TWAS hub - ZHX2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.208	0.0240	0.0e+00	0.198	0.148	0.200	0.190	0.201	7.5e-62	2.4e-45	2.6e-62	5.2e-59	6.8e-63
2	ROSMAP	Brain Pre-frontal Cortex	0.185	0.0423	8.1e-07	0.075	0.055	0.078	0.073	0.072	6.0e-10	1.2e-07	2.9e-10	1.2e-09	1.4e-09
3	YFS	Blood	0.305	0.0311	0.0e+00	0.222	0.224	0.254	0.253	0.252	3.9e-71	7.6e-72	1.1e-82	4.8e-82	8.8e-82
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.168	0.0680	7.5e-03	0.098	0.001	0.017	NA	0.072	3.0e-06	2.8e-01	3.5e-02	NA	5.9e-05
5	TCGA	Stomach Adenocarcinoma	0.096	0.0410	4.9e-03	0.014	0.025	0.014	NA	0.005	3.3e-02	6.1e-03	3.1e-02	NA	1.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Length of working week for main job	6.2	6.9	11.3	3.0	1.5	-2.7	-3.4	-2.1
Comparative height size at age 10	5.7	31.2	73.4	8.6	1.6	-8.3	-1.8	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	5.2	10.8	26.1	5.1	0.2	-5.1	-0.5	-1.3
Forced expiratory volume in 1-second (FEV1)	4.2	14.0	34.5	5.7	-0.6	-5.9	-0.3	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	4.2	13.3	32.2	5.6	-0.2	-5.7	-0.6	-1.7
Supplements: Zinc	4.1	4.4	8.2	-2.5	-1.3	2.4	0.8	2.9
Sitting height	4.1	28.8	72.1	8.5	0.5	-7.9	0.1	-3.0
Forced vital capacity (FVC)	4.1	15.9	38.1	6.2	-0.5	-6.1	-0.3	-1.9
Forced vital capacity (FVC), Best measure	4.1	14.9	35.3	5.8	0.2	-5.9	-0.7	-2.2
Peak expiratory flow (PEF)	3.9	9.1	24.5	4.5	-0.6	-5.0	-0.2	-0.6
Standing height	3.6	36.2	86.3	9.3	2.3	-8.7	-0.9	-3.6
Leg pain on walking	3.3	4.1	9.1	-3.0	-0.8	3.0	0.4	1.4
Knee pain experienced in last month	3.2	4.9	7.1	-2.7	-2.3	2.6	-0.6	2.2
High blood pressure (mother)	3.1	4.3	9.1	-2.6	-0.7	3.0	1.3	1.8
Ever had hysterectomy (womb removed)	3.0	3.4	7.6	1.2	2.8	-1.0	0.5	-2.6
Other serious medical condition/disability diagnosed by doctor	2.9	3.7	7.5	2.0	1.5	-2.1	-2.7	-0.9
Systolic blood pressure, automated reading	2.9	8.6	20.3	-4.3	-1.4	4.5	0.4	1.4
Trunk fat-free mass	2.9	16.9	44.1	6.6	-0.4	-6.0	-0.4	-1.9
Trunk predicted mass	2.9	16.8	44.0	6.6	-0.5	-6.0	-0.4	-1.9
Height	2.8	53.2	118.8	10.9	2.6	-10.8	-1.1	-4.7
Supplements: Glucosamine	2.8	3.7	6.3	-2.5	0.1	2.4	0.8	2.4
Illnesses of mother	2.8	3.4	8.4	2.7	0.5	-2.9	-0.4	-1.0
Mean Putamen Volume	2.5	2.8	7.6	1.6	2.8	-1.6	-0.2	-1.1
Pulse wave Arterial Stiffness index	2.5	2.9	6.0	2.1	0.3	-1.9	0.4	-2.5
Arm fat-free mass (left)	2.4	12.1	31.4	5.6	-0.8	-5.0	-0.6	-1.8
Medication: Ibuprofen	2.3	2.8	5.6	-1.8	-1.7	1.5	0.4	2.4
Whole body fat-free mass	2.3	13.3	35.2	5.9	-0.6	-5.3	-0.3	-1.6
Whole body water mass	2.3	13.0	34.2	5.8	-0.7	-5.3	-0.3	-1.6
Arm predicted mass (left)	2.3	11.5	30.2	5.5	-1.0	-4.9	-0.4	-1.5
Alzheimer’s Disease (in mother)	2.2	2.6	5.2	-2.0	-0.6	2.3	1.8	0.4
Average weekly fortified wine intake	2.2	2.6	4.2	2.1	0.1	-1.8	-1.1	-2.0
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	6.2	2.5	0.3	-2.4	0.0	-1.0
