Hub : Genes

Y_RNA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.150	0.0500	1.2e-03	0.079	NA	0.008	NA	0.048	8.7e-07	NA	6.6e-02	NA	1.1e-04
2	GTEx	Breast Mammary Tissue (Male)	0.234	0.1228	2.5e-02	-0.010	NA	-0.013	NA	-0.008	6.6e-01	NA	8.6e-01	NA	5.6e-01
3	GTEx	Colon Sigmoid	0.361	0.0790	1.1e-05	0.067	NA	0.227	NA	0.179	2.2e-03	NA	1.5e-08	NA	6.4e-07
4	GTEx	Esophagus Mucosa	0.189	0.0610	9.5e-04	0.064	NA	0.126	NA	0.122	4.4e-05	NA	9.7e-09	NA	1.6e-08
5	GTEx	Muscle Skeletal	0.113	0.0346	3.0e-04	0.031	NA	0.061	NA	0.047	4.2e-04	NA	1.3e-06	NA	2.2e-05
6	GTEx	Nerve Tibial	0.197	0.0565	1.7e-04	0.155	NA	0.077	NA	0.141	4.4e-11	NA	4.2e-06	NA	3.3e-10
7	GTEx	Thyroid	0.175	0.0710	5.4e-04	0.038	NA	0.062	NA	0.078	6.3e-04	NA	1.5e-05	NA	1.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.7	2.2	0.0	-0.1	1.1	-0.0	0.1	-1.1	-1.5
Bipolar Disorder or Schizophrenia	0.7	1.7	4.8	-0.4	-1.4	-0.6	-2.1	-0.2	-0.5	-2.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.4	-0.7	-0.3	0.7	0.3	-0.5	-0.5	-1.2
Depression (Nagel 2018)	0.4	0.5	1.2	-1.0	-0.2	0.2	0.6	-0.8	0.8	-1.1
Intelligence (Savage-Jansen 2018)	1.7	5.1	8.1	-1.8	-2.6	-2.7	-2.8	-1.9	2.1	1.7
Neuroticism (Nagel 2018)	0.3	0.7	2.4	0.6	0.7	1.5	0.5	0.7	-0.6	-0.9
Schizophrenia (2018)	1.1	2.3	7.1	-0.6	-1.7	-1.6	-2.7	-0.4	0.3	-1.6
Schizophrenia vs Biploar Disorder	1.0	1.3	4.8	-0.5	-1.7	-2.2	-0.5	-0.4	-0.9	0.6
Worry (Nagel 2018)	0.4	0.9	1.8	0.4	0.8	1.3	0.4	0.7	-1.2	-1.3
Alzheimer’s Disease (in mother)	0.8	1.0	4.4	0.3	2.1	0.7	1.2	0.4	-0.4	-0.1
Alzheimer’s Disease (in father)	1.0	1.1	3.1	1.2	0.7	-0.9	0.6	1.2	1.8	0.4
Alzheimer’s Disease (including proxy)	0.7	1.0	2.7	0.7	1.6	0.6	1.6	0.7	0.9	0.0
Crohns Disease (2017)	0.4	0.8	3.7	0.0	-0.8	0.2	-0.8	0.3	-0.7	-1.9
Irritable Bowel Disease (IBD)	0.5	1.2	3.6	0.8	-0.3	-0.9	-1.2	1.1	-0.5	-1.9
Ulcerative Colitis (UC)	0.8	1.5	3.4	0.5	-0.5	-1.6	-1.9	0.7	0.1	-1.8
Major Depression (MDD)	1.2	1.5	4.1	-0.7	1.2	-1.8	-0.0	-0.5	1.0	-2.0
Reaction Time	0.3	0.6	3.4	0.1	0.8	-0.3	0.1	0.0	0.3	1.8
Verbal and Numeric Reasoning (VNR)	1.4	3.3	9.3	-1.0	-1.2	-2.7	-1.7	-1.0	3.1	0.7
Breast Cancer	0.8	1.9	5.7	-0.7	-2.4	0.3	-1.7	-0.9	1.6	1.0
Ovarian Cancer	2.5	3.3	11.5	-1.5	-3.4	-0.6	-2.3	-1.6	-0.2	-0.9
Prostate Cancer	0.8	1.2	3.5	0.6	1.9	0.3	0.6	0.4	-1.1	1.5
Age at First Birth	1.0	1.5	5.2	-0.0	-1.0	-0.6	-2.3	-0.1	-0.5	1.9
Bipolar Disorder (2011)	0.5	0.5	1.8	0.3	0.8	1.3	-0.3	0.5	-0.8	0.0
Body Mass Index (BMI) (2010)	2.1	2.8	5.9	1.6	1.6	1.2	2.4	1.7	-0.5	2.0
Coronary Artery Disease (CAD)	0.2	0.3	0.9	-0.3	0.4	0.9	-0.3	-0.2	0.3	-0.7
Crohns Disease (2012)	0.3	0.4	1.2	0.6	-0.1	0.1	-1.1	0.8	-0.1	-0.8
Mean Putamen Volume	0.7	0.8	2.2	-1.0	-0.9	1.5	0.7	-0.7	-0.0	0.7
Fasting Glucose	0.7	0.9	4.3	-0.1	1.0	0.6	-0.2	-0.0	-2.1	0.5
HbA1C	0.3	0.3	1.4	-0.2	0.6	1.2	0.2	-0.3	0.4	0.4
HDL Cholesterol	0.5	0.9	3.0	-0.0	-0.5	0.8	-0.4	-0.2	-1.4	1.7
LDL Cholesterol	0.6	1.0	1.8	1.3	1.0	0.6	1.2	1.4	-0.4	-0.3
Lupus	0.6	0.9	3.1	-0.5	-1.8	-1.0	-1.4	-0.4	0.3	0.2
Neuroticism (2016)	0.9	1.3	4.5	-0.5	-1.2	2.1	-1.0	-0.5	-0.1	-1.2
Primary Biliary Cirrhosis	1.2	1.6	3.4	1.4	0.3	1.7	1.1	1.3	1.8	-0.3
Rheumatoid Arthritis	0.6	0.8	2.1	0.2	1.5	0.2	1.3	0.3	-0.2	1.3
Schizophrenia (2014)	0.9	1.9	5.4	-0.7	-1.6	-1.8	-2.3	-0.6	-0.0	-1.1
