Hub : Genes

ZNF273

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1850 0.0440 0.0e+00 0.185 0.215 0.215 0.213 0.158 5.6e-22 1.2e-25 1.0e-25 2.1e-25 9.3e-19
2 GTEx Adipose Subcutaneous 0.1160 0.0410 1.2e-06 0.092 NA 0.081 NA 0.088 5.7e-08 NA 3.9e-07 NA 1.1e-07
3 GTEx Adipose Visceral Omentum 0.2460 0.0630 1.6e-13 0.217 NA 0.278 NA 0.288 1.6e-11 NA 8.6e-15 NA 2.6e-15
4 GTEx Artery Aorta 0.1480 0.0540 6.9e-07 0.174 NA 0.102 NA 0.153 7.3e-10 NA 2.9e-06 NA 8.2e-09
5 GTEx Artery Coronary 0.1050 0.0490 2.1e-03 0.106 NA 0.105 NA 0.089 2.0e-04 NA 2.1e-04 NA 6.4e-04
6 GTEx Cells Transformed fibroblasts 0.1150 0.0550 2.8e-04 0.053 NA 0.066 NA 0.059 7.3e-05 NA 1.1e-05 NA 3.0e-05
7 GTEx Colon Sigmoid 0.1560 0.0720 2.6e-03 -0.007 NA -0.008 NA -0.007 7.6e-01 NA 7.9e-01 NA 7.3e-01
8 GTEx Colon Transverse 0.1260 0.0420 1.4e-06 0.152 NA 0.094 NA 0.120 1.0e-07 NA 3.1e-05 NA 2.4e-06
9 GTEx Esophagus Mucosa 0.3290 0.0620 1.1e-16 0.287 NA 0.314 NA 0.326 1.9e-19 NA 1.9e-21 NA 2.3e-22
10 GTEx Heart Atrial Appendage 0.1730 0.0520 2.4e-08 0.222 NA 0.268 NA 0.261 2.5e-10 NA 2.0e-12 NA 4.4e-12
11 GTEx Heart Left Ventricle 0.2585 0.0808 1.6e-09 0.217 NA 0.205 NA 0.168 8.2e-12 NA 3.8e-11 NA 2.8e-09
12 GTEx Nerve Tibial 0.2485 0.0604 1.1e-12 0.202 NA 0.199 NA 0.188 2.7e-14 NA 4.3e-14 NA 2.3e-13
13 GTEx Ovary 0.2310 0.1330 9.7e-03 -0.011 NA 0.016 NA -0.012 7.7e-01 NA 1.3e-01 NA 9.3e-01
14 GTEx Pancreas 0.2570 0.0630 1.6e-11 0.270 NA 0.338 NA 0.212 7.6e-12 NA 5.7e-15 NA 2.3e-09
15 GTEx Pituitary 0.4080 0.0970 1.7e-07 0.326 NA 0.298 NA 0.059 5.6e-09 NA 3.3e-08 NA 1.4e-02
16 GTEx Skin Sun Exposed Lower leg 0.2280 0.0560 4.0e-09 0.078 NA 0.102 NA 0.107 5.1e-07 NA 8.7e-09 NA 3.6e-09
17 GTEx Stomach 0.0650 0.0300 3.7e-03 0.025 NA 0.015 NA 0.025 2.3e-02 NA 6.2e-02 NA 2.3e-02
18 GTEx Thyroid 0.2670 0.0570 0.0e+00 0.225 NA 0.296 NA 0.259 3.7e-17 NA 5.6e-23 NA 7.8e-20
19 METSIM Adipose 0.0998 0.0328 6.0e-10 0.067 0.064 0.065 0.065 0.058 2.5e-10 6.2e-10 5.4e-10 6.0e-10 4.0e-09
20 ROSMAP Brain Pre-frontal Cortex 0.2101 0.0460 0.0e+00 0.075 0.167 0.173 0.174 0.176 6.0e-10 6.6e-21 1.1e-21 8.2e-22 4.7e-22
21 TCGA Esophageal Carcinoma 0.1110 0.0570 3.8e-04 0.156 0.078 0.098 NA 0.117 1.2e-05 1.8e-03 5.2e-04 NA 1.5e-04
22 TCGA Head and Neck Squamous Cell Carcinoma 0.0415 0.0206 4.8e-06 0.047 0.046 0.045 NA 0.043 4.4e-06 6.5e-06 7.6e-06 NA 1.2e-05
23 TCGA Lung Squamous Cell Carcinoma 0.0359 0.0193 7.5e-06 0.049 0.045 0.039 NA 0.037 2.6e-06 7.7e-06 3.0e-05 NA 4.0e-05
24 TCGA Pheochromocytoma and Paraganglioma 0.0800 0.0470 2.3e-03 0.019 0.044 0.013 NA -0.002 5.9e-02 7.8e-03 9.8e-02 NA 3.9e-01
25 TCGA Thyroid Carcinoma 0.1220 0.0560 3.0e-04 0.004 0.035 0.028 NA 0.013 1.2e-01 2.2e-04 9.5e-04 NA 1.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Bipolar Disorder (2018) 2.7 4.3 7.2 0.7 2.1 2.5 2.6 2.7 0.3 1.2 1.9 -2.3 2.3 2.2 1.5 0.0 2.5 1.7 -2.1 1.8 2.5 2.4 2.2 -2.2 -2.4 -2.3 2.7 1.5
Bipolar Disorder or Schizophrenia 0.6 1.4 2.8 0.5 1.0 1.5 1.5 1.5 -0.4 0.4 1.0 -1.5 1.5 1.2 0.7 -0.9 1.4 1.3 -1.3 1.1 1.7 1.6 1.1 -1.1 -1.3 -1.4 1.4 0.6
Depressed Affect (Nagel 2018) 0.8 1.7 4.1 1.2 1.6 1.7 1.1 1.3 1.1 2.0 1.5 -0.2 1.4 1.8 1.4 -0.8 1.4 1.9 0.7 0.6 1.4 1.8 0.1 -1.7 -0.3 -1.1 1.3 0.7
Depression (Nagel 2018) 1.0 1.5 8.4 1.0 0.8 0.6 -0.6 0.0 1.6 2.3 0.6 1.5 0.4 0.5 1.0 -2.9 0.2 1.3 2.4 0.4 0.9 0.7 -1.6 -0.0 1.4 0.4 -0.0 0.3
Intelligence (Savage-Jansen 2018) 0.2 0.5 3.8 -0.1 -0.6 -0.4 0.6 0.1 -0.5 -0.3 -0.4 -0.9 -0.3 -0.2 -0.8 1.0 -0.0 -1.0 -1.9 -0.1 -1.0 -0.3 0.1 -0.1 -1.2 -0.4 -0.2 -0.8
Neuroticism (Nagel 2018) 0.4 0.8 3.1 0.6 1.2 1.1 0.5 0.8 0.5 1.8 0.9 0.3 0.8 1.1 0.9 -1.5 0.8 1.0 1.1 0.4 1.2 1.1 -0.4 -0.9 0.3 -0.5 0.7 0.5
Schizophrenia (2018) 0.1 0.1 1.3 0.1 -0.4 -0.2 -0.2 -0.2 -0.8 -0.5 -0.3 -0.0 0.0 -0.2 -0.4 -1.2 -0.3 0.3 0.1 -0.1 0.1 0.1 -0.4 0.3 0.3 0.1 -0.4 -0.4
Schizophrenia vs Biploar Disorder 1.5 2.0 3.8 -1.6 -1.6 -1.7 -1.6 -1.3 -1.4 -1.0 -1.9 1.6 -1.2 -1.8 -1.1 0.8 -1.5 -1.1 0.4 -1.9 -1.5 -0.9 -0.7 1.9 1.4 1.7 -1.7 -0.6
Worry (Nagel 2018) 0.4 0.9 2.5 0.7 1.2 1.2 0.9 0.9 0.5 1.2 0.9 -0.2 1.2 1.1 0.7 -1.1 1.1 1.3 0.4 0.5 1.2 1.6 -0.1 -1.0 -0.3 -0.9 0.7 0.1
Alzheimer’s Disease (in mother) 0.3 0.3 3.1 0.8 -0.5 -0.2 0.4 -0.6 -0.5 -0.4 0.1 -0.2 0.4 0.3 -0.8 -1.8 0.1 0.4 0.0 -0.7 -0.2 0.5 -0.3 -0.2 -0.3 -0.5 -0.3 -0.9
Alzheimer’s Disease (in father) 0.7 0.8 3.6 -0.6 -0.0 -0.4 -1.4 -0.5 -0.1 0.0 -0.6 1.3 -0.8 -0.6 0.7 -0.6 -0.9 0.0 1.9 0.1 0.8 -0.4 -1.1 0.8 1.9 1.2 -0.5 0.4
Alzheimer’s Disease (including proxy) 0.4 0.6 2.4 -0.3 -0.8 -0.7 -0.6 -1.1 -0.7 -0.6 -0.4 0.8 -0.8 -0.3 -0.6 -1.6 -0.8 -0.3 1.1 -0.9 -0.4 -0.4 -0.8 0.5 1.0 0.4 -0.6 -0.5
Crohns Disease (2017) 1.0 2.3 4.1 1.9 1.5 1.7 1.5 1.3 1.7 1.3 2.0 -1.1 1.8 1.8 1.5 -1.4 1.8 2.0 0.1 1.5 1.5 1.7 0.7 -1.7 -0.9 -1.4 1.6 0.8
Irritable Bowel Disease (IBD) 0.2 0.5 2.4 0.8 0.5 0.5 0.1 0.2 0.7 0.6 0.8 0.3 0.8 0.6 1.1 -1.5 0.6 1.4 0.9 0.6 0.8 0.5 0.5 -0.4 0.3 0.1 0.4 1.0
Ulcerative Colitis (UC) 0.2 0.3 1.2 -0.2 -0.1 -0.3 -0.8 -0.4 -0.1 -0.0 -0.1 1.0 -0.1 -0.3 0.6 -1.1 -0.2 0.6 1.1 0.0 0.2 -0.7 0.1 0.4 0.9 1.0 -0.4 0.7
Major Depression (MDD) 0.6 0.7 3.9 -0.0 0.1 -0.1 -0.1 0.1 0.3 1.3 -0.1 0.1 -0.5 -0.7 -0.9 -2.0 -0.2 -1.0 -0.4 0.4 -0.1 -1.2 -1.9 1.1 0.1 0.1 -0.8 -1.4
Reaction Time 0.6 1.0 3.7 1.2 1.1 0.9 0.2 0.7 1.8 1.9 0.8 0.5 1.2 0.8 1.3 -0.9 0.7 1.9 1.1 1.0 1.1 1.2 -0.4 -0.4 0.2 -0.2 0.5 0.5
Verbal and Numeric Reasoning (VNR) 0.1 0.4 2.7 0.3 0.0 0.0 0.8 0.5 -0.2 0.2 0.2 -1.0 0.1 0.1 -0.7 0.3 0.3 -1.1 -1.6 0.3 -0.2 -0.2 0.1 -0.2 -1.1 -0.6 0.2 -0.4
Breast Cancer 1.9 4.6 8.8 -1.3 -2.3 -2.5 -2.6 -2.5 -1.3 -1.1 -2.2 2.3 -2.0 -2.7 -1.7 -1.2 -2.4 -0.8 1.5 -2.1 -1.9 -2.6 -2.5 2.8 2.2 2.6 -3.0 -1.5
Ovarian Cancer 0.6 0.8 2.2 -0.5 -1.0 -0.9 -0.4 -0.7 -0.2 0.0 -0.7 0.1 -0.9 -0.9 -1.3 -1.5 -0.7 -1.2 -0.6 -0.4 -0.9 -1.1 -1.4 0.9 0.0 0.4 -1.0 -1.5
Prostate Cancer 0.1 0.2 1.2 0.6 -0.1 0.2 -0.1 -0.0 0.5 0.5 0.2 0.1 0.3 0.2 0.1 -1.0 0.0 0.1 0.4 0.0 0.2 1.1 0.4 -0.1 0.1 0.2 0.2 0.8
Age at First Birth 2.4 3.5 7.0 1.1 2.0 2.3 1.6 2.4 1.4 1.3 2.1 -1.8 1.6 1.8 2.0 0.9 2.0 1.4 -1.2 2.4 2.3 2.0 1.8 -1.9 -1.7 -1.8 2.6 1.7
Bipolar Disorder (2011) 0.5 0.5 2.7 -0.5 0.1 0.3 1.2 0.6 0.0 -0.3 0.3 -1.4 0.0 0.6 -0.3 0.2 0.5 -0.4 -1.6 0.2 0.2 0.1 0.7 -0.6 -1.0 -1.2 0.7 -0.7
