TWAS hub - XPO6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.1150	0.0350	3.3e-06	0.075	NA	0.065	NA	0.073	8.0e-07	NA	4.6e-06	NA	1.2e-06
2	GTEx	Thyroid	0.0690	0.0280	1.3e-03	0.059	NA	0.057	NA	0.052	2.5e-05	NA	3.7e-05	NA	7.6e-05
3	METSIM	Adipose	0.0430	0.0163	8.7e-05	0.008	0.026	0.025	0.025	0.013	1.8e-02	8.0e-05	9.1e-05	1.0e-04	4.5e-03
4	YFS	Blood	0.0286	0.0090	5.5e-08	0.028	0.028	0.030	0.030	0.032	1.1e-09	1.3e-09	3.1e-10	4.1e-10	9.8e-11
5	TCGA	Brain Lower Grade Glioma	0.0350	0.0205	1.6e-04	0.030	0.030	0.027	NA	0.026	2.2e-04	2.1e-04	3.8e-04	NA	5.8e-04
6	TCGA	Thyroid Carcinoma	0.0290	0.0220	7.2e-03	0.009	0.015	0.006	NA	0.006	4.3e-02	1.2e-02	7.7e-02	NA	7.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Fluid intelligence score	10.1	21.0	38.4	4.0	4.5	6.2	4.3	3.6	4.5
Alcohol intake frequency.	10.1	23.5	60.5	-4.4	-3.7	-7.8	-4.0	-3.9	-4.0
Handedness (chirality/laterality): Left-handed	8.7	10.4	14.3	-3.3	-3.5	-3.8	-3.0	-2.9	-2.7
Prostate Cancer	7.9	11.1	14.5	3.1	3.5	2.6	3.3	3.8	3.5
Commuting to job workplace: Car/motor vehicle	7.5	8.6	12.8	2.6	2.7	2.4	3.6	2.9	3.3
Commuting to job workplace: Walk	6.7	7.2	8.6	-2.7	-2.7	-2.2	-2.9	-2.7	-2.9
Fasting Glucose	5.9	7.1	7.9	-2.5	-2.7	-2.8	-2.8	-2.5	-2.8
Ulcerative Colitis	5.8	8.5	15.3	-3.1	-2.5	-3.9	-2.9	-2.0	-2.6
Blood White Count	4.7	34.7	40.2	-6.2	-6.2	-4.4	-6.1	-6.3	-5.9
Ulcerative Colitis (UC)	4.5	8.4	18.9	-2.8	-2.3	-4.4	-2.9	-1.9	-2.4
Angina	4.4	5.8	8.4	-2.2	-2.4	-2.0	-2.5	-2.9	-2.4
Angina (self-reported)	4.4	5.8	8.6	-2.2	-2.3	-2.2	-2.5	-2.9	-2.4
Verbal and Numeric Reasoning (VNR)	4.1	9.8	21.3	2.7	2.9	4.6	2.6	2.5	2.8
Irritable Bowel Disease (IBD)	3.9	9.3	28.7	-3.0	-2.0	-5.4	-2.6	-1.6	-2.2
Heart attack	3.8	4.8	7.8	-1.9	-1.9	-2.8	-2.1	-2.5	-1.8
Qualifications: A levels/AS levels or equivalent	3.8	8.4	14.7	3.0	2.5	3.8	2.8	2.4	2.5
Intelligence (Savage-Jansen 2018)	3.7	11.2	33.3	2.8	2.6	5.8	2.7	2.4	2.6
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.6	5.8	2.4	2.3	2.2	2.0	1.7	2.2
Tinnitus: Yes, now most or all of the time	3.5	4.1	6.3	-2.5	-2.2	-1.3	-2.2	-1.2	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	3.4	4.0	6.2	1.8	2.0	2.5	1.7	2.1	1.8
Qualifications: College or University degree	3.3	10.4	31.1	2.6	2.4	5.6	2.2	3.0	2.2
Supplements: Vitamin C	3.2	3.8	4.8	-1.7	-2.0	-1.8	-2.2	-2.2	-1.8
Alcohol usually taken with meals	3.1	5.0	8.9	2.1	1.8	3.0	2.3	2.1	2.0
Alcohol drinker status: Never	3.1	3.7	9.4	-1.6	-1.9	-3.1	-1.5	-1.8	-1.1
Qualifications: O levels/GCSEs or equivalent	2.9	4.7	6.9	2.1	1.9	2.6	2.2	2.2	1.8
Medication: Metformin	2.8	3.9	5.6	1.9	2.3	1.0	2.4	1.9	2.1
Heart attack/myocardial infarction (self-reported)	2.8	3.6	6.3	-1.6	-1.7	-2.5	-1.7	-2.2	-1.6
Qualifications: None of the above	2.7	5.8	13.8	-2.3	-1.9	-3.7	-2.0	-2.0	-2.0
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	6.2	1.9	1.9	2.5	2.1	2.0	1.9
Length of working week for main job	2.6	2.8	4.7	2.2	1.7	1.9	1.7	1.4	1.1
Exposure to tobacco smoke at home	2.6	2.9	3.8	1.9	1.9	1.5	1.6	1.9	1.3
