Hub : Genes

XKR8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1129	0.0309	4.2e-12	0.096	0.094	0.105	0.093	0.108	3.2e-14	6.1e-14	2.2e-15	8.3e-14	6.9e-16
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0369	0.0189	3.5e-03	0.006	0.010	0.021	NA	0.016	6.8e-02	2.2e-02	1.7e-03	NA	6.3e-03
3	TCGA	Thyroid Carcinoma	0.0800	0.0360	1.2e-04	0.024	0.043	0.038	NA	0.039	1.9e-03	4.3e-05	1.3e-04	NA	1.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.3	0.6	0.5	0.3
Bipolar Disorder or Schizophrenia	0.5	1.3	2.8	-1.7	0.6	-0.9
Depressed Affect (Nagel 2018)	0.6	1.3	2.9	-1.7	-1.0	-0.4
Depression (Nagel 2018)	0.5	0.7	1.6	-1.3	0.8	-0.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.1	1.4	0.6	-0.3
Neuroticism (Nagel 2018)	0.3	0.7	2.0	-1.4	-0.0	-0.1
Schizophrenia (2018)	1.4	2.8	6.6	-2.6	0.3	-1.4
Schizophrenia vs Biploar Disorder	0.5	0.6	1.7	-1.3	-0.3	0.0
Worry (Nagel 2018)	0.3	0.6	1.0	-0.8	1.0	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.7	0.1	0.4
Alzheimer’s Disease (in father)	2.1	2.3	4.3	2.1	1.5	-0.4
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.8	0.3	-0.4
Crohns Disease (2017)	1.7	3.6	8.8	3.0	1.4	-0.5
Irritable Bowel Disease (IBD)	1.8	4.2	8.7	3.0	2.0	-0.3
Ulcerative Colitis (UC)	1.0	1.9	3.2	1.8	1.6	0.1
Major Depression (MDD)	0.6	0.7	1.6	-1.3	0.4	-0.5
Reaction Time	0.2	0.4	0.8	-0.4	0.5	0.9
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.5	1.6	-0.5	0.4
Breast Cancer	0.2	0.4	0.8	-0.5	0.4	-0.9
Ovarian Cancer	0.2	0.3	0.5	0.2	0.6	-0.7
Prostate Cancer	0.6	0.8	1.2	1.1	1.1	0.1
Age at First Birth	0.5	0.7	1.2	-1.1	0.9	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	3.7	1.9	0.2	0.0
Coronary Artery Disease (CAD)	0.7	0.8	1.4	0.7	0.7	-1.2
Crohns Disease (2012)	0.9	1.4	3.4	0.7	0.6	-1.8
Mean Putamen Volume	0.3	0.4	1.0	0.2	1.0	0.3
Fasting Glucose	0.4	0.5	0.8	-0.8	-0.3	-0.9
HbA1C	1.7	1.9	3.3	0.5	-1.8	1.4
HDL Cholesterol	0.2	0.3	0.7	-0.8	0.1	-0.4
LDL Cholesterol	1.2	1.9	3.4	-1.4	0.6	-1.9
Lupus	0.5	0.7	1.3	-0.5	-1.2	0.8
Neuroticism (2016)	0.5	0.7	1.7	-0.4	1.3	-0.2
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.0	0.3	-0.4
Rheumatoid Arthritis	1.3	1.8	3.8	-0.3	1.3	-1.9
Schizophrenia (2014)	1.0	2.3	5.8	-2.4	0.5	-1.0
Triglycerides	0.1	0.2	0.6	-0.8	0.1	0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	-0.3	-0.3	-1.2
Ulcerative Colitis	1.1	1.7	2.6	1.4	1.6	-0.7
Blood Eosinophil Count	0.5	3.8	11.1	3.3	-0.4	-0.3
Blood Platelet Count	1.6	18.7	52.3	7.2	-1.7	1.0
Blood Red Count	0.9	8.6	16.6	4.1	-0.1	3.0
Blood White Count	0.7	5.0	13.5	3.7	-0.9	0.8
Heel T-Score	0.5	3.6	5.4	1.3	-2.3	1.9
BMI	0.5	2.8	5.7	1.6	-0.4	2.4
Height	0.1	2.1	5.2	-0.7	0.7	-2.3
Waist Hip Ratio (WHR)	0.0	0.2	0.5	-0.7	0.0	-0.2
Systolic Blood Pressure	0.2	0.9	1.8	1.4	-1.0	0.2
