1.4 -1.0 0.2
Medication: Omeprazole 0.6 0.7 1.2 0.8 -1.1 -1.0 -0.7 0.5
Medication: Seretide 50 evohaler 2.5 2.9 5.5 -2.4 2.0 1.6 0.0 -1.4
Mean time to correctly identify matches 0.9 1.7 5.7 1.1 -1.2 0.6 -2.4 -0.3
Heart disease (mother) 0.8 1.0 3.1 -0.1 0.9 -1.8 0.9 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.8 -0.9 0.3 0.2 -0.5 -0.5
Whole body fat mass 1.0 4.2 9.6 3.1 -1.8 0.9 -0.9 2.6
Leg fat mass (right) 1.4 5.4 12.7 3.6 -1.8 1.4 -0.7 2.9
Arm predicted mass (right) 0.2 0.9 3.0 0.8 0.5 1.7 -0.5 0.8
Pulse rate, automated reading 6.2 20.0 38.5 4.8 -5.1 -1.4 3.4 6.2
Alcohol intake frequency. 1.0 2.4 5.7 1.1 -1.9 -0.6 -2.4 1.0
Comparative height size at age 10 0.3 1.8 7.2 0.4 0.6 2.7 -0.1 -1.1
Number of full sisters 0.7 0.9 3.6 1.9 -0.2 0.7 -0.4 -0.4
Suffer from ‘nerves’ 0.6 1.0 3.1 1.1 -0.7 -0.1 -1.8 -0.3
Overall health rating 0.9 1.9 5.7 2.4 -1.1 -1.1 -0.2 1.2
Chest pain or discomfort 0.5 0.7 1.9 1.0 0.3 0.2 1.4 0.6
Had major operations 0.2 0.3 0.5 0.4 0.4 -0.5 -0.7 0.6
Age at last live birth 0.7 1.1 2.3 -0.5 1.5 0.3 1.2 -1.2
Family relationship satisfaction 0.9 1.2 3.8 -0.1 1.1 0.5 -1.9 -0.7
Leg pain on walking 1.3 1.6 4.5 -0.8 0.6 0.4 -2.1 -1.5
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.0 2.7 1.2 -0.5 -0.7 -0.7 1.7
Commuting to job workplace: Car/motor vehicle 1.4 1.6 4.0 2.0 -0.2 1.6 0.6 1.1
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 4.8 -2.2 0.9 -1.0 0.8 -1.8
Medication: Aspirin 0.2 0.3 1.2 0.1 -0.6 -1.1 0.3 -0.1
Supplements: Vitamin C 1.2 1.4 5.2 -0.7 0.9 -2.3 0.3 -0.7
Knee pain experienced in last month 1.7 2.7 6.2 2.5 -1.3 1.1 1.1 1.8
Hypertension (Self-reported) 0.2 0.5 1.5 -0.7 -0.1 -1.2 -0.5 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 2.1 0.6 0.4 -1.4 0.5 -1.2
Illnesses of father: Heart disease 1.2 1.6 3.8 -0.3 -2.0 -0.6 -1.8 0.8
Illnesses of siblings: Diabetes 0.5 0.6 1.9 1.4 0.7 0.4 -0.5 0.3
Smoking status: Previous 0.5 0.7 2.0 -0.0 1.4 0.7 0.2 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 1.2 -0.8 1.1 0.7 -0.3 -0.5
Whole body fat-free mass 0.3 1.9 7.3 0.7 1.1 2.7 0.1 0.6
Leg fat-free mass (right) 0.4 1.9 6.3 1.0 0.8 2.5 0.6 1.2
Arm fat percentage (left) 1.4 5.6 13.8 3.7 -2.2 0.8 -1.0 2.8
Average weekly red wine intake 1.8 2.6 8.1 0.6 -1.5 -1.2 -1.1 2.8
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.6 0.7 0.4 1.3 -0.4 -0.7
Mood swings 0.5 1.0 3.0 1.7 -0.2 1.2 0.3 -0.4
Loneliness, isolation 1.2 1.7 6.4 -0.0 -1.0 -2.5 -0.9 -0.6
Long-standing illness, disability or infirmity 0.2 0.2 0.9 1.0 0.1 -0.0 -0.5 0.2