Body Mass Index (BMI) (2010) 0.3 0.5 4.6 0.2 0.0 -0.0 -0.6 -0.6 0.8 0.8 0.2 0.8 -0.6 -0.1 0.4 -2.1 -0.3 0.3 1.3 0.2 -0.1 -0.3 -0.9 0.1 1.0 0.3 -0.1 -0.0
Coronary Artery Disease (CAD) 0.2 0.2 0.6 0.2 0.4 0.5 0.5 0.3 0.3 0.4 0.5 0.1 0.2 0.5 0.5 -0.3 0.4 0.8 0.8 0.3 -0.0 0.2 0.6 -0.7 -0.1 -0.3 0.6 0.8
Crohns Disease (2012) 2.3 3.8 7.8 1.6 2.4 2.4 1.4 2.3 2.1 2.2 2.1 -1.0 1.9 2.0 2.5 -0.6 2.1 2.2 0.4 2.4 2.8 2.0 1.1 -1.9 -0.8 -1.4 2.4 2.1
Mean Putamen Volume 0.2 0.2 1.0 -0.0 -0.4 -0.2 -0.4 -0.1 -0.2 -0.4 0.1 -0.8 0.3 -0.0 -0.4 1.0 0.3 -0.2 -0.9 -0.1 -1.0 -0.7 0.4 0.1 -0.9 -0.1 -0.1 0.0
Fasting Glucose 0.6 0.8 3.3 1.1 1.2 0.9 -0.9 0.2 0.9 1.3 0.7 0.5 -0.0 0.6 1.0 -1.8 -0.1 0.3 1.7 0.5 1.3 0.4 -0.1 -0.3 0.9 0.2 0.5 0.5
HbA1C 0.5 0.5 3.1 1.1 0.6 0.6 0.1 0.7 1.3 1.8 0.4 -0.2 0.6 -0.0 0.2 -1.1 0.7 0.2 -0.1 1.4 0.3 0.1 -0.2 0.5 -0.5 0.1 0.3 0.5
HDL Cholesterol 2.0 3.4 5.6 1.6 1.7 2.0 2.2 1.9 0.8 0.1 1.9 -2.0 2.3 2.3 1.5 1.5 2.3 2.4 -1.2 1.4 1.4 1.9 2.0 -2.4 -2.2 -2.3 1.9 0.3
LDL Cholesterol 0.3 0.5 2.3 -0.6 -0.3 -0.1 0.5 -0.3 -0.6 -1.5 0.5 -0.9 -0.5 0.6 -0.2 1.4 -0.1 -0.8 -0.6 -0.4 -0.9 0.2 1.4 -0.7 -0.3 -0.7 0.7 0.1
Lupus 1.9 2.8 7.7 1.1 1.6 1.8 2.8 2.0 0.4 0.7 2.2 -2.3 1.5 2.3 0.4 0.2 2.1 0.7 -1.9 0.9 1.0 0.6 0.9 -2.2 -2.2 -2.7 1.8 -0.8
Neuroticism (2016) 0.2 0.2 0.8 -0.1 -0.1 -0.0 -0.4 -0.1 -0.5 0.3 -0.2 0.6 -0.6 -0.3 -0.4 -0.7 -0.5 -0.2 0.7 -0.7 -0.6 -0.7 -0.9 0.4 0.7 0.4 -0.4 -0.3
Primary Biliary Cirrhosis 0.5 0.7 8.2 0.9 -0.2 -0.0 0.6 -0.1 0.0 1.0 0.2 -0.5 0.8 -0.0 -1.0 -2.9 0.5 0.6 -0.7 0.0 -0.8 -0.2 -1.2 0.3 -0.8 -0.3 -0.6 -1.0
Rheumatoid Arthritis 0.9 1.3 4.1 1.0 0.5 0.7 1.7 0.8 -0.1 -0.4 1.1 -1.8 1.5 1.3 0.2 1.2 1.5 0.7 -1.6 0.1 -0.1 1.0 1.4 -1.4 -2.0 -1.5 0.8 -0.2
Schizophrenia (2014) 0.1 0.3 1.6 -0.9 -0.7 -0.4 -0.3 -0.4 -1.2 -1.3 -0.7 0.0 0.1 -0.3 -0.2 -0.1 -0.3 0.1 -0.1 -0.6 0.0 0.9 0.7 0.1 0.3 0.3 -0.2 0.5
Triglycerides 0.2 0.4 2.5 0.3 0.4 -0.0 -0.4 -0.0 0.5 1.0 0.2 0.5 -0.4 -0.3 -0.1 -1.6 -0.3 -0.5 0.8 0.3 0.2 -0.7 -1.4 0.6 0.7 0.2 -0.3 -0.4
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.0 0.2 0.6 0.5 0.9 0.6 0.2 0.1 0.4 -0.8 0.6 0.8 0.2 0.8 0.6 0.3 -0.8 0.6 0.3 0.9 0.6 -0.9 -0.6 -1.0 0.8 -0.1
Ulcerative Colitis 0.3 0.4 1.5 0.5 0.6 0.7 0.1 0.5 0.9 0.4 0.7 0.1 0.7 0.5 1.2 -0.6 0.6 1.0 0.4 0.8 0.8 -0.0 0.8 -0.6 -0.1 -0.0 0.6 1.1
Blood Eosinophil Count 0.4 2.8 15.7 1.2 0.1 -0.5 -1.7 -0.5 1.8 1.9 -0.4 1.8 -0.1 -1.0 -0.1 -3.8 -0.8 -0.3 2.2 0.7 -0.0 -1.9 -4.0 1.8 1.6 1.4 -1.9 -1.7
Blood Platelet Count 0.2 2.9 7.2 -0.4 -2.7 -2.3 -1.4 -2.6 -1.6 -2.0 -1.9 1.4 -1.0 -1.8 -2.0 -1.3 -1.8 -0.4 0.3 -2.4 -2.6 -0.5 -0.8 1.6 0.8 1.8 -2.2 -0.9
Blood Red Count 0.2 2.0 7.1 1.2 1.1 1.2 2.1 1.5 0.5 -0.5 1.4 -2.7 0.9 1.5 0.0 1.3 1.2 -0.2 -2.2 1.3 0.9 0.2 0.5 -1.5 -1.9 -2.5 1.4 -1.6
Blood White Count 1.1 8.4 47.7 1.1 -0.4 -1.0 -3.1 -1.6 1.7 4.3 -1.5 4.0 -0.6 -2.5 -0.2 -6.9 -1.2 1.9 3.8 0.1 -1.0 -2.1 -5.7 3.5 2.6 3.4 -3.4 -0.8
Heel T-Score 0.2 1.4 3.5 1.4 1.5 1.4 1.2 1.6 0.6 1.4 1.1 -1.2 1.4 1.0 0.6 -0.7 1.4 1.2 -0.9 1.7 1.9 0.8 -0.1 -0.6 -1.3 -1.1 0.9 0.1
BMI 0.3 1.8 9.4 0.1 -0.4 -0.7 -1.2 -0.9 0.7 1.9 -0.7 1.5 -0.9 -1.3 -0.7 -3.1 -0.8 -0.7 1.2 -0.1 -1.0 -2.3 -2.7 1.7 1.0 1.2 -1.5 -0.8
Height 0.8 15.3 28.3 -4.8 -4.5 -4.8 -4.6 -4.7 -2.8 -3.2 -4.8 3.9 -4.7 -4.6 -2.7 2.5 -4.9 -5.3 1.5 -4.4 -3.6 -2.5 0.0 4.0 3.8 4.8 -3.5 1.0
Waist Hip Ratio (WHR) 0.1 0.2 0.8 -0.8 -0.1 -0.3 -0.7 -0.2 -0.1 0.0 -0.7 0.8 -0.2 -0.5 0.2 -0.1 -0.5 -0.1 0.6 -0.2 0.5 -0.0 -0.4 0.6 0.8 0.9 -0.4 0.6
Systolic Blood Pressure 0.2 0.9 2.6 -0.9 -1.2 -1.1 0.0 -1.0 -1.3 -1.4 -0.7 -0.2 -1.0 -0.6 -1.5 1.3 -0.9 -1.5 -1.2 -1.6 -0.6 -0.8 0.5 0.3 -0.0 0.0 -0.3 -0.6
Smoking Status 0.2 0.4 2.8 1.1 0.2 0.2 -0.2 0.2 1.7 1.0 0.3 0.3 0.2 0.1 0.5 -1.5 0.2 0.2 0.6 0.7 -0.3 -0.7 -0.7 0.0 0.1 0.1 -0.2 -0.2
Allergy or Eczema 1.3 3.4 13.3 0.6 1.9 1.8 -0.0 1.3 2.0 1.3 1.4 0.6 1.3 1.6 3.4 -0.3 1.1 2.6 1.9 2.0 2.5 2.3 1.9 -1.6 0.6 -0.0 2.1 3.6
Cardiovascular Disease 0.3 0.8 4.1 0.3 0.0 0.2 1.5 0.4 -0.7 -0.5 0.1 -1.5 1.1 0.8 -0.7 0.3 1.1 0.8 -2.0 -0.5 -0.5 -0.1 0.3 -0.6 -2.0 -1.0 -0.2 -1.0
Hypothyroidism (self reported) 0.2 0.5 5.2 0.9 -0.0 -0.1 -0.1 -0.4 -0.1 0.5 -0.0 0.4 0.3 -0.1 -0.4 -2.3 0.1 0.4 0.8 -0.3 -0.2 -1.0 -1.2 0.5 0.2 0.2 -0.7 -0.7
Respiratory disease 0.2 0.4 3.4 0.8 0.2 0.3 -0.1 -0.1 1.8 1.1 0.3 0.2 -0.1 0.2 0.4 -1.4 0.1 0.8 0.7 0.7 0.2 0.8 -0.6 -0.1 0.3 -0.0 0.3 0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.6 0.2 -0.1 -0.2 -0.7 -0.5 0.2 0.6 -0.5 1.1 0.2 -0.5 0.3 -1.2 -0.2 0.8 1.3 -0.2 -0.0 0.1 -0.5 0.8 0.7 0.9 -0.6 0.8
Lung FEV1/FVC ratio 0.2 1.2 5.0 0.0 -0.5 -0.7 -1.3 -1.2 0.4 0.8 -0.5 2.0 -0.6 -0.7 -0.5 -1.8 -1.0 -0.2 2.2 -1.0 -0.8 -0.7 -1.8 1.1 1.5 1.1 -1.2 -0.5
Lung FVC 1.6 8.3 15.1 2.4 2.6 3.1 3.7 3.6 1.2 1.1 3.0 -3.9 2.8 3.1 1.6 2.2 3.0 1.0 -3.3 2.8 2.8 3.2 3.1 -3.0 -3.4 -3.5 3.9 1.4
Neuroticism 0.3 0.8 1.9 0.8 1.3 1.1 0.3 0.9 0.9 0.8 1.1 0.0 0.5 1.0 1.4 -0.8 0.7 1.1 1.1 0.8 1.1 0.6 0.3 -1.0 0.5 -0.5 0.9 0.8
Chronotype (morning person) 0.1 0.3 2.4 1.0 -0.1 0.1 0.4 -0.2 0.5 0.4 0.7 -0.1 0.7 0.3 -0.2 -1.6 0.6 0.7 0.1 0.0 -0.3 -0.4 -0.6 -0.1 -0.7 -0.3 -0.3 -0.5
Hair Pigment 0.0 1.1 3.9 0.3 1.0 0.8 -1.6 0.4 0.3 1.0 -0.4 1.8 0.6 -0.7 0.4 -0.9 -0.2 1.2 1.6 -0.1 2.0 0.2 -1.1 1.3 1.5 1.5 -0.5 1.3
Tanning 0.1 0.7 2.1 -0.0 0.6 0.8 0.6 1.1 0.6 -0.0 0.6 -1.0 -0.0 0.4 0.8 1.4 0.3 -0.5 -0.9 1.0 1.4 1.0 1.3 -0.5 -0.4 -0.7 1.5 1.1
Hand grip strength (left) 0.5 1.4 3.6 -1.2 -1.3 -1.5 -1.6 -1.3 -0.3 -1.4 -1.2 0.8 -1.8 -1.6 -0.6 1.4 -1.7 -1.9 0.7 -0.5 -1.0 -1.0 -0.1 1.1 1.4 1.3 -0.8 -0.2
Number of treatments/medications taken 1.0 1.8 4.0 1.2 0.9 1.3 2.0 1.1 1.0 0.9 1.4 -1.5 1.4 1.9 0.6 -0.6 1.8 1.8 -1.2 0.6 -0.3 1.1 1.0 -2.0 -1.9 -1.8 1.3 0.1
Average weekly spirits intake 0.4 0.5 2.9 0.1 -0.3 -0.6 -0.8 -1.0 -0.1 -0.5 -0.6 1.1 -0.2 -0.2 -0.1 -0.7 -0.7 0.3 1.7 -1.0 -0.8 0.4 -0.5 0.4 1.2 0.7 -0.8 -0.3
Sensitivity / hurt feelings 0.5 0.8 3.4 -0.8 -0.3 -0.3 -1.3 -0.6 -0.5 0.2 -0.4 1.5 -1.0 -0.7 0.6 -1.2 -0.9 0.0 1.8 -0.3 0.1 -0.7 -0.2 0.6 1.8 1.1 -0.2 1.0
Frequency of depressed mood in last 2 weeks 1.1 1.6 8.6 -0.1 0.2 -0.0 -1.6 -0.5 0.6 1.2 -0.4 2.4 -0.5 -0.5 0.9 -2.4 -0.8 0.5 2.9 -0.0 1.1 0.4 -1.4 0.9 2.4 1.4 -0.4 0.9
Hearing difficulty/problems: Yes 0.7 1.0 6.9 -0.9 -0.1 -0.3 -1.2 -0.6 -0.3 0.8 -0.9 1.7 -0.6 -0.4 -0.0 -2.6 -0.8 -0.1 1.9 -0.2 0.4 -0.2 -1.6 0.6 1.6 1.0 -0.7 -0.1
