TWAS hub - ZBTB45

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1200	0.0400	5.2e-05	0.039	NA	0.071	NA	0.076	3.4e-03	NA	9.4e-05	NA	5.2e-05
2	GTEx	Brain Caudate basal ganglia	0.2640	0.0980	5.3e-03	-0.009	NA	0.003	NA	-0.010	7.3e-01	NA	2.6e-01	NA	9.0e-01
3	TCGA	Breast Invasive Carcinoma	0.0201	0.0115	3.1e-03	0.009	0.011	0.011	NA	0.008	5.7e-03	0.00210	1.9e-03	NA	8.8e-03
4	TCGA	Lung Squamous Cell Carcinoma	0.0633	0.0338	2.9e-05	0.057	0.034	0.036	NA	0.052	4.2e-07	0.00009	6.0e-05	NA	1.3e-06
5	TCGA	Soft Tissue Sarcoma	0.1410	0.1010	6.9e-03	0.005	0.001	-0.005	NA	-0.001	1.5e-01	0.26000	1.0e+00	NA	3.8e-01
6	TCGA	Uterine Corpus Endometrial Carcinoma	0.1290	0.0710	8.8e-03	0.018	0.070	0.042	NA	0.026	1.0e-01	0.00540	2.6e-02	NA	6.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6
Ever taken oral contraceptive pill	5.6	6.2	13.1	2.8	-1.6	-2.5	-2.7	-3.6
Supplements: Zinc	5.5	5.9	12.4	3.5	-2.5	-2.6	-1.8	-2.7
Other serious medical condition/disability diagnosed by doctor	5.3	6.9	12.7	-3.6	2.3	2.8	2.0	3.4
Severe depression (siblings)	5.3	5.9	8.9	2.5	-2.3	-3.0	-2.8	-2.7
Hearing difficulty/problems: Yes	5.1	7.8	14.0	-3.7	2.5	3.2	2.6	3.2
Supplements: Vitamin C	5.1	6.0	13.3	3.6	-2.6	-2.4	-1.7	-2.7
Supplements: Calcium	5.1	5.6	12.7	3.6	-3.0	-2.6	-1.0	-2.1
Eye problems/disorders: Cataract	4.2	4.9	8.9	1.5	-2.0	-3.0	-3.0	-2.3
Alcohol drinker status: Never	4.2	5.0	12.1	3.5	-2.4	-2.2	-1.0	-2.6
Bipolar Disorder (2018)	4.0	6.3	16.7	4.1	-2.2	-2.2	-1.2	-3.1
Mouth/teeth dental problems: Loose teeth	3.8	4.5	9.7	3.1	-1.6	-2.0	-1.7	-2.8
Vitamin and mineral supplements	3.7	5.0	11.0	-3.2	3.3	2.6	0.8	1.3
Major Depression (MDD)	3.6	4.3	7.2	2.7	-2.7	-2.3	-1.3	-2.2
Blood Platelet Count	3.5	40.7	74.0	-5.9	5.1	8.1	8.6	6.6
Qualifications: CSEs or equivalent	3.5	4.6	9.3	1.3	-1.4	-2.7	-3.0	-2.7
Diabetes (father)	3.2	4.0	7.7	2.2	-1.7	-2.2	-1.9	-2.8
High blood pressure (mother)	3.2	4.5	8.1	2.4	-2.8	-2.7	-1.4	-2.0
Worry too long after embarrassment	3.1	5.2	15.1	-0.6	-0.8	1.9	3.9	3.4
Multivitamins +/- minerals	3.0	3.9	8.9	2.3	-3.0	-2.5	-1.2	-1.2
Birth weight	2.9	6.3	13.4	-2.8	1.2	2.5	2.9	3.7
Medication for hormone replacement therapy	2.8	3.1	6.7	2.6	-1.5	-1.8	-1.5	-2.1
Intelligence (Savage-Jansen 2018)	2.6	7.9	20.8	4.6	-4.3	-1.9	1.6	-1.5
Crohns Disease (2017)	2.6	5.8	10.2	1.9	-1.6	-2.9	-3.2	-3.2
Headache pain in last month	2.5	4.4	8.9	2.7	-3.0	-2.6	-0.9	-1.6
Depressed Affect (Nagel 2018)	2.3	4.9	14.1	-2.3	0.1	1.6	2.7	3.8
Stomach or abdominal pain in last month	2.3	2.9	8.1	2.9	-1.9	-1.2	0.1	-2.0
Pain all over the body in last month	2.3	2.5	4.5	1.9	-1.8	-1.6	-1.1	-2.1
Neuroticism score	2.3	4.7	12.0	-1.6	-0.4	1.7	3.3	3.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.6	10.2	1.9	-3.2	-2.5	-0.8	-0.9
Suffer from ‘nerves’	2.3	3.5	9.7	-0.8	-0.9	1.1	3.0	3.1
Myopia	2.3	3.3	7.8	2.8	-2.3	-1.9	-0.3	-1.8