Smoking Status	0.4	0.9	2.4	-0.5	-1.6	-0.2
Allergy or Eczema	0.2	0.5	0.9	0.0	-0.7	-1.0
Cardiovascular Disease	0.4	1.2	2.5	1.6	-1.0	0.3
Hypothyroidism (self reported)	0.3	0.7	1.4	-1.2	-0.7	-0.4
Respiratory disease	0.1	0.2	0.4	-0.7	0.2	-0.1
Type 2 Diabetes (T2D) (2018)	1.3	2.4	6.2	-0.8	-2.5	-0.6
Lung FEV1/FVC ratio	0.5	2.8	5.2	1.7	-2.3	0.2
Lung FVC	0.5	2.5	4.6	-2.1	0.5	-1.6
Neuroticism	0.6	1.5	3.6	-1.9	-0.7	-0.6
Chronotype (morning person)	1.5	3.4	4.9	-0.9	2.1	-2.2
Hair Pigment	0.0	1.0	2.7	0.5	-0.0	-1.6
Tanning	0.1	1.1	1.9	1.4	0.6	1.0
Hand grip strength (left)	0.3	0.8	1.0	1.0	-0.7	0.9
Number of treatments/medications taken	0.1	0.1	0.2	0.5	-0.4	-0.1
Average weekly spirits intake	0.4	0.6	1.7	-1.3	-0.0	0.1
Sensitivity / hurt feelings	0.1	0.2	0.7	-0.8	0.2	0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.2	-0.4	-0.5	0.5
Hearing difficulty/problems: Yes	2.1	3.2	7.6	1.4	-0.3	2.7
Relative age of first facial hair	1.0	2.2	2.5	-1.5	1.3	-1.6
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.7	-1.4	-0.8	-1.6
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.2	-0.3	-0.5	-0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.3	-0.3	-0.7
Systolic blood pressure, automated reading	0.3	0.7	1.3	1.0	1.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.8	-0.0	-1.7	0.2
Angina	0.5	0.7	2.0	0.0	0.1	-1.4
Medication for hormone replacement therapy	1.3	1.5	4.0	-2.0	-0.6	-0.1
Vitamin and mineral supplements	0.2	0.3	0.9	-0.1	0.9	0.2
Supplements: Zinc	0.3	0.3	0.6	-0.5	0.2	0.8
Medication: Co-codamol	1.1	1.3	2.7	1.6	-0.4	1.0
Medication: Metformin	1.5	2.2	5.9	0.3	-2.4	0.7
Diabetes (father)	1.9	2.4	4.5	-1.3	1.0	-2.1
Diabetes (mother)	1.6	2.1	5.5	0.9	-2.3	0.2
Severe depression (siblings)	0.1	0.1	0.2	-0.4	-0.3	0.1
Pack years adult smoking proportion	0.2	0.3	0.5	-0.6	-0.7	0.2
Impedance of leg (right)	0.0	0.0	0.1	-0.2	-0.1	-0.2
Leg fat-free mass (left)	0.0	0.1	0.1	0.4	-0.2	0.0
Trunk fat percentage	0.3	1.1	1.7	1.1	-0.4	1.3
Hand grip strength (right)	0.5	1.4	2.7	0.4	-1.2	1.6
Townsend deprivation index at recruitment	0.1	0.2	0.5	0.2	0.7	-0.2
Current tobacco smoking	0.1	0.2	0.7	0.8	-0.0	0.0
Average weekly fortified wine intake	1.0	1.2	1.6	0.5	-1.3	1.3
Maternal smoking around birth	0.6	0.9	2.6	-1.6	-0.1	-0.3
Fed-up feelings	0.5	1.0	2.0	-0.9	-0.4	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.2	-1.1	1.8	-1.0
Relative age voice broke	0.8	1.2	2.5	-0.9	1.6	-0.5
Taking other prescription medications	0.3	0.4	0.8	-0.3	-0.5	0.9
Age when periods started (menarche)	1.7	4.0	10.5	1.1	3.2	-0.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.1	-0.7	-0.6	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.3	-0.0	-0.5	0.1
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.2	1.0	1.0	1.8