Relative age of first facial hair 1.5 3.2 7.3 1.3 2.4 2.4 0.9 2.2 1.4 2.0 1.7 -0.6 1.6 1.6 2.7 -0.2 1.8 2.3 0.5 2.4 2.4 1.7 1.1 -1.4 -0.5 -0.9 2.2 2.2
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.4 0.3 0.5 0.4 0.1 0.7 1.0 1.0 0.5 0.2 0.4 0.3 0.6 -0.5 0.6 0.3 0.3 0.2 -0.1 -1.2 -0.7 -0.1 -0.0 0.0 -0.4 -0.3
Ever used hormone-replacement therapy (HRT) 0.5 0.7 3.2 0.1 -0.6 -0.8 -0.4 -0.9 0.2 0.5 -0.6 0.8 -0.3 -0.5 -1.2 -1.8 -0.6 -1.1 0.6 -0.8 -1.0 -0.1 -1.5 0.8 0.5 0.4 -1.0 -1.2
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 -0.2 -0.4 -0.4 -0.5 -0.6 -0.5 -0.7 -0.2 0.6 -0.4 -0.2 -0.1 -0.2 -0.5 0.1 0.7 -0.5 -0.7 -0.4 0.1 0.0 0.5 0.4 -0.3 0.3
Systolic blood pressure, automated reading 0.1 0.4 1.7 -0.3 -0.7 -0.8 -0.0 -0.9 -0.7 -0.3 -0.3 0.2 -0.7 -0.3 -1.3 -0.2 -0.7 -1.2 -0.4 -1.2 -0.2 -0.4 -0.5 0.1 0.4 -0.1 -0.2 -0.9
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 2.3 0.5 0.0 -0.2 -0.7 -0.2 0.7 1.1 -0.4 0.8 0.1 -0.5 -0.1 -1.4 -0.3 0.1 1.0 0.1 0.0 -0.9 -1.5 0.9 0.4 0.7 -0.9 -0.3
Angina 0.5 0.7 5.1 0.7 -0.2 -0.3 -0.6 -0.5 0.4 1.1 -0.1 0.9 -0.3 -0.5 -0.7 -2.3 -0.5 -0.1 1.1 -0.1 -0.3 -0.0 -2.0 0.6 0.8 0.4 -0.8 -1.1
Medication for hormone replacement therapy 0.4 0.4 1.5 -0.5 -0.9 -0.6 -0.0 -0.6 -0.3 -0.4 -0.8 -0.1 -0.6 -0.6 -1.1 -0.3 -0.6 -0.6 -0.9 -0.5 -0.9 0.7 -0.5 0.5 -0.1 -0.0 -0.6 -1.2
Vitamin and mineral supplements 0.3 0.3 2.1 0.4 0.7 0.8 0.1 0.5 0.4 1.1 0.4 0.1 0.3 0.4 0.7 -0.9 0.2 0.6 0.6 0.4 1.5 0.5 -0.6 -0.4 0.3 -0.3 0.3 0.1
Supplements: Zinc 0.4 0.4 1.0 -0.8 -0.6 -0.8 -0.2 -0.5 -1.0 -0.8 -0.9 0.1 -0.3 -0.6 -0.9 0.7 -0.4 -0.9 -0.6 -0.9 -0.1 0.0 0.1 0.9 -0.1 0.4 -0.7 -0.1
Medication: Co-codamol 0.5 0.6 1.5 -0.9 -0.6 -0.7 -1.1 -0.3 -0.5 -0.0 -1.1 0.8 -0.6 -1.1 -0.2 -0.1 -0.8 -1.1 0.0 -0.3 0.1 -0.9 -0.5 1.1 0.7 1.2 -0.8 0.5
Medication: Metformin 0.3 0.4 1.1 -0.4 -0.4 -0.4 -0.9 -0.4 -0.4 -0.0 -0.7 1.0 -0.3 -0.8 0.3 -0.6 -0.6 0.4 0.9 -0.3 -0.3 -0.9 -0.2 0.9 0.9 1.0 -0.6 0.8
Diabetes (father) 0.2 0.3 1.0 0.3 0.0 -0.0 0.5 0.4 0.1 0.0 -0.2 -0.6 0.8 0.0 -0.6 0.3 0.5 0.6 -1.0 -0.0 -0.2 0.4 -0.6 0.2 -0.9 -0.2 -0.5 -1.0
Diabetes (mother) 0.4 0.5 1.3 -0.7 -0.6 -0.8 -0.7 -0.5 0.3 0.5 -0.8 0.7 -0.7 -1.0 -0.6 0.5 -0.6 -1.1 0.2 -0.8 -0.2 -0.3 -0.9 1.0 0.5 0.8 -0.9 0.0
Severe depression (siblings) 0.4 0.4 1.0 -0.7 -0.7 -0.7 -0.8 -0.8 -0.7 -0.1 -0.5 1.0 -0.8 -0.6 -0.4 -0.3 -0.7 -0.3 0.8 -0.9 -0.2 -0.2 -0.3 0.4 0.9 0.8 -0.6 0.1
Pack years adult smoking proportion 1.5 2.3 5.0 1.4 1.4 1.7 1.6 1.6 1.4 0.6 1.4 -1.7 1.8 1.8 1.2 0.5 1.6 1.4 -1.1 1.2 1.8 2.2 1.8 -1.8 -1.5 -1.5 1.8 1.1
Impedance of leg (right) 0.2 1.2 4.0 0.7 0.5 1.1 1.6 0.6 -0.1 -0.4 1.5 -1.3 1.2 1.6 0.2 -0.8 1.3 2.0 -0.5 -0.1 -0.1 0.6 -0.1 -1.8 -1.2 -1.7 0.5 -1.4
Leg fat-free mass (left) 1.6 8.4 15.2 -2.9 -2.8 -3.4 -3.8 -3.2 -1.3 -1.1 -3.5 3.5 -3.5 -3.7 -1.6 0.4 -3.6 -3.6 1.9 -2.6 -2.6 -3.1 -1.2 3.7 3.2 3.9 -3.0 0.5
Trunk fat percentage 1.2 4.7 14.9 -1.0 -0.9 -1.5 -2.4 -1.8 -0.3 1.4 -1.7 3.1 -1.9 -2.1 -1.0 -3.3 -1.8 -0.9 2.8 -1.4 -1.6 -3.2 -3.9 2.5 2.6 2.3 -2.8 -1.5
Hand grip strength (right) 0.3 0.9 2.3 -1.1 -0.7 -1.0 -1.3 -0.8 -0.1 -0.9 -0.8 0.7 -1.4 -1.3 -0.1 1.3 -1.3 -1.5 0.6 -0.1 -0.3 -0.7 0.1 1.0 1.2 1.1 -0.4 0.5
Townsend deprivation index at recruitment 1.0 1.3 5.4 -0.2 -0.7 -0.9 -0.5 -0.8 -1.3 0.3 -1.0 0.9 -0.3 -1.1 -1.5 -2.0 -0.5 -0.6 0.1 -1.0 -1.0 -2.3 -2.0 1.1 0.2 0.8 -1.9 -1.7
Current tobacco smoking 1.2 1.9 3.7 1.3 1.6 1.7 1.0 1.7 1.9 1.1 1.4 -0.8 1.4 1.6 1.8 0.6 1.4 0.9 -0.0 1.6 1.7 1.3 1.4 -1.5 -0.8 -1.0 1.8 1.5
Average weekly fortified wine intake 1.0 1.2 3.3 0.9 1.2 1.4 1.1 1.3 0.7 -0.3 1.2 -1.0 1.0 1.8 1.5 -0.5 1.1 0.8 0.2 1.2 1.2 0.5 1.0 -1.8 -0.5 -1.4 1.5 0.3
Maternal smoking around birth 1.6 2.4 11.2 0.9 -0.1 -0.4 -1.5 -1.0 1.1 1.4 -0.4 2.1 -0.1 -0.8 -0.0 -3.3 -0.8 0.6 3.2 -0.3 -0.2 -1.2 -3.3 1.1 2.0 1.1 -1.8 -1.5
Fed-up feelings 0.4 0.7 2.6 0.9 0.7 1.1 0.8 0.8 0.7 0.8 0.8 -0.4 0.9 1.1 0.9 -0.6 0.9 1.6 0.1 0.3 0.3 1.2 0.7 -1.1 -0.5 -0.8 1.0 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 9.0 0.1 0.2 -0.2 -1.2 -0.5 0.9 2.0 -0.5 2.3 -0.3 -0.5 0.4 -3.0 -0.5 0.3 2.6 -0.3 0.5 -0.0 -2.3 1.0 1.9 1.2 -1.0 -0.1
Relative age voice broke 0.7 1.1 4.2 0.6 0.2 0.8 1.1 0.3 -0.0 -0.5 1.0 -1.2 1.1 1.4 0.7 -0.7 0.9 1.0 -0.5 0.8 0.1 2.1 1.7 -1.5 -0.9 -1.0 1.5 1.2
Taking other prescription medications 1.5 2.3 7.0 1.6 1.6 1.9 1.5 1.7 1.2 1.5 1.3 -1.0 1.5 1.8 1.5 -1.4 1.7 2.6 -0.3 1.7 1.3 1.8 0.5 -1.8 -1.1 -1.5 1.4 0.4
Age when periods started (menarche) 0.0 0.1 0.6 -0.5 -0.0 -0.0 0.2 0.2 -0.5 0.0 -0.0 -0.1 -0.2 -0.0 -0.4 0.3 0.0 -0.2 -0.5 -0.1 0.2 -0.5 -0.6 0.1 -0.1 -0.2 -0.2 -0.8
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 2.5 0.2 -0.1 -0.2 -0.2 -0.3 -0.3 0.4 0.1 0.3 -0.4 -0.4 -0.6 -1.4 -0.4 -0.3 0.3 -0.1 -0.5 -1.1 -1.6 0.4 0.3 0.1 -0.6 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 3.0 -0.2 -0.3 -0.4 0.0 -0.1 -1.0 -1.7 -0.4 -0.5 0.4 0.2 0.3 1.3 -0.0 -0.4 -0.8 -0.1 -0.2 0.4 1.5 -0.4 -0.3 0.1 0.1 0.5
Tinnitus: Yes, but not now, but have in the past 5.9 6.4 18.2 -3.9 -3.0 -2.9 -1.8 -2.8 -4.3 -3.5 -3.3 1.4 -2.7 -2.5 -2.6 1.0 -2.6 -2.4 -0.6 -3.4 -2.0 -1.8 -0.1 2.3 1.4 2.2 -2.5 -0.7
Qualifications: CSEs or equivalent 0.9 1.2 4.3 -1.0 -1.4 -1.0 -0.1 -0.9 -1.7 -2.1 -1.1 -0.2 -0.7 -0.8 -1.6 1.2 -0.8 -0.5 -0.8 -1.8 -1.6 -1.0 0.1 0.6 -0.1 0.1 -1.1 -1.3
Serious illness, injury or assault to yourself 0.9 1.1 2.6 -1.0 -1.1 -1.2 -0.7 -0.9 -1.2 -1.0 -1.2 0.6 -0.9 -0.9 -1.2 0.0 -1.0 -1.0 0.1 -1.6 -1.0 -1.5 -1.1 0.9 0.9 0.6 -1.4 -1.6
High blood pressure 0.6 1.5 4.2 0.9 1.2 1.3 2.0 1.3 -0.0 0.8 1.1 -1.5 1.8 1.5 0.1 -0.7 1.9 1.6 -1.4 0.6 0.7 0.6 0.2 -1.3 -2.1 -1.7 0.6 -0.7
Hayfever, allergic rhinitis or eczema 1.1 2.4 8.4 0.5 1.5 1.5 -0.1 1.1 2.2 1.3 1.3 0.7 1.1 1.2 2.9 -0.3 1.0 2.4 1.8 1.7 1.8 1.8 1.2 -1.1 0.5 0.1 1.6 2.9
Multivitamins +/- minerals 0.4 0.5 1.4 -1.0 -0.8 -0.9 -0.4 -0.6 -0.8 -1.2 -0.7 -0.0 -0.7 -0.7 -0.6 0.8 -0.6 -1.2 -0.8 -0.3 -0.9 -1.0 0.8 0.6 0.0 0.6 -0.3 0.3
Stomach or abdominal pain in last month 0.6 0.7 3.8 -0.1 0.8 0.5 -0.2 0.4 0.7 -0.2 0.6 0.1 0.1 0.7 1.7 1.0 0.1 -0.0 1.0 0.9 1.0 0.3 1.7 -0.8 0.6 -0.1 1.3 2.0
Supplements: Glucosamine 0.3 0.4 2.4 0.3 0.2 0.2 0.5 0.4 0.3 -0.5 0.5 -0.6 0.6 0.5 0.5 0.8 0.5 -0.5 -0.7 0.5 0.2 0.9 1.6 -0.7 -0.8 -0.4 0.6 0.8
