Hub : Genes

WIZ

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.1180 0.0490 0.0054 0.020 NA 0.063 NA 0.064 0.03100 NA 0.00038 NA 0.00032
2 GTEx Breast Mammary Tissue (Female) 0.0864 0.0660 0.1200 -0.005 NA -0.009 NA -0.005 0.49000 NA 0.77000 NA 0.50000
3 GTEx Nerve Tibial 0.1144 0.0405 0.0010 -0.002 NA 0.007 NA -0.004 0.49000 NA 0.10000 NA 0.78000
4 TCGA Bladder Urothelial Carcinoma 0.0240 0.0140 0.0019 0.035 0.029 0.031 NA 0.027 0.00061 0.0016 0.00110 NA 0.00210

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 2.0 3.2 4.9 0.3 -2.0 1.9 2.2
Bipolar Disorder or Schizophrenia 1.3 3.2 9.0 1.3 -0.7 3.0 1.4
Depressed Affect (Nagel 2018) 0.2 0.5 1.5 -0.2 -0.6 1.2 -0.1
Depression (Nagel 2018) 0.3 0.4 0.6 -0.8 -0.5 0.6 -0.5
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.7 0.7 0.2 -1.3 -0.1
Neuroticism (Nagel 2018) 0.3 0.6 2.1 -0.3 0.0 0.4 -1.4
Schizophrenia (2018) 0.9 1.9 5.3 1.4 0.8 2.3 -0.1
Schizophrenia vs Biploar Disorder 0.3 0.4 0.8 0.6 0.0 -0.6 -0.9
Worry (Nagel 2018) 0.3 0.6 1.1 -0.8 -0.7 0.6 -1.0
Alzheimer’s Disease (in mother) 1.8 2.1 3.7 -1.3 -0.1 1.9 1.8
Alzheimer’s Disease (in father) 1.0 1.0 2.2 -0.6 -1.5 1.2 -0.5
Alzheimer’s Disease (including proxy) 0.9 1.3 3.0 -1.2 -0.6 1.7 0.6
Crohns Disease (2017) 3.3 7.2 21.9 -1.2 -2.2 0.8 -4.7
Irritable Bowel Disease (IBD) 1.8 4.3 14.1 0.2 -1.5 0.9 -3.8
Ulcerative Colitis (UC) 0.6 1.1 2.4 1.0 -0.9 -0.2 -1.5
Major Depression (MDD) 0.7 0.8 2.6 -0.6 -0.2 -0.7 -1.6
Reaction Time 1.8 3.4 9.7 0.6 3.1 0.7 -1.7
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.7 1.1 0.4 -0.7 1.3
Breast Cancer 0.2 0.6 1.3 -1.2 -0.4 0.9 -0.1
Ovarian Cancer 0.6 0.8 2.0 -1.4 -1.0 0.5 -0.2
Prostate Cancer 1.0 1.4 2.7 1.6 -1.1 -1.2 0.6
Age at First Birth 0.3 0.4 0.7 0.6 0.7 -0.1 0.8
Bipolar Disorder (2011) 0.5 0.5 1.6 -0.7 0.0 1.3 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 2.0 1.4 0.2 0.6 1.0
Coronary Artery Disease (CAD) 1.0 1.1 3.1 -1.8 0.0 0.9 0.8
Crohns Disease (2012) 3.1 5.0 13.6 -1.3 -2.1 0.5 -3.7
Mean Putamen Volume 0.3 0.4 1.1 0.6 1.1 -0.1 -0.3
Fasting Glucose 2.0 2.4 9.2 -0.3 -0.2 -0.4 3.0
HbA1C 0.6 0.6 1.6 -0.3 1.3 -0.9 0.2
HDL Cholesterol 0.7 1.2 2.8 0.1 1.7 1.3 -0.5
LDL Cholesterol 0.7 1.1 2.1 -0.2 -0.5 -1.4 -1.4
Lupus 1.0 1.4 5.3 0.4 -0.5 2.3 0.1
Neuroticism (2016) 0.2 0.3 1.2 -1.1 0.3 0.1 0.3
Primary Biliary Cirrhosis 1.0 1.4 4.3 -0.8 -2.1 0.4 0.7
Rheumatoid Arthritis 0.2 0.2 0.6 0.8 0.1 -0.5 0.0
Schizophrenia (2014) 1.1 2.5 6.1 1.8 0.8 2.5 -0.5
Triglycerides 0.1 0.2 0.5 -0.2 -0.7 -0.3 -0.0
Type 2 Diabetes (T2D) (2012) 4.3 4.9 9.2 1.2 2.3 -1.9 3.0
Ulcerative Colitis 0.6 0.9 2.8 0.9 -0.4 0.1 -1.7
