Hub : Genes

ZNF260

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1020 0.0340 2.2e-07 0.077 0.062 0.077 0.066 0.069 1.3e-09 5.3e-08 1.0e-09 1.8e-08 8.9e-09
2 GTEx Artery Tibial 0.0852 0.0355 2.5e-04 0.023 NA 0.014 NA 0.020 5.9e-03 NA 2.8e-02 NA 9.5e-03
3 GTEx Cells EBV-transformed lymphocytes 0.2610 0.0930 1.6e-03 0.087 NA 0.109 NA 0.131 9.1e-04 NA 2.0e-04 NA 4.8e-05
4 GTEx Cells Transformed fibroblasts 0.1210 0.0480 2.8e-04 0.072 NA 0.059 NA 0.078 4.5e-06 NA 3.1e-05 NA 1.9e-06
5 GTEx Esophagus Mucosa 0.3400 0.0670 4.7e-15 0.312 NA 0.300 NA 0.308 2.5e-21 NA 2.2e-20 NA 4.9e-21
6 GTEx Esophagus Muscularis 0.0660 0.0310 5.3e-03 0.098 NA 0.072 NA 0.091 1.6e-06 NA 3.9e-05 NA 3.6e-06
7 GTEx Nerve Tibial 0.0554 0.0249 2.6e-03 0.023 NA 0.024 NA 0.023 9.2e-03 NA 7.4e-03 NA 8.6e-03
8 GTEx Pancreas 0.1170 0.0480 1.2e-03 0.055 NA 0.041 NA 0.056 2.3e-03 NA 7.6e-03 NA 2.1e-03
9 GTEx Pituitary 0.3980 0.2020 1.8e-03 0.112 NA 0.055 NA 0.083 9.7e-04 NA 1.6e-02 NA 4.1e-03
10 GTEx Prostate 0.2330 0.0770 1.8e-04 0.174 NA 0.171 NA 0.156 3.8e-05 NA 4.4e-05 NA 9.9e-05
11 GTEx Skin Not Sun Exposed Suprapubic 0.0840 0.0430 5.4e-03 0.016 NA 0.007 NA 0.010 4.1e-02 NA 1.2e-01 NA 8.4e-02
12 GTEx Thyroid 0.0710 0.0290 6.0e-04 0.081 NA 0.088 NA 0.084 8.8e-07 NA 3.0e-07 NA 5.7e-07
13 NTR Blood 0.0339 0.0113 3.6e-08 0.017 0.028 0.025 0.028 0.022 3.1e-06 1.3e-09 1.1e-08 2.3e-09 1.0e-07
14 TCGA Brain Lower Grade Glioma 0.0565 0.0295 5.5e-05 0.037 0.038 0.024 NA 0.042 4.5e-05 3.5e-05 8.3e-04 NA 1.5e-05
15 TCGA Liver Hepatocellular Carcinoma 0.0990 0.0580 5.1e-03 0.014 0.017 0.005 NA 0.000 7.2e-02 5.0e-02 1.9e-01 NA 3.1e-01
16 TCGA Pheochromocytoma and Paraganglioma 0.1210 0.0640 4.2e-04 0.099 0.100 0.074 NA 0.089 9.8e-05 8.6e-05 7.0e-04 NA 2.1e-04
17 TCGA Prostate Adenocarcinoma 0.1024 0.0628 2.1e-04 0.023 0.040 0.038 NA 0.037 1.7e-03 4.6e-05 7.3e-05 NA 8.8e-05
18 TCGA Thyroid Carcinoma 0.1080 0.0440 2.1e-08 0.092 0.079 0.077 NA 0.079 2.9e-09 3.9e-08 6.3e-08 NA 3.9e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bipolar Disorder (2018) 0.5 0.9 2.3 0.5 -1.5 0.6 -0.6 -0.9 -0.7 -0.1 0.9 -0.3 -1.3 -0.2 -1.3 1.0 -0.8 0.1 -1.3 -1.2 -1.3
Bipolar Disorder or Schizophrenia 0.4 1.0 2.6 1.0 -1.2 1.0 -1.1 -1.2 -1.0 -0.1 1.6 -0.7 -0.9 -1.2 -1.5 0.1 -1.1 -0.1 -1.4 -0.7 -0.7
Depressed Affect (Nagel 2018) 0.8 1.7 10.1 0.5 -0.3 -0.8 1.7 0.4 0.4 1.7 1.8 1.8 -0.0 1.2 0.3 1.6 0.7 3.2 1.4 0.1 0.1
Depression (Nagel 2018) 2.4 3.5 11.9 1.1 0.3 -1.5 3.0 1.3 1.4 2.6 1.4 3.0 1.0 2.8 1.1 0.8 1.5 3.5 2.1 0.4 0.4
Intelligence (Savage-Jansen 2018) 2.2 6.9 11.3 3.4 0.8 -1.9 3.3 3.1 3.4 3.3 2.2 3.1 2.1 2.5 2.4 -0.8 3.0 2.5 2.7 2.3 2.7
Neuroticism (Nagel 2018) 0.3 0.7 2.2 -0.8 -0.9 -0.8 0.3 -1.1 -1.2 -0.2 0.4 -0.1 -0.9 0.1 -1.1 1.5 -1.0 1.2 -0.2 -0.4 -1.0
Schizophrenia (2018) 0.3 0.6 1.8 0.9 -0.4 0.8 -0.9 -0.8 -0.7 -0.1 1.3 -0.7 -0.1 -1.3 -0.9 -0.7 -0.7 -0.2 -0.8 0.1 0.1
Schizophrenia vs Biploar Disorder 0.4 0.5 2.0 -0.2 0.3 1.4 -1.4 -0.5 -0.6 -0.5 0.8 -1.0 0.5 -1.2 -0.3 -0.9 -0.2 -0.6 -0.4 -0.1 0.5
Worry (Nagel 2018) 0.3 0.7 2.0 -0.8 -1.0 0.1 -0.3 -1.3 -1.3 -1.1 -0.4 -0.9 -0.7 -0.4 -1.2 0.6 -1.4 0.1 -0.6 0.2 -0.6
Alzheimer’s Disease (in mother) 1.8 2.2 10.8 -1.2 -2.1 0.9 -0.2 -1.3 -1.1 -0.5 0.2 0.1 -2.7 -0.3 -1.6 3.3 -1.4 0.8 -0.9 -1.6 -1.5
Alzheimer’s Disease (in father) 0.8 0.9 1.3 0.7 1.1 -1.1 0.8 1.0 1.0 0.8 0.4 0.8 1.1 0.6 1.1 -1.1 1.1 0.4 1.0 1.1 1.0
Alzheimer’s Disease (including proxy) 0.4 0.6 3.0 -0.5 -1.2 0.3 0.3 -0.6 -0.4 0.0 0.7 0.2 -1.3 -0.1 -0.9 1.7 -0.6 0.7 -0.4 -0.6 -0.6
Crohns Disease (2017) 3.5 7.7 12.2 -3.2 -3.4 2.2 -3.1 -2.5 -2.5 -3.1 -1.6 -2.9 -2.9 -2.8 -2.4 3.5 -2.4 -2.1 -3.1 -2.7 -3.0
Irritable Bowel Disease (IBD) 0.6 1.4 4.0 -1.8 -1.9 0.3 -0.8 -1.2 -1.2 -1.4 -0.7 -1.2 -0.7 -1.2 -1.0 2.0 -1.1 0.2 -0.7 -0.9 -1.1
Ulcerative Colitis (UC) 0.5 0.8 4.7 0.3 -0.3 -1.3 1.3 0.3 0.3 0.8 0.9 0.7 1.1 0.2 0.5 0.2 0.5 2.2 1.3 0.6 0.8
Major Depression (MDD) 2.5 3.0 7.3 1.7 1.3 -2.4 2.5 1.6 1.5 1.8 0.4 2.7 0.4 2.2 1.6 0.2 1.6 2.3 2.1 1.4 0.8
Reaction Time 2.4 4.6 10.4 1.1 3.2 -3.1 2.2 1.7 1.5 2.5 1.4 2.1 1.6 2.3 1.9 -2.2 1.9 2.5 2.5 1.7 1.6
Verbal and Numeric Reasoning (VNR) 1.5 3.6 5.9 2.4 1.0 -1.8 2.3 2.2 2.4 2.2 1.1 2.2 2.1 1.4 1.7 -1.2 2.0 1.5 1.9 1.8 2.1
Breast Cancer 1.1 2.6 6.8 0.8 2.5 -2.6 1.4 1.6 1.5 1.1 -0.1 1.3 1.8 1.7 1.7 -2.3 1.4 0.7 1.7 1.5 1.6
Ovarian Cancer 1.8 2.4 4.3 -2.0 -0.5 0.9 -1.4 -1.7 -1.9 -1.7 -1.7 -1.2 -1.8 -1.8 -1.3 1.5 -1.7 -1.2 -1.4 -1.5 -2.1
Prostate Cancer 0.4 0.5 1.1 -0.2 -0.6 0.5 -1.1 -0.8 -0.9 -0.7 -0.5 -0.7 -0.3 -1.0 -0.9 -0.4 -0.8 -0.8 -0.9 -0.9 -0.5
Age at First Birth 0.2 0.2 0.7 0.6 -0.2 0.3 -0.1 0.8 0.8 0.2 -0.0 0.4 0.0 0.1 0.8 0.8 0.7 -0.1 0.2 0.2 0.3
Bipolar Disorder (2011) 0.6 0.6 3.3 1.5 -0.7 -0.2 0.4 0.0 0.3 1.0 1.8 0.3 -0.9 0.9 -0.5 0.4 -0.1 0.1 -0.6 -0.5 -0.3
Body Mass Index (BMI) (2010) 0.9 1.3 3.3 1.8 0.8 -0.3 0.7 1.1 1.1 1.3 1.7 0.9 1.3 0.7 1.0 -1.0 1.2 0.7 1.1 1.1 1.4
Coronary Artery Disease (CAD) 0.4 0.5 2.3 -0.0 0.9 -0.9 0.3 0.1 -0.1 0.9 1.5 0.4 0.9 0.7 0.3 -0.6 0.4 1.5 0.6 -0.2 0.4
Crohns Disease (2012) 4.5 7.2 17.2 -2.2 -3.4 2.0 -2.4 -2.7 -2.6 -2.0 0.1 -2.1 -3.7 -2.2 -2.8 4.2 -2.3 -0.5 -3.0 -3.3 -3.5
Mean Putamen Volume 0.7 0.8 4.3 -0.1 -0.2 -0.2 0.6 -0.4 -0.4 1.3 1.7 0.8 -0.4 0.6 -0.4 1.1 0.1 2.1 0.3 -1.1 -0.6
Fasting Glucose 0.4 0.5 2.1 0.9 -0.4 0.1 0.4 0.3 0.3 0.9 1.5 0.6 0.3 -0.0 0.2 0.8 0.6 1.4 0.6 0.2 0.7
HbA1C 3.9 4.3 8.2 -2.3 -1.8 2.9 -2.6 -2.1 -2.2 -1.7 -0.8 -2.4 -2.0 -2.2 -1.8 1.6 -1.8 -1.4 -2.2 -2.5 -2.1