Leg pain on walking	2.6	3.3	5.0	1.7	1.8	2.2	1.7	1.6	1.8
Average weekly red wine intake	2.6	3.8	7.8	1.6	1.3	2.8	2.0	1.9	1.8
Medication: Atorvastatin	2.6	3.3	6.1	-2.5	-2.0	-0.5	-1.7	-1.7	-1.9
Fed-up feelings	2.5	4.5	7.6	-1.9	-1.7	-2.8	-2.0	-2.3	-2.0
Relative age voice broke	2.5	3.8	6.6	-2.3	-2.0	-1.2	-1.9	-2.6	-1.4
Medication: Ibuprofen	2.5	3.0	4.2	2.0	1.7	1.9	1.5	1.2	1.9
Worrier / anxious feelings	2.4	4.6	7.0	-2.4	-1.7	-2.1	-1.8	-2.7	-2.1
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	6.1	1.2	1.6	2.5	1.5	1.4	1.6
Depression (self-reported)	2.4	2.9	3.8	-1.5	-1.4	-2.0	-1.8	-1.5	-1.9
Smoking Status	2.3	5.5	9.3	2.5	2.4	3.0	2.1	1.8	2.0
Knee pain experienced in last month	2.3	3.6	4.7	2.0	2.2	1.6	1.9	1.6	2.1
Health satisfaction	2.2	2.9	4.5	1.8	1.8	2.1	1.3	2.1	0.8
Average weekly beer plus cider intake	2.2	3.2	4.5	-2.1	-1.8	-1.9	-1.4	-1.4	-1.9
Crohns Disease (2012)	2.1	3.3	14.1	-1.3	-0.8	-3.8	-1.3	-0.7	-1.0
Diastolic blood pressure, automated reading	2.1	6.4	9.0	3.0	2.8	1.3	2.5	2.8	2.5
Gout (self-reported)	2.0	2.7	4.1	1.4	1.9	0.9	1.6	2.0	1.8
Average weekly champagne plus white wine intake	2.0	2.7	6.7	1.2	1.1	2.6	1.7	1.2	1.6
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	3.3	1.2	1.8	1.1	1.6	1.6	1.6
Loud music exposure frequency	1.9	2.0	3.3	1.5	1.2	1.8	1.5	1.3	1.1
Medication: Gliclazide	1.9	2.1	3.5	1.3	1.7	0.8	1.9	1.6	1.3
HbA1C	1.8	2.1	5.0	-0.9	-1.5	-2.2	-1.2	-1.3	-1.1
Diabetes (mother)	1.8	2.3	3.8	-1.7	-1.2	-1.5	-1.9	-1.2	-1.4
Ever taken oral contraceptive pill	1.8	2.0	3.7	1.6	1.3	1.9	1.3	0.8	1.3
Age started oral contraceptive pill	1.8	2.3	4.1	-2.0	-1.3	-1.2	-1.6	-1.5	-1.4
Body Mass Index (BMI) (2010)	1.7	2.4	11.2	-0.7	-0.6	-3.3	-0.9	-1.2	-0.3
Townsend deprivation index at recruitment	1.7	2.5	3.2	-1.1	-1.6	-1.6	-1.7	-1.8	-1.5
Diabetes diagnosed by doctor	1.7	2.9	4.2	1.7	2.1	1.4	2.0	1.3	1.6
Osteoporosis (self-reported)	1.7	2.1	3.0	1.7	1.7	1.1	1.3	1.3	1.6
High cholesterol (Self-reported)	1.7	3.0	3.5	-1.8	-1.6	-1.8	-1.8	-1.5	-1.9
Crohns Disease (2017)	1.6	3.6	14.1	-1.8	-0.8	-3.8	-1.3	-0.6	-1.2
Coronary Artery Disease (CAD)	1.6	2.0	5.5	-1.3	-1.5	-2.3	-0.6	-1.2	-0.8
Allergy or Eczema	1.6	4.3	15.4	1.6	1.2	3.9	1.6	1.3	1.3
Miserableness	1.6	2.7	3.3	-1.8	-1.6	-1.8	-1.5	-1.8	-1.3
Multivitamins +/- minerals	1.5	2.0	3.0	-1.6	-1.6	-0.3	-1.6	-1.1	-1.7
Chronic bronchitis/emphysema (father)	1.5	1.7	2.9	-0.5	-1.2	-1.2	-1.4	-1.5	-1.7
Hip circumference	1.5	6.3	37.1	-0.4	-0.4	-6.1	-0.2	-0.3	-0.0
Number of live births	1.5	2.1	7.2	1.0	1.0	2.7	1.0	1.4	0.9
Qualifications: nursing, teaching	1.5	2.4	4.5	2.1	1.4	1.6	1.2	1.4	1.3
Ever had hysterectomy (womb removed)	1.4	1.6	3.0	-1.3	-1.1	0.0	-1.3	-1.7	-1.4
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.2	-1.4	-1.2	-1.5	-1.2	-0.8	-1.2
Alcohol intake versus 10 years previously	1.4	2.2	3.8	-1.5	-1.0	-1.9	-1.6	-1.4	-1.1
Waist Hip Ratio (WHR)	1.3	5.8	7.9	2.4	2.1	1.9	2.8	2.5	2.6
Arm fat percentage (right)	1.3	5.1	28.8	-0.8	-0.5	-5.4	-0.2	-1.0	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.2	-1.8	-1.3	-0.7	-1.5	-1.4	-1.6