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.7	-0.6	0.2
Serious illness, injury or assault to yourself	1.9	2.3	5.8	-2.4	-0.4	-0.9
High blood pressure	0.5	1.5	3.3	1.0	-1.8	0.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.4	-1.2	-1.6	-0.9
Multivitamins +/- minerals	1.2	1.6	2.2	-1.5	-1.3	-0.9
Stomach or abdominal pain in last month	0.6	0.7	1.3	-0.9	1.1	0.3
Supplements: Glucosamine	0.4	0.5	1.2	-1.1	-0.1	0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	-1.3	-0.3	0.6
Medication: Atenolol	0.4	0.5	1.3	0.3	1.1	-0.4
Medication: Levothyroxine sodium	1.1	1.9	2.7	-1.6	-0.6	-1.6
Sitting height	0.1	1.0	2.1	-0.1	-1.4	-0.9
Chronic bronchitis/emphysema (father)	0.6	0.8	1.6	-1.3	-0.7	-0.4
High blood pressure (mother)	2.7	3.8	6.7	0.3	-2.6	2.2
Body mass index (BMI)	0.4	1.6	2.3	1.4	-0.7	1.5
Impedance of leg (left)	0.0	0.1	0.2	-0.3	0.4	-0.2
Leg predicted mass (left)	0.0	0.1	0.1	0.4	-0.4	0.0
Trunk fat mass	0.3	1.1	2.1	1.0	-0.5	1.5
Waist circumference	0.1	0.4	0.7	0.8	-0.5	0.6
Number of incorrect matches in round	0.2	0.3	0.6	-0.1	0.8	-0.4
Past tobacco smoking	0.7	1.2	1.7	0.9	1.3	1.1
Alcohol usually taken with meals	0.9	1.4	2.7	-0.8	1.0	-1.6
Nervous feelings	0.5	1.0	1.5	-1.2	0.7	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.7	0.5	1.6	0.0
Hearing difficulty/problems with background noise	1.5	2.4	3.5	-0.7	-1.9	1.8
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.7	-0.1	-0.3
Had menopause	3.6	4.5	8.3	0.7	2.9	-2.1
Had other major operations	0.1	0.1	0.3	0.5	0.0	-0.1
Forced vital capacity (FVC)	0.2	0.6	1.3	-1.1	0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.1	-0.9	-0.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.7	0.7	1.6	0.2
Qualifications: None of the above	0.6	1.2	3.2	-1.8	0.1	-0.6
Financial difficulties in last 2 years	0.3	0.4	0.9	0.3	-1.0	-0.4
Mouth/teeth dental problems	1.4	2.1	3.5	1.9	-0.2	1.7
Heart attack	1.7	2.1	5.2	-0.3	-1.1	-2.3
Allergy	0.8	1.8	3.7	1.1	1.9	0.6
Pain all over the body in last month	2.2	2.3	3.0	1.3	1.7	1.5
Diabetes (self-reported)	0.9	1.4	3.3	-0.1	-1.8	-0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.8	0.1	-0.6	-1.4
Medication: Ramipril	0.4	0.6	1.7	1.3	-0.0	-0.1
Medication: Simvastatin	0.3	0.4	0.6	-0.7	-0.3	-0.8
Fluid intelligence score	0.2	0.4	0.7	0.5	0.8	-0.5
Illnesses of siblings	0.1	0.2	0.5	0.7	-0.1	-0.1
Neuroticism score	0.3	0.5	1.6	-1.3	-0.0	-0.1
Weight	0.2	0.9	1.5	1.2	-0.6	0.9
Impedance of arm (right)	0.1	0.4	0.7	-0.4	0.6	-0.8
Arm fat percentage (right)	0.4	1.6	2.6	1.4	-0.6	1.6
Trunk fat-free mass	0.0	0.2	0.4	0.2	-0.4	-0.6
Hip circumference	0.2	0.8	2.3	1.5	-0.3	0.2
Time employed in main current job	1.2	1.4	3.2	-0.0	-0.9	1.8
Alcohol intake versus 10 years previously	2.1	3.2	9.0	0.5	-3.0	0.5