Blood Eosinophil Count 0.1 1.1 1.5 1.2 1.1 0.7 1.0
Blood Platelet Count 0.7 8.4 31.2 -1.1 -0.7 -0.7 -5.6
Blood Red Count 0.6 6.2 10.4 1.9 2.8 1.7 -3.2
Blood White Count 0.1 0.4 1.5 0.0 -0.2 -0.1 -1.2
Heel T-Score 0.2 1.5 2.3 -0.1 1.5 1.2 1.4
BMI 0.4 2.1 5.2 1.1 2.3 1.2 0.8
Height 0.1 2.2 7.4 0.5 -1.1 -0.0 -2.7
Waist Hip Ratio (WHR) 0.7 3.1 10.8 0.1 0.2 1.3 3.3
Systolic Blood Pressure 0.1 0.4 1.6 -0.2 -0.1 -1.3 0.3
Smoking Status 0.4 0.8 1.2 -0.5 -1.1 -1.1 0.9
Allergy or Eczema 0.5 1.3 3.2 1.8 -0.8 0.6 -1.0
Cardiovascular Disease 0.5 1.6 1.7 1.3 1.1 1.3 1.2
Hypothyroidism (self reported) 0.2 0.4 1.4 -1.2 -0.2 0.3 0.4
Respiratory disease 0.5 1.1 2.4 -1.1 -1.6 -0.8 0.3
Type 2 Diabetes (T2D) (2018) 0.7 1.3 3.3 -1.8 -1.0 -0.5 0.7
Lung FEV1/FVC ratio 0.1 0.3 0.5 0.4 -0.6 -0.5 -0.7
Lung FVC 0.3 1.7 5.0 -0.8 -2.2 0.4 1.1
Neuroticism 0.2 0.5 1.7 0.1 -0.2 0.3 -1.3
Chronotype (morning person) 0.5 1.3 3.1 -0.7 -0.9 0.9 -1.8
Hair Pigment 0.1 2.0 5.8 -0.4 -0.9 -1.1 2.4
Tanning 0.2 1.9 3.1 -1.6 -1.2 -1.8 0.7
Hand grip strength (left) 0.2 0.5 1.0 -0.3 -1.0 -0.2 0.9
Number of treatments/medications taken 0.0 0.1 0.2 -0.3 0.4 0.2 -0.2
Average weekly spirits intake 0.6 0.8 2.3 -0.7 0.5 -1.5 0.0
Sensitivity / hurt feelings 0.4 0.7 1.3 1.1 -0.4 -0.8 -0.7
Frequency of depressed mood in last 2 weeks 1.2 1.7 2.4 -1.2 -1.5 0.8 -1.5
Hearing difficulty/problems: Yes 0.7 1.0 2.5 -0.7 0.8 1.6 -0.6
Relative age of first facial hair 0.3 0.7 2.3 0.3 -0.5 -0.2 1.5
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 2.7 -1.2 -1.0 -0.9 -1.6
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.2 -0.5 0.2 -0.2 -1.1
Ever had hysterectomy (womb removed) 1.4 1.5 5.3 -0.1 0.6 2.3 -0.7
Systolic blood pressure, automated reading 0.1 0.3 0.7 -0.5 0.5 -0.8 -0.4
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.7 -0.3 1.3 0.6 0.7
Angina 0.4 0.6 2.2 -1.5 0.2 0.2 -0.1
Medication for hormone replacement therapy 1.5 1.6 5.7 -0.4 -0.4 -0.7 -2.4
Vitamin and mineral supplements 0.9 1.2 2.9 0.9 1.1 0.2 1.7
Supplements: Zinc 0.4 0.4 1.4 -0.3 -0.5 -0.2 -1.2
Medication: Co-codamol 0.4 0.4 1.3 -0.3 0.6 -1.2 -0.0
Medication: Metformin 0.3 0.5 1.3 -1.1 -0.1 -0.2 0.7
Diabetes (father) 0.9 1.1 2.0 1.1 1.4 -0.6 -0.9
Diabetes (mother) 1.6 2.0 4.8 2.2 1.5 -0.4 1.0
Severe depression (siblings) 0.6 0.6 1.0 -1.0 0.5 -0.6 -0.9
Pack years adult smoking proportion 0.5 0.8 2.6 -0.1 1.6 -0.3 0.6
Impedance of leg (right) 0.2 0.9 2.0 -0.9 -0.7 0.6 1.4
Leg fat-free mass (left) 0.1 0.4 1.3 -0.1 0.1 -0.4 -1.1
Trunk fat percentage 0.4 1.4 2.3 -0.3 1.0 1.5 1.5
Hand grip strength (right) 0.2 0.6 2.2 -0.1 -1.5 0.2 0.3
