Hub : Genes

YAP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0868 0.0319 0.00081 0.071 NA 0.034 NA 0.052 9.5e-06 NA 0.0019 NA 0.00015
2 GTEx Vagina 0.3550 0.1080 0.00210 -0.013 NA -0.003 NA -0.013 9.3e-01 NA 0.3900 NA 0.83000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.5 3.9 7.7 0.3 -2.8
Bipolar Disorder or Schizophrenia 1.3 3.3 6.5 0.2 -2.6
Depressed Affect (Nagel 2018) 0.2 0.4 0.5 -0.6 0.7
Depression (Nagel 2018) 0.1 0.2 0.3 0.2 0.5
Intelligence (Savage-Jansen 2018) 1.3 3.8 7.0 2.6 -0.8
Neuroticism (Nagel 2018) 0.2 0.4 0.7 -0.8 0.4
Schizophrenia (2018) 0.3 0.6 1.1 0.1 -1.0
Schizophrenia vs Biploar Disorder 1.1 1.5 2.8 -0.5 1.7
Worry (Nagel 2018) 0.0 0.0 0.1 -0.0 -0.3
Alzheimer’s Disease (in mother) 0.9 1.1 2.0 1.4 -0.4
Alzheimer’s Disease (in father) 0.7 0.7 1.3 1.2 0.3
Alzheimer’s Disease (including proxy) 0.6 0.8 1.6 1.3 0.2
Crohns Disease (2017) 0.8 1.8 2.1 1.4 -1.2
Irritable Bowel Disease (IBD) 0.4 0.9 1.6 1.2 0.5
Ulcerative Colitis (UC) 1.2 2.3 4.1 0.7 2.0
Major Depression (MDD) 1.2 1.4 2.2 0.8 1.5
Reaction Time 1.4 2.7 4.6 -2.1 0.9
Verbal and Numeric Reasoning (VNR) 1.2 2.9 5.3 2.3 -0.6
Breast Cancer 0.2 0.4 0.7 -0.8 0.3
Ovarian Cancer 1.7 2.2 4.3 -2.1 -0.4
Prostate Cancer 0.3 0.4 0.7 0.9 0.0
Age at First Birth 1.2 1.7 3.4 0.3 -1.8
Bipolar Disorder (2011) 3.7 3.6 6.1 1.1 -2.5
Body Mass Index (BMI) (2010) 0.6 0.8 1.4 -0.5 1.2
Coronary Artery Disease (CAD) 6.5 7.7 15.4 -3.9 0.3
Crohns Disease (2012) 0.3 0.5 1.0 1.0 -0.3
Mean Putamen Volume 0.6 0.6 1.1 1.0 0.5
Fasting Glucose 1.3 1.6 1.6 1.2 1.3
HbA1C 0.1 0.2 0.3 0.5 -0.2
HDL Cholesterol 0.3 0.4 0.9 0.2 0.9
LDL Cholesterol 1.9 3.0 5.9 -2.4 -0.4
Lupus 1.5 2.2 3.7 -1.9 -0.9
Neuroticism (2016) 0.7 1.0 1.5 -1.2 0.6
Primary Biliary Cirrhosis 1.7 2.5 4.2 0.8 2.1
Rheumatoid Arthritis 0.8 1.1 2.0 0.4 1.4
Schizophrenia (2014) 0.2 0.3 0.7 -0.1 -0.8
Triglycerides 0.1 0.2 0.3 -0.6 0.1
Type 2 Diabetes (T2D) (2012) 1.5 1.7 2.6 1.6 -0.9
Ulcerative Colitis 1.6 2.4 3.3 1.2 1.8
Blood Eosinophil Count 1.0 7.6 13.2 -3.6 -1.4
Blood Platelet Count 0.7 7.9 15.8 -4.0 0.0
Blood Red Count 0.4 3.9 7.7 -0.2 2.8
Blood White Count 2.1 15.7 30.1 -5.5 1.1
Heel T-Score 0.2 1.9 2.1 1.3 1.4
BMI 0.8 4.9 6.8 -1.7 2.6
Height 0.5 10.3 20.6 -4.5 0.3
Waist Hip Ratio (WHR) 0.2 1.1 1.1 1.0 1.1
Systolic Blood Pressure 0.4 1.9 3.7 -1.9 0.3
Smoking Status 0.5 1.2 2.3 1.5 -0.3
Allergy or Eczema 0.1 0.2 0.3 -0.6 0.3
Cardiovascular Disease 0.7 2.1 4.2 0.2 2.1
Hypothyroidism (self reported) 0.1 0.2 0.2 0.5 -0.5
Respiratory disease 0.1 0.2 0.4 -0.3 0.6
Type 2 Diabetes (T2D) (2018) 1.3 2.5 3.6 1.9 1.1
Lung FEV1/FVC ratio 0.3 1.6 3.1 -1.8 -0.1
Lung FVC 0.0 0.1 0.1 0.4 -0.4
Neuroticism 0.3 0.8 1.2 -0.6 1.1
Chronotype (morning person) 0.1 0.2 0.3 -0.5 -0.3
Hair Pigment 0.1 3.1 6.1 -0.1 -2.5
Tanning 0.0 0.5 0.6 -0.6 0.8
Hand grip strength (left) 1.9 4.9 7.2 -2.7 -1.6
Number of treatments/medications taken 3.7 6.7 11.0 1.5 3.3