HDL Cholesterol 1.6 2.7 4.7 -1.8 -1.5 0.6 -1.3 -1.6 -1.6 -2.0 -2.1 -1.6 -2.2 -1.9 -1.4 1.2 -1.7 -1.7 -1.7 -1.3 -1.8
LDL Cholesterol 0.1 0.2 2.3 -0.7 0.1 -1.5 0.2 -0.3 -0.3 0.0 -0.1 -0.0 0.3 0.1 -0.1 0.1 -0.2 0.4 0.1 -0.1 -0.4
Lupus 0.3 0.4 3.0 -0.5 0.6 -1.7 -0.3 -0.2 -0.3 -0.3 0.7 -0.2 1.2 -0.2 0.0 -0.5 -0.2 0.2 0.3 0.9 0.8
Neuroticism (2016) 0.4 0.5 3.6 0.0 -0.2 -1.9 1.1 -0.2 -0.2 0.3 -0.2 1.0 -0.4 -0.1 -0.2 0.7 -0.1 1.3 0.5 0.1 -0.5
Primary Biliary Cirrhosis 6.8 9.7 15.7 -3.3 -3.1 2.3 -3.1 -3.8 -4.0 -3.2 -1.8 -3.5 -3.2 -3.0 -3.5 2.6 -3.6 -1.9 -3.3 -2.9 -3.2
Rheumatoid Arthritis 1.4 1.9 3.4 1.6 1.2 -0.6 0.7 1.7 1.7 1.6 1.8 0.6 1.7 1.4 1.6 -1.7 1.8 0.2 1.0 1.1 1.6
Schizophrenia (2014) 0.5 1.1 2.9 0.7 -0.8 1.6 -1.7 -1.1 -1.0 -0.8 0.7 -1.2 -0.3 -1.5 -1.2 -0.7 -1.1 -1.0 -1.5 -0.2 -0.4
Triglycerides 0.2 0.4 1.6 0.5 0.2 -0.3 0.9 0.3 0.3 1.0 0.6 1.1 0.2 0.9 0.2 0.1 0.4 1.3 0.6 -0.4 -0.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 3.7 -0.1 -1.5 0.8 -0.3 -0.6 -0.6 -0.1 1.5 -0.0 -0.8 -0.3 -0.7 1.9 -0.3 0.7 -0.3 -0.7 -0.4
Ulcerative Colitis 0.2 0.3 1.2 -0.5 0.1 -1.0 0.2 -0.5 -0.6 -0.1 0.6 -0.2 1.0 0.6 -0.1 -0.4 -0.3 1.1 0.5 0.1 0.2
Blood Eosinophil Count 1.8 14.2 43.3 -3.2 -5.7 2.6 -2.9 -4.1 -4.1 -3.0 -0.4 -3.0 -4.4 -3.1 -4.0 6.6 -3.8 -0.3 -3.3 -4.1 -4.0
Blood Platelet Count 0.3 3.9 29.7 3.3 0.9 -0.3 -0.3 0.8 1.3 2.6 5.5 0.8 2.0 1.5 0.2 -2.4 1.3 1.4 0.1 -0.5 1.6
Blood Red Count 0.5 4.8 9.3 0.6 3.0 -3.0 2.4 2.2 2.0 2.2 -0.4 2.0 2.4 2.7 2.6 -1.6 2.6 1.7 2.6 1.8 1.6
Blood White Count 0.3 2.2 6.6 2.6 0.9 0.3 1.3 1.5 1.9 2.4 1.7 1.7 1.2 1.9 0.9 -1.2 1.6 1.2 0.7 0.1 0.6
Heel T-Score 0.4 2.8 6.8 1.5 1.0 -0.5 2.6 1.5 1.6 1.6 1.0 2.3 1.4 1.8 1.4 -0.5 1.4 2.0 2.2 2.2 1.8
BMI 0.4 2.1 6.1 1.5 1.0 -2.3 1.4 0.7 0.8 2.4 2.4 1.6 0.3 1.4 0.5 -0.8 1.2 2.5 1.1 -0.1 0.4
Height 1.3 24.9 93.3 -4.3 -8.3 3.0 -3.1 -5.4 -5.4 -4.2 -0.8 -3.6 -6.2 -4.9 -5.2 9.7 -5.1 1.0 -3.5 -3.6 -4.3
Waist Hip Ratio (WHR) 0.6 2.9 10.2 0.7 2.9 -0.6 0.4 1.8 1.6 0.5 0.2 0.1 2.3 0.1 2.1 -3.2 1.6 -1.9 1.2 2.0 2.1
Systolic Blood Pressure 1.0 5.1 12.7 -3.4 -2.4 0.2 -2.2 -2.5 -2.7 -2.3 -0.4 -2.3 -2.3 -2.3 -2.2 3.6 -2.2 -0.2 -1.9 -2.2 -2.2
Smoking Status 2.6 6.3 12.6 -3.0 -0.9 0.5 -2.8 -2.6 -2.7 -3.1 -2.4 -3.5 -1.4 -3.1 -2.2 0.2 -2.7 -3.6 -2.9 -1.8 -2.3
Allergy or Eczema 1.3 3.4 5.7 -1.8 -1.7 1.0 -1.6 -1.9 -2.0 -2.4 -1.6 -2.0 -1.9 -1.8 -1.8 2.2 -2.1 -1.3 -1.8 -1.8 -2.3
Cardiovascular Disease 0.2 0.6 3.3 -1.8 0.4 -1.4 -0.7 -0.7 -0.9 -1.1 -0.5 -0.7 -0.5 -0.1 -0.3 0.6 -0.6 0.1 -0.4 -0.5 -0.9
Hypothyroidism (self reported) 1.3 2.9 7.6 0.5 2.4 -1.8 0.8 2.0 1.7 -0.3 -1.3 0.4 1.7 1.0 2.4 -2.0 1.6 -1.5 1.6 2.8 2.0
Respiratory disease 0.3 0.7 2.2 -1.3 -1.0 1.2 -0.9 -0.1 -0.2 -0.9 0.0 -0.9 -0.9 -0.2 -0.0 1.5 -0.1 -1.2 -0.6 -0.5 -0.4
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.1 -0.7 1.0 -1.1 -0.4 0.1 -0.0 -0.8 -0.9 -0.3 -0.6 0.1 0.5 -0.2 0.1 -1.0 -0.1 0.1 -0.4
Lung FEV1/FVC ratio 2.3 11.9 35.3 5.0 1.9 -2.0 3.0 2.9 3.2 4.4 5.9 3.0 3.7 3.6 2.2 -2.2 3.1 3.5 3.0 3.1 3.9
Lung FVC 0.4 1.9 17.5 -1.1 0.2 -1.2 -0.4 -0.6 -0.6 -1.0 -4.2 -0.6 -0.1 0.2 -0.4 -1.6 -0.7 -1.5 -1.0 -1.0 -1.8
Neuroticism 0.2 0.4 2.6 0.0 -0.6 -0.7 0.3 -0.7 -0.7 -0.0 1.0 0.2 -0.2 -0.0 -0.7 0.7 -0.7 1.6 0.3 0.4 -0.1
Chronotype (morning person) 2.2 5.0 21.4 -2.0 -0.4 1.2 -3.4 -1.2 -1.4 -3.5 -2.7 -3.2 -0.3 -2.9 -0.8 -1.0 -1.7 -4.6 -2.2 0.2 -0.1
Hair Pigment 0.3 7.4 11.4 -2.8 -2.6 1.8 -2.2 -2.9 -2.9 -2.9 -3.0 -2.1 -3.4 -2.8 -2.7 3.0 -3.1 -1.5 -2.7 -2.5 -3.3
Tanning 0.1 1.6 4.8 2.2 0.6 -1.9 1.6 1.1 1.2 1.5 0.1 1.8 0.5 2.2 0.8 -1.0 0.9 0.9 1.0 0.6 0.6
Hand grip strength (left) 4.0 10.7 25.7 -3.0 -4.5 3.2 -2.5 -3.1 -2.9 -3.0 -2.3 -2.3 -3.8 -3.0 -3.3 5.1 -3.2 -0.9 -3.2 -3.5 -3.8
Number of treatments/medications taken 0.4 0.8 5.8 -0.6 0.9 -2.4 1.5 0.6 0.4 0.2 -1.0 0.6 0.0 -0.2 0.9 0.4 0.6 0.5 1.0 0.6 -0.2
Average weekly spirits intake 0.4 0.4 2.3 -0.9 -0.5 1.0 0.0 0.0 -0.0 -0.7 -0.6 -0.2 -1.4 0.2 0.1 1.5 -0.2 -0.7 -0.1 0.2 -0.2
Sensitivity / hurt feelings 0.3 0.5 2.3 0.5 1.0 -1.5 0.5 0.4 0.5 0.2 0.4 0.3 0.9 0.7 0.3 -1.2 0.2 -0.1 0.4 1.3 0.8
Frequency of depressed mood in last 2 weeks 3.8 5.3 13.9 1.4 1.2 -1.5 3.4 1.9 1.9 2.8 1.5 3.5 1.2 3.7 1.9 0.5 2.2 3.5 2.9 1.4 1.4
Hearing difficulty/problems: Yes 1.0 1.5 5.6 0.7 1.9 -0.9 0.7 1.2 1.2 0.8 -0.1 0.5 2.1 1.0 1.2 -2.4 1.1 -0.4 0.9 1.1 1.2
Relative age of first facial hair 0.2 0.4 1.2 0.4 -0.0 -0.0 0.7 0.9 1.0 0.0 -1.1 0.6 -0.1 0.0 0.8 0.8 0.7 -0.5 0.4 0.2 -0.0
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.9 0.3 0.5 -0.8 0.6 0.3 0.3 0.4 0.9 0.0 0.4 -0.1 0.3 -0.4 0.4 0.2 0.5 0.7 0.6
Ever used hormone-replacement therapy (HRT) 0.4 0.4 2.2 0.3 -0.5 -1.2 1.0 -0.0 0.0 0.6 1.0 0.7 -0.2 0.5 0.0 0.8 0.1 1.5 0.6 0.2 0.0
Ever had hysterectomy (womb removed) 0.4 0.5 3.2 -0.3 -1.1 -0.1 0.8 -0.3 -0.1 0.2 0.7 0.5 -0.8 0.1 -0.5 1.8 -0.3 0.7 -0.1 -0.5 -0.7
Systolic blood pressure, automated reading 1.0 2.8 6.3 -2.5 -1.3 0.8 -1.8 -1.9 -2.1 -1.3 -0.3 -1.7 -1.7 -1.3 -1.6 2.2 -1.5 -0.1 -1.5 -2.3 -2.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.4 0.2 -0.2 -0.1 -0.3 -0.5 -0.5 -0.5 0.1 -0.6 -0.5 0.1 -0.5 0.3 -0.5 -0.6 -0.5 -0.2 -0.4
Angina 0.8 1.0 3.6 1.3 0.9 -1.2 0.7 1.3 1.4 0.8 -0.1 0.6 0.6 0.7 1.0 -1.9 1.1 -0.5 0.5 1.2 1.1
Medication for hormone replacement therapy 0.2 0.3 0.7 0.7 0.2 0.3 0.6 0.4 0.4 0.8 0.8 0.6 0.3 0.5 0.4 -0.1 0.6 0.7 0.6 0.0 0.3
Vitamin and mineral supplements 2.3 3.1 9.6 -0.9 -2.9 2.5 -1.4 -1.9 -1.8 -1.2 0.2 -1.1 -1.6 -2.4 -1.8 3.1 -1.7 0.5 -1.2 -1.4 -1.3
