Hub : Genes

ZKSCAN7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0770	0.0370	8.2e-04	0.043	NA	0.064	NA	0.050	0.0020	NA	2.1e-04	NA	9.5e-04
2	GTEx	Cells EBV-transformed lymphocytes	0.0920	0.0490	7.6e-03	0.023	NA	0.023	NA	0.016	0.0570	NA	5.9e-02	NA	9.9e-02
3	GTEx	Liver	0.1640	0.0840	5.0e-03	-0.011	NA	0.020	NA	-0.009	0.9200	NA	8.9e-02	NA	7.1e-01
4	GTEx	Ovary	0.1390	0.0740	3.9e-03	0.093	NA	0.011	NA	0.045	0.0027	NA	1.7e-01	NA	2.9e-02
5	GTEx	Whole Blood	0.0890	0.0340	3.8e-05	0.026	NA	0.044	NA	0.055	0.0018	NA	6.1e-05	NA	7.4e-06
6	METSIM	Adipose	0.0661	0.0264	1.5e-04	0.003	0.034	0.008	0.034	0.013	0.0890	6.2e-06	1.9e-02	7.2e-06	3.9e-03
7	ROSMAP	Brain Pre-frontal Cortex	0.0501	0.0270	4.0e-03	0.017	0.012	0.005	0.017	0.021	0.0028	1.0e-02	6.2e-02	2.8e-03	7.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.8	4.5	9.2	-3.0	-2.7	-0.6	-2.7	-1.5	-1.2	-2.0
Bipolar Disorder or Schizophrenia	0.8	1.9	5.5	-1.3	-1.9	0.8	-1.2	-0.5	-0.1	-2.3
Depressed Affect (Nagel 2018)	2.5	5.3	11.0	-2.5	-1.8	-0.6	-2.1	-3.3	-3.0	-1.6
Depression (Nagel 2018)	4.9	7.4	15.0	-3.5	-3.9	1.4	-3.3	-1.1	-3.2	-0.8
Intelligence (Savage-Jansen 2018)	2.1	6.5	9.9	3.1	2.1	0.3	2.6	3.1	2.6	2.8
Neuroticism (Nagel 2018)	3.9	9.3	16.9	-3.5	-2.3	0.3	-3.0	-4.1	-3.4	-3.1
Schizophrenia (2018)	0.4	0.8	1.8	0.8	-0.3	1.2	0.6	0.6	0.8	-1.4
Schizophrenia vs Biploar Disorder	1.6	2.1	5.5	2.3	1.5	0.5	2.1	0.8	1.4	0.3
Worry (Nagel 2018)	3.7	7.9	14.8	-3.2	-2.2	0.4	-2.8	-2.9	-2.9	-3.8
Alzheimer’s Disease (in mother)	2.2	2.5	4.5	2.0	1.5	0.5	1.8	1.4	2.1	1.1
Alzheimer’s Disease (in father)	0.3	0.3	2.0	0.1	0.0	-0.2	-0.3	1.4	0.2	0.4
Alzheimer’s Disease (including proxy)	1.3	1.8	5.8	0.5	0.0	0.1	0.1	2.4	1.6	2.0
Crohns Disease (2017)	0.3	0.7	4.1	-0.6	-0.1	-2.0	-0.3	-0.4	-0.2	-0.5
Irritable Bowel Disease (IBD)	0.3	0.8	3.9	-0.7	-0.2	-2.0	-0.4	-0.3	0.1	-1.0
Ulcerative Colitis (UC)	0.3	0.5	2.4	-0.3	0.1	-1.6	-0.0	0.3	0.3	-0.8
Major Depression (MDD)	3.5	4.3	8.8	-3.0	-2.3	1.7	-2.9	-1.5	-1.4	-0.7
Reaction Time	1.4	2.6	8.4	-1.3	-0.6	-1.7	-1.0	-2.9	-2.0	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.1	0.5	0.4	0.4	0.2	1.4	-0.2	1.0
Breast Cancer	0.9	2.1	4.8	-2.2	-1.4	0.4	-2.0	-1.1	-1.6	-0.1
Ovarian Cancer	0.7	0.9	4.6	-0.4	-0.7	-2.1	-0.4	0.5	-0.5	0.4
Prostate Cancer	0.4	0.6	2.1	-0.5	-0.3	-1.1	-0.2	-1.5	-0.5	-0.1
Age at First Birth	2.0	3.0	6.1	2.3	2.0	1.0	2.5	1.3	1.5	-0.6
Bipolar Disorder (2011)	1.5	1.4	4.8	-1.2	-1.0	-2.2	-1.0	-0.9	-0.8	-0.5
Body Mass Index (BMI) (2010)	1.7	2.3	6.3	-1.1	-0.5	-1.8	-0.7	-2.5	-1.9	-1.0
Coronary Artery Disease (CAD)	1.3	1.5	4.7	-1.2	-2.2	-0.9	-1.1	-0.9	-1.3	-0.3
Crohns Disease (2012)	1.4	2.2	12.2	0.3	0.2	-3.5	0.1	-0.5	-1.0	-1.3
Mean Putamen Volume	0.3	0.3	0.9	-0.5	-0.5	1.0	-0.3	-0.4	-0.6	-0.4
Fasting Glucose	2.6	3.1	4.9	-1.7	-2.1	-2.2	-1.9	-0.8	-2.2	-0.4
HbA1C	2.4	2.7	5.7	2.1	2.2	-1.0	2.4	-0.3	1.7	-0.3
HDL Cholesterol	0.8	1.4	6.9	0.2	-0.5	0.3	-0.1	2.6	0.2	1.6
LDL Cholesterol	0.9	1.4	2.3	1.5	1.3	-1.2	1.5	0.4	1.3	-0.2
Lupus	0.1	0.2	0.5	0.2	0.4	0.0	0.5	-0.7	0.1	0.5
Neuroticism (2016)	2.9	4.2	10.3	-2.3	-1.5	0.4	-2.1	-3.2	-1.0	-2.5
Primary Biliary Cirrhosis	0.4	0.6	1.6	0.6	0.9	-0.0	0.6	-0.7	-0.7	1.3
Rheumatoid Arthritis	1.0	1.4	2.2	1.3	1.0	-1.3	1.5	-1.1	0.7	-1.2
Schizophrenia (2014)	0.5	1.0	3.1	0.9	-0.2	1.8	0.6	1.0	1.0	-0.8
