Hub : Genes

XKR8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.1129 0.0309 4.2e-12 0.096 0.094 0.105 0.093 0.108 3.2e-14 6.1e-14 2.2e-15 8.3e-14 6.9e-16
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0369 0.0189 3.5e-03 0.006 0.010 0.021 NA 0.016 6.8e-02 2.2e-02 1.7e-03 NA 6.3e-03
3 TCGA Thyroid Carcinoma 0.0800 0.0360 1.2e-04 0.024 0.043 0.038 NA 0.039 1.9e-03 4.3e-05 1.3e-04 NA 1.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.2 0.3 0.6 0.5 0.3
Bipolar Disorder or Schizophrenia 0.5 1.3 2.8 -1.7 0.6 -0.9
Depressed Affect (Nagel 2018) 0.6 1.3 2.9 -1.7 -1.0 -0.4
Depression (Nagel 2018) 0.5 0.7 1.6 -1.3 0.8 -0.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 2.1 1.4 0.6 -0.3
Neuroticism (Nagel 2018) 0.3 0.7 2.0 -1.4 -0.0 -0.1
Schizophrenia (2018) 1.4 2.8 6.6 -2.6 0.3 -1.4
Schizophrenia vs Biploar Disorder 0.5 0.6 1.7 -1.3 -0.3 0.0
Worry (Nagel 2018) 0.3 0.6 1.0 -0.8 1.0 -0.3
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 -0.7 0.1 0.4
Alzheimer’s Disease (in father) 2.1 2.3 4.3 2.1 1.5 -0.4
Alzheimer’s Disease (including proxy) 0.2 0.3 0.6 0.8 0.3 -0.4
Crohns Disease (2017) 1.7 3.6 8.8 3.0 1.4 -0.5
Irritable Bowel Disease (IBD) 1.8 4.2 8.7 3.0 2.0 -0.3
Ulcerative Colitis (UC) 1.0 1.9 3.2 1.8 1.6 0.1
Major Depression (MDD) 0.6 0.7 1.6 -1.3 0.4 -0.5
Reaction Time 0.2 0.4 0.8 -0.4 0.5 0.9
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.5 1.6 -0.5 0.4
Breast Cancer 0.2 0.4 0.8 -0.5 0.4 -0.9
Ovarian Cancer 0.2 0.3 0.5 0.2 0.6 -0.7
Prostate Cancer 0.6 0.8 1.2 1.1 1.1 0.1
Age at First Birth 0.5 0.7 1.2 -1.1 0.9 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.3 3.7 1.9 0.2 0.0
Coronary Artery Disease (CAD) 0.7 0.8 1.4 0.7 0.7 -1.2
Crohns Disease (2012) 0.9 1.4 3.4 0.7 0.6 -1.8
Mean Putamen Volume 0.3 0.4 1.0 0.2 1.0 0.3
Fasting Glucose 0.4 0.5 0.8 -0.8 -0.3 -0.9
HbA1C 1.7 1.9 3.3 0.5 -1.8 1.4
HDL Cholesterol 0.2 0.3 0.7 -0.8 0.1 -0.4
LDL Cholesterol 1.2 1.9 3.4 -1.4 0.6 -1.9
Lupus 0.5 0.7 1.3 -0.5 -1.2 0.8
Neuroticism (2016) 0.5 0.7 1.7 -0.4 1.3 -0.2
Primary Biliary Cirrhosis 0.1 0.1 0.2 -0.0 0.3 -0.4
Rheumatoid Arthritis 1.3 1.8 3.8 -0.3 1.3 -1.9
Schizophrenia (2014) 1.0 2.3 5.8 -2.4 0.5 -1.0
Triglycerides 0.1 0.2 0.6 -0.8 0.1 0.2
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.5 -0.3 -0.3 -1.2
Ulcerative Colitis 1.1 1.7 2.6 1.4 1.6 -0.7
Blood Eosinophil Count 0.5 3.8 11.1 3.3 -0.4 -0.3
Blood Platelet Count 1.6 18.7 52.3 7.2 -1.7 1.0
Blood Red Count 0.9 8.6 16.6 4.1 -0.1 3.0
Blood White Count 0.7 5.0 13.5 3.7 -0.9 0.8
Heel T-Score 0.5 3.6 5.4 1.3 -2.3 1.9
BMI 0.5 2.8 5.7 1.6 -0.4 2.4
Height 0.1 2.1 5.2 -0.7 0.7 -2.3
Waist Hip Ratio (WHR) 0.0 0.2 0.5 -0.7 0.0 -0.2
Systolic Blood Pressure 0.2 0.9 1.8 1.4 -1.0 0.2
