Hub : Genes

ZNF114

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0677	0.0281	5.2e-05	0.018	0.021	0.031	NA	0.028	0.00009	2.8e-05	4.6e-07	NA	1.6e-06
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0523	0.0211	1.7e-06	0.032	0.053	0.050	NA	0.046	0.00014	1.2e-06	2.5e-06	NA	6.4e-06
3	TCGA	Lung Adenocarcinoma	0.0496	0.0302	8.8e-03	0.005	0.014	0.013	NA	0.007	0.08300	7.6e-03	1.1e-02	NA	4.5e-02
4	TCGA	Testicular Germ Cell Tumors	0.1940	0.1170	6.2e-03	0.067	0.077	0.055	NA	0.063	0.00220	1.1e-03	5.2e-03	NA	3.0e-03
5	TCGA	Uterine Corpus Endometrial Carcinoma	0.3040	0.1260	8.3e-03	-0.010	0.026	0.014	NA	-0.010	0.76000	6.3e-02	1.3e-01	NA	8.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.3	2.6	-1.0	-1.3	-1.6	0.0	-1.2
Bipolar Disorder or Schizophrenia	0.5	1.2	2.1	-0.7	-1.4	-1.4	1.2	-0.4
Depressed Affect (Nagel 2018)	1.0	2.2	4.2	-1.5	-1.3	-2.1	0.8	-1.4
Depression (Nagel 2018)	1.4	2.1	3.5	-1.6	-1.8	-1.9	0.9	-0.8
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.2	-2.0	0.1	-1.0	-1.0	-2.3
Neuroticism (Nagel 2018)	1.0	2.4	4.9	-2.2	-0.8	-2.0	0.3	-1.4
Schizophrenia (2018)	0.3	0.7	2.3	-0.2	-0.9	-0.5	1.5	0.5
Schizophrenia vs Biploar Disorder	0.3	0.3	0.7	0.6	-0.7	0.4	0.9	0.1
Worry (Nagel 2018)	0.3	0.5	1.4	-1.2	0.0	-1.0	-0.2	-0.5
Alzheimer’s Disease (in mother)	0.4	0.4	0.8	-0.5	-0.9	-0.6	0.7	-0.6
Alzheimer’s Disease (in father)	0.5	0.6	1.6	0.2	0.2	-0.9	-0.7	-1.2
Alzheimer’s Disease (including proxy)	0.9	1.4	3.9	-0.5	-0.9	-1.4	-0.0	-2.0
Crohns Disease (2017)	0.5	1.2	2.1	-0.7	1.3	0.5	-1.5	-1.1
Irritable Bowel Disease (IBD)	0.6	1.4	4.7	-0.9	-0.1	-0.4	-1.2	-2.2
Ulcerative Colitis (UC)	1.0	1.9	5.6	-0.7	-1.4	-1.0	-0.6	-2.4
Major Depression (MDD)	0.1	0.1	0.2	0.1	0.0	0.3	-0.2	0.4
Reaction Time	0.3	0.5	1.0	-0.7	-0.2	0.2	-1.0	-0.9
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.7	-1.5	1.0	-0.2	-1.9	-1.8
Breast Cancer	0.8	1.9	3.9	1.1	1.6	2.0	-1.4	0.0
Ovarian Cancer	0.3	0.3	0.9	0.2	0.6	0.6	-1.0	0.0
Prostate Cancer	0.7	1.0	1.8	0.8	1.4	0.8	-1.4	0.3
Age at First Birth	1.1	1.6	3.3	-1.3	0.6	-0.3	-1.6	-1.8
Bipolar Disorder (2011)	0.4	0.4	0.7	-0.7	0.3	-0.5	-0.9	-0.7
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.1	-0.2	-0.3	0.3	-0.6
Coronary Artery Disease (CAD)	3.8	4.6	10.3	-2.0	-3.2	-1.9	1.4	-1.7
Crohns Disease (2012)	0.8	1.3	2.8	0.4	1.6	1.7	-0.8	0.6
Mean Putamen Volume	1.3	1.5	4.7	0.9	-0.1	0.5	1.3	2.2
Fasting Glucose	0.6	0.7	1.7	-1.3	-0.9	-0.9	0.2	0.4
HbA1C	0.4	0.5	1.4	0.7	1.2	0.3	-0.6	-0.1
HDL Cholesterol	1.3	2.1	4.0	1.9	1.4	2.0	-0.4	0.7
LDL Cholesterol	0.4	0.6	1.5	-0.2	0.3	0.5	-1.1	-1.2
Lupus	0.3	0.5	1.3	-0.5	-0.8	-1.1	0.7	-0.0
Neuroticism (2016)	0.6	0.9	2.7	1.0	0.7	-0.3	0.6	1.7
Primary Biliary Cirrhosis	0.8	1.2	2.0	-1.1	-1.2	-1.4	1.0	-0.5
Rheumatoid Arthritis	0.3	0.4	0.9	-1.0	-0.7	-0.4	0.3	0.4
Schizophrenia (2014)	0.6	1.4	2.9	-0.6	-1.7	-1.2	1.5	0.0