Townsend deprivation index at recruitment 0.7 1.0 3.3 -0.2 -0.2 0.7 -1.8
Current tobacco smoking 1.1 1.8 3.0 -1.4 -1.7 -1.3 -0.8
Average weekly fortified wine intake 0.6 0.7 2.2 1.5 -0.2 0.0 -0.8
Maternal smoking around birth 0.6 0.8 2.1 -0.0 1.4 1.0 0.6
Fed-up feelings 0.1 0.2 0.4 0.3 -0.4 0.6 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.0 0.3 0.2 1.0 -0.6
Relative age voice broke 1.3 2.0 4.0 -2.0 -1.0 0.4 1.7
Taking other prescription medications 1.1 1.6 3.4 -1.8 -1.5 -0.9 -0.1
Age when periods started (menarche) 3.4 8.1 25.5 0.1 -2.3 1.3 5.0
Bilateral oophorectomy (both ovaries removed) 1.8 2.0 2.9 1.6 1.4 1.7 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 2.0 0.5 1.4 0.3 0.8
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.6 0.1 -1.2 -0.4 -0.6
Qualifications: CSEs or equivalent 4.9 6.5 16.4 2.8 1.3 4.0 0.2
Serious illness, injury or assault to yourself 1.1 1.3 4.6 -0.7 0.4 -2.1 -0.1
High blood pressure 0.3 0.8 2.0 0.7 1.4 0.3 0.8
Hayfever, allergic rhinitis or eczema 0.9 2.0 4.7 1.5 -1.1 0.1 -2.2
Multivitamins +/- minerals 0.9 1.1 1.8 -1.3 -1.0 0.1 -1.3
Stomach or abdominal pain in last month 1.1 1.3 2.3 -0.4 0.8 1.5 -1.5
Supplements: Glucosamine 0.6 0.8 2.9 -0.0 -1.7 0.0 -0.4
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 3.3 -0.2 -0.8 -1.8 -0.0
Medication: Atenolol 0.3 0.3 0.7 -0.5 -0.3 -0.5 0.8
Medication: Levothyroxine sodium 0.2 0.4 1.4 -1.2 0.1 0.0 -0.3
Sitting height 0.3 2.0 5.8 -0.6 -1.3 -0.3 -2.4
Chronic bronchitis/emphysema (father) 1.0 1.2 3.2 1.2 0.1 0.4 1.8
High blood pressure (mother) 0.6 0.8 2.9 1.7 0.4 -0.3 -0.3
Body mass index (BMI) 0.2 1.0 2.3 -0.0 1.5 1.1 0.5
Impedance of leg (left) 0.4 1.9 3.1 -1.6 -1.4 0.1 1.8
Leg predicted mass (left) 0.1 0.4 1.3 -0.1 0.1 -0.4 -1.1
Trunk fat mass 0.2 1.0 1.8 -0.3 1.0 1.3 1.1
Waist circumference 0.4 1.6 2.5 -0.2 1.4 1.6 1.4
Number of incorrect matches in round 0.4 0.6 1.2 0.6 0.5 1.1 0.8
Past tobacco smoking 0.0 0.0 0.1 0.1 0.0 0.1 -0.2
Alcohol usually taken with meals 1.5 2.5 6.6 1.2 1.3 0.0 -2.6
Nervous feelings 0.6 1.2 3.2 -1.1 -1.8 -0.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.9 0.2 -0.7 0.6 -0.9
Hearing difficulty/problems with background noise 0.4 0.6 1.4 -0.6 0.4 0.7 -1.2
Hair/balding pattern: Pattern 2 0.5 0.6 2.0 0.3 1.4 0.5 -0.4
Had menopause 1.0 1.3 2.1 -1.4 -1.4 -0.4 -1.0
Had other major operations 1.5 1.8 5.9 1.1 0.5 0.2 -2.4
Forced vital capacity (FVC) 0.6 2.2 6.8 -0.7 -2.6 0.3 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.4 1.1 1.6 0.2 0.6
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.1 0.7 1.0 0.3 -0.5