Number of children fathered	1.3	1.5	4.6	0.5	1.0	2.1	1.2	0.8	1.1
Had major operations	1.3	1.6	2.3	1.1	1.4	1.3	1.1	1.5	1.1
Arm fat percentage (left)	1.3	5.1	28.7	-0.9	-0.4	-5.4	-0.2	-0.8	-0.0
Worry (Nagel 2018)	1.2	2.4	4.8	-1.4	-1.4	-1.7	-1.2	-2.2	-1.2
Major Depression (MDD)	1.2	1.5	2.2	-0.9	-1.4	-0.1	-1.4	-1.4	-1.5
Ovarian Cancer	1.2	1.5	2.1	-1.4	-1.3	-0.9	-1.4	-1.2	-1.1
Nervous feelings	1.2	2.2	4.1	-1.4	-1.4	-2.0	-1.1	-1.7	-1.1
Arm fat mass (right)	1.2	5.1	29.9	-0.5	-0.3	-5.5	-0.0	-0.4	0.2
Headache pain in last month	1.2	2.0	3.0	-1.4	-1.6	-0.5	-1.6	-1.7	-1.3
Family relationship satisfaction	1.2	1.5	2.6	0.8	1.2	1.4	1.2	1.6	1.0
Trunk fat percentage	1.1	4.2	24.7	-0.6	-0.3	-5.0	0.1	-0.5	0.2
Waist circumference	1.1	4.0	18.5	0.8	0.8	-4.3	1.2	0.9	1.3
Diabetes (self-reported)	1.1	1.7	2.8	1.4	1.6	0.7	1.7	1.1	1.1
Hair/balding pattern: Pattern 3	1.1	1.6	1.8	1.2	1.3	1.4	1.2	1.2	1.4
High blood pressure (siblings)	1.1	1.6	2.9	1.0	1.7	0.5	1.0	1.3	1.6
Arm fat mass (left)	1.1	4.6	27.2	-0.3	-0.0	-5.2	0.2	-0.1	0.4
Medication: Lisinopril	1.1	1.4	2.4	0.9	1.3	0.3	1.5	1.2	1.5
Stomach or abdominal pain in last month	1.0	1.3	3.3	1.0	0.6	1.8	1.0	1.1	0.8
Trunk fat mass	1.0	4.3	25.0	-0.0	0.2	-5.0	0.6	0.3	0.6
Past tobacco smoking	1.0	1.8	6.6	-0.5	-1.3	-2.6	-0.9	-0.8	-0.8
Whole body fat mass	1.0	4.0	23.3	-0.0	0.2	-4.8	0.6	0.3	0.7
Suffer from ‘nerves’	1.0	1.6	6.3	-0.8	-0.8	-2.5	-0.6	-1.2	-0.1
BMI	0.9	5.4	32.0	0.1	-0.2	-5.7	0.1	0.1	0.3
Relative age of first facial hair	0.9	1.9	3.3	-1.8	-1.2	0.1	-1.4	-1.8	-1.2
Vitamin and mineral supplements	0.9	1.2	1.8	1.0	1.1	0.4	1.3	1.3	1.2
High blood pressure (mother)	0.9	1.2	1.9	0.9	1.0	0.8	1.1	1.4	1.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.2	1.0	0.7	1.8	0.8	1.2	0.6
Illnesses of siblings	0.9	1.2	2.6	-0.9	-1.5	-0.5	-0.9	-0.7	-1.6
Weight	0.9	4.5	25.7	0.2	0.3	-5.1	0.6	0.4	0.8
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.7	-0.1	-0.8	-1.6	-0.8	-0.9	-1.1
Body fat percentage	0.9	3.6	20.9	-0.5	-0.1	-4.6	0.2	-0.4	0.3
Comparative body size at age 10	0.9	2.4	11.8	0.7	0.1	-3.4	0.4	0.1	1.3
Mother’s age at death	0.9	1.1	2.1	1.2	1.0	1.5	0.9	0.9	0.7
Lupus	0.8	1.2	2.5	-0.8	-1.6	-0.6	-1.1	-1.1	-1.2
Qualifications: CSEs or equivalent	0.8	1.0	2.6	-0.7	-0.9	-1.6	-0.8	-0.8	-0.8
Serious illness, injury or assault to yourself	0.8	1.0	1.6	1.2	0.9	0.9	0.7	1.3	0.8
Body mass index (BMI)	0.8	3.3	19.8	-0.3	-0.1	-4.5	0.1	-0.2	0.2
Medication: Lansoprazole	0.8	0.9	1.6	1.3	1.2	0.3	0.8	0.9	0.9
Prospective memory result	0.8	1.0	2.4	-0.7	-1.0	-1.5	-0.8	-0.5	-1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.3	-0.8	-1.0	-1.5	-0.8	-0.8	-0.9
Loneliness, isolation	0.8	1.1	2.2	-0.8	-0.9	-1.5	-1.2	-1.0	-0.6
Medication: Aspirin	0.8	1.0	2.5	-0.7	-1.1	-0.0	-1.0	-1.6	-1.0
Eye problems/disorders: Glaucoma	0.8	0.9	3.2	0.1	0.8	1.8	0.6	0.9	0.6
Ever depressed for a whole week	0.8	1.0	2.4	-1.0	-0.8	0.9	-1.0	-0.5	-1.6
Leg fat mass (left)	0.8	3.0	16.9	0.1	0.4	-4.1	0.5	0.4	0.8
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.9	1.1	1.0	0.5	1.7	0.7	1.3