Neuroticism	2.2	5.4	13.1	-1.8	-0.4	1.8	3.6	3.5
Chronotype (morning person)	2.2	5.0	15.9	0.8	-1.1	-2.9	-4.0	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.0	10.8	-2.0	3.3	3.0	1.7	1.8
Hearing difficulty/problems with background noise	2.2	3.4	8.6	-1.4	-0.2	1.6	2.9	2.8
Tinnitus: Yes, now most or all of the time	2.2	2.5	6.8	-2.6	2.1	1.1	-0.2	1.7
Neuroticism (Nagel 2018)	2.1	4.9	13.3	-1.0	-1.1	1.3	3.6	3.5
Irritable Bowel Disease (IBD)	2.1	4.9	10.5	1.3	-1.4	-2.9	-3.2	-2.6
Birth weight of first child	2.1	3.8	7.5	-1.2	1.1	2.2	2.7	2.7
Medication: Allopurinol	2.1	2.7	7.1	2.1	-2.7	-2.0	-0.5	-0.8
Mood swings	2.1	3.9	9.7	-1.9	0.8	1.9	2.4	3.1
Ever smoked	2.1	3.8	7.6	2.6	-2.8	-1.8	-0.4	-2.2
Angina	2.0	2.6	6.3	1.1	-0.5	-1.9	-2.5	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	4.8	1.4	-0.4	-1.4	-1.9	-2.2
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	7.9	2.8	-2.4	-1.4	0.2	-1.7
Mean time to correctly identify matches	1.9	3.6	10.4	-3.2	1.8	1.0	0.2	2.6
Bipolar Disorder or Schizophrenia	1.8	4.4	8.0	2.8	-1.7	-2.5	-1.9	-2.4
Heel T-Score	1.8	14.5	30.6	-5.3	5.5	4.2	1.2	3.0
Hair/balding pattern: Pattern 2	1.8	2.2	3.7	1.9	-1.9	-1.4	-1.0	-1.8
Illnesses of mother	1.8	2.2	4.6	-2.1	1.9	1.7	0.6	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	7.6	1.6	-2.8	-1.9	-0.4	-0.2
Osteoporosis (self-reported)	1.8	2.2	5.9	2.4	-2.1	-0.6	0.8	-1.3
Nervous feelings	1.7	3.2	8.2	-1.2	-0.5	1.2	2.8	2.9
Verbal and Numeric Reasoning (VNR)	1.6	3.9	10.9	3.3	-2.7	-0.9	1.5	-1.4
Age when periods started (menarche)	1.6	3.8	16.3	1.0	-1.1	1.6	4.0	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.2	0.4	-2.3	-2.2	-1.1	-0.3
Medication: Amlodipine	1.6	2.2	8.0	-0.9	0.1	1.1	1.9	2.8
Wheeze or whistling in the chest in last year	1.6	2.8	5.8	1.0	-2.0	-2.4	-2.1	-1.3
Angina (self-reported)	1.6	2.1	5.1	1.0	-0.5	-1.8	-2.3	-1.8
Crohns Disease (2012)	1.5	2.5	5.3	1.1	-0.5	-1.8	-2.3	-2.2
Serious illness, injury or assault to yourself	1.5	1.8	6.2	-2.5	0.7	0.2	-0.3	1.9
Medication: Atenolol	1.5	1.9	3.8	2.0	-1.1	-1.5	-1.0	-1.8
Pulse wave reflection index	1.5	1.8	4.7	2.2	-1.2	-1.3	-1.0	-1.5
Family relationship satisfaction	1.5	1.8	6.1	0.2	-0.2	-1.7	-2.5	-1.4
Medication for cholesterol	1.5	2.3	5.3	-1.2	2.2	2.3	1.5	0.4
Financial situation satisfaction	1.5	1.9	5.4	0.4	-0.6	-1.8	-2.3	-1.4
Basal cell carcinoma (self-reported)	1.5	1.8	3.6	1.0	-1.4	-1.3	-1.5	-1.9
Breast Cancer	1.4	3.3	6.1	2.5	-2.4	-2.1	-0.9	-1.6
Coronary Artery Disease (CAD)	1.4	1.6	3.8	0.7	-0.3	-1.5	-1.8	-1.9
Past tobacco smoking	1.4	2.5	6.4	-2.2	2.5	1.5	0.0	1.4
Fluid intelligence score	1.4	3.0	9.0	3.0	-2.4	-0.9	1.1	-1.2
Length of working week for main job	1.4	1.6	4.6	0.5	-2.1	-2.0	-0.9	-0.1
Gout (self-reported)	1.4	2.0	5.5	1.9	-2.3	-1.5	-0.1	-0.7
Diabetes diagnosed by doctor	1.4	2.3	3.6	1.7	-1.2	-1.8	-1.7	-1.9