Triglycerides	0.9	1.5	4.5	-2.1	-0.7	-1.4	-0.2	-0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	-0.0	-0.0	0.9	0.2	1.1
Ulcerative Colitis	2.0	2.8	5.8	-1.6	-2.4	-1.7	0.6	-1.6
Blood Eosinophil Count	0.1	1.2	3.4	1.8	0.6	0.2	1.2	0.7
Blood Platelet Count	1.6	19.0	28.2	5.0	5.1	5.3	-1.6	3.7
Blood Red Count	0.0	0.3	1.1	-1.1	0.3	-0.6	-0.2	-0.3
Blood White Count	1.4	10.3	17.0	3.4	4.1	3.8	-2.8	0.9
Heel T-Score	0.0	0.1	0.2	0.4	0.4	-0.3	0.0	0.3
BMI	0.1	0.5	1.5	-0.5	0.5	-0.1	-1.2	-0.5
Height	0.3	6.5	21.0	-4.6	-2.2	-2.2	-0.5	-1.3
Waist Hip Ratio (WHR)	0.1	0.7	2.2	0.4	1.5	0.5	-0.8	-0.1
Systolic Blood Pressure	0.6	2.8	5.8	2.4	1.9	1.1	-0.2	1.9
Smoking Status	0.2	0.5	1.0	-0.4	-0.7	-1.0	0.4	-1.0
Allergy or Eczema	0.9	2.4	6.0	-0.2	1.2	2.4	-2.1	0.2
Cardiovascular Disease	0.0	0.0	0.0	0.2	0.1	0.1	-0.0	-0.0
Hypothyroidism (self reported)	0.4	0.8	1.5	1.2	1.1	-0.2	-1.1	0.1
Respiratory disease	0.6	1.3	2.8	1.7	0.8	1.4	0.2	1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.1	-1.8	-0.3	-0.2	-0.4	0.2
Lung FEV1/FVC ratio	0.1	0.7	1.8	0.0	1.3	-0.0	-1.2	-0.3
Lung FVC	0.0	0.2	0.5	-0.6	-0.4	-0.2	0.0	-0.7
Neuroticism	0.4	0.9	1.7	-0.7	-1.1	-1.3	1.1	-0.3
Chronotype (morning person)	0.1	0.3	0.8	0.4	0.2	0.5	-0.9	0.2
Hair Pigment	0.1	1.7	3.0	1.7	-0.5	0.2	1.5	1.7
Tanning	0.1	1.2	3.5	0.8	-1.1	-0.6	1.9	0.6
Hand grip strength (left)	0.6	1.6	4.0	0.8	2.0	0.4	-1.5	0.8
Number of treatments/medications taken	0.1	0.1	0.5	-0.7	-0.4	-0.1	0.2	0.0
Average weekly spirits intake	0.8	1.0	2.5	-0.4	-1.4	-0.6	0.1	-1.6
Sensitivity / hurt feelings	0.9	1.5	2.3	-0.3	-1.5	-1.4	1.2	-1.4
Frequency of depressed mood in last 2 weeks	1.4	1.9	3.2	-1.2	-1.8	-1.8	1.1	-0.8
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.1	0.7	-0.3	0.3	0.9
Relative age of first facial hair	0.2	0.3	0.8	-0.4	-0.6	-0.5	0.9	0.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.0	-0.2	-1.4	-0.4	1.0	-0.7
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.3	-1.3	-1.5	-1.2	0.1	-1.5
Ever had hysterectomy (womb removed)	0.3	0.4	0.8	-0.3	-0.9	-0.6	0.9	0.1
Systolic blood pressure, automated reading	0.5	1.3	2.2	1.4	1.1	1.1	-0.3	1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.4	-1.5	-0.4	-0.8	0.3	-0.0
Angina	1.7	2.3	5.7	2.0	0.9	2.4	-0.5	0.8
Medication for hormone replacement therapy	0.0	0.0	0.0	0.1	0.1	-0.0	0.1	0.2
Vitamin and mineral supplements	0.1	0.2	0.4	-0.7	-0.0	-0.6	-0.1	-0.1
Supplements: Zinc	0.3	0.3	0.7	0.3	-0.8	-0.6	0.3	-0.7
Medication: Co-codamol	0.2	0.3	0.7	-0.9	-0.5	-0.6	0.2	0.3
Medication: Metformin	1.0	1.4	2.9	1.1	1.7	1.4	-0.7	0.5
Diabetes (father)	0.0	0.0	0.1	0.2	0.4	0.2	-0.0	0.1
Diabetes (mother)	0.8	1.0	2.4	1.2	1.6	0.7	-0.6	0.5
Severe depression (siblings)	0.1	0.1	0.2	-0.1	-0.5	-0.4	-0.1	-0.4
Pack years adult smoking proportion	0.1	0.2	0.4	0.6	0.6	-0.2	0.1	-0.3
Impedance of leg (right)	0.2	0.9	2.1	-0.2	-1.4	-0.8	1.4	0.1
