Hub : Genes

ZBTB45

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1200 0.0400 5.2e-05 0.039 NA 0.071 NA 0.076 3.4e-03 NA 9.4e-05 NA 5.2e-05
2 GTEx Brain Caudate basal ganglia 0.2640 0.0980 5.3e-03 -0.009 NA 0.003 NA -0.010 7.3e-01 NA 2.6e-01 NA 9.0e-01
3 TCGA Breast Invasive Carcinoma 0.0201 0.0115 3.1e-03 0.009 0.011 0.011 NA 0.008 5.7e-03 0.00210 1.9e-03 NA 8.8e-03
4 TCGA Lung Squamous Cell Carcinoma 0.0633 0.0338 2.9e-05 0.057 0.034 0.036 NA 0.052 4.2e-07 0.00009 6.0e-05 NA 1.3e-06
5 TCGA Soft Tissue Sarcoma 0.1410 0.1010 6.9e-03 0.005 0.001 -0.005 NA -0.001 1.5e-01 0.26000 1.0e+00 NA 3.8e-01
6 TCGA Uterine Corpus Endometrial Carcinoma 0.1290 0.0710 8.8e-03 0.018 0.070 0.042 NA 0.026 1.0e-01 0.00540 2.6e-02 NA 6.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 4.0 6.3 16.7 4.1 0.0 -2.2 -2.2 -1.2 -3.1
Bipolar Disorder or Schizophrenia 1.8 4.4 8.0 2.8 0.0 -1.7 -2.5 -1.9 -2.4
Depressed Affect (Nagel 2018) 2.3 4.9 14.1 -2.3 0.0 0.1 1.6 2.7 3.8
Depression (Nagel 2018) 0.2 0.3 1.4 0.3 0.0 0.0 0.5 1.2 0.6
Intelligence (Savage-Jansen 2018) 2.6 7.9 20.8 4.6 0.0 -4.3 -1.9 1.6 -1.5
Neuroticism (Nagel 2018) 2.1 4.9 13.3 -1.0 0.0 -1.1 1.3 3.6 3.5
Schizophrenia (2018) 0.4 0.8 2.2 0.4 0.0 -0.4 -1.4 -1.5 -0.6
Schizophrenia vs Biploar Disorder 0.4 0.5 1.4 -1.2 0.0 0.5 0.6 0.3 1.0
Worry (Nagel 2018) 1.3 2.8 9.5 -0.3 0.0 -1.1 0.8 3.1 2.3
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 -0.3 0.0 -0.1 -0.1 -0.1 0.3
Alzheimer’s Disease (in father) 0.3 0.4 0.8 0.8 0.0 -0.9 0.0 0.7 0.4
Alzheimer’s Disease (including proxy) 0.1 0.1 0.4 0.1 0.0 -0.6 -0.2 0.1 0.5
Crohns Disease (2017) 2.6 5.8 10.2 1.9 0.0 -1.6 -2.9 -3.2 -3.2
Irritable Bowel Disease (IBD) 2.1 4.9 10.5 1.3 0.0 -1.4 -2.9 -3.2 -2.6
Ulcerative Colitis (UC) 0.9 1.8 4.1 0.6 0.0 -1.2 -2.0 -1.9 -1.0
Major Depression (MDD) 3.6 4.3 7.2 2.7 0.0 -2.7 -2.3 -1.3 -2.2
Reaction Time 0.5 1.0 3.7 -1.9 0.0 0.7 -0.2 -0.8 1.0
Verbal and Numeric Reasoning (VNR) 1.6 3.9 10.9 3.3 0.0 -2.7 -0.9 1.5 -1.4
Breast Cancer 1.4 3.3 6.1 2.5 0.0 -2.4 -2.1 -0.9 -1.6
Ovarian Cancer 0.4 0.5 1.5 0.7 0.0 -0.9 0.2 1.2 0.3
Prostate Cancer 0.1 0.1 0.3 0.3 0.0 -0.5 -0.2 0.4 -0.0
Age at First Birth 0.2 0.3 0.9 -0.8 0.0 0.1 0.6 0.4 1.0
Bipolar Disorder (2011) 0.6 0.6 3.7 1.9 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.6 1.6 0.4 0.0 1.3 0.2 -0.5 -1.2
Coronary Artery Disease (CAD) 1.4 1.6 3.8 0.7 0.0 -0.3 -1.5 -1.8 -1.9
Crohns Disease (2012) 1.5 2.5 5.3 1.1 0.0 -0.5 -1.8 -2.3 -2.2
Mean Putamen Volume 0.5 0.6 2.2 -1.5 0.0 0.8 0.4 -0.3 0.8
Fasting Glucose 0.4 0.4 1.0 0.1 0.0 0.8 -0.3 -0.9 -1.0
HbA1C 0.1 0.1 0.4 0.7 0.0 0.0 -0.4 -0.1 -0.3
HDL Cholesterol 0.3 0.4 1.1 -1.1 0.0 -0.7 -0.1 0.1 1.0
LDL Cholesterol 0.3 0.5 1.3 -0.2 0.0 0.9 1.1 0.8 0.5
Lupus 0.6 1.0 2.6 -0.9 0.0 1.4 -0.4 -1.6 0.5
Neuroticism (2016) 0.6 0.9 2.6 -0.7 0.0 -0.1 0.9 1.6 1.2
Primary Biliary Cirrhosis 0.4 0.6 2.1 0.0 0.0 0.3 1.1 1.5 0.4
Rheumatoid Arthritis 0.5 0.7 1.0 -0.9 0.0 0.9 0.9 0.8 1.0
Schizophrenia (2014) 0.6 1.2 2.6 1.1 0.0 -0.8 -1.6 -1.5 -0.8