Triglycerides	0.7	1.2	5.1	0.7	-0.3	-0.6	-1.3	0.8	0.2	-2.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.9	0.1	0.1	-0.2	-0.9	0.1	1.1	1.7
Ulcerative Colitis	0.5	0.8	2.6	1.5	0.7	0.1	-0.4	1.6	-0.1	0.1
Blood Eosinophil Count	0.4	3.1	15.0	-0.6	-0.6	-1.3	-2.0	-0.7	0.0	3.9
Blood Platelet Count	0.1	0.9	1.9	-0.6	-1.2	1.1	-0.4	-0.8	0.8	-1.4
Blood Red Count	0.2	2.4	9.1	1.3	0.4	0.2	0.4	1.1	-2.1	-3.0
Blood White Count	0.1	0.9	4.3	0.8	-0.7	-0.3	-0.6	0.8	-2.1	-0.1
Heel T-Score	0.6	5.1	15.7	1.6	0.9	1.6	0.6	1.4	-4.0	-3.4
BMI	0.3	1.6	4.7	0.0	2.2	1.3	1.7	0.2	1.1	1.0
Height	0.2	3.4	14.6	1.4	-1.8	1.3	0.6	0.9	-3.8	1.1
Waist Hip Ratio (WHR)	1.6	7.3	16.5	2.0	3.5	-3.2	0.7	2.3	-4.1	-1.5
Systolic Blood Pressure	0.1	0.7	1.7	1.1	0.6	-0.7	1.3	1.1	0.0	-0.5
Smoking Status	0.3	0.8	3.1	-0.3	0.6	-1.2	1.8	0.4	-0.0	-0.8
Allergy or Eczema	0.4	1.0	3.0	-0.2	-0.0	1.6	0.2	-0.5	-1.1	1.7
Cardiovascular Disease	1.1	3.5	9.2	1.9	2.4	-0.2	3.0	2.2	-1.1	0.3
Hypothyroidism (self reported)	0.4	0.9	3.4	-0.8	-1.1	0.1	-0.6	-0.7	1.9	-0.7
Respiratory disease	0.6	1.3	8.6	-0.4	-0.2	0.1	-0.3	-0.4	0.4	2.9
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.2	1.2	1.2	1.3	0.1	1.5	0.9	-2.0
Lung FEV1/FVC ratio	0.0	0.2	0.6	0.2	0.1	0.8	-0.0	0.3	0.8	-0.3
Lung FVC	0.5	2.8	6.5	1.9	-0.6	2.3	1.3	1.5	2.5	0.2
Neuroticism	0.5	1.1	4.5	-0.2	0.1	2.1	0.6	-0.0	-1.6	-0.5
Chronotype (morning person)	0.5	1.1	2.0	1.2	-0.7	1.2	0.5	0.8	1.4	1.1
Hair Pigment	0.0	1.4	7.3	0.3	-0.5	0.4	-1.4	0.2	-2.7	-0.0
Tanning	0.2	1.9	11.2	-1.3	-0.1	0.2	-0.1	-0.8	3.3	0.4
Hand grip strength (left)	0.3	0.9	2.7	0.1	-1.5	-0.9	0.3	-0.1	-1.7	0.7
Number of treatments/medications taken	0.5	0.8	2.6	-1.3	0.4	0.2	0.0	-1.2	-0.0	-1.6
Average weekly spirits intake	0.4	0.5	2.2	0.7	0.4	1.5	0.3	0.7	0.2	0.0
Sensitivity / hurt feelings	1.9	3.2	7.0	2.6	2.4	0.9	1.1	2.6	0.3	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	-1.2	-0.8	-0.1	0.0	-1.4	0.9	-0.4
Hearing difficulty/problems: Yes	2.1	3.2	18.1	0.1	4.2	-0.7	1.0	0.0	-1.6	-0.6
Relative age of first facial hair	0.9	1.8	4.2	0.8	-0.6	1.6	-0.2	1.0	-1.9	-2.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.2	-0.1	1.5	0.3	1.0	0.0	1.5	-0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.8	-0.9	0.1	0.3	-0.2	-0.6	0.1	0.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	0.1	1.3	0.9	1.3	0.1	-0.1	-0.1
Systolic blood pressure, automated reading	0.2	0.7	3.2	0.1	-0.4	-1.0	-0.1	0.1	1.8	-0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.9	-1.0	-0.6	-0.6	-0.1	-0.8	-0.9	-0.8
Angina	0.6	0.8	5.1	-0.4	0.4	-0.1	0.1	-0.0	-0.6	-2.3
Medication for hormone replacement therapy	2.7	3.0	6.4	-1.9	-2.0	-1.1	-1.4	-2.0	0.1	2.5
Vitamin and mineral supplements	1.1	1.4	3.0	-0.8	-1.7	-1.2	-1.1	-1.0	-0.0	-1.7
Supplements: Zinc	1.8	1.9	3.5	-1.9	-1.5	-0.7	-1.0	-1.8	-0.7	1.5
Medication: Co-codamol	0.5	0.5	0.8	-0.8	0.4	-0.6	-0.8	-0.7	0.8	-0.9
Medication: Metformin	0.6	0.9	4.1	0.7	0.0	0.1	-0.4	0.9	2.0	-0.8
Diabetes (father)	1.1	1.3	2.0	-1.3	-1.4	1.2	-0.8	-1.4	1.3	0.3
Diabetes (mother)	0.7	0.9	2.4	-1.0	-0.8	-1.6	-1.0	-0.8	0.7	-0.5
Severe depression (siblings)	0.7	0.8	1.6	0.8	0.6	1.1	1.3	0.7	0.3	1.1
Pack years adult smoking proportion	0.3	0.5	0.8	0.7	-0.9	-0.5	-0.9	0.9	0.0	-0.8
Impedance of leg (right)	0.2	1.1	2.7	0.8	-0.7	-0.8	-0.9	0.5	-1.5	-1.6
