Hub : Genes

WIZ

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.1180	0.0490	0.0054	0.020	NA	0.063	NA	0.064	0.03100	NA	0.00038	NA	0.00032
2	GTEx	Breast Mammary Tissue (Female)	0.0864	0.0660	0.1200	-0.005	NA	-0.009	NA	-0.005	0.49000	NA	0.77000	NA	0.50000
3	GTEx	Nerve Tibial	0.1144	0.0405	0.0010	-0.002	NA	0.007	NA	-0.004	0.49000	NA	0.10000	NA	0.78000
4	TCGA	Bladder Urothelial Carcinoma	0.0240	0.0140	0.0019	0.035	0.029	0.031	NA	0.027	0.00061	0.0016	0.00110	NA	0.00210

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.0	3.2	4.9	0.3	-2.0	1.9	2.2
Bipolar Disorder or Schizophrenia	1.3	3.2	9.0	1.3	-0.7	3.0	1.4
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	-0.2	-0.6	1.2	-0.1
Depression (Nagel 2018)	0.3	0.4	0.6	-0.8	-0.5	0.6	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.7	0.7	0.2	-1.3	-0.1
Neuroticism (Nagel 2018)	0.3	0.6	2.1	-0.3	0.0	0.4	-1.4
Schizophrenia (2018)	0.9	1.9	5.3	1.4	0.8	2.3	-0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.6	0.0	-0.6	-0.9
Worry (Nagel 2018)	0.3	0.6	1.1	-0.8	-0.7	0.6	-1.0
Alzheimer’s Disease (in mother)	1.8	2.1	3.7	-1.3	-0.1	1.9	1.8
Alzheimer’s Disease (in father)	1.0	1.0	2.2	-0.6	-1.5	1.2	-0.5
Alzheimer’s Disease (including proxy)	0.9	1.3	3.0	-1.2	-0.6	1.7	0.6
Crohns Disease (2017)	3.3	7.2	21.9	-1.2	-2.2	0.8	-4.7
Irritable Bowel Disease (IBD)	1.8	4.3	14.1	0.2	-1.5	0.9	-3.8
Ulcerative Colitis (UC)	0.6	1.1	2.4	1.0	-0.9	-0.2	-1.5
Major Depression (MDD)	0.7	0.8	2.6	-0.6	-0.2	-0.7	-1.6
Reaction Time	1.8	3.4	9.7	0.6	3.1	0.7	-1.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.7	1.1	0.4	-0.7	1.3
Breast Cancer	0.2	0.6	1.3	-1.2	-0.4	0.9	-0.1
Ovarian Cancer	0.6	0.8	2.0	-1.4	-1.0	0.5	-0.2
Prostate Cancer	1.0	1.4	2.7	1.6	-1.1	-1.2	0.6
Age at First Birth	0.3	0.4	0.7	0.6	0.7	-0.1	0.8
Bipolar Disorder (2011)	0.5	0.5	1.6	-0.7	0.0	1.3	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.0	1.4	0.2	0.6	1.0
Coronary Artery Disease (CAD)	1.0	1.1	3.1	-1.8	0.0	0.9	0.8
Crohns Disease (2012)	3.1	5.0	13.6	-1.3	-2.1	0.5	-3.7
Mean Putamen Volume	0.3	0.4	1.1	0.6	1.1	-0.1	-0.3
Fasting Glucose	2.0	2.4	9.2	-0.3	-0.2	-0.4	3.0
HbA1C	0.6	0.6	1.6	-0.3	1.3	-0.9	0.2
HDL Cholesterol	0.7	1.2	2.8	0.1	1.7	1.3	-0.5
LDL Cholesterol	0.7	1.1	2.1	-0.2	-0.5	-1.4	-1.4
Lupus	1.0	1.4	5.3	0.4	-0.5	2.3	0.1
Neuroticism (2016)	0.2	0.3	1.2	-1.1	0.3	0.1	0.3
Primary Biliary Cirrhosis	1.0	1.4	4.3	-0.8	-2.1	0.4	0.7
Rheumatoid Arthritis	0.2	0.2	0.6	0.8	0.1	-0.5	0.0
Schizophrenia (2014)	1.1	2.5	6.1	1.8	0.8	2.5	-0.5
Triglycerides	0.1	0.2	0.5	-0.2	-0.7	-0.3	-0.0
Type 2 Diabetes (T2D) (2012)	4.3	4.9	9.2	1.2	2.3	-1.9	3.0