Triglycerides 0.3 0.5 1.7 -0.0 0.0 1.3 0.9 0.3 -0.6
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.1 -0.6 0.0 0.5 0.1 0.3 1.1
Ulcerative Colitis 0.5 0.7 2.2 -0.8 0.0 -0.2 -1.0 -1.5 0.6
Blood Eosinophil Count 0.7 5.6 13.0 -2.8 0.0 1.7 2.2 2.4 3.6
Blood Platelet Count 3.5 40.7 74.0 -5.9 0.0 5.1 8.1 8.6 6.6
Blood Red Count 0.1 1.2 4.2 0.8 0.0 0.3 1.1 2.1 -0.8
Blood White Count 0.6 4.4 12.0 -1.8 0.0 0.6 2.4 3.5 2.2
Heel T-Score 1.8 14.5 30.6 -5.3 0.0 5.5 4.2 1.2 3.0
BMI 0.1 0.6 2.5 0.4 0.0 -0.7 0.4 1.6 0.6
Height 0.3 5.1 11.6 -1.0 0.0 1.9 3.4 3.3 1.9
Waist Hip Ratio (WHR) 0.1 0.5 1.7 -0.6 0.0 -0.2 -1.0 -1.3 0.2
Systolic Blood Pressure 0.1 0.5 1.5 0.5 0.0 0.3 1.0 1.2 0.5
Smoking Status 0.1 0.3 0.8 0.5 0.0 -0.3 0.2 0.6 -0.9
Allergy or Eczema 0.5 1.2 2.3 0.7 0.0 -1.4 -1.5 -1.1 -1.1
Cardiovascular Disease 0.2 0.8 2.4 1.5 0.0 -1.2 -0.4 0.8 0.1
Hypothyroidism (self reported) 0.7 1.6 4.2 -2.0 0.0 2.0 0.9 -0.3 0.9
Respiratory disease 0.2 0.5 1.3 -1.1 0.0 -0.7 -0.4 0.1 1.1
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.9 0.1 0.0 -0.4 -0.9 -0.9 -0.5
Lung FEV1/FVC ratio 0.1 0.5 1.9 -0.8 0.0 -0.5 -0.1 0.6 1.4
Lung FVC 0.0 0.2 0.4 -0.3 0.0 0.7 0.3 -0.3 -0.5
Neuroticism 2.2 5.4 13.1 -1.8 0.0 -0.4 1.8 3.6 3.5
Chronotype (morning person) 2.2 5.0 15.9 0.8 0.0 -1.1 -2.9 -4.0 -2.0
Hair Pigment 0.2 6.7 13.2 -3.0 0.0 3.6 3.1 1.5 2.5
Tanning 0.1 0.7 1.7 -1.3 0.0 -0.9 -0.7 -0.2 1.2
Hand grip strength (left) 1.3 3.5 10.7 -2.0 0.0 3.3 2.2 0.4 0.9
Number of treatments/medications taken 0.5 0.9 2.7 1.1 0.0 -1.6 -0.8 0.9 0.3
Average weekly spirits intake 0.2 0.2 0.6 -0.4 0.0 0.8 0.1 -0.5 -0.3
Sensitivity / hurt feelings 1.3 2.2 6.2 1.5 0.0 -1.7 0.4 2.5 1.4
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.5 0.2 0.0 -0.3 0.1 0.7 0.2
Hearing difficulty/problems: Yes 5.1 7.8 14.0 -3.7 0.0 2.5 3.2 2.6 3.2
Relative age of first facial hair 1.3 2.8 9.9 1.9 0.0 -1.3 1.1 3.1 0.5
Other serious medical condition/disability diagnosed by doctor 5.3 6.9 12.7 -3.6 0.0 2.3 2.8 2.0 3.4
Ever used hormone-replacement therapy (HRT) 0.9 1.2 3.7 1.5 0.0 -1.9 -1.1 0.1 -0.3
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 -0.8 0.0 0.2 -0.1 -0.1 0.7
Systolic blood pressure, automated reading 0.2 0.5 1.8 0.3 0.0 0.2 0.9 1.4 0.3
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.5 1.2 0.0 -1.3 -1.6 -1.3 -0.6
Angina 2.0 2.6 6.3 1.1 0.0 -0.5 -1.9 -2.5 -2.1
Medication for hormone replacement therapy 2.8 3.1 6.7 2.6 0.0 -1.5 -1.8 -1.5 -2.1
Vitamin and mineral supplements 3.7 5.0 11.0 -3.2 0.0 3.3 2.6 0.8 1.3
Supplements: Zinc 5.5 5.9 12.4 3.5 0.0 -2.5 -2.6 -1.8 -2.7
Medication: Co-codamol 0.6 0.7 1.6 1.1 0.0 -1.3 -0.8 0.5 -0.7
Medication: Metformin 0.3 0.4 1.3 0.8 0.0 -1.2 -0.6 0.1 0.0
Diabetes (father) 3.2 4.0 7.7 2.2 0.0 -1.7 -2.2 -1.9 -2.8
Diabetes (mother) 1.0 1.2 3.7 1.9 0.0 -1.1 -0.9 0.1 -1.3
Severe depression (siblings) 5.3 5.9 8.9 2.5 0.0 -2.3 -3.0 -2.8 -2.7
Pack years adult smoking proportion 0.5 0.7 2.1 -1.2 0.0 1.4 0.5 -0.4 0.5