Average weekly spirits intake 0.2 0.2 0.5 0.1 -0.7
Sensitivity / hurt feelings 0.4 0.7 0.8 -0.9 0.8
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.4 0.6 0.3
Hearing difficulty/problems: Yes 1.4 2.1 3.9 0.6 2.0
Relative age of first facial hair 0.5 1.1 1.6 -1.3 -0.7
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 4.0 1.3 2.0
Ever used hormone-replacement therapy (HRT) 2.5 3.1 4.6 -2.1 1.3
Ever had hysterectomy (womb removed) 0.6 0.7 1.1 0.6 1.1
Systolic blood pressure, automated reading 1.0 2.9 4.7 -2.2 1.0
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 2.3 -1.5 1.4
Angina 0.6 0.7 1.2 -1.1 0.5
Medication for hormone replacement therapy 3.5 4.0 5.8 -1.4 2.4
Vitamin and mineral supplements 1.1 1.5 2.4 -1.6 -0.8
Supplements: Zinc 1.4 1.6 1.7 -1.3 1.2
Medication: Co-codamol 2.9 3.4 3.7 1.8 1.9
Medication: Metformin 0.4 0.5 0.8 0.9 -0.5
Diabetes (father) 0.7 0.9 1.8 0.2 1.3
Diabetes (mother) 0.7 0.9 1.9 -1.4 -0.1
Severe depression (siblings) 0.3 0.4 0.5 -0.7 0.4
Pack years adult smoking proportion 0.4 0.6 0.7 0.7 0.8
Impedance of leg (right) 0.1 0.6 1.0 1.0 -0.4
Leg fat-free mass (left) 0.9 4.6 9.1 -3.0 0.5
Trunk fat percentage 0.6 2.4 3.7 -1.1 1.9
Hand grip strength (right) 1.7 4.5 6.5 -2.5 -1.6
Townsend deprivation index at recruitment 0.3 0.4 0.7 -0.8 -0.2
Current tobacco smoking 0.0 0.0 0.1 -0.0 0.2
Average weekly fortified wine intake 2.0 2.4 4.8 -0.0 2.2
Maternal smoking around birth 1.2 1.8 3.6 -0.2 -1.9
Fed-up feelings 0.6 1.0 1.4 -0.8 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.2 0.4 1.5
Relative age voice broke 0.0 0.0 0.1 -0.2 -0.1
Taking other prescription medications 3.1 4.8 8.0 1.3 2.8
Age when periods started (menarche) 5.1 12.3 24.6 0.2 -5.0
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 -0.7 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.0 0.0 -0.2 0.1
Tinnitus: Yes, but not now, but have in the past 1.4 1.4 1.6 -1.1 1.3
Qualifications: CSEs or equivalent 2.0 2.6 5.2 -2.3 0.3
Serious illness, injury or assault to yourself 0.6 0.7 1.1 0.5 1.1
High blood pressure 0.1 0.3 0.4 -0.4 0.7
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 -0.4 -0.2
Multivitamins +/- minerals 0.7 0.9 0.9 1.0 0.9
Stomach or abdominal pain in last month 0.1 0.1 0.2 0.5 -0.2
Supplements: Glucosamine 2.6 3.4 6.8 2.6 -0.1
Diverticular disease/diverticulitis (self-reported) 2.2 2.7 3.8 -1.9 1.2
Medication: Atenolol 0.0 0.0 0.0 0.1 0.2
Medication: Levothyroxine sodium 0.3 0.6 1.0 1.0 0.3
Sitting height 0.1 0.5 0.9 0.9 0.4
Chronic bronchitis/emphysema (father) 2.1 2.5 4.5 -0.7 2.1
High blood pressure (mother) 0.7 1.0 1.8 0.4 1.3
Body mass index (BMI) 1.5 6.3 9.6 -3.1 1.7
Impedance of leg (left) 0.1 0.6 0.8 0.9 -0.7
Leg predicted mass (left) 0.9 4.7 9.3 -3.0 0.5
Trunk fat mass 1.0 4.2 4.4 -2.1 2.0
Waist circumference 2.3 8.4 12.5 -3.5 2.1
Number of incorrect matches in round 0.2 0.3 0.5 -0.7 0.3