Osteoarthritis (self-reported)	1.4	1.8	6.4	-2.5	0.4	0.4	0.2	2.1
Worry (Nagel 2018)	1.3	2.8	9.5	-0.3	-1.1	0.8	3.1	2.3
Hand grip strength (left)	1.3	3.5	10.7	-2.0	3.3	2.2	0.4	0.9
Sensitivity / hurt feelings	1.3	2.2	6.2	1.5	-1.7	0.4	2.5	1.4
Relative age of first facial hair	1.3	2.8	9.9	1.9	-1.3	1.1	3.1	0.5
Relative age voice broke	1.3	2.0	8.0	1.0	-0.7	1.3	2.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	4.4	-1.9	2.1	2.1	1.3	1.9
Medication: Ramipril	1.3	1.7	3.7	1.5	-1.9	-1.7	-0.5	-1.1
Medication: Lansoprazole	1.3	1.5	3.2	-1.8	1.5	1.6	0.9	0.6
Medication: Paracetamol	1.3	2.1	4.2	1.0	-0.7	-1.9	-2.0	-1.8
Leg pain on walking	1.3	1.7	2.9	-1.5	1.1	1.7	1.4	1.4
Smoking status: Previous	1.3	2.0	5.4	1.9	-2.3	-1.3	0.1	-1.0
Friendships satisfaction	1.3	1.6	3.7	0.5	-0.4	-1.4	-1.8	-1.9
Medication: Paracetamol	1.3	2.0	3.4	1.1	-1.1	-1.9	-1.7	-1.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.5	1.2	-1.3	-1.6	-1.3	-0.6
Hand grip strength (right)	1.2	3.4	7.1	-1.9	2.7	2.6	1.2	1.2
Breastfed as a baby	1.2	1.5	4.0	-0.9	0.7	1.3	1.4	2.0
Eye problems/disorders: None of the above	1.2	1.3	4.8	-0.1	0.3	1.4	2.2	1.1
Alcohol intake frequency.	1.2	2.9	8.2	2.9	-1.5	-1.4	-0.5	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.6	1.0	0.4	-0.9	-1.7	-1.9
Breast cancer (self-reported)	1.2	1.4	3.8	0.7	-0.4	-1.4	-2.0	-1.4
Supplements: Glucosamine	1.1	1.5	4.5	1.8	-2.1	-1.0	0.2	-0.6
Medication: Levothyroxine sodium	1.1	1.8	4.9	-2.2	1.3	1.4	0.9	1.2
Worrier / anxious feelings	1.1	2.0	5.4	-0.5	-1.1	0.6	2.2	2.3
Depression (self-reported)	1.1	1.3	3.4	1.7	-1.9	-0.6	1.0	-0.3
Hair/balding pattern: Pattern 4	1.1	2.7	6.4	-2.5	2.5	1.4	0.3	1.3
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.0	-0.1	0.7	-1.1	-2.0	-1.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.2	1.8	-1.2	-0.6	-0.3	-1.7
Diabetes (mother)	1.0	1.2	3.7	1.9	-1.1	-0.9	0.1	-1.3
Number of incorrect matches in round	1.0	1.7	4.0	-2.0	1.5	0.6	-0.3	1.9
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.2	0.8	-2.1	-1.4	-0.4	-0.4
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	4.9	-2.2	1.9	1.2	0.3	1.1
Chest pain or discomfort	1.0	1.4	2.7	1.1	-1.3	-1.6	-1.1	-1.3
Wears glasses or contact lenses	1.0	1.2	3.6	1.0	-1.9	-0.7	0.8	1.1
Ulcerative Colitis (UC)	0.9	1.8	4.1	0.6	-1.2	-2.0	-1.9	-1.0
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.7	1.5	-1.9	-1.1	0.1	-0.3
Diabetes (self-reported)	0.9	1.3	2.2	1.0	-1.1	-1.5	-1.4	-1.3
Medication: Cholesterol lowering	0.9	1.4	3.9	-1.0	1.1	1.1	0.9	2.0
Eye problems/disorders: Glaucoma	0.9	1.0	2.8	-1.2	-0.3	-1.2	-1.7	0.6
Risk taking	0.9	1.3	2.2	1.1	-1.0	-1.5	-1.3	-1.3
Fractured/broken bones in last 5 years	0.9	1.1	3.2	-0.3	-0.8	-1.8	-1.7	-0.1
Age started oral contraceptive pill	0.9	1.1	2.8	-1.0	0.2	1.3	1.7	1.1
Pain experienced in last month	0.9	1.4	3.3	-0.5	1.4	1.8	1.4	1.1