Impedance of leg (right) 0.0 0.2 0.6 -0.8 0.0 0.3 0.5 0.1 0.2
Leg fat-free mass (left) 0.1 0.7 2.0 1.4 0.0 -0.6 0.2 1.3 0.1
Trunk fat percentage 0.7 2.9 12.4 0.3 0.0 -1.0 1.4 3.5 1.5
Hand grip strength (right) 1.2 3.4 7.1 -1.9 0.0 2.7 2.6 1.2 1.2
Townsend deprivation index at recruitment 0.1 0.1 0.4 -0.5 0.0 0.3 -0.3 -0.6 0.0
Current tobacco smoking 0.5 0.8 2.2 -1.5 0.0 1.3 1.0 0.1 0.3
Average weekly fortified wine intake 0.6 0.7 2.9 0.6 0.0 -0.7 0.8 1.7 -0.1
Maternal smoking around birth 0.1 0.2 0.8 0.9 0.0 -0.1 0.0 0.4 -0.1
Fed-up feelings 0.6 1.0 3.9 -0.9 0.0 0.0 0.4 1.1 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.9 1.4 0.0 -0.9 -0.5 0.1 -0.3
Relative age voice broke 1.3 2.0 8.0 1.0 0.0 -0.7 1.3 2.8 0.9
Taking other prescription medications 0.3 0.5 1.2 0.4 0.0 -0.9 -1.1 -0.6 -0.5
Age when periods started (menarche) 1.6 3.8 16.3 1.0 0.0 -1.1 1.6 4.0 1.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.9 -0.3 0.0 -0.2 0.0 0.5 1.0
Heel bone mineral density (BMD) T-score, automated (left) 2.2 5.0 10.8 -2.0 0.0 3.3 3.0 1.7 1.8
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.1 0.0 0.1 0.3 0.3 -0.5
Qualifications: CSEs or equivalent 3.5 4.6 9.3 1.3 0.0 -1.4 -2.7 -3.0 -2.7
Serious illness, injury or assault to yourself 1.5 1.8 6.2 -2.5 0.0 0.7 0.2 -0.3 1.9
High blood pressure 0.6 1.6 4.0 2.0 0.0 -2.0 -1.2 0.5 -0.4
Hayfever, allergic rhinitis or eczema 0.5 1.2 1.7 0.9 0.0 -1.2 -1.3 -1.1 -1.3
Multivitamins +/- minerals 3.0 3.9 8.9 2.3 0.0 -3.0 -2.5 -1.2 -1.2
Stomach or abdominal pain in last month 2.3 2.9 8.1 2.9 0.0 -1.9 -1.2 0.1 -2.0
Supplements: Glucosamine 1.1 1.5 4.5 1.8 0.0 -2.1 -1.0 0.2 -0.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.9 -0.1 0.0 -0.9 -0.1 0.4 -0.1
Medication: Atenolol 1.5 1.9 3.8 2.0 0.0 -1.1 -1.5 -1.0 -1.8
Medication: Levothyroxine sodium 1.1 1.8 4.9 -2.2 0.0 1.3 1.4 0.9 1.2
Sitting height 0.2 1.5 4.0 -0.6 0.0 1.4 2.0 1.4 0.6
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.0 0.0 -0.4 0.2 0.3 0.4
High blood pressure (mother) 3.2 4.5 8.1 2.4 0.0 -2.8 -2.7 -1.4 -2.0
Body mass index (BMI) 0.1 0.5 2.1 0.5 0.0 -0.6 0.1 1.4 0.1
Impedance of leg (left) 0.1 0.4 1.4 -1.2 0.0 0.6 0.7 0.2 0.4
Leg predicted mass (left) 0.1 0.6 2.0 1.4 0.0 -0.5 0.2 1.2 0.0
Trunk fat mass 0.6 2.6 11.2 0.3 0.0 -0.7 1.4 3.3 1.4
Waist circumference 0.3 0.9 3.1 0.6 0.0 -1.0 0.2 1.8 1.0
Number of incorrect matches in round 1.0 1.7 4.0 -2.0 0.0 1.5 0.6 -0.3 1.9
Past tobacco smoking 1.4 2.5 6.4 -2.2 0.0 2.5 1.5 0.0 1.4
Alcohol usually taken with meals 0.4 0.7 1.4 -1.0 0.0 0.0 -0.8 -1.2 0.9
Nervous feelings 1.7 3.2 8.2 -1.2 0.0 -0.5 1.2 2.8 2.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 3.0 0.2 0.0 -1.3 0.4 1.7 0.9
Hearing difficulty/problems with background noise 2.2 3.4 8.6 -1.4 0.0 -0.2 1.6 2.9 2.8
Hair/balding pattern: Pattern 2 1.8 2.2 3.7 1.9 0.0 -1.9 -1.4 -1.0 -1.8
Had menopause 0.7 0.9 1.8 -1.3 0.0 1.4 1.0 0.4 0.9
Had other major operations 0.4 0.5 2.0 0.6 0.0 -0.1 0.8 1.4 -0.4