Arm fat-free mass (right)	2.2	11.5	30.0	5.5	-1.1	-4.9	-0.4	-1.5
Alzheimer’s Disease (including proxy)	2.1	3.1	6.2	-2.4	-0.2	2.5	1.7	0.9
Basal metabolic rate	2.1	11.6	30.7	5.5	-0.8	-4.9	-0.4	-1.4
Alcohol drinker status: Previous	2.1	2.4	3.6	1.5	1.8	-1.6	0.6	-1.9
Time employed in main current job	2.0	2.3	3.9	-1.9	-1.9	2.0	0.3	-0.5
Arm predicted mass (right)	2.0	10.4	27.7	5.3	-0.9	-4.6	-0.5	-1.2
Major Depression (MDD)	1.9	2.4	3.7	1.4	1.9	-1.8	-1.7	-0.2
Happiness	1.9	2.3	7.9	1.0	-1.4	-0.8	2.8	-0.3
Breastfed as a baby	1.9	2.4	5.1	1.7	1.4	-1.3	0.4	-2.3
Pulse wave reflection index	1.9	2.4	5.4	2.3	-0.3	-2.2	0.5	-1.2
Wheeze or whistling in the chest in last year	1.9	3.4	7.9	-2.7	0.0	2.8	-0.4	1.2
Pulse wave peak to peak time	1.9	2.3	5.4	-1.7	-0.5	1.6	-0.5	2.3
HDL Cholesterol	1.8	3.0	5.0	-2.2	-1.4	2.2	0.8	1.6
Townsend deprivation index at recruitment	1.8	2.5	5.0	-1.8	-0.2	2.0	2.2	0.3
Medication: Atenolol	1.8	2.2	4.6	-1.4	-0.6	1.5	1.3	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.7	-1.5	2.4	1.7	-0.7	-1.6
Illnesses of father: High blood pressure	1.8	2.2	4.4	-1.3	1.5	1.6	2.1	-0.4
Pain experienced in last month	1.8	3.1	5.8	2.2	0.7	-2.4	-0.6	-2.0
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.6	-1.4	-0.9	1.3	1.3	1.9
Alcohol intake frequency.	1.7	3.8	8.3	2.2	1.7	-2.9	0.6	-1.7
Supplements: Vitamin C	1.7	2.0	5.9	-1.1	-0.1	1.4	0.9	2.4
Average weekly red wine intake	1.7	2.5	6.7	-0.7	-2.1	0.8	-0.4	2.6
Schizophrenia (2018)	1.6	3.3	12.5	1.2	1.3	-0.5	3.5	-0.8
Ulcerative Colitis (UC)	1.6	3.1	9.2	-1.6	0.6	1.5	-3.0	1.1
Systolic Blood Pressure	1.6	7.9	18.6	-4.0	-1.1	4.3	1.8	0.4
Medication: Co-codamol	1.6	1.8	4.9	-2.0	0.2	2.2	0.3	-0.1
Leg predicted mass (right)	1.6	8.3	22.2	4.7	-0.8	-4.2	-0.2	-1.0
Unable to work because of sickness or disability	1.6	2.0	5.8	-1.5	2.4	1.2	-0.5	-0.5
Primary Biliary Cirrhosis	1.5	2.1	5.2	-1.7	2.3	0.8	-1.3	-0.4
Angina	1.5	2.0	3.1	-1.8	-0.6	1.6	1.0	1.7
Leg fat-free mass (left)	1.5	7.8	20.8	4.6	-0.5	-4.0	-0.1	-1.3
Leg predicted mass (left)	1.5	7.7	20.5	4.5	-0.6	-4.1	-0.0	-1.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	6.4	0.4	0.3	-0.3	-1.6	-2.5
Leg fat-free mass (right)	1.5	8.1	21.7	4.7	-0.9	-4.1	-0.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.2	-1.5	-0.9	1.1	-0.5	2.1
Mineral and other dietary supplements	1.4	1.9	3.6	1.9	0.3	-1.4	-0.6	-1.8
Medication: Bendroflumethiazide	1.4	2.1	6.1	-1.1	-2.5	0.9	0.8	1.4
Commuting to job workplace: Cycle	1.4	1.7	2.7	-1.6	-1.5	1.7	0.9	0.3
Pack years of smoking	1.4	2.1	5.0	-1.2	2.2	1.3	1.1	-1.1
Neuroticism (2016)	1.3	1.9	4.0	1.0	2.0	-1.1	0.5	-1.8
Ulcerative Colitis	1.3	1.9	3.9	-2.0	0.4	1.8	-1.2	0.8
Blood White Count	1.3	9.6	20.2	-4.5	-0.8	4.4	1.3	2.5
Medication for hormone replacement therapy	1.3	1.4	2.8	-1.2	-1.7	0.9	1.4	0.5
Financial difficulties in last 2 years	1.3	1.7	3.9	1.6	-1.3	-2.0	0.0	0.6
