Hub : Genes

YIF1B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0580 0.0240 0.00220 0.007 0.03 0.019 0.03 0.005 4.0e-02 0.00014 0.00170 0.00014 6.4e-02
2 GTEx Nerve Tibial 0.0996 0.0389 0.00096 0.033 NA 0.037 NA 0.019 2.2e-03 NA 0.00120 NA 1.6e-02
3 GTEx Skin Sun Exposed Lower leg 0.0520 0.0240 0.00690 0.076 NA 0.045 NA 0.064 7.1e-07 NA 0.00011 NA 5.2e-06
4 GTEx Whole Blood 0.0980 0.0330 0.00016 0.032 NA 0.004 NA 0.024 5.5e-04 NA 0.12000 NA 2.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.1 1.7 3.3 -1.5 0.6 1.8 -0.9
Bipolar Disorder or Schizophrenia 1.7 4.2 6.7 -2.6 1.8 2.3 -1.1
Depressed Affect (Nagel 2018) 0.4 0.9 2.2 0.9 0.4 -1.5 0.5
Depression (Nagel 2018) 0.3 0.4 0.9 0.5 -0.3 -0.6 1.0
Intelligence (Savage-Jansen 2018) 1.0 3.0 10.4 -3.2 -0.7 0.6 0.9
Neuroticism (Nagel 2018) 1.1 2.5 5.6 1.6 -0.6 -2.4 1.1
Schizophrenia (2018) 1.3 2.8 4.5 -2.1 1.9 1.5 -0.7
Schizophrenia vs Biploar Disorder 0.2 0.3 0.8 -0.2 -0.5 -0.9 0.4
Worry (Nagel 2018) 1.8 3.7 5.9 1.8 -1.9 -2.4 1.4
Alzheimer’s Disease (in mother) 0.9 1.1 2.7 0.9 -0.9 0.0 1.6
Alzheimer’s Disease (in father) 1.0 1.1 3.1 0.4 -1.8 -0.9 0.4
Alzheimer’s Disease (including proxy) 0.4 0.6 1.3 -0.0 -1.1 0.2 1.0
Crohns Disease (2017) 0.6 1.4 1.9 1.4 1.4 1.3 -0.3
Irritable Bowel Disease (IBD) 1.2 2.9 4.8 1.0 2.2 1.9 -1.4
Ulcerative Colitis (UC) 0.6 1.2 1.6 -0.1 1.3 1.3 -1.2
Major Depression (MDD) 0.5 0.6 2.1 -0.2 -0.1 1.4 -0.6
Reaction Time 0.5 0.9 1.6 -0.3 -0.8 -1.3 1.1
Verbal and Numeric Reasoning (VNR) 1.6 3.8 11.1 -3.3 0.6 1.7 -0.8
Breast Cancer 0.3 0.6 1.3 0.9 1.1 -0.4 -0.5
Ovarian Cancer 0.4 0.6 1.4 0.0 0.9 1.2 0.2
Prostate Cancer 5.4 7.6 13.0 -1.9 3.6 3.2 -1.8
Age at First Birth 0.1 0.2 0.5 -0.1 0.7 -0.0 -0.3
Bipolar Disorder (2011) 0.2 0.2 0.8 -0.9 0.1 0.3 -0.0
Body Mass Index (BMI) (2010) 0.8 1.0 2.1 -1.4 0.5 1.3 -0.5
Coronary Artery Disease (CAD) 0.2 0.3 0.7 -0.2 -0.8 -0.6 0.2
Crohns Disease (2012) 0.2 0.3 1.2 0.0 0.2 1.1 -0.3
Mean Putamen Volume 0.7 0.8 2.6 -0.4 -0.6 -0.0 1.6
Fasting Glucose 1.7 2.1 4.2 1.0 -1.4 -0.9 2.1
HbA1C 0.8 0.9 1.7 1.3 1.2 -0.4 -0.5
HDL Cholesterol 0.1 0.1 0.2 0.2 0.1 -0.5 0.2
LDL Cholesterol 0.0 0.0 0.0 -0.0 0.1 0.0 -0.2
Lupus 0.6 0.9 2.1 -0.6 0.8 -0.5 -1.5
Neuroticism (2016) 1.4 2.0 3.8 1.9 -0.3 -1.7 1.2
Primary Biliary Cirrhosis 0.2 0.2 0.5 0.2 0.6 -0.1 -0.7
Rheumatoid Arthritis 0.8 1.1 2.3 -1.5 0.8 0.7 -0.9
Schizophrenia (2014) 1.5 3.3 6.1 -2.5 2.1 1.5 -0.6
Triglycerides 0.1 0.2 0.4 -0.6 -0.6 -0.3 0.2
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.4 -0.5 -0.7 -0.5 0.4
Ulcerative Colitis 0.8 1.2 3.1 0.3 1.2 0.5 -1.8
