Hub : Genes

ZNF114

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0677 0.0281 5.2e-05 0.018 0.021 0.031 NA 0.028 0.00009 2.8e-05 4.6e-07 NA 1.6e-06
2 TCGA Head and Neck Squamous Cell Carcinoma 0.0523 0.0211 1.7e-06 0.032 0.053 0.050 NA 0.046 0.00014 1.2e-06 2.5e-06 NA 6.4e-06
3 TCGA Lung Adenocarcinoma 0.0496 0.0302 8.8e-03 0.005 0.014 0.013 NA 0.007 0.08300 7.6e-03 1.1e-02 NA 4.5e-02
4 TCGA Testicular Germ Cell Tumors 0.1940 0.1170 6.2e-03 0.067 0.077 0.055 NA 0.063 0.00220 1.1e-03 5.2e-03 NA 3.0e-03
5 TCGA Uterine Corpus Endometrial Carcinoma 0.3040 0.1260 8.3e-03 -0.010 0.026 0.014 NA -0.010 0.76000 6.3e-02 1.3e-01 NA 8.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.8 1.3 2.6 -1.0 -1.3 -1.6 0.0 -1.2
Bipolar Disorder or Schizophrenia 0.5 1.2 2.1 -0.7 -1.4 -1.4 1.2 -0.4
Depressed Affect (Nagel 2018) 1.0 2.2 4.2 -1.5 -1.3 -2.1 0.8 -1.4
Depression (Nagel 2018) 1.4 2.1 3.5 -1.6 -1.8 -1.9 0.9 -0.8
Intelligence (Savage-Jansen 2018) 0.7 2.2 5.2 -2.0 0.1 -1.0 -1.0 -2.3
Neuroticism (Nagel 2018) 1.0 2.4 4.9 -2.2 -0.8 -2.0 0.3 -1.4
Schizophrenia (2018) 0.3 0.7 2.3 -0.2 -0.9 -0.5 1.5 0.5
Schizophrenia vs Biploar Disorder 0.3 0.3 0.7 0.6 -0.7 0.4 0.9 0.1
Worry (Nagel 2018) 0.3 0.5 1.4 -1.2 0.0 -1.0 -0.2 -0.5
Alzheimer’s Disease (in mother) 0.4 0.4 0.8 -0.5 -0.9 -0.6 0.7 -0.6
Alzheimer’s Disease (in father) 0.5 0.6 1.6 0.2 0.2 -0.9 -0.7 -1.2
Alzheimer’s Disease (including proxy) 0.9 1.4 3.9 -0.5 -0.9 -1.4 -0.0 -2.0
Crohns Disease (2017) 0.5 1.2 2.1 -0.7 1.3 0.5 -1.5 -1.1
Irritable Bowel Disease (IBD) 0.6 1.4 4.7 -0.9 -0.1 -0.4 -1.2 -2.2
Ulcerative Colitis (UC) 1.0 1.9 5.6 -0.7 -1.4 -1.0 -0.6 -2.4
Major Depression (MDD) 0.1 0.1 0.2 0.1 0.0 0.3 -0.2 0.4
Reaction Time 0.3 0.5 1.0 -0.7 -0.2 0.2 -1.0 -0.9
Verbal and Numeric Reasoning (VNR) 0.9 2.1 3.7 -1.5 1.0 -0.2 -1.9 -1.8
Breast Cancer 0.8 1.9 3.9 1.1 1.6 2.0 -1.4 0.0
Ovarian Cancer 0.3 0.3 0.9 0.2 0.6 0.6 -1.0 0.0
Prostate Cancer 0.7 1.0 1.8 0.8 1.4 0.8 -1.4 0.3
Age at First Birth 1.1 1.6 3.3 -1.3 0.6 -0.3 -1.6 -1.8
Bipolar Disorder (2011) 0.4 0.4 0.7 -0.7 0.3 -0.5 -0.9 -0.7
Body Mass Index (BMI) (2010) 0.1 0.1 0.3 -0.1 -0.2 -0.3 0.3 -0.6
Coronary Artery Disease (CAD) 3.8 4.6 10.3 -2.0 -3.2 -1.9 1.4 -1.7
Crohns Disease (2012) 0.8 1.3 2.8 0.4 1.6 1.7 -0.8 0.6
Mean Putamen Volume 1.3 1.5 4.7 0.9 -0.1 0.5 1.3 2.2
Fasting Glucose 0.6 0.7 1.7 -1.3 -0.9 -0.9 0.2 0.4
HbA1C 0.4 0.5 1.4 0.7 1.2 0.3 -0.6 -0.1
HDL Cholesterol 1.3 2.1 4.0 1.9 1.4 2.0 -0.4 0.7
LDL Cholesterol 0.4 0.6 1.5 -0.2 0.3 0.5 -1.1 -1.2
Lupus 0.3 0.5 1.3 -0.5 -0.8 -1.1 0.7 -0.0
Neuroticism (2016) 0.6 0.9 2.7 1.0 0.7 -0.3 0.6 1.7
Primary Biliary Cirrhosis 0.8 1.2 2.0 -1.1 -1.2 -1.4 1.0 -0.5
Rheumatoid Arthritis 0.3 0.4 0.9 -1.0 -0.7 -0.4 0.3 0.4
Schizophrenia (2014) 0.6 1.4 2.9 -0.6 -1.7 -1.2 1.5 0.0
Triglycerides 0.9 1.5 4.5 -2.1 -0.7 -1.4 -0.2 -0.8