Medication: Blood pressure	1.3	2.3	6.3	-0.8	-1.8	0.8	0.8	2.5
Average weekly champagne plus white wine intake	1.3	1.8	6.3	-0.8	0.8	1.2	-2.5	-0.0
Irritable Bowel Disease (IBD)	1.2	2.8	5.9	-1.6	0.8	1.4	-2.4	1.7
Hand grip strength (right)	1.2	3.3	8.9	3.0	-0.1	-2.6	0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.5	1.4	-1.9	-1.5	-0.1	0.1
Weight	1.2	5.8	15.2	3.9	-1.4	-3.4	-0.3	-0.7
Medication: Lansoprazole	1.2	1.4	1.9	1.3	1.2	-1.1	-0.9	-1.4
Birth weight	1.2	2.5	5.6	2.4	-1.4	-2.0	1.0	-0.4
Shortness of breath walking on level ground	1.2	1.4	2.4	-1.4	0.3	1.6	0.9	-1.4
Neck or shoulder pain in last month	1.2	1.7	3.0	-1.6	1.1	1.3	-1.7	-0.0
Angina (self-reported)	1.2	1.6	2.8	-1.5	-0.6	1.4	0.9	1.7
Chest pain or discomfort	1.2	1.8	3.6	-1.1	1.1	1.2	1.9	-1.2
Handedness (chirality/laterality): Left-handed	1.2	1.4	6.5	-0.0	0.8	-0.0	2.5	0.0
Pain type(s) experienced in last month: Hip pain	1.2	1.6	3.6	-1.0	1.5	0.9	-1.9	-0.2
Alzheimer’s Disease (in father)	1.1	1.2	1.8	-0.9	1.3	1.1	1.1	1.0
Breast Cancer	1.1	2.7	6.3	-1.7	-1.4	1.5	0.5	2.5
Hypothyroidism (self reported)	1.1	2.6	5.8	2.1	-0.8	-2.4	1.0	-1.0
Current tobacco smoking	1.1	1.9	4.9	-1.3	-0.4	1.4	2.2	0.8
Nervous feelings	1.1	2.1	6.2	-1.0	1.4	1.2	-0.1	-2.5
Had other major operations	1.1	1.4	2.6	-1.6	1.0	1.6	0.1	0.9
Pain all over the body in last month	1.1	1.1	2.8	-1.3	0.7	0.8	1.7	0.3
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	5.6	1.0	1.1	-1.2	-0.4	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.9	0.1	2.0	-0.3	0.1	-1.7
Had major operations	1.1	1.3	4.2	0.3	-2.0	-0.5	-0.8	1.2
Family relationship satisfaction	1.1	1.3	3.1	1.8	0.0	-1.4	1.1	-0.5
Long-standing illness, disability or infirmity	1.1	1.7	2.9	-1.1	1.5	0.9	-1.7	-1.2
Eye problems/disorders: Cataract	1.1	1.3	2.7	-0.6	1.2	0.9	-1.1	-1.6
Back pain experienced in last month	1.1	1.6	3.7	-1.7	0.8	1.9	0.7	-0.5
Smoking status: Current	1.1	1.7	4.9	-1.0	-0.1	1.5	2.2	0.4
Wears glasses or contact lenses	1.1	1.3	2.6	-1.1	1.6	1.2	0.9	0.5
Medication: Blood pressure	1.1	2.0	3.8	-1.5	-0.9	1.4	1.9	1.2
Schizophrenia (2014)	1.0	2.2	6.9	0.8	1.6	-0.3	2.6	-0.8
Waist Hip Ratio (WHR)	1.0	4.6	10.1	2.6	1.4	-3.2	-1.3	-1.6
Number of treatments/medications taken	1.0	1.7	3.3	-1.8	-0.1	1.3	1.1	1.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.2	0.8	-1.5	-0.5	0.6	1.3
Pack years adult smoking proportion	1.0	1.5	4.0	-0.9	2.0	1.0	1.1	-0.8
Number of incorrect matches in round	1.0	1.6	3.5	-1.4	1.9	1.4	-0.2	0.7
Mouth/teeth dental problems: Dentures	1.0	1.6	2.9	-1.4	1.5	1.7	-0.6	-0.8
Tense / ‘highly strung’	1.0	1.7	3.9	1.3	0.2	-1.6	-0.0	-2.0
Hair/balding pattern: Pattern 4	1.0	2.4	4.6	2.1	0.9	-2.2	-1.4	-0.2
Age at first live birth	1.0	1.8	3.8	1.9	1.0	-1.9	0.3	0.7
Illnesses of father: Heart disease	1.0	1.4	5.5	0.6	0.8	-0.4	-0.6	-2.4