Father’s age at death	0.1	0.2	0.5	0.1	-0.0	0.7
Worrier / anxious feelings	0.6	1.2	3.1	-0.2	1.8	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.1	-0.9	-0.2	1.1
Falls in the last year	0.2	0.2	0.6	0.8	0.1	-0.1
Hair/balding pattern: Pattern 3	1.4	2.0	4.5	0.5	-1.2	2.1
Number of live births	0.2	0.3	0.7	-0.3	0.9	0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	-0.3	-0.2	-0.1
Pulse rate	0.3	0.6	1.1	-1.0	-0.8	-0.1
Happiness	0.8	1.0	1.3	0.7	1.1	1.1
Noisy workplace	1.1	1.4	2.2	-1.5	-0.4	1.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	0.9	-0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	2.6	-1.2	1.4	-1.6
Mouth/teeth dental problems: Dentures	0.7	1.3	3.0	-0.8	1.7	-0.4
Asthma	0.1	0.1	0.2	0.3	-0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.6	0.6	0.7	1.3
Medication: Cholesterol lowering	1.0	1.6	3.2	-0.5	-1.2	-1.8
Depression (self-reported)	1.5	1.7	3.6	0.2	1.9	1.3
Medication: Lansoprazole	0.6	0.6	1.0	-0.5	1.0	0.8
Prospective memory result	0.0	0.1	0.1	-0.2	-0.2	0.2
Lung cancer (father)	0.1	0.1	0.2	0.3	0.3	-0.5
Illnesses of mother	0.3	0.4	0.9	1.0	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	-0.6	-0.1	-0.5
Pulse wave Arterial Stiffness index	1.0	1.2	3.1	0.8	0.0	-1.8
Impedance of arm (left)	0.1	0.3	0.4	-0.6	0.5	-0.7
Arm fat mass (right)	0.4	1.5	2.3	1.3	-0.5	1.5
Trunk predicted mass	0.0	0.2	0.5	0.2	-0.4	-0.7
Standing height	0.1	0.9	2.4	-0.7	-0.0	-1.5
Length of working week for main job	0.3	0.3	0.4	-0.6	-0.6	0.3
Exposure to tobacco smoke at home	2.1	2.3	3.5	1.1	1.5	1.9
Breastfed as a baby	1.1	1.4	2.9	-1.7	-0.9	-0.7
Tense / ‘highly strung’	0.5	0.8	2.2	-0.0	1.5	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.3	1.5	1.4	0.9
Hair/balding pattern: Pattern 4	0.5	1.2	1.8	1.4	0.8	-1.1
Birth weight of first child	0.7	1.3	2.3	1.0	-1.5	0.8
Peak expiratory flow (PEF)	0.6	1.4	2.0	0.9	-1.2	1.4
Pulse wave reflection index	0.7	0.9	2.5	0.3	0.2	-1.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.5	1.6	1.0	0.1
Loud music exposure frequency	0.2	0.3	0.6	0.0	-0.8	0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.9	0.5	-1.4	-0.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	-1.2	0.3	-0.2
Blood clot in the leg (DVT)	0.3	0.4	1.3	-0.2	-0.1	1.1
Medication: Paracetamol	0.6	1.0	2.7	1.6	0.3	0.4
Headache pain in last month	0.4	0.7	2.0	0.3	-1.4	-0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.6	-0.4	1.6	1.0
Glaucoma (self-reported)	1.3	1.6	2.1	1.4	1.5	0.7
Gout (self-reported)	0.1	0.2	0.3	-0.5	0.4	-0.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.9	-1.4	-0.2	-1.1
Medication: Amlodipine	0.3	0.5	1.2	0.4	0.1	1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	-0.4	-0.7	1.1
Birth weight	0.2	0.5	1.5	-1.2	0.1	0.2