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.1 -0.0 -0.0 0.9 0.2 1.1
Ulcerative Colitis 2.0 2.8 5.8 -1.6 -2.4 -1.7 0.6 -1.6
Blood Eosinophil Count 0.1 1.2 3.4 1.8 0.6 0.2 1.2 0.7
Blood Platelet Count 1.6 19.0 28.2 5.0 5.1 5.3 -1.6 3.7
Blood Red Count 0.0 0.3 1.1 -1.1 0.3 -0.6 -0.2 -0.3
Blood White Count 1.4 10.3 17.0 3.4 4.1 3.8 -2.8 0.9
Heel T-Score 0.0 0.1 0.2 0.4 0.4 -0.3 0.0 0.3
BMI 0.1 0.5 1.5 -0.5 0.5 -0.1 -1.2 -0.5
Height 0.3 6.5 21.0 -4.6 -2.2 -2.2 -0.5 -1.3
Waist Hip Ratio (WHR) 0.1 0.7 2.2 0.4 1.5 0.5 -0.8 -0.1
Systolic Blood Pressure 0.6 2.8 5.8 2.4 1.9 1.1 -0.2 1.9
Smoking Status 0.2 0.5 1.0 -0.4 -0.7 -1.0 0.4 -1.0
Allergy or Eczema 0.9 2.4 6.0 -0.2 1.2 2.4 -2.1 0.2
Cardiovascular Disease 0.0 0.0 0.0 0.2 0.1 0.1 -0.0 -0.0
Hypothyroidism (self reported) 0.4 0.8 1.5 1.2 1.1 -0.2 -1.1 0.1
Respiratory disease 0.6 1.3 2.8 1.7 0.8 1.4 0.2 1.1
Type 2 Diabetes (T2D) (2018) 0.4 0.7 3.1 -1.8 -0.3 -0.2 -0.4 0.2
Lung FEV1/FVC ratio 0.1 0.7 1.8 0.0 1.3 -0.0 -1.2 -0.3
Lung FVC 0.0 0.2 0.5 -0.6 -0.4 -0.2 0.0 -0.7
Neuroticism 0.4 0.9 1.7 -0.7 -1.1 -1.3 1.1 -0.3
Chronotype (morning person) 0.1 0.3 0.8 0.4 0.2 0.5 -0.9 0.2
Hair Pigment 0.1 1.7 3.0 1.7 -0.5 0.2 1.5 1.7
Tanning 0.1 1.2 3.5 0.8 -1.1 -0.6 1.9 0.6
Hand grip strength (left) 0.6 1.6 4.0 0.8 2.0 0.4 -1.5 0.8
Number of treatments/medications taken 0.1 0.1 0.5 -0.7 -0.4 -0.1 0.2 0.0
Average weekly spirits intake 0.8 1.0 2.5 -0.4 -1.4 -0.6 0.1 -1.6
Sensitivity / hurt feelings 0.9 1.5 2.3 -0.3 -1.5 -1.4 1.2 -1.4
Frequency of depressed mood in last 2 weeks 1.4 1.9 3.2 -1.2 -1.8 -1.8 1.1 -0.8
Hearing difficulty/problems: Yes 0.2 0.3 0.8 0.1 0.7 -0.3 0.3 0.9
Relative age of first facial hair 0.2 0.3 0.8 -0.4 -0.6 -0.5 0.9 0.4
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 2.0 -0.2 -1.4 -0.4 1.0 -0.7
Ever used hormone-replacement therapy (HRT) 1.2 1.5 2.3 -1.3 -1.5 -1.2 0.1 -1.5
Ever had hysterectomy (womb removed) 0.3 0.4 0.8 -0.3 -0.9 -0.6 0.9 0.1
Systolic blood pressure, automated reading 0.5 1.3 2.2 1.4 1.1 1.1 -0.3 1.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.4 -1.5 -0.4 -0.8 0.3 -0.0
Angina 1.7 2.3 5.7 2.0 0.9 2.4 -0.5 0.8
Medication for hormone replacement therapy 0.0 0.0 0.0 0.1 0.1 -0.0 0.1 0.2
Vitamin and mineral supplements 0.1 0.2 0.4 -0.7 -0.0 -0.6 -0.1 -0.1
Supplements: Zinc 0.3 0.3 0.7 0.3 -0.8 -0.6 0.3 -0.7
Medication: Co-codamol 0.2 0.3 0.7 -0.9 -0.5 -0.6 0.2 0.3
Medication: Metformin 1.0 1.4 2.9 1.1 1.7 1.4 -0.7 0.5
Diabetes (father) 0.0 0.0 0.1 0.2 0.4 0.2 -0.0 0.1
Diabetes (mother) 0.8 1.0 2.4 1.2 1.6 0.7 -0.6 0.5
Severe depression (siblings) 0.1 0.1 0.2 -0.1 -0.5 -0.4 -0.1 -0.4
Pack years adult smoking proportion 0.1 0.2 0.4 0.6 0.6 -0.2 0.1 -0.3
Impedance of leg (right) 0.2 0.9 2.1 -0.2 -1.4 -0.8 1.4 0.1
Leg fat-free mass (left) 0.3 1.7 4.9 -2.2 -0.3 -1.4 -0.9 -0.8