Ever had bowel cancer screening	1.0	1.1	2.9	-1.1	-0.3	1.1	0.2	1.7
Medication for cholesterol	1.0	1.5	2.2	1.5	0.9	-1.3	-1.4	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.1	0.4	1.3	-0.4	1.4	-1.4
Illnesses of father: None of the above (group 1)	1.0	1.2	2.9	1.7	-0.4	-1.5	-0.7	0.5
Myopia	1.0	1.5	5.8	-0.6	1.0	0.4	2.4	-0.3
Lupus	0.9	1.3	3.7	-0.2	-1.9	0.4	1.6	0.4
Lung FVC	0.9	4.6	10.8	3.3	0.9	-2.9	0.6	-1.4
Past tobacco smoking	0.9	1.6	6.9	-0.5	2.6	0.3	-0.1	-0.8
Birth weight of first child	0.9	1.6	2.6	1.2	-1.1	-1.3	-1.6	1.0
Blood clot in the leg (DVT)	0.9	1.1	2.4	-1.3	-1.1	1.5	0.5	0.2
Heart disease (mother)	0.9	1.1	2.7	-1.6	-0.1	1.6	0.1	-0.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.5	-1.5	0.3	1.6	-0.6	0.0
Smoking status: Previous	0.9	1.3	5.0	0.6	-2.2	-0.7	-0.2	0.8
Risk taking	0.9	1.3	2.8	0.2	1.7	0.2	-0.9	-1.7
Ever depressed for a whole week	0.9	1.1	2.4	-0.1	1.3	0.2	-1.5	-1.1
Vascular/heart problems diagnosed by doctor	0.9	2.4	3.3	1.6	1.1	-1.6	-1.5	-1.8
Bipolar Disorder or Schizophrenia	0.8	2.0	5.7	0.6	1.9	-0.2	2.4	-0.7
Schizophrenia vs Biploar Disorder	0.8	1.1	2.6	-0.6	-1.1	0.3	1.6	1.2
Rheumatoid Arthritis	0.8	1.1	2.6	1.4	-0.8	-1.6	0.2	0.3
Blood Platelet Count	0.8	9.5	24.0	-4.9	-0.5	4.6	-0.9	1.0
Hearing difficulty/problems: Yes	0.8	1.2	2.5	-1.6	0.1	1.1	-0.8	1.4
Relative age of first facial hair	0.8	1.6	2.6	-0.5	-1.6	0.3	1.6	1.6
Diabetes (mother)	0.8	1.0	1.7	1.3	-1.3	-1.1	-0.7	-0.1
Relative age voice broke	0.8	1.2	2.1	-1.4	-1.3	1.0	-0.8	0.6
Taking other prescription medications	0.8	1.3	3.4	-0.3	1.6	0.0	-0.4	-1.8
Multivitamins +/- minerals	0.8	1.1	1.8	-1.0	-1.3	0.9	0.6	1.2
Hearing difficulty/problems with background noise	0.8	1.2	4.0	-2.0	0.5	1.2	-0.1	0.8
Alcohol intake versus 10 years previously	0.8	1.2	2.5	1.0	-1.6	-1.4	0.6	-0.3
Noisy workplace	0.8	1.0	3.6	-0.8	-1.9	0.8	-0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.6	0.8	-1.4	0.0	1.2	1.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.9	1.2	-1.1	-1.4	-0.8	0.0
Exposure to tobacco smoke outside home	0.8	1.0	1.8	-0.9	1.3	1.3	0.0	-0.9
Worry too long after embarrassment	0.8	1.3	2.1	-1.1	1.4	1.5	-1.1	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.2	0.6	0.1	-0.9	-1.8	-0.5
Suffer from ‘nerves’	0.8	1.2	3.1	-1.0	0.5	1.1	0.7	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.9	0.3	-1.1	-0.3	0.7	1.7
Medication: Gliclazide	0.8	0.9	2.7	-0.2	-1.2	0.4	-0.3	1.7
Hearing aid user	0.8	0.9	2.6	-1.6	-0.1	1.2	-0.8	0.1
Medication: Paracetamol	0.8	1.3	3.0	-0.8	-1.2	1.1	0.2	1.7
Fractured/broken bones in last 5 years	0.8	1.0	2.5	-1.6	0.8	1.3	0.4	0.4
Diastolic blood pressure, automated reading	0.8	2.4	5.3	-1.6	-1.8	2.3	-0.4	0.7
Worry (Nagel 2018)	0.7	1.4	5.6	-0.9	0.2	0.8	0.3	-2.4
Prostate Cancer	0.7	1.0	1.7	-1.3	0.7	1.0	-0.8	1.1
Body Mass Index (BMI) (2010)	0.7	1.0	1.9	0.2	-1.3	0.1	1.0	1.4