Chronotype (morning person)	0.7	1.6	2.7	1.3	1.6	0.2	1.2	1.4	1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.8	0.7	1.4	0.8	1.0	0.8	1.1
Average weekly fortified wine intake	0.7	0.9	1.2	0.6	0.8	0.9	1.1	1.0	1.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	5.9	1.1	0.6	2.4	0.9	0.7	0.5
Medication: Levothyroxine sodium	0.7	1.2	2.4	0.6	1.3	0.8	1.6	0.8	1.3
Leg predicted mass (left)	0.7	3.4	16.2	0.7	0.7	-4.0	1.0	1.1	1.1
Pulse wave reflection index	0.7	0.8	2.0	0.5	1.1	1.4	0.7	0.8	0.6
Arm fat-free mass (right)	0.7	3.4	5.6	1.6	1.5	-1.9	1.8	2.4	1.9
Leg fat mass (right)	0.7	2.9	14.9	0.3	0.6	-3.9	0.8	0.6	1.0
Arm predicted mass (right)	0.7	3.6	6.0	1.6	1.6	-1.7	1.9	2.4	1.9
Number of full sisters	0.7	0.8	1.5	0.9	0.7	1.2	0.9	0.1	1.2
Chest pain or discomfort	0.7	1.0	1.6	-0.9	-0.9	-0.8	-1.3	-1.0	-1.1
Smoking status: Previous	0.7	1.1	4.4	0.0	0.9	2.1	0.8	0.5	0.6
Ever had bowel cancer screening	0.7	0.9	2.4	-1.5	-0.4	0.5	-1.0	-0.7	-1.0
Ever smoked	0.7	1.2	5.2	0.4	1.1	2.3	0.5	0.4	0.5
Cholesterol lowering medication	0.7	1.0	1.6	-1.3	-0.9	0.1	-1.1	-1.1	-1.1
Heart disease (siblings)	0.7	0.8	1.7	-0.9	-0.8	-0.4	-1.0	-1.3	-0.7
Bipolar Disorder (2011)	0.6	0.5	0.8	0.5	0.8	-0.8	0.6	0.9	0.7
Neuroticism	0.6	1.4	2.3	-1.5	-1.1	-0.8	-1.0	-1.5	-1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	0.7	1.2	0.4	0.9	1.1	1.0
Leg fat-free mass (left)	0.6	3.4	15.8	0.8	0.7	-4.0	1.0	1.1	1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	0.3	1.1	1.2	0.7	0.7	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.2	1.5	1.4	0.4	1.3	1.0	1.1
Supplements: Glucosamine	0.6	0.8	1.8	-0.6	-0.8	-1.3	-0.7	-1.1	-0.6
Medication: Atenolol	0.6	0.8	1.7	-0.7	-0.7	-0.7	-0.8	-0.8	-1.3
Neuroticism score	0.6	1.2	1.5	-1.2	-0.7	-1.2	-1.0	-1.1	-1.1
Trunk fat-free mass	0.6	3.4	5.5	1.8	1.6	-1.7	1.7	2.4	1.8
Falls in the last year	0.6	0.8	2.8	1.1	0.5	1.7	0.8	0.2	0.4
Trunk predicted mass	0.6	3.3	5.5	1.7	1.6	-1.7	1.7	2.4	1.8
Whole body fat-free mass	0.6	3.2	7.2	1.4	1.3	-2.7	1.5	1.9	1.6
Leg fat-free mass (right)	0.6	3.2	16.0	0.7	0.5	-4.0	0.8	0.9	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.7	1.3	1.1	0.3	0.9	0.6	0.6
Breast cancer (self-reported)	0.6	0.8	1.6	-0.7	-0.6	-0.9	-1.3	-0.8	-0.8
Osteoarthritis (self-reported)	0.6	0.7	1.3	0.9	1.2	0.8	0.8	0.2	0.9
Leg predicted mass (right)	0.6	3.2	16.3	0.7	0.5	-4.0	0.8	0.9	1.0
Commuting to job workplace: Public transport	0.6	0.7	2.7	0.6	0.4	1.6	0.6	0.8	0.2
Basal metabolic rate	0.6	3.2	12.0	1.0	0.9	-3.5	1.2	1.4	1.3
Arm fat-free mass (left)	0.6	3.0	4.7	1.5	1.4	-2.2	1.6	2.0	1.7
Mean Putamen Volume	0.5	0.5	3.0	0.2	-0.2	1.7	-0.1	0.1	-0.5
HDL Cholesterol	0.5	0.8	2.0	0.9	1.0	1.4	0.6	0.8	0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	0.7	0.8	1.2	0.5	0.4	0.7
Systolic blood pressure, automated reading	0.5	1.3	2.0	1.3	1.2	0.7	0.9	1.4	1.1
Supplements: Zinc	0.5	0.5	0.8	-0.8	-0.5	0.5	-0.7	-0.8	-0.9
Hand grip strength (right)	0.5	1.3	6.6	0.5	0.6	2.6	0.3	0.6	0.2
Glaucoma (self-reported)	0.5	0.6	1.7	0.1	0.9	1.3	0.5	0.6	0.6