Qualifications: None of the above 0.3 0.6 1.9 -1.4 0.5 -0.2 0.5
Financial difficulties in last 2 years 0.4 0.6 1.2 -0.6 0.5 1.1 -0.8
Mouth/teeth dental problems 1.2 1.8 4.3 0.5 2.1 -1.6 -0.3
Heart attack 0.9 1.1 2.1 -0.6 0.4 -1.4 1.3
Allergy 0.6 1.4 4.4 -0.8 0.3 -0.6 2.1
Pain all over the body in last month 2.4 2.6 5.7 -2.4 -1.3 -1.7 -0.3
Diabetes (self-reported) 0.5 0.8 2.8 -1.7 -0.4 -0.2 0.4
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 5.0 -0.0 -1.6 0.7 -2.2
Medication: Ramipril 0.3 0.4 0.7 0.6 0.0 0.6 0.8
Medication: Simvastatin 1.1 1.6 3.2 -1.6 -0.7 0.4 1.8
Fluid intelligence score 1.0 2.0 4.4 1.7 0.2 -2.1 0.9
Illnesses of siblings 2.9 4.0 6.5 -0.2 -2.5 -2.6 1.8
Neuroticism score 0.3 0.6 2.1 -0.2 -0.6 0.1 -1.4
Weight 0.1 0.3 0.6 -0.2 0.8 0.7 0.0
Impedance of arm (right) 0.2 0.8 2.0 1.4 -0.2 0.4 0.9
Arm fat percentage (right) 0.5 1.9 3.8 0.6 1.9 1.4 1.2
Trunk fat-free mass 0.1 0.7 2.3 -0.2 -0.1 -0.6 -1.5
Hip circumference 0.1 0.6 1.2 -0.1 1.1 1.1 -0.4
Time employed in main current job 0.1 0.2 0.3 -0.4 -0.6 -0.3 -0.2
Alcohol intake versus 10 years previously 0.2 0.3 0.7 -0.9 0.3 -0.4 -0.4
Father’s age at death 0.7 0.9 2.1 1.1 -0.6 0.0 1.5
Worrier / anxious feelings 0.8 1.5 4.9 -0.3 -0.6 0.9 -2.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.6 0.1 0.2 -0.9 -1.3
Falls in the last year 0.3 0.4 1.6 -0.3 -0.3 -1.3 0.0
Hair/balding pattern: Pattern 3 1.1 1.6 6.2 0.0 -0.2 2.5 -0.5
Number of live births 2.1 3.0 6.2 1.4 -0.2 2.5 1.9
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 7.5 -0.6 -2.7 0.3 0.7
Pulse rate 0.7 1.1 2.5 -1.0 -0.6 -1.6 -0.9
Happiness 0.8 1.0 2.5 -0.2 -1.6 -0.6 -1.0
Noisy workplace 0.1 0.2 0.3 -0.2 -0.6 0.0 -0.6
Qualifications: A levels/AS levels or equivalent 1.8 3.9 6.3 2.3 -0.5 -2.5 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.3 -0.1 1.1 -1.1 0.7
Mouth/teeth dental problems: Dentures 1.6 2.7 5.6 -1.3 -0.3 1.9 2.4
Asthma 0.1 0.2 0.7 -0.4 -0.0 -0.9 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.3 -1.1 0.0 1.1 0.6
Medication: Cholesterol lowering 0.5 0.7 1.7 -1.0 -0.4 -0.0 1.3
Depression (self-reported) 0.6 0.7 2.3 1.5 0.1 0.5 -0.2
Medication: Lansoprazole 1.6 1.8 6.0 -2.4 -0.4 0.8 0.5
Prospective memory result 0.2 0.3 0.4 -0.6 0.2 0.6 0.6
Lung cancer (father) 0.3 0.4 0.7 0.1 0.4 0.8 -0.8
Illnesses of mother 0.8 0.9 2.4 -0.5 0.1 -1.5 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 6.9 -0.6 -2.6 -0.8 0.8
Pulse wave Arterial Stiffness index 0.9 1.1 1.8 -1.2 -0.2 1.0 1.4
Impedance of arm (left) 0.1 0.4 0.5 0.7 -0.4 0.7 0.6
Arm fat mass (right) 0.2 0.9 2.0 0.0 1.4 1.1 0.5