Triglycerides	0.7	1.1	3.2	0.8	-0.3	-1.2	-1.8	-0.3
Neuroticism	0.7	1.7	5.3	-1.0	1.0	1.1	0.4	-2.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	-0.2	1.2	0.6	1.2	-1.1
Severe depression (siblings)	0.7	0.8	2.1	0.5	0.3	-0.5	1.5	-1.1
Maternal smoking around birth	0.7	1.0	2.4	-1.2	-1.5	1.0	-0.1	-0.2
Qualifications: CSEs or equivalent	0.7	0.9	2.3	0.3	-1.0	-0.6	-1.5	0.7
Alcohol usually taken with meals	0.7	1.1	3.3	-0.6	-0.6	1.1	-0.6	1.8
Falls in the last year	0.7	1.0	1.4	1.0	0.9	-1.0	-1.0	-1.2
Hair/balding pattern: Pattern 3	0.7	1.1	3.9	-0.1	1.0	-0.3	0.6	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	0.8	0.9	-0.9	1.3	-0.6
Loud music exposure frequency	0.7	0.8	1.5	-0.9	-0.2	1.2	1.0	-0.7
Medication: Paracetamol	0.7	1.2	2.2	-1.0	-0.5	1.4	0.6	1.5
Medication: Amlodipine	0.7	1.0	3.2	-0.4	0.5	0.5	1.0	1.8
Osteoporosis (self-reported)	0.7	0.9	1.6	-1.0	0.1	1.3	1.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.5	1.4	0.4	-1.6	-0.4	-1.5
Miserableness	0.7	1.3	1.8	-1.3	-1.2	1.2	-1.3	-0.5
Financial situation satisfaction	0.7	0.9	2.4	-0.3	-1.3	0.6	1.5	-0.0
Ever smoked	0.7	1.2	4.9	-0.0	-2.2	0.1	0.2	1.0
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.6	1.6	0.8	-1.6	0.2	-1.1
Ovarian Cancer	0.6	0.8	2.2	1.1	-0.4	-1.5	0.3	-0.1
Coronary Artery Disease (CAD)	0.6	0.8	1.5	0.9	-0.1	-1.2	0.5	-1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.2	0.7	-1.5	-0.8	0.3	-0.4
BMI	0.6	3.4	9.6	-0.5	-3.1	0.9	0.0	2.5
Allergy or Eczema	0.6	1.7	2.8	1.4	0.9	-1.7	-1.7	-0.6
Chronotype (morning person)	0.6	1.4	2.2	-1.5	1.0	1.0	-0.8	1.4
Hand grip strength (left)	0.6	1.7	3.5	1.9	-0.6	-1.5	1.1	-0.9
Average weekly spirits intake	0.6	0.8	1.7	-1.2	-0.7	1.3	-0.2	-0.3
Sensitivity / hurt feelings	0.6	1.0	1.8	-1.4	0.5	1.3	0.2	-0.9
Age when periods started (menarche)	0.6	1.5	3.3	-1.6	0.8	1.8	-1.1	0.1
High blood pressure	0.6	1.8	2.3	-1.2	-1.2	1.3	1.5	1.5
Trunk fat mass	0.6	2.8	6.3	2.5	-1.5	-2.2	-0.5	-0.3
Had menopause	0.6	0.7	1.7	-0.0	1.2	-0.2	0.6	-1.3
Fluid intelligence score	0.6	1.2	3.1	1.6	0.1	-1.8	0.1	0.5
Gout (self-reported)	0.6	0.8	1.9	-0.5	-0.8	0.6	0.9	1.4
Qualifications: College or University degree	0.6	2.0	4.2	0.8	2.0	-0.5	-1.5	-1.6
Eye problems/disorders: None of the above	0.6	0.6	1.9	0.3	-0.5	-0.6	1.4	0.8
Age at last live birth	0.6	0.8	1.6	0.8	0.9	-1.3	-0.4	0.9
Hypertension (Self-reported)	0.6	1.7	3.2	-0.5	-1.3	0.6	1.8	1.7
Loneliness, isolation	0.6	0.9	2.0	0.8	1.0	-0.7	1.4	-0.5
Qualifications: nursing, teaching	0.6	1.0	1.8	0.9	1.3	-0.2	1.3	-0.7
Eye problems/disorders: Glaucoma	0.6	0.7	1.7	0.1	1.3	-0.2	-0.4	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.9	-1.1	-0.6	1.4	0.3	-0.2
Depression (Nagel 2018)	0.5	0.7	2.1	0.4	0.4	-0.3	1.4	-1.0
Smoking Status	0.5	1.1	3.4	0.1	-1.2	0.3	1.9	0.7
Respiratory disease	0.5	1.1	4.1	-0.8	2.0	0.7	-0.2	-0.3