Smoking Status 0.4 0.9 2.4 -0.5 -1.6 -0.2
Allergy or Eczema 0.2 0.5 0.9 0.0 -0.7 -1.0
Cardiovascular Disease 0.4 1.2 2.5 1.6 -1.0 0.3
Hypothyroidism (self reported) 0.3 0.7 1.4 -1.2 -0.7 -0.4
Respiratory disease 0.1 0.2 0.4 -0.7 0.2 -0.1
Type 2 Diabetes (T2D) (2018) 1.3 2.4 6.2 -0.8 -2.5 -0.6
Lung FEV1/FVC ratio 0.5 2.8 5.2 1.7 -2.3 0.2
Lung FVC 0.5 2.5 4.6 -2.1 0.5 -1.6
Neuroticism 0.6 1.5 3.6 -1.9 -0.7 -0.6
Chronotype (morning person) 1.5 3.4 4.9 -0.9 2.1 -2.2
Hair Pigment 0.0 1.0 2.7 0.5 -0.0 -1.6
Tanning 0.1 1.1 1.9 1.4 0.6 1.0
Hand grip strength (left) 0.3 0.8 1.0 1.0 -0.7 0.9
Number of treatments/medications taken 0.1 0.1 0.2 0.5 -0.4 -0.1
Average weekly spirits intake 0.4 0.6 1.7 -1.3 -0.0 0.1
Sensitivity / hurt feelings 0.1 0.2 0.7 -0.8 0.2 0.1
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.2 -0.4 -0.5 0.5
Hearing difficulty/problems: Yes 2.1 3.2 7.6 1.4 -0.3 2.7
Relative age of first facial hair 1.0 2.2 2.5 -1.5 1.3 -1.6
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 2.7 -1.4 -0.8 -1.6
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.2 -0.3 -0.5 -0.4
Ever had hysterectomy (womb removed) 0.2 0.2 0.4 -0.3 -0.3 -0.7
Systolic blood pressure, automated reading 0.3 0.7 1.3 1.0 1.1 0.1
Eye problems/disorders: Diabetes related eye disease 0.9 0.9 2.8 -0.0 -1.7 0.2
Angina 0.5 0.7 2.0 0.0 0.1 -1.4
Medication for hormone replacement therapy 1.3 1.5 4.0 -2.0 -0.6 -0.1
Vitamin and mineral supplements 0.2 0.3 0.9 -0.1 0.9 0.2
Supplements: Zinc 0.3 0.3 0.6 -0.5 0.2 0.8
Medication: Co-codamol 1.1 1.3 2.7 1.6 -0.4 1.0
Medication: Metformin 1.5 2.2 5.9 0.3 -2.4 0.7
Diabetes (father) 1.9 2.4 4.5 -1.3 1.0 -2.1
Diabetes (mother) 1.6 2.1 5.5 0.9 -2.3 0.2
Severe depression (siblings) 0.1 0.1 0.2 -0.4 -0.3 0.1
Pack years adult smoking proportion 0.2 0.3 0.5 -0.6 -0.7 0.2
Impedance of leg (right) 0.0 0.0 0.1 -0.2 -0.1 -0.2
Leg fat-free mass (left) 0.0 0.1 0.1 0.4 -0.2 0.0
Trunk fat percentage 0.3 1.1 1.7 1.1 -0.4 1.3
Hand grip strength (right) 0.5 1.4 2.7 0.4 -1.2 1.6
Townsend deprivation index at recruitment 0.1 0.2 0.5 0.2 0.7 -0.2
Current tobacco smoking 0.1 0.2 0.7 0.8 -0.0 0.0
Average weekly fortified wine intake 1.0 1.2 1.6 0.5 -1.3 1.3
Maternal smoking around birth 0.6 0.9 2.6 -1.6 -0.1 -0.3
Fed-up feelings 0.5 1.0 2.0 -0.9 -0.4 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 3.2 -1.1 1.8 -1.0
Relative age voice broke 0.8 1.2 2.5 -0.9 1.6 -0.5
Taking other prescription medications 0.3 0.4 0.8 -0.3 -0.5 0.9
Age when periods started (menarche) 1.7 4.0 10.5 1.1 3.2 -0.6
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 3.1 -0.7 -0.6 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.3 -0.0 -0.5 0.1
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 3.2 1.0 1.0 1.8