Triglycerides	0.9	1.4	2.9	0.9	1.3	-0.3	1.2	-1.7	1.6	0.6
Type 2 Diabetes (T2D) (2012)	1.5	1.7	5.2	1.0	1.5	-2.3	1.3	-1.2	-0.3	0.4
Ulcerative Colitis	1.8	2.6	5.3	-2.3	-2.2	-0.4	-2.3	-0.5	-0.6	-1.4
Blood Eosinophil Count	0.1	0.6	3.3	-0.1	0.0	-0.2	-0.3	1.0	-0.2	1.8
Blood Platelet Count	0.4	5.0	9.3	-2.6	-3.0	1.4	-3.0	-0.7	-2.5	0.9
Blood Red Count	0.1	1.4	3.5	-0.3	-0.8	-1.9	0.0	-1.1	-1.2	1.7
Blood White Count	0.2	1.4	4.5	-1.0	-0.1	0.2	-0.8	-2.1	-1.9	0.6
Heel T-Score	0.7	5.8	20.9	-1.9	-1.5	0.9	-1.8	-2.9	-1.0	-4.6
BMI	1.0	5.7	14.7	-0.5	0.4	-3.5	0.4	-3.8	-3.4	0.8
Height	0.1	1.0	5.6	0.1	0.2	0.0	0.0	1.0	0.6	-2.4
Waist Hip Ratio (WHR)	0.4	1.9	12.2	0.1	0.5	0.3	0.1	-0.3	0.9	-3.5
Systolic Blood Pressure	0.1	0.7	2.1	-0.0	-0.1	-1.5	0.0	0.4	-1.0	1.2
Smoking Status	0.2	0.5	1.1	-0.4	-0.4	1.0	-0.5	-0.0	0.9	-0.8
Allergy or Eczema	0.6	1.5	3.8	-1.0	0.3	-1.3	-0.8	-1.9	0.2	-2.0
Cardiovascular Disease	0.2	0.5	1.3	-0.2	0.1	-1.1	-0.0	-0.3	-1.1	1.0
Hypothyroidism (self reported)	1.1	2.5	6.6	1.0	1.1	-1.2	1.4	-2.6	-0.9	-2.1
Respiratory disease	0.1	0.2	0.5	-0.6	-0.2	0.2	-0.3	0.4	0.7	0.4
Type 2 Diabetes (T2D) (2018)	0.8	1.5	6.5	0.3	1.2	-1.1	0.7	-2.5	-0.0	-1.1
Lung FEV1/FVC ratio	0.9	4.6	16.6	2.6	0.7	0.4	2.3	1.6	0.3	4.1
Lung FVC	0.9	4.8	13.8	-1.0	-1.3	3.0	-1.6	3.7	1.8	1.5
Neuroticism	2.6	6.2	10.0	-3.0	-2.2	0.2	-2.5	-3.2	-2.6	-2.5
Chronotype (morning person)	1.4	3.2	7.2	-1.8	-1.0	-0.9	-1.4	-2.7	-2.7	-0.9
Hair Pigment	0.1	1.5	4.3	-1.5	-1.2	2.1	-1.2	0.4	0.4	-0.7
Tanning	0.1	1.3	2.7	1.3	1.6	-0.4	1.5	0.1	1.3	0.5
Hand grip strength (left)	0.2	0.6	1.0	-1.0	-0.8	0.9	-0.9	-0.9	-0.2	-0.5
Number of treatments/medications taken	2.9	5.3	12.1	-2.4	-1.9	-0.4	-2.1	-3.5	-2.3	-2.4
Average weekly spirits intake	0.2	0.2	0.5	-0.7	-0.6	0.0	-0.6	0.1	-0.6	0.2
Sensitivity / hurt feelings	2.4	4.2	6.2	-2.5	-2.5	1.6	-2.2	-2.5	-1.9	-0.2
Frequency of depressed mood in last 2 weeks	6.4	9.0	16.6	-3.8	-4.1	2.3	-3.9	-0.2	-3.4	0.1
Hearing difficulty/problems: Yes	2.0	3.1	11.7	0.8	0.1	0.3	0.3	3.4	1.7	2.5
Relative age of first facial hair	0.0	0.1	0.2	0.3	0.4	0.1	0.3	-0.3	0.0	0.1
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.3	-1.7	-1.9	2.1	-2.0	0.9	0.1	0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	-0.5	-0.7	-0.2	-0.5	-0.3	-0.9	0.7
Ever had hysterectomy (womb removed)	0.1	0.2	0.4	-0.4	-0.7	-0.2	-0.3	-0.3	-0.3	-0.4
Systolic blood pressure, automated reading	0.1	0.4	1.3	-0.1	0.0	-0.8	0.2	-0.3	-1.1	0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.8	0.1	0.7	-1.1	0.2	-1.4	0.5	-0.3
Angina	2.1	2.8	7.9	-1.5	-1.1	-1.0	-1.3	-2.1	-2.8	1.0
Medication for hormone replacement therapy	1.4	1.6	2.8	-1.5	-1.4	0.6	-1.3	-1.7	-1.4	-0.5
Vitamin and mineral supplements	1.6	2.1	4.0	1.6	1.9	-2.0	1.6	-0.3	1.1	0.9
Supplements: Zinc	1.8	2.0	4.3	-1.1	-1.6	1.9	-1.4	2.1	-0.3	-0.4
Medication: Co-codamol	1.1	1.2	2.4	-1.5	-1.5	0.4	-1.2	-1.1	-1.0	-0.0
Medication: Metformin	0.6	0.9	3.6	0.2	1.1	0.0	0.6	-1.9	-0.8	-0.7
Diabetes (father)	1.5	1.9	6.7	1.2	0.7	-0.9	0.9	1.7	0.6	2.6
Diabetes (mother)	1.4	1.8	6.3	1.0	1.3	-0.1	1.1	-1.5	0.4	-2.5
Severe depression (siblings)	0.7	0.8	2.1	-0.7	-1.3	-1.5	-0.7	0.3	-0.7	0.8
Pack years adult smoking proportion	2.2	3.4	6.1	-2.4	-2.5	1.9	-2.5	-0.1	-1.6	0.2
Impedance of leg (right)	0.6	3.1	9.2	-1.6	-1.9	1.5	-1.7	-0.9	-0.6	-3.0