Leg fat-free mass (left)	0.3	1.7	4.9	-2.2	-0.3	-1.4	-0.9	-0.8
Trunk fat percentage	0.1	0.2	0.6	-0.5	0.2	-0.0	-0.8	-0.3
Hand grip strength (right)	1.8	4.8	11.2	0.8	3.4	1.8	-2.5	1.6
Townsend deprivation index at recruitment	1.0	1.5	4.5	-0.1	-2.1	-0.3	1.2	-1.1
Current tobacco smoking	0.6	1.0	3.9	2.0	0.0	-0.7	0.7	-0.4
Average weekly fortified wine intake	0.8	0.9	3.2	0.1	1.8	0.5	-1.0	0.3
Maternal smoking around birth	1.9	2.7	5.9	2.4	1.2	1.3	1.0	1.9
Fed-up feelings	0.7	1.3	2.6	0.3	-1.4	-1.2	1.6	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	7.1	-1.3	-2.7	-2.3	1.6	-1.2
Relative age voice broke	0.3	0.5	1.0	0.2	-0.9	-0.1	1.0	0.9
Taking other prescription medications	0.2	0.3	0.8	0.0	-0.9	-0.3	0.8	0.2
Age when periods started (menarche)	0.1	0.3	0.5	-0.5	-0.5	0.3	-0.7	-0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	0.8	0.2	1.1	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	-0.1	0.3	-0.9	-0.7	-0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	-0.8	0.4	0.3	0.8	0.6
Qualifications: CSEs or equivalent	0.3	0.4	1.8	1.3	0.0	-0.0	0.4	0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.6	-0.4	-0.3	0.7	-0.1
High blood pressure	0.1	0.2	0.4	0.6	0.2	0.4	0.0	0.4
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.9	0.3	1.1	2.2	-1.4	0.7
Multivitamins +/- minerals	1.8	2.3	3.8	1.6	1.8	2.0	-1.1	0.7
Stomach or abdominal pain in last month	0.4	0.5	1.2	0.1	1.1	0.5	-0.9	-0.5
Supplements: Glucosamine	1.3	1.7	2.9	0.4	1.7	1.6	-1.7	-0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.5	0.7	0.3	1.2	-0.3	-0.2
Medication: Atenolol	0.1	0.2	0.6	-0.1	-0.4	-0.2	0.8	0.0
Medication: Levothyroxine sodium	0.4	0.7	1.5	0.5	1.2	-0.3	-1.2	-0.2
Sitting height	0.7	4.6	16.4	-4.0	-1.1	-2.2	-0.6	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	0.7	0.3	1.1	0.5	0.6
High blood pressure (mother)	1.4	2.0	3.5	-0.6	-1.9	-1.7	1.7	-0.6
Body mass index (BMI)	0.0	0.2	0.5	-0.7	0.2	-0.0	-0.6	0.2
Impedance of leg (left)	0.1	0.6	1.7	0.5	-0.8	-0.1	1.3	0.7
Leg predicted mass (left)	0.3	1.7	5.0	-2.2	-0.3	-1.4	-0.9	-0.7
Trunk fat mass	0.1	0.5	1.5	-1.2	0.2	-0.3	-1.0	-0.2
Waist circumference	0.2	0.9	2.1	-1.1	1.0	-0.1	-1.4	-0.5
Number of incorrect matches in round	0.2	0.3	0.6	0.4	-0.4	0.8	0.4	-0.5
Past tobacco smoking	0.1	0.2	0.4	0.3	0.5	0.6	-0.0	0.3
Alcohol usually taken with meals	0.1	0.2	0.4	-0.6	-0.5	-0.7	-0.2	-0.1
Nervous feelings	0.1	0.2	0.8	-0.2	-0.2	-0.9	0.4	0.4
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	7.1	-1.4	-2.0	-2.7	1.8	-0.8
Hearing difficulty/problems with background noise	0.4	0.6	1.4	-1.1	-0.0	-1.2	-0.4	-0.3
Hair/balding pattern: Pattern 2	0.7	0.9	1.8	-0.5	1.2	-0.1	-1.3	-0.9
Had menopause	1.5	1.9	4.3	-1.7	-1.3	-0.6	-0.1	-2.1
Had other major operations	0.1	0.1	0.3	0.2	-0.1	0.2	0.5	-0.5