Trunk fat percentage 0.1 0.2 0.6 -0.5 0.2 -0.0 -0.8 -0.3
Hand grip strength (right) 1.8 4.8 11.2 0.8 3.4 1.8 -2.5 1.6
Townsend deprivation index at recruitment 1.0 1.5 4.5 -0.1 -2.1 -0.3 1.2 -1.1
Current tobacco smoking 0.6 1.0 3.9 2.0 0.0 -0.7 0.7 -0.4
Average weekly fortified wine intake 0.8 0.9 3.2 0.1 1.8 0.5 -1.0 0.3
Maternal smoking around birth 1.9 2.7 5.9 2.4 1.2 1.3 1.0 1.9
Fed-up feelings 0.7 1.3 2.6 0.3 -1.4 -1.2 1.6 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 7.1 -1.3 -2.7 -2.3 1.6 -1.2
Relative age voice broke 0.3 0.5 1.0 0.2 -0.9 -0.1 1.0 0.9
Taking other prescription medications 0.2 0.3 0.8 0.0 -0.9 -0.3 0.8 0.2
Age when periods started (menarche) 0.1 0.3 0.5 -0.5 -0.5 0.3 -0.7 -0.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.2 0.8 0.2 1.1 -0.2 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.8 -0.1 0.3 -0.9 -0.7 -0.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.7 -0.8 0.4 0.3 0.8 0.6
Qualifications: CSEs or equivalent 0.3 0.4 1.8 1.3 0.0 -0.0 0.4 0.4
Serious illness, injury or assault to yourself 0.2 0.2 0.4 -0.6 -0.4 -0.3 0.7 -0.1
High blood pressure 0.1 0.2 0.4 0.6 0.2 0.4 0.0 0.4
Hayfever, allergic rhinitis or eczema 0.8 1.7 4.9 0.3 1.1 2.2 -1.4 0.7
Multivitamins +/- minerals 1.8 2.3 3.8 1.6 1.8 2.0 -1.1 0.7
Stomach or abdominal pain in last month 0.4 0.5 1.2 0.1 1.1 0.5 -0.9 -0.5
Supplements: Glucosamine 1.3 1.7 2.9 0.4 1.7 1.6 -1.7 -0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.5 0.7 0.3 1.2 -0.3 -0.2
Medication: Atenolol 0.1 0.2 0.6 -0.1 -0.4 -0.2 0.8 0.0
Medication: Levothyroxine sodium 0.4 0.7 1.5 0.5 1.2 -0.3 -1.2 -0.2
Sitting height 0.7 4.6 16.4 -4.0 -1.1 -2.2 -0.6 -0.8
Chronic bronchitis/emphysema (father) 0.4 0.5 1.2 0.7 0.3 1.1 0.5 0.6
High blood pressure (mother) 1.4 2.0 3.5 -0.6 -1.9 -1.7 1.7 -0.6
Body mass index (BMI) 0.0 0.2 0.5 -0.7 0.2 -0.0 -0.6 0.2
Impedance of leg (left) 0.1 0.6 1.7 0.5 -0.8 -0.1 1.3 0.7
Leg predicted mass (left) 0.3 1.7 5.0 -2.2 -0.3 -1.4 -0.9 -0.7
Trunk fat mass 0.1 0.5 1.5 -1.2 0.2 -0.3 -1.0 -0.2
Waist circumference 0.2 0.9 2.1 -1.1 1.0 -0.1 -1.4 -0.5
Number of incorrect matches in round 0.2 0.3 0.6 0.4 -0.4 0.8 0.4 -0.5
Past tobacco smoking 0.1 0.2 0.4 0.3 0.5 0.6 -0.0 0.3
Alcohol usually taken with meals 0.1 0.2 0.4 -0.6 -0.5 -0.7 -0.2 -0.1
Nervous feelings 0.1 0.2 0.8 -0.2 -0.2 -0.9 0.4 0.4
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.4 7.1 -1.4 -2.0 -2.7 1.8 -0.8
Hearing difficulty/problems with background noise 0.4 0.6 1.4 -1.1 -0.0 -1.2 -0.4 -0.3
Hair/balding pattern: Pattern 2 0.7 0.9 1.8 -0.5 1.2 -0.1 -1.3 -0.9
Had menopause 1.5 1.9 4.3 -1.7 -1.3 -0.6 -0.1 -2.1
Had other major operations 0.1 0.1 0.3 0.2 -0.1 0.2 0.5 -0.5
Forced vital capacity (FVC) 0.6 2.2 3.7 -1.9 -1.5 -1.9 0.9 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.2 0.4 0.2 -0.4 -0.4 0.3