Glaucoma (self-reported)	0.8	1.0	2.8	-1.7	0.1	-0.3	-0.6	1.6
Pulse wave peak to peak time	0.8	0.9	3.5	-1.1	0.2	0.4	0.8	1.9
Back pain experienced in last month	0.8	1.1	3.3	-1.3	1.8	1.2	0.3	0.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.8	-1.2	0.1	1.0	1.3	1.1
Ever depressed for a whole week	0.8	1.0	2.0	-1.1	-0.4	0.8	1.3	1.4
Blood Eosinophil Count	0.7	5.6	13.0	-2.8	1.7	2.2	2.4	3.6
Hypothyroidism (self reported)	0.7	1.6	4.2	-2.0	2.0	0.9	-0.3	0.9
Trunk fat percentage	0.7	2.9	12.4	0.3	-1.0	1.4	3.5	1.5
Had menopause	0.7	0.9	1.8	-1.3	1.4	1.0	0.4	0.9
Allergy	0.7	1.6	3.0	-0.7	1.1	1.7	1.6	1.5
Time employed in main current job	0.7	0.8	3.3	-0.7	-0.7	-0.4	0.5	1.8
Loud music exposure frequency	0.7	0.8	1.9	0.2	-0.7	0.6	1.3	1.4
High blood pressure (siblings)	0.7	1.0	2.6	-0.4	-1.2	0.0	1.4	1.6
Body fat percentage	0.7	2.6	11.0	0.0	-0.8	1.2	3.3	1.6
Medication: Ibuprofen	0.7	0.8	2.9	-0.1	-1.7	-1.3	-0.1	0.4
Hypertension (Self-reported)	0.7	2.1	5.3	2.1	-2.3	-1.5	0.2	-0.5
Loneliness, isolation	0.7	0.9	2.5	-0.5	-1.3	-1.0	-0.2	1.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.0	1.3	-1.7	-1.2	0.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	1.2	-1.5	-1.1	-0.2	0.2
Miserableness	0.7	1.3	2.7	-0.4	-1.5	0.2	1.6	1.6
Guilty feelings	0.7	1.1	3.2	-0.5	-1.8	-0.4	1.1	1.3
High cholesterol (Self-reported)	0.7	1.2	3.0	-1.0	1.2	1.2	0.8	1.7
Unable to work because of sickness or disability	0.7	0.9	1.6	1.2	-1.2	-1.0	-0.3	-1.3
Bipolar Disorder (2011)	0.6	0.6	3.7	1.9	0.0	0.0	0.0	0.0
Lupus	0.6	1.0	2.6	-0.9	1.4	-0.4	-1.6	0.5
Neuroticism (2016)	0.6	0.9	2.6	-0.7	-0.1	0.9	1.6	1.2
Schizophrenia (2014)	0.6	1.2	2.6	1.1	-0.8	-1.6	-1.5	-0.8
Blood White Count	0.6	4.4	12.0	-1.8	0.6	2.4	3.5	2.2
Medication: Co-codamol	0.6	0.7	1.6	1.1	-1.3	-0.8	0.5	-0.7
Average weekly fortified wine intake	0.6	0.7	2.9	0.6	-0.7	0.8	1.7	-0.1
Fed-up feelings	0.6	1.0	3.9	-0.9	0.0	0.4	1.1	2.0
High blood pressure	0.6	1.6	4.0	2.0	-2.0	-1.2	0.5	-0.4
Trunk fat mass	0.6	2.6	11.2	0.3	-0.7	1.4	3.3	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.0	0.2	-1.3	0.4	1.7	0.9
Medication: Simvastatin	0.6	0.9	3.1	-1.0	0.5	0.9	0.8	1.8
Father’s age at death	0.6	0.8	1.4	-1.0	1.2	1.1	0.8	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.7	-0.7	-0.9	0.1	1.5	1.6
Qualifications: A levels/AS levels or equivalent	0.6	1.2	3.1	1.8	-1.1	0.0	0.8	-1.5
Pulse wave Arterial Stiffness index	0.6	0.7	2.9	1.0	-0.1	-0.3	-0.6	-1.7
Tense / ‘highly strung’	0.6	1.0	2.4	0.5	-1.4	-0.0	1.6	1.1
Number of children fathered	0.6	0.6	1.4	-1.0	0.1	0.6	1.1	1.2
Ever had bowel cancer screening	0.6	0.7	3.2	0.0	-1.8	-0.6	0.7	0.6
Commuting to job workplace: Walk	0.6	0.7	1.9	-0.9	0.4	1.0	0.5	1.4
Mother’s age at death	0.6	0.8	3.1	-0.6	0.6	0.7	0.5	1.8
Reaction Time	0.5	1.0	3.7	-1.9	0.7	-0.2	-0.8	1.0
Mean Putamen Volume	0.5	0.6	2.2	-1.5	0.8	0.4	-0.3	0.8