Ulcerative Colitis	0.6	0.9	2.8	0.9	-0.4	0.1	-1.7
Blood Eosinophil Count	0.1	1.1	1.5	1.2	1.1	0.7	1.0
Blood Platelet Count	0.7	8.4	31.2	-1.1	-0.7	-0.7	-5.6
Blood Red Count	0.6	6.2	10.4	1.9	2.8	1.7	-3.2
Blood White Count	0.1	0.4	1.5	0.0	-0.2	-0.1	-1.2
Heel T-Score	0.2	1.5	2.3	-0.1	1.5	1.2	1.4
BMI	0.4	2.1	5.2	1.1	2.3	1.2	0.8
Height	0.1	2.2	7.4	0.5	-1.1	-0.0	-2.7
Waist Hip Ratio (WHR)	0.7	3.1	10.8	0.1	0.2	1.3	3.3
Systolic Blood Pressure	0.1	0.4	1.6	-0.2	-0.1	-1.3	0.3
Smoking Status	0.4	0.8	1.2	-0.5	-1.1	-1.1	0.9
Allergy or Eczema	0.5	1.3	3.2	1.8	-0.8	0.6	-1.0
Cardiovascular Disease	0.5	1.6	1.7	1.3	1.1	1.3	1.2
Hypothyroidism (self reported)	0.2	0.4	1.4	-1.2	-0.2	0.3	0.4
Respiratory disease	0.5	1.1	2.4	-1.1	-1.6	-0.8	0.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.3	-1.8	-1.0	-0.5	0.7
Lung FEV1/FVC ratio	0.1	0.3	0.5	0.4	-0.6	-0.5	-0.7
Lung FVC	0.3	1.7	5.0	-0.8	-2.2	0.4	1.1
Neuroticism	0.2	0.5	1.7	0.1	-0.2	0.3	-1.3
Chronotype (morning person)	0.5	1.3	3.1	-0.7	-0.9	0.9	-1.8
Hair Pigment	0.1	2.0	5.8	-0.4	-0.9	-1.1	2.4
Tanning	0.2	1.9	3.1	-1.6	-1.2	-1.8	0.7
Hand grip strength (left)	0.2	0.5	1.0	-0.3	-1.0	-0.2	0.9
Number of treatments/medications taken	0.0	0.1	0.2	-0.3	0.4	0.2	-0.2
Average weekly spirits intake	0.6	0.8	2.3	-0.7	0.5	-1.5	0.0
Sensitivity / hurt feelings	0.4	0.7	1.3	1.1	-0.4	-0.8	-0.7
Frequency of depressed mood in last 2 weeks	1.2	1.7	2.4	-1.2	-1.5	0.8	-1.5
Hearing difficulty/problems: Yes	0.7	1.0	2.5	-0.7	0.8	1.6	-0.6
Relative age of first facial hair	0.3	0.7	2.3	0.3	-0.5	-0.2	1.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.7	-1.2	-1.0	-0.9	-1.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	-0.5	0.2	-0.2	-1.1
Ever had hysterectomy (womb removed)	1.4	1.5	5.3	-0.1	0.6	2.3	-0.7
Systolic blood pressure, automated reading	0.1	0.3	0.7	-0.5	0.5	-0.8	-0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	-0.3	1.3	0.6	0.7
Angina	0.4	0.6	2.2	-1.5	0.2	0.2	-0.1
Medication for hormone replacement therapy	1.5	1.6	5.7	-0.4	-0.4	-0.7	-2.4
Vitamin and mineral supplements	0.9	1.2	2.9	0.9	1.1	0.2	1.7
Supplements: Zinc	0.4	0.4	1.4	-0.3	-0.5	-0.2	-1.2
Medication: Co-codamol	0.4	0.4	1.3	-0.3	0.6	-1.2	-0.0
Medication: Metformin	0.3	0.5	1.3	-1.1	-0.1	-0.2	0.7
Diabetes (father)	0.9	1.1	2.0	1.1	1.4	-0.6	-0.9
Diabetes (mother)	1.6	2.0	4.8	2.2	1.5	-0.4	1.0
Severe depression (siblings)	0.6	0.6	1.0	-1.0	0.5	-0.6	-0.9
Pack years adult smoking proportion	0.5	0.8	2.6	-0.1	1.6	-0.3	0.6
Impedance of leg (right)	0.2	0.9	2.0	-0.9	-0.7	0.6	1.4
Leg fat-free mass (left)	0.1	0.4	1.3	-0.1	0.1	-0.4	-1.1
Trunk fat percentage	0.4	1.4	2.3	-0.3	1.0	1.5	1.5