Medication: Amlodipine	0.5	0.7	3.1	-0.7	-0.3	-1.8	-0.6	-0.4	-0.4
Number of full brothers	0.5	0.6	1.5	0.0	0.6	1.2	0.5	1.0	0.6
Hypertension (Self-reported)	0.5	1.5	2.5	0.8	1.6	0.1	1.4	1.2	1.5
Smoking status: Current	0.5	0.8	2.4	1.5	0.8	0.6	0.5	0.7	0.6
Whole body water mass	0.5	3.1	7.1	1.4	1.2	-2.7	1.5	1.9	1.6
Wears glasses or contact lenses	0.5	0.6	1.1	0.6	1.0	-0.1	0.8	0.8	1.0
Leg fat percentage (left)	0.5	1.9	10.9	-0.6	0.1	-3.3	0.0	-0.3	0.2
Unable to work because of sickness or disability	0.5	0.7	2.8	-0.6	-0.6	-1.7	-0.5	-0.5	-0.3
Arm predicted mass (left)	0.5	2.3	7.2	1.0	0.9	-2.7	1.1	1.5	1.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.9	-0.9	-0.8	-1.4	-0.8	-0.8	-1.0
Neuroticism (Nagel 2018)	0.4	0.9	1.5	-0.8	-0.8	-1.2	-0.7	-1.1	-0.9
Blood Eosinophil Count	0.4	3.0	3.8	-1.5	-1.8	-1.7	-1.9	-1.5	-1.9
Number of treatments/medications taken	0.4	0.8	1.3	1.0	1.1	0.6	0.8	0.7	0.9
Pack years adult smoking proportion	0.4	0.5	2.8	-0.1	-0.6	-1.7	-0.4	0.0	-0.2
Current tobacco smoking	0.4	0.7	2.4	1.6	0.8	0.3	0.5	0.5	0.6
Impedance of arm (right)	0.4	2.0	3.7	-1.4	-1.2	-1.5	-1.2	-1.9	-1.2
Noisy workplace	0.4	0.5	1.1	-0.6	-0.8	0.1	-0.8	-0.1	-1.0
Asthma	0.4	0.8	2.1	0.9	0.7	1.5	0.8	0.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.9	-1.4	-1.2	-0.1	-1.2	-0.8	-1.2
Birth weight of first child	0.4	0.7	4.0	0.5	0.0	-2.0	0.1	0.0	0.3
Birth weight	0.4	0.9	1.8	0.7	0.7	-1.0	0.9	1.1	1.4
Leg fat percentage (right)	0.4	1.6	9.0	-0.3	0.3	-3.0	0.3	0.0	0.4
Shortness of breath walking on level ground	0.4	0.5	0.9	-0.6	-0.6	-0.7	-0.6	-0.7	-0.9
Neck or shoulder pain in last month	0.4	0.5	1.9	-0.4	-0.4	1.4	-0.5	-0.5	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.7	-0.5	-0.2	-0.8	-0.7	-0.9
Medication for cholesterol	0.4	0.6	0.9	0.9	0.8	-0.4	0.6	0.8	0.8
Mineral and other dietary supplements	0.4	0.5	0.8	0.6	0.9	0.9	0.5	0.7	0.6
Illnesses of father: None of the above (group 1)	0.4	0.6	1.0	-1.0	-0.7	-0.5	-0.7	-0.5	-0.9
Financial situation satisfaction	0.4	0.5	1.0	-0.9	-0.6	-0.5	-1.0	-0.7	-0.5
Medication: Paracetamol	0.4	0.5	1.8	-0.5	-0.4	-1.4	-0.3	-0.9	0.1
Pain experienced in last month	0.4	0.7	1.5	-1.0	-0.9	-1.2	-0.6	-0.6	-0.6
Supplements: Calcium	0.4	0.5	0.8	-0.4	-0.8	-0.0	-0.9	-0.7	-0.8
Schizophrenia (2018)	0.3	0.5	1.2	-0.4	-1.1	-0.8	-0.8	-0.4	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.8	-0.9	-0.3	0.1	-0.7	-0.0	-0.8
Neuroticism (2016)	0.3	0.4	0.8	0.3	0.9	0.7	0.6	0.4	0.6
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.7	-0.4	0.2	-0.7	-0.9	-0.7
Blood Red Count	0.3	2.6	13.0	-0.6	-0.8	3.6	-0.6	-0.5	-0.8
Systolic Blood Pressure	0.3	1.3	2.1	1.3	1.1	1.2	0.9	1.4	0.7
Respiratory disease	0.3	0.7	1.1	0.9	0.5	1.1	0.9	0.9	0.7
Medication for hormone replacement therapy	0.3	0.3	0.6	0.5	0.2	0.8	0.7	0.6	0.0
Medication: Co-codamol	0.3	0.3	1.3	-0.0	0.2	-1.2	0.1	-0.6	0.3
Diabetes (father)	0.3	0.4	0.9	0.6	0.9	-0.1	0.5	0.8	0.7
Severe depression (siblings)	0.3	0.3	0.6	-0.3	-0.7	-0.1	-0.7	-0.6	-0.5
Impedance of leg (right)	0.3	1.4	8.4	0.0	0.3	2.9	0.1	0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	1.0	0.7	-0.7	0.5	-0.1	0.6