Supplements: Zinc 0.8 0.9 2.9 0.2 0.4 -0.7 1.7 0.8 0.8 1.2 0.1 1.7 -0.3 1.1 0.8 1.1 0.9 1.4 1.1 0.3 0.1
Medication: Co-codamol 0.6 0.7 3.1 0.3 -1.0 -1.7 0.6 -0.3 -0.1 0.3 0.0 0.5 -1.8 -0.5 -0.5 1.4 -0.2 0.3 -0.4 -1.0 -1.3
Medication: Metformin 0.6 0.8 4.5 -0.7 1.3 -0.7 -0.7 0.0 -0.2 -1.4 -1.3 -1.2 -0.0 0.1 0.4 -0.8 -0.2 -2.1 -0.2 0.8 0.2
Diabetes (father) 0.7 0.8 2.0 -1.4 0.2 0.3 -0.6 -1.1 -1.2 -1.2 -1.0 -1.1 -0.8 -1.3 -0.7 0.2 -1.0 -0.9 -0.7 -0.2 -0.9
Diabetes (mother) 0.4 0.6 2.6 -0.6 -1.1 0.8 0.3 -0.7 -0.8 -0.5 -0.5 -0.2 -1.4 -0.4 -0.6 1.6 -0.7 0.1 -0.2 -0.2 -0.7
Severe depression (siblings) 2.4 2.7 6.6 1.0 1.5 -1.7 2.6 1.5 1.4 1.8 0.2 2.1 1.7 0.6 1.6 -0.8 1.4 1.6 2.2 2.2 1.6
Pack years adult smoking proportion 0.3 0.4 2.3 0.2 0.9 -0.9 -0.5 -0.0 -0.0 -0.5 0.2 -0.9 0.8 -0.0 0.1 -1.5 -0.2 -1.0 -0.1 0.6 0.6
Impedance of leg (right) 0.1 0.4 2.9 -0.5 0.4 -0.5 0.5 0.1 -0.0 -0.8 -1.7 0.2 -0.2 0.1 0.3 0.5 -0.2 -1.1 0.1 0.4 -0.5
Leg fat-free mass (left) 0.1 0.8 4.6 0.2 -1.1 -0.9 0.3 -0.5 -0.5 0.6 1.8 0.1 -0.4 -0.8 -0.5 1.2 -0.1 2.1 0.5 0.1 0.4
Trunk fat percentage 0.8 3.3 7.3 1.7 1.8 -2.2 2.5 1.6 1.6 2.7 1.9 2.0 0.9 1.9 1.7 -1.0 2.1 2.0 2.0 1.1 1.2
Hand grip strength (right) 3.9 10.7 24.0 -2.4 -4.9 3.2 -3.1 -3.3 -3.0 -3.2 -1.4 -2.8 -3.4 -3.1 -3.6 4.6 -3.4 -1.3 -3.5 -3.3 -3.3
Townsend deprivation index at recruitment 1.8 2.6 5.7 -1.1 -1.9 0.3 -0.8 -1.6 -1.5 -1.5 -1.9 -0.7 -2.4 -0.9 -1.8 2.2 -1.9 -0.8 -1.7 -1.7 -2.3
Current tobacco smoking 0.3 0.4 3.2 0.7 0.7 -1.8 0.3 0.2 0.2 0.3 -0.6 -0.0 0.4 0.8 0.2 -1.2 0.1 -0.8 -0.1 0.1 -0.1
Average weekly fortified wine intake 0.3 0.4 2.2 0.5 -0.4 0.8 -0.8 0.1 0.2 -0.5 -0.5 -0.5 -1.1 0.1 -0.0 -0.2 0.0 -1.5 -0.9 -0.2 -0.3
Maternal smoking around birth 4.5 6.5 10.4 3.2 1.7 -2.6 3.1 2.7 2.8 2.7 1.9 3.0 2.3 2.3 2.5 -1.0 2.6 2.3 3.0 2.6 2.5
Fed-up feelings 2.7 4.9 13.1 1.7 0.8 -2.0 3.2 1.9 1.9 2.9 1.7 3.2 0.9 2.7 1.7 0.5 2.1 3.6 2.9 1.7 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 2.4 3.2 9.8 1.0 0.6 -0.9 3.1 1.4 1.5 2.5 1.0 2.9 1.0 2.2 1.3 0.5 1.6 3.1 2.3 0.8 0.8
Relative age voice broke 1.1 1.8 3.1 1.5 1.7 -0.5 0.8 1.7 1.7 1.2 0.2 1.3 1.3 1.8 1.7 -1.6 1.7 -0.0 1.2 0.9 1.2
Taking other prescription medications 0.5 0.7 3.2 -0.5 1.3 -1.8 1.0 0.6 0.4 0.2 0.1 0.6 0.9 -0.1 1.0 -0.1 0.7 0.6 1.2 1.0 0.7
Age when periods started (menarche) 0.3 0.6 1.9 0.5 0.9 0.6 -1.1 0.7 0.7 0.4 1.1 -0.4 1.4 0.1 0.7 -1.2 0.8 -1.1 -0.3 -0.3 0.4
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 2.4 0.3 -0.4 -1.0 0.7 -0.1 -0.1 0.8 1.6 0.3 -0.4 0.6 0.0 0.7 0.2 0.9 0.4 0.4 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.1 -0.6 -0.5 0.8 -0.1 -0.9 -0.8 -0.8 -0.6 -0.4 -0.6 -0.6 -0.8 0.6 -1.1 -0.4 -0.5 -0.3 -0.7
Tinnitus: Yes, but not now, but have in the past 4.1 4.4 9.5 2.2 1.6 -3.1 2.7 1.8 1.8 2.4 1.3 2.6 2.1 1.4 1.7 -1.0 1.9 2.7 2.4 2.0 1.7
Qualifications: CSEs or equivalent 0.4 0.6 2.1 0.5 1.3 -0.6 -0.4 0.5 0.6 0.4 1.5 -0.1 0.5 0.8 0.6 -1.5 0.7 -0.5 0.1 -0.1 0.7
Serious illness, injury or assault to yourself 0.3 0.3 1.2 0.1 -0.3 -1.1 0.8 -0.1 -0.0 0.6 0.9 0.4 -0.4 -0.0 -0.2 0.9 0.1 0.9 0.3 -0.3 -0.2
High blood pressure 0.1 0.4 2.3 -1.5 0.7 -0.1 -0.9 -0.4 -0.7 -1.0 -0.5 -0.8 0.2 -0.2 -0.1 -0.2 -0.4 -0.1 -0.2 -0.1 -0.3
Hayfever, allergic rhinitis or eczema 1.6 3.4 5.8 -2.0 -1.8 0.7 -1.5 -2.0 -2.1 -2.4 -1.5 -1.9 -2.0 -1.6 -1.8 2.4 -2.2 -1.1 -1.7 -1.7 -2.2
Multivitamins +/- minerals 2.6 3.3 7.4 1.7 2.4 -2.5 1.4 2.0 2.1 1.7 1.2 1.3 1.6 2.2 1.8 -2.7 2.0 -0.2 1.3 1.2 1.5
Stomach or abdominal pain in last month 0.8 1.1 4.5 0.2 0.6 -0.9 1.4 0.7 0.6 1.1 0.5 1.7 0.5 0.9 0.8 0.8 0.8 2.1 1.5 0.6 0.4
Supplements: Glucosamine 2.0 2.6 5.0 1.5 1.8 -0.4 1.2 1.9 1.9 1.0 0.3 1.1 1.6 1.8 2.0 -2.2 1.7 -0.3 1.6 2.1 2.2
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.6 0.1 0.6 -0.2 0.9 0.5 0.4 0.8 1.6 1.0 0.6 1.1 0.7 0.5 0.6 1.6 1.2 0.9 0.9
Medication: Atenolol 0.5 0.6 1.4 1.0 0.3 -0.9 0.9 1.0 1.1 0.7 -0.2 1.2 0.3 0.7 0.9 -0.2 0.9 0.9 0.9 0.7 0.6
Medication: Levothyroxine sodium 1.1 1.8 5.0 0.2 2.2 -0.9 0.4 1.3 1.0 0.3 0.2 -0.2 2.1 0.6 1.7 -2.2 1.3 -0.7 1.3 1.8 1.8
Sitting height 0.3 2.3 17.8 -1.2 -2.4 -0.2 0.6 -0.6 -0.9 -1.3 -2.1 0.4 -1.8 -1.4 -0.3 4.2 -0.7 1.6 0.5 0.3 -0.8
Chronic bronchitis/emphysema (father) 1.0 1.2 3.5 -1.1 -0.6 -0.0 -0.6 -1.0 -1.0 -0.8 -1.3 -1.2 -1.5 -1.9 -1.1 0.2 -0.9 -1.1 -1.3 -1.2 -1.5
High blood pressure (mother) 0.6 0.9 5.1 -0.0 -0.5 -0.5 0.7 0.3 0.3 0.7 1.6 0.9 0.2 0.6 0.4 1.9 0.6 2.3 1.0 -0.1 0.2
Body mass index (BMI) 0.6 2.8 9.2 1.7 1.0 -2.0 1.9 0.9 1.0 2.8 2.8 2.0 0.4 1.6 0.7 -0.5 1.5 3.0 1.4 0.0 0.5
Impedance of leg (left) 0.1 0.5 3.9 -0.8 0.6 -0.4 0.2 0.1 -0.1 -1.1 -2.0 -0.1 -0.2 0.2 0.3 0.1 -0.2 -1.5 -0.2 0.3 -0.6
Leg predicted mass (left) 0.2 0.8 4.9 0.2 -1.1 -1.0 0.3 -0.5 -0.5 0.7 1.8 0.1 -0.4 -0.8 -0.5 1.2 -0.1 2.2 0.5 0.1 0.4
Trunk fat mass 0.5 2.2 5.2 1.2 1.1 -2.2 2.0 1.0 0.9 2.2 1.9 1.6 0.4 1.3 1.1 -0.2 1.5 2.3 1.7 0.7 0.8
Waist circumference 0.8 2.9 7.1 1.3 2.1 -2.7 2.1 1.3 1.2 2.4 1.7 1.8 1.0 1.5 1.5 -1.1 1.8 2.1 1.9 1.0 1.0
Number of incorrect matches in round 0.6 1.0 8.0 -1.7 0.1 0.6 -0.5 -0.0 -0.2 -1.6 -2.8 -0.0 -0.7 0.6 0.3 0.8 -0.4 -1.1 -0.3 -0.0 -1.0
Past tobacco smoking 3.3 6.1 14.7 3.1 0.8 -0.5 2.6 2.2 2.5 3.7 2.9 3.4 1.2 3.5 1.8 -0.5 2.6 3.8 2.5 1.0 1.8
Alcohol usually taken with meals 0.2 0.2 1.1 -0.9 -0.5 0.9 -0.2 -0.2 -0.3 -0.6 0.0 0.1 -0.3 -0.6 -0.0 1.0 -0.3 0.6 0.3 0.1 0.2
Nervous feelings 0.8 1.6 4.5 -1.6 -1.4 0.1 -0.3 -1.4 -1.4 -1.1 -1.1 -0.8 -2.1 0.0 -1.4 2.0 -1.4 -0.0 -0.9 -1.0 -1.6