Ever unenthusiastic/disinterested for a whole week 2.2 2.7 5.5 -1.1 -2.3 -1.5 2.1 0.0
Qualifications: None of the above 1.6 3.4 6.2 -0.8 -2.5 -2.0 2.0 -1.4
Financial difficulties in last 2 years 0.1 0.1 0.2 -0.2 -0.5 0.0 0.5 0.0
Mouth/teeth dental problems 0.2 0.3 1.3 -0.0 0.1 -0.1 -0.5 -1.2
Heart attack 0.3 0.4 0.9 0.1 -1.0 0.4 0.9 0.3
Allergy 0.5 1.1 3.7 -0.1 -0.7 -1.9 1.1 -0.1
Pain all over the body in last month 0.7 0.7 1.3 0.1 -0.6 -1.1 1.0 -1.0
Diabetes (self-reported) 0.8 1.2 3.3 -1.8 -0.2 -0.7 -0.8 -1.2
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.1 1.1 0.6 0.9 0.2 1.0
Medication: Ramipril 0.7 0.9 1.6 -1.1 0.2 -0.6 -1.3 -1.1
Medication: Simvastatin 0.3 0.4 1.6 -1.3 -0.1 0.4 -0.5 0.4
Fluid intelligence score 0.5 1.0 2.8 -1.7 0.1 -0.8 -0.6 -1.2
Illnesses of siblings 0.1 0.2 0.5 0.4 -0.1 -0.4 -0.1 -0.7
Neuroticism score 0.6 1.3 3.3 -0.7 -1.0 -1.8 0.7 -1.2
Weight 0.3 1.4 5.0 -2.2 -0.3 -1.1 -0.9 -0.2
Impedance of arm (right) 0.0 0.1 0.4 0.5 -0.1 -0.2 0.1 -0.6
Arm fat percentage (right) 0.0 0.2 0.5 -0.5 0.4 0.0 -0.7 0.1
Trunk fat-free mass 0.5 2.9 9.6 -3.1 -0.9 -2.0 -0.6 -0.4
Hip circumference 0.1 0.6 1.6 -1.3 0.5 -0.2 -1.1 -0.1
Time employed in main current job 0.2 0.2 0.5 0.4 0.2 0.7 0.4 0.5
Alcohol intake versus 10 years previously 0.4 0.6 2.1 0.2 -0.8 -0.4 -0.3 -1.4
Father’s age at death 0.0 0.0 0.1 -0.1 0.3 0.2 0.0 -0.3
Worrier / anxious feelings 0.1 0.2 0.5 -0.7 0.1 -0.6 0.2 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 2.5 0.1 -1.1 -0.9 1.6 -0.3
Falls in the last year 0.4 0.6 0.9 -0.9 -0.5 -0.7 1.0 0.6
Hair/balding pattern: Pattern 3 1.2 1.8 4.4 1.6 0.4 0.7 1.2 2.1
Number of live births 1.6 2.2 6.8 -2.6 -1.1 -1.1 -0.4 -1.2
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 4.4 -1.6 -1.2 -2.1 0.9 -0.8
Pulse rate 1.1 1.9 4.2 1.0 1.5 1.4 -0.6 2.0
Happiness 0.9 1.0 2.7 0.8 0.4 1.6 -1.0 -0.8
Noisy workplace 1.1 1.3 2.2 1.5 1.4 1.2 -0.7 0.8
Qualifications: A levels/AS levels or equivalent 1.3 2.9 4.7 0.7 1.8 2.2 -1.5 2.0
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.6 1.2 0.9 0.9 0.0 1.0
Mouth/teeth dental problems: Dentures 0.9 1.6 3.5 1.3 0.2 1.5 0.7 1.9
Asthma 0.0 0.1 0.3 0.1 0.0 0.5 0.1 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.8 -1.3 -0.7 -0.8 -0.3 -1.0
Medication: Cholesterol lowering 0.6 0.9 2.4 -1.5 -1.2 -0.7 -0.1 -0.5
Depression (self-reported) 4.2 5.0 10.8 -3.3 -2.5 -1.8 0.2 -2.1
Medication: Lansoprazole 0.3 0.4 1.4 -1.2 -0.3 -0.0 0.4 0.3
Prospective memory result 1.2 1.4 3.3 0.6 -0.6 -1.3 1.8 1.1
Lung cancer (father) 0.7 0.8 2.0 -0.5 -1.4 -0.6 1.1 0.0
Illnesses of mother 1.2 1.5 3.3 0.7 1.3 1.8 -0.3 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 5.7 -1.8 -1.3 -2.4 0.1 -1.8
Pulse wave Arterial Stiffness index 1.1 1.3 2.9 0.8 -0.5 0.7 1.4 1.7