Ever had bowel cancer screening 0.3 0.4 0.8 0.2 -0.9 -0.7 -0.2 0.7
Diabetes diagnosed by doctor 0.3 0.5 1.0 0.7 0.6 0.9 -1.0 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.5 1.2 -0.0 0.7 -1.0 0.3
Friendships satisfaction 1.2 1.5 5.3 1.2 -0.6 0.1 -2.3 -0.5
Qualifications: nursing, teaching 0.8 1.3 4.1 1.2 -0.4 2.0 0.9 0.1
Commuting to job workplace: Walk 1.6 1.7 3.6 -1.9 -0.7 -1.3 -1.3 -1.1
Eye problems/disorders: Cataract 0.8 0.9 1.9 0.2 1.0 0.7 -1.4 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.8 0.7 1.1 -0.7 1.4 -0.4
Medication for cholesterol 1.1 1.6 5.4 -0.1 0.7 2.3 1.4 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.8 1.4 0.0 -1.0 0.0 0.1
Back pain experienced in last month 0.9 1.2 4.9 1.0 -0.1 0.3 -2.2 -0.5
Mineral and other dietary supplements 0.8 1.1 2.8 1.0 1.3 0.2 1.7 -0.4
Breast cancer (self-reported) 0.6 0.7 2.2 0.5 -0.1 -0.6 1.5 0.9
Asthma (self-reported) 0.9 1.8 3.5 -1.5 0.5 1.2 -1.9 -1.2
Osteoporosis (self-reported) 0.5 0.6 1.4 1.2 0.3 0.9 0.6 -0.3
Osteoarthritis (self-reported) 0.3 0.3 1.5 1.2 -0.4 0.1 0.1 0.2
Medication: Aspirin 0.2 0.3 1.1 0.2 -0.6 -1.0 0.2 0.0
Medication: Gliclazide 1.2 1.4 3.1 1.7 0.5 1.8 0.0 0.8
Illnesses of father: None of the above (group 1) 0.5 0.7 1.4 0.7 1.2 0.3 1.1 -0.1
Smoking status: Current 0.2 0.3 0.8 0.9 0.2 0.5 -0.2 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 3.0 -1.1 0.3 -1.7 1.6 0.3
Whole body water mass 0.3 1.6 6.5 0.7 0.9 2.5 -0.0 0.6
Leg predicted mass (right) 0.3 1.8 5.5 1.0 0.7 2.3 0.7 1.2
Arm fat mass (left) 1.1 4.5 10.3 3.2 -1.6 1.2 -1.0 2.7
Number of self-reported non-cancer illnesses 1.2 2.0 3.8 -0.3 0.4 -1.8 -1.9 -1.7
Average weekly champagne plus white wine intake 0.5 0.6 2.2 -0.5 0.6 -0.5 1.5 0.3
Miserableness 0.3 0.5 1.4 0.2 0.4 0.7 0.3 -1.2
Guilty feelings 0.3 0.4 1.6 0.2 -0.6 0.1 -1.3 0.4
Wears glasses or contact lenses 0.5 0.6 1.4 -0.2 1.2 -0.2 -0.3 -1.1
Ever taken oral contraceptive pill 0.2 0.2 0.5 -0.2 0.0 0.6 -0.4 0.7
Hearing aid user 0.2 0.2 0.4 -0.2 0.5 -0.6 -0.4 0.6
Mother’s age at death 1.5 1.9 5.2 -2.3 0.3 -0.9 1.3 -1.3
Financial situation satisfaction 0.9 1.2 2.3 1.4 -0.5 1.5 1.1 0.3
Tinnitus: Yes, now most or all of the time 2.0 2.3 7.3 -0.7 1.9 0.3 2.7 -0.5
Commuting to job workplace: Public transport 1.2 1.4 2.7 -0.7 1.4 0.5 1.6 -1.2
Eye problems/disorders: Glaucoma 1.4 1.7 2.3 1.2 -1.5 -0.8 1.5 1.2
Medication: Blood pressure 0.4 0.8 3.5 -0.3 -0.4 -1.9 -0.3 -0.3
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.2 1.1 -0.7 0.6 -0.5 0.9