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 4.5 0.7 1.7 -1.4 1.9 1.4 1.2 1.6 1.3 1.8 1.8 1.8 1.5 -0.8 1.6 1.5 2.1 1.8 1.9
Hearing difficulty/problems with background noise 0.2 0.4 2.1 -0.1 0.3 1.3 -0.4 0.2 0.3 -0.6 -0.8 -0.5 0.5 0.1 0.1 -0.9 -0.1 -1.4 -0.4 0.6 0.3
Hair/balding pattern: Pattern 2 0.3 0.4 1.3 -0.4 0.8 -0.6 -0.2 -0.1 -0.2 -0.1 0.9 -0.3 1.0 0.8 0.2 -1.1 -0.0 0.5 0.6 0.6 1.1
Had menopause 0.1 0.2 1.4 -0.6 -0.2 0.5 -0.4 -0.2 -0.3 -0.2 1.2 -0.4 -0.0 -0.2 0.0 0.5 0.1 0.5 0.2 -0.1 0.4
Had other major operations 2.6 3.2 6.5 1.9 1.1 -0.8 1.7 2.0 1.9 1.6 2.1 1.5 2.0 0.6 2.2 -0.6 2.1 1.3 2.4 2.2 2.5
Forced vital capacity (FVC) 1.1 4.1 7.5 -2.1 -1.8 0.8 -2.4 -2.1 -2.1 -2.7 -2.6 -2.5 -1.5 -2.2 -1.9 0.7 -2.2 -2.0 -2.3 -1.3 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.7 -0.3 -0.2 0.8 -0.1 -0.5 -0.5 -0.7 -0.3 -0.2 -0.3 -0.6 -0.5 0.5 -0.8 -0.6 -0.3 0.0 -0.3
Ever unenthusiastic/disinterested for a whole week 1.7 2.0 12.0 1.7 -0.2 -3.5 1.9 0.5 0.8 1.7 1.6 1.8 0.3 1.0 0.1 0.5 0.6 2.2 1.0 0.6 0.4
Qualifications: None of the above 0.6 1.4 3.4 -1.0 -1.0 1.1 -0.7 -1.5 -1.5 -0.8 -0.6 -0.9 -1.3 -0.8 -1.5 0.6 -1.5 0.1 -1.2 -1.5 -1.8
Financial difficulties in last 2 years 0.5 0.7 6.6 0.0 0.5 -1.3 0.5 0.0 0.0 1.2 2.6 0.6 0.4 -0.2 -0.0 0.4 0.5 1.2 0.3 -0.3 0.1
Mouth/teeth dental problems 0.5 0.8 1.7 1.0 -0.1 0.3 1.1 0.8 0.9 1.1 1.2 1.3 -0.1 1.1 0.6 0.5 0.8 1.3 0.9 0.3 0.6
Heart attack 0.4 0.5 4.3 0.4 0.7 -2.1 0.8 0.3 0.2 0.3 -0.5 0.7 0.7 -0.5 0.3 -0.7 0.2 0.9 0.6 0.7 0.2
Allergy 0.6 1.3 3.0 1.7 1.1 -0.3 0.7 1.1 1.2 1.3 0.8 0.9 1.2 0.7 1.1 -1.7 1.3 0.5 1.0 1.5 1.6
Pain all over the body in last month 0.2 0.2 1.2 -0.1 0.2 -0.3 0.2 -0.5 -0.5 0.3 0.2 0.2 -0.2 -1.0 -0.5 -0.2 -0.5 1.1 0.0 -0.6 -0.5
Diabetes (self-reported) 0.2 0.3 1.2 -0.3 0.6 -0.9 -0.5 -0.1 -0.2 -0.9 -0.8 -0.4 -0.5 -0.2 0.1 -0.2 -0.2 -1.1 -0.3 0.2 -0.4
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 1.2 -0.7 0.4 -0.3 0.1 -0.1 -0.3 -0.5 -0.1 0.1 -0.4 0.6 0.2 1.1 -0.1 0.5 0.4 -0.1 -0.2
Medication: Ramipril 1.1 1.4 2.7 0.5 1.4 -1.6 1.0 1.4 1.4 1.0 0.6 1.2 1.4 1.4 1.4 -1.0 1.4 0.9 1.2 1.2 1.0
Medication: Simvastatin 0.1 0.2 1.1 -0.3 0.5 -1.0 0.1 0.1 0.0 -0.1 -0.7 -0.0 -0.3 -0.5 0.2 -0.5 0.1 0.1 0.0 -0.3 -0.6
Fluid intelligence score 1.0 2.1 4.8 1.7 1.0 -2.2 1.6 1.6 1.7 1.5 0.6 1.6 1.7 1.1 1.4 -0.9 1.5 1.1 1.5 1.4 1.6
Illnesses of siblings 0.6 0.8 3.4 0.4 -0.3 1.8 -1.5 -0.5 -0.4 -0.8 0.1 -1.3 0.3 -1.0 -0.6 -0.6 -0.6 -1.6 -1.0 -0.1 0.2
Neuroticism score 0.2 0.5 2.9 -0.1 -0.7 -0.6 0.6 -0.6 -0.6 0.1 0.9 0.5 -0.5 0.4 -0.6 1.2 -0.5 1.7 0.4 0.4 -0.0
Weight 0.3 1.5 9.0 0.7 -0.5 -1.9 1.4 -0.1 -0.1 1.6 2.0 1.1 -0.6 0.3 -0.1 1.4 0.5 3.0 1.0 -0.2 -0.0
Impedance of arm (right) 0.2 0.8 2.0 0.5 0.8 0.2 1.4 1.2 1.1 0.3 -0.9 0.9 0.5 0.7 1.4 0.0 0.9 -0.5 1.2 1.3 0.9
Arm fat percentage (right) 1.4 5.4 13.1 2.4 1.9 -2.3 3.0 1.8 1.9 3.6 2.9 2.9 1.0 2.4 1.7 -0.8 2.4 3.4 2.4 0.9 1.3
Trunk fat-free mass 0.3 1.6 6.6 -0.3 -2.2 -0.7 -0.1 -1.2 -1.2 0.0 1.5 -0.1 -1.1 -1.0 -1.2 2.5 -0.8 2.6 0.0 -0.5 -0.3
Hip circumference 0.4 1.8 9.9 0.4 -0.0 -1.8 1.7 0.2 0.1 2.0 2.0 1.5 -0.6 1.2 0.3 1.4 0.9 3.1 1.2 -0.4 -0.1
Time employed in main current job 0.7 0.8 2.5 -1.6 -0.3 -0.5 -0.4 -0.5 -0.5 -0.4 -1.3 -0.6 -1.4 -0.7 -0.5 0.7 -0.3 -0.7 -0.8 -1.5 -1.3
Alcohol intake versus 10 years previously 0.4 0.6 1.9 -1.1 0.0 -1.4 -0.7 -0.7 -0.8 -0.7 -0.2 -1.2 -0.3 -0.1 -0.5 -0.4 -0.6 -1.2 -0.9 -0.4 -0.8
Father’s age at death 1.7 2.2 3.6 -1.6 -1.5 1.5 -1.4 -1.9 -1.8 -1.8 -0.5 -1.9 -1.8 -1.6 -1.8 1.0 -1.9 -0.7 -1.4 -0.8 -1.0
Worrier / anxious feelings 0.1 0.2 1.2 -0.6 0.5 -0.1 -0.8 -0.3 -0.5 -0.1 0.5 -0.7 0.3 0.7 -0.1 -1.1 -0.1 -0.0 -0.1 0.2 0.5
Frequency of tiredness / lethargy in last 2 weeks 5.4 8.8 16.9 2.6 2.2 -2.4 3.5 2.8 2.7 3.8 2.7 4.0 2.1 3.6 2.8 -0.7 3.2 4.1 3.7 1.9 2.4
Falls in the last year 1.3 1.8 4.5 1.8 1.3 -1.6 1.9 1.1 1.2 2.1 1.3 1.6 0.8 0.5 0.8 -1.1 1.2 1.4 1.3 0.9 1.0
Hair/balding pattern: Pattern 3 1.3 1.9 4.5 1.8 1.4 -0.3 0.9 2.0 2.1 1.1 0.3 1.0 1.6 0.5 1.6 -1.6 1.7 -0.7 0.9 1.7 1.5
Number of live births 2.5 3.6 9.9 2.0 1.9 -0.1 1.6 1.7 1.6 2.0 3.1 1.6 2.1 1.7 1.7 -1.1 1.7 1.9 2.2 2.0 2.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.3 -0.5 -0.8 -0.4 -1.1 -1.0 -0.9 -1.1 -0.6 -1.1 -0.2 -1.0 -1.0 -0.0 -1.1 -0.6 -1.1 -0.3 -0.7
Pulse rate 0.7 1.2 5.2 -2.3 0.6 -0.6 -1.2 -1.2 -1.4 -1.0 -1.1 -1.3 -0.1 -1.3 -0.8 -1.0 -0.9 -0.6 -0.8 -0.9 -1.0
Happiness 0.8 0.9 5.5 -0.3 -1.0 1.3 0.6 0.2 0.2 0.7 1.2 1.1 -0.6 0.7 0.1 2.4 0.2 1.8 0.7 -0.2 0.3
Noisy workplace 0.6 0.7 1.9 1.4 0.9 -0.4 0.6 1.2 1.2 0.4 -0.5 0.4 1.0 0.2 1.1 -1.0 1.1 -0.7 0.4 0.9 0.5
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.7 1.4 0.2 0.0 1.3 1.5 1.6 0.9 0.8 1.3 1.3 0.5 1.5 0.1 1.3 0.6 1.6 1.6 1.9
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 2.3 0.3 -0.6 0.1 0.2 0.1 0.2 0.3 1.5 -0.1 -0.4 0.3 -0.1 0.8 0.3 0.4 0.0 0.1 0.2
Mouth/teeth dental problems: Dentures 0.1 0.2 1.3 0.6 -0.2 -1.1 0.7 0.1 0.2 0.2 -0.6 0.2 0.4 -0.0 0.1 -0.0 0.1 -0.0 0.2 0.2 -0.1
Asthma 0.1 0.3 1.1 -0.8 -0.5 1.1 -0.7 0.1 -0.0 -0.7 0.3 -1.0 0.1 -0.0 0.1 0.4 0.1 -0.9 -0.2 0.1 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.3 1.2 0.7 -0.8 1.2 0.7 0.8 0.8 0.8 0.9 1.5 -0.2 0.7 -1.0 0.6 1.2 1.1 1.2 1.1
Medication: Cholesterol lowering 0.3 0.4 1.7 -0.6 0.1 -1.3 -0.6 -0.6 -0.7 -0.9 -0.8 -0.7 -0.3 -1.0 -0.4 -0.3 -0.6 -0.3 -0.5 -0.3 -0.6
Depression (self-reported) 0.2 0.2 1.5 -0.2 0.4 -1.2 0.5 -0.2 -0.3 -0.3 -0.8 0.1 -0.7 -0.3 -0.1 0.0 -0.3 -0.3 0.2 0.8 0.0
Medication: Lansoprazole 1.0 1.1 3.0 0.7 1.4 -1.7 1.5 0.8 0.7 0.9 -0.3 1.2 0.8 1.2 1.1 -0.8 0.8 0.8 1.4 1.0 0.6
