Hub : Genes

Y_RNA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.150 0.0500 1.2e-03 0.079 NA 0.008 NA 0.048 8.7e-07 NA 6.6e-02 NA 1.1e-04
2 GTEx Breast Mammary Tissue (Male) 0.234 0.1228 2.5e-02 -0.010 NA -0.013 NA -0.008 6.6e-01 NA 8.6e-01 NA 5.6e-01
3 GTEx Colon Sigmoid 0.361 0.0790 1.1e-05 0.067 NA 0.227 NA 0.179 2.2e-03 NA 1.5e-08 NA 6.4e-07
4 GTEx Esophagus Mucosa 0.189 0.0610 9.5e-04 0.064 NA 0.126 NA 0.122 4.4e-05 NA 9.7e-09 NA 1.6e-08
5 GTEx Muscle Skeletal 0.113 0.0346 3.0e-04 0.031 NA 0.061 NA 0.047 4.2e-04 NA 1.3e-06 NA 2.2e-05
6 GTEx Nerve Tibial 0.197 0.0565 1.7e-04 0.155 NA 0.077 NA 0.141 4.4e-11 NA 4.2e-06 NA 3.3e-10
7 GTEx Thyroid 0.175 0.0710 5.4e-04 0.038 NA 0.062 NA 0.078 6.3e-04 NA 1.5e-05 NA 1.4e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.7 2.2 0.0 -0.1 1.1 -0.0 0.1 -1.1 -1.5
Bipolar Disorder or Schizophrenia 0.7 1.7 4.8 -0.4 -1.4 -0.6 -2.1 -0.2 -0.5 -2.2
Depressed Affect (Nagel 2018) 0.2 0.4 1.4 -0.7 -0.3 0.7 0.3 -0.5 -0.5 -1.2
Depression (Nagel 2018) 0.4 0.5 1.2 -1.0 -0.2 0.2 0.6 -0.8 0.8 -1.1
Intelligence (Savage-Jansen 2018) 1.7 5.1 8.1 -1.8 -2.6 -2.7 -2.8 -1.9 2.1 1.7
Neuroticism (Nagel 2018) 0.3 0.7 2.4 0.6 0.7 1.5 0.5 0.7 -0.6 -0.9
Schizophrenia (2018) 1.1 2.3 7.1 -0.6 -1.7 -1.6 -2.7 -0.4 0.3 -1.6
Schizophrenia vs Biploar Disorder 1.0 1.3 4.8 -0.5 -1.7 -2.2 -0.5 -0.4 -0.9 0.6
Worry (Nagel 2018) 0.4 0.9 1.8 0.4 0.8 1.3 0.4 0.7 -1.2 -1.3
Alzheimer’s Disease (in mother) 0.8 1.0 4.4 0.3 2.1 0.7 1.2 0.4 -0.4 -0.1
Alzheimer’s Disease (in father) 1.0 1.1 3.1 1.2 0.7 -0.9 0.6 1.2 1.8 0.4
Alzheimer’s Disease (including proxy) 0.7 1.0 2.7 0.7 1.6 0.6 1.6 0.7 0.9 0.0
Crohns Disease (2017) 0.4 0.8 3.7 0.0 -0.8 0.2 -0.8 0.3 -0.7 -1.9
Irritable Bowel Disease (IBD) 0.5 1.2 3.6 0.8 -0.3 -0.9 -1.2 1.1 -0.5 -1.9
Ulcerative Colitis (UC) 0.8 1.5 3.4 0.5 -0.5 -1.6 -1.9 0.7 0.1 -1.8
Major Depression (MDD) 1.2 1.5 4.1 -0.7 1.2 -1.8 -0.0 -0.5 1.0 -2.0
Reaction Time 0.3 0.6 3.4 0.1 0.8 -0.3 0.1 0.0 0.3 1.8
Verbal and Numeric Reasoning (VNR) 1.4 3.3 9.3 -1.0 -1.2 -2.7 -1.7 -1.0 3.1 0.7
Breast Cancer 0.8 1.9 5.7 -0.7 -2.4 0.3 -1.7 -0.9 1.6 1.0
Ovarian Cancer 2.5 3.3 11.5 -1.5 -3.4 -0.6 -2.3 -1.6 -0.2 -0.9
Prostate Cancer 0.8 1.2 3.5 0.6 1.9 0.3 0.6 0.4 -1.1 1.5
Age at First Birth 1.0 1.5 5.2 -0.0 -1.0 -0.6 -2.3 -0.1 -0.5 1.9
Bipolar Disorder (2011) 0.5 0.5 1.8 0.3 0.8 1.3 -0.3 0.5 -0.8 0.0
Body Mass Index (BMI) (2010) 2.1 2.8 5.9 1.6 1.6 1.2 2.4 1.7 -0.5 2.0
Coronary Artery Disease (CAD) 0.2 0.3 0.9 -0.3 0.4 0.9 -0.3 -0.2 0.3 -0.7
Crohns Disease (2012) 0.3 0.4 1.2 0.6 -0.1 0.1 -1.1 0.8 -0.1 -0.8
Mean Putamen Volume 0.7 0.8 2.2 -1.0 -0.9 1.5 0.7 -0.7 -0.0 0.7
Fasting Glucose 0.7 0.9 4.3 -0.1 1.0 0.6 -0.2 -0.0 -2.1 0.5
HbA1C 0.3 0.3 1.4 -0.2 0.6 1.2 0.2 -0.3 0.4 0.4
HDL Cholesterol 0.5 0.9 3.0 -0.0 -0.5 0.8 -0.4 -0.2 -1.4 1.7
LDL Cholesterol 0.6 1.0 1.8 1.3 1.0 0.6 1.2 1.4 -0.4 -0.3
Lupus 0.6 0.9 3.1 -0.5 -1.8 -1.0 -1.4 -0.4 0.3 0.2
Neuroticism (2016) 0.9 1.3 4.5 -0.5 -1.2 2.1 -1.0 -0.5 -0.1 -1.2
Primary Biliary Cirrhosis 1.2 1.6 3.4 1.4 0.3 1.7 1.1 1.3 1.8 -0.3
Rheumatoid Arthritis 0.6 0.8 2.1 0.2 1.5 0.2 1.3 0.3 -0.2 1.3
Schizophrenia (2014) 0.9 1.9 5.4 -0.7 -1.6 -1.8 -2.3 -0.6 -0.0 -1.1