Forced vital capacity (FVC) 0.2 0.9 1.8 1.4 0.0 0.0 1.1 1.1 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 4.4 -1.9 0.0 2.1 2.1 1.3 1.9
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.1 0.3 0.0 -0.4 -0.4 -0.2 0.1
Qualifications: None of the above 0.3 0.7 2.3 -1.5 0.0 0.4 0.2 0.1 1.3
Financial difficulties in last 2 years 0.3 0.4 1.6 -1.3 0.0 0.6 -0.2 -0.3 0.5
Mouth/teeth dental problems 0.2 0.4 0.9 -0.8 0.0 0.4 1.0 0.7 0.4
Heart attack 0.1 0.2 0.6 -0.1 0.0 0.4 -0.5 -0.7 -0.3
Allergy 0.7 1.6 3.0 -0.7 0.0 1.1 1.7 1.6 1.5
Pain all over the body in last month 2.3 2.5 4.5 1.9 0.0 -1.8 -1.6 -1.1 -2.1
Diabetes (self-reported) 0.9 1.3 2.2 1.0 0.0 -1.1 -1.5 -1.4 -1.3
Hayfever/allergic rhinitis (self-reported) 0.3 0.5 0.9 0.9 0.0 -0.7 -1.0 -0.6 -0.4
Medication: Ramipril 1.3 1.7 3.7 1.5 0.0 -1.9 -1.7 -0.5 -1.1
Medication: Simvastatin 0.6 0.9 3.1 -1.0 0.0 0.5 0.9 0.8 1.8
Fluid intelligence score 1.4 3.0 9.0 3.0 0.0 -2.4 -0.9 1.1 -1.2
Illnesses of siblings 0.4 0.5 1.8 -0.2 0.0 1.4 0.9 -0.3 -0.6
Neuroticism score 2.3 4.7 12.0 -1.6 0.0 -0.4 1.7 3.3 3.5
Weight 0.2 1.2 5.5 0.5 0.0 -0.3 1.0 2.3 0.7
Impedance of arm (right) 0.2 1.0 3.7 1.1 0.0 -1.9 -0.2 1.1 0.4
Arm fat percentage (right) 0.4 1.5 6.0 0.6 0.0 -1.3 0.4 2.4 0.9
Trunk fat-free mass 0.1 0.3 1.1 -0.1 0.0 1.1 0.8 0.4 0.2
Hip circumference 0.3 1.4 5.2 1.2 0.0 -1.2 0.5 2.3 0.2
Time employed in main current job 0.7 0.8 3.3 -0.7 0.0 -0.7 -0.4 0.5 1.8
Alcohol intake versus 10 years previously 0.2 0.3 0.8 0.1 0.0 -0.4 -0.9 -0.8 -0.4
Father’s age at death 0.6 0.8 1.4 -1.0 0.0 1.2 1.1 0.8 0.7
Worrier / anxious feelings 1.1 2.0 5.4 -0.5 0.0 -1.1 0.6 2.2 2.3
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.7 -0.7 0.0 -0.9 0.1 1.5 1.6
Falls in the last year 0.2 0.3 0.6 -0.6 0.0 0.7 0.6 0.3 0.7
Hair/balding pattern: Pattern 3 0.2 0.4 1.3 -0.3 0.0 -0.6 -0.1 0.7 1.1
Number of live births 0.2 0.3 0.9 -0.5 0.0 0.1 0.7 0.9 0.5
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.4 0.8 0.0 0.1 1.1 1.2 -0.5
Pulse rate 0.5 0.8 2.1 -1.0 0.0 0.6 1.4 1.2 0.2
Happiness 0.4 0.5 1.9 -0.1 0.0 0.2 -0.7 -1.4 -0.9
Noisy workplace 0.1 0.1 0.2 -0.3 0.0 0.4 0.5 0.0 0.2
Qualifications: A levels/AS levels or equivalent 0.6 1.2 3.1 1.8 0.0 -1.1 0.0 0.8 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 -0.3 0.0 0.8 0.5 0.4 -0.3
Mouth/teeth dental problems: Dentures 0.2 0.3 0.8 0.4 0.0 0.6 -0.4 -0.9 -0.8
Asthma 0.3 0.6 1.5 0.1 0.0 -0.7 -1.2 -1.2 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 5.2 0.4 0.0 -2.3 -2.2 -1.1 -0.3
Medication: Cholesterol lowering 0.9 1.4 3.9 -1.0 0.0 1.1 1.1 0.9 2.0
Depression (self-reported) 1.1 1.3 3.4 1.7 0.0 -1.9 -0.6 1.0 -0.3
Medication: Lansoprazole 1.3 1.5 3.2 -1.8 0.0 1.5 1.6 0.9 0.6
Prospective memory result 0.4 0.5 1.4 0.0 0.0 -0.2 -1.1 -1.2 0.4
Lung cancer (father) 0.2 0.3 1.2 -0.3 0.0 1.1 0.2 -0.5 -0.1
Illnesses of mother 1.8 2.2 4.6 -2.1 0.0 1.9 1.7 0.6 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 2.8 0.8 0.0 -0.4 1.0 1.7 0.2
Pulse wave Arterial Stiffness index 0.6 0.7 2.9 1.0 0.0 -0.1 -0.3 -0.6 -1.7