Qualifications: CSEs or equivalent 0.2 0.3 0.5 0.7 -0.6 0.2
Serious illness, injury or assault to yourself 1.9 2.3 5.8 -2.4 -0.4 -0.9
High blood pressure 0.5 1.5 3.3 1.0 -1.8 0.1
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.4 -1.2 -1.6 -0.9
Multivitamins +/- minerals 1.2 1.6 2.2 -1.5 -1.3 -0.9
Stomach or abdominal pain in last month 0.6 0.7 1.3 -0.9 1.1 0.3
Supplements: Glucosamine 0.4 0.5 1.2 -1.1 -0.1 0.6
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.7 -1.3 -0.3 0.6
Medication: Atenolol 0.4 0.5 1.3 0.3 1.1 -0.4
Medication: Levothyroxine sodium 1.1 1.9 2.7 -1.6 -0.6 -1.6
Sitting height 0.1 1.0 2.1 -0.1 -1.4 -0.9
Chronic bronchitis/emphysema (father) 0.6 0.8 1.6 -1.3 -0.7 -0.4
High blood pressure (mother) 2.7 3.8 6.7 0.3 -2.6 2.2
Body mass index (BMI) 0.4 1.6 2.3 1.4 -0.7 1.5
Impedance of leg (left) 0.0 0.1 0.2 -0.3 0.4 -0.2
Leg predicted mass (left) 0.0 0.1 0.1 0.4 -0.4 0.0
Trunk fat mass 0.3 1.1 2.1 1.0 -0.5 1.5
Waist circumference 0.1 0.4 0.7 0.8 -0.5 0.6
Number of incorrect matches in round 0.2 0.3 0.6 -0.1 0.8 -0.4
Past tobacco smoking 0.7 1.2 1.7 0.9 1.3 1.1
Alcohol usually taken with meals 0.9 1.4 2.7 -0.8 1.0 -1.6
Nervous feelings 0.5 1.0 1.5 -1.2 0.7 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.7 0.5 1.6 0.0
Hearing difficulty/problems with background noise 1.5 2.4 3.5 -0.7 -1.9 1.8
Hair/balding pattern: Pattern 2 0.2 0.2 0.5 -0.7 -0.1 -0.3
Had menopause 3.6 4.5 8.3 0.7 2.9 -2.1
Had other major operations 0.1 0.1 0.3 0.5 0.0 -0.1
Forced vital capacity (FVC) 0.2 0.6 1.3 -1.1 0.2 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.8 0.1 -0.9 -0.1
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.7 0.7 1.6 0.2
Qualifications: None of the above 0.6 1.2 3.2 -1.8 0.1 -0.6
Financial difficulties in last 2 years 0.3 0.4 0.9 0.3 -1.0 -0.4
Mouth/teeth dental problems 1.4 2.1 3.5 1.9 -0.2 1.7
Heart attack 1.7 2.1 5.2 -0.3 -1.1 -2.3
Allergy 0.8 1.8 3.7 1.1 1.9 0.6
Pain all over the body in last month 2.2 2.3 3.0 1.3 1.7 1.5
Diabetes (self-reported) 0.9 1.4 3.3 -0.1 -1.8 -0.9
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 1.8 0.1 -0.6 -1.4
Medication: Ramipril 0.4 0.6 1.7 1.3 -0.0 -0.1
Medication: Simvastatin 0.3 0.4 0.6 -0.7 -0.3 -0.8
Fluid intelligence score 0.2 0.4 0.7 0.5 0.8 -0.5
Illnesses of siblings 0.1 0.2 0.5 0.7 -0.1 -0.1
Neuroticism score 0.3 0.5 1.6 -1.3 -0.0 -0.1
Weight 0.2 0.9 1.5 1.2 -0.6 0.9
Impedance of arm (right) 0.1 0.4 0.7 -0.4 0.6 -0.8
Arm fat percentage (right) 0.4 1.6 2.6 1.4 -0.6 1.6
Trunk fat-free mass 0.0 0.2 0.4 0.2 -0.4 -0.6
Hip circumference 0.2 0.8 2.3 1.5 -0.3 0.2
Time employed in main current job 1.2 1.4 3.2 -0.0 -0.9 1.8
Alcohol intake versus 10 years previously 2.1 3.2 9.0 0.5 -3.0 0.5