Blood Eosinophil Count 0.4 3.0 8.6 -0.7 -2.9 -1.7 0.3
Blood Platelet Count 5.6 65.2 127.7 3.4 -8.4 -11.3 7.1
Blood Red Count 0.2 1.6 2.6 1.1 1.5 0.7 -1.6
Blood White Count 0.1 0.8 2.0 0.2 0.7 -1.4 -0.8
Heel T-Score 0.1 0.7 1.3 0.6 1.2 0.7 -0.8
BMI 0.4 2.4 5.5 -1.7 0.3 -1.0 -2.4
Height 0.1 1.4 4.2 -1.0 0.1 2.0 0.6
Waist Hip Ratio (WHR) 0.7 3.1 7.8 -1.2 2.8 1.4 -1.0
Systolic Blood Pressure 0.6 3.2 5.5 -0.1 2.4 1.6 -2.1
Smoking Status 1.2 2.8 8.9 -0.9 3.0 0.4 -1.1
Allergy or Eczema 0.5 1.4 2.4 1.3 -1.1 -0.2 1.5
Cardiovascular Disease 0.3 0.8 2.2 -0.9 0.4 0.5 -1.5
Hypothyroidism (self reported) 0.2 0.5 1.2 -0.2 -0.7 -0.3 1.1
Respiratory disease 0.3 0.8 0.9 -1.0 -0.9 0.9 0.8
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 -0.2 0.1 -0.3 -0.8
Lung FEV1/FVC ratio 0.2 1.2 3.3 -1.8 -0.9 -0.7 -0.4
Lung FVC 0.1 0.3 0.6 -0.2 0.5 -0.4 -0.8
Neuroticism 1.6 3.8 7.6 1.7 -1.2 -2.8 1.8
Chronotype (morning person) 0.8 1.8 4.3 2.1 -1.0 -0.3 1.3
Hair Pigment 0.2 6.3 17.9 4.2 -1.7 -1.7 1.2
Tanning 0.0 0.0 0.1 0.2 -0.3 -0.2 -0.1
Hand grip strength (left) 0.2 0.6 1.4 1.0 -1.2 -0.2 -0.3
Number of treatments/medications taken 0.1 0.1 0.5 -0.7 -0.1 0.3 -0.3
Average weekly spirits intake 0.2 0.3 1.0 -0.4 -1.0 -0.1 0.1
Sensitivity / hurt feelings 1.1 1.8 5.9 0.9 -0.8 -2.4 0.1
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.4 0.0 0.6 0.5 -0.3
Hearing difficulty/problems: Yes 0.1 0.2 0.4 0.4 0.6 0.2 -0.5
Relative age of first facial hair 0.1 0.1 0.4 0.6 0.1 0.2 -0.0
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 0.0 -0.1 0.6 -0.6
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.6 -0.3 1.1 1.3 -0.5
Ever had hysterectomy (womb removed) 1.5 1.7 3.7 -0.9 0.8 1.9 -1.2
Systolic blood pressure, automated reading 0.6 1.7 2.4 -0.9 1.4 1.5 -1.2
Eye problems/disorders: Diabetes related eye disease 1.6 1.8 2.8 1.5 -1.4 -1.7 0.4
Angina 0.7 1.0 2.5 0.2 -1.2 -1.6 0.1
Medication for hormone replacement therapy 0.5 0.5 1.5 -0.2 -1.2 -0.4 0.7
Vitamin and mineral supplements 0.1 0.1 0.2 -0.1 -0.1 0.5 -0.2
Supplements: Zinc 0.2 0.3 0.5 0.6 -0.3 -0.7 -0.4
Medication: Co-codamol 2.2 2.6 3.7 -1.7 1.7 1.0 -1.9
Medication: Metformin 0.0 0.0 0.1 0.3 0.0 -0.3 -0.0
Diabetes (father) 1.8 2.2 3.4 -1.5 1.8 1.6 -0.8
Diabetes (mother) 0.6 0.7 2.7 -1.6 -0.1 0.4 -0.1
Severe depression (siblings) 0.3 0.3 0.7 0.5 -0.2 0.6 0.8
Pack years adult smoking proportion 0.3 0.5 1.2 0.6 0.6 -1.1 -0.2
Impedance of leg (right) 0.2 1.0 2.1 1.5 1.2 0.7 0.1
Leg fat-free mass (left) 0.3 1.5 4.3 -2.1 -0.7 0.1 -1.2
Trunk fat percentage 0.4 1.5 3.9 -1.3 0.1 0.8 -2.0
Hand grip strength (right) 0.3 0.8 2.5 0.3 -1.6 -0.2 -0.7