Leg fat-free mass (left)	0.2	1.3	2.4	-0.9	0.3	-1.1	-0.4	-1.5	-1.5	1.5
Trunk fat percentage	2.2	8.8	34.9	2.2	2.5	-5.9	2.9	-2.3	-0.8	1.3
Hand grip strength (right)	0.6	1.7	3.5	-1.6	-0.8	0.7	-1.2	-1.8	-0.4	-1.9
Townsend deprivation index at recruitment	1.1	1.5	2.9	-1.6	-1.6	1.2	-1.7	0.3	-1.0	0.5
Current tobacco smoking	0.2	0.3	1.0	-0.2	-0.2	0.8	-0.3	-1.0	-0.3	0.0
Average weekly fortified wine intake	0.7	0.8	4.6	-0.1	-0.4	2.1	-0.2	0.8	0.5	0.4
Maternal smoking around birth	1.9	2.8	5.7	2.2	2.3	-1.2	2.4	0.7	1.3	0.5
Fed-up feelings	1.2	2.1	9.4	-0.8	-0.5	-0.0	-0.5	-3.1	-2.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.0	4.1	7.3	-2.6	-2.6	1.9	-2.7	-0.2	-1.9	-0.3
Relative age voice broke	0.3	0.5	1.1	0.1	0.1	-1.1	0.1	-1.0	-1.0	-0.2
Taking other prescription medications	3.2	5.0	8.2	-2.5	-2.1	1.0	-2.2	-2.9	-2.3	-2.1
Age when periods started (menarche)	1.8	4.3	6.2	2.5	1.9	-0.9	2.4	2.2	2.2	2.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.7	1.0	0.4	-1.1	0.8	0.6	0.5	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.9	-1.1	-0.9	-0.3	-1.0	-0.6	0.0	-1.4
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.2	-0.0	-0.6	2.0	-0.3	1.6	0.3	2.0
Qualifications: CSEs or equivalent	1.8	2.4	3.9	-2.0	-2.0	0.4	-1.7	-1.7	-1.7	-0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.2	0.6	0.9	-1.1	0.6	-1.0	-0.5	-0.1
High blood pressure	0.5	1.3	2.9	-0.8	-0.4	-1.7	-0.5	-1.3	-1.6	0.8
Hayfever, allergic rhinitis or eczema	0.7	1.4	4.0	-1.3	0.1	-0.6	-0.9	-1.8	-0.2	-2.0
Multivitamins +/- minerals	2.4	3.0	5.9	-1.8	-2.4	2.2	-2.0	1.1	-1.4	-0.5
Stomach or abdominal pain in last month	0.9	1.2	3.2	-1.2	-1.8	0.5	-1.3	-0.3	-1.2	0.0
Supplements: Glucosamine	1.4	1.8	3.2	-1.6	-1.8	1.7	-1.7	-0.5	-0.3	-0.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.5	0.1	0.3	0.3	0.5	0.0	0.1
Medication: Atenolol	0.6	0.8	1.5	0.7	1.2	-1.1	0.8	-1.0	0.7	-0.5
Medication: Levothyroxine sodium	1.7	2.9	7.0	1.4	1.7	-1.6	1.7	-1.9	0.1	-2.6
Sitting height	1.0	6.8	13.3	-3.6	-2.7	1.2	-3.1	-2.6	-1.2	-2.9
Chronic bronchitis/emphysema (father)	0.2	0.3	1.4	0.1	0.4	-0.4	0.3	-0.2	-0.3	1.2
High blood pressure (mother)	0.4	0.5	0.8	-0.9	-0.7	0.6	-0.9	-0.4	-0.7	-0.8
Body mass index (BMI)	1.1	4.6	13.9	0.0	0.7	-3.7	0.8	-3.1	-2.4	1.5
Impedance of leg (left)	0.6	2.9	12.1	-1.2	-1.6	1.4	-1.3	-0.6	-0.1	-3.5
Leg predicted mass (left)	0.2	1.3	2.3	-0.9	0.4	-1.1	-0.3	-1.5	-1.5	1.4
Trunk fat mass	1.4	6.0	25.0	1.1	1.7	-5.0	1.9	-2.7	-1.3	1.0
Waist circumference	0.9	3.4	9.8	1.0	2.0	-3.1	1.6	-2.4	-0.6	0.1
Number of incorrect matches in round	1.4	2.3	9.5	0.7	0.8	-1.4	1.0	-1.3	0.8	-3.1
Past tobacco smoking	0.7	1.4	5.3	-1.2	-0.8	-0.2	-1.1	-0.8	-2.3	0.3
Alcohol usually taken with meals	2.2	3.5	6.0	1.8	1.7	-1.6	1.9	-0.8	2.4	-2.4
Nervous feelings	2.6	4.9	8.0	-2.5	-2.3	1.7	-2.6	-1.3	-1.8	-2.8
Frequency of tenseness / restlessness in last 2 weeks	7.8	12.1	22.8	-4.7	-4.6	2.7	-4.8	-1.5	-2.9	-1.0
Hearing difficulty/problems with background noise	2.0	3.3	6.6	-1.2	-2.1	1.9	-1.8	2.6	1.7	0.9
Hair/balding pattern: Pattern 2	1.1	1.4	4.2	0.6	1.4	-0.1	1.2	-2.1	-0.2	-1.3
Had menopause	0.2	0.3	0.7	-0.5	-0.4	0.5	-0.6	-0.8	-0.2	-0.5
Had other major operations	0.2	0.2	0.5	0.3	-0.5	0.4	0.1	0.7	-0.0	0.6