Prospective memory result 0.7 0.8 2.3 0.9 0.9 0.7 0.6 1.2 1.2 0.7 0.1 0.5 0.4 1.1 1.1 -1.5 1.0 -0.4 0.6 1.3 1.1
Lung cancer (father) 0.9 1.0 4.3 1.2 -0.1 -1.8 1.0 0.2 0.4 1.2 2.1 1.1 1.1 0.1 -0.1 -0.3 0.2 1.9 0.7 0.3 0.4
Illnesses of mother 0.5 0.7 3.4 1.5 0.8 0.2 0.6 0.8 0.9 0.8 0.1 0.4 0.8 0.4 0.4 -1.8 0.6 -0.5 0.2 0.9 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.6 0.0 -0.8 -0.4 -0.3 -0.6 -0.5 -0.7 -0.7 -0.4 -0.5 -0.1 -0.7 0.5 -0.8 -0.0 -0.6 0.1 -0.4
Pulse wave Arterial Stiffness index 0.4 0.4 1.7 -0.7 1.3 -0.9 0.0 0.3 0.2 -0.4 -0.7 -0.4 0.8 0.1 0.5 -1.1 0.2 -0.8 0.2 0.8 0.4
Impedance of arm (left) 0.2 1.0 2.4 0.4 1.1 0.4 1.1 1.3 1.1 -0.1 -1.5 0.7 0.7 0.6 1.6 -0.4 0.9 -1.1 1.1 1.5 0.9
Arm fat mass (right) 0.8 3.5 11.3 2.0 0.9 -2.2 2.4 1.1 1.2 3.0 2.8 2.2 0.4 1.7 1.0 -0.1 1.7 3.4 1.9 0.5 0.9
Trunk predicted mass 0.3 1.6 7.0 -0.3 -2.3 -0.8 -0.0 -1.1 -1.1 0.1 1.6 -0.0 -1.1 -1.0 -1.1 2.6 -0.8 2.6 0.1 -0.5 -0.3
Standing height 0.5 4.9 18.9 -2.3 -3.5 0.2 -1.2 -2.3 -2.5 -2.6 -1.3 -1.8 -2.4 -3.0 -1.9 4.3 -2.3 0.2 -1.0 -0.6 -1.4
Length of working week for main job 2.0 2.2 3.6 1.6 1.3 -1.1 1.2 1.8 1.9 1.8 1.5 1.7 1.6 0.8 1.8 -1.3 1.9 1.0 1.5 1.0 1.5
Exposure to tobacco smoke at home 0.4 0.4 1.1 -0.8 0.4 -0.2 -1.0 -0.7 -0.7 -0.7 0.0 -0.8 -0.4 -0.6 -0.6 -0.3 -0.5 -0.4 -0.8 -0.8 -0.7
Breastfed as a baby 0.2 0.2 1.3 0.6 -0.6 1.1 -0.2 -0.0 0.1 0.2 0.2 0.2 -0.8 -0.7 -0.3 0.4 0.0 0.0 -0.3 -0.4 -0.1
Tense / ‘highly strung’ 0.6 1.0 2.4 -1.3 -1.1 0.7 -0.3 -1.1 -1.2 -1.6 -1.3 -0.9 -1.2 -0.5 -1.1 1.0 -1.4 -0.6 -0.6 0.1 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 6.1 0.6 -0.6 -2.5 0.8 -0.3 -0.1 0.1 -0.0 0.6 0.1 -0.6 -0.6 0.4 -0.5 1.0 0.1 0.4 -0.1
Hair/balding pattern: Pattern 4 0.1 0.2 1.1 -0.2 0.2 -1.1 0.2 -0.0 -0.1 -0.3 -0.3 -0.3 0.3 -0.3 0.2 -0.5 -0.1 -0.2 0.3 0.8 0.5
Birth weight of first child 1.1 2.0 11.6 0.0 -2.8 1.6 0.3 -0.9 -0.6 0.4 1.6 0.0 -1.8 0.4 -1.4 3.4 -0.6 1.0 -0.8 -1.5 -1.1
Peak expiratory flow (PEF) 1.1 2.5 5.9 -1.8 -1.0 0.4 -1.8 -1.4 -1.5 -2.4 -1.5 -2.0 -1.3 -2.1 -1.3 1.0 -1.7 -2.0 -1.8 -0.6 -1.3
Pulse wave reflection index 1.9 2.4 6.0 1.5 2.4 -1.6 1.9 1.7 1.7 1.4 -0.5 1.4 1.4 1.4 1.6 -2.0 1.4 0.1 1.4 1.6 1.2
Ever highly irritable/argumentative for 2 days 1.2 1.5 6.1 1.4 0.0 -0.4 1.2 0.7 0.7 2.0 2.0 1.8 0.2 0.6 0.7 1.0 1.1 2.5 1.2 0.1 0.4
Loud music exposure frequency 0.9 0.9 1.8 -1.0 -0.4 0.0 -1.2 -1.2 -1.2 -1.0 0.5 -1.3 -0.8 -1.1 -1.3 0.2 -1.2 -0.8 -1.3 -0.8 -0.7
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 2.7 1.0 0.3 -0.9 0.7 1.0 1.0 0.2 0.0 0.2 0.9 -0.2 0.9 -0.6 0.7 -0.5 0.8 1.6 1.5
Mouth/teeth dental problems: Bleeding gums 1.7 2.3 5.4 -1.7 -0.2 1.2 -2.3 -1.5 -1.6 -2.1 -1.6 -2.3 -0.9 -0.9 -1.1 -0.4 -1.5 -2.1 -1.7 -0.5 -0.9
Blood clot in the leg (DVT) 3.3 4.3 11.6 1.2 2.7 -3.4 2.4 2.0 2.0 1.8 -0.3 2.3 2.3 2.3 1.8 -2.7 1.7 1.2 2.0 1.7 1.4
Medication: Paracetamol 0.2 0.3 2.5 -0.4 -0.4 -1.6 -0.3 -0.4 -0.3 -0.1 -0.1 -0.5 0.2 -0.9 -0.5 0.3 -0.3 -0.3 -0.6 -0.6 -0.6
Headache pain in last month 1.1 1.9 4.3 1.0 0.5 -1.7 1.9 1.4 1.3 1.4 0.3 1.8 1.4 2.1 1.4 0.4 1.5 1.6 1.7 1.3 1.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.0 1.4 -0.1 0.2 0.9 0.7 0.8 1.1 1.0 0.8 0.6 1.2 0.4 -0.4 0.6 0.3 0.6 0.6 0.9
Glaucoma (self-reported) 0.6 0.8 4.0 -0.3 -1.2 2.0 -0.6 -0.8 -0.8 0.1 1.7 -0.4 -0.4 -0.5 -0.9 0.9 -0.5 0.9 -0.3 -0.4 -0.1
Gout (self-reported) 0.3 0.4 2.8 0.1 0.3 -0.4 -0.2 0.1 0.2 -0.6 -1.7 -0.2 -0.8 -0.2 -0.0 -0.9 -0.2 -1.4 -0.7 -0.1 -0.6
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 3.4 0.2 1.8 -1.0 0.5 1.3 1.1 -0.0 -0.0 -0.0 1.6 0.6 1.6 -1.4 1.2 -1.0 1.1 1.8 1.6
Medication: Amlodipine 0.6 0.8 3.1 0.7 0.7 0.6 -0.1 0.9 0.8 0.5 1.8 -0.1 1.2 0.9 0.9 -1.1 1.0 -0.2 0.6 1.0 1.5
Medication: Ventolin 100micrograms inhaler 1.7 2.2 4.5 -0.9 -2.1 1.4 -2.0 -1.4 -1.3 -1.4 0.6 -2.0 -1.2 -1.3 -1.6 1.6 -1.3 -1.3 -1.9 -1.3 -1.1
Birth weight 0.5 1.1 3.3 0.5 -1.5 1.8 -1.4 -0.1 -0.1 -1.0 0.6 -1.6 0.4 -1.6 -0.2 0.3 -0.2 -1.8 -0.8 0.8 0.9
Chronic bronchitis/emphysema (mother) 0.4 0.5 3.6 0.2 0.8 -1.9 1.1 0.4 0.4 0.8 -0.2 0.8 0.1 0.3 0.5 -0.1 0.6 0.3 0.4 -0.4 -0.8
High blood pressure (siblings) 1.0 1.5 7.6 -0.2 -1.2 -1.2 1.4 0.1 0.1 1.0 1.1 1.3 -1.3 0.0 0.1 2.8 0.4 2.5 0.8 -0.6 -0.6
Forced vital capacity (FVC), Best measure 0.6 2.0 6.4 -1.4 -1.5 0.4 -1.1 -1.4 -1.4 -1.9 -2.5 -1.3 -1.5 -1.0 -1.3 1.4 -1.6 -1.0 -1.3 -0.7 -1.5
Body fat percentage 0.9 3.5 7.8 1.8 2.0 -2.4 2.5 1.5 1.5 2.8 2.0 2.2 0.9 1.9 1.6 -1.1 2.0 2.2 2.0 1.0 1.0
Leg fat percentage (right) 0.7 2.6 7.5 1.4 1.4 -2.7 2.2 0.9 1.0 2.5 1.9 2.1 0.4 1.7 0.8 -0.5 1.4 2.5 1.4 0.3 0.3
Arm fat-free mass (right) 0.2 1.0 3.2 -0.6 -1.5 -0.6 -0.6 -1.1 -1.2 -0.1 1.4 -0.5 -1.0 -1.0 -1.0 1.6 -0.7 1.8 -0.2 -0.7 -0.4
Exposure to tobacco smoke outside home 0.2 0.3 1.5 -0.1 1.2 0.6 -0.4 -0.1 -0.2 0.5 1.1 -0.4 0.1 -0.4 -0.0 -1.2 0.3 -0.4 -0.2 -0.5 0.1
Comparative body size at age 10 2.4 6.6 19.0 2.4 2.9 -4.4 2.3 2.8 2.7 2.2 0.6 2.3 2.5 2.9 2.7 -2.8 2.6 1.0 2.5 2.6 2.4
Number of full brothers 3.2 4.1 8.6 2.5 1.2 -1.6 2.2 2.3 2.4 2.4 1.5 2.3 1.3 2.9 2.2 -1.1 2.4 1.3 2.1 1.5 1.8
Worry too long after embarrassment 0.6 1.0 2.3 -0.8 -1.0 0.2 -0.9 -1.5 -1.5 -0.8 0.6 -0.9 -0.9 -0.1 -1.5 1.0 -1.3 -0.0 -1.0 -1.1 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.4 0.3 -0.4 -0.4 -0.0 -0.2 -0.1 -0.5 0.2 -0.3 0.2 -0.6 -0.3 -0.3 -0.5 -0.7 -0.1 0.6 0.5
Wheeze or whistling in the chest in last year 1.0 1.7 5.4 1.7 1.1 -2.3 1.5 1.5 1.6 1.1 0.3 1.4 1.4 1.0 1.3 -0.8 1.3 0.4 1.2 1.3 1.0