Townsend deprivation index at recruitment 0.8 1.2 2.7 -1.0 1.6 0.6 -0.8
Current tobacco smoking 0.9 1.5 4.9 -0.8 2.2 0.4 -0.7
Average weekly fortified wine intake 0.1 0.2 0.4 0.3 -0.1 0.6 0.4
Maternal smoking around birth 1.7 2.4 3.8 -0.8 1.2 1.9 -1.9
Fed-up feelings 0.2 0.4 1.5 0.3 1.2 -0.3 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.0 -0.3 -0.6 -1.0 0.5
Relative age voice broke 0.0 0.1 0.2 0.2 0.2 -0.4 -0.1
Taking other prescription medications 0.1 0.2 0.6 -0.4 -0.7 -0.1 0.4
Age when periods started (menarche) 0.4 1.0 2.9 -0.7 0.1 1.7 0.9
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.8 -0.2 -1.2 0.7 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 1.8 0.7 -1.3 -1.3 1.4
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.1 -1.5 1.0 1.0 -1.8
Qualifications: CSEs or equivalent 1.7 2.3 6.5 0.1 -2.5 -1.5 0.6
Serious illness, injury or assault to yourself 1.1 1.3 2.2 -1.1 -1.3 -0.4 1.5
High blood pressure 0.4 1.2 1.9 -1.4 1.2 1.0 -0.8
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.6 0.7 -0.7 -0.1 1.3
Multivitamins +/- minerals 0.8 1.0 1.7 -1.3 0.9 0.3 -1.2
Stomach or abdominal pain in last month 0.2 0.2 0.4 -0.6 0.1 0.6 0.3
Supplements: Glucosamine 0.3 0.4 0.7 -0.8 -0.6 -0.5 0.5
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.7 -0.9 0.5 1.7 -1.0
Medication: Atenolol 2.5 3.1 4.3 1.3 -1.9 -2.1 1.7
Medication: Levothyroxine sodium 0.2 0.4 0.8 -0.9 0.6 0.3 0.4
Sitting height 0.1 0.6 2.0 0.2 -0.4 1.4 -0.5
Chronic bronchitis/emphysema (father) 0.6 0.6 1.3 1.1 0.7 -0.5 -0.6
High blood pressure (mother) 0.3 0.4 1.2 0.3 -1.1 0.0 0.7
Body mass index (BMI) 0.5 2.0 4.3 -2.1 -0.2 -0.2 -1.9
Impedance of leg (left) 0.2 0.9 1.8 1.4 1.1 0.8 0.2
Leg predicted mass (left) 0.3 1.4 3.8 -2.0 -0.8 -0.0 -1.1
Trunk fat mass 0.7 2.8 5.8 -2.1 0.1 1.0 -2.4
Waist circumference 0.7 2.7 6.2 -2.5 0.6 1.1 -1.8
Number of incorrect matches in round 0.5 0.9 1.1 0.8 -1.0 -0.9 1.0
Past tobacco smoking 0.9 1.7 5.9 0.3 -2.4 -0.3 0.8
Alcohol usually taken with meals 0.6 1.0 3.3 0.7 -0.5 -0.0 1.8
Nervous feelings 3.2 5.9 8.4 2.9 -1.9 -2.9 1.9
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 2.0 -1.4 0.8 -0.2 -0.1
Hearing difficulty/problems with background noise 0.2 0.4 0.8 -0.9 -0.7 0.3 0.3
Hair/balding pattern: Pattern 2 0.6 0.7 1.7 0.5 -0.8 -0.5 1.3
Had menopause 0.6 0.7 1.9 0.2 -0.9 0.0 1.4
Had other major operations 1.8 2.2 3.9 -2.0 0.5 2.0 -0.9
Forced vital capacity (FVC) 0.1 0.5 1.0 -0.9 0.5 1.0 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.2 0.5 -1.0 -0.7 1.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.7 0.5 -0.0 -0.8 -0.4