Triglycerides 0.7 1.2 5.1 0.7 -0.3 -0.6 -1.3 0.8 0.2 -2.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.9 0.1 0.1 -0.2 -0.9 0.1 1.1 1.7
Ulcerative Colitis 0.5 0.8 2.6 1.5 0.7 0.1 -0.4 1.6 -0.1 0.1
Blood Eosinophil Count 0.4 3.1 15.0 -0.6 -0.6 -1.3 -2.0 -0.7 0.0 3.9
Blood Platelet Count 0.1 0.9 1.9 -0.6 -1.2 1.1 -0.4 -0.8 0.8 -1.4
Blood Red Count 0.2 2.4 9.1 1.3 0.4 0.2 0.4 1.1 -2.1 -3.0
Blood White Count 0.1 0.9 4.3 0.8 -0.7 -0.3 -0.6 0.8 -2.1 -0.1
Heel T-Score 0.6 5.1 15.7 1.6 0.9 1.6 0.6 1.4 -4.0 -3.4
BMI 0.3 1.6 4.7 0.0 2.2 1.3 1.7 0.2 1.1 1.0
Height 0.2 3.4 14.6 1.4 -1.8 1.3 0.6 0.9 -3.8 1.1
Waist Hip Ratio (WHR) 1.6 7.3 16.5 2.0 3.5 -3.2 0.7 2.3 -4.1 -1.5
Systolic Blood Pressure 0.1 0.7 1.7 1.1 0.6 -0.7 1.3 1.1 0.0 -0.5
Smoking Status 0.3 0.8 3.1 -0.3 0.6 -1.2 1.8 0.4 -0.0 -0.8
Allergy or Eczema 0.4 1.0 3.0 -0.2 -0.0 1.6 0.2 -0.5 -1.1 1.7
Cardiovascular Disease 1.1 3.5 9.2 1.9 2.4 -0.2 3.0 2.2 -1.1 0.3
Hypothyroidism (self reported) 0.4 0.9 3.4 -0.8 -1.1 0.1 -0.6 -0.7 1.9 -0.7
Respiratory disease 0.6 1.3 8.6 -0.4 -0.2 0.1 -0.3 -0.4 0.4 2.9
Type 2 Diabetes (T2D) (2018) 0.9 1.7 4.2 1.2 1.2 1.3 0.1 1.5 0.9 -2.0
Lung FEV1/FVC ratio 0.0 0.2 0.6 0.2 0.1 0.8 -0.0 0.3 0.8 -0.3
Lung FVC 0.5 2.8 6.5 1.9 -0.6 2.3 1.3 1.5 2.5 0.2
Neuroticism 0.5 1.1 4.5 -0.2 0.1 2.1 0.6 -0.0 -1.6 -0.5
Chronotype (morning person) 0.5 1.1 2.0 1.2 -0.7 1.2 0.5 0.8 1.4 1.1
Hair Pigment 0.0 1.4 7.3 0.3 -0.5 0.4 -1.4 0.2 -2.7 -0.0
Tanning 0.2 1.9 11.2 -1.3 -0.1 0.2 -0.1 -0.8 3.3 0.4
Hand grip strength (left) 0.3 0.9 2.7 0.1 -1.5 -0.9 0.3 -0.1 -1.7 0.7
Number of treatments/medications taken 0.5 0.8 2.6 -1.3 0.4 0.2 0.0 -1.2 -0.0 -1.6
Average weekly spirits intake 0.4 0.5 2.2 0.7 0.4 1.5 0.3 0.7 0.2 0.0
Sensitivity / hurt feelings 1.9 3.2 7.0 2.6 2.4 0.9 1.1 2.6 0.3 -1.1
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.8 -1.2 -0.8 -0.1 0.0 -1.4 0.9 -0.4
Hearing difficulty/problems: Yes 2.1 3.2 18.1 0.1 4.2 -0.7 1.0 0.0 -1.6 -0.6
Relative age of first facial hair 0.9 1.8 4.2 0.8 -0.6 1.6 -0.2 1.0 -1.9 -2.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.2 -0.1 1.5 0.3 1.0 0.0 1.5 -0.5
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.8 -0.9 0.1 0.3 -0.2 -0.6 0.1 0.6
Ever had hysterectomy (womb removed) 0.5 0.6 1.8 0.1 1.3 0.9 1.3 0.1 -0.1 -0.1
Systolic blood pressure, automated reading 0.2 0.7 3.2 0.1 -0.4 -1.0 -0.1 0.1 1.8 -0.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 0.9 -1.0 -0.6 -0.6 -0.1 -0.8 -0.9 -0.8
Angina 0.6 0.8 5.1 -0.4 0.4 -0.1 0.1 -0.0 -0.6 -2.3
Medication for hormone replacement therapy 2.7 3.0 6.4 -1.9 -2.0 -1.1 -1.4 -2.0 0.1 2.5
Vitamin and mineral supplements 1.1 1.4 3.0 -0.8 -1.7 -1.2 -1.1 -1.0 -0.0 -1.7
Supplements: Zinc 1.8 1.9 3.5 -1.9 -1.5 -0.7 -1.0 -1.8 -0.7 1.5
Medication: Co-codamol 0.5 0.5 0.8 -0.8 0.4 -0.6 -0.8 -0.7 0.8 -0.9
Medication: Metformin 0.6 0.9 4.1 0.7 0.0 0.1 -0.4 0.9 2.0 -0.8
Diabetes (father) 1.1 1.3 2.0 -1.3 -1.4 1.2 -0.8 -1.4 1.3 0.3
Diabetes (mother) 0.7 0.9 2.4 -1.0 -0.8 -1.6 -1.0 -0.8 0.7 -0.5
Severe depression (siblings) 0.7 0.8 1.6 0.8 0.6 1.1 1.3 0.7 0.3 1.1
Pack years adult smoking proportion 0.3 0.5 0.8 0.7 -0.9 -0.5 -0.9 0.9 0.0 -0.8
Impedance of leg (right) 0.2 1.1 2.7 0.8 -0.7 -0.8 -0.9 0.5 -1.5 -1.6