Past tobacco smoking 0.6 1.0 2.1 -1.4 0.1
Alcohol usually taken with meals 2.1 3.4 5.2 1.3 -2.3
Nervous feelings 0.1 0.3 0.5 -0.2 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.3 -0.4 1.1
Hearing difficulty/problems with background noise 1.6 2.5 4.7 -0.6 2.2
Hair/balding pattern: Pattern 2 1.9 2.4 4.8 2.2 0.4
Had menopause 0.0 0.0 0.0 -0.1 -0.0
Had other major operations 0.2 0.2 0.5 0.7 -0.1
Forced vital capacity (FVC) 0.0 0.2 0.3 0.3 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 -0.2 0.7
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 2.5 0.7 1.6
Qualifications: None of the above 3.4 7.2 7.7 -2.8 2.6
Financial difficulties in last 2 years 0.3 0.4 0.7 0.8 0.2
Mouth/teeth dental problems 0.1 0.2 0.5 0.7 0.0
Heart attack 0.3 0.3 0.4 -0.6 -0.6
Allergy 0.1 0.2 0.3 -0.3 -0.6
Pain all over the body in last month 0.7 0.8 1.5 -0.1 1.2
Diabetes (self-reported) 0.9 1.4 2.7 -0.4 1.6
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 -0.5 0.1
Medication: Ramipril 1.8 2.3 4.1 -2.0 -0.7
Medication: Simvastatin 1.8 2.7 4.2 -1.0 2.1
Fluid intelligence score 2.0 4.1 7.9 2.8 0.5
Illnesses of siblings 0.2 0.3 0.3 0.6 -0.4
Neuroticism score 0.5 1.1 1.9 -0.6 1.4
Weight 1.6 7.7 13.0 -3.6 1.6
Impedance of arm (right) 2.1 10.0 19.7 4.4 0.5
Arm fat percentage (right) 0.8 3.1 5.2 -1.0 2.3
Trunk fat-free mass 1.3 7.7 15.4 -3.9 0.0
Hip circumference 1.5 6.6 11.4 -3.4 1.4
Time employed in main current job 0.1 0.1 0.2 -0.4 0.4
Alcohol intake versus 10 years previously 2.3 3.5 6.9 -2.6 0.3
Father’s age at death 0.9 1.2 2.3 1.5 0.4
Worrier / anxious feelings 0.1 0.1 0.2 -0.4 -0.1
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 2.9 1.2 1.7
Falls in the last year 0.4 0.5 0.6 0.8 -0.6
Hair/balding pattern: Pattern 3 3.7 5.5 9.8 -3.1 1.1
Number of live births 1.3 1.8 3.5 -1.9 0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.6 -0.2 -0.8
Pulse rate 2.2 3.7 7.4 2.7 0.3
Happiness 1.7 2.0 3.1 1.8 -1.0
Noisy workplace 0.1 0.1 0.1 0.3 -0.3
Qualifications: A levels/AS levels or equivalent 1.6 3.5 5.2 2.3 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.2 -0.5 -0.3
Mouth/teeth dental problems: Dentures 1.3 2.2 4.2 -2.0 0.5
Asthma 0.1 0.2 0.3 0.6 -0.0
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.6 4.4 2.1 0.9
Medication: Cholesterol lowering 1.2 1.8 3.4 0.5 1.8
Depression (self-reported) 1.0 1.2 2.0 0.6 1.4
Medication: Lansoprazole 1.5 1.7 3.1 -0.5 1.8
Prospective memory result 1.1 1.4 1.5 -1.2 1.1
Lung cancer (father) 0.9 1.0 2.0 -1.4 -0.1
Illnesses of mother 3.2 4.0 6.8 -1.1 -2.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.8 -0.1 -0.9
Pulse wave Arterial Stiffness index 1.7 2.0 3.9 0.1 2.0
Impedance of arm (left) 2.0 9.4 18.6 4.3 0.4
Arm fat mass (right) 1.2 4.9 6.4 -2.5 1.9
Trunk predicted mass 1.3 7.4 14.9 -3.9 -0.0
Standing height 0.1 0.9 1.5 -1.2 -0.5
Length of working week for main job 0.2 0.2 0.4 0.6 -0.3