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	-0.9	0.6	-0.4
High blood pressure (siblings)	0.1	0.2	0.6	0.0	-0.8	-0.0
Forced vital capacity (FVC), Best measure	0.3	1.0	2.7	-1.6	0.3	-0.5
Body fat percentage	0.4	1.4	2.5	1.3	-0.2	1.6
Leg fat percentage (right)	0.5	1.8	3.2	1.5	-0.1	1.8
Arm fat-free mass (right)	0.0	0.2	0.3	0.5	-0.4	0.2
Exposure to tobacco smoke outside home	1.1	1.5	2.9	0.4	-1.1	1.7
Comparative body size at age 10	0.4	1.1	1.3	1.1	-1.0	1.0
Number of full brothers	0.5	0.6	0.8	-0.9	0.5	-0.8
Worry too long after embarrassment	0.3	0.5	1.1	-0.4	-1.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.6	0.2	0.8	-1.3
Wheeze or whistling in the chest in last year	1.1	2.0	3.4	-0.4	-1.9	1.5
Number of children fathered	0.6	0.7	1.7	-0.2	1.3	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	4.2	1.1	-0.2	2.0
Age at first live birth	0.1	0.1	0.2	-0.4	-0.4	-0.3
Pulse wave peak to peak time	0.9	1.1	2.6	-0.9	0.0	1.6
Health satisfaction	1.5	1.9	3.4	0.6	1.4	1.8
Shortness of breath walking on level ground	1.9	2.3	5.5	1.2	2.4	0.1
Qualifications: College or University degree	0.3	1.0	2.6	1.6	0.5	-0.5
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.7	-0.1	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	0.4	0.8	-0.3
Emphysema/chronic bronchitis	0.9	1.0	1.8	-0.6	1.3	0.9
Medication for pain relief, constipation, heartburn	0.4	0.6	1.7	-1.3	-0.4	-0.2
Neck or shoulder pain in last month	0.3	0.5	1.0	0.7	-0.0	1.0
Medication: Blood pressure	0.9	1.6	3.9	0.8	-2.0	-0.5
Angina (self-reported)	0.7	1.0	2.6	-0.4	0.3	-1.6
Migraine (self-reported)	1.0	1.2	2.1	1.4	1.0	0.7
Medication: Ibuprofen	0.8	1.0	1.7	0.4	1.0	1.3
Medication: Allopurinol	0.2	0.3	0.7	-0.2	0.8	-0.4
Medication: Omeprazole	0.7	0.9	2.6	-0.1	1.6	0.3
Medication: Seretide 50 evohaler	0.9	1.1	1.6	-1.2	0.3	1.3
Mean time to correctly identify matches	0.2	0.3	1.0	-0.1	1.0	0.1
Heart disease (mother)	0.7	0.8	2.3	0.3	1.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.1	1.0	-0.1	0.5
Whole body fat mass	0.3	1.4	2.5	1.2	-0.4	1.6
Leg fat mass (right)	0.4	1.5	3.1	1.2	-0.2	1.8
Arm predicted mass (right)	0.0	0.1	0.2	0.4	-0.3	0.0
Pulse rate, automated reading	0.5	1.5	3.7	-1.9	-0.6	-0.7
Alcohol intake frequency.	1.1	2.6	6.9	0.5	-2.6	-0.7
Comparative height size at age 10	0.0	0.3	0.4	-0.1	-0.6	-0.7
Number of full sisters	1.7	2.0	5.1	-2.3	-0.9	0.4
Suffer from ‘nerves’	0.3	0.4	0.7	0.3	0.6	0.8
Overall health rating	0.3	0.5	1.6	-1.3	-0.1	-0.0
Chest pain or discomfort	0.8	1.1	1.9	0.3	1.1	-1.4
Had major operations	2.4	2.8	6.2	2.5	1.5	0.0
Age at last live birth	0.5	0.8	2.3	-0.1	-0.2	1.5
Family relationship satisfaction	1.8	2.2	3.2	1.8	1.8	0.3
Leg pain on walking	0.4	0.5	0.8	0.9	0.8	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.3	-0.6	-1.5	0.5