Impedance of arm (left) 0.2 1.1 3.8 0.4 0.0 -1.2 0.9 1.9 0.9
Arm fat mass (right) 0.2 1.0 4.5 0.6 0.0 -0.8 0.5 2.1 0.5
Trunk predicted mass 0.0 0.3 0.9 -0.0 0.0 1.0 0.7 0.3 0.1
Standing height 0.1 1.5 4.0 0.3 0.0 0.6 1.9 2.0 0.8
Length of working week for main job 1.4 1.6 4.6 0.5 0.0 -2.1 -2.0 -0.9 -0.1
Exposure to tobacco smoke at home 0.3 0.3 1.0 1.0 0.0 -0.7 -0.1 0.4 -0.5
Breastfed as a baby 1.2 1.5 4.0 -0.9 0.0 0.7 1.3 1.4 2.0
Tense / ‘highly strung’ 0.6 1.0 2.4 0.5 0.0 -1.4 -0.0 1.6 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.6 10.2 1.9 0.0 -3.2 -2.5 -0.8 -0.9
Hair/balding pattern: Pattern 4 1.1 2.7 6.4 -2.5 0.0 2.5 1.4 0.3 1.3
Birth weight of first child 2.1 3.8 7.5 -1.2 0.0 1.1 2.2 2.7 2.7
Peak expiratory flow (PEF) 0.4 1.0 2.3 1.5 0.0 -0.8 0.5 1.4 -0.9
Pulse wave reflection index 1.5 1.8 4.7 2.2 0.0 -1.2 -1.3 -1.0 -1.5
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.2 0.8 0.0 -2.1 -1.4 -0.4 -0.4
Loud music exposure frequency 0.7 0.8 1.9 0.2 0.0 -0.7 0.6 1.3 1.4
Qualifications: O levels/GCSEs or equivalent 1.9 3.0 7.9 2.8 0.0 -2.4 -1.4 0.2 -1.7
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.4 0.3 0.0 -0.6 -0.4 0.2 0.5
Blood clot in the leg (DVT) 0.1 0.1 0.5 -0.2 0.0 -0.3 0.3 0.7 -0.1
Medication: Paracetamol 1.3 2.1 4.2 1.0 0.0 -0.7 -1.9 -2.0 -1.8
Headache pain in last month 2.5 4.4 8.9 2.7 0.0 -3.0 -2.6 -0.9 -1.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.9 -0.1 0.0 -0.1 -0.4 -0.7 -1.0
Glaucoma (self-reported) 0.8 1.0 2.8 -1.7 0.0 0.1 -0.3 -0.6 1.6
Gout (self-reported) 1.4 2.0 5.5 1.9 0.0 -2.3 -1.5 -0.1 -0.7
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 4.9 -2.2 0.0 1.9 1.2 0.3 1.1
Medication: Amlodipine 1.6 2.2 8.0 -0.9 0.0 0.1 1.1 1.9 2.8
Medication: Ventolin 100micrograms inhaler 1.1 1.4 4.0 -0.1 0.0 0.7 -1.1 -2.0 -1.7
Birth weight 2.9 6.3 13.4 -2.8 0.0 1.2 2.5 2.9 3.7
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.1 0.8 0.0 -1.0 -0.8 -0.6 -0.6
High blood pressure (siblings) 0.7 1.0 2.6 -0.4 0.0 -1.2 0.0 1.4 1.6
Forced vital capacity (FVC), Best measure 0.2 0.8 2.5 0.9 0.0 -0.3 1.1 1.6 0.2
Body fat percentage 0.7 2.6 11.0 0.0 0.0 -0.8 1.2 3.3 1.6
Leg fat percentage (right) 0.4 1.6 5.5 -0.8 0.0 -0.2 0.9 2.4 1.6
Arm fat-free mass (right) 0.0 0.2 0.5 0.1 0.0 0.5 0.6 0.7 0.2
Exposure to tobacco smoke outside home 0.1 0.1 0.3 0.4 0.0 0.5 0.2 -0.2 -0.3
Comparative body size at age 10 0.3 0.9 3.0 0.8 0.0 -1.2 0.3 1.7 0.3
Number of full brothers 0.3 0.3 1.3 -1.1 0.0 0.7 0.3 -0.0 0.2
Worry too long after embarrassment 3.1 5.2 15.1 -0.6 0.0 -0.8 1.9 3.9 3.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.3 7.6 1.6 0.0 -2.8 -1.9 -0.4 -0.2
Wheeze or whistling in the chest in last year 1.6 2.8 5.8 1.0 0.0 -2.0 -2.4 -2.1 -1.3
Number of children fathered 0.6 0.6 1.4 -1.0 0.0 0.1 0.6 1.1 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.3 -0.6 0.0 0.2 0.2 0.1 0.5
Age at first live birth 0.0 0.1 0.4 0.1 0.0 -0.6 -0.0 0.1 0.0