Leg fat-free mass (left)	0.3	1.8	6.2	0.1	0.2	1.2	1.9	0.1	-1.1	2.5
Trunk fat percentage	0.4	1.7	4.0	-0.4	1.2	2.0	1.8	-0.4	-1.7	-0.4
Hand grip strength (right)	0.4	1.2	4.9	0.6	-0.8	-1.1	0.3	0.6	-2.2	0.9
Townsend deprivation index at recruitment	0.6	0.9	3.1	-0.8	-0.0	0.6	-0.0	-0.5	-1.3	-1.8
Current tobacco smoking	0.6	1.0	3.7	-0.3	1.0	-1.4	1.9	0.1	-0.2	-0.6
Average weekly fortified wine intake	0.2	0.3	0.8	0.1	0.8	-0.2	0.5	0.2	-0.1	0.9
Maternal smoking around birth	1.0	1.4	3.4	-0.4	1.1	-1.4	0.7	-0.0	-1.9	-1.7
Fed-up feelings	0.2	0.4	1.4	-0.4	-0.5	0.7	0.5	-0.4	0.3	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.0	-2.0	-0.7	0.2	-0.2	-1.8	0.2	-1.8
Relative age voice broke	0.7	1.1	1.7	1.0	1.3	1.0	-0.0	1.1	0.9	-1.3
Taking other prescription medications	0.1	0.2	0.5	0.3	0.7	-0.4	-0.4	0.3	-0.5	-0.2
Age when periods started (menarche)	0.7	1.7	5.0	0.8	0.4	-2.2	-1.4	0.5	-0.6	-1.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.9	-0.1	-0.0	1.4	-0.6	-0.1	0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	11.3	2.1	1.2	0.7	0.7	1.8	-3.4	-1.3
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	4.6	2.1	0.2	1.5	1.5	1.9	0.5	-1.1
Qualifications: CSEs or equivalent	0.6	0.8	2.8	-0.7	1.7	1.1	1.0	-0.6	-0.5	0.1
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-0.6	-0.8	0.6	0.6	-0.6	-1.2	0.1
High blood pressure	0.3	0.9	3.1	0.4	1.8	0.1	0.8	0.6	-0.0	-1.5
Hayfever, allergic rhinitis or eczema	0.6	1.3	7.1	-0.4	-0.8	0.2	-0.6	-0.9	-0.1	2.7
Multivitamins +/- minerals	1.1	1.4	4.5	0.2	2.1	0.3	0.9	0.4	-0.1	2.1
Stomach or abdominal pain in last month	0.7	0.9	2.6	-1.3	0.7	-1.0	-0.0	-1.6	-0.7	-0.0
Supplements: Glucosamine	0.6	0.8	1.9	1.0	0.0	1.3	0.0	0.9	1.4	-0.4
Diverticular disease/diverticulitis (self-reported)	2.7	3.3	7.6	1.7	1.8	2.8	2.2	1.8	0.0	-1.0
Medication: Atenolol	1.9	2.3	4.0	1.6	2.0	0.4	1.9	1.9	-0.5	-1.4
Medication: Levothyroxine sodium	0.3	0.5	1.0	-0.4	-0.9	-0.3	-1.0	-0.4	0.8	-1.0
Sitting height	0.4	2.8	10.3	0.9	-2.1	1.8	0.2	0.6	-0.7	3.2
Chronic bronchitis/emphysema (father)	1.0	1.2	5.8	-0.4	0.8	-0.2	0.2	0.0	1.4	-2.4
High blood pressure (mother)	1.3	1.8	3.1	-1.8	-1.6	-0.3	-1.4	-1.6	-0.1	1.5
Body mass index (BMI)	0.3	1.4	3.7	-0.4	1.8	1.6	1.9	-0.2	0.6	0.2
Impedance of leg (left)	0.2	1.0	2.7	0.3	-0.8	-0.8	-0.9	0.0	-1.5	-1.6
Leg predicted mass (left)	0.3	1.8	6.0	0.1	0.2	1.4	1.9	0.1	-1.0	2.5
Trunk fat mass	0.4	1.8	4.3	-0.2	1.0	1.9	2.1	-0.2	-1.8	0.2
Waist circumference	0.5	1.8	5.4	-0.2	2.3	0.4	1.8	0.1	-1.8	-0.6
Number of incorrect matches in round	0.3	0.5	1.1	-0.2	0.2	0.9	-1.0	-0.4	0.6	-0.9
Past tobacco smoking	0.5	0.9	3.0	0.5	-0.6	-0.4	-1.7	-0.0	1.2	0.9
Alcohol usually taken with meals	2.1	3.5	7.3	-1.0	-2.3	-1.7	-2.5	-0.9	0.8	2.7
Nervous feelings	0.3	0.6	1.1	1.0	0.1	1.1	-0.4	1.1	0.8	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.6	-0.8	1.4	-0.4	1.0	-1.0	-1.6	-0.4
Hearing difficulty/problems with background noise	1.7	2.7	15.3	1.2	3.9	0.2	1.1	1.1	0.1	0.3
Hair/balding pattern: Pattern 2	1.6	2.0	5.1	-1.4	-1.7	-0.9	-2.3	-1.4	-1.0	0.6
Had menopause	0.2	0.3	0.4	0.5	-0.6	0.6	0.3	0.6	0.6	-0.5
Had other major operations	0.5	0.7	3.8	-0.3	0.1	-0.4	-0.3	-0.3	-0.6	-2.0