Hand grip strength (right)	0.2	0.6	2.2	-0.1	-1.5	0.2	0.3
Townsend deprivation index at recruitment	0.7	1.0	3.3	-0.2	-0.2	0.7	-1.8
Current tobacco smoking	1.1	1.8	3.0	-1.4	-1.7	-1.3	-0.8
Average weekly fortified wine intake	0.6	0.7	2.2	1.5	-0.2	0.0	-0.8
Maternal smoking around birth	0.6	0.8	2.1	-0.0	1.4	1.0	0.6
Fed-up feelings	0.1	0.2	0.4	0.3	-0.4	0.6	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	0.3	0.2	1.0	-0.6
Relative age voice broke	1.3	2.0	4.0	-2.0	-1.0	0.4	1.7
Taking other prescription medications	1.1	1.6	3.4	-1.8	-1.5	-0.9	-0.1
Age when periods started (menarche)	3.4	8.1	25.5	0.1	-2.3	1.3	5.0
Bilateral oophorectomy (both ovaries removed)	1.8	2.0	2.9	1.6	1.4	1.7	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.0	0.5	1.4	0.3	0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.6	0.1	-1.2	-0.4	-0.6
Qualifications: CSEs or equivalent	4.9	6.5	16.4	2.8	1.3	4.0	0.2
Serious illness, injury or assault to yourself	1.1	1.3	4.6	-0.7	0.4	-2.1	-0.1
High blood pressure	0.3	0.8	2.0	0.7	1.4	0.3	0.8
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.7	1.5	-1.1	0.1	-2.2
Multivitamins +/- minerals	0.9	1.1	1.8	-1.3	-1.0	0.1	-1.3
Stomach or abdominal pain in last month	1.1	1.3	2.3	-0.4	0.8	1.5	-1.5
Supplements: Glucosamine	0.6	0.8	2.9	-0.0	-1.7	0.0	-0.4
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.3	-0.2	-0.8	-1.8	-0.0
Medication: Atenolol	0.3	0.3	0.7	-0.5	-0.3	-0.5	0.8
Medication: Levothyroxine sodium	0.2	0.4	1.4	-1.2	0.1	0.0	-0.3
Sitting height	0.3	2.0	5.8	-0.6	-1.3	-0.3	-2.4
Chronic bronchitis/emphysema (father)	1.0	1.2	3.2	1.2	0.1	0.4	1.8
High blood pressure (mother)	0.6	0.8	2.9	1.7	0.4	-0.3	-0.3
Body mass index (BMI)	0.2	1.0	2.3	-0.0	1.5	1.1	0.5
Impedance of leg (left)	0.4	1.9	3.1	-1.6	-1.4	0.1	1.8
Leg predicted mass (left)	0.1	0.4	1.3	-0.1	0.1	-0.4	-1.1
Trunk fat mass	0.2	1.0	1.8	-0.3	1.0	1.3	1.1
Waist circumference	0.4	1.6	2.5	-0.2	1.4	1.6	1.4
Number of incorrect matches in round	0.4	0.6	1.2	0.6	0.5	1.1	0.8
Past tobacco smoking	0.0	0.0	0.1	0.1	0.0	0.1	-0.2
Alcohol usually taken with meals	1.5	2.5	6.6	1.2	1.3	0.0	-2.6
Nervous feelings	0.6	1.2	3.2	-1.1	-1.8	-0.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	0.2	-0.7	0.6	-0.9
Hearing difficulty/problems with background noise	0.4	0.6	1.4	-0.6	0.4	0.7	-1.2
Hair/balding pattern: Pattern 2	0.5	0.6	2.0	0.3	1.4	0.5	-0.4
Had menopause	1.0	1.3	2.1	-1.4	-1.4	-0.4	-1.0
Had other major operations	1.5	1.8	5.9	1.1	0.5	0.2	-2.4
Forced vital capacity (FVC)	0.6	2.2	6.8	-0.7	-2.6	0.3	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.4	1.1	1.6	0.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	0.7	1.0	0.3	-0.5