Father’s age at death 0.1 0.2 0.5 0.1 -0.0 0.7
Worrier / anxious feelings 0.6 1.2 3.1 -0.2 1.8 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.1 -0.9 -0.2 1.1
Falls in the last year 0.2 0.2 0.6 0.8 0.1 -0.1
Hair/balding pattern: Pattern 3 1.4 2.0 4.5 0.5 -1.2 2.1
Number of live births 0.2 0.3 0.7 -0.3 0.9 0.4
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.1 -0.3 -0.2 -0.1
Pulse rate 0.3 0.6 1.1 -1.0 -0.8 -0.1
Happiness 0.8 1.0 1.3 0.7 1.1 1.1
Noisy workplace 1.1 1.4 2.2 -1.5 -0.4 1.3
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.8 0.9 -0.1 -0.3
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.0 2.6 -1.2 1.4 -1.6
Mouth/teeth dental problems: Dentures 0.7 1.3 3.0 -0.8 1.7 -0.4
Asthma 0.1 0.1 0.2 0.3 -0.5 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.6 0.6 0.7 1.3
Medication: Cholesterol lowering 1.0 1.6 3.2 -0.5 -1.2 -1.8
Depression (self-reported) 1.5 1.7 3.6 0.2 1.9 1.3
Medication: Lansoprazole 0.6 0.6 1.0 -0.5 1.0 0.8
Prospective memory result 0.0 0.1 0.1 -0.2 -0.2 0.2
Lung cancer (father) 0.1 0.1 0.2 0.3 0.3 -0.5
Illnesses of mother 0.3 0.4 0.9 1.0 0.3 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.4 -0.6 -0.1 -0.5
Pulse wave Arterial Stiffness index 1.0 1.2 3.1 0.8 0.0 -1.8
Impedance of arm (left) 0.1 0.3 0.4 -0.6 0.5 -0.7
Arm fat mass (right) 0.4 1.5 2.3 1.3 -0.5 1.5
Trunk predicted mass 0.0 0.2 0.5 0.2 -0.4 -0.7
Standing height 0.1 0.9 2.4 -0.7 -0.0 -1.5
Length of working week for main job 0.3 0.3 0.4 -0.6 -0.6 0.3
Exposure to tobacco smoke at home 2.1 2.3 3.5 1.1 1.5 1.9
Breastfed as a baby 1.1 1.4 2.9 -1.7 -0.9 -0.7
Tense / ‘highly strung’ 0.5 0.8 2.2 -0.0 1.5 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 2.3 1.5 1.4 0.9
Hair/balding pattern: Pattern 4 0.5 1.2 1.8 1.4 0.8 -1.1
Birth weight of first child 0.7 1.3 2.3 1.0 -1.5 0.8
Peak expiratory flow (PEF) 0.6 1.4 2.0 0.9 -1.2 1.4
Pulse wave reflection index 0.7 0.9 2.5 0.3 0.2 -1.6
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.5 1.6 1.0 0.1
Loud music exposure frequency 0.2 0.3 0.6 0.0 -0.8 0.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 1.9 0.5 -1.4 -0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 -1.2 0.3 -0.2
Blood clot in the leg (DVT) 0.3 0.4 1.3 -0.2 -0.1 1.1
Medication: Paracetamol 0.6 1.0 2.7 1.6 0.3 0.4
Headache pain in last month 0.4 0.7 2.0 0.3 -1.4 -0.0
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 2.6 -0.4 1.6 1.0
Glaucoma (self-reported) 1.3 1.6 2.1 1.4 1.5 0.7
Gout (self-reported) 0.1 0.2 0.3 -0.5 0.4 -0.0
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 1.9 -1.4 -0.2 -1.1
Medication: Amlodipine 0.3 0.5 1.2 0.4 0.1 1.1
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.1 -0.4 -0.7 1.1
Birth weight 0.2 0.5 1.5 -1.2 0.1 0.2