Commuting to job workplace: Car/motor vehicle	2.5	2.9	4.5	-0.4	-2.1	2.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.1	1.8	-1.0	0.9
Medication: Aspirin	0.2	0.2	0.4	0.4	-0.7	-0.1
Supplements: Vitamin C	2.4	2.9	5.9	2.4	0.3	1.6
Knee pain experienced in last month	1.1	1.7	4.1	1.0	0.0	2.0
Hypertension (Self-reported)	0.5	1.4	3.0	1.0	-1.7	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.5	0.2	0.1
Illnesses of father: Heart disease	0.4	0.5	1.0	1.0	-0.4	-0.6
Illnesses of siblings: Diabetes	0.1	0.2	0.5	0.2	0.0	-0.7
Smoking status: Previous	0.9	1.3	2.8	-1.0	-1.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	1.5	-0.6	-1.2	-1.0
Whole body fat-free mass	0.0	0.1	0.2	0.2	-0.3	-0.5
Leg fat-free mass (right)	0.0	0.0	0.0	0.2	-0.0	-0.1
Arm fat percentage (left)	0.4	1.8	3.2	1.3	-0.6	1.8
Average weekly red wine intake	1.6	2.4	4.3	-1.0	1.4	-2.1
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	-0.2	0.2	0.0
Mood swings	0.4	0.7	1.0	-1.0	-0.6	0.8
Loneliness, isolation	0.1	0.1	0.3	0.1	-0.6	-0.3
Long-standing illness, disability or infirmity	0.4	0.6	1.4	0.0	-0.6	-1.2
Ever had bowel cancer screening	0.7	0.8	1.3	-0.3	1.0	-1.2
Diabetes diagnosed by doctor	1.1	1.8	4.3	-0.3	-2.1	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.7	-0.4	0.4
Friendships satisfaction	1.4	1.8	2.8	1.7	1.5	0.4
Qualifications: nursing, teaching	0.3	0.5	0.9	0.7	-0.9	-0.4
Commuting to job workplace: Walk	0.5	0.5	1.0	0.8	1.0	0.2
Eye problems/disorders: Cataract	1.1	1.3	3.5	0.0	0.5	-1.9
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.5	-1.2	-1.1	-0.4
Medication for cholesterol	0.1	0.1	0.2	0.0	-0.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	0.1	0.2
Back pain experienced in last month	0.5	0.7	2.0	-1.4	-0.2	-0.1
Mineral and other dietary supplements	0.2	0.2	0.4	0.4	0.4	-0.6
Breast cancer (self-reported)	0.6	0.7	1.1	-0.0	1.1	1.0
Asthma (self-reported)	0.0	0.0	0.0	0.0	-0.0	0.1
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.7	-0.1	0.4
Osteoarthritis (self-reported)	3.0	3.9	4.0	1.9	2.0	2.0
Medication: Aspirin	0.2	0.3	0.5	0.7	-0.4	0.5
Medication: Gliclazide	0.3	0.4	1.1	0.1	1.1	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	0.6	0.7	0.8	0.6
Smoking status: Current	0.2	0.4	0.9	0.9	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	-0.9	0.1	-1.5
Whole body water mass	0.0	0.1	0.2	0.3	-0.4	-0.3
Leg predicted mass (right)	0.0	0.0	0.1	0.2	-0.0	-0.1
Arm fat mass (left)	0.4	1.5	2.2	1.4	-0.5	1.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	-0.2	-0.7	-0.1
Average weekly champagne plus white wine intake	0.9	1.2	1.7	-0.4	1.3	-1.3
Miserableness	0.1	0.1	0.1	-0.3	-0.4	0.3
Guilty feelings	0.4	0.7	0.9	0.7	1.0	0.7