Leg fat-free mass (left) 0.3 1.8 6.2 0.1 0.2 1.2 1.9 0.1 -1.1 2.5
Trunk fat percentage 0.4 1.7 4.0 -0.4 1.2 2.0 1.8 -0.4 -1.7 -0.4
Hand grip strength (right) 0.4 1.2 4.9 0.6 -0.8 -1.1 0.3 0.6 -2.2 0.9
Townsend deprivation index at recruitment 0.6 0.9 3.1 -0.8 -0.0 0.6 -0.0 -0.5 -1.3 -1.8
Current tobacco smoking 0.6 1.0 3.7 -0.3 1.0 -1.4 1.9 0.1 -0.2 -0.6
Average weekly fortified wine intake 0.2 0.3 0.8 0.1 0.8 -0.2 0.5 0.2 -0.1 0.9
Maternal smoking around birth 1.0 1.4 3.4 -0.4 1.1 -1.4 0.7 -0.0 -1.9 -1.7
Fed-up feelings 0.2 0.4 1.4 -0.4 -0.5 0.7 0.5 -0.4 0.3 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 4.0 -2.0 -0.7 0.2 -0.2 -1.8 0.2 -1.8
Relative age voice broke 0.7 1.1 1.7 1.0 1.3 1.0 -0.0 1.1 0.9 -1.3
Taking other prescription medications 0.1 0.2 0.5 0.3 0.7 -0.4 -0.4 0.3 -0.5 -0.2
Age when periods started (menarche) 0.7 1.7 5.0 0.8 0.4 -2.2 -1.4 0.5 -0.6 -1.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.9 -0.1 -0.0 1.4 -0.6 -0.1 0.3 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 11.3 2.1 1.2 0.7 0.7 1.8 -3.4 -1.3
Tinnitus: Yes, but not now, but have in the past 1.9 2.1 4.6 2.1 0.2 1.5 1.5 1.9 0.5 -1.1
Qualifications: CSEs or equivalent 0.6 0.8 2.8 -0.7 1.7 1.1 1.0 -0.6 -0.5 0.1
Serious illness, injury or assault to yourself 0.4 0.5 1.4 -0.6 -0.8 0.6 0.6 -0.6 -1.2 0.1
High blood pressure 0.3 0.9 3.1 0.4 1.8 0.1 0.8 0.6 -0.0 -1.5
Hayfever, allergic rhinitis or eczema 0.6 1.3 7.1 -0.4 -0.8 0.2 -0.6 -0.9 -0.1 2.7
Multivitamins +/- minerals 1.1 1.4 4.5 0.2 2.1 0.3 0.9 0.4 -0.1 2.1
Stomach or abdominal pain in last month 0.7 0.9 2.6 -1.3 0.7 -1.0 -0.0 -1.6 -0.7 -0.0
Supplements: Glucosamine 0.6 0.8 1.9 1.0 0.0 1.3 0.0 0.9 1.4 -0.4
Diverticular disease/diverticulitis (self-reported) 2.7 3.3 7.6 1.7 1.8 2.8 2.2 1.8 0.0 -1.0
Medication: Atenolol 1.9 2.3 4.0 1.6 2.0 0.4 1.9 1.9 -0.5 -1.4
Medication: Levothyroxine sodium 0.3 0.5 1.0 -0.4 -0.9 -0.3 -1.0 -0.4 0.8 -1.0
Sitting height 0.4 2.8 10.3 0.9 -2.1 1.8 0.2 0.6 -0.7 3.2
Chronic bronchitis/emphysema (father) 1.0 1.2 5.8 -0.4 0.8 -0.2 0.2 0.0 1.4 -2.4
High blood pressure (mother) 1.3 1.8 3.1 -1.8 -1.6 -0.3 -1.4 -1.6 -0.1 1.5
Body mass index (BMI) 0.3 1.4 3.7 -0.4 1.8 1.6 1.9 -0.2 0.6 0.2
Impedance of leg (left) 0.2 1.0 2.7 0.3 -0.8 -0.8 -0.9 0.0 -1.5 -1.6
Leg predicted mass (left) 0.3 1.8 6.0 0.1 0.2 1.4 1.9 0.1 -1.0 2.5
Trunk fat mass 0.4 1.8 4.3 -0.2 1.0 1.9 2.1 -0.2 -1.8 0.2
Waist circumference 0.5 1.8 5.4 -0.2 2.3 0.4 1.8 0.1 -1.8 -0.6
Number of incorrect matches in round 0.3 0.5 1.1 -0.2 0.2 0.9 -1.0 -0.4 0.6 -0.9
Past tobacco smoking 0.5 0.9 3.0 0.5 -0.6 -0.4 -1.7 -0.0 1.2 0.9
Alcohol usually taken with meals 2.1 3.5 7.3 -1.0 -2.3 -1.7 -2.5 -0.9 0.8 2.7
Nervous feelings 0.3 0.6 1.1 1.0 0.1 1.1 -0.4 1.1 0.8 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.6 -0.8 1.4 -0.4 1.0 -1.0 -1.6 -0.4
Hearing difficulty/problems with background noise 1.7 2.7 15.3 1.2 3.9 0.2 1.1 1.1 0.1 0.3
Hair/balding pattern: Pattern 2 1.6 2.0 5.1 -1.4 -1.7 -0.9 -2.3 -1.4 -1.0 0.6
Had menopause 0.2 0.3 0.4 0.5 -0.6 0.6 0.3 0.6 0.6 -0.5
Had other major operations 0.5 0.7 3.8 -0.3 0.1 -0.4 -0.3 -0.3 -0.6 -2.0
