Hub : Genes

ZFYVE20

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.3350	0.1050	8.4e-03	0.068	NA	0.027	NA	0.059	6.0e-03	NA	6.0e-02	NA	9.6e-03
2	GTEx	Nerve Tibial	0.1684	0.0646	6.0e-03	0.006	NA	0.004	NA	0.005	1.2e-01	NA	1.6e-01	NA	1.3e-01
3	YFS	Blood	0.0452	0.0114	3.5e-09	0.046	0.036	0.044	0.046	0.046	6.0e-15	7.6e-12	3.3e-14	1e-14	9.0e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.2	1.9	1.2	0.2	1.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	-0.1	-0.2	0.9
Depressed Affect (Nagel 2018)	0.5	1.1	2.9	-0.5	-1.7	0.2
Depression (Nagel 2018)	0.4	0.7	1.1	-0.6	0.7	-1.0
Intelligence (Savage-Jansen 2018)	1.0	3.2	6.6	0.5	1.7	2.6
Neuroticism (Nagel 2018)	0.4	0.8	2.3	-1.5	0.4	0.2
Schizophrenia (2018)	0.2	0.5	1.4	-1.2	-0.4	0.1
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	-0.5	0.5	0.3
Worry (Nagel 2018)	2.1	4.3	8.4	-2.9	2.1	-0.2
Alzheimer’s Disease (in mother)	0.8	1.0	2.6	-0.2	0.4	1.6
Alzheimer’s Disease (in father)	1.1	1.2	2.2	1.5	-0.5	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	0.2	0.5	0.9
Crohns Disease (2017)	0.4	0.8	2.2	1.5	-0.4	-0.1
Irritable Bowel Disease (IBD)	0.4	0.9	1.9	1.4	-0.7	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.4	-0.2	-0.7
Major Depression (MDD)	1.2	1.5	3.1	-1.0	-0.6	1.8
Reaction Time	0.1	0.2	0.4	0.6	0.5	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.4	-0.4	0.6	1.8
Breast Cancer	0.1	0.2	0.5	-0.1	0.4	0.7
Ovarian Cancer	0.2	0.2	0.5	0.7	-0.3	0.2
Prostate Cancer	0.9	1.3	1.9	-1.4	0.3	-1.4
Age at First Birth	0.7	1.1	2.2	-1.5	1.0	0.3
Bipolar Disorder (2011)	2.1	2.0	3.0	1.7	-1.3	1.2
Body Mass Index (BMI) (2010)	1.3	1.8	3.1	1.0	-1.1	1.8
Coronary Artery Disease (CAD)	0.5	0.6	1.3	1.1	-0.2	0.7
Crohns Disease (2012)	0.6	0.9	2.8	1.7	0.1	0.1
Mean Putamen Volume	0.5	0.5	0.7	0.5	0.9	-0.8
Fasting Glucose	0.3	0.4	0.8	-0.4	-0.4	0.9
HbA1C	0.7	0.8	1.3	0.9	-1.1	-0.5
HDL Cholesterol	0.1	0.2	0.6	-0.2	0.7	0.1
LDL Cholesterol	0.6	0.9	1.1	-1.1	-0.8	-1.0
Lupus	0.8	1.2	3.3	1.8	-0.4	-0.2
Neuroticism (2016)	0.7	0.9	2.0	-0.5	-0.7	-1.4
Primary Biliary Cirrhosis	0.7	1.0	1.9	-0.2	-1.0	1.4
Rheumatoid Arthritis	0.4	0.6	0.9	-0.8	-0.4	0.9
Schizophrenia (2014)	0.2	0.5	1.0	-0.6	-0.1	1.0
Triglycerides	0.8	1.4	1.9	-1.0	-1.1	-1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	0.1	-0.4	1.4
Ulcerative Colitis	0.4	0.5	1.1	0.7	0.0	-1.0
Blood Eosinophil Count	0.3	2.2	4.4	0.8	-1.2	-2.1
Blood Platelet Count	0.2	2.6	5.3	-1.0	2.3	-1.2
Blood Red Count	0.7	6.8	8.4	2.2	-2.9	-2.7
Blood White Count	1.4	10.6	26.6	1.6	-1.6	-5.2
Heel T-Score	0.1	1.0	1.3	-0.9	1.1	-1.1
BMI	0.1	0.8	1.7	0.4	-1.3	0.7
Height	0.3	6.1	11.2	1.2	-2.4	3.4
Waist Hip Ratio (WHR)	0.7	3.3	5.1	-2.1	2.2	0.8
Systolic Blood Pressure	0.4	1.8	4.4	0.7	2.1	-0.7
Smoking Status	0.8	2.0	4.1	0.9	-2.0	-1.0