Forced vital capacity (FVC)	0.3	1.1	4.6	-1.1	-0.1	2.2	-1.0	0.4	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	4.7	-0.7	-0.6	-0.8	-0.5	-1.0	0.3	-2.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.2	-1.4	-1.6	0.4	-1.5	-0.5	-0.8	-1.8
Qualifications: None of the above	0.4	1.0	2.0	-0.6	-0.0	-1.0	-0.1	-1.4	-1.4	1.2
Financial difficulties in last 2 years	2.9	4.0	7.9	-2.8	-2.7	0.8	-2.8	-0.9	-1.5	-1.1
Mouth/teeth dental problems	0.5	0.8	3.1	-0.4	-0.4	1.1	-0.6	-0.5	-0.3	-1.8
Heart attack	1.1	1.4	4.9	-0.2	0.4	-2.0	0.2	-2.2	-0.5	-0.4
Allergy	0.5	1.1	3.0	1.3	-0.1	0.4	0.9	1.5	-0.1	1.7
Pain all over the body in last month	0.6	0.7	2.0	0.7	0.7	-0.8	0.8	-0.8	-0.1	-1.4
Diabetes (self-reported)	1.1	1.7	4.5	0.7	1.7	-0.9	1.0	-2.1	0.0	-1.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	7.7	-0.5	0.2	0.0	-0.1	-1.9	0.4	-2.8
Medication: Ramipril	0.6	0.8	2.1	0.8	0.6	-1.4	0.6	-0.6	0.1	-1.4
Medication: Simvastatin	0.4	0.5	2.8	0.3	-0.2	1.7	0.1	0.1	-0.4	0.7
Fluid intelligence score	0.3	0.5	2.0	0.1	-0.3	1.4	-0.2	0.9	-0.8	0.4
Illnesses of siblings	0.3	0.4	0.9	0.4	0.8	0.0	0.5	0.6	0.7	-1.0
Neuroticism score	2.2	4.6	8.0	-2.8	-2.3	0.9	-2.5	-2.3	-2.4	-1.1
Weight	0.7	3.4	9.2	-0.9	0.2	-2.9	-0.1	-3.0	-2.3	0.7
Impedance of arm (right)	1.2	5.8	9.5	3.1	2.6	-1.3	2.7	2.4	3.1	0.4
Arm fat percentage (right)	2.0	7.9	29.8	1.8	2.4	-5.5	2.6	-2.5	-0.9	1.5
Trunk fat-free mass	0.8	4.8	9.6	-3.1	-1.9	1.2	-2.7	-2.3	-2.4	-0.7
Hip circumference	0.7	3.2	9.5	0.6	1.6	-3.1	1.3	-2.1	-0.9	1.8
Time employed in main current job	0.5	0.6	1.0	0.9	1.0	0.4	0.6	0.6	0.8	0.7
Alcohol intake versus 10 years previously	2.8	4.1	12.1	2.7	3.5	-0.6	2.5	0.2	1.7	-0.3
Father’s age at death	0.7	0.9	3.0	0.3	0.1	1.7	0.1	1.0	1.3	0.8
Worrier / anxious feelings	2.8	5.4	14.3	-2.0	-1.3	2.4	-1.9	-2.5	-1.2	-3.8
Frequency of tiredness / lethargy in last 2 weeks	5.5	9.0	17.1	-4.0	-4.1	1.9	-4.1	-1.1	-2.7	-1.0
Falls in the last year	1.6	2.2	4.5	-2.1	-1.6	0.1	-2.0	-1.3	-0.9	-1.4
Hair/balding pattern: Pattern 3	0.3	0.4	1.9	-0.1	-0.8	-0.1	-0.7	1.4	-0.2	-0.1
Number of live births	1.1	1.6	5.9	-1.5	-0.2	-0.6	-1.0	-2.4	-1.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	2.3	-0.6	-0.1	1.5	-0.5	0.4	-0.1	0.8
Pulse rate	0.7	1.2	3.4	-0.1	-0.3	-0.1	-0.7	1.9	-1.0	1.8
Happiness	0.0	0.0	0.1	0.2	-0.3	0.1	0.0	0.0	-0.0	-0.2
Noisy workplace	0.8	1.0	2.6	1.6	1.0	-1.1	1.3	0.2	-0.5	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	0.5	1.1	1.2	0.3	0.7	0.3	0.0
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	7.2	2.0	2.7	-0.1	2.3	0.2	2.3	-0.8
Mouth/teeth dental problems: Dentures	0.7	1.1	3.6	0.2	0.1	-1.9	0.5	-1.4	-1.2	-0.7
Asthma	0.2	0.3	1.2	-0.3	0.1	-0.5	-0.1	0.4	1.1	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.2	1.3	1.3	0.3	1.8	-0.8	0.6	-1.1
Medication: Cholesterol lowering	0.8	1.2	3.3	-1.0	-1.1	0.7	-1.0	-1.1	-1.8	-0.6
Depression (self-reported)	4.1	4.9	8.1	-2.8	-2.8	0.2	-2.8	-1.9	-2.6	-0.5
Medication: Lansoprazole	0.6	0.7	2.3	0.7	0.9	0.2	0.7	-1.5	0.8	-0.2
Prospective memory result	0.2	0.3	0.7	-0.7	0.0	-0.8	-0.6	-0.2	0.2	-0.7
Lung cancer (father)	0.9	1.0	1.7	1.0	1.3	-0.7	1.1	0.5	1.1	-1.1
Illnesses of mother	0.3	0.4	1.6	-0.3	-0.5	0.7	-0.4	0.6	0.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.5	-0.4	-0.7	2.1	-0.5	1.4	-0.0	1.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	0.8	1.1	0.5	0.8	-0.4	-0.0	0.1