Forced vital capacity (FVC) 0.3 1.1 2.9 1.1 -1.7 1.1 0.7 0.8 -0.8 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 9.8 1.1 0.5 0.4 0.2 0.8 -3.1 -1.3
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.8 -0.5 0.7 0.4 -0.4 -0.4 -0.9 0.1
Qualifications: None of the above 1.4 3.0 12.7 0.9 1.7 0.8 1.6 1.0 -0.4 -3.6
Financial difficulties in last 2 years 0.7 1.0 2.7 -0.3 1.2 1.5 1.6 -0.4 0.4 0.1
Mouth/teeth dental problems 1.0 1.5 4.3 -0.9 -1.7 -0.5 -0.9 -1.0 -0.8 2.1
Heart attack 1.8 2.4 12.4 -0.4 0.4 -1.0 1.1 -0.2 -1.3 -3.5
Allergy 0.7 1.6 9.0 0.6 0.7 -0.6 0.7 0.9 -0.1 -3.0
Pain all over the body in last month 2.3 2.4 6.9 -1.8 0.0 0.2 -0.6 -2.0 1.6 -2.6
Diabetes (self-reported) 0.9 1.4 3.8 1.0 1.2 1.1 0.0 1.2 1.1 -2.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.7 0.2 -0.3 0.9 -0.3 0.1 1.6 1.4
Medication: Ramipril 1.3 1.6 2.5 1.2 1.2 1.4 1.2 1.6 -0.8 -1.5
Medication: Simvastatin 0.3 0.4 1.2 0.4 0.6 0.4 0.7 0.4 0.0 -1.1
Fluid intelligence score 0.6 1.2 2.3 -1.1 -0.7 -1.1 -1.0 -1.0 1.5 1.2
Illnesses of siblings 0.2 0.3 0.6 -0.8 -0.6 -0.1 -0.1 -0.6 0.3 0.6
Neuroticism score 0.3 0.7 2.2 -0.2 0.1 1.5 -0.3 -0.2 -0.8 -1.4
Weight 0.3 1.4 3.7 -0.1 0.5 1.8 1.9 -0.1 -1.1 1.3
Impedance of arm (right) 0.5 2.4 13.7 0.2 -0.6 0.2 -1.2 -0.1 -3.7 -1.0
Arm fat percentage (right) 0.4 1.4 3.1 -0.1 1.6 1.7 1.7 -0.0 -1.2 -0.2
Trunk fat-free mass 0.3 1.7 8.5 0.4 -0.9 0.4 1.2 0.3 -0.9 2.9
Hip circumference 0.6 2.6 8.4 -0.7 1.6 2.9 2.3 -0.5 -0.0 1.0
Time employed in main current job 0.2 0.3 1.0 0.6 1.0 0.3 -0.1 0.5 0.3 -0.4
Alcohol intake versus 10 years previously 0.7 1.1 5.5 0.4 0.7 0.4 1.1 0.3 -2.4 -0.4
Father’s age at death 1.2 1.6 8.6 0.5 -0.5 1.4 0.6 0.4 2.9 0.1
Worrier / anxious feelings 0.6 1.1 2.2 -1.1 0.3 0.6 -1.4 -1.0 -1.5 -0.9
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 4.3 1.5 2.1 1.8 1.9 1.3 0.8 -1.0
Falls in the last year 0.4 0.6 1.3 -1.1 -0.4 0.0 0.3 -1.2 -0.2 -1.1
Hair/balding pattern: Pattern 3 1.5 2.2 12.7 0.2 0.5 0.8 1.1 0.2 3.6 0.8
Number of live births 0.3 0.4 1.0 -0.3 1.0 -0.3 -0.8 0.0 0.6 -0.8
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 4.1 0.8 -2.0 1.3 0.1 0.6 -0.7 0.3
Pulse rate 0.6 1.0 5.5 -0.1 0.6 1.0 0.1 -0.2 0.4 -2.3
Happiness 1.0 1.3 3.3 -1.4 -0.6 1.0 -0.0 -1.4 0.5 1.8
Noisy workplace 1.9 2.4 4.8 -1.9 2.2 -0.6 0.0 -1.7 -1.1 -1.9
Qualifications: A levels/AS levels or equivalent 0.6 1.3 5.3 0.5 0.1 0.0 2.3 0.3 1.4 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.7 0.1 -0.6 -1.6 -0.4 0.4 0.9 0.6
Mouth/teeth dental problems: Dentures 2.5 4.2 13.0 1.9 3.6 0.3 2.4 2.5 0.2 0.4
Asthma 0.8 1.5 9.2 -0.1 -0.1 0.6 -0.8 -0.4 0.3 3.0
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 5.3 -1.7 -0.2 2.3 0.9 -1.6 -1.1 -0.5
Medication: Cholesterol lowering 1.0 1.5 3.6 1.2 1.3 -0.0 0.9 1.3 1.9 -1.2
Depression (self-reported) 0.4 0.5 1.0 -0.8 -0.6 0.7 0.3 -0.9 -0.1 -1.0
Medication: Lansoprazole 2.0 2.3 6.9 -0.8 2.6 -0.2 1.9 -0.5 0.7 -2.1
Prospective memory result 1.3 1.6 7.7 -0.4 -0.6 0.8 -1.1 -0.7 -0.6 -2.8
Lung cancer (father) 0.3 0.4 0.9 -0.2 0.8 0.7 0.7 -0.1 1.0 0.5
Illnesses of mother 0.8 0.9 2.0 1.4 0.7 -0.4 0.8 1.4 -0.6 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.4 7.1 0.3 -2.7 1.6 0.5 -0.1 0.2 -0.1
Pulse wave Arterial Stiffness index 0.9 1.1 2.7 0.8 1.6 -0.8 0.5 0.8 -0.8 -1.4