Impedance of leg (left)	0.3	1.3	7.7	0.1	0.1	2.8	0.1	-0.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-0.2	0.4	1.0	0.2	1.0	-0.3
Pain all over the body in last month	0.3	0.3	0.8	0.0	-0.3	-0.9	-0.3	-0.5	-0.8
Medication: Ramipril	0.3	0.4	1.1	-0.8	0.0	-0.8	-0.5	-1.0	-0.1
Pulse rate	0.3	0.5	0.7	-0.5	-0.8	-0.4	-0.8	-0.8	-0.7
Illnesses of mother	0.3	0.3	0.7	-0.6	-0.3	-0.7	-0.4	-0.8	-0.4
Pulse wave Arterial Stiffness index	0.3	0.4	1.6	0.2	0.5	1.3	0.5	0.2	0.3
Impedance of arm (left)	0.3	1.5	2.3	-1.4	-1.0	-1.3	-1.0	-1.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.5	0.5	1.2	0.0	1.1	0.4	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.2	1.1	0.1	-0.2	0.2	0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.6	-0.8	-0.4	-0.7	-0.8	-0.5	-0.6
Pulse wave peak to peak time	0.3	0.4	2.0	0.0	-0.4	-1.4	-0.2	-0.0	-0.1
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.6	0.3	-0.9	0.4	0.2	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.4	0.5	-0.9	0.5	0.7	0.8
Emphysema/chronic bronchitis	0.3	0.3	1.1	-0.3	-0.5	-1.1	-0.5	-0.0	-0.2
Age at last live birth	0.3	0.4	0.8	0.6	0.4	0.8	0.3	0.9	0.6
Medication: Aspirin	0.3	0.4	1.1	-0.1	-0.7	0.6	-0.5	-1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.4	1.2	0.5	-0.8	0.7	0.6	0.9
Eye problems/disorders: Cataract	0.3	0.4	0.8	-0.3	-0.5	0.9	-0.5	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.4	-0.9	-0.1	1.6	-0.3	-0.3	-0.5
Myopia	0.3	0.4	1.9	-0.4	0.6	1.4	0.0	-0.1	0.3
Alzheimer’s Disease (in mother)	0.2	0.3	0.8	0.4	0.2	0.6	0.4	0.3	0.9
Breast Cancer	0.2	0.4	0.6	-0.2	-0.6	0.8	-0.5	-0.7	-0.8
Rheumatoid Arthritis	0.2	0.3	1.3	-0.2	-0.2	-1.2	0.2	-0.5	0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.0	0.4	0.6	0.6	-0.1	0.4
Cardiovascular Disease	0.2	0.7	3.5	-0.5	-0.1	-1.9	-0.4	0.0	-0.3
Hypothyroidism (self reported)	0.2	0.5	2.2	-0.4	0.1	-1.5	0.1	-0.9	0.1
Lung FVC	0.2	0.9	4.6	-0.6	-0.3	2.1	-0.5	-0.3	-0.2
Age when periods started (menarche)	0.2	0.5	1.8	-0.3	-0.2	1.4	-0.2	0.8	-0.3
High blood pressure	0.2	0.5	1.0	-0.0	1.0	-0.3	0.8	0.5	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.5	-0.4	-0.0	1.2	0.0	-0.1	-0.2
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.3	-0.5	0.1	-0.7	-0.8	-0.5
Allergy	0.2	0.6	2.8	-0.5	-0.1	-1.7	-0.4	-0.4	0.1
Time employed in main current job	0.2	0.3	0.8	0.3	0.3	0.2	0.8	-0.2	0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.7	0.9	-0.0	-0.5	-0.1	0.1
Lung cancer (father)	0.2	0.2	1.0	0.2	0.3	-0.2	0.2	1.0	0.3
Standing height	0.2	2.1	3.2	1.3	1.1	-1.8	1.3	1.6	1.4
Breastfed as a baby	0.2	0.3	0.4	-0.5	-0.7	0.5	-0.5	-0.4	-0.6
Tense / ‘highly strung’	0.2	0.3	0.7	-0.3	-0.9	0.7	-0.3	-0.3	-0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.4	-0.7	-0.4	1.2	-0.5	-0.3	-0.7
Peak expiratory flow (PEF)	0.2	0.5	1.0	0.3	0.7	0.6	0.9	0.5	1.0
Forced vital capacity (FVC), Best measure	0.2	0.7	1.0	-1.0	-0.9	-0.5	-0.9	-0.4	-1.0
Wheeze or whistling in the chest in last year	0.2	0.3	1.1	1.0	0.5	-0.3	0.4	0.3	0.4