Qualifications: None of the above	0.3	0.6	1.9	-1.4	0.5	-0.2	0.5
Financial difficulties in last 2 years	0.4	0.6	1.2	-0.6	0.5	1.1	-0.8
Mouth/teeth dental problems	1.2	1.8	4.3	0.5	2.1	-1.6	-0.3
Heart attack	0.9	1.1	2.1	-0.6	0.4	-1.4	1.3
Allergy	0.6	1.4	4.4	-0.8	0.3	-0.6	2.1
Pain all over the body in last month	2.4	2.6	5.7	-2.4	-1.3	-1.7	-0.3
Diabetes (self-reported)	0.5	0.8	2.8	-1.7	-0.4	-0.2	0.4
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.0	-0.0	-1.6	0.7	-2.2
Medication: Ramipril	0.3	0.4	0.7	0.6	0.0	0.6	0.8
Medication: Simvastatin	1.1	1.6	3.2	-1.6	-0.7	0.4	1.8
Fluid intelligence score	1.0	2.0	4.4	1.7	0.2	-2.1	0.9
Illnesses of siblings	2.9	4.0	6.5	-0.2	-2.5	-2.6	1.8
Neuroticism score	0.3	0.6	2.1	-0.2	-0.6	0.1	-1.4
Weight	0.1	0.3	0.6	-0.2	0.8	0.7	0.0
Impedance of arm (right)	0.2	0.8	2.0	1.4	-0.2	0.4	0.9
Arm fat percentage (right)	0.5	1.9	3.8	0.6	1.9	1.4	1.2
Trunk fat-free mass	0.1	0.7	2.3	-0.2	-0.1	-0.6	-1.5
Hip circumference	0.1	0.6	1.2	-0.1	1.1	1.1	-0.4
Time employed in main current job	0.1	0.2	0.3	-0.4	-0.6	-0.3	-0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.7	-0.9	0.3	-0.4	-0.4
Father’s age at death	0.7	0.9	2.1	1.1	-0.6	0.0	1.5
Worrier / anxious feelings	0.8	1.5	4.9	-0.3	-0.6	0.9	-2.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.6	0.1	0.2	-0.9	-1.3
Falls in the last year	0.3	0.4	1.6	-0.3	-0.3	-1.3	0.0
Hair/balding pattern: Pattern 3	1.1	1.6	6.2	0.0	-0.2	2.5	-0.5
Number of live births	2.1	3.0	6.2	1.4	-0.2	2.5	1.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	7.5	-0.6	-2.7	0.3	0.7
Pulse rate	0.7	1.1	2.5	-1.0	-0.6	-1.6	-0.9
Happiness	0.8	1.0	2.5	-0.2	-1.6	-0.6	-1.0
Noisy workplace	0.1	0.2	0.3	-0.2	-0.6	0.0	-0.6
Qualifications: A levels/AS levels or equivalent	1.8	3.9	6.3	2.3	-0.5	-2.5	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	-0.1	1.1	-1.1	0.7
Mouth/teeth dental problems: Dentures	1.6	2.7	5.6	-1.3	-0.3	1.9	2.4
Asthma	0.1	0.2	0.7	-0.4	-0.0	-0.9	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	-1.1	0.0	1.1	0.6
Medication: Cholesterol lowering	0.5	0.7	1.7	-1.0	-0.4	-0.0	1.3
Depression (self-reported)	0.6	0.7	2.3	1.5	0.1	0.5	-0.2
Medication: Lansoprazole	1.6	1.8	6.0	-2.4	-0.4	0.8	0.5
Prospective memory result	0.2	0.3	0.4	-0.6	0.2	0.6	0.6
Lung cancer (father)	0.3	0.4	0.7	0.1	0.4	0.8	-0.8
Illnesses of mother	0.8	0.9	2.4	-0.5	0.1	-1.5	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	6.9	-0.6	-2.6	-0.8	0.8
Pulse wave Arterial Stiffness index	0.9	1.1	1.8	-1.2	-0.2	1.0	1.4
Impedance of arm (left)	0.1	0.4	0.5	0.7	-0.4	0.7	0.6
Arm fat mass (right)	0.2	0.9	2.0	0.0	1.4	1.1	0.5