Impedance of arm (left) 0.4 1.8 11.5 0.2 -0.1 0.6 -0.5 -0.2 -3.4 -0.8
Arm fat mass (right) 0.4 1.6 4.3 0.0 1.3 1.8 2.1 0.1 -1.4 0.5
Trunk predicted mass 0.3 1.8 9.1 0.4 -0.8 0.2 1.2 0.2 -0.9 3.0
Standing height 0.4 4.2 14.6 1.1 -2.2 0.9 0.7 0.7 -3.8 2.7
Length of working week for main job 2.5 2.7 5.4 1.4 1.9 0.7 1.5 1.2 -2.3 2.0
Exposure to tobacco smoke at home 0.9 1.1 3.0 0.4 0.5 0.5 1.1 0.7 -1.4 -1.7
Breastfed as a baby 0.8 1.0 3.3 -0.9 -1.8 0.6 -0.5 -0.4 1.3 0.8
Tense / ‘highly strung’ 0.9 1.6 5.1 0.2 0.2 1.5 0.6 0.1 -1.8 -2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 3.3 0.2 1.8 -0.1 1.0 0.3 -0.0 -1.2
Hair/balding pattern: Pattern 4 0.8 2.0 5.2 1.2 2.3 0.2 0.3 1.6 -2.0 0.9
Birth weight of first child 0.4 0.7 1.5 0.4 1.0 -1.1 0.3 0.4 -1.2 0.8
Peak expiratory flow (PEF) 0.1 0.3 0.8 -0.2 -0.9 -0.4 -0.9 -0.4 -0.4 0.5
Pulse wave reflection index 0.5 0.6 2.0 0.6 0.5 -1.4 -0.6 0.5 -0.9 0.1
Ever highly irritable/argumentative for 2 days 0.5 0.5 1.7 -0.8 0.1 -0.7 -0.3 -0.7 -0.7 -1.3
Loud music exposure frequency 1.5 1.7 3.8 0.8 1.6 0.7 1.9 0.8 -1.5 -1.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 9.2 -0.4 -0.5 -0.1 -0.2 -0.3 -0.8 3.0
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.2 -0.4 -0.8 -0.8 -1.5 -0.7 0.6 -1.4
Blood clot in the leg (DVT) 0.6 0.8 1.7 1.3 1.1 -0.0 0.4 1.3 -0.2 1.1
Medication: Paracetamol 0.3 0.5 2.5 -0.3 0.8 0.5 0.3 -0.2 0.3 -1.6
Headache pain in last month 0.4 0.7 1.4 -0.7 0.3 0.7 0.9 -0.8 -1.2 1.1
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 4.3 -0.6 -1.3 0.2 -0.8 -0.8 -0.7 2.1
Glaucoma (self-reported) 12.8 15.0 29.1 -4.9 -4.9 -0.6 -5.4 -5.0 1.4 0.9
Gout (self-reported) 0.1 0.1 0.4 -0.2 0.6 -0.1 -0.1 -0.2 0.1 -0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 2.3 0.2 -0.1 -0.0 0.1 0.1 1.5 -0.7
Medication: Amlodipine 0.6 0.8 2.7 -0.9 -0.7 -0.3 -1.1 -0.6 -0.2 -1.6
Medication: Ventolin 100micrograms inhaler 1.1 1.4 4.9 -0.6 -0.3 -0.1 -0.7 -0.4 1.9 2.2
Birth weight 0.3 0.6 1.6 -0.5 -1.3 1.1 0.1 -0.7 0.2 0.6
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.0 0.5 -0.4 -0.8 0.2 0.3 -0.2 -1.0
High blood pressure (siblings) 0.3 0.5 1.9 0.4 0.3 0.6 -0.4 0.3 -1.4 -0.8
Forced vital capacity (FVC), Best measure 0.3 1.2 5.6 0.6 -2.4 1.3 0.9 0.1 0.2 0.5
Body fat percentage 0.4 1.7 4.1 -0.1 1.7 1.8 2.0 -0.0 -1.1 -0.5
Leg fat percentage (right) 0.4 1.3 3.9 0.1 2.0 1.0 1.8 0.2 0.1 -0.9
Arm fat-free mass (right) 0.3 1.4 6.5 -0.1 -0.2 0.5 1.7 -0.1 0.1 2.5
Exposure to tobacco smoke outside home 0.6 0.8 2.2 -0.5 -0.1 1.0 0.8 -0.4 -1.5 -1.0
Comparative body size at age 10 0.8 2.2 5.1 -2.1 -0.3 -0.2 -0.9 -1.9 2.3 1.1
Number of full brothers 0.6 0.8 3.6 -0.0 -1.1 -0.8 -0.1 0.1 0.1 -1.9
Worry too long after embarrassment 0.6 1.0 3.9 0.2 -0.5 1.6 -2.0 -0.1 0.4 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 0.1 -0.1 0.1 -0.0 0.2 0.3 -0.3
Wheeze or whistling in the chest in last year 0.4 0.8 2.3 0.3 0.1 1.5 0.1 0.2 -0.8 1.5
Number of children fathered 1.3 1.5 3.8 1.0 2.0 -0.1 0.8 1.4 -1.2 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.8 -0.6 -0.5 0.2 -0.7 -0.7 -0.1 -0.9
Age at first live birth 2.1 3.7 20.3 -0.7 -1.4 -0.3 -1.4 -0.9 -0.8 4.5