Forced vital capacity (FVC)	0.6	2.2	3.7	-1.9	-1.5	-1.9	0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	0.4	0.2	-0.4	-0.4	0.3
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	5.5	-1.1	-2.3	-1.5	2.1	0.0
Qualifications: None of the above	1.6	3.4	6.2	-0.8	-2.5	-2.0	2.0	-1.4
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.2	-0.5	0.0	0.5	0.0
Mouth/teeth dental problems	0.2	0.3	1.3	-0.0	0.1	-0.1	-0.5	-1.2
Heart attack	0.3	0.4	0.9	0.1	-1.0	0.4	0.9	0.3
Allergy	0.5	1.1	3.7	-0.1	-0.7	-1.9	1.1	-0.1
Pain all over the body in last month	0.7	0.7	1.3	0.1	-0.6	-1.1	1.0	-1.0
Diabetes (self-reported)	0.8	1.2	3.3	-1.8	-0.2	-0.7	-0.8	-1.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	1.1	0.6	0.9	0.2	1.0
Medication: Ramipril	0.7	0.9	1.6	-1.1	0.2	-0.6	-1.3	-1.1
Medication: Simvastatin	0.3	0.4	1.6	-1.3	-0.1	0.4	-0.5	0.4
Fluid intelligence score	0.5	1.0	2.8	-1.7	0.1	-0.8	-0.6	-1.2
Illnesses of siblings	0.1	0.2	0.5	0.4	-0.1	-0.4	-0.1	-0.7
Neuroticism score	0.6	1.3	3.3	-0.7	-1.0	-1.8	0.7	-1.2
Weight	0.3	1.4	5.0	-2.2	-0.3	-1.1	-0.9	-0.2
Impedance of arm (right)	0.0	0.1	0.4	0.5	-0.1	-0.2	0.1	-0.6
Arm fat percentage (right)	0.0	0.2	0.5	-0.5	0.4	0.0	-0.7	0.1
Trunk fat-free mass	0.5	2.9	9.6	-3.1	-0.9	-2.0	-0.6	-0.4
Hip circumference	0.1	0.6	1.6	-1.3	0.5	-0.2	-1.1	-0.1
Time employed in main current job	0.2	0.2	0.5	0.4	0.2	0.7	0.4	0.5
Alcohol intake versus 10 years previously	0.4	0.6	2.1	0.2	-0.8	-0.4	-0.3	-1.4
Father’s age at death	0.0	0.0	0.1	-0.1	0.3	0.2	0.0	-0.3
Worrier / anxious feelings	0.1	0.2	0.5	-0.7	0.1	-0.6	0.2	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.5	0.1	-1.1	-0.9	1.6	-0.3
Falls in the last year	0.4	0.6	0.9	-0.9	-0.5	-0.7	1.0	0.6
Hair/balding pattern: Pattern 3	1.2	1.8	4.4	1.6	0.4	0.7	1.2	2.1
Number of live births	1.6	2.2	6.8	-2.6	-1.1	-1.1	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.4	-1.6	-1.2	-2.1	0.9	-0.8
Pulse rate	1.1	1.9	4.2	1.0	1.5	1.4	-0.6	2.0
Happiness	0.9	1.0	2.7	0.8	0.4	1.6	-1.0	-0.8
Noisy workplace	1.1	1.3	2.2	1.5	1.4	1.2	-0.7	0.8
Qualifications: A levels/AS levels or equivalent	1.3	2.9	4.7	0.7	1.8	2.2	-1.5	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	1.2	0.9	0.9	0.0	1.0
Mouth/teeth dental problems: Dentures	0.9	1.6	3.5	1.3	0.2	1.5	0.7	1.9
Asthma	0.0	0.1	0.3	0.1	0.0	0.5	0.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.8	-1.3	-0.7	-0.8	-0.3	-1.0
Medication: Cholesterol lowering	0.6	0.9	2.4	-1.5	-1.2	-0.7	-0.1	-0.5
Depression (self-reported)	4.2	5.0	10.8	-3.3	-2.5	-1.8	0.2	-2.1
Medication: Lansoprazole	0.3	0.4	1.4	-1.2	-0.3	-0.0	0.4	0.3
Prospective memory result	1.2	1.4	3.3	0.6	-0.6	-1.3	1.8	1.1
Lung cancer (father)	0.7	0.8	2.0	-0.5	-1.4	-0.6	1.1	0.0
Illnesses of mother	1.2	1.5	3.3	0.7	1.3	1.8	-0.3	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	5.7	-1.8	-1.3	-2.4	0.1	-1.8
Pulse wave Arterial Stiffness index	1.1	1.3	2.9	0.8	-0.5	0.7	1.4	1.7