Qualifications: None of the above 0.5 1.0 2.7 1.6 0.3 -0.6 -0.9
Financial difficulties in last 2 years 0.5 0.7 1.1 -0.5 -0.8 -0.8 1.1
Mouth/teeth dental problems 0.5 0.8 1.7 -0.3 1.3 1.1 -0.4
Heart attack 0.7 0.9 1.6 0.7 -1.1 -1.3 0.6
Allergy 0.3 0.7 2.2 -0.1 0.7 -0.3 -1.5
Pain all over the body in last month 0.9 1.0 2.1 0.3 0.2 -1.3 -1.5
Diabetes (self-reported) 0.3 0.5 1.5 -0.6 0.5 0.0 -1.2
Hayfever/allergic rhinitis (self-reported) 0.9 1.3 2.2 -0.9 1.4 1.5 -0.5
Medication: Ramipril 0.1 0.1 0.2 0.4 -0.2 -0.2 -0.1
Medication: Simvastatin 0.2 0.3 1.0 -1.0 -0.4 -0.0 -0.3
Fluid intelligence score 1.5 3.1 8.9 -3.0 0.8 1.6 -0.4
Illnesses of siblings 0.4 0.6 1.3 1.1 0.0 -0.5 0.9
Neuroticism score 0.6 1.3 3.9 1.0 0.0 -2.0 0.3
Weight 0.5 2.6 5.8 -2.4 -0.1 0.7 -2.0
Impedance of arm (right) 0.5 2.2 5.5 2.3 1.0 1.4 0.2
Arm fat percentage (right) 0.6 2.2 6.1 -1.6 0.0 0.5 -2.5
Trunk fat-free mass 0.3 1.5 4.4 -2.1 -0.8 -0.1 -1.0
Hip circumference 0.4 1.7 3.1 -1.8 -0.5 1.0 -1.7
Time employed in main current job 3.8 4.4 7.0 1.8 -2.6 -1.9 1.9
Alcohol intake versus 10 years previously 0.4 0.7 2.0 0.5 -0.3 -1.4 -0.5
Father’s age at death 0.2 0.2 0.5 -0.2 0.7 0.0 -0.6
Worrier / anxious feelings 1.5 2.8 4.9 1.7 -1.2 -2.2 1.4
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.4 -0.4 -0.8 -1.5 0.3
Falls in the last year 0.6 0.8 1.5 0.2 -1.1 -1.2 0.6
Hair/balding pattern: Pattern 3 0.4 0.6 1.6 -1.2 -0.0 -0.9 -0.1
Number of live births 1.1 1.6 3.3 -1.5 0.5 1.8 0.5
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.7 -1.3 0.5 0.9 -0.6
Pulse rate 1.6 2.8 4.9 0.5 -2.2 -1.9 1.5
Happiness 0.4 0.5 1.6 1.3 0.6 -0.2 -0.4
Noisy workplace 0.9 1.2 3.4 1.0 -0.4 -1.8 0.3
Qualifications: A levels/AS levels or equivalent 1.4 3.1 6.4 -2.5 1.2 2.1 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.6 -0.8 -0.5 0.5 0.3
Mouth/teeth dental problems: Dentures 0.1 0.2 0.4 0.0 -0.5 -0.1 -0.6
Asthma 0.2 0.5 0.9 -0.6 -0.6 0.5 0.9
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.5 2.7 1.2 -0.9 -0.9 1.6
Medication: Cholesterol lowering 2.0 3.2 6.4 -0.6 -2.4 -2.5 0.4
Depression (self-reported) 0.8 0.9 2.7 0.3 1.6 0.7 -0.7
Medication: Lansoprazole 0.2 0.2 0.6 0.2 -0.1 -0.8 -0.3
Prospective memory result 3.2 4.0 5.0 2.0 -2.2 -2.2 1.5
Lung cancer (father) 0.7 0.9 2.3 -1.5 1.0 0.3 0.1
Illnesses of mother 1.3 1.6 2.9 -0.9 1.4 0.8 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.7 -1.3 0.2 0.8 -0.5
Pulse wave Arterial Stiffness index 0.5 0.5 1.0 0.6 -0.6 -1.0 0.6
Impedance of arm (left) 0.4 1.8 4.0 2.0 1.1 1.4 0.4
Arm fat mass (right) 0.6 2.3 5.2 -1.9 -0.2 0.6 -2.3