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 5.4 0.9 1.9 1.7 0.5 1.5 1.9 1.5 1.4 0.1 1.0 1.4 2.2 0.3 1.1 0.8 0.9 1.7 2.3 1.7 1.1 -1.4 0.0 -0.5 1.8 2.0
Medication: Atenolol 0.3 0.4 1.0 0.3 1.0 0.7 0.8 0.7 -0.2 0.9 0.5 -0.2 0.9 0.6 -0.1 -1.0 0.9 0.5 0.0 0.3 0.7 -0.1 -0.9 -0.4 -0.6 -0.7 0.0 -0.9
Medication: Levothyroxine sodium 0.1 0.2 1.2 -0.5 -0.3 -0.4 -0.4 -0.7 -0.4 -0.7 -0.2 0.4 -0.2 -0.1 -0.3 0.2 -0.3 -0.2 0.9 -1.1 -0.4 -0.7 0.2 0.1 0.6 0.3 -0.3 0.0
Sitting height 0.8 5.9 13.0 -2.3 -2.8 -3.0 -2.7 -2.8 -1.9 -1.9 -2.9 2.1 -3.0 -3.0 -1.9 1.2 -3.0 -3.6 0.3 -2.5 -2.5 -2.6 -0.4 2.8 2.0 2.9 -2.4 0.0
Chronic bronchitis/emphysema (father) 0.5 0.6 1.5 0.8 0.9 0.9 0.3 0.7 0.7 0.8 1.0 -0.2 0.5 1.0 1.0 -0.4 0.6 0.3 0.3 1.1 1.2 0.9 0.5 -1.0 -0.1 -0.4 1.1 1.0
High blood pressure (mother) 0.8 1.2 3.4 -1.7 -1.1 -1.1 -0.2 -0.5 -1.6 -1.5 -1.5 -0.3 -0.7 -0.9 -1.6 1.8 -0.7 -1.6 -1.6 -1.3 -0.3 -0.2 0.7 0.8 -0.3 0.5 -0.7 -0.1
Body mass index (BMI) 0.3 1.3 3.6 -0.4 -0.3 -0.9 -1.5 -0.8 0.4 1.1 -1.0 1.9 -1.1 -1.3 -0.2 -1.1 -1.1 -0.9 1.5 -0.4 -0.6 -1.4 -1.6 1.6 1.5 1.5 -1.2 0.1
Impedance of leg (left) 0.1 0.6 3.5 0.4 -0.0 0.4 1.0 0.1 -0.7 -0.8 0.8 -0.9 0.6 0.8 -0.5 -0.5 0.7 1.3 -0.5 -0.5 -0.6 -0.2 -0.6 -1.1 -0.8 -1.2 -0.2 -1.9
Leg predicted mass (left) 1.7 8.8 15.4 -3.0 -2.9 -3.4 -3.8 -3.3 -1.4 -1.3 -3.6 3.5 -3.6 -3.7 -1.7 0.5 -3.6 -3.7 1.9 -2.7 -2.6 -3.2 -1.2 3.8 3.3 3.9 -3.0 0.4
Trunk fat mass 1.4 5.8 11.6 -1.8 -1.7 -2.2 -2.9 -2.4 -0.9 0.5 -2.4 3.4 -2.6 -2.7 -1.3 -2.2 -2.5 -1.8 2.5 -2.0 -2.2 -3.4 -3.1 2.9 2.9 3.0 -3.0 -0.9
Waist circumference 1.0 3.5 10.4 -1.6 -1.1 -1.6 -2.6 -1.6 -0.4 0.6 -2.0 3.2 -1.9 -2.2 -0.4 -1.0 -2.0 -1.4 2.4 -1.5 -1.0 -1.9 -1.8 2.5 2.7 2.8 -2.1 0.5
Number of incorrect matches in round 0.3 0.4 1.6 -0.3 -0.6 -0.8 -0.6 -0.9 -0.2 -1.0 -0.5 0.6 -0.8 -0.3 -0.5 0.0 -1.0 -0.8 0.9 -0.7 0.1 0.6 -0.5 0.3 1.3 0.2 -0.3 -0.8
Past tobacco smoking 0.4 0.7 4.3 0.0 0.2 0.1 1.2 0.2 -0.8 -0.9 0.5 -1.4 0.5 0.6 -0.8 2.1 0.5 -0.4 -1.5 -0.5 0.0 0.0 0.8 -0.3 -1.3 -1.0 0.4 -0.5
Alcohol usually taken with meals 2.5 4.1 7.9 0.8 2.5 2.4 1.4 2.5 1.9 0.8 2.4 -1.1 1.9 2.3 2.8 2.2 1.9 1.3 0.2 2.1 2.7 2.4 2.4 -2.0 -0.8 -1.4 2.7 2.6
Nervous feelings 0.2 0.4 2.6 -0.1 0.6 0.2 -0.4 0.3 -0.1 1.4 -0.5 0.9 0.1 -0.2 -0.1 -1.1 -0.1 0.1 0.8 0.1 1.1 0.1 -1.6 0.5 0.9 0.3 -0.5 -0.6
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.7 8.5 -1.6 -0.9 -1.1 -2.3 -1.3 -0.7 0.5 -1.6 2.9 -1.7 -1.7 -0.3 -2.0 -1.9 -1.3 2.5 -1.0 0.3 -0.4 -1.8 1.9 2.9 2.2 -1.3 0.5
Hearing difficulty/problems with background noise 1.4 2.3 12.8 0.6 1.2 0.7 -1.2 0.1 1.4 2.4 0.3 2.0 -0.0 0.5 1.5 -3.6 -0.3 0.5 3.4 1.2 1.9 1.0 -1.6 -0.2 2.2 0.6 0.4 0.9
Hair/balding pattern: Pattern 2 0.3 0.4 1.0 0.7 0.8 0.7 0.7 0.5 0.3 0.4 0.8 -0.5 0.8 0.9 0.7 0.1 0.8 0.5 -0.0 0.6 0.7 0.1 1.0 -0.8 -0.4 -0.7 1.0 0.8
Had menopause 1.4 1.7 3.8 1.7 1.7 1.5 1.1 1.8 1.1 1.9 1.2 -0.8 1.7 1.0 0.9 -1.9 1.5 1.4 -0.2 1.7 1.7 1.0 -0.9 -0.5 -0.9 -1.0 0.6 -0.2
Had other major operations 0.5 0.6 2.0 -0.6 -0.8 -1.0 -1.1 -0.8 -0.5 -0.1 -1.0 0.8 -0.7 -1.2 -0.6 -0.1 -1.0 -0.9 0.3 -0.4 -0.0 -0.2 -0.9 1.4 0.8 1.2 -0.9 -0.0
Forced vital capacity (FVC) 0.1 0.4 2.1 -0.5 -0.4 -0.3 -0.7 -0.3 -0.2 -0.1 -0.5 0.5 -0.6 -0.8 0.2 1.3 -0.6 -0.5 0.2 -0.3 -0.3 0.1 0.8 0.7 0.5 0.9 0.1 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.6 0.2 -0.0 -0.3 -0.4 -0.2 -0.3 -0.8 -0.2 0.3 0.4 0.2 0.5 0.4 -0.1 0.3 0.4 0.1 0.0 0.5 0.3 -0.2 0.3 0.3 -0.2 0.1
Ever unenthusiastic/disinterested for a whole week 2.2 2.7 5.2 -2.3 -1.5 -1.6 -2.1 -1.3 -1.4 -0.8 -2.0 1.8 -2.2 -2.1 -1.0 -0.7 -2.0 -1.2 1.0 -1.3 -1.0 -1.9 -1.4 2.2 2.0 2.0 -1.9 -0.4
Qualifications: None of the above 0.2 0.5 3.0 0.8 -0.7 -0.6 -0.1 -1.0 -0.5 -0.2 -0.2 0.5 0.1 -0.2 -1.1 -1.7 -0.3 0.3 0.4 -1.1 -1.0 -0.3 -0.9 0.1 0.1 0.1 -0.9 -1.3
Financial difficulties in last 2 years 3.2 4.2 10.0 -0.8 -1.9 -2.0 -2.5 -2.4 -0.7 -0.2 -2.0 2.8 -2.3 -1.9 -1.4 -3.2 -2.6 -1.8 2.6 -1.8 -1.1 -1.3 -2.6 2.0 3.0 2.1 -2.1 -1.0
Mouth/teeth dental problems 1.0 1.5 4.0 -1.3 -1.6 -1.3 -1.4 -1.3 -1.1 -1.2 -1.3 0.8 -1.7 -2.0 -0.9 0.5 -1.4 -0.6 -0.3 -0.6 -1.2 -1.6 0.1 2.0 0.6 1.6 -1.1 0.6
Heart attack 1.1 1.4 4.6 2.0 0.5 0.7 1.2 0.5 1.9 2.0 1.2 -0.8 0.5 0.8 -0.5 -2.1 0.9 0.8 -0.2 1.0 -0.8 -0.1 -1.8 -0.6 -1.1 -1.4 0.3 -1.9
Allergy 1.3 3.0 8.6 -0.6 -1.9 -1.9 -0.6 -1.6 -2.1 -1.1 -1.6 0.1 -1.3 -1.8 -2.9 -0.1 -1.4 -2.5 -1.2 -2.0 -2.1 -2.1 -1.8 1.8 -0.0 0.7 -2.3 -2.8
Pain all over the body in last month 0.7 0.7 2.7 -0.6 -0.8 -0.7 0.4 -0.4 -0.6 -1.2 -0.5 -0.9 -0.7 -0.4 -1.6 1.4 -0.3 -1.1 -1.3 -0.9 -0.8 -0.9 -0.0 0.3 -0.6 -0.5 -0.5 -1.5
Diabetes (self-reported) 0.4 0.7 2.5 -0.4 -0.5 -0.6 -0.6 -0.8 -0.8 0.2 -1.0 0.9 -0.3 -0.8 -0.8 -1.6 -0.6 -0.0 0.6 -0.8 -0.7 -1.1 -1.3 1.0 0.5 0.8 -1.3 -0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 2.5 0.1 0.5 0.4 -0.3 0.4 0.6 -0.1 0.1 0.4 0.9 0.2 1.0 0.9 0.2 1.2 0.5 0.4 1.3 1.6 0.4 -0.3 0.3 0.3 0.2 0.8
Medication: Ramipril 1.1 1.4 6.1 0.9 1.4 1.0 -0.0 0.7 0.6 2.1 0.5 0.7 1.3 0.7 1.4 -2.5 0.9 2.1 1.5 1.0 1.7 0.9 -0.9 -0.5 0.4 0.1 0.3 1.0
Medication: Simvastatin 0.5 0.7 4.3 1.5 0.4 0.7 0.7 0.6 0.3 1.3 0.6 -0.5 1.4 0.5 0.4 -1.3 1.0 2.1 -0.6 0.5 0.0 0.6 -0.1 -0.2 -1.1 -0.3 0.0 0.4
Fluid intelligence score 0.1 0.3 1.1 -0.8 -0.5 -0.5 -0.2 -0.2 -1.1 0.0 -0.7 0.1 -0.4 -0.7 -0.7 0.1 -0.3 -0.6 -0.8 -0.6 -0.5 -0.8 -0.4 0.7 -0.1 0.5 -0.8 -0.2
Illnesses of siblings 0.1 0.1 0.8 0.1 -0.2 -0.1 -0.4 -0.5 0.2 -0.5 -0.0 0.3 -0.4 0.2 0.6 -0.1 -0.3 -0.2 0.9 0.0 -0.4 0.2 0.4 -0.4 0.6 0.2 0.3 0.5
Neuroticism score 0.3 0.7 2.2 0.1 0.9 0.8 -0.1 0.6 0.9 0.9 0.6 0.6 0.2 0.8 1.4 -0.9 0.3 0.7 1.5 0.4 1.3 1.0 0.2 -0.9 1.0 -0.2 0.8 0.9
Weight 1.2 6.0 12.5 -2.2 -1.9 -2.5 -3.4 -2.5 -0.8 -0.2 -2.7 3.5 -2.9 -3.0 -1.0 -0.3 -2.9 -2.5 2.5 -2.0 -1.9 -2.8 -1.6 3.1 3.2 3.5 -2.6 0.5
Impedance of arm (right) 0.4 1.7 11.3 -0.7 -0.4 -0.3 -1.1 -1.1 -1.0 0.5 -0.6 1.6 -0.7 -0.5 -0.4 -3.4 -0.7 1.0 2.0 -0.8 -0.5 -1.1 -2.6 0.7 1.6 0.8 -1.4 -1.3
Arm fat percentage (right) 0.8 3.0 8.4 -0.7 -0.6 -1.1 -2.1 -1.5 0.2 1.4 -1.3 2.9 -1.7 -1.6 -0.4 -2.8 -1.6 -0.6 2.8 -0.8 -0.9 -1.9 -2.8 2.0 2.5 2.0 -1.9 -0.5
Trunk fat-free mass 1.0 5.5 12.5 -2.6 -2.5 -2.8 -2.9 -2.5 -1.2 -2.4 -2.7 2.2 -3.0 -2.8 -1.0 2.9 -3.0 -3.5 0.8 -2.0 -2.1 -1.5 1.1 2.5 2.2 3.0 -1.6 1.5