Impedance of arm (left)	0.1	0.3	1.0	1.0	0.0	0.2	0.0	-0.6
Arm fat mass (right)	0.2	0.7	2.3	-1.5	-0.0	-0.5	-0.9	-0.3
Trunk predicted mass	0.5	2.9	9.4	-3.1	-0.8	-1.9	-0.7	-0.4
Standing height	0.5	4.5	13.2	-3.6	-1.1	-2.4	-0.7	-1.2
Length of working week for main job	1.6	1.8	6.1	0.8	0.1	0.3	1.5	2.5
Exposure to tobacco smoke at home	0.5	0.6	1.4	-0.2	1.2	0.0	-1.1	-0.5
Breastfed as a baby	1.8	2.3	7.2	0.6	1.3	1.0	-2.7	-1.1
Tense / ‘highly strung’	0.3	0.5	1.0	-0.5	-0.7	-1.0	0.9	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.4	8.4	-1.1	-2.9	-2.5	2.5	0.3
Hair/balding pattern: Pattern 4	0.8	1.9	4.0	-1.2	-1.8	-0.8	-0.2	-2.0
Birth weight of first child	0.4	0.8	1.6	-0.8	-1.3	-0.3	1.1	0.8
Peak expiratory flow (PEF)	1.0	2.2	5.5	-2.3	-1.1	-1.9	0.7	-0.6
Pulse wave reflection index	0.9	1.1	3.1	-1.0	-1.0	-0.7	0.2	-1.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.3	-0.6	-0.1	0.2	0.1
Loud music exposure frequency	0.2	0.2	0.8	-0.1	-0.9	-0.2	0.2	-0.3
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.0	0.1	2.1	1.8	-2.2	1.1
Mouth/teeth dental problems: Bleeding gums	2.3	3.0	4.7	-1.7	-2.2	-1.9	1.9	0.4
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.3	-0.5	0.2	0.3	0.1
Medication: Paracetamol	0.3	0.5	1.4	0.3	-0.3	1.2	0.4	0.8
Headache pain in last month	0.9	1.5	2.9	1.6	0.3	1.0	1.1	1.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.8	1.3	1.3	0.9	-0.4	0.8
Glaucoma (self-reported)	0.1	0.1	0.7	-0.1	0.1	-0.2	0.2	0.8
Gout (self-reported)	0.9	1.2	4.2	1.3	-0.1	0.1	0.6	2.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	1.1	0.5	-0.7	-0.5	-0.2
Medication: Amlodipine	0.9	1.2	2.6	1.6	0.8	0.5	-0.1	1.6
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	-0.1	-0.6	0.1	0.5	-0.4
Birth weight	2.2	4.9	10.4	-1.0	-3.2	-2.7	2.3	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.7	1.3	-0.6	0.3	0.5	0.5
High blood pressure (siblings)	0.1	0.2	0.5	-0.4	0.3	0.2	-0.0	0.7
Forced vital capacity (FVC), Best measure	0.7	2.7	4.5	-2.1	-1.2	-2.0	-0.2	-1.9
Body fat percentage	0.1	0.2	0.6	-0.6	0.3	0.1	-0.8	0.1
Leg fat percentage (right)	0.1	0.3	0.6	-0.8	-0.3	-0.4	0.1	0.8
Arm fat-free mass (right)	0.4	2.3	7.9	-2.8	-0.7	-1.6	-0.7	-0.4
Exposure to tobacco smoke outside home	0.6	0.8	2.4	-1.5	-0.1	-1.2	-0.1	-0.2
Comparative body size at age 10	0.3	0.9	1.8	-0.6	-0.8	-0.8	1.3	0.9
Number of full brothers	0.2	0.2	0.6	-0.4	-0.2	-0.6	0.2	-0.8
Worry too long after embarrassment	0.7	1.2	2.5	-1.6	-0.2	-1.1	-0.6	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.9	-0.8	-2.0	-1.6	1.9	0.3
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	0.8	0.5	1.0	0.2	0.4
Number of children fathered	0.5	0.6	2.2	-1.5	0.1	-0.6	-0.2	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	4.8	-2.2	-1.7	-1.8	-0.3	-2.0
Age at first live birth	0.2	0.4	1.8	0.1	0.5	0.4	-1.3	-0.1