Number of children fathered 1.5 1.7 7.5 -0.7 -0.9 2.7 -1.6 -1.4 -1.4 -0.8 1.3 -1.4 -1.0 -1.6 -1.2 1.1 -1.0 -0.3 -1.3 -1.3 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 3.3 -0.9 -0.6 0.2 -0.9 -0.9 -0.9 -1.5 -1.8 -1.1 -1.1 -0.5 -0.8 0.1 -1.0 -1.5 -1.1 -0.6 -1.1
Age at first live birth 0.1 0.2 0.9 0.9 -0.1 0.4 -0.3 0.7 0.8 0.2 -0.1 0.2 0.6 0.4 0.5 -0.4 0.6 -0.4 -0.1 0.1 0.3
Pulse wave peak to peak time 0.5 0.6 2.8 0.6 -1.7 1.0 0.1 -0.4 -0.4 0.3 0.7 0.4 -1.2 -0.2 -0.6 1.6 -0.3 0.9 -0.2 -0.8 -0.5
Health satisfaction 1.4 1.8 4.4 1.1 1.2 -0.3 1.0 1.2 1.1 1.8 2.1 1.6 0.9 1.5 1.3 -0.4 1.6 2.0 1.6 0.7 1.3
Shortness of breath walking on level ground 1.4 1.7 3.8 1.9 1.5 -1.5 1.2 1.3 1.5 1.6 1.0 1.2 1.1 1.5 0.9 -1.9 1.3 0.3 0.7 0.8 0.8
Qualifications: College or University degree 0.3 0.9 2.6 0.4 0.2 0.9 0.5 1.1 1.0 0.7 1.0 0.9 0.8 0.7 1.2 0.5 1.2 0.9 1.3 1.0 1.6
Eye problems/disorders: None of the above 0.4 0.5 2.3 -0.6 1.5 -0.1 -0.5 0.2 0.0 -0.2 -0.9 -0.3 0.6 0.2 0.5 -1.5 0.2 -1.3 -0.1 0.1 0.2
Mouth/teeth dental problems: Loose teeth 1.9 2.3 5.2 2.3 0.9 -0.1 1.1 1.5 1.5 1.8 2.2 1.2 1.3 1.2 1.4 -1.2 1.6 1.4 1.6 1.4 2.0
Emphysema/chronic bronchitis 0.2 0.2 0.5 0.3 0.7 -0.3 0.6 0.5 0.5 0.6 0.1 0.5 0.0 -0.3 0.7 0.1 0.6 0.1 0.5 0.5 0.3
Medication for pain relief, constipation, heartburn 0.6 1.1 5.8 -0.4 -0.5 2.4 -1.4 -0.4 -0.6 -1.4 -1.2 -0.9 -0.8 -0.2 -0.3 0.3 -0.7 -1.9 -0.9 -0.1 -0.3
Neck or shoulder pain in last month 0.2 0.3 1.6 0.4 0.6 -0.5 0.7 0.5 0.5 0.0 -0.9 0.1 0.5 -0.0 0.5 -0.8 0.4 -0.5 0.4 1.3 0.6
Medication: Blood pressure 0.2 0.3 1.4 -0.8 0.1 0.6 -1.2 -0.3 -0.4 -0.9 0.1 -1.0 0.4 -0.9 -0.1 -0.1 -0.2 -0.5 -0.4 -0.1 -0.0
Angina (self-reported) 1.1 1.4 5.2 1.4 1.1 -1.3 0.8 1.4 1.6 0.8 -0.2 0.6 0.9 0.7 1.2 -2.3 1.2 -0.7 0.6 1.4 1.3
Migraine (self-reported) 1.0 1.3 5.9 -0.0 -2.4 1.1 -0.3 -1.1 -0.9 -0.8 -0.1 -0.7 -1.5 -1.2 -1.4 1.8 -1.1 -0.1 -1.0 -0.8 -1.0
Medication: Ibuprofen 0.9 1.1 2.3 1.4 1.0 -0.7 0.8 0.9 1.0 0.8 1.3 0.6 1.5 -0.1 0.8 -1.4 0.8 0.8 1.1 1.2 1.4
Medication: Allopurinol 0.2 0.3 0.8 0.9 0.3 -0.1 0.6 0.7 0.9 0.5 0.3 0.6 0.1 0.5 0.5 -0.5 0.6 -0.1 0.3 0.2 0.2
Medication: Omeprazole 0.6 0.7 3.7 -0.6 1.0 -1.9 1.2 0.3 0.2 1.1 0.9 0.6 0.3 0.2 0.5 -0.5 0.7 1.3 0.9 -0.0 0.1
Medication: Seretide 50 evohaler 0.9 1.0 3.2 -0.2 -1.5 0.9 -1.3 -0.4 -0.2 -0.7 0.3 -1.2 -1.1 -0.4 -0.8 0.6 -0.5 -1.8 -1.7 -1.2 -0.8
Mean time to correctly identify matches 1.1 2.0 5.0 0.5 2.2 -2.0 1.7 0.9 0.8 1.8 1.1 1.4 0.8 1.5 1.1 -1.4 1.2 2.2 1.7 1.0 0.8
Heart disease (mother) 0.2 0.2 0.9 0.6 -0.2 -0.6 0.1 0.8 0.9 0.1 -0.4 0.6 0.3 0.0 0.7 -0.1 0.7 -0.1 0.1 0.2 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.4 2.8 5.4 -1.6 -1.2 1.0 -2.1 -1.6 -1.6 -2.0 -1.4 -1.8 -1.7 -1.2 -1.5 0.3 -1.6 -1.8 -2.1 -2.3 -2.2
Whole body fat mass 0.4 1.7 5.2 1.1 0.9 -2.0 1.7 0.6 0.6 2.0 2.0 1.4 0.2 1.0 0.7 -0.2 1.1 2.3 1.3 0.5 0.5
Leg fat mass (right) 0.5 1.9 7.2 1.1 0.9 -2.7 1.8 0.6 0.6 2.1 2.0 1.6 0.2 1.0 0.6 -0.2 1.1 2.5 1.2 0.3 0.4
Arm predicted mass (right) 0.2 0.8 3.1 -0.4 -1.4 -0.9 -0.4 -1.0 -1.0 -0.0 1.3 -0.4 -0.8 -0.9 -0.9 1.3 -0.6 1.8 -0.1 -0.5 -0.3
Pulse rate, automated reading 0.4 1.2 3.0 -1.6 0.7 -0.5 -1.4 -0.8 -1.1 -1.2 -1.7 -1.3 -0.1 -1.7 -0.3 -0.9 -0.6 -1.5 -0.9 -0.7 -0.9
Alcohol intake frequency. 0.1 0.2 1.0 0.4 -0.7 0.2 0.5 0.1 0.1 0.4 0.0 0.2 -1.0 0.8 0.1 0.7 0.4 0.3 0.1 -0.3 -0.5
Comparative height size at age 10 1.0 5.6 20.9 -2.8 -3.5 0.7 -1.2 -2.2 -2.4 -2.7 -2.2 -1.9 -2.9 -2.7 -1.7 4.6 -2.2 -0.4 -1.4 -1.3 -2.1
Number of full sisters 1.5 1.8 7.3 0.2 1.8 -2.7 1.9 1.4 1.4 1.2 -0.9 1.7 1.1 0.7 1.3 -0.9 1.2 0.9 1.3 0.8 0.4
Suffer from ‘nerves’ 0.3 0.4 1.6 -0.2 -0.6 -1.2 0.4 -0.8 -0.8 -0.5 -0.6 0.1 -0.6 0.4 -0.9 0.8 -1.0 0.4 -0.3 0.0 -0.8
Overall health rating 0.5 1.1 8.0 0.1 1.5 -2.8 1.2 0.4 0.3 0.9 0.3 1.0 0.6 0.5 0.7 -0.9 0.7 1.4 1.1 0.8 0.3
Chest pain or discomfort 5.1 7.3 13.0 3.2 1.5 -2.9 3.2 2.8 3.0 3.6 2.9 3.0 2.5 2.6 2.2 -1.5 2.9 2.8 2.8 1.9 2.4
Had major operations 0.3 0.3 1.3 0.5 -0.1 -0.0 -0.3 0.4 0.5 -0.6 -0.5 -0.6 0.9 -0.5 0.3 -0.3 0.1 -1.2 -0.1 1.2 0.6
Age at last live birth 0.3 0.4 1.0 0.7 0.7 0.4 0.0 0.8 0.8 0.3 0.0 0.3 0.8 1.0 0.7 -0.5 0.7 -0.2 0.3 0.5 0.7
Family relationship satisfaction 0.9 1.1 3.9 1.3 -1.2 0.2 1.2 0.5 0.8 1.4 1.4 1.5 -0.4 0.8 0.1 2.0 0.5 1.7 0.5 -0.0 0.1
Leg pain on walking 1.8 2.2 4.8 0.9 1.4 -1.9 1.8 1.4 1.5 1.6 1.3 1.4 1.4 2.2 1.4 -1.1 1.4 1.2 1.6 1.5 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.5 3.2 -0.7 0.7 -0.6 -0.4 -0.2 -0.2 -0.8 -1.8 -0.5 -0.1 -0.2 -0.1 -0.7 -0.4 -1.5 -0.6 -0.5 -0.8
Commuting to job workplace: Car/motor vehicle 0.2 0.2 1.6 0.5 -0.3 0.7 0.3 0.1 0.2 0.5 1.3 -0.0 -0.6 -0.5 -0.2 0.2 0.1 0.3 -0.1 -0.4 -0.2
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 3.3 -0.2 -0.9 1.0 -0.2 -0.5 -0.5 -0.4 -1.8 0.3 -0.7 -0.2 -0.4 0.9 -0.5 0.4 -0.2 -0.4 -0.6
Medication: Aspirin 0.3 0.3 2.4 0.0 0.6 -1.5 0.8 0.3 0.4 0.3 -0.8 0.7 -0.4 0.1 0.3 -0.4 0.3 0.6 0.3 0.1 -0.5
Supplements: Vitamin C 2.2 2.6 6.7 0.8 2.1 -0.5 1.2 1.9 1.8 1.4 0.3 1.0 2.0 2.6 2.1 -2.2 2.0 0.4 1.6 1.4 1.6
Knee pain experienced in last month 0.3 0.4 1.0 -0.7 -0.1 -0.2 -0.1 -0.7 -0.7 -0.5 -0.6 -0.6 -0.8 -0.4 -0.6 0.1 -0.7 -0.9 -0.7 -0.6 -1.0
Hypertension (Self-reported) 0.2 0.6 3.4 -1.8 0.3 -0.1 -1.1 -0.8 -1.0 -1.1 -0.4 -0.9 -0.2 -0.4 -0.4 0.5 -0.6 0.1 -0.5 -0.7 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 1.9 7.5 -0.2 1.4 -2.7 2.1 0.9 0.7 1.5 0.7 1.6 0.8 1.6 1.2 -0.0 1.2 2.1 1.9 0.7 0.5