Forced vital capacity (FVC)	0.3	1.1	2.9	1.1	-1.7	1.1	0.7	0.8	-0.8	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	9.8	1.1	0.5	0.4	0.2	0.8	-3.1	-1.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.5	0.7	0.4	-0.4	-0.4	-0.9	0.1
Qualifications: None of the above	1.4	3.0	12.7	0.9	1.7	0.8	1.6	1.0	-0.4	-3.6
Financial difficulties in last 2 years	0.7	1.0	2.7	-0.3	1.2	1.5	1.6	-0.4	0.4	0.1
Mouth/teeth dental problems	1.0	1.5	4.3	-0.9	-1.7	-0.5	-0.9	-1.0	-0.8	2.1
Heart attack	1.8	2.4	12.4	-0.4	0.4	-1.0	1.1	-0.2	-1.3	-3.5
Allergy	0.7	1.6	9.0	0.6	0.7	-0.6	0.7	0.9	-0.1	-3.0
Pain all over the body in last month	2.3	2.4	6.9	-1.8	0.0	0.2	-0.6	-2.0	1.6	-2.6
Diabetes (self-reported)	0.9	1.4	3.8	1.0	1.2	1.1	0.0	1.2	1.1	-2.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.7	0.2	-0.3	0.9	-0.3	0.1	1.6	1.4
Medication: Ramipril	1.3	1.6	2.5	1.2	1.2	1.4	1.2	1.6	-0.8	-1.5
Medication: Simvastatin	0.3	0.4	1.2	0.4	0.6	0.4	0.7	0.4	0.0	-1.1
Fluid intelligence score	0.6	1.2	2.3	-1.1	-0.7	-1.1	-1.0	-1.0	1.5	1.2
Illnesses of siblings	0.2	0.3	0.6	-0.8	-0.6	-0.1	-0.1	-0.6	0.3	0.6
Neuroticism score	0.3	0.7	2.2	-0.2	0.1	1.5	-0.3	-0.2	-0.8	-1.4
Weight	0.3	1.4	3.7	-0.1	0.5	1.8	1.9	-0.1	-1.1	1.3
Impedance of arm (right)	0.5	2.4	13.7	0.2	-0.6	0.2	-1.2	-0.1	-3.7	-1.0
Arm fat percentage (right)	0.4	1.4	3.1	-0.1	1.6	1.7	1.7	-0.0	-1.2	-0.2
Trunk fat-free mass	0.3	1.7	8.5	0.4	-0.9	0.4	1.2	0.3	-0.9	2.9
Hip circumference	0.6	2.6	8.4	-0.7	1.6	2.9	2.3	-0.5	-0.0	1.0
Time employed in main current job	0.2	0.3	1.0	0.6	1.0	0.3	-0.1	0.5	0.3	-0.4
Alcohol intake versus 10 years previously	0.7	1.1	5.5	0.4	0.7	0.4	1.1	0.3	-2.4	-0.4
Father’s age at death	1.2	1.6	8.6	0.5	-0.5	1.4	0.6	0.4	2.9	0.1
Worrier / anxious feelings	0.6	1.1	2.2	-1.1	0.3	0.6	-1.4	-1.0	-1.5	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.3	1.5	2.1	1.8	1.9	1.3	0.8	-1.0
Falls in the last year	0.4	0.6	1.3	-1.1	-0.4	0.0	0.3	-1.2	-0.2	-1.1
Hair/balding pattern: Pattern 3	1.5	2.2	12.7	0.2	0.5	0.8	1.1	0.2	3.6	0.8
Number of live births	0.3	0.4	1.0	-0.3	1.0	-0.3	-0.8	0.0	0.6	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.1	0.8	-2.0	1.3	0.1	0.6	-0.7	0.3
Pulse rate	0.6	1.0	5.5	-0.1	0.6	1.0	0.1	-0.2	0.4	-2.3
Happiness	1.0	1.3	3.3	-1.4	-0.6	1.0	-0.0	-1.4	0.5	1.8
Noisy workplace	1.9	2.4	4.8	-1.9	2.2	-0.6	0.0	-1.7	-1.1	-1.9
Qualifications: A levels/AS levels or equivalent	0.6	1.3	5.3	0.5	0.1	0.0	2.3	0.3	1.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.7	0.1	-0.6	-1.6	-0.4	0.4	0.9	0.6
Mouth/teeth dental problems: Dentures	2.5	4.2	13.0	1.9	3.6	0.3	2.4	2.5	0.2	0.4
Asthma	0.8	1.5	9.2	-0.1	-0.1	0.6	-0.8	-0.4	0.3	3.0
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	5.3	-1.7	-0.2	2.3	0.9	-1.6	-1.1	-0.5
Medication: Cholesterol lowering	1.0	1.5	3.6	1.2	1.3	-0.0	0.9	1.3	1.9	-1.2
Depression (self-reported)	0.4	0.5	1.0	-0.8	-0.6	0.7	0.3	-0.9	-0.1	-1.0
Medication: Lansoprazole	2.0	2.3	6.9	-0.8	2.6	-0.2	1.9	-0.5	0.7	-2.1
Prospective memory result	1.3	1.6	7.7	-0.4	-0.6	0.8	-1.1	-0.7	-0.6	-2.8
Lung cancer (father)	0.3	0.4	0.9	-0.2	0.8	0.7	0.7	-0.1	1.0	0.5
Illnesses of mother	0.8	0.9	2.0	1.4	0.7	-0.4	0.8	1.4	-0.6	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	7.1	0.3	-2.7	1.6	0.5	-0.1	0.2	-0.1
Pulse wave Arterial Stiffness index	0.9	1.1	2.7	0.8	1.6	-0.8	0.5	0.8	-0.8	-1.4