Rheumatoid Arthritis	0.5	0.7	1.0	-0.9	0.9	0.9	0.8	1.0
Ulcerative Colitis	0.5	0.7	2.2	-0.8	-0.2	-1.0	-1.5	0.6
Allergy or Eczema	0.5	1.2	2.3	0.7	-1.4	-1.5	-1.1	-1.1
Number of treatments/medications taken	0.5	0.9	2.7	1.1	-1.6	-0.8	0.9	0.3
Pack years adult smoking proportion	0.5	0.7	2.1	-1.2	1.4	0.5	-0.4	0.5
Current tobacco smoking	0.5	0.8	2.2	-1.5	1.3	1.0	0.1	0.3
Hayfever, allergic rhinitis or eczema	0.5	1.2	1.7	0.9	-1.2	-1.3	-1.1	-1.3
Pulse rate	0.5	0.8	2.1	-1.0	0.6	1.4	1.2	0.2
Shortness of breath walking on level ground	0.5	0.6	1.8	-1.0	0.3	0.5	0.8	1.4
Medication for pain relief, constipation, heartburn	0.5	0.8	2.0	0.7	0.7	1.4	1.2	-0.4
Whole body fat mass	0.5	2.2	9.2	0.1	-0.6	1.3	3.0	1.4
Illnesses of siblings: Diabetes	0.5	0.6	2.0	0.4	-1.4	-1.1	-0.2	0.1
Arm fat percentage (left)	0.5	1.8	7.9	0.4	-1.1	0.8	2.8	1.1
Mineral and other dietary supplements	0.5	0.7	1.7	-1.3	1.2	0.2	-0.9	-0.2
Asthma (self-reported)	0.5	1.0	2.5	0.3	-0.9	-1.6	-1.6	-0.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	-1.1	0.9	0.7	0.5	0.7
Medication: Blood pressure	0.5	1.0	2.9	0.4	-1.7	-1.6	-0.7	0.2
Leg fat percentage (left)	0.5	1.7	6.0	-0.9	-0.2	1.0	2.4	1.6
Commuting to job workplace: Cycle	0.5	0.6	1.5	0.1	-1.1	-1.2	-0.7	0.7
Schizophrenia (2018)	0.4	0.8	2.2	0.4	-0.4	-1.4	-1.5	-0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	-1.2	0.5	0.6	0.3	1.0
Ovarian Cancer	0.4	0.5	1.5	0.7	-0.9	0.2	1.2	0.3
Body Mass Index (BMI) (2010)	0.4	0.6	1.6	0.4	1.3	0.2	-0.5	-1.2
Fasting Glucose	0.4	0.4	1.0	0.1	0.8	-0.3	-0.9	-1.0
Primary Biliary Cirrhosis	0.4	0.6	2.1	0.0	0.3	1.1	1.5	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.9	1.4	-0.9	-0.5	0.1	-0.3
Alcohol usually taken with meals	0.4	0.7	1.4	-1.0	0.0	-0.8	-1.2	0.9
Had other major operations	0.4	0.5	2.0	0.6	-0.1	0.8	1.4	-0.4
Illnesses of siblings	0.4	0.5	1.8	-0.2	1.4	0.9	-0.3	-0.6
Arm fat percentage (right)	0.4	1.5	6.0	0.6	-1.3	0.4	2.4	0.9
Happiness	0.4	0.5	1.9	-0.1	0.2	-0.7	-1.4	-0.9
Prospective memory result	0.4	0.5	1.4	0.0	-0.2	-1.1	-1.2	0.4
Peak expiratory flow (PEF)	0.4	1.0	2.3	1.5	-0.8	0.5	1.4	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.1	0.8	-1.0	-0.8	-0.6	-0.6
Leg fat percentage (right)	0.4	1.6	5.5	-0.8	-0.2	0.9	2.4	1.6
Knee pain experienced in last month	0.4	0.6	1.8	0.4	-0.8	-1.4	-0.8	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-1.0	0.9	0.8	0.2	0.4
Smoking status: Current	0.4	0.6	1.4	-1.2	1.1	0.8	0.0	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	0.4	-0.8	0.4	1.3	0.6
Irritability	0.4	0.7	2.0	1.1	-1.4	-0.5	0.8	-0.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.7	-1.6	1.5	1.1	-0.3	0.3
Alzheimer’s Disease (in father)	0.3	0.4	0.8	0.8	-0.9	0.0	0.7	0.4
HDL Cholesterol	0.3	0.4	1.1	-1.1	-0.7	-0.1	0.1	1.0
LDL Cholesterol	0.3	0.5	1.3	-0.2	0.9	1.1	0.8	0.5
Triglycerides	0.3	0.5	1.7	-0.0	1.3	0.9	0.3	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.1	-0.6	0.5	0.1	0.3	1.1