Illnesses of father: Heart disease 0.1 0.2 0.9 -0.8 0.4 0.2 -0.2 0.1 0.1 0.3 0.5 -0.3 -1.0 0.7 0.2 0.2 0.3 -0.1 -0.1 -0.5 -0.3
Illnesses of siblings: Diabetes 1.1 1.4 3.4 -1.4 -1.4 -0.9 -0.4 -1.1 -1.1 -1.1 -0.4 -0.6 -1.3 -1.1 -1.2 1.8 -1.3 -0.2 -1.0 -1.6 -1.8
Smoking status: Previous 7.4 11.1 20.3 -4.4 -1.9 1.6 -3.5 -3.2 -3.4 -4.5 -3.3 -4.1 -2.6 -4.5 -2.8 1.6 -3.5 -4.0 -3.5 -2.2 -3.0
Forced expiratory volume in 1-second (FEV1), predicted 0.5 0.9 2.9 -0.8 -1.4 0.0 -0.8 -0.7 -0.7 -1.2 -0.7 -1.0 -1.4 -1.2 -0.7 1.7 -0.9 -0.8 -0.8 -0.3 -0.6
Whole body fat-free mass 0.2 1.1 5.4 -0.2 -1.7 -0.9 -0.0 -1.0 -1.0 0.2 1.6 -0.2 -0.8 -1.0 -0.9 1.9 -0.6 2.3 0.1 -0.3 -0.1
Leg fat-free mass (right) 0.1 0.7 3.6 -0.0 -1.3 -0.7 0.0 -0.7 -0.7 0.4 1.5 -0.2 -0.6 -0.9 -0.6 1.3 -0.3 1.9 0.2 -0.1 0.2
Arm fat percentage (left) 1.5 5.9 13.2 2.5 2.2 -2.5 3.0 2.1 2.1 3.6 2.7 2.9 1.3 2.6 2.0 -1.2 2.6 3.2 2.6 1.2 1.5
Average weekly red wine intake 0.7 1.1 5.9 -0.5 -1.7 2.1 -0.8 -0.6 -0.7 -0.7 0.8 -0.8 -1.1 -1.1 -0.6 2.4 -0.5 0.1 -0.3 -0.1 0.1
Handedness (chirality/laterality): Left-handed 0.8 0.9 4.6 0.2 -1.5 -0.4 1.1 -0.4 -0.1 1.0 0.7 0.9 -0.9 0.1 -0.7 2.1 -0.3 1.8 0.0 -1.0 -0.9
Mood swings 0.3 0.5 2.8 -0.9 -0.4 0.2 0.0 -0.6 -0.7 -0.0 0.9 0.1 -0.5 -0.4 -0.4 1.7 -0.3 1.5 0.2 -0.1 -0.4
Loneliness, isolation 1.3 1.8 5.6 0.7 0.9 -2.1 2.1 0.6 0.5 1.7 0.7 1.8 0.6 2.0 0.7 -0.3 0.9 2.4 1.7 0.7 0.5
Long-standing illness, disability or infirmity 0.4 0.6 4.8 0.4 0.3 -2.2 1.5 0.4 0.4 0.4 -0.1 0.5 0.4 -0.5 0.3 0.1 0.2 0.7 0.8 1.0 0.2
Ever had bowel cancer screening 1.4 1.6 6.0 1.4 0.5 0.0 1.6 1.6 1.8 1.4 0.2 1.6 0.3 2.4 1.2 -0.3 1.3 0.6 1.2 1.0 1.0
Diabetes diagnosed by doctor 0.2 0.3 1.7 -0.1 0.9 -1.3 0.3 0.4 0.4 -0.3 -0.8 0.3 -0.3 0.5 0.7 -0.1 0.5 -0.5 0.3 0.6 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.8 0.9 1.1 -1.2 1.5 1.2 1.1 1.7 0.5 1.9 0.7 2.2 1.2 0.0 1.3 1.5 1.5 0.6 0.8
Friendships satisfaction 1.2 1.5 8.0 0.5 -1.1 -0.5 1.7 0.0 0.2 1.1 1.0 2.1 -0.6 0.5 -0.2 2.5 0.1 2.8 0.9 -0.1 -0.4
Qualifications: nursing, teaching 0.7 1.1 3.5 1.0 -0.9 -0.7 1.8 0.4 0.6 1.2 1.3 1.6 -0.4 0.8 0.1 1.9 0.4 1.6 0.8 0.2 0.3
Commuting to job workplace: Walk 0.4 0.5 1.8 -1.0 0.2 -1.3 -0.8 -0.5 -0.7 -1.1 -0.9 -0.7 0.3 -0.1 -0.1 -0.5 -0.5 -0.7 -0.1 0.7 0.2
Eye problems/disorders: Cataract 0.6 0.7 2.3 0.7 -0.8 -0.7 0.8 0.7 0.9 1.0 1.4 0.9 0.2 0.8 0.4 1.2 0.8 1.5 0.6 -0.2 0.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.6 -0.3 0.2 1.1 -0.4 -0.0 -0.2 -0.4 -0.2 -0.2 1.3 -0.3 0.3 -0.2 -0.1 -0.2 0.3 1.0 0.8
Medication for cholesterol 0.7 1.0 4.1 0.9 0.8 0.8 -0.1 0.7 0.7 -0.2 0.4 -0.3 1.9 -0.1 0.7 -1.5 0.4 -0.8 0.6 1.9 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.3 0.6 0.6 -0.6 0.8 0.3 0.3 0.7 0.4 0.5 0.7 0.5 0.4 -0.1 0.3 1.1 0.8 0.4 0.6
Back pain experienced in last month 0.4 0.5 3.1 0.1 1.5 -0.3 -0.0 0.4 0.2 0.3 0.5 -0.3 1.2 0.4 0.5 -1.8 0.5 -0.6 0.3 0.5 0.7
Mineral and other dietary supplements 0.4 0.5 4.1 -0.5 -1.3 0.8 -0.2 -0.5 -0.5 -0.2 0.2 -0.4 -0.4 -0.5 -0.5 2.0 -0.5 0.7 -0.1 -0.4 -0.2
Breast cancer (self-reported) 1.4 1.7 7.8 -0.7 -0.8 2.8 -2.3 -0.5 -0.5 -1.5 0.3 -2.1 -0.4 -1.1 -0.4 0.2 -0.6 -2.2 -1.3 -0.5 0.1
Asthma (self-reported) 0.1 0.3 1.3 -0.7 -0.7 1.1 -0.6 0.1 0.1 -0.6 0.4 -0.8 -0.1 0.1 0.2 0.7 0.2 -0.7 -0.2 0.0 0.3
Osteoporosis (self-reported) 1.1 1.3 3.5 -1.9 -0.2 -0.9 -1.1 -0.9 -1.0 -1.7 -1.8 -1.0 -0.2 -1.5 -0.7 0.5 -1.2 -1.6 -1.0 -0.6 -1.0
Osteoarthritis (self-reported) 0.2 0.3 1.9 -0.1 0.4 0.1 -0.2 -0.3 -0.4 -0.1 1.0 -0.4 1.1 -1.4 -0.2 -0.7 -0.2 0.1 0.1 0.5 0.5
Medication: Aspirin 0.3 0.4 2.5 0.3 0.7 -1.6 0.9 0.6 0.6 0.4 -0.4 0.8 0.1 0.1 0.6 -0.3 0.5 0.9 0.7 0.5 0.0
Medication: Gliclazide 0.1 0.2 0.5 -0.1 0.6 -0.5 0.5 0.4 0.3 0.0 -0.1 0.3 -0.3 0.2 0.5 0.7 0.4 -0.0 0.5 0.4 0.1
Illnesses of father: None of the above (group 1) 1.4 1.7 5.5 2.3 0.6 -0.2 0.9 1.0 1.1 1.3 1.5 1.3 2.3 0.8 0.7 -1.6 0.8 0.9 1.1 1.4 1.7
Smoking status: Current 0.3 0.4 3.2 0.5 0.7 -1.8 0.2 0.1 0.1 0.2 -0.8 -0.1 0.3 0.7 0.1 -1.2 -0.0 -0.8 -0.1 -0.0 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 3.0 -1.4 -1.1 1.7 -1.5 -1.3 -1.2 -1.2 -1.1 -1.4 -1.4 -0.6 -1.4 0.9 -1.2 -0.9 -1.7 -1.6 -1.7
Whole body water mass 0.2 1.3 5.6 -0.3 -1.9 -0.8 -0.1 -1.1 -1.1 0.1 1.6 -0.2 -1.0 -1.0 -1.0 2.1 -0.7 2.4 0.1 -0.4 -0.2
Leg predicted mass (right) 0.1 0.7 3.3 -0.1 -1.2 -0.7 -0.0 -0.7 -0.7 0.3 1.5 -0.3 -0.5 -0.9 -0.6 1.2 -0.3 1.8 0.2 -0.1 0.2
Arm fat mass (left) 0.8 3.3 10.7 1.8 1.0 -2.2 2.4 1.1 1.1 2.9 2.6 2.2 0.5 1.6 1.1 -0.2 1.7 3.3 1.9 0.6 0.9
Number of self-reported non-cancer illnesses 0.1 0.2 2.0 -0.5 0.0 -1.4 0.5 -0.2 -0.3 -0.2 0.0 0.1 -0.3 -0.2 -0.1 0.7 -0.1 0.9 0.3 -0.1 -0.5
Average weekly champagne plus white wine intake 0.3 0.4 2.0 -0.2 1.4 0.1 0.2 0.6 0.4 0.1 -1.0 0.6 0.3 0.3 0.8 -1.0 0.5 0.1 0.7 0.7 0.5
Miserableness 0.3 0.5 3.0 -0.4 -0.5 -0.0 0.4 -0.5 -0.5 0.7 1.1 0.5 -0.4 0.6 -0.5 1.2 -0.2 1.7 0.1 -0.8 -0.7
Guilty feelings 0.1 0.1 0.5 0.1 0.3 -0.0 -0.6 -0.0 -0.1 -0.6 -0.1 -0.3 0.1 -0.2 0.0 -0.2 -0.2 -0.4 -0.1 0.7 0.3
Wears glasses or contact lenses 1.4 1.6 3.1 -0.9 -1.8 0.3 -1.5 -1.6 -1.5 -1.5 0.5 -1.5 -0.8 -0.8 -1.5 1.6 -1.6 -0.4 -1.4 -1.2 -1.3
Ever taken oral contraceptive pill 1.8 2.0 3.4 -1.6 -1.3 0.7 -1.6 -1.6 -1.6 -1.4 -0.4 -1.5 -1.8 -1.2 -1.5 1.3 -1.6 -0.8 -1.6 -1.8 -1.5
Hearing aid user 0.1 0.1 0.7 -0.1 -0.2 0.1 0.2 -0.1 -0.1 -0.4 -0.5 0.0 -0.2 -0.8 -0.2 0.2 -0.4 0.1 0.1 0.2 -0.1
Mother’s age at death 0.8 1.0 5.4 0.2 1.1 -0.8 0.1 0.6 0.5 -0.6 -1.2 -0.4 1.4 0.5 0.8 -2.3 0.2 -1.4 0.4 1.5 0.9