Impedance of arm (left)	0.4	1.8	11.5	0.2	-0.1	0.6	-0.5	-0.2	-3.4	-0.8
Arm fat mass (right)	0.4	1.6	4.3	0.0	1.3	1.8	2.1	0.1	-1.4	0.5
Trunk predicted mass	0.3	1.8	9.1	0.4	-0.8	0.2	1.2	0.2	-0.9	3.0
Standing height	0.4	4.2	14.6	1.1	-2.2	0.9	0.7	0.7	-3.8	2.7
Length of working week for main job	2.5	2.7	5.4	1.4	1.9	0.7	1.5	1.2	-2.3	2.0
Exposure to tobacco smoke at home	0.9	1.1	3.0	0.4	0.5	0.5	1.1	0.7	-1.4	-1.7
Breastfed as a baby	0.8	1.0	3.3	-0.9	-1.8	0.6	-0.5	-0.4	1.3	0.8
Tense / ‘highly strung’	0.9	1.6	5.1	0.2	0.2	1.5	0.6	0.1	-1.8	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.3	0.2	1.8	-0.1	1.0	0.3	-0.0	-1.2
Hair/balding pattern: Pattern 4	0.8	2.0	5.2	1.2	2.3	0.2	0.3	1.6	-2.0	0.9
Birth weight of first child	0.4	0.7	1.5	0.4	1.0	-1.1	0.3	0.4	-1.2	0.8
Peak expiratory flow (PEF)	0.1	0.3	0.8	-0.2	-0.9	-0.4	-0.9	-0.4	-0.4	0.5
Pulse wave reflection index	0.5	0.6	2.0	0.6	0.5	-1.4	-0.6	0.5	-0.9	0.1
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.7	-0.8	0.1	-0.7	-0.3	-0.7	-0.7	-1.3
Loud music exposure frequency	1.5	1.7	3.8	0.8	1.6	0.7	1.9	0.8	-1.5	-1.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	9.2	-0.4	-0.5	-0.1	-0.2	-0.3	-0.8	3.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.2	-0.4	-0.8	-0.8	-1.5	-0.7	0.6	-1.4
Blood clot in the leg (DVT)	0.6	0.8	1.7	1.3	1.1	-0.0	0.4	1.3	-0.2	1.1
Medication: Paracetamol	0.3	0.5	2.5	-0.3	0.8	0.5	0.3	-0.2	0.3	-1.6
Headache pain in last month	0.4	0.7	1.4	-0.7	0.3	0.7	0.9	-0.8	-1.2	1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	4.3	-0.6	-1.3	0.2	-0.8	-0.8	-0.7	2.1
Glaucoma (self-reported)	12.8	15.0	29.1	-4.9	-4.9	-0.6	-5.4	-5.0	1.4	0.9
Gout (self-reported)	0.1	0.1	0.4	-0.2	0.6	-0.1	-0.1	-0.2	0.1	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.3	0.2	-0.1	-0.0	0.1	0.1	1.5	-0.7
Medication: Amlodipine	0.6	0.8	2.7	-0.9	-0.7	-0.3	-1.1	-0.6	-0.2	-1.6
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.9	-0.6	-0.3	-0.1	-0.7	-0.4	1.9	2.2
Birth weight	0.3	0.6	1.6	-0.5	-1.3	1.1	0.1	-0.7	0.2	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.0	0.5	-0.4	-0.8	0.2	0.3	-0.2	-1.0
High blood pressure (siblings)	0.3	0.5	1.9	0.4	0.3	0.6	-0.4	0.3	-1.4	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	5.6	0.6	-2.4	1.3	0.9	0.1	0.2	0.5
Body fat percentage	0.4	1.7	4.1	-0.1	1.7	1.8	2.0	-0.0	-1.1	-0.5
Leg fat percentage (right)	0.4	1.3	3.9	0.1	2.0	1.0	1.8	0.2	0.1	-0.9
Arm fat-free mass (right)	0.3	1.4	6.5	-0.1	-0.2	0.5	1.7	-0.1	0.1	2.5
Exposure to tobacco smoke outside home	0.6	0.8	2.2	-0.5	-0.1	1.0	0.8	-0.4	-1.5	-1.0
Comparative body size at age 10	0.8	2.2	5.1	-2.1	-0.3	-0.2	-0.9	-1.9	2.3	1.1
Number of full brothers	0.6	0.8	3.6	-0.0	-1.1	-0.8	-0.1	0.1	0.1	-1.9
Worry too long after embarrassment	0.6	1.0	3.9	0.2	-0.5	1.6	-2.0	-0.1	0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.1	-0.1	0.1	-0.0	0.2	0.3	-0.3
Wheeze or whistling in the chest in last year	0.4	0.8	2.3	0.3	0.1	1.5	0.1	0.2	-0.8	1.5
Number of children fathered	1.3	1.5	3.8	1.0	2.0	-0.1	0.8	1.4	-1.2	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	-0.6	-0.5	0.2	-0.7	-0.7	-0.1	-0.9
Age at first live birth	2.1	3.7	20.3	-0.7	-1.4	-0.3	-1.4	-0.9	-0.8	4.5