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	-0.6	-0.8	-0.9	-0.6	0.0	-0.6
Medication: Blood pressure	0.2	0.3	0.6	0.4	0.8	-0.8	0.4	0.3	-0.0
Migraine (self-reported)	0.2	0.2	0.6	0.5	0.5	0.8	0.2	0.4	0.3
Medication: Allopurinol	0.2	0.2	0.7	0.1	0.8	-0.1	0.2	0.8	0.1
Heart disease (mother)	0.2	0.2	0.4	-0.5	-0.6	0.1	-0.5	-0.7	-0.4
Comparative height size at age 10	0.2	1.4	7.0	0.6	0.1	-2.6	0.2	0.6	0.5
Overall health rating	0.2	0.4	0.8	0.7	0.6	-0.5	0.9	0.0	0.5
Long-standing illness, disability or infirmity	0.2	0.2	0.9	-0.4	0.0	-1.0	0.1	-0.6	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.3	-0.2	0.7	-0.1	-0.0	-0.6
Friendships satisfaction	0.2	0.3	0.7	-0.6	-0.4	0.8	-0.6	-0.0	-0.4
Back pain experienced in last month	0.2	0.3	1.1	-0.2	0.1	1.1	0.4	0.0	0.4
Asthma (self-reported)	0.2	0.5	1.4	0.8	0.5	1.2	0.5	0.4	0.2
Guilty feelings	0.2	0.3	0.9	0.6	0.9	0.4	0.5	0.4	0.5
Medication: Blood pressure	0.2	0.4	0.8	-0.9	-0.5	-0.6	-0.4	-0.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	-0.4	-0.4	-0.3	-0.5	-1.0	-0.4
Irritability	0.2	0.3	0.9	-0.1	0.4	1.0	0.4	0.8	0.2
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.2	-0.3	-0.6	-0.6	-0.6	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.5	0.9	-0.0	1.2	0.3	0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.9	0.3	0.1	0.9	0.1	0.3	-0.5
Pack years of smoking	0.2	0.2	1.1	0.2	-0.2	-1.0	-0.1	0.4	0.1
Bipolar Disorder (2018)	0.1	0.2	0.5	-0.1	0.6	-0.7	-0.1	-0.1	0.3
Bipolar Disorder or Schizophrenia	0.1	0.3	1.0	-0.4	-0.5	-1.0	-0.6	-0.4	-0.4
Depression (Nagel 2018)	0.1	0.2	0.4	0.6	0.5	-0.3	0.4	-0.1	0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	0.1	-0.4	0.7	-0.2	0.1	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.5	-0.4	-0.0	-0.5	-0.4	-0.0
Reaction Time	0.1	0.2	0.6	0.7	0.6	0.1	0.0	-0.4	-0.2
Age at First Birth	0.1	0.1	0.3	0.4	0.5	0.3	0.2	-0.0	0.5
Schizophrenia (2014)	0.1	0.1	0.3	0.1	-0.6	-0.2	-0.6	-0.0	-0.3
Triglycerides	0.1	0.1	0.3	0.0	-0.1	-0.5	0.4	-0.1	0.6
Blood Platelet Count	0.1	0.9	3.1	-0.2	-0.6	-1.8	-0.6	-0.9	-0.8
Heel T-Score	0.1	1.2	2.5	0.9	1.3	1.6	0.8	0.9	0.7
Height	0.1	2.0	2.5	1.1	1.4	-1.6	1.3	1.6	1.4
Lung FEV1/FVC ratio	0.1	0.5	1.4	0.6	0.4	1.2	0.5	0.2	0.8
Average weekly spirits intake	0.1	0.1	0.3	-0.1	0.3	0.4	0.1	-0.5	0.2
Sensitivity / hurt feelings	0.1	0.1	0.3	0.1	0.5	0.1	0.4	0.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.4	0.3	0.4	0.5	0.0	0.3
Maternal smoking around birth	0.1	0.1	0.3	0.4	0.6	-0.2	0.2	-0.2	0.5
Taking other prescription medications	0.1	0.2	0.4	0.5	0.7	0.1	0.6	0.3	0.4
Hair/balding pattern: Pattern 2	0.1	0.2	0.6	-0.0	-0.5	-0.3	-0.2	-0.8	0.0
Had menopause	0.1	0.2	0.8	0.1	-0.1	-0.9	-0.1	-0.0	0.4
Had other major operations	0.1	0.2	0.3	0.5	0.6	-0.3	0.2	0.5	0.3
Forced vital capacity (FVC)	0.1	0.3	0.7	-0.9	-0.5	-0.3	-0.7	-0.2	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	0.7	0.7	-0.1	0.7	0.4	0.3
Financial difficulties in last 2 years	0.1	0.2	0.4	-0.5	-0.1	0.5	-0.6	-0.1	-0.5
Mouth/teeth dental problems	0.1	0.2	0.6	0.8	-0.8	-0.1	0.2	-0.1	-0.2