Height	0.3	5.1	11.6	-1.0	1.9	3.4	3.3	1.9
Medication: Metformin	0.3	0.4	1.3	0.8	-1.2	-0.6	0.1	0.0
Taking other prescription medications	0.3	0.5	1.2	0.4	-0.9	-1.1	-0.6	-0.5
Waist circumference	0.3	0.9	3.1	0.6	-1.0	0.2	1.8	1.0
Qualifications: None of the above	0.3	0.7	2.3	-1.5	0.4	0.2	0.1	1.3
Financial difficulties in last 2 years	0.3	0.4	1.6	-1.3	0.6	-0.2	-0.3	0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	0.9	0.9	-0.7	-1.0	-0.6	-0.4
Hip circumference	0.3	1.4	5.2	1.2	-1.2	0.5	2.3	0.2
Asthma	0.3	0.6	1.5	0.1	-0.7	-1.2	-1.2	-0.3
Exposure to tobacco smoke at home	0.3	0.3	1.0	1.0	-0.7	-0.1	0.4	-0.5
Comparative body size at age 10	0.3	0.9	3.0	0.8	-1.2	0.3	1.7	0.3
Number of full brothers	0.3	0.3	1.3	-1.1	0.7	0.3	-0.0	0.2
Health satisfaction	0.3	0.4	1.6	-0.6	0.1	-0.7	-1.3	0.0
Emphysema/chronic bronchitis	0.3	0.3	1.6	-1.3	-0.2	0.0	-0.1	-0.3
Medication: Seretide 50 evohaler	0.3	0.4	1.1	0.3	0.2	-0.6	-0.8	-1.1
Leg fat mass (right)	0.3	1.1	5.1	0.0	-0.4	0.7	2.3	1.0
Number of full sisters	0.3	0.4	1.1	-0.8	0.6	-0.3	-1.0	0.1
Age at last live birth	0.3	0.4	0.8	0.4	-0.9	-0.7	-0.7	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.5	-0.5	-0.8	-0.5	-0.8
Medication: Aspirin	0.3	0.4	1.0	0.5	-0.3	-0.9	-1.0	-0.2
Illnesses of father: Heart disease	0.3	0.4	0.9	0.9	-0.9	-0.7	-0.2	-0.2
Long-standing illness, disability or infirmity	0.3	0.5	1.1	-0.8	-1.0	-0.4	0.5	1.0
Arm fat mass (left)	0.3	1.4	6.3	0.3	-0.8	0.8	2.5	0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	-0.6	0.4	0.6	1.0	1.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.4	-0.0	0.5	1.1	1.1
Number of operations (self-reported)	0.3	0.4	1.6	0.2	-1.3	-0.8	0.3	-0.2
Cholesterol lowering medication	0.3	0.5	1.7	-1.3	0.6	0.3	-0.2	0.8
Leg fat mass (left)	0.3	1.1	5.0	-0.1	-0.3	0.8	2.2	1.1
Depression (Nagel 2018)	0.2	0.3	1.4	0.3	0.0	0.5	1.2	0.6
Age at First Birth	0.2	0.3	0.9	-0.8	0.1	0.6	0.4	1.0
Cardiovascular Disease	0.2	0.8	2.4	1.5	-1.2	-0.4	0.8	0.1
Respiratory disease	0.2	0.5	1.3	-1.1	-0.7	-0.4	0.1	1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	0.1	-0.4	-0.9	-0.9	-0.5
Hair Pigment	0.2	6.7	13.2	-3.0	3.6	3.1	1.5	2.5
Average weekly spirits intake	0.2	0.2	0.6	-0.4	0.8	0.1	-0.5	-0.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	-0.8	0.2	-0.1	-0.1	0.7
Systolic blood pressure, automated reading	0.2	0.5	1.8	0.3	0.2	0.9	1.4	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	-0.3	-0.2	0.0	0.5	1.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	-0.1	-0.9	-0.1	0.4	-0.1
Sitting height	0.2	1.5	4.0	-0.6	1.4	2.0	1.4	0.6
Forced vital capacity (FVC)	0.2	0.9	1.8	1.4	0.0	1.1	1.1	-1.0
Mouth/teeth dental problems	0.2	0.4	0.9	-0.8	0.4	1.0	0.7	0.4
Weight	0.2	1.2	5.5	0.5	-0.3	1.0	2.3	0.7
Impedance of arm (right)	0.2	1.0	3.7	1.1	-1.9	-0.2	1.1	0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.1	-0.4	-0.9	-0.8	-0.4