Allergy or Eczema	0.7	1.8	3.5	1.9	-1.4	0.1
Cardiovascular Disease	0.2	0.7	1.5	-0.2	0.8	-1.2
Hypothyroidism (self reported)	0.8	1.7	2.2	1.1	-1.4	-1.5
Respiratory disease	0.2	0.5	0.9	0.8	-0.9	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.4	-0.4	-0.4	-0.6
Lung FEV1/FVC ratio	0.1	0.6	1.1	0.5	0.6	1.0
Lung FVC	0.4	2.1	4.2	-1.3	-0.5	-2.0
Neuroticism	0.7	1.7	5.0	-2.2	-0.2	-0.4
Chronotype (morning person)	0.4	1.0	1.8	0.9	-0.6	-1.4
Hair Pigment	0.0	0.6	1.5	-0.5	0.1	-1.2
Tanning	0.2	2.7	5.4	-1.3	-2.3	1.0
Hand grip strength (left)	0.5	1.3	3.4	0.4	1.8	0.6
Number of treatments/medications taken	0.3	0.6	0.9	0.8	-0.5	-1.0
Average weekly spirits intake	0.9	1.1	2.6	0.8	-1.6	-0.4
Sensitivity / hurt feelings	0.4	0.6	1.2	-0.7	0.5	1.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.7	-0.8	0.8	-0.2
Hearing difficulty/problems: Yes	1.5	2.2	5.7	-0.8	2.4	0.6
Relative age of first facial hair	0.1	0.3	0.6	-0.1	-0.4	-0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.3	0.8	-1.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	-0.6	-0.6	0.7
Ever had hysterectomy (womb removed)	0.8	0.9	1.7	1.3	-0.9	-0.6
Systolic blood pressure, automated reading	0.8	2.3	4.0	1.7	2.0	-0.2
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	6.8	2.6	-0.3	-1.6
Angina	0.5	0.6	1.4	-0.4	-0.4	-1.2
Medication for hormone replacement therapy	3.8	4.3	7.8	0.8	-2.1	-2.8
Vitamin and mineral supplements	0.2	0.3	0.7	-0.8	0.3	0.1
Supplements: Zinc	0.2	0.2	0.6	0.8	0.1	-0.4
Medication: Co-codamol	0.2	0.2	0.7	0.8	-0.0	0.1
Medication: Metformin	0.2	0.3	0.7	0.4	-0.4	-0.8
Diabetes (father)	0.6	0.7	1.6	1.3	-0.7	-0.1
Diabetes (mother)	0.4	0.5	0.7	-0.8	-0.4	-0.8
Severe depression (siblings)	0.7	0.8	1.4	0.7	1.2	0.7
Pack years adult smoking proportion	0.7	1.1	2.1	-0.1	-1.4	-1.0
Impedance of leg (right)	0.5	2.6	6.8	-1.0	-0.1	-2.6
Leg fat-free mass (left)	0.9	4.6	9.6	1.2	-1.7	3.1
Trunk fat percentage	0.1	0.5	1.5	-1.2	0.0	0.2
Hand grip strength (right)	0.3	0.8	2.3	0.3	1.5	0.3
Townsend deprivation index at recruitment	2.4	3.4	7.4	-2.7	-0.9	1.5
Current tobacco smoking	3.1	5.0	8.1	1.2	-2.9	-2.3
Average weekly fortified wine intake	1.0	1.1	2.9	0.6	0.3	1.7
Maternal smoking around birth	0.9	1.3	1.8	1.4	-0.4	-1.3
Fed-up feelings	0.3	0.5	0.8	0.3	-0.7	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.6	-1.3	0.5	-1.1
Relative age voice broke	0.5	0.8	1.4	1.1	-1.2	-0.1
Taking other prescription medications	0.2	0.3	1.0	0.1	-1.0	0.2
Age when periods started (menarche)	0.4	0.9	1.8	-1.4	0.9	-0.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.2	0.7	-1.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.1	0.4	1.0	-0.7
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	3.9	-1.2	2.0	-1.4