Pulse wave peak to peak time	1.0	1.1	2.9	-0.7	-1.7	0.8	-0.4	-0.8	0.7	1.7
Health satisfaction	0.2	0.3	0.6	-0.6	-0.3	0.8	0.6	-0.4	0.3	-0.7
Shortness of breath walking on level ground	1.3	1.6	3.9	0.5	2.0	1.9	1.3	0.6	-1.0	-0.8
Qualifications: College or University degree	0.2	0.7	3.7	0.3	-0.7	-0.8	-0.5	-0.1	0.1	1.9
Eye problems/disorders: None of the above	2.3	2.6	6.2	2.4	1.5	0.1	1.7	2.5	-1.0	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	0.2	-0.5	0.7	0.3	0.3	-0.4	-0.9
Emphysema/chronic bronchitis	0.6	0.6	1.6	-1.2	-0.0	0.6	0.9	-0.9	0.8	0.5
Medication for pain relief, constipation, heartburn	1.8	3.1	7.7	-0.2	-2.0	-2.1	-2.3	-0.3	0.2	2.8
Neck or shoulder pain in last month	1.0	1.5	4.3	-2.1	0.5	-0.0	0.1	-1.9	1.2	-0.7
Medication: Blood pressure	0.6	1.1	6.1	0.3	0.2	0.9	0.5	0.4	-0.2	-2.5
Angina (self-reported)	0.7	1.0	5.0	-0.4	0.0	-0.5	-0.2	-0.0	-1.1	-2.2
Migraine (self-reported)	0.3	0.4	1.4	-0.3	-0.4	-0.0	-1.0	-0.4	-0.1	1.2
Medication: Ibuprofen	2.1	2.5	6.4	-2.5	-1.2	1.7	0.3	-2.4	-0.9	-0.6
Medication: Allopurinol	0.2	0.2	0.8	0.0	0.2	-0.6	-0.5	-0.1	-0.9	-0.3
Medication: Omeprazole	1.2	1.4	4.2	-0.5	1.8	0.8	2.1	-0.2	-0.2	-1.2
Medication: Seretide 50 evohaler	1.0	1.1	2.5	-0.8	-1.6	-0.3	-1.5	-0.9	-1.1	0.5
Mean time to correctly identify matches	0.6	1.2	3.5	0.6	1.6	0.2	1.1	0.6	0.5	1.9
Heart disease (mother)	0.3	0.4	1.9	-0.3	-0.7	-0.3	-0.4	-0.5	0.2	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.8	-0.3	0.9	1.0	0.2	-0.3	-1.1	-1.7
Whole body fat mass	0.5	1.9	5.6	0.1	1.4	2.0	2.4	0.1	-1.4	0.4
Leg fat mass (right)	0.4	1.5	5.1	0.3	1.6	1.6	2.3	0.3	-0.5	-0.0
Arm predicted mass (right)	0.3	1.5	7.0	-0.2	-0.4	0.7	1.7	-0.2	-0.1	2.6
Pulse rate, automated reading	0.6	1.8	7.0	-1.1	-1.2	0.6	-0.6	-1.2	-0.7	-2.6
Alcohol intake frequency.	1.1	2.5	8.3	0.4	2.3	1.0	2.9	0.3	-1.6	-0.2
Comparative height size at age 10	0.5	2.7	7.6	1.6	-1.2	0.9	1.1	1.3	-2.0	2.8
Number of full sisters	0.8	1.0	5.7	-0.3	-0.1	0.1	0.6	0.1	1.0	-2.4
Suffer from ‘nerves’	0.5	0.9	2.1	1.2	-0.7	0.9	0.2	1.1	0.2	-1.4
Overall health rating	0.5	1.0	3.8	-0.1	1.9	-0.9	0.8	0.1	0.4	-1.3
Chest pain or discomfort	0.6	0.9	3.8	-0.4	0.2	0.4	-0.2	-0.6	-1.9	-1.5
Had major operations	0.9	1.0	5.4	0.1	0.9	-0.3	0.5	0.4	2.3	-0.6
Age at last live birth	0.8	1.2	6.9	0.1	-0.4	-1.0	-0.6	-0.1	-0.4	2.6
Family relationship satisfaction	0.3	0.3	1.0	-0.8	-0.4	0.2	-0.3	-0.6	-1.0	0.2
Leg pain on walking	0.9	1.1	3.3	-0.4	1.8	0.6	1.6	-0.3	0.5	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.6	-1.6	-0.5	-0.0	-0.3	-1.4	0.0	-0.2
Commuting to job workplace: Car/motor vehicle	1.4	1.7	6.9	0.0	0.0	1.3	-0.1	0.2	1.7	-2.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.4	0.3	-0.4	-0.4	-1.5	0.1	0.2	-1.5
Medication: Aspirin	2.9	3.9	9.5	1.7	1.9	1.9	1.8	1.6	-1.4	-3.1
Supplements: Vitamin C	0.4	0.5	1.7	1.0	0.2	0.8	0.2	1.3	0.0	0.4
Knee pain experienced in last month	0.5	0.8	2.6	0.1	1.6	-0.6	0.7	0.3	1.1	-1.0
Hypertension (Self-reported)	0.3	0.9	3.0	0.3	1.5	-0.1	0.8	0.5	-0.3	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.6	-1.3	1.6	-0.9	1.1	-1.0	0.3	-0.9
Illnesses of father: Heart disease	0.9	1.2	5.2	0.7	1.1	-0.0	2.3	0.7	0.4	0.9
Illnesses of siblings: Diabetes	1.5	1.9	3.9	1.8	1.4	-0.5	0.1	2.0	1.7	1.0