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.8 -0.9 0.6 -0.4
High blood pressure (siblings) 0.1 0.2 0.6 0.0 -0.8 -0.0
Forced vital capacity (FVC), Best measure 0.3 1.0 2.7 -1.6 0.3 -0.5
Body fat percentage 0.4 1.4 2.5 1.3 -0.2 1.6
Leg fat percentage (right) 0.5 1.8 3.2 1.5 -0.1 1.8
Arm fat-free mass (right) 0.0 0.2 0.3 0.5 -0.4 0.2
Exposure to tobacco smoke outside home 1.1 1.5 2.9 0.4 -1.1 1.7
Comparative body size at age 10 0.4 1.1 1.3 1.1 -1.0 1.0
Number of full brothers 0.5 0.6 0.8 -0.9 0.5 -0.8
Worry too long after embarrassment 0.3 0.5 1.1 -0.4 -1.1 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 1.6 0.2 0.8 -1.3
Wheeze or whistling in the chest in last year 1.1 2.0 3.4 -0.4 -1.9 1.5
Number of children fathered 0.6 0.7 1.7 -0.2 1.3 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 4.2 1.1 -0.2 2.0
Age at first live birth 0.1 0.1 0.2 -0.4 -0.4 -0.3
Pulse wave peak to peak time 0.9 1.1 2.6 -0.9 0.0 1.6
Health satisfaction 1.5 1.9 3.4 0.6 1.4 1.8
Shortness of breath walking on level ground 1.9 2.3 5.5 1.2 2.4 0.1
Qualifications: College or University degree 0.3 1.0 2.6 1.6 0.5 -0.5
Eye problems/disorders: None of the above 0.2 0.2 0.5 -0.7 -0.1 0.3
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.6 0.4 0.8 -0.3
Emphysema/chronic bronchitis 0.9 1.0 1.8 -0.6 1.3 0.9
Medication for pain relief, constipation, heartburn 0.4 0.6 1.7 -1.3 -0.4 -0.2
Neck or shoulder pain in last month 0.3 0.5 1.0 0.7 -0.0 1.0
Medication: Blood pressure 0.9 1.6 3.9 0.8 -2.0 -0.5
Angina (self-reported) 0.7 1.0 2.6 -0.4 0.3 -1.6
Migraine (self-reported) 1.0 1.2 2.1 1.4 1.0 0.7
Medication: Ibuprofen 0.8 1.0 1.7 0.4 1.0 1.3
Medication: Allopurinol 0.2 0.3 0.7 -0.2 0.8 -0.4
Medication: Omeprazole 0.7 0.9 2.6 -0.1 1.6 0.3
Medication: Seretide 50 evohaler 0.9 1.1 1.6 -1.2 0.3 1.3
Mean time to correctly identify matches 0.2 0.3 1.0 -0.1 1.0 0.1
Heart disease (mother) 0.7 0.8 2.3 0.3 1.5 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.1 1.0 -0.1 0.5
Whole body fat mass 0.3 1.4 2.5 1.2 -0.4 1.6
Leg fat mass (right) 0.4 1.5 3.1 1.2 -0.2 1.8
Arm predicted mass (right) 0.0 0.1 0.2 0.4 -0.3 0.0
Pulse rate, automated reading 0.5 1.5 3.7 -1.9 -0.6 -0.7
Alcohol intake frequency. 1.1 2.6 6.9 0.5 -2.6 -0.7
Comparative height size at age 10 0.0 0.3 0.4 -0.1 -0.6 -0.7
Number of full sisters 1.7 2.0 5.1 -2.3 -0.9 0.4
Suffer from ‘nerves’ 0.3 0.4 0.7 0.3 0.6 0.8
Overall health rating 0.3 0.5 1.6 -1.3 -0.1 -0.0
Chest pain or discomfort 0.8 1.1 1.9 0.3 1.1 -1.4
Had major operations 2.4 2.8 6.2 2.5 1.5 0.0
Age at last live birth 0.5 0.8 2.3 -0.1 -0.2 1.5
Family relationship satisfaction 1.8 2.2 3.2 1.8 1.8 0.3
Leg pain on walking 0.4 0.5 0.8 0.9 0.8 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 2.3 -0.6 -1.5 0.5