Trunk predicted mass 0.3 1.5 4.4 -2.1 -0.8 -0.2 -0.9
Standing height 0.1 0.9 2.9 -0.7 -0.0 1.7 -0.6
Length of working week for main job 3.8 4.2 7.3 -1.7 1.5 2.2 -2.7
Exposure to tobacco smoke at home 0.7 0.8 2.0 -0.5 1.4 0.9 -0.4
Breastfed as a baby 2.4 2.9 8.2 0.7 -2.9 -1.1 1.3
Tense / ‘highly strung’ 0.4 0.7 1.3 1.1 1.0 -0.6 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 3.4 -0.4 1.9 -0.0 -0.5
Hair/balding pattern: Pattern 4 1.0 2.5 4.8 1.6 -1.5 -2.2 0.6
Birth weight of first child 0.2 0.3 0.6 0.7 -0.3 0.7 0.4
Peak expiratory flow (PEF) 0.2 0.4 1.1 -0.2 -0.1 1.0 -0.7
Pulse wave reflection index 0.8 1.0 2.1 1.4 1.3 -0.1 -0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.0 -0.2 1.0 0.5 -1.4
Loud music exposure frequency 0.1 0.1 0.2 -0.1 -0.2 -0.4 0.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.5 -1.9 -0.5 0.5 1.6
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 -0.3 -0.7 -1.1 0.3
Blood clot in the leg (DVT) 1.9 2.4 3.2 -1.1 1.8 1.7 -1.5
Medication: Paracetamol 0.3 0.5 0.9 0.7 0.9 0.3 -0.7
Headache pain in last month 0.7 1.2 2.2 0.9 -1.5 -0.3 1.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.5 0.5 1.2 1.1 0.0
Glaucoma (self-reported) 0.6 0.7 1.4 0.0 1.2 0.8 -0.8
Gout (self-reported) 0.8 1.0 1.6 -1.3 0.8 1.1 -0.8
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.4 -0.4 -0.3 0.0 0.6
Medication: Amlodipine 1.3 1.8 3.4 -1.7 1.8 0.9 -0.4
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.0 -0.4 1.0 1.0 -0.6
Birth weight 0.6 1.4 5.3 -2.3 -0.1 -0.6 -0.1
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.8 0.1 -0.2 -0.2 -0.9
High blood pressure (siblings) 0.1 0.2 0.4 -0.1 -0.3 0.6 0.4
Forced vital capacity (FVC), Best measure 0.1 0.2 0.4 -0.6 0.1 0.7 0.2
Body fat percentage 0.5 2.0 5.0 -1.6 0.2 0.6 -2.2
Leg fat percentage (right) 0.8 2.9 6.8 -2.1 0.4 0.1 -2.6
Arm fat-free mass (right) 0.3 1.6 4.7 -2.2 -1.1 -0.4 -0.7
Exposure to tobacco smoke outside home 0.4 0.6 2.0 -1.4 0.4 -0.2 -0.1
Comparative body size at age 10 0.3 0.9 3.6 -1.9 0.3 0.3 -0.0
Number of full brothers 0.4 0.5 0.7 -0.8 0.6 0.8 -0.7
Worry too long after embarrassment 2.1 3.5 6.5 1.1 -2.2 -2.5 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.4 0.3 1.2 0.5 -0.8
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 0.6 0.5 -0.3 -0.1
Number of children fathered 2.1 2.4 3.3 -1.8 1.4 1.1 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.8 2.8 1.7 -1.6 -1.4 0.4
Age at first live birth 0.4 0.7 2.4 0.5 0.5 1.6 0.1
Pulse wave peak to peak time 1.0 1.2 2.2 -1.1 0.9 1.5 -0.8
Health satisfaction 0.5 0.6 1.3 -0.4 -1.0 -1.1 0.2