Trunk predicted mass	0.1	0.8	2.7	-0.1	-0.0	-0.7	-1.6
Standing height	0.1	0.8	2.2	-0.2	-1.5	-0.7	-0.8
Length of working week for main job	0.1	0.1	0.2	-0.4	-0.3	-0.1	0.3
Exposure to tobacco smoke at home	1.0	1.2	4.3	-0.6	0.1	0.2	-2.1
Breastfed as a baby	2.0	2.5	8.1	-1.4	-2.9	0.3	-0.2
Tense / ‘highly strung’	0.1	0.2	0.4	-0.1	-0.6	-0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.3	-0.5	0.2	-0.1	-1.8
Hair/balding pattern: Pattern 4	0.7	1.7	4.4	1.0	0.6	-1.1	-2.1
Birth weight of first child	0.2	0.3	0.8	0.9	-0.3	0.4	0.4
Peak expiratory flow (PEF)	0.6	1.3	2.6	0.4	-1.6	-1.0	-1.3
Pulse wave reflection index	3.3	4.0	7.4	-1.4	-0.0	2.7	2.6
Ever highly irritable/argumentative for 2 days	1.9	2.3	5.2	-2.3	-1.8	0.8	-0.1
Loud music exposure frequency	2.8	3.0	11.7	0.3	-0.5	3.4	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	0.3	-1.2	-0.6	0.1
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	4.3	0.5	-1.1	2.1	-1.5
Blood clot in the leg (DVT)	2.3	3.0	7.0	1.2	2.6	-0.8	-1.7
Medication: Paracetamol	1.5	2.4	7.0	-1.0	-1.1	2.6	0.8
Headache pain in last month	0.5	0.8	1.6	-1.2	-0.7	1.0	0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.1	0.3	-0.2	0.7	-1.0
Glaucoma (self-reported)	1.2	1.4	2.6	-0.5	-0.5	-1.6	-1.6
Gout (self-reported)	0.2	0.3	0.6	-0.0	-0.5	-0.6	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.7	-1.3	0.1	0.1	-0.6
Medication: Amlodipine	1.6	2.2	7.3	-0.8	-0.9	-0.3	2.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	0.1	-0.6	-0.7	0.1
Birth weight	0.1	0.3	0.7	-0.1	0.2	0.6	0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.0	0.2	-0.4	1.7	-0.4
High blood pressure (siblings)	3.8	5.4	11.9	1.2	2.8	0.7	-3.4
Forced vital capacity (FVC), Best measure	0.8	2.8	7.5	-0.8	-2.7	-1.1	1.4
Body fat percentage	0.4	1.7	2.5	-0.3	1.3	1.6	1.5
Leg fat percentage (right)	0.6	2.1	3.1	-0.8	1.4	1.7	1.8
Arm fat-free mass (right)	0.2	0.9	2.4	-1.0	-0.4	-0.2	-1.6
Exposure to tobacco smoke outside home	1.4	1.8	2.7	-1.6	-1.2	1.3	-1.2
Comparative body size at age 10	0.5	1.3	2.5	1.1	0.5	-1.0	-1.6
Number of full brothers	1.1	1.3	3.8	-1.2	0.3	1.9	0.3
Worry too long after embarrassment	0.8	1.4	3.5	1.3	-0.1	-0.7	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.3	-0.9	-0.5	0.7	-1.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	-0.8	-0.1	0.2	0.3
Number of children fathered	1.7	1.9	3.8	-1.7	-0.9	0.6	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.7	-0.7	-0.5	0.8	0.4
Age at first live birth	0.5	0.9	2.1	0.9	0.3	-0.7	-1.4
Pulse wave peak to peak time	1.2	1.4	2.1	1.4	0.1	-1.2	-1.4
Health satisfaction	0.8	1.1	2.4	-0.5	-1.5	0.4	-1.3