Trunk predicted mass 0.1 0.8 2.7 -0.1 -0.0 -0.7 -1.6
Standing height 0.1 0.8 2.2 -0.2 -1.5 -0.7 -0.8
Length of working week for main job 0.1 0.1 0.2 -0.4 -0.3 -0.1 0.3
Exposure to tobacco smoke at home 1.0 1.2 4.3 -0.6 0.1 0.2 -2.1
Breastfed as a baby 2.0 2.5 8.1 -1.4 -2.9 0.3 -0.2
Tense / ‘highly strung’ 0.1 0.2 0.4 -0.1 -0.6 -0.3 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 3.3 -0.5 0.2 -0.1 -1.8
Hair/balding pattern: Pattern 4 0.7 1.7 4.4 1.0 0.6 -1.1 -2.1
Birth weight of first child 0.2 0.3 0.8 0.9 -0.3 0.4 0.4
Peak expiratory flow (PEF) 0.6 1.3 2.6 0.4 -1.6 -1.0 -1.3
Pulse wave reflection index 3.3 4.0 7.4 -1.4 -0.0 2.7 2.6
Ever highly irritable/argumentative for 2 days 1.9 2.3 5.2 -2.3 -1.8 0.8 -0.1
Loud music exposure frequency 2.8 3.0 11.7 0.3 -0.5 3.4 -0.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.5 0.3 -1.2 -0.6 0.1
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 4.3 0.5 -1.1 2.1 -1.5
Blood clot in the leg (DVT) 2.3 3.0 7.0 1.2 2.6 -0.8 -1.7
Medication: Paracetamol 1.5 2.4 7.0 -1.0 -1.1 2.6 0.8
Headache pain in last month 0.5 0.8 1.6 -1.2 -0.7 1.0 0.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.4 1.1 0.3 -0.2 0.7 -1.0
Glaucoma (self-reported) 1.2 1.4 2.6 -0.5 -0.5 -1.6 -1.6
Gout (self-reported) 0.2 0.3 0.6 -0.0 -0.5 -0.6 -0.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.7 -1.3 0.1 0.1 -0.6
Medication: Amlodipine 1.6 2.2 7.3 -0.8 -0.9 -0.3 2.7
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.4 0.1 -0.6 -0.7 0.1
Birth weight 0.1 0.3 0.7 -0.1 0.2 0.6 0.8
Chronic bronchitis/emphysema (mother) 0.7 0.8 3.0 0.2 -0.4 1.7 -0.4
High blood pressure (siblings) 3.8 5.4 11.9 1.2 2.8 0.7 -3.4
Forced vital capacity (FVC), Best measure 0.8 2.8 7.5 -0.8 -2.7 -1.1 1.4
Body fat percentage 0.4 1.7 2.5 -0.3 1.3 1.6 1.5
Leg fat percentage (right) 0.6 2.1 3.1 -0.8 1.4 1.7 1.8
Arm fat-free mass (right) 0.2 0.9 2.4 -1.0 -0.4 -0.2 -1.6
Exposure to tobacco smoke outside home 1.4 1.8 2.7 -1.6 -1.2 1.3 -1.2
Comparative body size at age 10 0.5 1.3 2.5 1.1 0.5 -1.0 -1.6
Number of full brothers 1.1 1.3 3.8 -1.2 0.3 1.9 0.3
Worry too long after embarrassment 0.8 1.4 3.5 1.3 -0.1 -0.7 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.3 -0.9 -0.5 0.7 -1.5
Wheeze or whistling in the chest in last year 0.1 0.2 0.7 -0.8 -0.1 0.2 0.3
Number of children fathered 1.7 1.9 3.8 -1.7 -0.9 0.6 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.7 -0.7 -0.5 0.8 0.4
Age at first live birth 0.5 0.9 2.1 0.9 0.3 -0.7 -1.4
Pulse wave peak to peak time 1.2 1.4 2.1 1.4 0.1 -1.2 -1.4
Health satisfaction 0.8 1.1 2.4 -0.5 -1.5 0.4 -1.3