Pulse wave peak to peak time 1.0 1.1 2.9 -0.7 -1.7 0.8 -0.4 -0.8 0.7 1.7
Health satisfaction 0.2 0.3 0.6 -0.6 -0.3 0.8 0.6 -0.4 0.3 -0.7
Shortness of breath walking on level ground 1.3 1.6 3.9 0.5 2.0 1.9 1.3 0.6 -1.0 -0.8
Qualifications: College or University degree 0.2 0.7 3.7 0.3 -0.7 -0.8 -0.5 -0.1 0.1 1.9
Eye problems/disorders: None of the above 2.3 2.6 6.2 2.4 1.5 0.1 1.7 2.5 -1.0 -0.3
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.8 0.2 -0.5 0.7 0.3 0.3 -0.4 -0.9
Emphysema/chronic bronchitis 0.6 0.6 1.6 -1.2 -0.0 0.6 0.9 -0.9 0.8 0.5
Medication for pain relief, constipation, heartburn 1.8 3.1 7.7 -0.2 -2.0 -2.1 -2.3 -0.3 0.2 2.8
Neck or shoulder pain in last month 1.0 1.5 4.3 -2.1 0.5 -0.0 0.1 -1.9 1.2 -0.7
Medication: Blood pressure 0.6 1.1 6.1 0.3 0.2 0.9 0.5 0.4 -0.2 -2.5
Angina (self-reported) 0.7 1.0 5.0 -0.4 0.0 -0.5 -0.2 -0.0 -1.1 -2.2
Migraine (self-reported) 0.3 0.4 1.4 -0.3 -0.4 -0.0 -1.0 -0.4 -0.1 1.2
Medication: Ibuprofen 2.1 2.5 6.4 -2.5 -1.2 1.7 0.3 -2.4 -0.9 -0.6
Medication: Allopurinol 0.2 0.2 0.8 0.0 0.2 -0.6 -0.5 -0.1 -0.9 -0.3
Medication: Omeprazole 1.2 1.4 4.2 -0.5 1.8 0.8 2.1 -0.2 -0.2 -1.2
Medication: Seretide 50 evohaler 1.0 1.1 2.5 -0.8 -1.6 -0.3 -1.5 -0.9 -1.1 0.5
Mean time to correctly identify matches 0.6 1.2 3.5 0.6 1.6 0.2 1.1 0.6 0.5 1.9
Heart disease (mother) 0.3 0.4 1.9 -0.3 -0.7 -0.3 -0.4 -0.5 0.2 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 2.8 -0.3 0.9 1.0 0.2 -0.3 -1.1 -1.7
Whole body fat mass 0.5 1.9 5.6 0.1 1.4 2.0 2.4 0.1 -1.4 0.4
Leg fat mass (right) 0.4 1.5 5.1 0.3 1.6 1.6 2.3 0.3 -0.5 -0.0
Arm predicted mass (right) 0.3 1.5 7.0 -0.2 -0.4 0.7 1.7 -0.2 -0.1 2.6
Pulse rate, automated reading 0.6 1.8 7.0 -1.1 -1.2 0.6 -0.6 -1.2 -0.7 -2.6
Alcohol intake frequency. 1.1 2.5 8.3 0.4 2.3 1.0 2.9 0.3 -1.6 -0.2
Comparative height size at age 10 0.5 2.7 7.6 1.6 -1.2 0.9 1.1 1.3 -2.0 2.8
Number of full sisters 0.8 1.0 5.7 -0.3 -0.1 0.1 0.6 0.1 1.0 -2.4
Suffer from ‘nerves’ 0.5 0.9 2.1 1.2 -0.7 0.9 0.2 1.1 0.2 -1.4
Overall health rating 0.5 1.0 3.8 -0.1 1.9 -0.9 0.8 0.1 0.4 -1.3
Chest pain or discomfort 0.6 0.9 3.8 -0.4 0.2 0.4 -0.2 -0.6 -1.9 -1.5
Had major operations 0.9 1.0 5.4 0.1 0.9 -0.3 0.5 0.4 2.3 -0.6
Age at last live birth 0.8 1.2 6.9 0.1 -0.4 -1.0 -0.6 -0.1 -0.4 2.6
Family relationship satisfaction 0.3 0.3 1.0 -0.8 -0.4 0.2 -0.3 -0.6 -1.0 0.2
Leg pain on walking 0.9 1.1 3.3 -0.4 1.8 0.6 1.6 -0.3 0.5 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.6 -1.6 -0.5 -0.0 -0.3 -1.4 0.0 -0.2
Commuting to job workplace: Car/motor vehicle 1.4 1.7 6.9 0.0 0.0 1.3 -0.1 0.2 1.7 -2.6
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.4 0.3 -0.4 -0.4 -1.5 0.1 0.2 -1.5
Medication: Aspirin 2.9 3.9 9.5 1.7 1.9 1.9 1.8 1.6 -1.4 -3.1
Supplements: Vitamin C 0.4 0.5 1.7 1.0 0.2 0.8 0.2 1.3 0.0 0.4
Knee pain experienced in last month 0.5 0.8 2.6 0.1 1.6 -0.6 0.7 0.3 1.1 -1.0
Hypertension (Self-reported) 0.3 0.9 3.0 0.3 1.5 -0.1 0.8 0.5 -0.3 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 2.6 -1.3 1.6 -0.9 1.1 -1.0 0.3 -0.9
Illnesses of father: Heart disease 0.9 1.2 5.2 0.7 1.1 -0.0 2.3 0.7 0.4 0.9
Illnesses of siblings: Diabetes 1.5 1.9 3.9 1.8 1.4 -0.5 0.1 2.0 1.7 1.0