Exposure to tobacco smoke at home 0.3 0.3 0.6 -0.3 0.7
Breastfed as a baby 0.7 0.9 1.2 -0.8 -1.1
Tense / ‘highly strung’ 0.6 1.1 2.0 0.3 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.1 -0.3 1.8
Hair/balding pattern: Pattern 4 1.5 3.6 6.5 -2.5 -0.9
Birth weight of first child 13.5 24.4 44.1 6.6 -2.2
Peak expiratory flow (PEF) 1.3 3.1 6.1 -2.5 -0.3
Pulse wave reflection index 3.2 4.0 7.9 0.2 2.8
Ever highly irritable/argumentative for 2 days 3.5 4.2 6.5 -1.4 2.5
Loud music exposure frequency 1.0 1.1 2.0 0.4 1.4
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 2.8 1.1 -1.7
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 1.6 1.2 -0.7
Blood clot in the leg (DVT) 1.4 1.7 1.9 1.4 1.3
Medication: Paracetamol 1.5 2.5 4.2 0.8 2.1
Headache pain in last month 1.1 2.0 3.6 1.9 0.5
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 3.4 -0.3 -1.8
Glaucoma (self-reported) 0.8 0.9 1.7 1.3 -0.3
Gout (self-reported) 0.1 0.1 0.1 0.1 0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 0.8 -0.2
Medication: Amlodipine 1.3 1.8 3.5 1.9 -0.2
Medication: Ventolin 100micrograms inhaler 0.9 1.2 2.3 -1.5 -0.1
Birth weight 7.8 16.9 30.9 5.6 -1.7
Chronic bronchitis/emphysema (mother) 0.7 0.8 0.9 -0.9 0.8
High blood pressure (siblings) 0.5 0.8 1.4 -1.2 0.3
Forced vital capacity (FVC), Best measure 0.0 0.1 0.3 0.5 -0.1
Body fat percentage 0.9 3.5 4.9 -1.5 2.2
Leg fat percentage (right) 1.5 5.3 6.5 -2.5 2.0
Arm fat-free mass (right) 2.0 10.3 20.4 -4.5 -0.3
Exposure to tobacco smoke outside home 1.0 1.3 2.7 -0.0 1.6
Comparative body size at age 10 0.0 0.1 0.2 0.2 -0.5
Number of full brothers 1.2 1.4 2.1 -1.4 -0.9
Worry too long after embarrassment 0.1 0.1 0.1 -0.4 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 2.2 1.5 -0.6
Wheeze or whistling in the chest in last year 0.7 1.2 2.2 -1.5 0.6
Number of children fathered 0.8 0.9 1.7 1.3 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.8 0.7 0.9
Age at first live birth 1.6 2.8 4.1 2.0 -1.2
Pulse wave peak to peak time 1.5 1.8 3.5 -0.3 -1.9
Health satisfaction 1.3 1.7 3.1 0.5 1.8
Shortness of breath walking on level ground 2.9 3.5 6.8 -0.3 2.6
Qualifications: College or University degree 3.6 11.3 19.9 4.5 -1.7
Eye problems/disorders: None of the above 1.2 1.4 1.7 -1.3 -1.0
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.8 0.2 -0.9
Emphysema/chronic bronchitis 1.4 1.6 2.6 1.6 0.8
Medication for pain relief, constipation, heartburn 1.6 2.8 4.8 -0.8 -2.2
Neck or shoulder pain in last month 0.4 0.6 1.1 -1.1 -0.2
Medication: Blood pressure 0.0 0.1 0.2 -0.1 0.4
Angina (self-reported) 0.5 0.6 1.1 -1.0 0.3
Migraine (self-reported) 3.2 3.9 6.4 2.5 1.2
Medication: Ibuprofen 2.1 2.5 4.6 2.1 0.6
Medication: Allopurinol 0.2 0.3 0.4 0.6 -0.4
Medication: Omeprazole 0.8 0.9 1.9 0.1 1.4
Medication: Seretide 50 evohaler 0.9 1.1 1.2 1.0 1.1
Mean time to correctly identify matches 2.5 4.8 8.5 -2.9 1.1