Hip circumference 1.1 4.7 8.6 -1.6 -1.9 -2.3 -2.8 -2.4 -0.8 -0.3 -2.3 2.9 -2.6 -2.7 -1.2 -1.0 -2.5 -2.1 1.9 -1.9 -2.0 -2.7 -1.9 2.9 2.6 2.8 -2.5 -0.3
Time employed in main current job 0.9 1.0 2.1 0.4 1.2 0.9 1.0 1.4 0.2 0.2 0.5 -1.0 1.4 0.9 0.9 1.4 1.2 0.7 -1.2 0.9 1.5 1.2 1.5 -0.8 -1.1 -0.7 0.9 0.9
Alcohol intake versus 10 years previously 0.5 0.7 2.2 1.0 1.0 0.8 1.0 1.0 0.4 1.5 0.8 -0.8 0.7 0.7 -0.3 -0.8 0.8 0.3 -1.0 0.9 0.9 -0.1 -1.0 -0.4 -0.9 -1.1 0.2 -1.3
Father’s age at death 0.5 0.6 2.6 -0.4 -0.9 -0.7 -0.9 -1.0 -0.7 -1.6 -0.3 0.5 -0.8 -0.4 0.4 0.7 -0.8 -0.4 0.4 -0.3 -1.1 -0.1 1.6 0.1 0.6 0.8 0.3 1.5
Worrier / anxious feelings 0.5 0.9 4.8 0.1 1.0 0.9 -0.1 0.6 0.2 1.9 0.4 1.0 0.4 0.4 0.9 -2.2 0.5 1.3 1.7 0.4 1.3 0.9 -1.2 -0.3 1.0 -0.0 0.3 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 2.6 0.4 -0.3 -0.4 -0.8 -0.8 0.6 0.4 0.0 1.2 -0.4 -0.3 0.2 -1.6 -0.3 -0.2 1.3 -0.2 -0.7 -0.6 -0.4 0.3 0.9 0.8 -0.4 0.5
Falls in the last year 0.4 0.5 2.3 0.2 0.8 0.6 -0.0 0.4 0.9 1.5 0.4 0.8 0.1 0.3 0.6 -1.4 0.2 0.4 1.1 0.4 1.1 0.2 -0.9 -0.2 0.7 -0.2 0.1 -0.2
Hair/balding pattern: Pattern 3 0.4 0.6 3.0 -1.0 -1.0 -0.6 -0.1 -0.1 -0.5 -0.6 -0.6 -0.4 -0.8 -0.8 -0.5 1.7 -0.5 -1.0 -1.7 -0.3 -1.0 -0.2 0.8 0.5 -0.5 0.4 -0.2 0.2
Number of live births 0.7 0.9 3.7 -0.0 -1.2 -1.0 -0.1 -1.2 -1.2 -1.3 -0.5 0.0 -0.3 -0.6 -1.4 -1.6 -0.4 -0.1 -0.2 -0.9 -1.9 -0.9 -0.8 0.5 -0.2 0.2 -1.2 -1.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.8 -0.6 -0.5 -0.4 -0.7 -0.5 -0.1 -0.1 -0.5 0.6 -0.6 -0.7 0.1 1.1 -0.6 -0.3 0.3 -0.5 -0.5 0.0 0.7 0.7 0.5 0.9 -0.0 1.3
Pulse rate 1.2 2.0 4.0 -1.7 -1.4 -1.5 -1.6 -1.6 -1.4 -1.1 -1.7 1.4 -1.6 -1.7 -1.0 0.2 -1.5 -0.1 0.8 -1.6 -1.6 -1.6 -0.9 1.5 1.2 1.7 -2.0 -0.6
Happiness 1.2 1.4 4.8 -1.9 -1.4 -1.2 -0.7 -0.8 -2.2 -1.4 -1.8 0.2 -1.1 -1.3 -1.2 0.8 -1.2 -1.5 -0.8 -1.4 -0.8 -0.7 -0.1 1.3 0.5 0.9 -1.1 -0.4
Noisy workplace 0.3 0.4 0.9 -0.2 -0.2 -0.5 -0.9 -0.5 0.4 -0.0 -0.5 0.7 -0.8 -0.5 -0.1 -0.6 -0.8 -0.9 0.6 0.3 0.1 -0.9 -0.8 0.5 0.9 0.5 -0.5 -0.5
Qualifications: A levels/AS levels or equivalent 0.2 0.4 2.7 -1.1 0.0 -0.0 0.1 0.6 -1.1 -0.8 -0.6 -0.5 -0.3 -0.3 -0.0 1.6 0.0 -0.2 -1.2 0.0 0.3 -0.4 0.9 0.4 -0.4 0.3 -0.1 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 3.4 0.1 -0.9 -0.6 -0.6 -0.7 -0.4 -0.1 -0.4 0.6 -0.7 -0.6 -0.9 -1.8 -0.9 -0.7 0.5 -0.5 -0.8 -0.3 -1.2 0.6 0.7 0.4 -0.8 -1.1
Mouth/teeth dental problems: Dentures 1.3 2.2 4.5 1.7 2.1 1.6 1.7 2.1 1.4 1.9 1.5 -1.3 1.7 1.7 0.6 -0.2 1.7 0.5 -0.5 1.3 1.8 0.5 -0.9 -1.6 -1.2 -2.1 1.1 -1.4
Asthma 0.2 0.4 2.2 0.5 0.4 0.7 0.4 0.5 1.5 0.4 0.7 -0.4 -0.0 0.7 0.8 -0.5 0.4 1.2 0.3 0.8 0.3 0.9 0.4 -0.7 -0.0 -0.6 1.0 0.4
Medication: Ibuprofen (e.g. Nurofen) 4.0 5.1 9.7 2.3 2.2 2.6 2.0 2.0 2.4 1.3 2.8 -1.3 2.4 3.1 2.7 -1.0 2.4 2.8 0.7 2.2 2.3 3.1 1.4 -3.1 -1.0 -2.2 2.9 1.4
Medication: Cholesterol lowering 0.2 0.4 1.4 0.9 0.0 0.2 0.8 0.1 -0.4 0.5 0.2 -0.5 0.6 0.4 -0.5 -1.2 0.6 1.1 -0.6 0.1 -0.8 0.4 -0.4 -0.2 -1.0 -0.6 -0.2 -0.7
Depression (self-reported) 0.3 0.4 2.4 0.9 0.4 0.5 0.4 0.8 1.3 1.5 0.7 -0.3 0.4 0.2 0.4 -0.9 0.6 0.4 -0.6 0.7 0.2 0.2 -0.5 -0.2 -0.4 -0.4 0.3 -0.3
Medication: Lansoprazole 0.1 0.1 0.6 -0.5 0.2 0.1 -0.3 0.3 0.1 0.3 -0.2 0.5 0.4 0.0 0.5 0.4 -0.0 -0.1 0.6 -0.1 0.6 0.8 0.0 -0.0 0.5 0.4 0.1 0.7
Prospective memory result 0.9 1.1 4.8 1.7 0.2 0.4 1.3 0.1 1.1 0.6 1.1 -1.1 0.6 0.9 -0.8 -2.0 0.7 0.1 -0.7 0.5 -0.5 0.2 -1.1 -1.0 -1.2 -1.6 0.3 -2.2
Lung cancer (father) 2.3 2.7 7.5 -1.7 -2.0 -2.0 -1.2 -2.2 -1.5 -2.7 -1.9 0.9 -2.1 -1.3 -1.9 0.6 -2.1 -1.8 0.4 -2.3 -2.0 -0.7 -0.4 0.9 1.3 0.8 -1.7 -1.9
Illnesses of mother 0.8 1.0 3.6 0.7 1.3 1.4 0.6 1.1 0.4 0.6 1.3 -0.3 0.6 1.1 1.9 -0.1 0.9 1.3 0.5 1.2 0.9 0.2 1.2 -1.1 -0.0 -0.6 1.4 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.3 -0.1 -0.2 -0.1 -0.0 -0.1 -0.1 0.2 -0.1 0.1 -0.1 -0.4 -0.2 0.6 -0.1 -0.2 -0.3 -0.3 -0.4 -0.2 0.1 0.5 -0.1 0.2 -0.1 0.3
Pulse wave Arterial Stiffness index 1.1 1.3 3.2 1.5 0.9 1.0 1.6 0.8 1.2 0.8 1.3 -1.3 1.6 1.4 0.0 -0.2 1.5 1.1 -0.8 0.5 0.4 1.4 0.4 -1.5 -1.8 -1.6 0.8 -0.6
Impedance of arm (left) 0.2 1.0 9.8 -0.2 0.3 0.4 -0.5 -0.3 -0.3 1.0 0.0 1.0 -0.0 0.1 0.3 -3.1 -0.0 1.4 1.7 -0.1 0.2 -0.8 -2.0 0.1 1.1 0.2 -0.7 -0.8
Arm fat mass (right) 1.0 4.0 9.7 -1.4 -1.2 -1.8 -2.6 -1.9 -0.2 0.8 -2.0 3.1 -2.2 -2.3 -0.8 -1.8 -2.1 -1.6 2.4 -1.4 -1.4 -2.4 -2.6 2.6 2.7 2.6 -2.3 -0.4
Trunk predicted mass 1.0 5.9 13.2 -2.7 -2.6 -2.9 -3.0 -2.6 -1.3 -2.5 -2.8 2.3 -3.1 -2.8 -1.0 3.0 -3.1 -3.6 0.8 -2.1 -2.0 -1.5 1.1 2.6 2.3 3.1 -1.6 1.6
Standing height 1.2 11.8 18.9 -4.2 -3.6 -3.9 -4.3 -3.9 -2.8 -3.0 -4.0 3.7 -4.2 -4.0 -1.9 1.6 -4.2 -4.1 2.0 -3.6 -3.1 -3.2 -0.4 3.6 3.8 4.3 -3.3 0.7
Length of working week for main job 1.2 1.3 4.0 0.2 0.3 0.6 1.7 0.7 -0.5 -0.9 0.7 -1.8 1.2 1.2 0.0 1.4 1.2 -0.1 -2.0 -0.1 0.3 1.2 1.9 -1.4 -1.8 -1.3 1.1 0.4
Exposure to tobacco smoke at home 0.2 0.3 1.2 -0.7 -0.2 -0.3 -0.7 -0.4 -0.6 0.2 -0.6 0.9 -0.4 -0.4 0.1 -0.1 -0.5 -0.3 0.5 -0.3 0.3 -0.2 0.2 0.4 0.7 0.9 -0.1 1.1
Breastfed as a baby 0.2 0.2 1.0 -0.0 -0.2 -0.4 -0.4 -0.4 -0.0 0.1 -0.2 0.4 -0.3 -0.3 -0.5 -0.9 -0.4 -0.7 0.5 0.1 -0.4 -0.5 -1.0 0.5 0.4 0.3 -0.5 -0.8
Tense / ‘highly strung’ 0.2 0.3 1.2 0.1 0.3 0.3 0.3 0.1 0.1 0.1 0.2 0.4 0.4 0.8 0.4 -0.9 0.2 0.6 0.9 -0.3 1.1 1.1 -0.3 -0.7 0.5 -0.4 0.2 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 3.0 0.7 1.4 1.1 0.0 1.2 1.4 1.4 1.0 0.5 0.6 0.7 1.7 -0.4 0.7 0.9 1.4 1.1 1.4 0.6 -0.2 -0.3 0.7 -0.1 0.9 1.0
Hair/balding pattern: Pattern 4 0.5 1.2 5.3 -0.0 -0.8 -1.0 -0.9 -1.5 -0.4 -0.1 -0.9 1.1 -0.8 -0.9 -1.4 -1.8 -1.0 -0.6 1.1 -0.7 -1.0 -0.5 -2.3 0.9 0.8 0.6 -1.3 -1.9
Birth weight of first child 0.9 1.6 3.5 -1.3 -1.3 -1.3 -1.5 -1.3 -1.5 -0.8 -1.6 1.3 -1.4 -1.7 -0.8 -0.2 -1.3 -0.7 0.9 -0.9 -1.5 -1.1 -0.6 1.9 1.2 1.8 -1.4 0.4
Peak expiratory flow (PEF) 0.2 0.5 2.8 -0.1 -0.6 -0.4 0.3 -0.6 -0.1 -1.5 0.1 -0.7 -0.1 0.3 -0.3 1.5 -0.2 -0.3 -0.4 -0.7 -1.0 0.4 1.7 -0.7 -0.4 -0.3 0.5 0.5
Pulse wave reflection index 3.8 4.7 9.9 3.1 2.1 2.3 2.6 2.2 3.1 1.5 2.9 -2.3 2.4 2.7 1.1 -0.2 2.3 0.6 -0.9 2.1 1.7 2.4 1.0 -2.6 -2.1 -2.9 2.6 -0.1
Ever highly irritable/argumentative for 2 days 0.8 1.0 3.5 0.0 0.1 -0.1 -1.2 -0.1 1.2 1.5 -0.4 1.5 -0.7 -0.8 0.4 -1.9 -0.7 -0.5 1.8 0.6 0.4 -0.1 -1.8 0.9 1.4 1.0 -0.6 0.1