Smoking status: Previous 0.5 0.8 2.1 -0.4 0.8 1.0 1.5 0.1 -0.9 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.8 -0.3 -1.5 -1.4 -0.1 -0.6 -1.7 1.5
Whole body fat-free mass 0.3 1.8 8.3 0.2 -0.5 0.8 1.6 0.1 -0.9 2.9
Leg fat-free mass (right) 0.3 1.6 6.6 -0.3 -0.2 1.1 1.6 -0.3 -1.0 2.6
Arm fat percentage (left) 0.4 1.7 4.3 -0.2 1.7 1.9 2.1 -0.1 -1.1 -0.1
Average weekly red wine intake 1.3 1.9 5.8 -0.2 0.0 -2.2 -1.1 -0.3 2.4 1.2
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.7 0.1 0.0 1.2 0.1 -0.1 1.3 -0.3
Mood swings 0.3 0.5 1.5 0.1 1.2 0.7 1.0 0.1 -0.3 0.5
Loneliness, isolation 1.0 1.4 4.2 -2.0 -0.9 -0.1 -0.2 -1.9 -0.1 -1.1
Long-standing illness, disability or infirmity 0.5 0.8 1.5 -1.2 0.8 -1.0 -0.8 -1.0 0.7 -0.6
Ever had bowel cancer screening 1.6 1.9 6.8 -0.6 -0.3 -2.6 -1.1 -0.8 -0.1 -2.0
Diabetes diagnosed by doctor 0.6 1.0 2.4 0.7 0.7 0.9 0.1 1.0 1.2 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.9 0.8 0.7 0.1 1.2 0.8 -1.4 -0.2
Friendships satisfaction 0.4 0.5 1.4 -0.5 -0.3 0.6 -0.4 -0.4 1.2 0.9
Qualifications: nursing, teaching 1.0 1.6 8.0 -0.5 -0.4 -1.1 -1.0 -0.6 0.1 2.8
Commuting to job workplace: Walk 0.2 0.2 1.1 0.4 0.0 -0.5 0.4 0.2 -1.0 0.1
Eye problems/disorders: Cataract 0.4 0.5 1.2 -0.2 1.1 -0.2 1.1 0.0 1.0 0.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.3 -1.0 1.0 1.5 0.1 -1.1 0.5 -1.1
Medication for cholesterol 0.3 0.4 0.8 0.9 0.4 0.7 0.3 0.8 -0.5 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.4 0.9 -0.1 -0.4 0.3 0.8 0.8 1.2
Back pain experienced in last month 3.9 5.6 12.3 2.2 3.5 2.5 3.0 2.2 0.3 -1.5
Mineral and other dietary supplements 0.2 0.2 0.9 0.4 0.1 0.2 0.5 0.1 -0.4 1.0
Breast cancer (self-reported) 0.3 0.4 1.8 0.3 -0.0 0.2 1.4 0.3 0.3 -0.8
Asthma (self-reported) 0.5 1.1 6.5 0.2 0.4 0.3 -0.8 -0.0 0.3 2.5
Osteoporosis (self-reported) 0.8 1.0 3.2 -0.5 -0.5 -1.5 -0.9 -0.3 -0.3 1.8
Osteoarthritis (self-reported) 1.4 1.8 6.0 0.6 1.3 0.8 -0.8 0.7 1.6 -2.4
Medication: Aspirin 2.8 3.7 10.4 1.5 2.0 1.8 1.1 1.5 -1.6 -3.2
Medication: Gliclazide 0.3 0.4 0.8 0.6 -0.9 0.8 0.5 0.6 -0.3 -0.2
Illnesses of father: None of the above (group 1) 0.8 1.0 5.4 0.3 -0.7 -0.0 -0.8 0.2 -2.3 0.6
Smoking status: Current 0.6 0.9 2.6 -0.6 0.9 -1.5 1.6 -0.2 -0.3 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 6.9 0.6 -0.1 2.6 0.4 0.4 1.4 -1.5
Whole body water mass 0.3 1.8 8.6 0.1 -0.6 0.7 1.5 0.0 -0.8 2.9
Leg predicted mass (right) 0.3 1.6 6.2 -0.2 -0.1 1.1 1.6 -0.2 -0.9 2.5
Arm fat mass (left) 0.3 1.4 3.6 -0.4 1.1 1.8 1.9 -0.4 -1.0 0.6
Number of self-reported non-cancer illnesses 0.8 1.4 2.7 -1.3 1.4 -0.3 1.0 -1.1 1.1 -1.6
Average weekly champagne plus white wine intake 1.1 1.6 5.5 -0.4 -0.5 1.7 0.8 -0.5 1.2 2.3
Miserableness 1.4 2.4 5.4 -2.3 -1.3 0.6 -1.4 -2.2 -0.7 -1.4
Guilty feelings 0.7 1.0 2.5 -0.7 -1.6 0.1 -1.1 -0.7 0.9 1.2
Wears glasses or contact lenses 0.6 0.7 1.9 0.3 0.0 1.4 -0.1 0.4 1.1 -1.3
Ever taken oral contraceptive pill 0.6 0.6 2.8 -0.3 -1.7 0.1 -0.8 -0.7 -0.4 -0.4
Hearing aid user 1.2 1.4 3.1 1.3 1.5 0.4 -0.5 1.4 -1.8 0.1
Mother’s age at death 2.4 3.0 6.2 -2.1 -1.6 -1.5 -1.4 -1.9 -0.6 2.5
Financial situation satisfaction 0.9 1.1 6.2 -0.3 0.1 -1.0 0.5 -0.4 -2.5 -0.2
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.0 -0.6 0.5 -1.0 -0.7 -0.5 0.6 -0.9