Impedance of arm (left)	2.0	9.3	15.9	4.0	3.5	-1.6	3.6	2.8	3.5	1.1
Arm fat mass (right)	1.5	6.0	20.7	0.7	1.5	-4.5	1.5	-3.4	-1.9	1.1
Trunk predicted mass	0.8	4.8	9.7	-3.1	-2.0	1.3	-2.7	-2.3	-2.3	-0.7
Standing height	0.2	2.0	3.8	-1.9	-1.1	1.2	-1.8	-0.6	-0.5	-1.8
Length of working week for main job	0.9	0.9	3.5	0.4	0.5	0.1	0.8	-1.4	0.3	-1.9
Exposure to tobacco smoke at home	0.6	0.7	1.9	0.9	1.0	-1.4	0.7	0.3	0.5	0.3
Breastfed as a baby	1.2	1.5	5.3	0.3	-0.2	2.3	-0.3	1.9	1.1	0.4
Tense / ‘highly strung’	3.6	6.0	11.6	-3.4	-3.0	0.6	-3.4	-1.0	-2.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	7.4	11.3	23.7	-4.9	-4.4	1.7	-4.5	-2.2	-2.3	-1.3
Hair/balding pattern: Pattern 4	0.4	1.0	3.0	0.2	0.1	1.2	-0.1	1.4	1.7	0.7
Birth weight of first child	0.9	1.6	4.8	-1.3	-1.4	2.2	-1.2	0.9	0.6	-0.4
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.4	0.7	0.3	0.7	0.4	-0.1	0.1
Pulse wave reflection index	1.0	1.2	4.1	0.4	0.5	0.2	0.6	-1.8	0.7	-2.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.1	0.1	-0.2	-1.5	0.1	-0.7	0.2	-0.7
Loud music exposure frequency	1.7	1.8	3.7	-1.9	-1.7	1.3	-1.9	0.0	-0.8	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.0	0.6	0.4	0.2	-0.9	-0.6	-0.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.3	1.1	0.8	-1.1	1.2	0.8	0.5	2.1
Blood clot in the leg (DVT)	0.9	1.1	1.9	-1.2	-1.4	1.0	-1.1	-0.3	-1.3	-0.7
Medication: Paracetamol	1.5	2.5	5.8	-1.4	-1.3	-0.0	-1.1	-1.4	-2.2	-2.4
Headache pain in last month	4.1	7.0	13.2	-3.6	-3.5	-0.1	-3.5	-1.5	-2.4	-1.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	4.0	1.1	0.7	0.4	0.9	1.7	2.0	0.3
Glaucoma (self-reported)	0.8	0.9	1.3	1.0	1.1	1.1	0.7	0.9	1.1	-0.7
Gout (self-reported)	0.9	1.2	2.2	-1.5	-1.3	0.6	-1.5	-0.2	-1.3	0.3
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	4.2	1.8	1.8	-1.7	2.0	-1.5	-0.4	-2.0
Medication: Amlodipine	0.9	1.2	3.6	-1.0	-0.7	1.9	-1.0	-1.3	-0.8	0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	-0.3	0.4	-0.6	-0.1	-0.3	-0.7	1.0
Birth weight	0.9	1.9	5.5	1.2	0.9	0.5	1.2	2.0	2.4	0.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.7	-0.9	-0.6	-2.4	-0.8	-0.5	-1.7	0.6
High blood pressure (siblings)	0.1	0.1	0.5	0.2	0.0	-0.1	0.3	-0.7	0.0	-0.2
Forced vital capacity (FVC), Best measure	0.5	1.8	7.4	-0.9	-0.7	2.7	-1.0	1.5	0.8	0.2
Body fat percentage	1.9	7.3	30.2	1.5	1.9	-5.5	2.3	-2.7	-1.2	0.9
Leg fat percentage (right)	1.4	5.1	15.1	-0.5	0.2	-3.7	0.2	-3.9	-2.5	-0.3
Arm fat-free mass (right)	1.2	5.9	10.4	-3.2	-2.1	0.2	-2.6	-3.1	-3.1	-0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.5	0.8	0.1	0.5	1.0	0.1	0.8
Comparative body size at age 10	0.7	2.0	3.6	-0.9	-1.9	-1.1	-1.2	1.0	-1.6	1.8
Number of full brothers	0.9	1.1	2.8	1.1	1.1	1.1	1.1	-0.1	0.4	1.7
Worry too long after embarrassment	3.5	5.8	11.8	-3.4	-3.0	2.0	-3.0	-2.0	-1.4	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	3.6	4.7	10.5	-2.9	-3.2	1.2	-2.9	-0.2	-1.7	-1.1
Wheeze or whistling in the chest in last year	0.2	0.4	1.9	-0.5	-0.1	0.5	-0.6	0.2	0.5	1.4
Number of children fathered	0.5	0.6	1.7	-0.0	0.1	0.8	0.2	-1.3	0.4	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	6.6	-0.3	-0.1	0.8	-0.1	-1.3	-0.3	-2.6
Age at first live birth	1.9	3.4	5.2	2.2	1.7	-0.2	2.0	1.7	2.1	-2.3