Shortness of breath walking on level ground 0.1 0.1 0.2 0.3 0.2 -0.4 -0.3
Qualifications: College or University degree 2.7 8.5 15.6 -2.8 2.5 3.9 -2.0
Eye problems/disorders: None of the above 0.8 1.0 2.1 -0.2 -1.1 -0.7 1.4
Mouth/teeth dental problems: Loose teeth 0.9 1.0 3.1 -0.7 1.8 -0.7 0.4
Emphysema/chronic bronchitis 1.0 1.1 1.8 -0.2 -1.3 -1.1 1.3
Medication for pain relief, constipation, heartburn 0.5 0.9 1.8 -1.2 0.6 1.3 -0.4
Neck or shoulder pain in last month 0.2 0.3 0.6 -0.7 -0.8 -0.1 0.6
Medication: Blood pressure 0.1 0.2 0.5 -0.7 0.1 0.4 -0.1
Angina (self-reported) 0.9 1.2 3.2 0.3 -1.2 -1.8 0.2
Migraine (self-reported) 0.2 0.2 0.7 -0.8 0.2 0.3 -0.3
Medication: Ibuprofen 0.8 1.0 1.9 1.3 -0.2 -0.6 1.4
Medication: Allopurinol 0.3 0.4 1.0 -0.7 0.2 0.5 -1.0
Medication: Omeprazole 0.3 0.3 0.8 0.1 -0.7 -0.9 -0.1
Medication: Seretide 50 evohaler 0.9 1.0 2.1 -1.4 -0.9 1.0 0.0
Mean time to correctly identify matches 0.8 1.5 3.0 0.4 -1.2 -1.2 1.7
Heart disease (mother) 0.3 0.3 1.0 0.4 0.3 -0.2 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.5 -1.2 0.1 0.5 1.0
Whole body fat mass 0.5 2.2 4.9 -2.0 -0.2 0.5 -2.2
Leg fat mass (right) 0.8 3.1 6.4 -2.5 -0.1 0.1 -2.4
Arm predicted mass (right) 0.3 1.8 5.5 -2.4 -0.8 -0.1 -0.9
Pulse rate, automated reading 1.8 5.7 10.0 1.0 -2.5 -3.2 2.3
Alcohol intake frequency. 0.1 0.3 1.2 -0.1 1.1 -0.0 0.4
Comparative height size at age 10 0.1 0.3 0.9 -0.9 -0.6 0.4 0.1
Number of full sisters 0.7 0.9 1.6 -1.1 -0.8 -0.1 1.3
Suffer from ‘nerves’ 0.7 1.0 1.8 0.9 -1.1 -1.4 0.5
Overall health rating 0.4 0.9 2.4 -0.9 -0.3 -1.6 0.4
Chest pain or discomfort 0.5 0.8 2.8 -1.7 -0.4 -0.5 -0.1
Had major operations 0.1 0.1 0.5 -0.7 0.0 0.2 0.2
Age at last live birth 0.4 0.5 1.0 0.6 -0.0 0.9 1.0
Family relationship satisfaction 0.2 0.2 0.4 -0.6 -0.3 0.2 0.6
Leg pain on walking 0.4 0.5 1.1 -0.3 1.1 0.1 -1.0
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.4 0.9 -1.0 -1.6 0.7
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.2 -0.7 -0.2 0.6 -1.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.1 1.8 0.8 -0.6 -0.2
Medication: Aspirin 0.6 0.8 1.7 -1.3 -0.3 0.1 -1.2
Supplements: Vitamin C 0.5 0.6 2.2 1.5 0.0 -0.4 0.4
Knee pain experienced in last month 1.1 1.7 4.6 -2.1 0.3 1.4 -0.1
Hypertension (Self-reported) 0.5 1.4 1.7 -1.2 1.3 1.3 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 2.1 -1.3 1.5 0.9 -1.1
Illnesses of father: Heart disease 1.5 2.1 4.0 0.7 -2.0 -2.0 0.2
Illnesses of siblings: Diabetes 0.3 0.4 1.4 1.2 0.1 -0.5 0.0
Smoking status: Previous 0.2 0.3 1.2 0.1 1.1 -0.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.7 0.0 -0.1 0.6 -0.8