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.5	0.1	-0.5
Serious illness, injury or assault to yourself	1.0	1.2	2.4	1.2	-0.2	1.5
High blood pressure	0.2	0.5	0.8	0.4	0.9	-0.8
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.4	1.6	-0.3	0.3
Multivitamins +/- minerals	0.5	0.7	2.0	1.4	0.1	0.1
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.3	-0.2	-0.4
Supplements: Glucosamine	1.9	2.5	4.7	1.6	0.4	2.2
Diverticular disease/diverticulitis (self-reported)	3.5	4.2	9.5	3.1	1.1	-1.4
Medication: Atenolol	1.5	1.8	4.5	-2.1	-0.6	0.8
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.3	0.2	-0.8
Sitting height	0.8	5.9	12.7	0.6	-2.1	3.6
Chronic bronchitis/emphysema (father)	1.0	1.2	3.2	-1.8	-0.4	-0.5
High blood pressure (mother)	0.5	0.8	1.4	0.5	-0.8	1.2
Body mass index (BMI)	0.2	0.9	2.1	0.7	-0.4	1.4
Impedance of leg (left)	0.5	2.4	4.1	-1.7	0.3	-2.0
Leg predicted mass (left)	0.9	4.6	9.7	1.1	-1.7	3.1
Trunk fat mass	0.2	0.6	1.2	-0.6	-0.6	1.1
Waist circumference	0.2	0.7	2.0	-0.1	-0.2	1.4
Number of incorrect matches in round	1.6	2.7	6.9	-2.6	0.6	-0.9
Past tobacco smoking	0.1	0.1	0.3	0.5	-0.1	-0.2
Alcohol usually taken with meals	1.0	1.6	2.9	-0.8	1.1	-1.7
Nervous feelings	1.5	2.8	4.7	-2.2	1.8	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.0	-1.4	0.2	0.8
Hearing difficulty/problems with background noise	2.2	3.5	5.7	-2.2	2.4	0.3
Hair/balding pattern: Pattern 2	2.5	3.2	7.1	2.7	-1.6	0.2
Had menopause	0.1	0.1	0.3	-0.1	-0.3	0.5
Had other major operations	1.6	2.0	5.0	-1.0	-2.2	0.2
Forced vital capacity (FVC)	0.1	0.6	1.3	-0.7	-1.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.0	0.5	1.0	-0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	-0.2	0.4	0.8
Qualifications: None of the above	0.6	1.2	2.7	-1.0	-0.2	-1.6
Financial difficulties in last 2 years	2.1	2.8	5.3	-0.5	-1.6	2.3
Mouth/teeth dental problems	0.2	0.3	0.6	-0.5	0.7	-0.0
Heart attack	0.4	0.5	0.7	0.4	-0.9	-0.7
Allergy	0.3	0.7	1.9	-1.4	0.3	-0.5
Pain all over the body in last month	2.1	2.3	2.9	-1.7	1.0	1.7
Diabetes (self-reported)	0.2	0.3	0.4	0.5	0.5	-0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.4	1.5	-0.0	0.8
Medication: Ramipril	0.5	0.7	1.9	-0.1	1.4	-0.3
Medication: Simvastatin	0.1	0.2	0.4	0.7	0.2	0.0
Fluid intelligence score	0.5	1.0	2.1	0.4	-1.5	0.9
Illnesses of siblings	0.9	1.2	3.7	-0.0	0.2	1.9
Neuroticism score	0.7	1.4	3.9	-2.0	0.4	0.5
Weight	0.6	3.0	6.4	0.9	-1.4	2.5
Impedance of arm (right)	0.6	3.0	8.1	-0.7	-0.7	-2.9
Arm fat percentage (right)	0.0	0.2	0.5	-0.1	-0.7	0.3
Trunk fat-free mass	1.2	7.0	13.9	1.6	-2.1	3.7
Hip circumference	0.5	2.2	3.1	1.4	-1.8	1.3
Time employed in main current job	0.4	0.4	1.0	1.0	-0.2	-0.5
Alcohol intake versus 10 years previously	0.3	0.5	1.4	-0.0	-0.3	-1.2