Commuting to job workplace: Public transport 0.4 0.5 2.1 -0.3 -0.4 -0.9 -0.3 -0.3 0.3 1.5
Eye problems/disorders: Glaucoma 10.9 12.9 25.1 -4.3 -5.0 0.1 -4.8 -4.5 0.9 1.6
Medication: Blood pressure 0.3 0.6 1.1 0.8 1.0 -0.5 -0.1 1.0 -0.2 -1.0
Pain type(s) experienced in last month: Hip pain 1.5 1.9 8.4 -0.2 2.9 0.2 2.1 0.0 -0.0 0.0
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.9 0.3 0.8 0.2 0.4 0.6 -0.3 -0.9
High cholesterol (Self-reported) 1.1 1.9 3.1 1.6 1.3 1.2 1.5 1.8 1.3 -0.5
Medication: Bendroflumethiazide 0.4 0.6 1.5 -0.9 -0.6 0.6 -0.6 -0.9 -0.3 -1.2
Medication: Paracetamol 0.3 0.5 2.3 -0.7 0.3 0.4 0.1 -0.6 0.4 -1.5
Medication: Lisinopril 1.4 1.8 4.7 -0.3 -0.7 -2.2 -1.5 -0.3 1.2 -1.9
Medication: Atorvastatin 0.4 0.5 2.7 0.1 -0.2 -0.4 0.1 0.3 1.7 -0.5
Illnesses of father: High blood pressure 0.6 0.7 2.7 -0.9 -0.6 0.0 0.0 -1.0 0.0 -1.6
Alcohol drinker status: Never 0.5 0.6 1.1 -0.8 1.1 1.0 0.7 -0.9 -0.4 0.0
Ever smoked 0.4 0.7 2.5 0.2 0.2 0.5 1.6 0.6 -1.0 -0.6
Basal metabolic rate 0.3 1.7 6.2 0.2 -0.2 1.0 1.8 0.1 -1.1 2.5
Leg fat percentage (left) 0.4 1.3 3.7 -0.2 1.9 1.2 1.7 -0.1 -0.1 -0.8
Arm fat-free mass (left) 0.2 1.0 4.8 -0.2 -0.7 0.4 1.1 -0.2 -0.1 2.2
Number of operations (self-reported) 0.2 0.4 0.9 -0.3 0.7 -0.9 -0.8 -0.2 0.0 -0.6
Average weekly beer plus cider intake 1.6 2.3 5.5 1.0 2.1 1.0 2.3 0.9 0.7 -1.7
Irritability 0.9 1.5 4.5 0.9 1.5 1.6 2.1 0.9 0.0 -0.4
Risk taking 0.3 0.4 0.7 -0.8 0.6 0.9 0.6 -0.6 0.2 0.4
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.3 1.5 1.5 0.4 0.5 1.5 0.4 -1.0
Fractured/broken bones in last 5 years 1.6 2.1 4.1 -2.0 -2.0 -1.2 -1.3 -1.6 -0.4 0.8
Age started oral contraceptive pill 0.5 0.6 1.8 1.0 -0.2 -0.6 -0.4 0.8 1.3 -0.5
Diastolic blood pressure, automated reading 0.6 1.9 2.6 -1.6 -1.6 -1.4 -1.0 -1.6 0.9 -1.2
Ever depressed for a whole week 0.9 1.1 3.1 -0.9 1.8 -0.4 0.3 -0.9 -0.2 -1.6
Unable to work because of sickness or disability 0.2 0.3 0.9 -0.9 -0.1 -0.5 -0.3 -0.9 0.3 -0.4
Commuting to job workplace: Cycle 0.6 0.8 1.6 -0.7 -1.0 -0.7 -0.6 -0.6 -1.2 1.1
Myopia 0.8 1.2 3.4 0.4 -1.8 0.5 -1.1 0.5 -0.3 -1.8
Vascular/heart problems diagnosed by doctor 0.6 1.7 5.7 -0.1 -1.9 0.2 -1.4 -0.5 0.5 2.4
Cholesterol lowering medication 0.7 1.0 2.9 1.0 1.0 0.0 1.7 1.2 0.6 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 4.1 -0.4 1.6 0.7 2.0 -0.1 -0.0 -1.4
Pain experienced in last month 0.9 1.5 4.2 0.6 -2.0 0.1 -1.6 0.5 -0.4 1.7
Supplements: Calcium 1.3 1.4 3.8 -0.9 -1.9 -0.7 -0.9 -0.8 -1.1 1.5
Basal cell carcinoma (self-reported) 0.8 0.9 2.1 0.7 1.1 0.1 1.1 0.8 -0.9 -1.5
Heart attack/myocardial infarction (self-reported) 1.7 2.2 10.9 -0.1 0.5 -0.9 1.2 0.2 -1.3 -3.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.3 1.1 0.6 0.1 0.1 1.1 -0.1 0.9
Heart disease (siblings) 0.5 0.6 1.1 -0.9 0.5 -1.1 -0.3 -1.0 0.7 -0.9
Alcohol drinker status: Previous 1.1 1.2 6.0 0.2 0.4 0.0 2.4 0.2 0.6 1.4
Pack years of smoking 0.6 0.8 2.2 1.0 -0.7 -0.4 -0.8 1.1 0.4 -1.5
Impedance of whole body 0.2 1.3 5.6 0.1 -0.5 0.1 -1.0 -0.2 -2.4 -1.4
Leg fat mass (left) 0.4 1.4 4.7 0.0 1.4 1.6 2.2 0.1 -0.8 0.0
Arm predicted mass (left) 0.3 1.4 7.3 -0.1 -0.6 0.5 1.2 -0.2 -0.2 2.7