Vitamin and mineral supplements	0.5	0.7	1.2	0.5	0.9	-0.6	-0.8	-1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.3	-0.5	-0.2	0.0	0.3	1.5
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.8	0.8	1.1	-1.1	-1.3	0.4
Stomach or abdominal pain in last month	0.5	0.6	1.8	-0.4	0.9	0.3	-1.3	0.3
Mouth/teeth dental problems	0.5	0.7	1.7	0.7	-1.3	-0.6	0.9	0.4
Medication: Ramipril	0.5	0.6	1.8	-0.1	-1.0	0.1	1.4	0.4
Neuroticism score	0.5	1.1	2.8	-1.0	0.1	1.1	-0.5	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.9	0.6	1.4	-1.0	0.5	-0.8
Number of live births	0.5	0.8	1.5	-1.2	0.3	1.1	-0.3	1.0
Medication: Cholesterol lowering	0.5	0.8	1.7	-1.0	-0.1	1.3	0.1	1.1
Glaucoma (self-reported)	0.5	0.6	1.7	0.5	0.5	-0.5	-0.8	-1.3
Medication: Allopurinol	0.5	0.7	1.3	-0.7	-1.1	1.2	0.1	0.6
Medication: Seretide 50 evohaler	0.5	0.6	0.9	-0.9	0.4	0.9	-0.3	1.0
Mean time to correctly identify matches	0.5	1.0	1.9	-1.3	0.6	1.4	0.7	-0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	0.4	-1.1	-0.4	-1.1	0.3
Ever taken oral contraceptive pill	0.5	0.6	1.8	0.9	0.0	-0.5	-1.3	-0.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.1	1.7	-0.6	-1.8	0.5	-0.3
Neuroticism (Nagel 2018)	0.4	0.8	2.7	-0.3	-0.3	0.6	1.0	-1.6
Crohns Disease (2017)	0.4	0.8	1.8	-0.6	0.0	0.6	-1.2	1.3
HbA1C	0.4	0.4	0.8	-0.6	-0.8	0.6	0.9	0.1
Cardiovascular Disease	0.4	1.2	3.0	-0.3	-1.1	0.5	1.7	1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	-0.9	0.5	0.4	-0.8	-0.9
Body mass index (BMI)	0.4	1.5	6.4	-0.2	-2.5	0.5	0.1	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	-0.4	-0.5	0.3	-0.9	-1.2
Qualifications: None of the above	0.4	0.8	1.9	-1.4	-1.1	0.8	-0.0	0.0
Asthma	0.4	0.9	2.2	-1.5	0.6	1.3	-0.4	0.3
Arm fat mass (right)	0.4	1.5	3.8	1.5	-1.9	-1.2	-0.1	0.3
Number of full brothers	0.4	0.5	0.7	-0.8	0.6	0.5	0.6	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.6	0.1	0.8	-0.0	-1.3	0.4
Health satisfaction	0.4	0.6	2.0	0.1	-0.1	0.1	1.4	-0.9
Whole body fat mass	0.4	1.8	3.8	1.9	-1.6	-1.6	-0.2	-0.1
Friendships satisfaction	0.4	0.5	1.6	0.2	-1.0	0.0	1.3	-0.0
Commuting to job workplace: Walk	0.4	0.4	1.2	-0.2	1.1	-0.0	0.2	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	-0.9	0.3	1.3	-0.0	0.8
Osteoarthritis (self-reported)	0.4	0.5	1.6	-0.0	-0.2	-0.4	-0.8	1.3
Arm fat mass (left)	0.4	1.8	3.6	1.9	-1.5	-1.7	-0.2	0.2
Guilty feelings	0.4	0.7	1.2	1.0	-0.9	-0.5	0.2	-1.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	0.5	0.8	-0.6	-1.0	-0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.7	-0.5	-0.6	0.2	0.3	1.3
Medication: Lisinopril	0.4	0.5	1.8	-0.3	-0.3	-0.3	-0.6	1.4
Alcohol drinker status: Never	0.4	0.5	1.9	0.4	1.4	0.0	0.3	-0.5
Leg fat percentage (left)	0.4	1.6	6.9	0.0	-2.6	0.2	-0.3	0.9
Average weekly beer plus cider intake	0.4	0.6	1.9	0.1	1.0	0.1	-0.3	-1.4
Irritability	0.4	0.7	3.3	-0.1	-1.8	0.2	-0.3	-0.5
Leg fat mass (left)	0.4	1.7	5.1	1.4	-2.3	-1.0	-0.4	0.4