Father’s age at death	0.7	0.9	1.4	-1.1	1.2	0.3
Worrier / anxious feelings	0.3	0.6	1.3	-1.1	0.4	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	-1.0	-0.7	0.2
Falls in the last year	0.7	1.0	2.3	-1.5	0.8	0.1
Hair/balding pattern: Pattern 3	1.4	2.1	3.8	-2.0	-0.3	1.6
Number of live births	0.4	0.5	1.5	-0.1	-1.2	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.1	-0.3	-0.2	0.2
Pulse rate	1.0	1.6	1.9	-1.4	-1.0	-1.4
Happiness	1.2	1.5	2.6	-1.6	-0.4	-1.3
Noisy workplace	1.0	1.2	2.5	0.4	1.6	-1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.7	1.3	-0.0	0.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.1	0.6	1.0	1.4
Mouth/teeth dental problems: Dentures	0.9	1.5	2.5	0.2	-1.6	-1.4
Asthma	0.8	1.6	3.3	0.9	-0.8	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	0.3	0.0	1.2
Medication: Cholesterol lowering	0.7	1.1	2.0	1.4	-1.0	-0.7
Depression (self-reported)	0.5	0.6	0.7	0.9	-0.6	-0.7
Medication: Lansoprazole	0.6	0.7	1.3	-0.8	1.1	-0.5
Prospective memory result	0.5	0.6	0.9	-0.3	-1.0	-0.9
Lung cancer (father)	0.4	0.5	1.3	-0.3	-0.5	-1.1
Illnesses of mother	0.2	0.2	0.4	0.1	0.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	-0.6	-0.2	-0.6
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	1.1	-0.2	0.5
Impedance of arm (left)	0.7	3.3	9.1	-1.0	0.0	-3.0
Arm fat mass (right)	0.2	1.0	1.9	0.2	-1.0	1.4
Trunk predicted mass	1.2	6.8	13.3	1.6	-2.2	3.6
Standing height	0.4	4.1	6.8	0.5	-2.3	2.6
Length of working week for main job	0.3	0.4	0.6	0.7	-0.1	0.7
Exposure to tobacco smoke at home	0.5	0.6	1.3	-0.6	0.0	1.2
Breastfed as a baby	1.0	1.2	2.3	-1.5	-1.1	0.1
Tense / ‘highly strung’	1.9	3.1	5.0	-2.1	2.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	-0.2	-1.3	0.1
Hair/balding pattern: Pattern 4	1.0	2.5	5.8	-1.1	-0.6	-2.4
Birth weight of first child	0.5	0.9	2.7	-0.3	1.6	-0.1
Peak expiratory flow (PEF)	1.1	2.7	5.1	-1.4	1.0	2.3
Pulse wave reflection index	1.1	1.4	3.1	-0.7	0.7	1.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.7	-0.2	1.3	0.6
Loud music exposure frequency	0.4	0.5	0.9	1.0	0.1	0.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.2	1.5	-0.7	0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	0.2	-0.1	0.8
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.1	-0.2	0.1
Medication: Paracetamol	0.4	0.7	1.7	-0.7	-0.1	-1.3
Headache pain in last month	1.6	2.7	8.0	-0.2	-2.8	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	-0.1	0.2	0.8
Glaucoma (self-reported)	0.6	0.7	1.4	-0.8	-0.2	-1.2
Gout (self-reported)	1.0	1.4	2.9	1.7	-1.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.1	-0.0	-1.1
Medication: Amlodipine	0.9	1.3	3.4	-0.2	0.7	-1.8
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.1	1.1	0.2	1.1
Birth weight	0.8	1.8	5.1	2.3	0.2	0.6