Financial situation satisfaction 1.4 1.7 7.5 1.2 0.5 -0.8 1.2 0.8 0.8 1.9 2.4 1.6 0.7 0.7 0.6 0.5 1.1 2.7 1.4 0.6 1.2
Tinnitus: Yes, now most or all of the time 0.9 1.1 7.7 0.0 0.0 1.5 -1.2 0.2 0.3 -1.1 -1.1 -1.5 0.2 -0.9 0.0 -0.9 -0.1 -2.8 -1.1 -0.0 0.0
Commuting to job workplace: Public transport 0.9 1.1 3.6 -0.2 1.6 -1.4 -0.2 1.0 0.8 0.6 0.1 0.2 1.9 0.9 1.2 -1.6 1.2 -0.1 0.9 0.5 1.3
Eye problems/disorders: Glaucoma 0.7 0.9 5.0 -0.0 -1.4 2.2 -1.3 -0.8 -0.8 -0.4 1.4 -0.9 -0.4 -0.8 -0.9 0.5 -0.6 0.3 -0.7 -0.5 -0.0
Medication: Blood pressure 0.2 0.4 1.8 -0.6 0.1 -1.3 0.6 -0.1 -0.1 0.2 -0.8 0.6 -0.7 0.2 -0.1 0.7 0.0 1.0 0.1 -0.6 -1.0
Pain type(s) experienced in last month: Hip pain 0.3 0.4 3.5 0.3 0.1 -1.9 0.5 0.4 0.4 -0.1 -0.1 0.1 0.6 0.1 0.2 -0.3 0.1 -0.4 0.2 1.0 0.7
Supplements: Fish oil (including cod liver oil) 0.4 0.6 4.8 0.6 1.4 -0.3 0.5 0.5 0.6 0.6 0.1 0.6 0.4 0.6 0.5 -2.2 0.5 -0.3 0.3 0.4 0.3
High cholesterol (Self-reported) 2.1 3.7 6.6 -2.3 -1.1 0.4 -2.0 -2.3 -2.4 -1.9 -1.4 -2.0 -2.3 -1.3 -2.1 0.5 -2.2 -1.1 -2.2 -2.4 -2.6
Medication: Bendroflumethiazide 0.4 0.7 3.5 -0.2 0.3 0.8 -1.1 0.4 0.3 -1.0 -1.7 -0.8 -0.0 -0.9 0.5 -0.3 0.2 -1.9 -0.6 0.1 -0.0
Medication: Paracetamol 0.5 0.8 3.1 -0.7 -0.8 -1.8 -0.5 -0.5 -0.4 -0.7 -0.7 -0.7 -0.2 -1.5 -0.7 0.7 -0.7 -0.8 -1.0 -0.9 -1.0
Medication: Lisinopril 2.9 3.7 6.2 -2.5 -1.4 1.8 -2.4 -2.1 -2.3 -2.1 -1.0 -2.0 -2.3 -1.5 -1.6 2.2 -1.8 -0.6 -1.8 -2.2 -2.2
Medication: Atorvastatin 0.6 0.8 2.0 -1.0 -0.4 0.5 -1.3 -0.6 -0.7 -1.1 -0.9 -1.1 -1.3 -0.7 -0.5 0.3 -0.6 -1.4 -1.0 -0.8 -0.7
Illnesses of father: High blood pressure 0.7 0.9 2.0 -1.4 -1.0 0.3 -1.2 -0.8 -0.9 -1.4 -0.7 -1.0 -1.1 0.2 -0.6 1.4 -0.7 -0.5 -0.9 -0.9 -1.0
Alcohol drinker status: Never 0.7 0.9 5.8 0.1 -1.4 0.2 0.7 -0.2 -0.1 0.1 -0.2 0.7 -1.9 0.6 -0.4 2.4 -0.2 1.0 -0.1 -0.7 -1.0
Ever smoked 1.6 2.7 9.0 -2.0 -0.2 -0.2 -1.5 -1.4 -1.7 -2.6 -2.0 -2.4 -0.5 -2.2 -1.1 0.1 -1.8 -3.0 -1.4 -0.3 -0.9
Basal metabolic rate 0.2 1.2 7.3 0.1 -1.5 -1.3 0.4 -0.7 -0.7 0.7 1.9 0.3 -0.8 -0.7 -0.7 1.9 -0.3 2.7 0.4 -0.2 0.0
Leg fat percentage (left) 0.7 2.4 7.1 1.3 1.5 -2.7 2.1 1.0 1.1 2.4 1.8 1.9 0.4 1.8 0.9 -0.7 1.5 2.2 1.3 0.4 0.3
Arm fat-free mass (left) 0.2 1.1 7.4 0.0 -1.3 -1.4 0.3 -0.7 -0.7 0.6 1.9 0.2 -0.7 -0.5 -0.7 1.6 -0.2 2.7 0.4 -0.4 -0.1
Number of operations (self-reported) 0.3 0.4 2.8 0.7 -0.5 0.6 -0.6 0.2 0.3 -0.3 1.7 -0.7 0.2 -0.6 0.1 0.1 0.1 -0.9 -0.2 0.6 0.8
Average weekly beer plus cider intake 0.8 1.2 3.5 0.0 -0.4 1.4 -1.5 -0.8 -0.6 -0.9 -0.8 -1.4 -0.1 -0.5 -1.1 -1.4 -1.0 -1.9 -1.8 -1.2 -1.0
Irritability 0.9 1.5 6.5 -1.0 -1.7 -0.6 0.4 -1.2 -1.3 -0.6 -1.3 0.2 -1.8 -0.5 -1.0 2.5 -1.1 1.4 -0.2 -0.6 -1.5
Risk taking 2.0 3.0 6.7 2.6 0.8 0.1 2.2 1.8 1.8 2.1 1.0 2.2 1.1 2.2 1.6 -1.0 1.7 1.5 2.0 1.7 1.7
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.2 0.1 -0.7 0.1 0.4 -0.4 -0.2 0.4 -0.0 -0.0 -0.8 -0.9 -0.6 0.5 -0.4 0.2 -0.5 -1.0 -1.1
Fractured/broken bones in last 5 years 2.5 3.2 5.9 1.4 2.1 -2.3 1.8 1.3 1.3 1.6 1.7 1.2 1.9 1.8 1.3 -2.4 1.2 1.3 2.0 2.3 2.4
Age started oral contraceptive pill 0.4 0.6 1.2 1.1 -0.1 1.1 0.5 0.9 1.0 0.6 0.6 0.5 0.7 0.6 0.7 -0.6 0.7 0.3 0.7 0.7 1.1
Diastolic blood pressure, automated reading 0.6 1.8 7.9 -1.5 -0.6 0.2 -1.0 -1.3 -1.3 0.6 1.8 -0.5 -1.5 -0.5 -1.1 1.9 -0.4 1.6 -0.8 -2.8 -1.6
Ever depressed for a whole week 2.0 2.5 5.5 1.8 0.9 -2.3 2.1 1.6 1.8 1.9 1.2 2.3 0.6 2.0 1.2 -0.2 1.5 1.6 1.5 1.1 1.0
Unable to work because of sickness or disability 0.4 0.5 2.8 0.6 -0.6 -1.7 1.1 -0.0 0.1 0.6 -0.5 0.4 -0.7 -1.2 -0.3 0.5 -0.0 0.7 0.1 -0.1 -0.4
Commuting to job workplace: Cycle 2.1 2.5 3.6 1.6 1.1 -1.7 1.5 1.8 1.8 1.2 0.8 1.9 1.9 1.4 1.8 -0.4 1.7 1.4 1.9 1.8 1.8
Myopia 0.5 0.7 1.9 0.3 -1.4 1.0 -1.1 -0.6 -0.5 -0.7 0.6 -1.1 -0.4 -1.2 -0.8 0.3 -0.8 -1.2 -1.2 -0.4 -0.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 3.7 1.9 -0.5 0.7 1.2 0.7 0.9 1.5 1.0 1.2 -0.1 0.7 0.3 0.1 0.7 0.5 0.5 0.3 0.6
Cholesterol lowering medication 0.3 0.5 1.5 -0.7 -0.0 -0.9 -0.7 -0.3 -0.3 -0.4 -0.6 -0.5 -1.2 -0.1 -0.3 -0.4 -0.2 -0.8 -0.8 -1.1 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 3.4 -1.0 0.7 -1.9 0.6 -0.2 -0.4 0.2 0.2 -0.1 -0.1 -0.0 0.1 -0.6 0.1 0.3 0.4 -0.0 -0.3
Pain experienced in last month 0.1 0.1 0.5 0.1 0.2 0.7 -0.1 0.3 0.3 0.5 0.7 0.4 0.3 0.3 0.3 -0.0 0.4 0.5 0.3 -0.1 0.4
Supplements: Calcium 0.8 0.9 2.4 1.0 0.5 -1.1 1.1 1.3 1.3 0.1 -0.8 0.7 0.3 0.1 1.3 -0.1 1.0 -0.5 0.9 1.6 0.9
Basal cell carcinoma (self-reported) 0.3 0.4 2.2 1.1 0.2 0.5 -0.1 0.6 0.7 0.6 1.5 0.1 0.1 0.9 0.4 -0.7 0.6 -0.1 0.1 0.3 0.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 3.3 0.3 0.5 -1.8 0.6 0.1 0.1 0.1 -0.7 0.5 0.4 -0.7 0.1 -0.5 0.0 0.7 0.4 0.6 0.0
Deep venous thrombosis (DVT) (self-reported) 2.9 3.8 11.8 1.1 2.5 -3.4 2.3 1.7 1.8 1.7 -0.3 2.1 2.1 2.2 1.6 -2.7 1.6 1.2 1.8 1.4 1.1
Heart disease (siblings) 0.1 0.2 1.3 -0.0 -0.1 0.2 0.6 -0.0 -0.0 0.6 0.4 0.4 -0.2 0.2 -0.0 -0.0 0.1 1.1 0.4 -0.2 -0.0
Alcohol drinker status: Previous 0.5 0.6 1.5 1.1 0.2 0.2 1.0 1.1 1.2 1.1 0.4 0.8 0.5 0.1 0.9 -0.1 1.2 0.3 0.7 0.5 0.5
Pack years of smoking 0.5 0.7 3.5 0.1 1.3 -0.9 -0.5 0.2 0.1 -0.7 -0.1 -0.9 1.1 0.1 0.4 -1.9 -0.1 -1.3 0.1 1.0 0.8
Impedance of whole body 0.1 0.7 3.3 -0.3 1.1 0.1 0.7 0.8 0.6 -0.6 -1.8 0.2 0.3 0.3 1.1 -0.2 0.5 -1.6 0.6 1.1 0.3
Leg fat mass (left) 0.4 1.7 6.8 0.9 0.9 -2.6 1.6 0.6 0.6 2.0 1.9 1.4 0.2 1.1 0.6 -0.2 1.1 2.3 1.1 0.3 0.3
Arm predicted mass (left) 0.2 1.1 6.4 0.1 -1.4 -1.4 0.1 -0.9 -0.9 0.5 2.0 -0.0 -0.6 -0.6 -0.9 1.6 -0.4 2.5 0.2 -0.4 -0.1