Shortness of breath walking on level ground	0.4	0.4	1.8	-1.3	-0.1	-0.1	-0.0
Qualifications: College or University degree	1.2	3.8	6.8	1.1	-1.2	-2.4	-2.6
Eye problems/disorders: None of the above	0.3	0.3	1.1	0.2	0.2	-1.0	0.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	4.2	0.5	-1.1	0.3	-2.0
Emphysema/chronic bronchitis	0.1	0.1	0.4	-0.4	-0.6	0.2	0.0
Medication for pain relief, constipation, heartburn	0.5	0.8	2.2	0.5	-0.6	-1.5	-0.6
Neck or shoulder pain in last month	0.3	0.4	1.1	0.2	-1.0	0.7	-0.1
Medication: Blood pressure	0.2	0.4	0.9	-0.6	0.2	-0.6	0.9
Angina (self-reported)	0.5	0.7	2.5	-1.6	0.4	0.3	-0.1
Migraine (self-reported)	0.5	0.6	0.9	0.1	-0.7	1.0	0.9
Medication: Ibuprofen	0.4	0.5	0.7	-0.5	0.7	0.7	0.9
Medication: Allopurinol	0.7	0.9	1.8	-0.1	-0.2	-1.4	-1.3
Medication: Omeprazole	0.6	0.7	2.1	-1.4	-0.3	-0.7	-0.3
Medication: Seretide 50 evohaler	0.3	0.4	0.8	-0.1	-0.9	-0.6	-0.6
Mean time to correctly identify matches	1.4	2.7	8.1	-0.1	2.8	0.4	-1.6
Heart disease (mother)	1.5	1.8	2.9	-0.7	1.2	1.6	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.9	-0.4	0.4	0.9	0.1
Whole body fat mass	0.2	0.8	1.4	-0.3	1.1	1.2	0.8
Leg fat mass (right)	0.3	1.2	2.0	-0.9	1.0	0.9	1.4
Arm predicted mass (right)	0.1	0.8	2.2	-0.8	-0.3	-0.3	-1.5
Pulse rate, automated reading	0.2	0.8	1.9	0.6	0.9	-1.4	-0.2
Alcohol intake frequency.	0.6	1.4	4.6	-0.6	2.1	0.8	0.0
Comparative height size at age 10	0.7	4.0	15.9	0.3	-0.0	0.1	-4.0
Number of full sisters	1.6	1.9	7.0	-0.3	0.8	-0.2	2.6
Suffer from ‘nerves’	0.5	0.8	1.5	-0.8	-1.2	0.2	-1.1
Overall health rating	0.3	0.6	0.8	-0.8	-0.9	0.5	-0.9
Chest pain or discomfort	1.4	2.0	5.4	0.2	-0.6	-1.4	-2.3
Had major operations	1.7	2.0	3.6	-1.9	-1.0	-1.8	-0.3
Age at last live birth	0.4	0.6	1.3	1.1	-0.2	0.9	0.0
Family relationship satisfaction	1.5	1.8	4.7	1.3	0.1	-1.0	-2.2
Leg pain on walking	1.0	1.2	2.2	-1.2	-1.0	0.4	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.0	0.9	-0.5	1.3	2.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.9	-0.9	1.4	0.1	1.1
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.3	0.6	-1.5	1.0	0.2
Medication: Aspirin	0.6	0.8	2.1	0.0	1.0	-1.4	-0.1
Supplements: Vitamin C	0.8	1.0	1.8	-1.2	-1.3	-0.8	0.1
Knee pain experienced in last month	0.9	1.5	2.8	1.7	1.2	1.0	-0.8
Hypertension (Self-reported)	0.3	0.9	1.9	0.5	1.4	0.2	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.2	-0.8	-0.4	-0.1	2.1
Illnesses of father: Heart disease	0.6	0.9	2.3	0.0	1.5	-0.9	-0.6
Illnesses of siblings: Diabetes	1.4	1.7	4.6	0.3	2.1	0.7	1.2
Smoking status: Previous	0.2	0.4	1.1	-0.5	0.3	0.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.4	-0.6	0.2	-0.4	0.0