Pulse wave peak to peak time	1.3	1.6	3.6	-1.1	0.3	-0.9	-1.4	-1.9
Health satisfaction	1.3	1.7	4.6	0.2	-1.7	-0.8	2.1	0.5
Shortness of breath walking on level ground	1.5	1.8	3.8	-1.1	-1.8	-1.0	2.0	0.1
Qualifications: College or University degree	0.5	1.5	3.4	-0.3	1.6	1.1	-1.8	0.4
Eye problems/disorders: None of the above	1.4	1.6	3.2	-0.9	0.8	-0.4	-1.7	-1.8
Mouth/teeth dental problems: Loose teeth	0.5	0.7	1.3	-0.1	1.1	1.1	-0.9	0.2
Emphysema/chronic bronchitis	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.2	0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	1.0	0.5	-0.8	0.5	0.6
Neck or shoulder pain in last month	2.6	3.7	8.5	1.9	2.0	2.9	-0.0	1.6
Medication: Blood pressure	0.1	0.2	0.3	-0.5	-0.4	0.1	-0.3	-0.6
Angina (self-reported)	1.7	2.3	6.0	1.9	0.8	2.4	-0.5	0.8
Migraine (self-reported)	0.2	0.2	0.8	-0.0	0.1	0.2	0.6	0.9
Medication: Ibuprofen	0.4	0.4	1.2	-1.1	-0.1	-0.5	-0.3	-0.7
Medication: Allopurinol	0.7	0.9	2.9	1.1	-0.1	0.1	0.5	1.7
Medication: Omeprazole	0.3	0.4	0.6	-0.6	0.3	0.5	-0.8	-0.7
Medication: Seretide 50 evohaler	1.0	1.1	3.3	0.2	-0.5	0.3	1.8	1.4
Mean time to correctly identify matches	0.5	1.0	1.9	-1.4	-0.4	-0.1	-0.9	-1.4
Heart disease (mother)	0.2	0.2	0.4	0.0	0.1	-0.1	-0.7	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.9	1.4	-0.5	-0.2	1.1	0.7
Whole body fat mass	0.1	0.6	1.8	-1.3	0.1	-0.2	-1.0	0.0
Leg fat mass (right)	0.2	0.6	2.1	-1.5	-0.4	-0.8	-0.3	0.2
Arm predicted mass (right)	0.4	2.1	7.6	-2.8	-0.6	-1.5	-0.6	-0.2
Pulse rate, automated reading	0.1	0.5	1.4	-0.5	0.8	-0.1	-0.0	1.2
Alcohol intake frequency.	0.0	0.0	0.1	0.2	0.0	-0.0	0.3	-0.0
Comparative height size at age 10	0.3	1.5	3.7	-1.9	-0.4	-1.2	-1.2	-0.9
Number of full sisters	0.1	0.1	0.3	-0.0	-0.5	-0.1	0.5	-0.0
Suffer from ‘nerves’	1.7	2.6	6.2	-2.1	-1.3	-2.5	0.4	-0.9
Overall health rating	0.1	0.2	0.7	-0.3	-0.3	0.1	0.8	0.5
Chest pain or discomfort	1.9	2.7	4.5	1.9	0.9	1.8	1.3	2.1
Had major operations	0.4	0.4	1.6	1.3	-0.3	-0.4	0.4	-0.2
Age at last live birth	0.3	0.5	1.8	-0.2	0.3	0.2	-1.3	-0.6
Family relationship satisfaction	0.9	1.2	2.7	-1.4	-0.1	0.3	-1.0	-1.7
Leg pain on walking	1.2	1.5	4.8	-2.2	-0.4	-1.2	-0.2	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.6	0.3	1.6	1.4	-0.8	0.6
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.7	1.7	0.7	1.5	-0.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	-0.1	0.9	0.3	-1.0	-0.1
Medication: Aspirin	0.1	0.1	0.3	-0.5	-0.5	-0.1	0.0	-0.3
Supplements: Vitamin C	0.3	0.4	0.8	-0.1	-0.5	-0.9	0.9	-0.4
Knee pain experienced in last month	0.0	0.1	0.2	0.3	-0.1	0.4	0.2	-0.1
Hypertension (Self-reported)	0.3	0.8	1.3	1.0	1.0	1.1	-0.6	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	0.5	0.9	0.7	-1.0	-0.8
Illnesses of father: Heart disease	0.9	1.2	2.0	-0.9	1.4	1.4	-0.9	0.8
Illnesses of siblings: Diabetes	3.5	4.4	7.8	1.2	2.8	2.7	-2.1	1.1