Medication: Simvastatin	0.1	0.1	0.4	0.2	0.2	-0.6	0.0	-0.1	-0.1
Father’s age at death	0.1	0.2	0.5	-0.1	-0.7	0.2	-0.3	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.6	-0.7	-0.3	0.5	-0.3	-0.1	-0.2
Happiness	0.1	0.2	0.3	-0.2	-0.1	0.4	-0.5	0.4	-0.5
Medication: Cholesterol lowering	0.1	0.2	1.1	-0.3	-0.1	-1.1	0.0	-0.1	-0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.6	0.2	-0.5	-0.3	-0.2	-0.2
Blood clot in the leg (DVT)	0.1	0.2	0.8	0.3	0.1	0.9	0.1	0.4	-0.3
Medication: Paracetamol	0.1	0.2	0.5	0.2	0.4	-0.5	0.4	-0.2	0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.1	-0.5	0.6	-0.3	-0.4	0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.3	-0.1	0.5	0.1	0.3	-0.1
Worry too long after embarrassment	0.1	0.2	0.4	-0.1	-0.1	-0.3	-0.4	-0.5	-0.7
Medication: Omeprazole	0.1	0.1	0.2	-0.4	0.4	0.1	0.2	0.2	-0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.5	0.3	-0.0	0.1	-0.0	-0.7	0.0
Mean time to correctly identify matches	0.1	0.3	0.6	0.2	0.2	-0.0	-0.6	-0.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	-0.4	-0.1	0.1	-0.4	-0.1	-0.5
Pulse rate, automated reading	0.1	0.2	0.8	0.1	-0.0	-0.9	-0.3	-0.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.2	0.5	-0.1	0.4	0.2	-0.0
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.1	0.4	0.0	0.3	-0.0	0.7
Mood swings	0.1	0.2	0.6	-0.3	-0.1	-0.8	-0.0	0.3	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.2	0.8	-0.4	0.3	0.3	-0.0
Hearing aid user	0.1	0.1	0.2	-0.1	-0.3	0.2	-0.3	-0.3	-0.5
Medication: Bendroflumethiazide	0.1	0.1	0.5	-0.3	-0.1	-0.7	-0.2	0.0	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.3	0.2	0.1	0.4	0.2	0.3
Risk taking	0.1	0.2	0.6	0.0	-0.3	0.8	-0.4	0.2	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	-0.7	-0.2	0.0	-0.5	-0.2	-0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.6	-0.1	-0.3	-0.8	-0.1	-0.2	0.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.0	0.2	0.6	-0.2	0.2	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.4	-0.1	-0.4	0.0	0.4	-0.1
Impedance of whole body	0.1	0.4	0.9	-0.6	-0.5	0.9	-0.4	-0.8	-0.5
LDL Cholesterol	0.0	0.1	0.1	-0.4	0.3	0.2	-0.3	0.1	-0.2
Hair Pigment	0.0	0.3	0.9	0.3	-0.8	0.9	0.2	-0.2	0.1
Tanning	0.0	0.0	0.1	-0.2	0.1	0.3	0.1	0.1	0.0
Hand grip strength (left)	0.0	0.1	0.3	-0.1	-0.5	0.4	-0.3	0.0	-0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.2	-0.1	-0.0
Sitting height	0.0	0.1	0.1	0.3	0.1	-0.2	0.1	0.3	-0.1
Number of incorrect matches in round	0.0	0.1	0.2	0.5	0.1	0.3	0.2	-0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	-0.0	0.2	-0.3	-0.3	-0.3	-0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.1	-0.4	0.2	0.0	-0.2	-0.1
Age at first live birth	0.0	0.0	0.1	0.0	0.2	-0.3	0.1	-0.1	0.3
Illnesses of father: Heart disease	0.0	0.1	0.1	-0.4	-0.3	-0.3	-0.1	-0.3	0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.2	0.1	-0.0	0.2	0.4	0.4	0.1
Number of operations (self-reported)	0.0	0.1	0.3	-0.1	0.6	-0.1	-0.1	0.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	-0.1	0.2	-0.0	0.2	0.0	-0.1

Hub : Genes

XPO6

Models

Trait associations