Impedance of arm (left) 0.1 0.3 1.0 1.0 0.0 0.2 0.0 -0.6
Arm fat mass (right) 0.2 0.7 2.3 -1.5 -0.0 -0.5 -0.9 -0.3
Trunk predicted mass 0.5 2.9 9.4 -3.1 -0.8 -1.9 -0.7 -0.4
Standing height 0.5 4.5 13.2 -3.6 -1.1 -2.4 -0.7 -1.2
Length of working week for main job 1.6 1.8 6.1 0.8 0.1 0.3 1.5 2.5
Exposure to tobacco smoke at home 0.5 0.6 1.4 -0.2 1.2 0.0 -1.1 -0.5
Breastfed as a baby 1.8 2.3 7.2 0.6 1.3 1.0 -2.7 -1.1
Tense / ‘highly strung’ 0.3 0.5 1.0 -0.5 -0.7 -1.0 0.9 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.9 4.4 8.4 -1.1 -2.9 -2.5 2.5 0.3
Hair/balding pattern: Pattern 4 0.8 1.9 4.0 -1.2 -1.8 -0.8 -0.2 -2.0
Birth weight of first child 0.4 0.8 1.6 -0.8 -1.3 -0.3 1.1 0.8
Peak expiratory flow (PEF) 1.0 2.2 5.5 -2.3 -1.1 -1.9 0.7 -0.6
Pulse wave reflection index 0.9 1.1 3.1 -1.0 -1.0 -0.7 0.2 -1.8
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 0.3 -0.6 -0.1 0.2 0.1
Loud music exposure frequency 0.2 0.2 0.8 -0.1 -0.9 -0.2 0.2 -0.3
Qualifications: O levels/GCSEs or equivalent 1.8 2.9 5.0 0.1 2.1 1.8 -2.2 1.1
Mouth/teeth dental problems: Bleeding gums 2.3 3.0 4.7 -1.7 -2.2 -1.9 1.9 0.4
Blood clot in the leg (DVT) 0.1 0.1 0.3 -0.3 -0.5 0.2 0.3 0.1
Medication: Paracetamol 0.3 0.5 1.4 0.3 -0.3 1.2 0.4 0.8
Headache pain in last month 0.9 1.5 2.9 1.6 0.3 1.0 1.1 1.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 1.8 1.3 1.3 0.9 -0.4 0.8
Glaucoma (self-reported) 0.1 0.1 0.7 -0.1 0.1 -0.2 0.2 0.8
Gout (self-reported) 0.9 1.2 4.2 1.3 -0.1 0.1 0.6 2.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.2 1.1 0.5 -0.7 -0.5 -0.2
Medication: Amlodipine 0.9 1.2 2.6 1.6 0.8 0.5 -0.1 1.6
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.3 -0.1 -0.6 0.1 0.5 -0.4
Birth weight 2.2 4.9 10.4 -1.0 -3.2 -2.7 2.3 -0.6
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.7 1.3 -0.6 0.3 0.5 0.5
High blood pressure (siblings) 0.1 0.2 0.5 -0.4 0.3 0.2 -0.0 0.7
Forced vital capacity (FVC), Best measure 0.7 2.7 4.5 -2.1 -1.2 -2.0 -0.2 -1.9
Body fat percentage 0.1 0.2 0.6 -0.6 0.3 0.1 -0.8 0.1
Leg fat percentage (right) 0.1 0.3 0.6 -0.8 -0.3 -0.4 0.1 0.8
Arm fat-free mass (right) 0.4 2.3 7.9 -2.8 -0.7 -1.6 -0.7 -0.4
Exposure to tobacco smoke outside home 0.6 0.8 2.4 -1.5 -0.1 -1.2 -0.1 -0.2
Comparative body size at age 10 0.3 0.9 1.8 -0.6 -0.8 -0.8 1.3 0.9
Number of full brothers 0.2 0.2 0.6 -0.4 -0.2 -0.6 0.2 -0.8
Worry too long after embarrassment 0.7 1.2 2.5 -1.6 -0.2 -1.1 -0.6 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 3.9 -0.8 -2.0 -1.6 1.9 0.3
Wheeze or whistling in the chest in last year 0.2 0.4 1.0 0.8 0.5 1.0 0.2 0.4
Number of children fathered 0.5 0.6 2.2 -1.5 0.1 -0.6 -0.2 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 2.6 3.0 4.8 -2.2 -1.7 -1.8 -0.3 -2.0
Age at first live birth 0.2 0.4 1.8 0.1 0.5 0.4 -1.3 -0.1
Pulse wave peak to peak time 1.3 1.6 3.6 -1.1 0.3 -0.9 -1.4 -1.9