Wears glasses or contact lenses	0.3	0.3	0.7	0.5	-0.3	0.8
Ever taken oral contraceptive pill	0.6	0.6	1.1	-0.7	-1.1	-0.5
Hearing aid user	0.8	0.9	1.4	-0.8	-0.8	-1.2
Mother’s age at death	4.3	5.4	8.2	2.2	2.9	1.7
Financial situation satisfaction	0.5	0.7	1.5	0.5	0.5	1.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.2	-0.3	0.5
Commuting to job workplace: Public transport	0.6	0.7	1.3	0.6	0.6	-1.1
Eye problems/disorders: Glaucoma	1.1	1.3	2.3	1.5	0.4	1.2
Medication: Blood pressure	0.5	0.9	2.0	1.4	0.8	-0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	0.5	1.1	0.3
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	-0.0	-0.1	-0.3
High cholesterol (Self-reported)	0.3	0.4	0.9	-0.7	-0.9	0.0
Medication: Bendroflumethiazide	1.2	1.9	5.3	2.3	0.4	0.3
Medication: Paracetamol	0.3	0.4	0.8	0.9	0.7	-0.2
Medication: Lisinopril	2.3	3.0	8.4	0.6	-2.9	-0.4
Medication: Atorvastatin	1.1	1.4	2.5	-0.0	-1.6	-1.2
Illnesses of father: High blood pressure	1.7	2.1	5.5	0.6	-0.7	2.4
Alcohol drinker status: Never	1.3	1.6	2.8	1.7	0.9	1.0
Ever smoked	0.7	1.3	2.6	-0.8	-0.8	-1.6
Basal metabolic rate	0.0	0.2	0.4	0.6	-0.4	-0.0
Leg fat percentage (left)	0.5	1.8	3.0	1.5	0.3	1.7
Arm fat-free mass (left)	0.0	0.2	0.6	0.7	-0.3	0.0
Number of operations (self-reported)	0.3	0.4	0.9	1.0	-0.4	0.4
Average weekly beer plus cider intake	0.8	1.2	2.3	0.7	-0.9	1.5
Irritability	0.1	0.1	0.3	-0.6	0.2	0.1
Risk taking	0.3	0.4	1.3	-1.1	-0.1	0.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.2	0.2	-1.1	-0.0
Fractured/broken bones in last 5 years	0.6	0.7	1.8	-0.5	1.4	-0.3
Age started oral contraceptive pill	0.7	0.9	2.4	-0.1	0.5	-1.6
Diastolic blood pressure, automated reading	0.2	0.8	1.8	0.6	0.5	1.3
Ever depressed for a whole week	0.3	0.4	1.0	0.3	0.4	-1.0
Unable to work because of sickness or disability	0.5	0.6	1.4	1.2	0.5	0.4
Commuting to job workplace: Cycle	0.4	0.4	1.3	-0.2	0.1	-1.1
Myopia	0.3	0.4	1.2	-1.1	0.0	0.1
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.5	-1.0	1.9	0.4
Cholesterol lowering medication	0.1	0.1	0.4	0.2	0.0	0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.5	0.0	1.6	0.4
Pain experienced in last month	0.2	0.4	1.1	-0.3	0.0	-1.1
Supplements: Calcium	0.3	0.4	1.0	0.0	-0.3	1.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.1	-0.3	-0.7
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.0	-0.3	-1.1	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.2	-0.3	-0.5	1.1
Heart disease (siblings)	0.4	0.5	1.4	0.1	1.2	-0.1
Alcohol drinker status: Previous	1.2	1.3	2.2	-1.3	-0.4	-1.5
Pack years of smoking	0.2	0.2	0.4	-0.6	-0.6	-0.0
Impedance of whole body	0.0	0.2	0.2	-0.4	0.5	-0.4
Leg fat mass (left)	0.3	1.3	2.5	1.2	0.0	1.6
Arm predicted mass (left)	0.0	0.1	0.3	0.5	-0.3	-0.2