Chronic bronchitis/emphysema (mother)	1.8	2.1	4.2	-0.4	-2.0	-1.4
High blood pressure (siblings)	0.1	0.2	0.3	-0.4	0.5	-0.2
Forced vital capacity (FVC), Best measure	0.4	1.3	1.9	-1.4	-1.1	-0.8
Body fat percentage	0.1	0.4	1.1	-1.0	-0.2	0.1
Leg fat percentage (right)	0.0	0.0	0.1	-0.1	-0.1	-0.3
Arm fat-free mass (right)	1.3	6.6	18.2	0.7	-1.0	4.3
Exposure to tobacco smoke outside home	2.4	3.2	4.4	-1.5	2.1	-1.7
Comparative body size at age 10	0.4	1.1	3.3	-0.1	-0.1	1.8
Number of full brothers	0.6	0.7	1.1	1.1	-0.6	0.9
Worry too long after embarrassment	0.7	1.1	1.8	-0.6	1.1	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.9	-0.1	0.5
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.2	-0.1	-0.4
Number of children fathered	0.4	0.5	0.9	-0.2	-0.7	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	1.8	0.8	-1.3	1.1
Age at first live birth	0.9	1.7	4.1	-0.3	2.0	0.9
Pulse wave peak to peak time	0.3	0.4	1.0	-1.0	0.0	-0.2
Health satisfaction	0.9	1.2	2.9	0.7	1.7	-0.4
Shortness of breath walking on level ground	0.4	0.5	1.4	1.2	-0.3	0.2
Qualifications: College or University degree	0.5	1.5	2.8	-1.3	0.1	1.7
Eye problems/disorders: None of the above	1.5	1.7	2.3	1.5	-1.4	1.0
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.3	1.1	1.0	0.7
Emphysema/chronic bronchitis	0.6	0.6	0.7	-0.7	0.8	-0.8
Medication for pain relief, constipation, heartburn	1.0	1.7	2.5	0.9	1.3	1.6
Neck or shoulder pain in last month	0.8	1.1	2.2	0.9	-0.6	-1.5
Medication: Blood pressure	0.0	0.1	0.2	0.1	-0.5	-0.1
Angina (self-reported)	0.4	0.6	1.3	-0.3	-0.6	-1.1
Migraine (self-reported)	0.2	0.3	0.6	0.8	-0.3	-0.5
Medication: Ibuprofen	0.2	0.2	0.6	0.3	0.2	0.8
Medication: Allopurinol	0.5	0.7	1.3	1.2	-0.9	-0.0
Medication: Omeprazole	0.7	0.9	1.3	0.8	-1.1	-0.8
Medication: Seretide 50 evohaler	0.5	0.6	1.3	-1.1	-0.6	-0.3
Mean time to correctly identify matches	0.1	0.1	0.3	0.2	0.6	0.1
Heart disease (mother)	0.7	0.9	1.7	0.9	-1.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.5	-0.2	1.5	1.9
Whole body fat mass	0.2	0.8	1.6	-0.3	-0.8	1.2
Leg fat mass (right)	0.2	0.8	1.8	0.1	-0.8	1.4
Arm predicted mass (right)	1.1	5.7	16.4	0.3	-0.8	4.0
Pulse rate, automated reading	1.0	3.3	6.0	-1.7	-0.9	-2.5
Alcohol intake frequency.	0.1	0.2	0.3	0.5	0.6	-0.4
Comparative height size at age 10	0.3	1.5	2.6	1.0	-0.9	1.6
Number of full sisters	0.2	0.3	0.4	-0.1	-0.6	-0.6
Suffer from ‘nerves’	2.2	3.5	8.5	-2.9	1.3	-0.5
Overall health rating	0.9	2.0	4.0	-0.1	-1.4	-2.0
Chest pain or discomfort	1.4	2.0	3.9	1.1	1.0	-2.0
Had major operations	0.3	0.4	0.6	-0.6	0.4	-0.8
Age at last live birth	1.6	2.3	5.1	-1.1	0.8	2.3
Family relationship satisfaction	0.6	0.7	1.1	-1.1	0.0	-1.1