Pulse wave peak to peak time	0.5	0.6	1.4	-1.1	-1.2	-0.6	-1.1	0.0	-0.3	-0.5
Health satisfaction	0.7	0.9	1.5	-0.7	-1.0	-0.4	-1.0	-1.2	-0.9	-1.2
Shortness of breath walking on level ground	0.2	0.3	1.5	-0.1	-0.3	0.1	-0.3	-1.2	-0.5	-0.3
Qualifications: College or University degree	1.5	4.7	10.6	2.0	2.4	1.5	1.7	0.9	3.3	-2.5
Eye problems/disorders: None of the above	1.0	1.1	2.4	-1.1	-1.6	1.1	-1.1	0.3	-1.3	0.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	0.7	1.0	-0.5	0.7	-0.1	1.2	-0.1
Emphysema/chronic bronchitis	1.2	1.3	5.5	-0.2	0.3	0.9	0.1	-1.7	0.1	-2.3
Medication for pain relief, constipation, heartburn	2.0	3.5	10.2	1.2	1.0	0.8	0.7	3.2	2.7	1.9
Neck or shoulder pain in last month	0.4	0.5	1.1	-0.8	-0.4	1.1	-0.8	-0.6	-0.6	0.5
Medication: Blood pressure	1.1	2.0	3.5	-1.8	-1.0	-0.2	-1.4	-1.9	-1.6	-1.3
Angina (self-reported)	2.0	2.6	7.6	-1.4	-0.8	-1.1	-1.2	-2.3	-2.8	0.6
Migraine (self-reported)	0.3	0.4	2.4	0.1	-0.5	-1.6	-0.0	-0.1	-0.3	0.4
Medication: Ibuprofen	1.1	1.3	3.4	1.0	1.0	-0.2	1.5	-1.2	0.5	-1.8
Medication: Allopurinol	2.0	2.7	4.9	-2.0	-2.0	0.1	-2.1	-1.3	-2.2	-0.5
Medication: Omeprazole	1.1	1.4	2.8	-1.3	-1.4	-0.6	-1.4	-0.9	-1.7	0.4
Medication: Seretide 50 evohaler	2.8	3.2	15.0	0.1	0.8	1.2	0.6	-2.2	0.6	-3.9
Mean time to correctly identify matches	0.9	1.7	5.3	-0.4	-0.0	-1.9	-0.1	-2.3	-1.6	0.7
Heart disease (mother)	0.7	0.9	2.3	1.0	0.4	-0.7	1.0	0.7	1.5	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.2	1.5	1.8	-1.1	1.6	-0.2	1.0	0.4
Whole body fat mass	1.3	5.6	21.0	0.5	1.2	-4.6	1.4	-3.3	-1.8	0.5
Leg fat mass (right)	1.3	5.1	13.8	-0.9	0.1	-3.7	-0.0	-3.7	-2.7	0.2
Arm predicted mass (right)	1.0	5.1	9.1	-3.0	-1.8	0.1	-2.3	-3.0	-2.9	-0.7
Pulse rate, automated reading	0.2	0.7	3.1	-0.7	-0.6	-0.3	-0.8	-0.6	-1.8	0.2
Alcohol intake frequency.	0.4	1.0	2.3	0.4	0.3	-1.5	0.4	-1.4	-0.9	1.3
Comparative height size at age 10	0.2	1.1	2.0	-1.1	-1.0	1.4	-1.4	0.2	-0.8	-1.0
Number of full sisters	0.5	0.6	1.2	-1.0	-1.1	0.5	-1.0	0.5	-0.5	0.2
Suffer from ‘nerves’	1.5	2.3	5.0	-2.2	-2.2	0.8	-2.1	-0.4	-0.9	-0.4
Overall health rating	0.5	1.1	1.9	-1.3	-1.0	0.9	-1.4	-0.6	-1.3	0.4
Chest pain or discomfort	1.5	2.2	11.6	-0.7	-0.8	0.3	-0.7	1.1	-0.9	3.4
Had major operations	0.5	0.6	1.8	-0.6	-0.5	0.5	-0.8	1.4	0.2	0.7
Age at last live birth	2.1	3.0	4.7	2.1	1.8	-1.3	2.1	1.0	2.2	-1.3
Family relationship satisfaction	0.4	0.5	1.2	0.2	-0.5	0.9	-0.1	1.0	0.1	1.1
Leg pain on walking	0.5	0.6	2.1	-0.9	-0.1	1.0	-0.6	-1.4	-0.4	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.7	-0.5	-1.1	-1.1	-0.6	-0.7	-1.6	0.4
Commuting to job workplace: Car/motor vehicle	1.6	1.8	8.8	-1.2	-0.5	0.3	-0.5	-3.0	-0.9	-1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.8	0.4	-0.2	-0.1	0.2	0.4	-1.4	1.1
Medication: Aspirin	0.8	1.1	3.3	-0.6	-0.1	-1.3	-0.4	-1.8	-1.4	-0.5
Supplements: Vitamin C	1.1	1.3	2.4	-1.4	-1.6	1.1	-1.2	-0.0	-1.5	-0.1
Knee pain experienced in last month	1.5	2.4	10.5	-1.4	-0.4	0.3	-0.9	-3.2	-1.4	-1.1
Hypertension (Self-reported)	0.4	1.2	3.1	-0.5	0.2	-1.8	-0.2	-1.6	-1.4	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.3	0.1	0.0	0.2	-0.0	0.2	0.0
Illnesses of father: Heart disease	0.7	1.0	4.3	0.3	0.4	-0.3	0.4	0.2	-1.4	2.1
Illnesses of siblings: Diabetes	0.8	1.0	2.8	0.2	0.1	-1.7	0.2	-0.9	-1.2	1.3