Shortness of breath walking on level ground 0.4 0.4 1.8 -1.3 -0.1 -0.1 -0.0
Qualifications: College or University degree 1.2 3.8 6.8 1.1 -1.2 -2.4 -2.6
Eye problems/disorders: None of the above 0.3 0.3 1.1 0.2 0.2 -1.0 0.2
Mouth/teeth dental problems: Loose teeth 1.2 1.4 4.2 0.5 -1.1 0.3 -2.0
Emphysema/chronic bronchitis 0.1 0.1 0.4 -0.4 -0.6 0.2 0.0
Medication for pain relief, constipation, heartburn 0.5 0.8 2.2 0.5 -0.6 -1.5 -0.6
Neck or shoulder pain in last month 0.3 0.4 1.1 0.2 -1.0 0.7 -0.1
Medication: Blood pressure 0.2 0.4 0.9 -0.6 0.2 -0.6 0.9
Angina (self-reported) 0.5 0.7 2.5 -1.6 0.4 0.3 -0.1
Migraine (self-reported) 0.5 0.6 0.9 0.1 -0.7 1.0 0.9
Medication: Ibuprofen 0.4 0.5 0.7 -0.5 0.7 0.7 0.9
Medication: Allopurinol 0.7 0.9 1.8 -0.1 -0.2 -1.4 -1.3
Medication: Omeprazole 0.6 0.7 2.1 -1.4 -0.3 -0.7 -0.3
Medication: Seretide 50 evohaler 0.3 0.4 0.8 -0.1 -0.9 -0.6 -0.6
Mean time to correctly identify matches 1.4 2.7 8.1 -0.1 2.8 0.4 -1.6
Heart disease (mother) 1.5 1.8 2.9 -0.7 1.2 1.6 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.9 -0.4 0.4 0.9 0.1
Whole body fat mass 0.2 0.8 1.4 -0.3 1.1 1.2 0.8
Leg fat mass (right) 0.3 1.2 2.0 -0.9 1.0 0.9 1.4
Arm predicted mass (right) 0.1 0.8 2.2 -0.8 -0.3 -0.3 -1.5
Pulse rate, automated reading 0.2 0.8 1.9 0.6 0.9 -1.4 -0.2
Alcohol intake frequency. 0.6 1.4 4.6 -0.6 2.1 0.8 0.0
Comparative height size at age 10 0.7 4.0 15.9 0.3 -0.0 0.1 -4.0
Number of full sisters 1.6 1.9 7.0 -0.3 0.8 -0.2 2.6
Suffer from ‘nerves’ 0.5 0.8 1.5 -0.8 -1.2 0.2 -1.1
Overall health rating 0.3 0.6 0.8 -0.8 -0.9 0.5 -0.9
Chest pain or discomfort 1.4 2.0 5.4 0.2 -0.6 -1.4 -2.3
Had major operations 1.7 2.0 3.6 -1.9 -1.0 -1.8 -0.3
Age at last live birth 0.4 0.6 1.3 1.1 -0.2 0.9 0.0
Family relationship satisfaction 1.5 1.8 4.7 1.3 0.1 -1.0 -2.2
Leg pain on walking 1.0 1.2 2.2 -1.2 -1.0 0.4 -1.5
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 4.0 0.9 -0.5 1.3 2.0
Commuting to job workplace: Car/motor vehicle 0.9 1.0 1.9 -0.9 1.4 0.1 1.1
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.3 0.6 -1.5 1.0 0.2
Medication: Aspirin 0.6 0.8 2.1 0.0 1.0 -1.4 -0.1
Supplements: Vitamin C 0.8 1.0 1.8 -1.2 -1.3 -0.8 0.1
Knee pain experienced in last month 0.9 1.5 2.8 1.7 1.2 1.0 -0.8
Hypertension (Self-reported) 0.3 0.9 1.9 0.5 1.4 0.2 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 4.2 -0.8 -0.4 -0.1 2.1
Illnesses of father: Heart disease 0.6 0.9 2.3 0.0 1.5 -0.9 -0.6
Illnesses of siblings: Diabetes 1.4 1.7 4.6 0.3 2.1 0.7 1.2
Smoking status: Previous 0.2 0.4 1.1 -0.5 0.3 0.1 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.4 -0.6 0.2 -0.4 0.0