Falls in the last year	0.2	0.3	0.6	-0.6	0.7	0.6	0.3	0.7
Hair/balding pattern: Pattern 3	0.2	0.4	1.3	-0.3	-0.6	-0.1	0.7	1.1
Number of live births	0.2	0.3	0.9	-0.5	0.1	0.7	0.9	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.4	0.8	0.1	1.1	1.2	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.3	0.8	0.5	0.4	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	0.4	0.6	-0.4	-0.9	-0.8
Lung cancer (father)	0.2	0.3	1.2	-0.3	1.1	0.2	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.8	0.8	-0.4	1.0	1.7	0.2
Impedance of arm (left)	0.2	1.1	3.8	0.4	-1.2	0.9	1.9	0.9
Arm fat mass (right)	0.2	1.0	4.5	0.6	-0.8	0.5	2.1	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.1	-0.1	-0.4	-0.7	-1.0
Forced vital capacity (FVC), Best measure	0.2	0.8	2.5	0.9	-0.3	1.1	1.6	0.2
Qualifications: College or University degree	0.2	0.8	2.2	-0.3	0.2	1.3	1.5	0.6
Neck or shoulder pain in last month	0.2	0.3	0.9	0.3	-0.2	-0.4	-0.7	-1.0
Medication: Blood pressure	0.2	0.4	1.7	1.3	-0.6	-0.6	-0.1	-0.4
Migraine (self-reported)	0.2	0.3	1.1	0.5	-1.1	-0.6	0.2	0.0
Medication: Omeprazole	0.2	0.2	0.6	-0.8	0.5	0.6	0.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	0.8	0.0	-0.6	-0.5	-0.7
Comparative height size at age 10	0.2	0.9	3.1	-0.8	1.7	1.2	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.5	1.2	-0.6	0.4	0.8	-0.4
Average weekly red wine intake	0.2	0.4	0.7	-0.8	0.8	0.5	-0.3	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	1.2	0.2	-0.0	-0.4	-1.1	-0.0
Medication: Gliclazide	0.2	0.2	0.7	0.1	0.4	0.0	-0.7	-0.8
Average weekly champagne plus white wine intake	0.2	0.3	1.4	-0.2	0.0	-0.7	-1.2	-0.1
Hearing aid user	0.2	0.2	0.8	-0.9	0.4	0.3	-0.2	-0.0
Commuting to job workplace: Public transport	0.2	0.2	0.7	-0.8	0.5	0.2	-0.3	0.5
Illnesses of father: High blood pressure	0.2	0.3	0.7	-0.8	0.3	0.6	0.5	0.5
Diastolic blood pressure, automated reading	0.2	0.6	2.2	0.3	0.3	1.0	1.5	0.0
Pack years of smoking	0.2	0.3	1.1	-0.8	1.1	0.3	-0.3	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.1	-0.6	-0.2	0.1	0.5
Prostate Cancer	0.1	0.1	0.3	0.3	-0.5	-0.2	0.4	-0.0
HbA1C	0.1	0.1	0.4	0.7	0.0	-0.4	-0.1	-0.3
Blood Red Count	0.1	1.2	4.2	0.8	0.3	1.1	2.1	-0.8
BMI	0.1	0.6	2.5	0.4	-0.7	0.4	1.6	0.6
Waist Hip Ratio (WHR)	0.1	0.5	1.7	-0.6	-0.2	-1.0	-1.3	0.2
Systolic Blood Pressure	0.1	0.5	1.5	0.5	0.3	1.0	1.2	0.5
Smoking Status	0.1	0.3	0.8	0.5	-0.3	0.2	0.6	-0.9
Lung FEV1/FVC ratio	0.1	0.5	1.9	-0.8	-0.5	-0.1	0.6	1.4
Tanning	0.1	0.7	1.7	-1.3	-0.9	-0.7	-0.2	1.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.5	0.2	-0.3	0.1	0.7	0.2
Leg fat-free mass (left)	0.1	0.7	2.0	1.4	-0.6	0.2	1.3	0.1
Townsend deprivation index at recruitment	0.1	0.1	0.4	-0.5	0.3	-0.3	-0.6	0.0