Leg pain on walking	0.6	0.7	1.9	1.4	0.5	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	0.4	0.4	-1.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.5	0.3	0.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	1.8	-1.0	1.2	-1.3
Medication: Aspirin	0.5	0.6	0.8	-0.5	-0.9	-0.9
Supplements: Vitamin C	0.1	0.2	0.3	-0.0	0.5	0.5
Knee pain experienced in last month	0.3	0.4	0.8	0.5	-0.3	-0.9
Hypertension (Self-reported)	0.3	0.8	1.2	0.7	0.8	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	0.0	-0.1	-0.8
Illnesses of father: Heart disease	1.9	2.7	8.0	-2.8	0.1	0.2
Illnesses of siblings: Diabetes	1.4	1.7	4.5	-0.7	-0.3	-2.1
Smoking status: Previous	0.4	0.6	1.6	-0.4	0.2	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	5.6	0.7	-0.1	2.4
Whole body fat-free mass	1.1	6.5	14.1	1.5	-1.9	3.8
Leg fat-free mass (right)	0.9	4.8	11.3	1.0	-1.5	3.4
Arm fat percentage (left)	0.0	0.1	0.1	-0.3	-0.3	0.2
Average weekly red wine intake	1.5	2.2	4.3	-1.1	2.1	-1.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.4	-1.2	-0.1	1.0
Mood swings	0.5	1.0	1.6	0.2	-1.3	1.1
Loneliness, isolation	0.8	1.2	2.7	-1.6	0.8	0.2
Long-standing illness, disability or infirmity	1.2	1.9	2.4	1.2	-1.3	-1.6
Ever had bowel cancer screening	0.6	0.7	2.0	0.0	-0.1	1.4
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.3	0.0	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.0	0.3	-1.4	-1.4
Friendships satisfaction	1.9	2.3	6.9	-2.6	-0.2	-0.1
Qualifications: nursing, teaching	0.9	1.5	3.3	-0.3	1.0	1.8
Commuting to job workplace: Walk	1.1	1.1	3.1	-0.6	0.0	1.8
Eye problems/disorders: Cataract	1.7	1.9	3.5	-1.9	1.4	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.0	-0.0	-1.1	1.4
Medication for cholesterol	1.0	1.5	4.5	0.1	0.3	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	2.8	-1.5	-1.2	-1.7
Back pain experienced in last month	0.7	1.0	2.8	-0.2	-0.4	-1.7
Mineral and other dietary supplements	0.4	0.6	1.6	-0.2	-0.2	-1.3
Breast cancer (self-reported)	0.1	0.1	0.4	0.1	0.6	0.2
Asthma (self-reported)	0.8	1.6	2.4	1.1	-1.0	1.5
Osteoporosis (self-reported)	0.3	0.3	1.0	0.0	-1.0	-0.1
Osteoarthritis (self-reported)	0.9	1.2	3.2	0.5	-1.8	0.0
Medication: Aspirin	0.2	0.3	0.6	-0.5	-0.2	-0.8
Medication: Gliclazide	0.2	0.2	0.5	-0.2	-0.2	-0.7
Illnesses of father: None of the above (group 1)	1.5	1.8	4.4	2.1	-0.7	-0.7
Smoking status: Current	3.0	4.7	6.5	1.1	-2.5	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.2	-0.3	0.8
Whole body water mass	1.1	6.5	14.5	1.4	-1.8	3.8
Leg predicted mass (right)	0.9	4.6	10.9	1.0	-1.4	3.3
Arm fat mass (left)	0.3	1.1	2.5	0.2	-0.8	1.6
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.5	-0.1	-0.3
Average weekly champagne plus white wine intake	1.8	2.5	4.8	1.6	-0.4	2.2
Miserableness	1.3	2.2	6.1	-2.5	-0.4	0.5
Guilty feelings	0.7	1.0	2.1	-1.4	-0.1	1.0