Pulse wave peak to peak time 0.8 0.9 3.5 -1.1 0.0 0.2 0.4 0.8 1.9
Health satisfaction 0.3 0.4 1.6 -0.6 0.0 0.1 -0.7 -1.3 0.0
Shortness of breath walking on level ground 0.5 0.6 1.8 -1.0 0.0 0.3 0.5 0.8 1.4
Qualifications: College or University degree 0.2 0.8 2.2 -0.3 0.0 0.2 1.3 1.5 0.6
Eye problems/disorders: None of the above 1.2 1.3 4.8 -0.1 0.0 0.3 1.4 2.2 1.1
Mouth/teeth dental problems: Loose teeth 3.8 4.5 9.7 3.1 0.0 -1.6 -2.0 -1.7 -2.8
Emphysema/chronic bronchitis 0.3 0.3 1.6 -1.3 0.0 -0.2 0.0 -0.1 -0.3
Medication for pain relief, constipation, heartburn 0.5 0.8 2.0 0.7 0.0 0.7 1.4 1.2 -0.4
Neck or shoulder pain in last month 0.2 0.3 0.9 0.3 0.0 -0.2 -0.4 -0.7 -1.0
Medication: Blood pressure 0.2 0.4 1.7 1.3 0.0 -0.6 -0.6 -0.1 -0.4
Angina (self-reported) 1.6 2.1 5.1 1.0 0.0 -0.5 -1.8 -2.3 -1.8
Migraine (self-reported) 0.2 0.3 1.1 0.5 0.0 -1.1 -0.6 0.2 0.0
Medication: Ibuprofen 0.7 0.8 2.9 -0.1 0.0 -1.7 -1.3 -0.1 0.4
Medication: Allopurinol 2.1 2.7 7.1 2.1 0.0 -2.7 -2.0 -0.5 -0.8
Medication: Omeprazole 0.2 0.2 0.6 -0.8 0.0 0.5 0.6 0.3 0.3
Medication: Seretide 50 evohaler 0.3 0.4 1.1 0.3 0.0 0.2 -0.6 -0.8 -1.1
Mean time to correctly identify matches 1.9 3.6 10.4 -3.2 0.0 1.8 1.0 0.2 2.6
Heart disease (mother) 0.0 0.0 0.1 -0.0 0.0 0.1 0.2 0.3 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.6 0.8 0.0 0.0 -0.6 -0.5 -0.7
Whole body fat mass 0.5 2.2 9.2 0.1 0.0 -0.6 1.3 3.0 1.4
Leg fat mass (right) 0.3 1.1 5.1 0.0 0.0 -0.4 0.7 2.3 1.0
Arm predicted mass (right) 0.0 0.2 0.5 0.1 0.0 0.7 0.6 0.5 0.2
Pulse rate, automated reading 0.1 0.3 1.0 -0.2 0.0 -0.5 0.6 1.0 0.0
Alcohol intake frequency. 1.2 2.9 8.2 2.9 0.0 -1.5 -1.4 -0.5 -2.1
Comparative height size at age 10 0.2 0.9 3.1 -0.8 0.0 1.7 1.2 -0.1 0.6
Number of full sisters 0.3 0.4 1.1 -0.8 0.0 0.6 -0.3 -1.0 0.1
Suffer from ‘nerves’ 2.3 3.5 9.7 -0.8 0.0 -0.9 1.1 3.0 3.1
Overall health rating 0.1 0.3 1.0 -0.2 0.0 -1.0 -0.7 0.2 0.6
Chest pain or discomfort 1.0 1.4 2.7 1.1 0.0 -1.3 -1.6 -1.1 -1.3
Had major operations 0.1 0.1 0.4 -0.3 0.0 0.3 -0.3 -0.7 -0.1
Age at last live birth 0.3 0.4 0.8 0.4 0.0 -0.9 -0.7 -0.7 -0.5
Family relationship satisfaction 1.5 1.8 6.1 0.2 0.0 -0.2 -1.7 -2.5 -1.4
Leg pain on walking 1.3 1.7 2.9 -1.5 0.0 1.1 1.7 1.4 1.4
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 3.6 1.0 0.0 0.4 -0.9 -1.7 -1.9
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.6 0.5 0.0 -0.5 -0.8 -0.5 -0.8
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.2 1.8 0.0 -1.2 -0.6 -0.3 -1.7
Medication: Aspirin 0.3 0.4 1.0 0.5 0.0 -0.3 -0.9 -1.0 -0.2
Supplements: Vitamin C 5.1 6.0 13.3 3.6 0.0 -2.6 -2.4 -1.7 -2.7
Knee pain experienced in last month 0.4 0.6 1.8 0.4 0.0 -0.8 -1.4 -0.8 -0.4
Hypertension (Self-reported) 0.7 2.1 5.3 2.1 0.0 -2.3 -1.5 0.2 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.0 -1.0 0.0 0.9 0.8 0.2 0.4
Illnesses of father: Heart disease 0.3 0.4 0.9 0.9 0.0 -0.9 -0.7 -0.2 -0.2
Illnesses of siblings: Diabetes 0.5 0.6 2.0 0.4 0.0 -1.4 -1.1 -0.2 0.1