Whole body fat-free mass	0.1	0.6	2.1	-0.3	-0.1	-0.5	-1.4
Leg fat-free mass (right)	0.1	0.5	1.5	-0.2	-0.2	-0.6	-1.2
Arm fat percentage (left)	0.4	1.6	3.0	0.4	1.7	1.5	1.1
Average weekly red wine intake	2.0	3.0	10.5	0.4	-0.9	-0.7	-3.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.5	-1.2	-0.8	-0.8	-0.1
Mood swings	0.3	0.5	1.0	-1.0	-0.7	-0.3	-0.5
Loneliness, isolation	0.5	0.7	2.5	0.3	-0.1	0.3	-1.6
Long-standing illness, disability or infirmity	0.6	0.9	2.1	-0.8	0.8	1.4	-0.5
Ever had bowel cancer screening	1.1	1.2	3.2	-0.3	-0.6	-1.1	-1.8
Diabetes diagnosed by doctor	1.1	1.8	4.4	-2.1	-1.1	-0.5	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.9	-0.8	-0.0	1.0	-0.8
Friendships satisfaction	0.3	0.4	0.8	0.9	-0.5	0.3	0.6
Qualifications: nursing, teaching	0.2	0.4	1.1	0.5	-1.1	-0.1	-0.2
Commuting to job workplace: Walk	2.3	2.5	4.6	2.1	1.9	1.4	-0.2
Eye problems/disorders: Cataract	0.1	0.2	0.3	-0.3	-0.4	0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.3	-0.5	0.8	0.4
Medication for cholesterol	0.2	0.3	0.8	-0.5	-0.1	-0.9	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.7	-1.6	-0.6	-0.4	0.5
Back pain experienced in last month	0.6	0.9	1.9	0.5	0.9	-0.7	-1.4
Mineral and other dietary supplements	0.7	0.9	1.6	0.5	1.1	0.9	1.3
Breast cancer (self-reported)	0.5	0.6	1.5	1.2	0.1	-0.7	-0.7
Asthma (self-reported)	0.1	0.3	0.9	-0.4	-0.1	-1.0	0.2
Osteoporosis (self-reported)	0.9	1.1	2.4	0.8	0.7	1.5	1.0
Osteoarthritis (self-reported)	0.1	0.1	0.4	-0.4	-0.1	-0.1	-0.6
Medication: Aspirin	0.5	0.6	1.3	-0.4	0.9	-1.1	0.1
Medication: Gliclazide	1.2	1.3	2.4	-1.3	-0.9	-0.7	-1.5
Illnesses of father: None of the above (group 1)	0.7	0.8	3.2	0.3	-1.8	-0.2	-0.2
Smoking status: Current	1.1	1.8	3.4	-1.1	-1.8	-1.0	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.2	0.6	-2.0	-0.4	-0.6
Whole body water mass	0.1	0.7	2.4	-0.2	-0.1	-0.4	-1.6
Leg predicted mass (right)	0.1	0.5	1.4	-0.2	-0.1	-0.7	-1.2
Arm fat mass (left)	0.3	1.0	2.2	0.0	1.5	1.4	0.4
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.3	0.8	0.4	0.7
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.3	0.4	-0.4	-0.7
Miserableness	0.6	1.1	3.6	0.3	-1.9	0.7	0.4
Guilty feelings	0.2	0.3	0.6	0.6	-0.6	0.1	-0.8
Wears glasses or contact lenses	2.8	3.2	7.5	-0.3	0.2	-2.2	-2.7
Ever taken oral contraceptive pill	1.9	2.1	7.3	-0.0	0.2	-2.7	1.1
Hearing aid user	1.3	1.5	3.1	-1.8	-0.8	0.3	-1.4
Mother’s age at death	1.9	2.3	4.5	-1.1	-2.1	0.9	1.6
Financial situation satisfaction	1.4	1.8	4.0	-2.0	-0.6	1.2	-1.1
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.0	0.6	0.7	-0.5	1.0