Supplements: Fish oil (including cod liver oil) 1.2 1.6 3.9 -1.4 -1.1 -0.9 -2.0 -0.2
High cholesterol (Self-reported) 0.7 1.2 2.1 -1.2 -1.4 -1.2 -0.9 -0.2
Medication: Bendroflumethiazide 0.6 0.9 2.6 -1.6 0.6 -0.8 0.3 -0.9
Medication: Paracetamol 0.7 1.1 3.0 1.7 1.2 0.7 0.4 0.2
Medication: Lisinopril 0.5 0.7 2.2 0.8 -1.5 -0.5 -0.5 0.4
Medication: Atorvastatin 1.5 1.9 5.2 -1.1 -1.4 -0.6 -2.3 0.8
Illnesses of father: High blood pressure 1.7 2.1 3.1 -1.8 0.7 -1.6 -1.7 -1.3
Alcohol drinker status: Never 1.4 1.7 7.8 0.1 -0.2 0.7 -2.8 -0.0
Ever smoked 0.4 0.7 1.7 0.5 0.9 0.8 0.5 1.3
Basal metabolic rate 0.3 1.9 6.6 1.2 0.7 2.6 -0.2 0.9
Leg fat percentage (left) 1.2 4.2 10.3 3.2 -1.7 0.7 -1.2 2.5
Arm fat-free mass (left) 0.3 1.6 5.3 1.1 0.8 2.3 -0.6 0.6
Number of operations (self-reported) 1.0 1.5 4.4 1.4 -0.7 -0.2 -2.1 0.8
Average weekly beer plus cider intake 1.1 1.7 4.3 -2.1 1.1 -0.6 -0.3 -1.5
Irritability 0.6 1.0 2.9 -0.9 0.9 0.1 -0.7 -1.7
Risk taking 0.5 0.7 1.8 0.7 -0.4 -0.9 -1.4 0.4
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.5 1.2 -0.9 0.1 0.7 0.8
Fractured/broken bones in last 5 years 1.7 2.2 5.2 0.8 -2.3 -1.7 0.7 1.2
Age started oral contraceptive pill 0.3 0.3 0.7 -0.8 0.1 -0.7 0.1 -0.6
Diastolic blood pressure, automated reading 1.6 5.1 12.6 3.0 -1.7 0.9 -0.5 3.6
Ever depressed for a whole week 0.5 0.7 1.3 1.1 0.4 0.3 -1.1 -0.8
Unable to work because of sickness or disability 0.7 0.9 2.3 0.3 0.8 1.5 -0.9 0.7
Commuting to job workplace: Cycle 0.5 0.6 1.6 -0.5 0.4 1.3 0.0 -1.0
Myopia 0.2 0.4 0.9 0.3 -0.1 1.0 -0.7 0.5
Vascular/heart problems diagnosed by doctor 0.3 0.7 3.1 0.5 0.2 1.8 -0.6 0.2
Cholesterol lowering medication 1.0 1.5 4.2 -0.8 -1.3 -1.0 -2.1 0.3
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 2.5 0.7 -1.5 -1.6 -1.2 0.3
Pain experienced in last month 0.2 0.4 0.8 -0.9 -0.1 -0.0 -0.6 -0.8
Supplements: Calcium 0.3 0.4 1.1 0.3 -0.6 0.6 -1.0 0.1
Basal cell carcinoma (self-reported) 0.5 0.7 1.3 0.8 -1.1 -0.3 -0.2 1.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.7 0.6 -0.4 -1.3 0.3 0.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.0 0.2 0.9 0.5 -0.7 -1.4
Heart disease (siblings) 1.2 1.5 4.0 -0.0 -1.8 -2.0 -0.2 0.2
Alcohol drinker status: Previous 1.0 1.1 4.0 2.0 -1.1 -0.0 -0.2 0.7
Pack years of smoking 0.2 0.4 0.6 0.8 -0.7 -0.3 0.1 0.7
Impedance of whole body 0.3 1.8 7.0 -0.5 -0.3 -2.6 0.0 -1.2
Leg fat mass (left) 1.2 4.6 10.7 3.3 -1.6 1.3 -0.8 2.7
Arm predicted mass (left) 0.3 1.4 4.3 1.0 0.7 2.1 -0.8 0.7