Health satisfaction 1.3 1.7 4.6 0.2 -1.7 -0.8 2.1 0.5
Shortness of breath walking on level ground 1.5 1.8 3.8 -1.1 -1.8 -1.0 2.0 0.1
Qualifications: College or University degree 0.5 1.5 3.4 -0.3 1.6 1.1 -1.8 0.4
Eye problems/disorders: None of the above 1.4 1.6 3.2 -0.9 0.8 -0.4 -1.7 -1.8
Mouth/teeth dental problems: Loose teeth 0.5 0.7 1.3 -0.1 1.1 1.1 -0.9 0.2
Emphysema/chronic bronchitis 0.0 0.0 0.1 -0.3 0.2 -0.1 -0.2 0.1
Medication for pain relief, constipation, heartburn 0.3 0.5 1.1 1.0 0.5 -0.8 0.5 0.6
Neck or shoulder pain in last month 2.6 3.7 8.5 1.9 2.0 2.9 -0.0 1.6
Medication: Blood pressure 0.1 0.2 0.3 -0.5 -0.4 0.1 -0.3 -0.6
Angina (self-reported) 1.7 2.3 6.0 1.9 0.8 2.4 -0.5 0.8
Migraine (self-reported) 0.2 0.2 0.8 -0.0 0.1 0.2 0.6 0.9
Medication: Ibuprofen 0.4 0.4 1.2 -1.1 -0.1 -0.5 -0.3 -0.7
Medication: Allopurinol 0.7 0.9 2.9 1.1 -0.1 0.1 0.5 1.7
Medication: Omeprazole 0.3 0.4 0.6 -0.6 0.3 0.5 -0.8 -0.7
Medication: Seretide 50 evohaler 1.0 1.1 3.3 0.2 -0.5 0.3 1.8 1.4
Mean time to correctly identify matches 0.5 1.0 1.9 -1.4 -0.4 -0.1 -0.9 -1.4
Heart disease (mother) 0.2 0.2 0.4 0.0 0.1 -0.1 -0.7 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.9 1.4 -0.5 -0.2 1.1 0.7
Whole body fat mass 0.1 0.6 1.8 -1.3 0.1 -0.2 -1.0 0.0
Leg fat mass (right) 0.2 0.6 2.1 -1.5 -0.4 -0.8 -0.3 0.2
Arm predicted mass (right) 0.4 2.1 7.6 -2.8 -0.6 -1.5 -0.6 -0.2
Pulse rate, automated reading 0.1 0.5 1.4 -0.5 0.8 -0.1 -0.0 1.2
Alcohol intake frequency. 0.0 0.0 0.1 0.2 0.0 -0.0 0.3 -0.0
Comparative height size at age 10 0.3 1.5 3.7 -1.9 -0.4 -1.2 -1.2 -0.9
Number of full sisters 0.1 0.1 0.3 -0.0 -0.5 -0.1 0.5 -0.0
Suffer from ‘nerves’ 1.7 2.6 6.2 -2.1 -1.3 -2.5 0.4 -0.9
Overall health rating 0.1 0.2 0.7 -0.3 -0.3 0.1 0.8 0.5
Chest pain or discomfort 1.9 2.7 4.5 1.9 0.9 1.8 1.3 2.1
Had major operations 0.4 0.4 1.6 1.3 -0.3 -0.4 0.4 -0.2
Age at last live birth 0.3 0.5 1.8 -0.2 0.3 0.2 -1.3 -0.6
Family relationship satisfaction 0.9 1.2 2.7 -1.4 -0.1 0.3 -1.0 -1.7
Leg pain on walking 1.2 1.5 4.8 -2.2 -0.4 -1.2 -0.2 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.6 0.3 1.6 1.4 -0.8 0.6
Commuting to job workplace: Car/motor vehicle 1.2 1.4 2.7 1.7 0.7 1.5 -0.3 1.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.9 -0.1 0.9 0.3 -1.0 -0.1
Medication: Aspirin 0.1 0.1 0.3 -0.5 -0.5 -0.1 0.0 -0.3
Supplements: Vitamin C 0.3 0.4 0.8 -0.1 -0.5 -0.9 0.9 -0.4
Knee pain experienced in last month 0.0 0.1 0.2 0.3 -0.1 0.4 0.2 -0.1
Hypertension (Self-reported) 0.3 0.8 1.3 1.0 1.0 1.1 -0.6 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.0 0.5 0.9 0.7 -1.0 -0.8
Illnesses of father: Heart disease 0.9 1.2 2.0 -0.9 1.4 1.4 -0.9 0.8
Illnesses of siblings: Diabetes 3.5 4.4 7.8 1.2 2.8 2.7 -2.1 1.1