Maternal smoking around birth	0.1	0.2	0.8	0.9	-0.1	0.0	0.4	-0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.1	0.1	0.3	0.3	-0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.0	-0.4	0.2	0.3	0.4
Body mass index (BMI)	0.1	0.5	2.1	0.5	-0.6	0.1	1.4	0.1
Impedance of leg (left)	0.1	0.4	1.4	-1.2	0.6	0.7	0.2	0.4
Leg predicted mass (left)	0.1	0.6	2.0	1.4	-0.5	0.2	1.2	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.3	-0.4	-0.4	-0.2	0.1
Heart attack	0.1	0.2	0.6	-0.1	0.4	-0.5	-0.7	-0.3
Trunk fat-free mass	0.1	0.3	1.1	-0.1	1.1	0.8	0.4	0.2
Noisy workplace	0.1	0.1	0.2	-0.3	0.4	0.5	0.0	0.2
Standing height	0.1	1.5	4.0	0.3	0.6	1.9	2.0	0.8
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	0.3	-0.6	-0.4	0.2	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.5	-0.2	-0.3	0.3	0.7	-0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.4	0.5	0.2	-0.2	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.6	0.2	0.2	0.1	0.5
Pulse rate, automated reading	0.1	0.3	1.0	-0.2	-0.5	0.6	1.0	0.0
Overall health rating	0.1	0.3	1.0	-0.2	-1.0	-0.7	0.2	0.6
Had major operations	0.1	0.1	0.4	-0.3	0.3	-0.3	-0.7	-0.1
Leg fat-free mass (right)	0.1	0.5	1.5	1.2	-0.4	0.2	1.0	0.1
Medication: Aspirin	0.1	0.2	0.6	-0.2	0.6	-0.3	-0.8	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.7	-0.6	0.2	0.7	-0.1
Leg predicted mass (right)	0.1	0.5	1.7	1.3	-0.5	0.1	1.0	0.0
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.5	0.3	-0.1	-0.4	0.3
Medication: Lisinopril	0.1	0.2	0.5	-0.0	0.4	0.6	0.7	-0.1
Basal metabolic rate	0.1	0.3	1.0	0.6	0.2	0.5	1.0	0.1
Average weekly beer plus cider intake	0.1	0.2	0.6	0.2	-0.4	-0.8	-0.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	-0.1	0.5	-0.3	-0.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.1	-0.4	-0.0	0.4	-0.4
Heart disease (siblings)	0.1	0.1	0.5	-0.0	0.7	0.1	-0.4	-0.1
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.1	0.1	-0.5	-0.4	0.1
Impedance of whole body	0.1	0.6	1.9	-0.1	-0.7	0.8	1.4	0.6
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.1	0.3
Lung FVC	0.0	0.2	0.4	-0.3	0.7	0.3	-0.3	-0.5
Impedance of leg (right)	0.0	0.2	0.6	-0.8	0.3	0.5	0.1	0.2
Trunk predicted mass	0.0	0.3	0.9	-0.0	1.0	0.7	0.3	0.1
Arm fat-free mass (right)	0.0	0.2	0.5	0.1	0.5	0.6	0.7	0.2
Age at first live birth	0.0	0.1	0.4	0.1	-0.6	-0.0	0.1	0.0
Heart disease (mother)	0.0	0.0	0.1	-0.0	0.1	0.2	0.3	-0.3
Arm predicted mass (right)	0.0	0.2	0.5	0.1	0.7	0.6	0.5	0.2
Whole body fat-free mass	0.0	0.2	0.6	0.5	0.4	0.5	0.8	0.2
Qualifications: nursing, teaching	0.0	0.1	0.3	0.5	-0.2	-0.2	0.1	-0.3
Whole body water mass	0.0	0.2	0.4	0.5	0.4	0.5	0.7	0.2
Medication: Atorvastatin	0.0	0.0	0.1	-0.3	-0.1	-0.2	-0.2	-0.1
Arm fat-free mass (left)	0.0	0.1	0.3	0.0	0.3	0.4	0.5	0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.2	-0.1	-0.1	0.2	0.4	-0.2
Arm predicted mass (left)	0.0	0.2	0.4	-0.0	0.6	0.6	0.5	0.2

Hub : Genes

ZBTB45

Models

Trait associations