Heart disease (mother) 0.0 0.0 0.0 0.2 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.2 -0.3 0.5
Whole body fat mass 1.1 4.7 5.8 -2.4 1.9
Leg fat mass (right) 1.7 6.8 10.6 -3.2 1.7
Arm predicted mass (right) 2.0 10.5 20.9 -4.6 -0.2
Pulse rate, automated reading 4.0 12.9 23.3 4.8 1.6
Alcohol intake frequency. 1.1 2.6 4.1 -2.0 1.1
Comparative height size at age 10 1.7 9.5 13.0 -2.5 3.6
Number of full sisters 3.5 4.3 8.3 -2.9 -0.5
Suffer from ‘nerves’ 0.5 0.9 1.4 -1.2 0.6
Overall health rating 2.5 5.3 10.5 -0.4 3.2
Chest pain or discomfort 0.4 0.6 0.8 0.6 -0.9
Had major operations 0.2 0.2 0.2 -0.5 -0.4
Age at last live birth 1.0 1.5 2.5 1.6 0.6
Family relationship satisfaction 1.3 1.6 2.8 1.7 -0.7
Leg pain on walking 1.8 2.3 2.7 1.6 1.4
Qualifications: NVQ or HND or HNC or equivalent 3.0 3.6 5.4 -1.4 2.3
Commuting to job workplace: Car/motor vehicle 0.6 0.7 0.8 -0.9 0.8
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 1.0 -0.2
Medication: Aspirin 1.3 1.7 3.3 -0.4 1.8
Supplements: Vitamin C 1.1 1.3 2.4 1.5 -0.4
Knee pain experienced in last month 7.1 11.0 12.4 -3.1 3.5
Hypertension (Self-reported) 0.0 0.1 0.2 -0.0 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 1.6 -1.3 0.7
Illnesses of father: Heart disease 1.7 2.4 3.4 -1.2 -1.8
Illnesses of siblings: Diabetes 0.5 0.6 0.6 -0.8 0.7
Smoking status: Previous 0.1 0.2 0.4 0.6 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.9 2.0 2.8 1.1 -1.7
Whole body fat-free mass 1.2 7.1 14.2 -3.8 0.3
Leg fat-free mass (right) 0.8 4.5 8.9 -3.0 0.3
Arm fat percentage (left) 0.8 3.3 5.5 -1.1 2.4
Average weekly red wine intake 0.0 0.0 0.0 0.2 0.1
Handedness (chirality/laterality): Left-handed 2.7 3.3 6.1 2.5 0.7
Mood swings 0.0 0.0 0.1 0.1 0.3
Loneliness, isolation 1.9 2.7 3.7 -1.3 1.9
Long-standing illness, disability or infirmity 2.2 3.4 4.3 1.6 2.1
Ever had bowel cancer screening 2.3 2.7 3.6 -1.9 1.3
Diabetes diagnosed by doctor 0.9 1.5 2.8 -0.3 1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 1.8 0.6 -1.3
Friendships satisfaction 0.7 0.9 1.4 1.2 0.6
Qualifications: nursing, teaching 0.4 0.6 1.2 1.1 0.4
Commuting to job workplace: Walk 1.4 1.5 2.3 -0.9 -1.5
Eye problems/disorders: Cataract 1.3 1.5 2.2 1.5 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 0.3 0.0
Medication for cholesterol 2.7 4.1 7.3 0.9 -2.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.6 -0.8 0.6
Back pain experienced in last month 0.3 0.5 1.0 -1.0 0.0
Mineral and other dietary supplements 1.3 1.7 3.3 -1.8 -0.4
Breast cancer (self-reported) 0.1 0.1 0.2 0.5 0.1
Asthma (self-reported) 0.0 0.0 0.1 0.3 0.0
Osteoporosis (self-reported) 2.4 3.0 5.9 2.4 -0.3
Osteoarthritis (self-reported) 1.5 2.0 2.3 1.3 1.5
Medication: Aspirin 0.8 1.1 2.2 -0.1 1.5
Medication: Gliclazide 0.3 0.3 0.5 0.7 -0.4
Illnesses of father: None of the above (group 1) 0.9 1.1 2.1 0.4 -1.5
Smoking status: Current 0.0 0.0 0.1 0.3 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 0.9 1.0 -0.7