Whole body fat-free mass 0.3 1.7 4.9 -2.2 -0.7 0.0 -1.1
Leg fat-free mass (right) 0.2 1.3 3.5 -1.9 -0.8 0.1 -1.0
Arm fat percentage (left) 0.5 2.1 5.1 -1.8 0.0 0.4 -2.2
Average weekly red wine intake 0.7 1.1 3.2 -0.7 0.5 1.8 -0.8
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.4 -0.3 1.2 0.5 -0.8
Mood swings 0.5 0.9 2.2 0.3 1.5 -0.9 -0.8
Loneliness, isolation 1.0 1.3 3.4 -0.7 1.8 0.5 -1.1
Long-standing illness, disability or infirmity 0.4 0.6 1.0 -0.3 -0.7 -0.8 1.0
Ever had bowel cancer screening 0.5 0.5 1.7 -0.3 -0.4 0.4 1.3
Diabetes diagnosed by doctor 0.3 0.6 2.0 -0.1 0.3 -0.2 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.5 -0.2 -0.7 0.1 0.1
Friendships satisfaction 0.4 0.5 1.4 -1.2 0.0 0.6 0.7
Qualifications: nursing, teaching 0.1 0.2 0.5 -0.7 -0.5 0.3 -0.1
Commuting to job workplace: Walk 0.7 0.7 1.2 -0.4 1.1 0.9 -0.8
Eye problems/disorders: Cataract 3.4 3.9 5.9 -1.5 2.0 1.9 -2.4
Mouth/teeth dental problems: Mouth ulcers 1.7 2.8 4.0 2.0 -1.6 -1.2 1.8
Medication for cholesterol 1.4 2.2 5.5 1.3 -1.0 -2.3 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.9 0.0 -0.9 0.0 0.1
Back pain experienced in last month 0.3 0.4 0.7 -0.8 -0.9 -0.5 0.4
Mineral and other dietary supplements 0.1 0.1 0.3 0.1 0.6 0.4 0.1
Breast cancer (self-reported) 2.3 2.7 3.5 1.9 -1.0 -1.7 1.9
Asthma (self-reported) 0.2 0.3 0.7 -0.5 -0.4 0.5 0.8
Osteoporosis (self-reported) 0.9 1.1 1.8 -1.3 0.6 0.9 -1.2
Osteoarthritis (self-reported) 0.4 0.5 1.0 -0.6 0.3 -1.0 0.8
Medication: Aspirin 0.5 0.7 1.6 -1.1 -0.2 -0.2 -1.3
Medication: Gliclazide 0.2 0.2 0.6 0.5 0.1 0.2 -0.8
Illnesses of father: None of the above (group 1) 0.4 0.5 0.7 0.7 0.4 0.6 0.8
Smoking status: Current 1.5 2.4 6.9 -1.1 2.6 0.7 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.3 0.4 -0.6 0.2 0.6
Whole body water mass 0.3 1.5 4.3 -2.1 -0.9 -0.1 -0.9
Leg predicted mass (right) 0.2 1.3 3.7 -1.9 -0.8 0.1 -1.0
Arm fat mass (left) 0.5 2.2 4.6 -2.0 -0.1 0.4 -2.1
Number of self-reported non-cancer illnesses 1.1 1.9 4.9 -2.2 1.0 1.2 -0.7
Average weekly champagne plus white wine intake 0.3 0.4 0.6 -0.8 0.7 -0.0 0.6
Miserableness 0.3 0.6 1.1 0.9 0.4 -1.1 0.4
Guilty feelings 0.6 0.9 2.6 0.6 -0.5 -1.6 0.6
Wears glasses or contact lenses 0.8 0.9 2.9 -0.5 -1.7 0.2 0.8
Ever taken oral contraceptive pill 0.2 0.2 0.5 0.0 -0.5 0.3 -0.7
Hearing aid user 0.8 0.9 2.2 1.1 -0.1 -1.5 0.5
Mother’s age at death 0.3 0.4 1.1 1.1 -0.4 -0.4 0.1
Financial situation satisfaction 0.3 0.4 1.3 -0.0 -1.1 -0.0 -0.4
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.8 0.9 0.4 -0.2 0.3