Smoking status: Previous	0.5	0.8	2.1	-0.4	0.8	1.0	1.5	0.1	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.8	-0.3	-1.5	-1.4	-0.1	-0.6	-1.7	1.5
Whole body fat-free mass	0.3	1.8	8.3	0.2	-0.5	0.8	1.6	0.1	-0.9	2.9
Leg fat-free mass (right)	0.3	1.6	6.6	-0.3	-0.2	1.1	1.6	-0.3	-1.0	2.6
Arm fat percentage (left)	0.4	1.7	4.3	-0.2	1.7	1.9	2.1	-0.1	-1.1	-0.1
Average weekly red wine intake	1.3	1.9	5.8	-0.2	0.0	-2.2	-1.1	-0.3	2.4	1.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.7	0.1	0.0	1.2	0.1	-0.1	1.3	-0.3
Mood swings	0.3	0.5	1.5	0.1	1.2	0.7	1.0	0.1	-0.3	0.5
Loneliness, isolation	1.0	1.4	4.2	-2.0	-0.9	-0.1	-0.2	-1.9	-0.1	-1.1
Long-standing illness, disability or infirmity	0.5	0.8	1.5	-1.2	0.8	-1.0	-0.8	-1.0	0.7	-0.6
Ever had bowel cancer screening	1.6	1.9	6.8	-0.6	-0.3	-2.6	-1.1	-0.8	-0.1	-2.0
Diabetes diagnosed by doctor	0.6	1.0	2.4	0.7	0.7	0.9	0.1	1.0	1.2	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.9	0.8	0.7	0.1	1.2	0.8	-1.4	-0.2
Friendships satisfaction	0.4	0.5	1.4	-0.5	-0.3	0.6	-0.4	-0.4	1.2	0.9
Qualifications: nursing, teaching	1.0	1.6	8.0	-0.5	-0.4	-1.1	-1.0	-0.6	0.1	2.8
Commuting to job workplace: Walk	0.2	0.2	1.1	0.4	0.0	-0.5	0.4	0.2	-1.0	0.1
Eye problems/disorders: Cataract	0.4	0.5	1.2	-0.2	1.1	-0.2	1.1	0.0	1.0	0.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.3	-1.0	1.0	1.5	0.1	-1.1	0.5	-1.1
Medication for cholesterol	0.3	0.4	0.8	0.9	0.4	0.7	0.3	0.8	-0.5	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	0.9	-0.1	-0.4	0.3	0.8	0.8	1.2
Back pain experienced in last month	3.9	5.6	12.3	2.2	3.5	2.5	3.0	2.2	0.3	-1.5
Mineral and other dietary supplements	0.2	0.2	0.9	0.4	0.1	0.2	0.5	0.1	-0.4	1.0
Breast cancer (self-reported)	0.3	0.4	1.8	0.3	-0.0	0.2	1.4	0.3	0.3	-0.8
Asthma (self-reported)	0.5	1.1	6.5	0.2	0.4	0.3	-0.8	-0.0	0.3	2.5
Osteoporosis (self-reported)	0.8	1.0	3.2	-0.5	-0.5	-1.5	-0.9	-0.3	-0.3	1.8
Osteoarthritis (self-reported)	1.4	1.8	6.0	0.6	1.3	0.8	-0.8	0.7	1.6	-2.4
Medication: Aspirin	2.8	3.7	10.4	1.5	2.0	1.8	1.1	1.5	-1.6	-3.2
Medication: Gliclazide	0.3	0.4	0.8	0.6	-0.9	0.8	0.5	0.6	-0.3	-0.2
Illnesses of father: None of the above (group 1)	0.8	1.0	5.4	0.3	-0.7	-0.0	-0.8	0.2	-2.3	0.6
Smoking status: Current	0.6	0.9	2.6	-0.6	0.9	-1.5	1.6	-0.2	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	6.9	0.6	-0.1	2.6	0.4	0.4	1.4	-1.5
Whole body water mass	0.3	1.8	8.6	0.1	-0.6	0.7	1.5	0.0	-0.8	2.9
Leg predicted mass (right)	0.3	1.6	6.2	-0.2	-0.1	1.1	1.6	-0.2	-0.9	2.5
Arm fat mass (left)	0.3	1.4	3.6	-0.4	1.1	1.8	1.9	-0.4	-1.0	0.6
Number of self-reported non-cancer illnesses	0.8	1.4	2.7	-1.3	1.4	-0.3	1.0	-1.1	1.1	-1.6
Average weekly champagne plus white wine intake	1.1	1.6	5.5	-0.4	-0.5	1.7	0.8	-0.5	1.2	2.3
Miserableness	1.4	2.4	5.4	-2.3	-1.3	0.6	-1.4	-2.2	-0.7	-1.4
Guilty feelings	0.7	1.0	2.5	-0.7	-1.6	0.1	-1.1	-0.7	0.9	1.2
Wears glasses or contact lenses	0.6	0.7	1.9	0.3	0.0	1.4	-0.1	0.4	1.1	-1.3
Ever taken oral contraceptive pill	0.6	0.6	2.8	-0.3	-1.7	0.1	-0.8	-0.7	-0.4	-0.4
Hearing aid user	1.2	1.4	3.1	1.3	1.5	0.4	-0.5	1.4	-1.8	0.1
Mother’s age at death	2.4	3.0	6.2	-2.1	-1.6	-1.5	-1.4	-1.9	-0.6	2.5
Financial situation satisfaction	0.9	1.1	6.2	-0.3	0.1	-1.0	0.5	-0.4	-2.5	-0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	-0.6	0.5	-1.0	-0.7	-0.5	0.6	-0.9