Smoking status: Previous	0.2	0.4	0.9	-0.8	-1.0	-0.3	0.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.0	-0.8	-0.0	-1.4	-0.4	-0.9
Whole body fat-free mass	0.4	2.2	7.3	-2.7	-0.5	-1.6	-0.8	-0.5
Leg fat-free mass (right)	0.2	1.3	3.8	-1.9	0.2	-1.0	-1.2	-0.6
Arm fat percentage (left)	0.1	0.2	0.7	-0.2	0.6	0.3	-0.8	0.1
Average weekly red wine intake	0.8	1.2	3.9	-1.0	0.7	0.1	-2.0	-0.7
Handedness (chirality/laterality): Left-handed	1.7	2.0	3.2	1.0	-1.3	-1.8	1.8	1.0
Mood swings	0.1	0.1	0.3	-0.2	-0.2	-0.6	0.1	-0.4
Loneliness, isolation	2.6	3.5	6.4	-1.4	-2.5	-2.2	0.9	-1.9
Long-standing illness, disability or infirmity	1.0	1.5	4.9	0.4	-1.4	-0.2	2.2	0.8
Ever had bowel cancer screening	0.8	0.9	1.9	-0.0	1.1	1.1	-1.4	0.5
Diabetes diagnosed by doctor	0.6	0.9	3.4	-1.8	-0.4	-0.7	-0.5	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.8	-1.3	-0.5	-0.1	-0.3	-0.1
Friendships satisfaction	0.5	0.6	1.3	-1.0	0.1	0.4	-0.8	-1.2
Qualifications: nursing, teaching	0.5	0.8	2.1	1.5	0.2	1.1	0.0	0.9
Commuting to job workplace: Walk	0.4	0.5	1.3	-1.0	0.3	0.2	-1.1	-0.2
Eye problems/disorders: Cataract	0.7	0.8	1.5	-0.5	-1.2	-0.3	1.2	0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.5	0.3	0.7	-0.0	-0.3	-0.1
Medication for cholesterol	0.8	1.3	3.7	0.1	-1.2	-0.9	1.9	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.8	0.5	0.4	-0.4	-0.2
Back pain experienced in last month	0.6	0.9	1.9	1.3	0.5	1.4	0.1	0.8
Mineral and other dietary supplements	0.0	0.1	0.2	-0.1	0.2	-0.4	-0.2	0.1
Breast cancer (self-reported)	0.8	0.9	2.0	1.1	0.3	-0.1	1.4	1.1
Asthma (self-reported)	0.1	0.2	0.9	0.2	0.4	1.0	-0.3	0.2
Osteoporosis (self-reported)	0.1	0.1	0.3	0.2	-0.5	-0.3	0.5	-0.0
Osteoarthritis (self-reported)	1.6	2.1	5.0	0.5	-2.2	-0.8	2.0	-0.9
Medication: Aspirin	0.2	0.2	0.7	-0.9	-0.2	-0.0	-0.5	-0.4
Medication: Gliclazide	0.8	0.9	2.3	-1.5	-0.8	-0.6	-0.5	-1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.3	-0.7	-1.2	0.4	-0.4
Smoking status: Current	0.5	0.7	2.3	1.5	0.0	-0.9	0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	-0.9	-0.4	-0.7	0.3	-1.2
Whole body water mass	0.4	2.4	7.8	-2.8	-0.6	-1.7	-0.7	-0.5
Leg predicted mass (right)	0.2	1.3	3.7	-1.9	0.2	-1.0	-1.2	-0.7
Arm fat mass (left)	0.1	0.6	2.0	-1.4	0.0	-0.4	-0.9	-0.3
Number of self-reported non-cancer illnesses	0.5	0.9	1.7	1.3	-0.9	-0.5	1.3	0.0
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.2	0.1	-0.4	0.6	0.9
Miserableness	2.2	3.9	8.5	-1.4	-2.5	-2.9	1.5	-0.8
Guilty feelings	0.7	1.1	2.1	-0.5	-1.1	-1.3	1.5	0.3
Wears glasses or contact lenses	0.3	0.3	0.9	0.3	0.5	1.0	-0.4	0.2
Ever taken oral contraceptive pill	0.6	0.7	2.0	-1.4	-0.8	-0.6	0.1	-0.8
Hearing aid user	1.3	1.5	2.4	1.1	1.3	1.4	0.4	1.6
Mother’s age at death	1.0	1.3	2.3	-1.3	-0.1	0.1	-1.5	-1.5
Financial situation satisfaction	0.2	0.3	0.8	-0.9	-0.3	0.5	-0.2	-0.4