Smoking status: Previous 1.3 2.0 5.4 1.9 0.0 -2.3 -1.3 0.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.5 1.2 0.0 -0.6 0.4 0.8 -0.4
Whole body fat-free mass 0.0 0.2 0.6 0.5 0.0 0.4 0.5 0.8 0.2
Leg fat-free mass (right) 0.1 0.5 1.5 1.2 0.0 -0.4 0.2 1.0 0.1
Arm fat percentage (left) 0.5 1.8 7.9 0.4 0.0 -1.1 0.8 2.8 1.1
Average weekly red wine intake 0.2 0.4 0.7 -0.8 0.0 0.8 0.5 -0.3 0.7
Handedness (chirality/laterality): Left-handed 0.2 0.2 1.2 0.2 0.0 -0.0 -0.4 -1.1 -0.0
Mood swings 2.1 3.9 9.7 -1.9 0.0 0.8 1.9 2.4 3.1
Loneliness, isolation 0.7 0.9 2.5 -0.5 0.0 -1.3 -1.0 -0.2 1.6
Long-standing illness, disability or infirmity 0.3 0.5 1.1 -0.8 0.0 -1.0 -0.4 0.5 1.0
Ever had bowel cancer screening 0.6 0.7 3.2 0.0 0.0 -1.8 -0.6 0.7 0.6
Diabetes diagnosed by doctor 1.4 2.3 3.6 1.7 0.0 -1.2 -1.8 -1.7 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.1 4.8 1.4 0.0 -0.4 -1.4 -1.9 -2.2
Friendships satisfaction 1.3 1.6 3.7 0.5 0.0 -0.4 -1.4 -1.8 -1.9
Qualifications: nursing, teaching 0.0 0.1 0.3 0.5 0.0 -0.2 -0.2 0.1 -0.3
Commuting to job workplace: Walk 0.6 0.7 1.9 -0.9 0.0 0.4 1.0 0.5 1.4
Eye problems/disorders: Cataract 4.2 4.9 8.9 1.5 0.0 -2.0 -3.0 -3.0 -2.3
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.0 1.3 0.0 -1.7 -1.2 0.1 -0.5
Medication for cholesterol 1.5 2.3 5.3 -1.2 0.0 2.2 2.3 1.5 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.2 1.2 0.0 -1.5 -1.1 -0.2 0.2
Back pain experienced in last month 0.8 1.1 3.3 -1.3 0.0 1.8 1.2 0.3 0.4
Mineral and other dietary supplements 0.5 0.7 1.7 -1.3 0.0 1.2 0.2 -0.9 -0.2
Breast cancer (self-reported) 1.2 1.4 3.8 0.7 0.0 -0.4 -1.4 -2.0 -1.4
Asthma (self-reported) 0.5 1.0 2.5 0.3 0.0 -0.9 -1.6 -1.6 -0.6
Osteoporosis (self-reported) 1.8 2.2 5.9 2.4 0.0 -2.1 -0.6 0.8 -1.3
Osteoarthritis (self-reported) 1.4 1.8 6.4 -2.5 0.0 0.4 0.4 0.2 2.1
Medication: Aspirin 0.1 0.2 0.6 -0.2 0.0 0.6 -0.3 -0.8 0.0
Medication: Gliclazide 0.2 0.2 0.7 0.1 0.0 0.4 0.0 -0.7 -0.8
Illnesses of father: None of the above (group 1) 0.5 0.6 1.3 -1.1 0.0 0.9 0.7 0.5 0.7
Smoking status: Current 0.4 0.6 1.4 -1.2 0.0 1.1 0.8 0.0 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.5 0.7 0.0 -0.6 0.2 0.7 -0.1
Whole body water mass 0.0 0.2 0.4 0.5 0.0 0.4 0.5 0.7 0.2
Leg predicted mass (right) 0.1 0.5 1.7 1.3 0.0 -0.5 0.1 1.0 0.0
Arm fat mass (left) 0.3 1.4 6.3 0.3 0.0 -0.8 0.8 2.5 0.9
Number of self-reported non-cancer illnesses 0.3 0.5 1.2 -0.6 0.0 0.4 0.6 1.0 1.1
Average weekly champagne plus white wine intake 0.2 0.3 1.4 -0.2 0.0 0.0 -0.7 -1.2 -0.1
Miserableness 0.7 1.3 2.7 -0.4 0.0 -1.5 0.2 1.6 1.6
Guilty feelings 0.7 1.1 3.2 -0.5 0.0 -1.8 -0.4 1.1 1.3
Wears glasses or contact lenses 1.0 1.2 3.6 1.0 0.0 -1.9 -0.7 0.8 1.1
Ever taken oral contraceptive pill 5.6 6.2 13.1 2.8 0.0 -1.6 -2.5 -2.7 -3.6
Hearing aid user 0.2 0.2 0.8 -0.9 0.0 0.4 0.3 -0.2 -0.0
Mother’s age at death 0.6 0.8 3.1 -0.6 0.0 0.6 0.7 0.5 1.8
Financial situation satisfaction 1.5 1.9 5.4 0.4 0.0 -0.6 -1.8 -2.3 -1.4
Tinnitus: Yes, now most or all of the time 2.2 2.5 6.8 -2.6 0.0 2.1 1.1 -0.2 1.7