Commuting to job workplace: Public transport	0.4	0.5	2.1	-0.3	-0.4	-0.9	-0.3	-0.3	0.3	1.5
Eye problems/disorders: Glaucoma	10.9	12.9	25.1	-4.3	-5.0	0.1	-4.8	-4.5	0.9	1.6
Medication: Blood pressure	0.3	0.6	1.1	0.8	1.0	-0.5	-0.1	1.0	-0.2	-1.0
Pain type(s) experienced in last month: Hip pain	1.5	1.9	8.4	-0.2	2.9	0.2	2.1	0.0	-0.0	0.0
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	0.3	0.8	0.2	0.4	0.6	-0.3	-0.9
High cholesterol (Self-reported)	1.1	1.9	3.1	1.6	1.3	1.2	1.5	1.8	1.3	-0.5
Medication: Bendroflumethiazide	0.4	0.6	1.5	-0.9	-0.6	0.6	-0.6	-0.9	-0.3	-1.2
Medication: Paracetamol	0.3	0.5	2.3	-0.7	0.3	0.4	0.1	-0.6	0.4	-1.5
Medication: Lisinopril	1.4	1.8	4.7	-0.3	-0.7	-2.2	-1.5	-0.3	1.2	-1.9
Medication: Atorvastatin	0.4	0.5	2.7	0.1	-0.2	-0.4	0.1	0.3	1.7	-0.5
Illnesses of father: High blood pressure	0.6	0.7	2.7	-0.9	-0.6	0.0	0.0	-1.0	0.0	-1.6
Alcohol drinker status: Never	0.5	0.6	1.1	-0.8	1.1	1.0	0.7	-0.9	-0.4	0.0
Ever smoked	0.4	0.7	2.5	0.2	0.2	0.5	1.6	0.6	-1.0	-0.6
Basal metabolic rate	0.3	1.7	6.2	0.2	-0.2	1.0	1.8	0.1	-1.1	2.5
Leg fat percentage (left)	0.4	1.3	3.7	-0.2	1.9	1.2	1.7	-0.1	-0.1	-0.8
Arm fat-free mass (left)	0.2	1.0	4.8	-0.2	-0.7	0.4	1.1	-0.2	-0.1	2.2
Number of operations (self-reported)	0.2	0.4	0.9	-0.3	0.7	-0.9	-0.8	-0.2	0.0	-0.6
Average weekly beer plus cider intake	1.6	2.3	5.5	1.0	2.1	1.0	2.3	0.9	0.7	-1.7
Irritability	0.9	1.5	4.5	0.9	1.5	1.6	2.1	0.9	0.0	-0.4
Risk taking	0.3	0.4	0.7	-0.8	0.6	0.9	0.6	-0.6	0.2	0.4
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.3	1.5	1.5	0.4	0.5	1.5	0.4	-1.0
Fractured/broken bones in last 5 years	1.6	2.1	4.1	-2.0	-2.0	-1.2	-1.3	-1.6	-0.4	0.8
Age started oral contraceptive pill	0.5	0.6	1.8	1.0	-0.2	-0.6	-0.4	0.8	1.3	-0.5
Diastolic blood pressure, automated reading	0.6	1.9	2.6	-1.6	-1.6	-1.4	-1.0	-1.6	0.9	-1.2
Ever depressed for a whole week	0.9	1.1	3.1	-0.9	1.8	-0.4	0.3	-0.9	-0.2	-1.6
Unable to work because of sickness or disability	0.2	0.3	0.9	-0.9	-0.1	-0.5	-0.3	-0.9	0.3	-0.4
Commuting to job workplace: Cycle	0.6	0.8	1.6	-0.7	-1.0	-0.7	-0.6	-0.6	-1.2	1.1
Myopia	0.8	1.2	3.4	0.4	-1.8	0.5	-1.1	0.5	-0.3	-1.8
Vascular/heart problems diagnosed by doctor	0.6	1.7	5.7	-0.1	-1.9	0.2	-1.4	-0.5	0.5	2.4
Cholesterol lowering medication	0.7	1.0	2.9	1.0	1.0	0.0	1.7	1.2	0.6	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	4.1	-0.4	1.6	0.7	2.0	-0.1	-0.0	-1.4
Pain experienced in last month	0.9	1.5	4.2	0.6	-2.0	0.1	-1.6	0.5	-0.4	1.7
Supplements: Calcium	1.3	1.4	3.8	-0.9	-1.9	-0.7	-0.9	-0.8	-1.1	1.5
Basal cell carcinoma (self-reported)	0.8	0.9	2.1	0.7	1.1	0.1	1.1	0.8	-0.9	-1.5
Heart attack/myocardial infarction (self-reported)	1.7	2.2	10.9	-0.1	0.5	-0.9	1.2	0.2	-1.3	-3.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	1.1	0.6	0.1	0.1	1.1	-0.1	0.9
Heart disease (siblings)	0.5	0.6	1.1	-0.9	0.5	-1.1	-0.3	-1.0	0.7	-0.9
Alcohol drinker status: Previous	1.1	1.2	6.0	0.2	0.4	0.0	2.4	0.2	0.6	1.4
Pack years of smoking	0.6	0.8	2.2	1.0	-0.7	-0.4	-0.8	1.1	0.4	-1.5
Impedance of whole body	0.2	1.3	5.6	0.1	-0.5	0.1	-1.0	-0.2	-2.4	-1.4
Leg fat mass (left)	0.4	1.4	4.7	0.0	1.4	1.6	2.2	0.1	-0.8	0.0
Arm predicted mass (left)	0.3	1.4	7.3	-0.1	-0.6	0.5	1.2	-0.2	-0.2	2.7