Commuting to job workplace: Car/motor vehicle 2.5 2.9 4.5 -0.4 -2.1 2.0
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.1 1.8 -1.0 0.9
Medication: Aspirin 0.2 0.2 0.4 0.4 -0.7 -0.1
Supplements: Vitamin C 2.4 2.9 5.9 2.4 0.3 1.6
Knee pain experienced in last month 1.1 1.7 4.1 1.0 0.0 2.0
Hypertension (Self-reported) 0.5 1.4 3.0 1.0 -1.7 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.5 0.2 0.1
Illnesses of father: Heart disease 0.4 0.5 1.0 1.0 -0.4 -0.6
Illnesses of siblings: Diabetes 0.1 0.2 0.5 0.2 0.0 -0.7
Smoking status: Previous 0.9 1.3 2.8 -1.0 -1.7 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 0.9 1.5 -0.6 -1.2 -1.0
Whole body fat-free mass 0.0 0.1 0.2 0.2 -0.3 -0.5
Leg fat-free mass (right) 0.0 0.0 0.0 0.2 -0.0 -0.1
Arm fat percentage (left) 0.4 1.8 3.2 1.3 -0.6 1.8
Average weekly red wine intake 1.6 2.4 4.3 -1.0 1.4 -2.1
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 -0.2 0.2 0.0
Mood swings 0.4 0.7 1.0 -1.0 -0.6 0.8
Loneliness, isolation 0.1 0.1 0.3 0.1 -0.6 -0.3
Long-standing illness, disability or infirmity 0.4 0.6 1.4 0.0 -0.6 -1.2
Ever had bowel cancer screening 0.7 0.8 1.3 -0.3 1.0 -1.2
Diabetes diagnosed by doctor 1.1 1.8 4.3 -0.3 -2.1 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 0.7 -0.4 0.4
Friendships satisfaction 1.4 1.8 2.8 1.7 1.5 0.4
Qualifications: nursing, teaching 0.3 0.5 0.9 0.7 -0.9 -0.4
Commuting to job workplace: Walk 0.5 0.5 1.0 0.8 1.0 0.2
Eye problems/disorders: Cataract 1.1 1.3 3.5 0.0 0.5 -1.9
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.5 -1.2 -1.1 -0.4
Medication for cholesterol 0.1 0.1 0.2 0.0 -0.4 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.4 0.1 0.2
Back pain experienced in last month 0.5 0.7 2.0 -1.4 -0.2 -0.1
Mineral and other dietary supplements 0.2 0.2 0.4 0.4 0.4 -0.6
Breast cancer (self-reported) 0.6 0.7 1.1 -0.0 1.1 1.0
Asthma (self-reported) 0.0 0.0 0.0 0.0 -0.0 0.1
Osteoporosis (self-reported) 0.2 0.2 0.4 -0.7 -0.1 0.4
Osteoarthritis (self-reported) 3.0 3.9 4.0 1.9 2.0 2.0
Medication: Aspirin 0.2 0.3 0.5 0.7 -0.4 0.5
Medication: Gliclazide 0.3 0.4 1.1 0.1 1.1 -0.1
Illnesses of father: None of the above (group 1) 0.4 0.5 0.6 0.7 0.8 0.6
Smoking status: Current 0.2 0.4 0.9 0.9 0.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.2 -0.9 0.1 -1.5
Whole body water mass 0.0 0.1 0.2 0.3 -0.4 -0.3
Leg predicted mass (right) 0.0 0.0 0.1 0.2 -0.0 -0.1
Arm fat mass (left) 0.4 1.5 2.2 1.4 -0.5 1.5
Number of self-reported non-cancer illnesses 0.1 0.2 0.6 -0.2 -0.7 -0.1
Average weekly champagne plus white wine intake 0.9 1.2 1.7 -0.4 1.3 -1.3
Miserableness 0.1 0.1 0.1 -0.3 -0.4 0.3
Guilty feelings 0.4 0.7 0.9 0.7 1.0 0.7