Commuting to job workplace: Public transport 0.2 0.2 0.7 -0.8 0.0 0.5 0.2 -0.3 0.5
Eye problems/disorders: Glaucoma 0.9 1.0 2.8 -1.2 0.0 -0.3 -1.2 -1.7 0.6
Medication: Blood pressure 0.5 1.0 2.9 0.4 0.0 -1.7 -1.6 -0.7 0.2
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.1 -0.4 0.0 -0.0 0.5 1.1 1.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.6 0.4 0.0 -0.8 0.4 1.3 0.6
High cholesterol (Self-reported) 0.7 1.2 3.0 -1.0 0.0 1.2 1.2 0.8 1.7
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.5 0.0 0.3 -0.1 -0.4 0.3
Medication: Paracetamol 1.3 2.0 3.4 1.1 0.0 -1.1 -1.9 -1.7 -1.8
Medication: Lisinopril 0.1 0.2 0.5 -0.0 0.0 0.4 0.6 0.7 -0.1
Medication: Atorvastatin 0.0 0.0 0.1 -0.3 0.0 -0.1 -0.2 -0.2 -0.1
Illnesses of father: High blood pressure 0.2 0.3 0.7 -0.8 0.0 0.3 0.6 0.5 0.5
Alcohol drinker status: Never 4.2 5.0 12.1 3.5 0.0 -2.4 -2.2 -1.0 -2.6
Ever smoked 2.1 3.8 7.6 2.6 0.0 -2.8 -1.8 -0.4 -2.2
Basal metabolic rate 0.1 0.3 1.0 0.6 0.0 0.2 0.5 1.0 0.1
Leg fat percentage (left) 0.5 1.7 6.0 -0.9 0.0 -0.2 1.0 2.4 1.6
Arm fat-free mass (left) 0.0 0.1 0.3 0.0 0.0 0.3 0.4 0.5 0.2
Number of operations (self-reported) 0.3 0.4 1.6 0.2 0.0 -1.3 -0.8 0.3 -0.2
Average weekly beer plus cider intake 0.1 0.2 0.6 0.2 0.0 -0.4 -0.8 -0.5 -0.1
Irritability 0.4 0.7 2.0 1.1 0.0 -1.4 -0.5 0.8 -0.2
Risk taking 0.9 1.3 2.2 1.1 0.0 -1.0 -1.5 -1.3 -1.3
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.8 -1.2 0.0 0.1 1.0 1.3 1.1
Fractured/broken bones in last 5 years 0.9 1.1 3.2 -0.3 0.0 -0.8 -1.8 -1.7 -0.1
Age started oral contraceptive pill 0.9 1.1 2.8 -1.0 0.0 0.2 1.3 1.7 1.1
Diastolic blood pressure, automated reading 0.2 0.6 2.2 0.3 0.0 0.3 1.0 1.5 0.0
Ever depressed for a whole week 0.8 1.0 2.0 -1.1 0.0 -0.4 0.8 1.3 1.4
Unable to work because of sickness or disability 0.7 0.9 1.6 1.2 0.0 -1.2 -1.0 -0.3 -1.3
Commuting to job workplace: Cycle 0.5 0.6 1.5 0.1 0.0 -1.1 -1.2 -0.7 0.7
Myopia 2.3 3.3 7.8 2.8 0.0 -2.3 -1.9 -0.3 -1.8
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.7 -1.6 0.0 1.5 1.1 -0.3 0.3
Cholesterol lowering medication 0.3 0.5 1.7 -1.3 0.0 0.6 0.3 -0.2 0.8
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.2 -0.1 0.0 -0.1 0.2 0.4 -0.2
Pain experienced in last month 0.9 1.4 3.3 -0.5 0.0 1.4 1.8 1.4 1.1
Supplements: Calcium 5.1 5.6 12.7 3.6 0.0 -3.0 -2.6 -1.0 -2.1
Basal cell carcinoma (self-reported) 1.5 1.8 3.6 1.0 0.0 -1.4 -1.3 -1.5 -1.9
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.4 -0.1 0.0 0.5 -0.3 -0.7 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.1 0.0 -0.4 -0.0 0.4 -0.4
Heart disease (siblings) 0.1 0.1 0.5 -0.0 0.0 0.7 0.1 -0.4 -0.1
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.1 0.0 0.1 -0.5 -0.4 0.1
Pack years of smoking 0.2 0.3 1.1 -0.8 0.0 1.1 0.3 -0.3 0.3
Impedance of whole body 0.1 0.6 1.9 -0.1 0.0 -0.7 0.8 1.4 0.6
Leg fat mass (left) 0.3 1.1 5.0 -0.1 0.0 -0.3 0.8 2.2 1.1
Arm predicted mass (left) 0.0 0.2 0.4 -0.0 0.0 0.6 0.6 0.5 0.2