Smoking status: Previous	0.6	0.9	3.4	0.8	0.5	0.3	0.8	0.6	1.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.5	-1.4	-1.3	-0.5	-1.5	0.5	-1.6	0.9
Whole body fat-free mass	0.5	2.8	5.4	-2.3	-1.1	0.2	-1.8	-2.1	-2.2	0.1
Leg fat-free mass (right)	0.2	0.9	1.9	-0.5	0.6	-1.1	-0.0	-1.0	-1.1	1.4
Arm fat percentage (left)	2.2	8.9	31.5	2.2	2.8	-5.6	3.0	-2.2	-0.8	2.0
Average weekly red wine intake	1.2	1.8	6.0	0.4	-0.7	1.1	0.2	2.1	2.5	-0.1
Handedness (chirality/laterality): Left-handed	1.2	1.5	6.7	-0.7	-0.7	2.6	-0.8	1.0	0.9	0.4
Mood swings	4.0	7.2	15.2	-2.7	-2.4	-0.9	-2.3	-3.9	-3.5	-2.1
Loneliness, isolation	0.1	0.1	0.2	-0.4	-0.1	-0.0	-0.1	-0.4	0.0	0.3
Long-standing illness, disability or infirmity	2.2	3.4	6.1	-2.5	-1.9	1.9	-2.4	-1.7	-1.5	0.1
Ever had bowel cancer screening	0.4	0.5	1.1	0.4	-0.5	0.8	0.0	1.1	-0.3	-1.1
Diabetes diagnosed by doctor	0.8	1.3	5.3	0.2	1.2	-0.6	0.6	-2.3	-0.2	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.6	0.2	0.4	0.2	0.4	-0.7	1.3	-1.1
Friendships satisfaction	0.6	0.7	1.4	1.2	0.9	0.6	1.1	0.7	-0.2	0.9
Qualifications: nursing, teaching	1.8	2.8	5.6	-2.4	-1.3	1.2	-2.1	-1.8	-1.0	-1.6
Commuting to job workplace: Walk	0.5	0.5	2.3	-0.2	0.3	0.3	-0.4	0.7	0.6	-1.5
Eye problems/disorders: Cataract	1.6	1.9	3.3	1.5	1.8	-1.8	1.5	-0.3	0.6	1.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	3.3	-0.9	-0.7	0.1	-1.0	1.8	0.6	1.1
Medication for cholesterol	0.2	0.3	0.9	0.5	0.2	0.4	0.5	0.9	0.4	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.0	5.9	10.8	-3.3	-2.7	-0.9	-3.1	-2.1	-1.8	-2.2
Back pain experienced in last month	4.0	5.8	10.6	-3.2	-3.2	1.9	-3.2	-0.9	-2.1	-1.1
Mineral and other dietary supplements	2.9	3.9	8.0	2.6	2.8	-0.9	2.5	0.8	1.8	1.2
Breast cancer (self-reported)	0.3	0.4	1.2	-0.6	-0.5	0.2	-0.7	0.1	-0.7	-1.1
Asthma (self-reported)	0.2	0.3	1.2	-0.5	0.1	-0.5	-0.2	0.2	1.1	0.6
Osteoporosis (self-reported)	0.3	0.4	0.6	0.7	0.2	-0.4	0.7	0.8	0.7	0.7
Osteoarthritis (self-reported)	2.4	3.2	12.2	-1.0	0.1	-0.8	-0.3	-3.5	-1.6	-2.4
Medication: Aspirin	1.3	1.6	5.5	-0.5	-0.0	-1.6	-0.3	-2.3	-1.6	-0.9
Medication: Gliclazide	1.0	1.1	3.0	1.3	1.7	-0.3	1.3	0.3	0.9	-0.4
Illnesses of father: None of the above (group 1)	1.4	1.8	4.8	0.8	0.7	-1.2	0.8	-0.7	2.0	-2.2
Smoking status: Current	0.2	0.3	1.1	-0.4	-0.3	0.3	-0.4	-1.1	-0.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.7	0.7	0.4	1.1	0.8	1.0	1.3	1.6
Whole body water mass	0.5	3.1	6.1	-2.5	-1.3	0.2	-1.9	-2.3	-2.3	0.0
Leg predicted mass (right)	0.2	0.8	2.0	-0.5	0.6	-1.0	-0.1	-1.0	-1.1	1.4
Arm fat mass (left)	1.4	5.7	20.2	0.7	1.5	-4.5	1.6	-3.0	-1.7	1.4
Number of self-reported non-cancer illnesses	0.9	1.5	3.3	-1.5	-1.0	-0.1	-1.4	-1.8	-1.3	-0.7
Average weekly champagne plus white wine intake	1.8	2.5	6.5	1.1	2.1	-0.3	1.2	0.5	2.6	-1.9
Miserableness	2.6	4.5	7.6	-2.5	-1.7	-0.2	-2.3	-2.8	-2.2	-2.2
Guilty feelings	2.1	3.2	7.0	-2.6	-1.6	1.8	-2.4	-1.3	-0.9	-1.2
Wears glasses or contact lenses	1.4	1.7	5.0	1.6	2.2	-0.6	1.7	0.4	0.7	0.1
Ever taken oral contraceptive pill	0.5	0.6	2.0	-0.3	-1.0	-0.7	-0.3	-0.8	-1.4	0.0
Hearing aid user	0.1	0.1	0.3	-0.2	-0.2	0.5	-0.2	0.3	-0.2	0.6
Mother’s age at death	0.6	0.7	2.1	0.3	0.6	0.6	0.2	-0.5	1.3	-1.5
Financial situation satisfaction	2.5	3.1	6.8	-1.4	-2.6	2.4	-2.0	0.6	-1.7	0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	4.9	-0.4	0.2	-0.4	-0.1	-2.2	0.0	-0.3