Wears glasses or contact lenses 0.3 0.3 0.7 0.5 -0.3 0.8
Ever taken oral contraceptive pill 0.6 0.6 1.1 -0.7 -1.1 -0.5
Hearing aid user 0.8 0.9 1.4 -0.8 -0.8 -1.2
Mother’s age at death 4.3 5.4 8.2 2.2 2.9 1.7
Financial situation satisfaction 0.5 0.7 1.5 0.5 0.5 1.2
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 -0.2 -0.3 0.5
Commuting to job workplace: Public transport 0.6 0.7 1.3 0.6 0.6 -1.1
Eye problems/disorders: Glaucoma 1.1 1.3 2.3 1.5 0.4 1.2
Medication: Blood pressure 0.5 0.9 2.0 1.4 0.8 -0.1
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.2 0.5 1.1 0.3
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.1 -0.0 -0.1 -0.3
High cholesterol (Self-reported) 0.3 0.4 0.9 -0.7 -0.9 0.0
Medication: Bendroflumethiazide 1.2 1.9 5.3 2.3 0.4 0.3
Medication: Paracetamol 0.3 0.4 0.8 0.9 0.7 -0.2
Medication: Lisinopril 2.3 3.0 8.4 0.6 -2.9 -0.4
Medication: Atorvastatin 1.1 1.4 2.5 -0.0 -1.6 -1.2
Illnesses of father: High blood pressure 1.7 2.1 5.5 0.6 -0.7 2.4
Alcohol drinker status: Never 1.3 1.6 2.8 1.7 0.9 1.0
Ever smoked 0.7 1.3 2.6 -0.8 -0.8 -1.6
Basal metabolic rate 0.0 0.2 0.4 0.6 -0.4 -0.0
Leg fat percentage (left) 0.5 1.8 3.0 1.5 0.3 1.7
Arm fat-free mass (left) 0.0 0.2 0.6 0.7 -0.3 0.0
Number of operations (self-reported) 0.3 0.4 0.9 1.0 -0.4 0.4
Average weekly beer plus cider intake 0.8 1.2 2.3 0.7 -0.9 1.5
Irritability 0.1 0.1 0.3 -0.6 0.2 0.1
Risk taking 0.3 0.4 1.3 -1.1 -0.1 0.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.2 0.2 -1.1 -0.0
Fractured/broken bones in last 5 years 0.6 0.7 1.8 -0.5 1.4 -0.3
Age started oral contraceptive pill 0.7 0.9 2.4 -0.1 0.5 -1.6
Diastolic blood pressure, automated reading 0.2 0.8 1.8 0.6 0.5 1.3
Ever depressed for a whole week 0.3 0.4 1.0 0.3 0.4 -1.0
Unable to work because of sickness or disability 0.5 0.6 1.4 1.2 0.5 0.4
Commuting to job workplace: Cycle 0.4 0.4 1.3 -0.2 0.1 -1.1
Myopia 0.3 0.4 1.2 -1.1 0.0 0.1
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.5 -1.0 1.9 0.4
Cholesterol lowering medication 0.1 0.1 0.4 0.2 0.0 0.6
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.5 0.0 1.6 0.4
Pain experienced in last month 0.2 0.4 1.1 -0.3 0.0 -1.1
Supplements: Calcium 0.3 0.4 1.0 0.0 -0.3 1.0
Basal cell carcinoma (self-reported) 0.2 0.2 0.5 -0.1 -0.3 -0.7
Heart attack/myocardial infarction (self-reported) 1.4 1.8 4.0 -0.3 -1.1 -2.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.2 -0.3 -0.5 1.1
Heart disease (siblings) 0.4 0.5 1.4 0.1 1.2 -0.1
Alcohol drinker status: Previous 1.2 1.3 2.2 -1.3 -0.4 -1.5
Pack years of smoking 0.2 0.2 0.4 -0.6 -0.6 -0.0
Impedance of whole body 0.0 0.2 0.2 -0.4 0.5 -0.4
Leg fat mass (left) 0.3 1.3 2.5 1.2 0.0 1.6
Arm predicted mass (left) 0.0 0.1 0.3 0.5 -0.3 -0.2