Smoking status: Previous 0.2 0.4 0.9 -0.8 -1.0 -0.3 0.4 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 2.0 -0.8 -0.0 -1.4 -0.4 -0.9
Whole body fat-free mass 0.4 2.2 7.3 -2.7 -0.5 -1.6 -0.8 -0.5
Leg fat-free mass (right) 0.2 1.3 3.8 -1.9 0.2 -1.0 -1.2 -0.6
Arm fat percentage (left) 0.1 0.2 0.7 -0.2 0.6 0.3 -0.8 0.1
Average weekly red wine intake 0.8 1.2 3.9 -1.0 0.7 0.1 -2.0 -0.7
Handedness (chirality/laterality): Left-handed 1.7 2.0 3.2 1.0 -1.3 -1.8 1.8 1.0
Mood swings 0.1 0.1 0.3 -0.2 -0.2 -0.6 0.1 -0.4
Loneliness, isolation 2.6 3.5 6.4 -1.4 -2.5 -2.2 0.9 -1.9
Long-standing illness, disability or infirmity 1.0 1.5 4.9 0.4 -1.4 -0.2 2.2 0.8
Ever had bowel cancer screening 0.8 0.9 1.9 -0.0 1.1 1.1 -1.4 0.5
Diabetes diagnosed by doctor 0.6 0.9 3.4 -1.8 -0.4 -0.7 -0.5 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.8 -1.3 -0.5 -0.1 -0.3 -0.1
Friendships satisfaction 0.5 0.6 1.3 -1.0 0.1 0.4 -0.8 -1.2
Qualifications: nursing, teaching 0.5 0.8 2.1 1.5 0.2 1.1 0.0 0.9
Commuting to job workplace: Walk 0.4 0.5 1.3 -1.0 0.3 0.2 -1.1 -0.2
Eye problems/disorders: Cataract 0.7 0.8 1.5 -0.5 -1.2 -0.3 1.2 0.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.5 0.3 0.7 -0.0 -0.3 -0.1
Medication for cholesterol 0.8 1.3 3.7 0.1 -1.2 -0.9 1.9 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.7 0.8 0.5 0.4 -0.4 -0.2
Back pain experienced in last month 0.6 0.9 1.9 1.3 0.5 1.4 0.1 0.8
Mineral and other dietary supplements 0.0 0.1 0.2 -0.1 0.2 -0.4 -0.2 0.1
Breast cancer (self-reported) 0.8 0.9 2.0 1.1 0.3 -0.1 1.4 1.1
Asthma (self-reported) 0.1 0.2 0.9 0.2 0.4 1.0 -0.3 0.2
Osteoporosis (self-reported) 0.1 0.1 0.3 0.2 -0.5 -0.3 0.5 -0.0
Osteoarthritis (self-reported) 1.6 2.1 5.0 0.5 -2.2 -0.8 2.0 -0.9
Medication: Aspirin 0.2 0.2 0.7 -0.9 -0.2 -0.0 -0.5 -0.4
Medication: Gliclazide 0.8 0.9 2.3 -1.5 -0.8 -0.6 -0.5 -1.1
Illnesses of father: None of the above (group 1) 0.4 0.5 1.4 -0.3 -0.7 -1.2 0.4 -0.4
Smoking status: Current 0.5 0.7 2.3 1.5 0.0 -0.9 0.5 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.4 -0.9 -0.4 -0.7 0.3 -1.2
Whole body water mass 0.4 2.4 7.8 -2.8 -0.6 -1.7 -0.7 -0.5
Leg predicted mass (right) 0.2 1.3 3.7 -1.9 0.2 -1.0 -1.2 -0.7
Arm fat mass (left) 0.1 0.6 2.0 -1.4 0.0 -0.4 -0.9 -0.3
Number of self-reported non-cancer illnesses 0.5 0.9 1.7 1.3 -0.9 -0.5 1.3 0.0
Average weekly champagne plus white wine intake 0.2 0.3 0.9 -0.2 0.1 -0.4 0.6 0.9
Miserableness 2.2 3.9 8.5 -1.4 -2.5 -2.9 1.5 -0.8
Guilty feelings 0.7 1.1 2.1 -0.5 -1.1 -1.3 1.5 0.3
Wears glasses or contact lenses 0.3 0.3 0.9 0.3 0.5 1.0 -0.4 0.2
Ever taken oral contraceptive pill 0.6 0.7 2.0 -1.4 -0.8 -0.6 0.1 -0.8
Hearing aid user 1.3 1.5 2.4 1.1 1.3 1.4 0.4 1.6
Mother’s age at death 1.0 1.3 2.3 -1.3 -0.1 0.1 -1.5 -1.5
Financial situation satisfaction 0.2 0.3 0.8 -0.9 -0.3 0.5 -0.2 -0.4