Wears glasses or contact lenses	1.8	2.1	4.9	-0.3	1.1	-2.2
Ever taken oral contraceptive pill	0.4	0.4	1.1	-0.4	-1.1	0.1
Hearing aid user	0.2	0.2	0.3	0.5	-0.1	-0.5
Mother’s age at death	0.7	0.8	1.3	-0.0	-1.1	1.1
Financial situation satisfaction	0.4	0.5	0.9	0.9	-0.5	-0.5
Tinnitus: Yes, now most or all of the time	1.8	2.1	3.5	-0.1	-1.6	-1.9
Commuting to job workplace: Public transport	1.4	1.6	2.6	1.6	-0.6	-1.4
Eye problems/disorders: Glaucoma	0.9	1.1	2.0	-1.4	0.0	-1.1
Medication: Blood pressure	0.5	0.9	2.1	-0.6	0.5	-1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.3	-0.7	-0.2	-1.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	0.7	-0.9	0.1
High cholesterol (Self-reported)	0.4	0.7	1.2	1.1	-0.4	-0.9
Medication: Bendroflumethiazide	1.1	1.6	1.9	-1.1	-1.4	-1.3
Medication: Paracetamol	0.9	1.3	3.1	-0.4	-0.8	-1.8
Medication: Lisinopril	0.1	0.2	0.5	0.2	0.1	-0.7
Medication: Atorvastatin	0.7	0.9	1.9	0.7	-1.4	0.5
Illnesses of father: High blood pressure	0.7	0.8	2.4	-1.6	-0.1	-0.2
Alcohol drinker status: Never	0.9	1.0	2.1	-1.5	0.9	-0.2
Ever smoked	0.2	0.3	0.9	-1.0	-0.2	-0.2
Basal metabolic rate	1.0	5.7	12.5	1.2	-1.8	3.5
Leg fat percentage (left)	0.1	0.2	0.6	-0.8	0.2	0.1
Arm fat-free mass (left)	1.3	6.6	17.2	0.7	-1.4	4.2
Number of operations (self-reported)	1.0	1.5	3.4	0.7	-1.8	0.8
Average weekly beer plus cider intake	0.7	0.9	1.4	0.5	1.2	-1.1
Irritability	0.2	0.4	0.9	-0.0	0.5	1.0
Risk taking	0.4	0.5	1.3	-0.6	-1.1	-0.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.5	-0.9	1.1	-1.6
Fractured/broken bones in last 5 years	0.7	0.9	2.4	1.5	0.1	0.6
Age started oral contraceptive pill	1.1	1.3	2.6	1.1	1.6	-0.5
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	0.6	0.4
Ever depressed for a whole week	2.1	2.6	3.5	1.9	1.0	1.7
Unable to work because of sickness or disability	0.9	1.1	2.2	0.9	0.6	-1.5
Commuting to job workplace: Cycle	1.2	1.5	4.2	-2.1	0.3	0.4
Myopia	1.0	1.4	4.1	0.4	-0.0	2.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.1	0.0	-1.1	1.0
Cholesterol lowering medication	0.4	0.5	1.6	-0.0	1.3	0.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.1	1.2	-0.9	-1.4
Pain experienced in last month	1.1	1.8	4.0	-0.6	2.0	1.0
Supplements: Calcium	0.1	0.1	0.2	-0.3	0.0	0.4
Basal cell carcinoma (self-reported)	1.6	1.9	5.1	0.6	-0.2	2.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.1	0.4	-1.0	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.1	-0.5	-0.4
Heart disease (siblings)	2.2	2.7	5.6	0.0	-1.6	-2.4
Alcohol drinker status: Previous	0.3	0.4	0.5	0.5	-0.7	0.6
Pack years of smoking	0.6	0.9	1.4	-0.2	-1.2	-1.2
Impedance of whole body	0.7	3.3	8.1	-1.3	0.3	-2.9
Leg fat mass (left)	0.3	1.1	2.8	-0.1	-0.6	1.7
Arm predicted mass (left)	1.4	7.2	19.1	0.9	-1.3	4.4