Whole body fat-free mass 0.1 0.6 2.1 -0.3 -0.1 -0.5 -1.4
Leg fat-free mass (right) 0.1 0.5 1.5 -0.2 -0.2 -0.6 -1.2
Arm fat percentage (left) 0.4 1.6 3.0 0.4 1.7 1.5 1.1
Average weekly red wine intake 2.0 3.0 10.5 0.4 -0.9 -0.7 -3.2
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.5 -1.2 -0.8 -0.8 -0.1
Mood swings 0.3 0.5 1.0 -1.0 -0.7 -0.3 -0.5
Loneliness, isolation 0.5 0.7 2.5 0.3 -0.1 0.3 -1.6
Long-standing illness, disability or infirmity 0.6 0.9 2.1 -0.8 0.8 1.4 -0.5
Ever had bowel cancer screening 1.1 1.2 3.2 -0.3 -0.6 -1.1 -1.8
Diabetes diagnosed by doctor 1.1 1.8 4.4 -2.1 -1.1 -0.5 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.9 -0.8 -0.0 1.0 -0.8
Friendships satisfaction 0.3 0.4 0.8 0.9 -0.5 0.3 0.6
Qualifications: nursing, teaching 0.2 0.4 1.1 0.5 -1.1 -0.1 -0.2
Commuting to job workplace: Walk 2.3 2.5 4.6 2.1 1.9 1.4 -0.2
Eye problems/disorders: Cataract 0.1 0.2 0.3 -0.3 -0.4 0.3 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 0.3 -0.5 0.8 0.4
Medication for cholesterol 0.2 0.3 0.8 -0.5 -0.1 -0.9 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 2.7 -1.6 -0.6 -0.4 0.5
Back pain experienced in last month 0.6 0.9 1.9 0.5 0.9 -0.7 -1.4
Mineral and other dietary supplements 0.7 0.9 1.6 0.5 1.1 0.9 1.3
Breast cancer (self-reported) 0.5 0.6 1.5 1.2 0.1 -0.7 -0.7
Asthma (self-reported) 0.1 0.3 0.9 -0.4 -0.1 -1.0 0.2
Osteoporosis (self-reported) 0.9 1.1 2.4 0.8 0.7 1.5 1.0
Osteoarthritis (self-reported) 0.1 0.1 0.4 -0.4 -0.1 -0.1 -0.6
Medication: Aspirin 0.5 0.6 1.3 -0.4 0.9 -1.1 0.1
Medication: Gliclazide 1.2 1.3 2.4 -1.3 -0.9 -0.7 -1.5
Illnesses of father: None of the above (group 1) 0.7 0.8 3.2 0.3 -1.8 -0.2 -0.2
Smoking status: Current 1.1 1.8 3.4 -1.1 -1.8 -1.0 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 4.2 0.6 -2.0 -0.4 -0.6
Whole body water mass 0.1 0.7 2.4 -0.2 -0.1 -0.4 -1.6
Leg predicted mass (right) 0.1 0.5 1.4 -0.2 -0.1 -0.7 -1.2
Arm fat mass (left) 0.3 1.0 2.2 0.0 1.5 1.4 0.4
Number of self-reported non-cancer illnesses 0.2 0.3 0.6 -0.3 0.8 0.4 0.7
Average weekly champagne plus white wine intake 0.2 0.2 0.5 0.3 0.4 -0.4 -0.7
Miserableness 0.6 1.1 3.6 0.3 -1.9 0.7 0.4
Guilty feelings 0.2 0.3 0.6 0.6 -0.6 0.1 -0.8
Wears glasses or contact lenses 2.8 3.2 7.5 -0.3 0.2 -2.2 -2.7
Ever taken oral contraceptive pill 1.9 2.1 7.3 -0.0 0.2 -2.7 1.1
Hearing aid user 1.3 1.5 3.1 -1.8 -0.8 0.3 -1.4
Mother’s age at death 1.9 2.3 4.5 -1.1 -2.1 0.9 1.6
Financial situation satisfaction 1.4 1.8 4.0 -2.0 -0.6 1.2 -1.1
Tinnitus: Yes, now most or all of the time 0.5 0.5 1.0 0.6 0.7 -0.5 1.0