Bipolar Disorder (2018)	0.3	0.5	1.8	-0.4	1.3	0.3	-0.6	-0.2
Depressed Affect (Nagel 2018)	0.3	0.7	1.6	0.2	-0.8	0.1	1.3	-1.0
Crohns Disease (2012)	0.3	0.5	2.0	-0.4	0.3	0.3	-1.4	0.0
Fasting Glucose	0.3	0.4	0.7	0.4	-0.9	-0.1	0.4	0.8
Blood Red Count	0.3	2.9	5.7	2.4	-0.3	-2.4	1.1	-1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.3	0.8	-0.4	-1.1	-0.5	0.5
Medication: Metformin	0.3	0.4	1.1	0.5	0.1	-0.8	-1.1	0.4
Waist circumference	0.3	1.2	2.5	1.6	-0.4	-1.5	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.4	0.4	-0.9	-0.2	-1.6	0.4
Medication: Simvastatin	0.3	0.4	0.7	-0.7	0.3	0.4	0.6	0.8
Impedance of arm (right)	0.3	1.4	6.4	-0.3	2.5	-0.2	-0.5	-0.3
Father’s age at death	0.3	0.4	1.0	0.2	0.7	-0.3	1.0	-0.5
Worrier / anxious feelings	0.3	0.6	0.8	-0.7	-0.7	0.8	-0.6	-0.9
Depression (self-reported)	0.3	0.4	1.1	0.2	1.0	-0.3	0.7	-0.3
Prospective memory result	0.3	0.3	0.9	-0.1	0.4	-0.1	0.7	-1.0
Impedance of arm (left)	0.3	1.4	6.5	0.0	2.5	-0.5	-0.7	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.3	-0.5	0.5	-0.0	-1.1	-0.4
Headache pain in last month	0.3	0.4	0.8	-0.8	-0.1	0.4	-0.8	0.9
Comparative body size at age 10	0.3	0.8	2.4	1.5	-0.5	-0.9	0.2	-0.7
Emphysema/chronic bronchitis	0.3	0.3	0.7	-0.3	0.9	0.3	0.7	0.2
Leg fat mass (right)	0.3	1.3	3.2	1.3	-1.8	-1.0	-0.5	0.3
Overall health rating	0.3	0.6	1.9	0.2	0.9	-0.1	-0.6	-1.4
Diabetes diagnosed by doctor	0.3	0.5	1.6	-0.2	-0.2	-0.3	-1.3	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.5	0.4	0.4	-0.8	0.5
Asthma (self-reported)	0.3	0.6	1.3	-1.2	0.4	1.0	-0.4	0.5
Medication: Aspirin	0.3	0.4	1.0	-0.8	-0.1	0.5	1.0	-0.4
High cholesterol (Self-reported)	0.3	0.6	1.3	-0.7	-0.5	0.8	1.1	0.5
Age started oral contraceptive pill	0.3	0.4	1.4	-0.4	0.2	0.5	-0.2	-1.2
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	0.4	-0.4	-0.7	0.3	0.9
Heart disease (siblings)	0.3	0.4	0.9	-0.9	0.9	0.5	-0.4	0.1
Reaction Time	0.2	0.4	1.1	-0.9	0.4	1.1	0.2	-0.2
Age at First Birth	0.2	0.3	1.1	0.1	-0.2	-0.0	-1.1	0.7
LDL Cholesterol	0.2	0.4	0.8	-0.5	-0.4	0.5	-0.9	0.5
Blood Eosinophil Count	0.2	1.3	2.7	-0.6	0.9	0.6	-1.7	-1.5
Lung FEV1/FVC ratio	0.2	1.0	2.3	-1.0	-0.5	1.1	1.5	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.5	-0.6	-0.4	0.8	-0.6
Diabetes (father)	0.2	0.3	0.7	-0.1	-0.7	-0.1	-0.8	0.3
Impedance of leg (right)	0.2	1.0	3.1	0.0	1.8	-0.4	-1.3	-0.4
Trunk fat percentage	0.2	0.7	1.7	0.8	-1.3	-0.8	-0.7	0.0
Fed-up feelings	0.2	0.4	1.6	-0.0	-1.3	0.2	-0.4	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	0.2	-0.0	-0.2	-0.3	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.8	-0.2	-0.5	0.0	-1.4	0.6
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.4	-0.4	0.4	0.4	0.6
Medication: Levothyroxine sodium	0.2	0.4	1.0	-0.1	-0.9	0.1	1.0	-0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	0.5	0.9	-0.4	0.4	-0.2