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.8 1.0 0.9 0.6 -1.4 -0.6
Commuting to job workplace: Public transport 0.0 0.0 0.0 -0.0 0.1 0.1 0.2 0.1
Eye problems/disorders: Glaucoma 1.1 1.3 2.6 0.8 -0.7 -0.5 1.6 1.6
Medication: Blood pressure 0.1 0.3 0.6 0.3 0.4 0.5 -0.4 0.8
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.4 0.1 -1.2 0.1 0.9 -0.4
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.3 -0.6 -0.3 0.2 0.5 -0.0
High cholesterol (Self-reported) 0.4 0.6 1.4 -0.5 -0.7 -0.9 0.3 -1.2
Medication: Bendroflumethiazide 0.6 0.8 1.5 0.6 -0.8 0.0 1.2 1.2
Medication: Paracetamol 0.8 1.2 3.1 0.6 -0.4 1.1 1.0 1.8
Medication: Lisinopril 0.6 0.8 1.8 0.4 1.3 0.6 -1.3 -0.1
Medication: Atorvastatin 0.2 0.2 0.7 0.8 0.2 0.1 0.0 -0.6
Illnesses of father: High blood pressure 0.2 0.2 0.6 0.7 0.3 0.8 -0.1 0.1
Alcohol drinker status: Never 1.0 1.2 2.7 1.0 0.2 -0.1 1.5 1.7
Ever smoked 0.2 0.3 1.2 0.1 -0.4 -1.1 0.4 0.1
Basal metabolic rate 0.4 2.3 7.7 -2.8 -0.6 -1.7 -0.7 -0.4
Leg fat percentage (left) 0.1 0.2 1.1 -0.3 0.0 0.1 -0.0 1.1
Arm fat-free mass (left) 0.5 2.4 8.6 -2.9 -0.7 -1.6 -0.5 -0.2
Number of operations (self-reported) 0.3 0.4 1.1 1.0 -0.4 -0.5 0.8 -0.1
Average weekly beer plus cider intake 0.5 0.8 1.6 0.8 0.7 0.3 1.0 1.3
Irritability 1.1 1.8 4.1 -1.4 -1.1 -2.0 1.3 -0.2
Risk taking 0.3 0.4 1.8 -1.3 0.2 -0.5 -0.1 -0.2
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.3 -0.3 -0.4 -0.1 0.4 1.2
Fractured/broken bones in last 5 years 0.6 0.8 1.7 1.3 0.5 0.4 0.6 1.3
Age started oral contraceptive pill 0.4 0.5 1.4 -1.2 -0.5 0.0 -0.3 -0.9
Diastolic blood pressure, automated reading 0.1 0.4 1.7 0.1 0.5 0.2 0.4 1.3
Ever depressed for a whole week 1.1 1.3 3.1 -1.8 -1.4 -1.0 0.6 -0.5
Unable to work because of sickness or disability 0.3 0.3 1.3 0.2 -0.1 1.1 0.5 0.4
Commuting to job workplace: Cycle 0.5 0.6 1.6 -0.3 -0.1 -0.4 -1.1 -1.3
Myopia 0.1 0.2 0.4 -0.0 0.6 0.3 -0.6 0.2
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.2 -0.5 0.0 -0.2 -0.3 -0.4
Cholesterol lowering medication 0.9 1.3 2.3 0.8 1.4 1.3 -1.5 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.6 -0.8 -0.2 0.4 -0.7 -0.8
Pain experienced in last month 1.0 1.6 4.1 -1.6 -0.8 -2.0 -0.3 -0.9
Supplements: Calcium 0.7 0.8 2.1 0.8 0.2 1.5 0.4 1.1
Basal cell carcinoma (self-reported) 0.9 1.0 2.4 0.6 0.7 1.1 0.8 1.5
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.7 0.3 -0.7 0.6 0.8 0.4
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.1 -0.2 -0.3 0.4 0.1 0.1
Heart disease (siblings) 1.1 1.3 3.3 1.0 -0.2 1.8 0.4 1.5
Alcohol drinker status: Previous 0.7 0.9 2.2 0.4 1.2 1.5 -0.2 0.6
Pack years of smoking 0.1 0.1 0.3 0.1 0.5 -0.4 -0.1 -0.6
Impedance of whole body 0.1 0.3 0.7 0.8 -0.4 -0.0 0.7 -0.1
Leg fat mass (left) 0.1 0.4 1.5 -1.2 -0.2 -0.5 -0.3 0.4
Arm predicted mass (left) 0.6 2.9 9.9 -3.1 -0.8 -1.9 -0.4 -0.1