Loud music exposure frequency 1.0 1.0 2.2 -0.6 -0.9 -1.1 -1.4 -1.0 0.3 -0.1 -1.1 1.4 -1.0 -0.8 -0.7 -0.3 -1.3 -0.9 1.3 -1.1 -0.6 -1.0 -1.5 0.9 1.4 1.1 -1.3 -0.7
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 7.8 -1.5 -0.4 -0.1 0.7 0.6 -2.0 -1.1 -0.9 -1.4 0.1 -0.4 -0.8 1.9 0.3 -0.3 -2.8 -0.3 0.0 -0.5 1.1 0.4 -1.4 -0.1 -0.3 0.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 1.3 -0.7 -0.5 -0.4 -0.6 -0.8 -0.7 -0.4 -0.4 0.8 -0.5 -0.1 0.1 -0.5 -0.5 0.3 0.9 -1.1 -0.5 -0.1 0.2 0.0 0.9 0.6 -0.5 0.3
Blood clot in the leg (DVT) 0.4 0.6 2.8 -0.3 0.7 0.4 0.9 0.7 -0.4 -0.7 0.6 -0.9 0.5 0.9 0.1 1.7 0.5 -0.8 -0.9 0.1 0.9 -0.6 0.9 -0.8 -0.7 -1.0 0.7 -0.2
Medication: Paracetamol 4.4 7.3 14.6 2.8 2.3 3.0 2.9 2.5 2.5 1.6 3.1 -2.3 3.3 3.4 2.6 -0.4 3.3 3.6 -0.7 2.1 2.0 3.8 2.4 -3.4 -2.4 -2.7 3.1 1.9
Headache pain in last month 2.0 3.4 6.9 1.7 1.8 2.0 2.3 2.0 1.7 0.0 2.6 -2.1 2.2 2.6 1.8 0.3 2.3 1.7 -0.9 1.6 0.9 1.1 1.4 -2.6 -2.0 -2.4 1.9 0.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.1 -0.6 -0.1 -0.1 -0.7 -0.0 0.2 -0.5 -0.2 0.3 -0.4 -0.3 0.7 0.9 -0.5 -0.5 0.4 0.2 0.8 0.3 0.6 0.2 0.8 0.6 0.3 1.0
Glaucoma (self-reported) 0.3 0.4 1.2 0.3 0.6 0.6 0.4 0.5 0.5 0.3 0.4 -0.2 0.4 0.8 0.9 -0.3 0.5 0.6 -0.1 0.9 0.8 1.1 0.7 -1.0 -0.2 -0.5 0.9 0.4
Gout (self-reported) 0.1 0.2 0.8 -0.2 -0.2 -0.1 0.4 0.0 -0.3 0.1 -0.3 -0.3 0.5 0.0 -0.4 0.3 0.4 0.3 -0.9 -0.8 -0.3 -0.1 0.4 -0.1 -0.8 0.1 -0.4 0.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 2.1 0.9 0.5 0.4 0.3 0.0 0.2 0.4 0.5 -0.0 0.5 0.4 -0.1 -1.4 0.4 0.8 0.8 -0.1 0.2 -0.4 -0.9 -0.3 0.0 -0.5 -0.1 -0.9
Medication: Amlodipine 1.3 1.8 8.7 0.3 -0.4 -0.2 1.9 0.1 -0.9 -1.5 0.1 -2.2 0.8 0.7 -1.8 0.4 0.9 0.3 -2.6 -1.1 -1.3 -0.6 -0.2 -0.9 -2.3 -1.8 -0.7 -2.9
Medication: Ventolin 100micrograms inhaler 0.8 1.0 3.4 -1.6 -1.2 -1.0 -0.6 -0.8 -1.0 -1.9 -0.9 0.0 -1.7 -0.9 -0.5 1.6 -1.1 -1.2 -0.8 -0.6 -1.1 -0.7 1.2 0.5 0.4 0.7 -0.1 0.6
Birth weight 0.3 0.7 1.7 -0.5 -0.8 -0.9 -1.0 -0.8 -0.4 -0.9 -0.9 0.8 -1.1 -1.1 -0.5 -0.2 -1.0 -0.8 0.6 -0.4 -1.2 -1.3 -0.5 0.8 0.9 0.9 -0.8 -0.3
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.5 -0.3 -0.8 -0.8 -1.3 -1.5 0.5 0.4 -0.6 1.3 -0.7 -1.0 -0.2 -1.0 -0.8 1.0 1.6 -0.7 -1.2 -0.6 -1.2 1.0 1.2 1.1 -1.2 -0.4
High blood pressure (siblings) 0.1 0.2 1.1 -0.2 -0.1 -0.1 0.3 0.2 -0.1 -0.7 0.1 -0.4 0.3 0.2 -0.2 1.1 0.1 -0.3 -0.7 -0.3 0.3 0.7 0.8 -0.1 -0.3 -0.2 0.2 0.2
Forced vital capacity (FVC), Best measure 0.0 0.1 1.1 -0.1 0.2 0.2 0.0 0.3 -0.1 0.3 0.0 -0.1 -0.0 -0.2 0.3 1.0 0.1 -0.1 -0.4 0.0 0.2 -0.0 0.6 0.1 -0.1 0.1 0.3 0.8
Body fat percentage 0.9 3.6 10.2 -0.9 -0.9 -1.4 -2.1 -1.7 -0.2 1.1 -1.5 2.8 -1.8 -1.8 -0.8 -2.8 -1.6 -0.7 2.6 -1.3 -1.6 -2.6 -3.2 2.1 2.3 2.0 -2.4 -1.2
Leg fat percentage (right) 0.4 1.3 4.6 0.0 -0.2 -0.5 -1.2 -0.9 0.8 1.6 -0.5 2.0 -0.7 -0.7 -0.1 -2.1 -0.7 0.2 2.0 -0.6 -0.8 -1.0 -2.1 1.0 1.4 1.2 -1.1 -0.3
Arm fat-free mass (right) 1.1 5.7 11.8 -2.6 -2.5 -2.9 -2.9 -2.5 -1.3 -1.9 -2.8 2.3 -2.9 -3.0 -1.4 2.2 -2.9 -3.4 0.7 -2.2 -2.2 -2.2 0.1 2.8 2.2 3.1 -2.1 0.7
Exposure to tobacco smoke outside home 0.5 0.7 3.1 -0.9 -0.3 -0.4 -1.2 -0.8 0.0 -0.1 -0.7 1.7 -0.7 -0.5 0.6 0.8 -0.8 -0.0 1.8 -0.8 0.2 0.2 0.5 0.2 1.5 1.2 -0.3 1.3
Comparative body size at age 10 0.3 0.9 4.6 -1.1 -1.0 -1.1 -0.7 -0.7 -0.7 -0.9 -1.4 0.4 -0.6 -1.1 -0.5 2.1 -0.8 -1.0 -0.6 -1.0 -0.9 -0.7 1.1 0.9 0.0 1.0 -0.6 0.9
Number of full brothers 0.8 1.0 2.4 1.1 0.4 0.8 1.1 0.9 1.1 -0.2 0.9 -1.5 0.4 0.9 0.4 0.5 0.6 -0.4 -1.0 1.2 1.2 1.5 1.2 -1.2 -1.0 -1.4 1.5 0.2
Worry too long after embarrassment 2.1 3.5 12.2 -1.7 -1.0 -1.5 -3.0 -1.6 -0.4 0.0 -1.6 3.0 -2.4 -1.9 0.2 -0.5 -2.4 -1.9 3.1 -1.0 -0.2 -1.0 -1.0 1.9 3.5 2.7 -1.2 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 3.5 0.7 0.5 0.3 -0.1 0.3 1.5 1.9 0.2 0.3 0.2 0.1 0.3 -1.5 0.3 0.2 0.5 0.6 0.3 0.1 -1.2 -0.1 0.3 -0.0 -0.0 -0.3
Wheeze or whistling in the chest in last year 0.3 0.5 2.6 -1.0 -0.0 -0.1 -1.0 -0.3 0.2 0.0 -0.3 1.5 -0.8 -0.1 1.0 0.1 -0.6 0.3 1.6 -0.5 0.3 -0.1 0.0 -0.0 1.5 0.9 -0.1 0.9
Number of children fathered 1.5 1.7 3.5 1.4 1.5 1.5 1.7 1.9 0.9 1.6 1.4 -1.7 1.4 1.0 0.5 0.7 1.6 1.1 -1.6 1.4 1.3 0.8 -0.1 -0.7 -1.8 -1.5 1.1 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 4.0 -1.0 -1.4 -1.6 -1.7 -1.7 -1.4 -0.3 -1.5 1.5 -1.7 -1.6 -1.5 -1.8 -1.6 -0.9 0.8 -1.3 -1.6 -2.0 -1.7 1.4 1.4 1.6 -1.9 -1.2
Age at first live birth 0.3 0.5 3.1 0.1 0.4 0.3 -0.7 0.5 0.2 0.6 0.3 0.3 -0.3 -0.4 1.1 -0.1 -0.3 -0.4 0.2 1.3 1.0 -0.5 0.4 0.7 0.6 0.8 0.4 1.8
Pulse wave peak to peak time 1.5 1.8 4.0 -1.8 -1.1 -1.2 -1.9 -1.0 -1.5 -1.0 -1.6 1.6 -1.8 -1.7 -0.0 0.4 -1.8 -1.4 0.9 -0.6 -0.5 -1.6 -0.2 1.7 2.0 1.9 -0.9 0.8
Health satisfaction 3.0 4.0 8.2 -2.8 -1.8 -2.1 -2.4 -1.8 -1.7 -0.6 -2.7 2.4 -1.9 -2.6 -1.3 -0.1 -2.0 -1.2 1.0 -2.2 -1.3 -1.7 -1.8 2.9 1.9 2.8 -2.8 -0.4
Shortness of breath walking on level ground 1.7 2.0 12.0 0.4 0.8 0.5 -1.3 -0.2 1.9 2.3 0.5 2.5 -0.5 -0.1 1.2 -2.5 -0.3 1.0 3.5 0.5 0.3 -0.0 -2.3 0.4 2.1 1.0 -0.5 0.2
Qualifications: College or University degree 0.1 0.4 2.0 -0.5 0.1 -0.1 -1.0 -0.2 0.4 0.0 -0.3 0.8 -0.8 -0.3 0.5 0.8 -0.7 -0.6 1.4 0.0 0.6 -0.1 0.1 0.5 1.3 0.8 0.2 1.1
Eye problems/disorders: None of the above 0.7 0.9 3.0 -1.2 -0.8 -0.9 -0.5 -0.6 -1.7 -1.2 -1.0 0.2 -1.1 -0.9 -1.1 1.1 -0.9 -1.2 -0.3 -1.3 -0.3 -1.1 -0.2 0.9 0.6 0.5 -0.8 -0.7
Mouth/teeth dental problems: Loose teeth 0.5 0.5 2.1 0.2 -0.1 -0.1 1.0 0.0 0.2 -0.1 0.3 -0.9 0.7 0.6 -0.7 1.5 0.6 -0.3 -1.1 -0.7 -0.8 0.6 0.0 -0.8 -1.2 -0.9 -0.1 -1.3
Emphysema/chronic bronchitis 0.4 0.4 1.7 0.6 0.6 0.5 0.7 0.6 0.8 1.3 0.4 -0.6 0.5 0.2 -0.1 -1.0 0.7 0.7 -0.8 0.6 0.1 -0.1 -1.0 -0.1 -0.7 -0.7 -0.0 -1.0
Medication for pain relief, constipation, heartburn 3.7 6.4 11.9 -2.9 -2.4 -2.9 -2.5 -2.3 -2.4 -1.7 -3.0 1.8 -2.9 -3.4 -2.6 1.4 -2.9 -3.4 -0.1 -2.3 -1.9 -3.4 -1.7 3.2 1.7 2.4 -3.1 -1.7
Neck or shoulder pain in last month 0.3 0.4 1.8 0.8 0.4 0.5 0.4 0.4 1.1 0.4 1.1 0.1 0.5 1.0 0.8 -1.4 0.6 0.3 0.5 0.4 0.3 0.8 0.1 -0.8 -0.1 -0.4 0.6 0.3
Medication: Blood pressure 0.2 0.4 1.7 0.3 0.5 0.5 1.1 0.7 -0.2 0.7 0.3 -0.7 0.8 0.4 -0.2 0.0 0.9 0.7 -1.0 0.2 0.0 0.2 -0.1 -0.4 -1.3 -0.8 0.0 -0.5
Angina (self-reported) 0.5 0.7 4.6 0.5 -0.1 -0.3 -0.6 -0.5 0.4 1.1 -0.2 0.9 -0.4 -0.5 -0.6 -2.1 -0.5 -0.1 1.1 -0.1 -0.3 -0.0 -2.0 0.6 0.8 0.3 -0.7 -1.1