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	1.0	0.9	0.6	-1.4	-0.6
Commuting to job workplace: Public transport	0.0	0.0	0.0	-0.0	0.1	0.1	0.2	0.1
Eye problems/disorders: Glaucoma	1.1	1.3	2.6	0.8	-0.7	-0.5	1.6	1.6
Medication: Blood pressure	0.1	0.3	0.6	0.3	0.4	0.5	-0.4	0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	0.1	-1.2	0.1	0.9	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.6	-0.3	0.2	0.5	-0.0
High cholesterol (Self-reported)	0.4	0.6	1.4	-0.5	-0.7	-0.9	0.3	-1.2
Medication: Bendroflumethiazide	0.6	0.8	1.5	0.6	-0.8	0.0	1.2	1.2
Medication: Paracetamol	0.8	1.2	3.1	0.6	-0.4	1.1	1.0	1.8
Medication: Lisinopril	0.6	0.8	1.8	0.4	1.3	0.6	-1.3	-0.1
Medication: Atorvastatin	0.2	0.2	0.7	0.8	0.2	0.1	0.0	-0.6
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.7	0.3	0.8	-0.1	0.1
Alcohol drinker status: Never	1.0	1.2	2.7	1.0	0.2	-0.1	1.5	1.7
Ever smoked	0.2	0.3	1.2	0.1	-0.4	-1.1	0.4	0.1
Basal metabolic rate	0.4	2.3	7.7	-2.8	-0.6	-1.7	-0.7	-0.4
Leg fat percentage (left)	0.1	0.2	1.1	-0.3	0.0	0.1	-0.0	1.1
Arm fat-free mass (left)	0.5	2.4	8.6	-2.9	-0.7	-1.6	-0.5	-0.2
Number of operations (self-reported)	0.3	0.4	1.1	1.0	-0.4	-0.5	0.8	-0.1
Average weekly beer plus cider intake	0.5	0.8	1.6	0.8	0.7	0.3	1.0	1.3
Irritability	1.1	1.8	4.1	-1.4	-1.1	-2.0	1.3	-0.2
Risk taking	0.3	0.4	1.8	-1.3	0.2	-0.5	-0.1	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.3	-0.3	-0.4	-0.1	0.4	1.2
Fractured/broken bones in last 5 years	0.6	0.8	1.7	1.3	0.5	0.4	0.6	1.3
Age started oral contraceptive pill	0.4	0.5	1.4	-1.2	-0.5	0.0	-0.3	-0.9
Diastolic blood pressure, automated reading	0.1	0.4	1.7	0.1	0.5	0.2	0.4	1.3
Ever depressed for a whole week	1.1	1.3	3.1	-1.8	-1.4	-1.0	0.6	-0.5
Unable to work because of sickness or disability	0.3	0.3	1.3	0.2	-0.1	1.1	0.5	0.4
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.3	-0.1	-0.4	-1.1	-1.3
Myopia	0.1	0.2	0.4	-0.0	0.6	0.3	-0.6	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.5	0.0	-0.2	-0.3	-0.4
Cholesterol lowering medication	0.9	1.3	2.3	0.8	1.4	1.3	-1.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	-0.8	-0.2	0.4	-0.7	-0.8
Pain experienced in last month	1.0	1.6	4.1	-1.6	-0.8	-2.0	-0.3	-0.9
Supplements: Calcium	0.7	0.8	2.1	0.8	0.2	1.5	0.4	1.1
Basal cell carcinoma (self-reported)	0.9	1.0	2.4	0.6	0.7	1.1	0.8	1.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	0.3	-0.7	0.6	0.8	0.4
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	-0.2	-0.3	0.4	0.1	0.1
Heart disease (siblings)	1.1	1.3	3.3	1.0	-0.2	1.8	0.4	1.5
Alcohol drinker status: Previous	0.7	0.9	2.2	0.4	1.2	1.5	-0.2	0.6
Pack years of smoking	0.1	0.1	0.3	0.1	0.5	-0.4	-0.1	-0.6
Impedance of whole body	0.1	0.3	0.7	0.8	-0.4	-0.0	0.7	-0.1
Leg fat mass (left)	0.1	0.4	1.5	-1.2	-0.2	-0.5	-0.3	0.4
Arm predicted mass (left)	0.6	2.9	9.9	-3.1	-0.8	-1.9	-0.4	-0.1