Commuting to job workplace: Public transport	1.1	1.3	4.7	0.7	-0.3	0.1	-2.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.0	-0.9	-0.0	-0.7	-1.0
Medication: Blood pressure	1.2	2.3	3.2	1.1	1.4	1.7	1.8
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.8	-0.9	0.1	0.5	-2.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	0.0	-1.2	-0.4	-0.4
High cholesterol (Self-reported)	1.1	1.9	7.3	-2.7	-0.1	-0.6	0.3
Medication: Bendroflumethiazide	0.7	1.0	1.6	-0.6	0.9	1.2	1.3
Medication: Paracetamol	0.9	1.4	4.5	-0.1	0.1	2.1	1.1
Medication: Lisinopril	0.5	0.7	1.7	0.8	1.3	0.3	-0.5
Medication: Atorvastatin	0.8	1.0	2.2	-0.6	1.1	0.6	-1.5
Illnesses of father: High blood pressure	1.9	2.4	4.5	-0.4	1.6	1.6	-2.1
Alcohol drinker status: Never	0.7	0.8	1.8	-0.9	-1.3	-0.8	0.3
Ever smoked	0.2	0.3	0.9	-0.0	0.2	-1.0	-0.4
Basal metabolic rate	0.1	0.4	1.3	-0.3	0.1	-0.2	-1.2
Leg fat percentage (left)	0.6	2.1	4.2	-1.2	0.8	1.4	2.0
Arm fat-free mass (left)	0.1	0.5	2.0	-0.4	-0.0	-0.2	-1.4
Number of operations (self-reported)	0.1	0.2	0.5	-0.2	-0.0	-0.7	-0.4
Average weekly beer plus cider intake	1.0	1.5	3.5	0.5	1.9	0.3	1.4
Irritability	0.4	0.7	1.7	-0.7	-0.1	-1.3	-0.8
Risk taking	0.4	0.5	1.5	-1.2	-0.3	0.3	0.7
Ever had prostate specific antigen (PSA) test	2.7	3.1	7.7	2.8	1.9	0.8	0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.4	0.9	0.3	-0.4
Age started oral contraceptive pill	2.3	2.9	5.9	1.9	2.4	-1.4	-0.3
Diastolic blood pressure, automated reading	0.5	1.5	3.0	0.6	1.5	1.7	0.6
Ever depressed for a whole week	1.2	1.5	3.2	1.8	0.4	0.7	-1.4
Unable to work because of sickness or disability	0.6	0.7	1.4	-1.2	1.2	0.2	-0.2
Commuting to job workplace: Cycle	1.0	1.3	2.2	0.5	0.7	1.5	-1.4
Myopia	0.4	0.6	2.2	0.4	0.2	-0.3	-1.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.9	-0.0	-1.4	0.0	-1.1
Cholesterol lowering medication	0.2	0.3	0.7	-0.8	0.4	0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	-1.6	-1.2	-0.2	0.1
Pain experienced in last month	0.1	0.1	0.2	0.0	0.2	-0.2	-0.5
Supplements: Calcium	0.3	0.3	0.7	-0.5	-0.3	-0.9	0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	-1.2	0.5	-0.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.3	-0.6	0.4	-1.1	1.5
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	7.1	1.3	2.7	-0.9	-1.3
Heart disease (siblings)	1.2	1.5	4.5	-0.8	2.1	0.7	-0.6
Alcohol drinker status: Previous	2.3	2.6	6.2	-0.2	2.5	2.0	0.3
Pack years of smoking	0.7	1.0	3.6	0.3	1.9	-0.1	0.7
Impedance of whole body	0.1	0.5	1.2	-0.3	-0.8	0.4	1.1
Leg fat mass (left)	0.3	1.2	2.4	-1.1	0.8	0.8	1.6
Arm predicted mass (left)	0.1	0.5	1.8	-0.5	0.0	-0.3	-1.3