Whole body water mass 1.3 7.5 15.0 -3.9 0.2
Leg predicted mass (right) 0.9 4.6 9.0 -3.0 0.3
Arm fat mass (left) 1.1 4.6 6.4 -2.5 1.6
Number of self-reported non-cancer illnesses 1.9 3.3 6.3 0.6 2.5
Average weekly champagne plus white wine intake 6.8 9.3 11.8 3.4 -2.6
Miserableness 0.2 0.4 0.7 -0.2 0.9
Guilty feelings 0.3 0.4 0.4 -0.6 0.6
Wears glasses or contact lenses 1.4 1.6 3.1 -1.8 -0.3
Ever taken oral contraceptive pill 2.4 2.7 4.4 -2.1 -1.0
Hearing aid user 0.9 1.0 1.8 0.5 1.3
Mother’s age at death 0.5 0.7 1.1 1.0 -0.5
Financial situation satisfaction 0.6 0.7 1.1 0.5 1.1
Tinnitus: Yes, now most or all of the time 1.4 1.7 3.3 1.8 -0.0
Commuting to job workplace: Public transport 1.6 1.9 3.8 -0.2 -1.9
Eye problems/disorders: Glaucoma 0.8 0.9 1.2 0.8 1.1
Medication: Blood pressure 0.1 0.1 0.2 0.1 0.5
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.7 -0.8 0.4
Supplements: Fish oil (including cod liver oil) 1.7 2.2 4.1 2.0 0.6
High cholesterol (Self-reported) 2.0 3.5 5.4 -1.3 2.3
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.2 0.4
Medication: Paracetamol 1.3 2.0 2.7 1.1 1.6
Medication: Lisinopril 0.9 1.2 2.3 1.5 0.3
Medication: Atorvastatin 0.3 0.3 0.5 -0.4 0.7
Illnesses of father: High blood pressure 0.1 0.1 0.2 0.5 -0.0
Alcohol drinker status: Never 0.1 0.1 0.1 0.1 0.4
Ever smoked 1.0 1.7 2.1 1.5 -1.1
Basal metabolic rate 1.4 7.7 15.1 -3.9 0.5
Leg fat percentage (left) 1.5 5.4 7.3 -2.7 1.9
Arm fat-free mass (left) 2.2 11.0 22.0 -4.7 -0.1
Number of operations (self-reported) 0.4 0.6 1.1 1.1 -0.3
Average weekly beer plus cider intake 1.4 2.0 3.7 -0.7 1.9
Irritability 0.1 0.2 0.3 -0.3 0.6
Risk taking 0.8 1.2 1.5 1.2 -0.9
Ever had prostate specific antigen (PSA) test 1.8 2.1 2.5 1.6 -1.3
Fractured/broken bones in last 5 years 4.7 6.1 6.3 2.4 -2.5
Age started oral contraceptive pill 0.6 0.7 1.4 1.2 -0.2
Diastolic blood pressure, automated reading 0.7 2.2 3.9 2.0 0.7
Ever depressed for a whole week 0.5 0.6 1.0 1.0 -0.3
Unable to work because of sickness or disability 1.8 2.3 2.5 1.6 1.4
Commuting to job workplace: Cycle 0.5 0.6 1.1 1.0 -0.5
Myopia 0.8 1.2 1.9 -0.6 -1.4
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.7 0.8 -0.4
Cholesterol lowering medication 3.9 5.8 5.9 -2.4 2.4
Medication: Omeprazole (e.g. Zanprol) 2.3 2.8 5.5 -0.2 2.3
Pain experienced in last month 1.3 2.2 2.3 1.5 -1.5
Supplements: Calcium 1.8 2.0 3.3 1.8 -0.9
Basal cell carcinoma (self-reported) 0.5 0.5 0.7 0.7 0.8
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.7 -0.6 -0.8
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 2.0 1.4 1.4
Heart disease (siblings) 1.1 1.4 1.4 -1.2 -1.2
Alcohol drinker status: Previous 0.0 0.0 0.0 -0.1 -0.1
Pack years of smoking 0.1 0.2 0.3 0.1 0.6
Impedance of whole body 1.1 5.4 10.7 3.3 -0.4
Leg fat mass (left) 1.8 7.2 11.4 -3.4 1.7
Arm predicted mass (left) 2.0 10.3 20.5 -4.5 -0.3