Commuting to job workplace: Public transport 0.7 0.9 1.1 -1.0 0.8 0.9 1.1
Eye problems/disorders: Glaucoma 1.5 1.8 2.6 -0.6 1.5 1.6 -1.3
Medication: Blood pressure 0.7 1.3 2.5 0.3 1.6 1.1 -1.1
Pain type(s) experienced in last month: Hip pain 0.9 1.1 4.1 -2.0 -0.1 0.5 0.3
Supplements: Fish oil (including cod liver oil) 1.9 2.5 5.6 0.6 -2.4 -1.6 1.3
High cholesterol (Self-reported) 0.6 1.1 2.2 -0.6 -1.5 -1.3 -0.2
Medication: Bendroflumethiazide 0.7 1.1 2.5 -0.3 1.2 1.6 -0.7
Medication: Paracetamol 0.3 0.4 0.7 0.9 0.8 0.3 -0.3
Medication: Lisinopril 1.2 1.5 2.3 -1.0 1.5 1.2 -1.2
Medication: Atorvastatin 2.0 2.5 4.6 0.5 -2.1 -2.1 0.9
Illnesses of father: High blood pressure 1.3 1.6 3.3 -1.8 0.8 1.1 -1.2
Alcohol drinker status: Never 0.5 0.6 1.3 -1.1 -0.1 1.1 0.3
Ever smoked 0.7 1.2 4.3 0.1 2.1 -0.4 -0.4
Basal metabolic rate 0.3 1.9 5.2 -2.3 -0.7 0.1 -1.3
Leg fat percentage (left) 1.0 3.7 8.2 -2.4 0.6 0.5 -2.9
Arm fat-free mass (left) 0.3 1.6 4.6 -2.1 -0.8 -0.2 -1.0
Number of operations (self-reported) 0.7 1.1 2.3 -1.5 0.2 1.3 -0.4
Average weekly beer plus cider intake 1.2 1.7 4.9 -2.2 0.8 0.6 -1.0
Irritability 1.6 2.7 6.0 -0.7 2.4 1.7 -1.1
Risk taking 0.2 0.2 0.7 0.1 -0.2 0.8 0.4
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.2 -1.5 1.0 0.9 -0.8
Fractured/broken bones in last 5 years 1.7 2.1 6.2 -2.5 0.3 1.5 -0.1
Age started oral contraceptive pill 1.3 1.7 4.3 0.3 1.5 2.1 -0.4
Diastolic blood pressure, automated reading 0.2 0.7 1.9 -1.4 -0.8 -0.1 0.4
Ever depressed for a whole week 0.8 1.0 1.7 0.9 -1.0 -1.3 0.8
Unable to work because of sickness or disability 0.3 0.4 1.4 -0.2 0.5 -1.2 -0.3
Commuting to job workplace: Cycle 0.2 0.2 0.3 0.5 0.6 0.5 0.1
Myopia 0.3 0.4 0.7 -0.8 0.8 0.7 0.1
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.3 1.5 -0.8 -0.3 0.8
Cholesterol lowering medication 0.4 0.5 1.3 -1.2 -0.1 0.9 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.7 0.2 -0.1 -0.8 0.4
Pain experienced in last month 0.1 0.2 0.5 0.5 0.1 0.7 0.3
Supplements: Calcium 0.1 0.1 0.4 0.3 0.1 0.3 -0.6
Basal cell carcinoma (self-reported) 0.5 0.6 1.1 -1.0 -0.3 0.8 0.8
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.9 0.3 -1.0 -0.9 0.4
Deep venous thrombosis (DVT) (self-reported) 2.4 3.0 3.9 -1.3 1.9 2.0 -1.7
Heart disease (siblings) 0.4 0.5 1.7 -1.3 0.3 0.2 -0.3
Alcohol drinker status: Previous 0.5 0.6 2.0 -0.3 -0.2 -0.4 1.4
Pack years of smoking 0.3 0.5 1.1 0.7 0.6 -1.1 -0.1
Impedance of whole body 0.3 1.6 3.3 1.8 1.2 1.3 0.3
Leg fat mass (left) 0.9 3.3 6.9 -2.6 -0.0 0.4 -2.5
Arm predicted mass (left) 0.4 1.8 4.8 -2.2 -0.9 -0.1 -1.3