Migraine (self-reported) 0.5 0.6 2.4 0.5 0.5 0.7 1.1 1.0 0.0 0.3 0.5 -1.4 0.1 0.6 -0.1 -0.5 0.7 -0.0 -1.5 0.9 0.4 -0.6 -0.3 -0.6 -1.1 -1.3 0.5 -1.2
Medication: Ibuprofen 2.7 3.2 7.7 2.0 1.5 1.9 1.8 1.2 2.1 1.2 2.2 -1.2 2.1 2.5 1.7 -1.5 2.1 2.8 0.5 1.4 1.3 2.4 0.6 -2.6 -1.2 -2.0 2.0 0.3
Medication: Allopurinol 0.2 0.3 0.9 0.1 0.8 0.5 0.4 0.8 0.9 1.0 0.3 -0.1 1.0 0.3 0.5 0.1 0.8 0.6 -0.2 0.3 0.8 0.2 0.1 -0.2 -0.6 -0.0 0.1 0.6
Medication: Omeprazole 0.2 0.3 1.0 -0.3 0.0 -0.2 -0.3 -0.0 -0.9 0.5 -0.6 0.5 -0.2 -0.6 -0.1 -0.3 -0.1 0.8 0.0 -0.3 0.2 -1.0 -0.7 0.9 0.2 0.5 -0.7 -0.1
Medication: Seretide 50 evohaler 0.5 0.6 2.3 -0.4 -0.9 -0.8 -0.5 -1.2 0.1 -0.8 -0.2 0.4 -1.2 -0.4 0.1 1.1 -0.8 -0.4 0.2 -0.7 -1.5 -0.4 1.5 -0.2 0.4 0.5 0.3 1.1
Mean time to correctly identify matches 0.7 1.3 4.8 1.6 1.3 1.0 0.4 0.7 1.9 2.2 1.0 0.4 1.2 1.1 1.2 -1.0 0.8 1.8 1.2 1.1 1.2 1.6 -0.4 -0.7 0.1 -0.4 0.8 0.5
Heart disease (mother) 0.3 0.3 1.8 -0.4 0.7 0.6 -0.1 0.8 -0.2 0.5 0.1 0.5 0.6 0.2 0.7 -0.5 0.4 0.6 0.8 0.2 1.3 0.6 -0.8 0.1 0.6 0.2 -0.0 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.0 5.7 -1.6 -2.0 -1.8 -0.8 -2.2 -1.7 -2.4 -1.4 0.7 -1.6 -0.9 -1.5 0.7 -1.4 -0.8 0.5 -2.3 -2.3 -0.6 0.1 0.6 0.9 0.8 -1.2 -0.8
Whole body fat mass 1.4 5.9 11.5 -1.9 -1.9 -2.4 -3.0 -2.6 -0.9 0.2 -2.5 3.4 -2.8 -2.8 -1.4 -1.8 -2.6 -2.0 2.5 -2.1 -2.3 -3.1 -2.8 2.9 2.9 2.9 -3.0 -0.9
Leg fat mass (right) 1.1 4.1 9.6 -1.4 -1.5 -2.0 -2.6 -2.2 -0.2 0.5 -2.0 3.1 -2.2 -2.3 -1.0 -1.6 -2.2 -1.5 2.4 -1.7 -1.9 -2.4 -2.3 2.5 2.5 2.6 -2.4 -0.3
Arm predicted mass (right) 1.2 6.2 13.3 -2.5 -2.6 -3.1 -3.0 -2.7 -1.3 -1.9 -2.9 2.4 -3.0 -3.1 -1.6 2.1 -3.1 -3.6 0.8 -2.4 -2.5 -2.4 -0.2 3.0 2.2 3.1 -2.4 0.3
Pulse rate, automated reading 0.3 0.9 2.7 -0.9 -0.7 -0.9 -0.6 -1.0 -1.4 -0.6 -1.2 0.7 -0.3 -0.7 -1.1 -0.5 -0.6 0.7 0.3 -1.6 -1.1 -1.2 -1.0 0.8 0.4 0.8 -1.6 -1.1
Alcohol intake frequency. 0.3 0.7 2.6 0.9 0.8 0.5 0.9 0.9 0.8 0.9 0.5 -0.9 0.3 0.4 -0.6 -0.2 0.4 -0.9 -1.2 0.9 0.4 -1.2 -1.0 -0.2 -0.9 -1.1 0.3 -1.6
Comparative height size at age 10 2.1 11.6 20.3 -3.7 -4.0 -4.2 -4.1 -4.3 -2.8 -3.0 -4.2 3.8 -3.6 -4.0 -2.5 1.5 -4.0 -3.1 1.7 -4.0 -3.4 -2.2 -0.7 3.8 3.1 4.5 -3.8 0.4
Number of full sisters 0.5 0.6 2.2 1.2 -0.2 0.2 1.0 0.2 0.2 -0.0 0.6 -1.2 0.6 0.4 -1.0 -1.5 0.5 0.4 -1.0 0.1 -0.4 -0.0 -0.4 -0.2 -1.0 -1.1 0.1 -1.3
Suffer from ‘nerves’ 0.5 0.7 2.6 0.6 0.9 0.8 0.1 0.7 1.0 1.2 0.6 0.5 0.9 0.6 1.4 -0.5 0.6 1.1 0.8 0.7 0.9 1.5 0.6 -0.5 0.3 0.1 0.8 1.6
Overall health rating 0.4 0.8 2.5 1.2 0.6 0.5 0.7 0.2 1.6 1.2 1.0 0.1 0.7 0.9 0.0 -1.4 0.9 1.5 0.7 -0.2 -0.8 -0.6 -1.3 -0.7 -0.4 -0.7 -0.3 -1.4
Chest pain or discomfort 2.0 2.9 10.2 1.7 2.6 1.9 0.4 1.8 3.1 3.2 2.2 0.5 0.9 1.4 2.3 -0.4 1.4 1.8 2.0 1.8 2.0 0.3 -1.1 -1.0 0.5 -0.8 1.2 0.5
Had major operations 1.4 1.7 4.8 -0.9 -1.5 -1.5 -1.5 -1.6 -1.0 -1.5 -1.0 1.3 -1.5 -1.3 -0.8 -0.7 -1.4 -1.3 0.9 -1.0 -1.9 -2.2 -0.7 1.1 1.2 1.4 -1.3 -0.4
Age at last live birth 1.7 2.5 5.9 -0.8 -1.1 -1.4 -2.4 -1.4 -0.7 0.2 -1.5 2.0 -1.8 -2.1 -0.5 -1.5 -2.0 -1.3 1.5 -0.2 -0.3 -2.1 -1.7 2.4 2.1 2.4 -1.6 0.3
Family relationship satisfaction 2.5 3.1 6.5 -2.5 -1.9 -1.8 -2.0 -1.6 -2.3 -1.4 -2.5 1.7 -2.0 -2.0 -1.3 -0.2 -2.2 -1.7 0.6 -1.8 -0.8 -0.7 -1.2 2.3 2.0 2.1 -2.1 -0.4
Leg pain on walking 0.8 0.9 4.5 0.3 1.0 1.1 0.3 0.9 0.5 0.7 0.9 0.1 1.1 0.9 1.5 0.4 1.0 1.5 0.7 0.4 1.0 1.2 1.2 -0.9 -0.2 -0.0 1.0 2.1
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 5.4 -0.9 -0.7 -0.4 0.4 0.0 -0.5 -1.7 -0.2 -0.8 -0.2 -0.3 0.0 2.3 -0.0 -0.5 -1.7 -0.2 -0.3 0.3 2.3 0.1 -0.9 0.0 0.4 1.1
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.5 1.4 0.7 0.8 1.4 0.9 1.5 0.2 1.1 -1.2 1.5 1.1 0.1 0.4 1.2 1.5 -1.0 0.6 0.7 1.3 0.3 -1.2 -1.6 -1.3 0.6 -0.8
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.8 0.7 1.0 0.6 0.8 0.8 0.6 0.4 0.6 -1.0 1.1 0.5 0.4 0.7 1.2 1.0 -0.7 1.2 0.3 0.1 0.4 -0.3 -1.3 -0.6 0.4 0.2
Medication: Aspirin 0.2 0.3 2.3 0.4 0.4 0.3 0.1 0.3 0.2 1.2 -0.1 0.5 0.4 0.4 -0.1 -1.5 0.2 0.5 0.7 0.0 0.4 0.4 -1.2 -0.0 0.2 -0.1 -0.3 -0.5
Supplements: Vitamin C 0.8 1.0 3.2 1.1 0.5 0.8 0.9 0.8 0.9 0.3 0.9 -1.0 1.5 0.8 0.9 0.3 1.2 1.5 -0.5 0.9 0.4 1.8 1.3 -0.6 -1.2 -0.6 1.1 1.4
Knee pain experienced in last month 0.9 1.4 8.2 1.0 0.1 0.4 1.2 0.2 0.4 -0.9 1.1 -1.1 1.0 1.3 0.8 0.8 1.1 1.0 -1.1 0.2 -0.3 1.4 2.9 -1.7 -1.5 -0.8 1.4 1.7
Hypertension (Self-reported) 0.4 1.1 3.2 0.6 0.9 1.0 1.7 1.1 -0.0 0.5 0.7 -1.3 1.5 1.3 0.2 -0.1 1.6 1.4 -1.4 0.4 0.7 0.8 0.7 -1.2 -1.8 -1.3 0.6 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.6 0.4 0.7 0.7 0.7 1.1 0.0 1.0 0.3 -0.6 1.2 0.5 0.6 0.4 1.0 1.3 -1.0 0.6 1.2 0.9 0.4 -0.3 -1.1 -0.3 0.4 0.7
Illnesses of father: Heart disease 0.4 0.5 1.6 0.6 -0.3 0.0 1.0 0.0 -0.2 -0.8 0.3 -1.2 0.9 0.6 -0.4 0.3 0.7 0.6 -1.3 -0.4 -0.3 1.3 0.3 -0.6 -1.2 -0.8 0.1 -0.9
Illnesses of siblings: Diabetes 0.5 0.6 3.1 0.5 -0.3 -0.2 1.0 -0.0 0.1 0.1 0.4 -1.0 0.2 0.1 -1.3 -0.2 0.4 -0.5 -1.8 -0.2 -0.6 -0.6 -0.7 -0.0 -1.3 -0.9 -0.2 -1.7
Smoking status: Previous 0.9 1.3 6.4 -0.2 -1.2 -1.1 -1.4 -1.3 0.4 0.3 -0.9 1.5 -1.0 -1.2 -0.4 -2.5 -1.0 -0.1 1.2 -0.4 -1.4 -0.9 -1.5 1.0 1.1 1.3 -1.4 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 5.5 -2.0 -2.2 -2.0 -1.6 -2.2 -1.4 -1.9 -1.7 1.5 -2.2 -1.6 -1.5 0.3 -1.9 -1.7 0.6 -2.3 -2.3 -2.1 -0.3 1.3 1.5 1.6 -1.8 -0.8
Whole body fat-free mass 1.3 7.2 14.4 -2.9 -2.8 -3.2 -3.4 -2.9 -1.3 -1.9 -3.2 2.9 -3.4 -3.3 -1.4 2.0 -3.4 -3.8 1.3 -2.4 -2.4 -2.3 0.0 3.2 2.8 3.5 -2.3 1.0
Leg fat-free mass (right) 1.9 10.2 18.2 -3.2 -3.1 -3.7 -4.1 -3.4 -1.7 -1.5 -3.9 3.7 -3.8 -4.1 -1.9 0.8 -3.9 -4.1 1.8 -2.9 -2.8 -3.5 -1.3 4.2 3.4 4.3 -3.4 0.4
Arm fat percentage (left) 0.6 2.4 7.1 -0.5 -0.4 -0.9 -1.9 -1.2 0.4 1.5 -1.1 2.6 -1.4 -1.4 -0.1 -2.7 -1.3 -0.4 2.6 -0.6 -0.8 -1.8 -2.5 1.8 2.2 1.8 -1.6 -0.2
Average weekly red wine intake 0.4 0.6 2.1 -0.5 -1.0 -0.9 -0.8 -1.2 0.5 -1.0 -0.2 0.8 -1.2 -0.2 -0.3 0.3 -1.1 -1.4 0.9 -0.8 -0.9 0.0 0.0 0.1 1.0 0.5 -0.2 -0.1
Handedness (chirality/laterality): Left-handed 0.6 0.8 2.5 -1.3 -0.7 -0.9 -1.1 -0.9 -0.3 -0.6 -1.3 1.2 -0.8 -0.5 -0.1 1.6 -1.1 -0.9 0.8 -1.0 -0.0 0.9 0.4 0.2 1.1 0.9 -0.4 0.5
Mood swings 1.5 2.7 7.3 1.2 1.9 2.0 1.0 1.6 1.9 2.0 1.6 -0.0 1.7 2.0 2.4 -0.8 1.6 2.7 1.2 1.0 2.0 2.4 0.6 -2.0 -0.0 -1.0 1.7 1.4