Commuting to job workplace: Public transport	0.3	0.4	1.6	0.5	0.1	0.3	0.1	1.3	-0.8	0.5
Eye problems/disorders: Glaucoma	0.5	0.6	2.6	-0.4	-0.1	1.6	-0.4	0.2	0.7	-0.9
Medication: Blood pressure	0.4	0.8	4.0	-0.2	0.0	-2.0	-0.1	-1.1	-0.3	0.6
Pain type(s) experienced in last month: Hip pain	2.2	2.8	5.7	-2.3	-2.4	1.5	-2.0	-0.7	-1.4	0.3
Supplements: Fish oil (including cod liver oil)	4.1	5.4	13.0	-2.9	-3.6	0.9	-3.0	-0.8	-2.4	-0.6
High cholesterol (Self-reported)	0.2	0.4	1.8	0.1	0.1	1.3	-0.0	0.9	0.4	0.5
Medication: Bendroflumethiazide	0.1	0.2	1.3	-0.1	0.0	-0.4	-0.0	-1.1	-0.1	-0.3
Medication: Paracetamol	1.5	2.4	6.1	-1.5	-1.2	-0.4	-1.1	-1.6	-1.8	-2.5
Medication: Lisinopril	0.4	0.5	1.9	0.5	0.6	-0.8	0.5	0.4	0.0	1.4
Medication: Atorvastatin	0.3	0.4	1.9	-0.5	0.1	0.5	-0.4	-0.3	-0.2	-1.4
Illnesses of father: High blood pressure	0.3	0.4	1.0	-0.6	-0.4	0.8	-0.5	-0.5	-0.4	1.0
Alcohol drinker status: Never	1.8	2.2	6.6	-1.5	-1.2	-0.8	-1.1	-2.6	-1.5	1.0
Ever smoked	0.5	0.9	3.2	0.6	-0.1	1.4	0.4	0.6	1.8	-0.5
Basal metabolic rate	0.4	2.5	5.8	-2.0	-0.7	-0.5	-1.4	-2.4	-2.2	0.3
Leg fat percentage (left)	1.3	4.7	15.1	-0.1	0.4	-3.9	0.6	-3.5	-2.2	-0.4
Arm fat-free mass (left)	1.2	6.2	11.4	-3.3	-2.2	0.3	-2.6	-3.4	-2.9	-1.0
Number of operations (self-reported)	0.6	0.8	1.5	-0.9	-1.2	0.7	-1.1	0.2	-1.0	0.8
Average weekly beer plus cider intake	0.3	0.5	1.5	0.4	0.3	1.2	0.5	0.3	-0.1	1.0
Irritability	0.0	0.1	0.2	-0.2	-0.4	-0.4	-0.0	-0.2	-0.0	0.2
Risk taking	0.3	0.5	0.9	0.8	0.9	0.5	0.9	0.7	0.4	0.5
Ever had prostate specific antigen (PSA) test	1.3	1.5	7.5	0.6	0.7	-2.7	0.5	-0.1	-0.1	-1.4
Fractured/broken bones in last 5 years	0.5	0.6	1.2	0.8	1.1	-0.1	0.8	1.0	0.7	0.8
Age started oral contraceptive pill	1.1	1.4	5.8	1.0	0.8	0.7	0.9	0.4	0.7	-2.4
Diastolic blood pressure, automated reading	0.5	1.5	4.0	-0.8	-1.2	0.1	-0.8	0.7	-1.7	2.0
Ever depressed for a whole week	0.8	1.0	3.2	-1.1	-1.2	0.2	-1.0	-0.4	-0.4	-1.8
Unable to work because of sickness or disability	0.8	1.0	2.6	-1.1	-1.1	-0.8	-1.1	-0.2	-1.6	0.5
Commuting to job workplace: Cycle	6.2	7.4	11.8	3.4	3.0	-1.7	3.2	2.6	3.2	1.4
Myopia	4.8	7.0	12.0	3.2	2.1	1.8	2.5	3.4	3.5	1.1
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.7	1.2	0.7	1.9	0.8	1.9	2.2	-0.7
Cholesterol lowering medication	0.4	0.6	1.1	0.6	0.9	0.9	0.4	0.1	1.0	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.4	1.6	2.9	-1.3	-1.5	-0.8	-1.4	-1.4	-1.7	0.3
Pain experienced in last month	1.0	1.7	3.1	1.3	1.1	-1.1	1.1	1.8	1.2	1.5
Supplements: Calcium	0.3	0.4	2.0	0.0	0.2	0.6	0.3	-0.2	1.4	-0.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.2	-0.1	-0.2	-0.0	0.8	0.2	0.9
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.9	0.0	0.6	-2.2	0.4	-2.0	-0.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	1.9	-1.0	-1.1	1.4	-0.9	-0.5	-1.3	-0.8
Heart disease (siblings)	0.8	1.0	2.5	-0.6	-0.9	0.4	-0.8	-0.5	-1.5	1.6
Alcohol drinker status: Previous	0.8	0.9	1.9	1.2	1.3	-0.4	1.4	-0.5	0.8	-0.1
Pack years of smoking	1.5	2.2	4.2	-1.7	-2.0	1.7	-1.9	0.5	-1.2	0.3
Impedance of whole body	0.4	1.9	3.8	1.7	1.1	-0.7	1.4	1.4	1.9	-1.0
Leg fat mass (left)	1.2	4.6	12.5	-0.7	0.2	-3.5	0.2	-3.5	-2.5	0.1
Arm predicted mass (left)	1.1	5.6	10.2	-3.2	-2.0	0.2	-2.6	-3.0	-3.0	-0.6