Commuting to job workplace: Public transport 1.1 1.3 4.7 0.7 -0.3 0.1 -2.2
Eye problems/disorders: Glaucoma 0.5 0.6 1.0 -0.9 -0.0 -0.7 -1.0
Medication: Blood pressure 1.2 2.3 3.2 1.1 1.4 1.7 1.8
Pain type(s) experienced in last month: Hip pain 1.0 1.2 3.8 -0.9 0.1 0.5 -2.0
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.4 0.0 -1.2 -0.4 -0.4
High cholesterol (Self-reported) 1.1 1.9 7.3 -2.7 -0.1 -0.6 0.3
Medication: Bendroflumethiazide 0.7 1.0 1.6 -0.6 0.9 1.2 1.3
Medication: Paracetamol 0.9 1.4 4.5 -0.1 0.1 2.1 1.1
Medication: Lisinopril 0.5 0.7 1.7 0.8 1.3 0.3 -0.5
Medication: Atorvastatin 0.8 1.0 2.2 -0.6 1.1 0.6 -1.5
Illnesses of father: High blood pressure 1.9 2.4 4.5 -0.4 1.6 1.6 -2.1
Alcohol drinker status: Never 0.7 0.8 1.8 -0.9 -1.3 -0.8 0.3
Ever smoked 0.2 0.3 0.9 -0.0 0.2 -1.0 -0.4
Basal metabolic rate 0.1 0.4 1.3 -0.3 0.1 -0.2 -1.2
Leg fat percentage (left) 0.6 2.1 4.2 -1.2 0.8 1.4 2.0
Arm fat-free mass (left) 0.1 0.5 2.0 -0.4 -0.0 -0.2 -1.4
Number of operations (self-reported) 0.1 0.2 0.5 -0.2 -0.0 -0.7 -0.4
Average weekly beer plus cider intake 1.0 1.5 3.5 0.5 1.9 0.3 1.4
Irritability 0.4 0.7 1.7 -0.7 -0.1 -1.3 -0.8
Risk taking 0.4 0.5 1.5 -1.2 -0.3 0.3 0.7
Ever had prostate specific antigen (PSA) test 2.7 3.1 7.7 2.8 1.9 0.8 0.8
Fractured/broken bones in last 5 years 0.2 0.3 0.7 0.4 0.9 0.3 -0.4
Age started oral contraceptive pill 2.3 2.9 5.9 1.9 2.4 -1.4 -0.3
Diastolic blood pressure, automated reading 0.5 1.5 3.0 0.6 1.5 1.7 0.6
Ever depressed for a whole week 1.2 1.5 3.2 1.8 0.4 0.7 -1.4
Unable to work because of sickness or disability 0.6 0.7 1.4 -1.2 1.2 0.2 -0.2
Commuting to job workplace: Cycle 1.0 1.3 2.2 0.5 0.7 1.5 -1.4
Myopia 0.4 0.6 2.2 0.4 0.2 -0.3 -1.5
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.9 -0.0 -1.4 0.0 -1.1
Cholesterol lowering medication 0.2 0.3 0.7 -0.8 0.4 0.3 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.5 -1.6 -1.2 -0.2 0.1
Pain experienced in last month 0.1 0.1 0.2 0.0 0.2 -0.2 -0.5
Supplements: Calcium 0.3 0.3 0.7 -0.5 -0.3 -0.9 0.1
Basal cell carcinoma (self-reported) 0.4 0.5 1.3 -1.2 0.5 -0.2 -0.6
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.3 -0.6 0.4 -1.1 1.5
Deep venous thrombosis (DVT) (self-reported) 2.2 2.8 7.1 1.3 2.7 -0.9 -1.3
Heart disease (siblings) 1.2 1.5 4.5 -0.8 2.1 0.7 -0.6
Alcohol drinker status: Previous 2.3 2.6 6.2 -0.2 2.5 2.0 0.3
Pack years of smoking 0.7 1.0 3.6 0.3 1.9 -0.1 0.7
Impedance of whole body 0.1 0.5 1.2 -0.3 -0.8 0.4 1.1
Leg fat mass (left) 0.3 1.2 2.4 -1.1 0.8 0.8 1.6
Arm predicted mass (left) 0.1 0.5 1.8 -0.5 0.0 -0.3 -1.3