Heart attack	0.2	0.3	1.1	-0.0	-0.2	0.5	1.0	-0.5
Allergy	0.2	0.5	1.9	0.2	-0.5	-0.0	1.4	-0.6
Diabetes (self-reported)	0.2	0.2	0.9	0.0	0.2	-0.4	-0.9	0.3
Illnesses of siblings	0.2	0.2	1.1	0.2	-0.2	-0.0	1.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	0.8	0.1	-0.6	0.8	-0.9
Exposure to tobacco smoke at home	0.2	0.3	0.6	-0.3	0.3	0.4	-0.6	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	0.5	-0.8	-0.6	0.8	-0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	-0.9	-0.2	0.8	-0.0	0.3
Leg fat percentage (right)	0.2	0.7	3.4	-0.1	-1.8	0.2	-0.2	0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	-0.3	0.5	0.2	-0.9	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.9	-0.3	-0.8	-0.1	-0.4
Medication: Omeprazole	0.2	0.2	0.5	-0.7	0.5	0.2	-0.5	-0.3
Pulse rate, automated reading	0.2	0.8	1.1	1.0	-1.1	-0.9	-0.9	-0.1
Number of full sisters	0.2	0.2	0.4	0.3	0.2	-0.7	-0.1	-0.6
Medication: Aspirin	0.2	0.2	0.7	-0.4	0.3	0.1	0.3	-0.8
Mood swings	0.2	0.4	1.6	-0.3	-1.3	0.3	0.2	0.5
Breast cancer (self-reported)	0.2	0.2	0.8	0.2	-0.5	-0.2	0.9	-0.1
Medication: Atorvastatin	0.2	0.2	0.5	-0.7	0.2	0.6	-0.2	0.3
Number of operations (self-reported)	0.2	0.2	0.5	-0.6	-0.4	0.3	0.3	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.8	0.2	-0.9	0.0	-0.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.9	-0.6	0.2	0.1	-1.0	-0.3
Supplements: Calcium	0.2	0.3	0.7	0.3	-0.1	0.1	0.8	-0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	-0.4	-0.3	0.7	0.8	-0.4
Impedance of whole body	0.2	1.2	4.0	0.2	2.0	-0.6	-1.2	-0.4
Heel T-Score	0.1	0.7	3.3	-0.4	0.5	-0.2	-1.8	-0.2
Tanning	0.1	1.7	3.3	-0.9	-1.8	1.1	-1.2	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.6	0.2	-0.2	-0.1	0.8	-0.1
Impedance of leg (left)	0.1	0.7	2.1	0.1	1.0	-0.5	-1.5	0.2
Arm fat percentage (right)	0.1	0.4	1.9	-0.0	-1.4	0.2	0.1	0.4
Hip circumference	0.1	0.6	1.8	1.4	-0.5	-0.9	-0.1	-0.4
Pulse rate	0.1	0.2	0.7	-0.4	0.0	0.5	-0.8	0.2
Lung cancer (father)	0.1	0.1	0.2	-0.3	-0.1	0.2	0.4	0.4
High blood pressure (siblings)	0.1	0.1	0.2	-0.3	0.4	0.3	-0.4	-0.2
Body fat percentage	0.1	0.5	2.3	0.2	-1.5	-0.1	-0.3	0.3
Number of children fathered	0.1	0.1	0.2	-0.3	-0.2	0.4	0.3	0.5
Migraine (self-reported)	0.1	0.2	0.6	0.4	0.3	-0.1	0.7	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.0	0.5	-0.3	-0.6	0.1
Illnesses of siblings: Diabetes	0.1	0.2	0.5	-0.0	-0.7	-0.4	-0.3	0.2
Arm fat percentage (left)	0.1	0.5	2.3	0.1	-1.5	0.0	0.1	0.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	-0.6	0.4	0.3	-0.5	-0.2
Mother’s age at death	0.1	0.2	0.4	-0.3	-0.1	0.4	-0.4	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.3	0.1	0.2	0.2	0.5
Cholesterol lowering medication	0.1	0.2	0.3	-0.6	0.6	0.3	0.4	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.0
Hair Pigment	0.0	1.0	1.9	1.3	-0.0	-1.0	-0.6	-1.4

Hub : Genes

ZHX2

Models

Trait associations