Loneliness, isolation 0.5 0.6 2.5 -1.1 -0.5 -0.5 -1.1 -0.5 -0.1 0.1 -0.8 1.2 -1.3 -0.6 -0.2 -0.5 -1.1 -1.2 1.1 -0.7 0.5 -0.3 -0.4 0.8 1.6 0.8 -0.4 0.3
Long-standing illness, disability or infirmity 2.1 3.3 8.0 2.0 2.4 2.2 1.3 2.3 2.8 2.5 2.2 -0.5 2.0 2.1 2.2 -1.5 2.1 1.9 0.6 2.2 1.6 0.7 -0.1 -1.9 -0.8 -1.4 1.6 0.5
Ever had bowel cancer screening 1.3 1.5 4.6 0.8 1.9 1.4 0.3 1.3 1.3 1.2 1.3 0.3 1.0 1.5 2.1 -0.6 0.9 1.4 1.6 1.3 2.1 0.9 0.0 -1.1 0.4 -0.4 1.0 1.2
Diabetes diagnosed by doctor 0.2 0.4 2.8 0.9 0.4 0.4 0.3 0.2 0.5 0.9 0.3 0.1 0.9 0.4 0.2 -1.7 0.6 1.1 0.5 0.2 -0.1 -0.2 -0.7 -0.1 -0.3 -0.3 -0.2 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 3.4 -0.3 -0.4 -0.2 0.8 -0.0 0.6 -0.6 0.3 -1.1 -0.1 0.4 -0.7 1.9 0.1 -1.3 -1.6 -0.3 -0.2 0.2 0.9 -0.8 -1.0 -1.0 0.5 -0.8
Friendships satisfaction 0.3 0.4 1.4 -0.2 0.9 0.6 0.6 1.2 -0.7 0.0 -0.0 -1.0 0.7 0.4 0.3 0.7 0.6 0.1 -1.0 0.8 0.9 0.1 -0.1 -0.1 -0.6 -0.6 0.1 -0.6
Qualifications: nursing, teaching 0.1 0.2 0.9 -0.6 0.0 0.0 -0.5 -0.2 -0.3 0.2 -0.3 0.7 -0.4 0.1 0.4 -0.5 -0.3 0.1 0.9 -0.1 0.4 0.8 0.0 -0.1 0.8 0.4 0.0 0.5
Commuting to job workplace: Walk 0.7 0.7 2.5 0.5 0.8 1.0 0.3 0.6 0.8 1.0 1.1 0.1 0.4 0.9 1.4 -0.7 0.7 1.0 0.7 0.9 0.4 0.1 1.1 -1.1 0.1 -0.4 1.3 1.6
Eye problems/disorders: Cataract 0.7 0.8 5.6 -0.0 0.4 0.5 -0.7 0.4 1.0 0.8 0.2 1.0 0.5 -0.2 1.8 0.0 0.3 1.7 1.0 0.9 0.2 0.7 0.9 0.2 0.4 1.0 0.4 2.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 3.0 -1.1 -0.3 -0.6 -1.3 -0.5 -0.4 -0.2 -1.0 1.6 -0.8 -0.5 0.1 0.5 -1.1 -1.3 1.4 -0.7 0.3 0.4 -0.1 0.5 1.7 1.2 -0.4 0.7
Medication for cholesterol 1.2 1.8 4.5 -1.2 -0.9 -1.1 -2.1 -1.2 -1.5 -0.9 -1.2 1.7 -1.7 -1.6 -0.0 0.0 -1.7 -1.1 1.7 -0.6 -0.4 -1.7 -0.4 1.6 2.1 2.0 -0.9 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.7 1.6 0.7 0.8 0.2 0.5 1.4 0.8 1.0 0.3 0.9 0.8 1.2 -1.2 0.6 1.6 1.4 0.6 -0.2 0.2 -0.3 -0.5 0.1 -0.1 0.3 0.5
Back pain experienced in last month 3.4 4.9 8.0 2.3 2.4 2.6 2.4 2.3 2.0 2.2 2.8 -1.6 2.5 2.8 2.2 -1.3 2.7 2.0 -0.6 2.3 2.3 2.4 1.3 -2.8 -1.9 -2.3 2.7 1.4
Mineral and other dietary supplements 0.2 0.3 1.1 -0.3 -0.3 -0.1 -0.7 -0.5 0.3 0.7 -0.4 0.6 -0.8 -0.3 -0.1 -0.9 -0.7 -0.2 1.0 -0.1 0.2 -0.1 -0.7 0.3 1.0 0.5 -0.0 0.3
Breast cancer (self-reported) 1.4 1.7 4.2 -1.3 -1.6 -1.6 -0.6 -1.1 -2.0 -1.2 -1.6 -0.0 -1.2 -1.4 -1.9 0.9 -1.3 -2.1 -1.3 -1.6 -1.0 -1.1 -0.6 1.4 0.1 0.7 -1.4 -1.2
Asthma (self-reported) 0.3 0.6 2.7 0.7 0.5 0.8 0.5 0.5 1.6 0.6 0.9 -0.6 0.1 0.9 0.9 -0.6 0.5 1.2 0.2 0.9 0.4 0.9 0.4 -1.0 -0.2 -0.8 1.1 0.3
Osteoporosis (self-reported) 0.4 0.5 2.8 0.3 0.5 0.3 -0.1 0.3 0.2 0.4 0.3 0.2 0.2 -0.0 -0.0 -1.7 0.1 0.9 0.7 0.4 0.1 -1.5 -1.7 0.3 0.4 -0.1 -0.8 -1.5
Osteoarthritis (self-reported) 0.1 0.1 0.7 -0.2 -0.4 -0.3 -0.0 -0.3 -0.2 -0.1 -0.2 0.2 0.0 -0.1 -0.1 0.1 0.1 0.5 -0.1 -0.4 -0.8 0.7 0.5 -0.1 -0.2 0.3 -0.1 0.4
Medication: Aspirin 0.3 0.4 3.9 0.4 0.1 0.0 -0.1 -0.1 0.2 1.0 -0.2 0.6 0.3 0.2 -0.4 -2.0 0.1 0.4 0.8 -0.1 -0.1 0.2 -1.6 0.2 0.3 0.0 -0.6 -0.9
Medication: Gliclazide 0.5 0.6 2.4 -0.5 0.2 0.0 -1.0 0.0 -0.1 0.3 -0.3 1.3 -0.2 -0.5 0.9 -0.5 -0.3 0.7 1.6 -0.1 0.3 -0.5 -0.3 0.9 1.2 1.2 -0.5 1.4
Illnesses of father: None of the above (group 1) 0.9 1.1 2.4 -1.5 -1.0 -1.1 -1.0 -1.1 -0.5 -0.6 -1.2 1.2 -1.4 -1.2 -0.8 0.2 -1.2 -1.3 0.7 -1.4 -0.9 -1.5 0.0 1.2 1.0 1.1 -1.0 0.1
Smoking status: Current 1.2 1.9 4.1 1.2 1.6 1.6 0.8 1.6 1.9 1.1 1.3 -0.6 1.3 1.6 2.0 0.5 1.2 0.9 0.3 1.6 1.7 1.2 1.6 -1.4 -0.4 -0.9 1.8 1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 3.4 1.6 1.5 1.6 1.3 1.5 1.4 1.9 1.6 -0.8 1.3 1.2 1.0 -0.5 1.4 1.4 -0.3 1.3 0.9 0.9 0.2 -1.0 -1.0 -1.2 1.3 0.3
Whole body water mass 1.2 7.1 14.1 -2.8 -2.7 -3.2 -3.4 -2.9 -1.3 -1.9 -3.1 2.9 -3.4 -3.3 -1.3 2.0 -3.4 -3.8 1.3 -2.3 -2.4 -2.3 0.1 3.2 2.8 3.5 -2.3 1.1
Leg predicted mass (right) 1.9 10.3 18.6 -3.2 -3.1 -3.7 -4.1 -3.4 -1.7 -1.5 -3.9 3.7 -3.9 -4.1 -1.9 0.8 -3.9 -4.0 1.9 -2.8 -2.8 -3.5 -1.4 4.2 3.5 4.3 -3.4 0.4
Arm fat mass (left) 0.8 3.1 8.4 -1.1 -0.9 -1.4 -2.4 -1.6 0.0 1.0 -1.7 2.9 -1.9 -2.0 -0.4 -1.7 -1.9 -1.2 2.5 -1.0 -1.0 -2.0 -2.2 2.3 2.5 2.3 -1.8 0.1
Number of self-reported non-cancer illnesses 0.3 0.5 2.2 0.9 0.6 0.4 0.6 0.5 0.3 1.3 0.5 -0.2 1.0 0.6 0.0 -1.5 0.9 1.0 -0.2 0.5 0.3 0.4 -0.9 -0.3 -0.7 -0.4 -0.2 -0.6
Average weekly champagne plus white wine intake 1.4 1.9 8.0 1.7 1.8 1.6 0.8 1.4 2.8 2.2 2.0 -0.5 1.0 1.4 1.3 -0.4 1.1 0.2 0.9 1.6 1.6 0.6 -0.2 -1.2 -0.3 -1.3 1.5 0.4
Miserableness 0.3 0.5 3.9 0.3 0.5 0.3 -0.4 -0.0 1.3 0.8 0.4 1.1 -0.2 0.7 0.8 -1.0 -0.1 0.3 2.0 -0.3 0.6 0.5 -0.6 -0.6 1.3 -0.0 0.3 0.1
Guilty feelings 0.1 0.1 0.7 -0.6 0.0 0.0 0.1 0.3 -0.8 0.0 -0.1 -0.0 -0.1 0.0 -0.2 -0.3 -0.0 -0.8 -0.3 -0.3 0.4 -0.3 -0.3 0.1 0.2 -0.0 -0.1 -0.3
Wears glasses or contact lenses 0.9 1.0 4.4 0.4 1.1 0.8 -0.9 0.8 0.4 1.1 0.3 1.2 0.3 -0.1 1.4 -1.4 -0.0 0.6 2.1 1.3 1.9 0.7 -0.7 0.3 1.4 0.7 0.4 1.3
Ever taken oral contraceptive pill 1.5 1.7 3.0 1.6 1.4 1.7 1.2 1.5 1.6 0.7 1.7 -1.0 1.4 1.6 1.5 -0.0 1.4 1.6 0.1 1.3 1.0 1.1 1.0 -1.7 -0.9 -1.5 1.6 0.4
Hearing aid user 1.0 1.1 4.7 1.3 1.0 1.1 0.7 0.7 1.2 0.5 1.3 -0.3 1.5 1.4 1.2 -1.4 1.4 2.2 0.8 1.0 -0.0 0.5 0.6 -1.4 -0.8 -0.6 0.7 0.8
Mother’s age at death 0.6 0.7 3.5 -0.0 -0.4 -0.3 0.8 0.2 0.3 -0.6 0.3 -1.3 -0.4 0.0 -1.0 1.0 0.1 -1.8 -1.9 0.3 -1.3 -0.7 0.0 -0.0 -1.2 -0.8 0.2 -1.2
Financial situation satisfaction 0.6 0.7 4.5 -0.1 -0.7 -0.6 -0.6 -0.5 -0.5 0.6 -0.9 0.4 -0.3 -1.0 -0.8 -1.2 -0.5 0.6 0.1 -0.4 -0.5 -0.3 -2.1 1.3 0.3 0.6 -1.4 -1.4
Tinnitus: Yes, now most or all of the time 1.5 1.8 4.6 2.1 1.6 1.3 0.2 1.1 1.8 1.6 1.6 0.3 1.5 1.4 1.7 -2.1 1.0 1.3 1.8 1.8 1.3 1.2 -0.7 -1.0 0.4 -0.5 0.9 0.3
Commuting to job workplace: Public transport 0.2 0.2 0.7 -0.3 -0.1 -0.2 -0.6 -0.2 -0.4 0.4 -0.4 0.4 -0.5 -0.6 -0.3 -0.6 -0.5 -0.6 0.6 -0.1 0.4 -0.4 -0.8 0.9 0.7 0.4 -0.4 -0.0
Eye problems/disorders: Glaucoma 0.8 0.9 2.4 0.6 0.5 0.7 1.4 0.8 0.2 -0.8 0.9 -1.4 0.5 1.1 0.4 0.3 0.9 0.3 -1.3 0.8 0.1 0.6 1.4 -1.6 -1.3 -1.4 1.2 -0.3
Medication: Blood pressure 0.6 1.1 2.9 1.3 0.7 0.6 1.3 0.6 1.2 1.7 0.6 -0.8 1.5 1.0 -0.4 -1.3 1.3 1.1 -0.8 0.2 0.1 0.7 -1.1 -0.7 -1.4 -1.2 -0.1 -1.6
Pain type(s) experienced in last month: Hip pain 0.8 1.0 4.3 1.0 1.2 1.3 0.7 0.8 0.4 0.7 1.4 -0.1 0.5 1.3 0.9 -2.1 0.9 1.4 1.0 0.8 0.9 0.5 0.1 -1.1 0.1 -1.0 1.0 0.1
Supplements: Fish oil (including cod liver oil) 0.7 1.0 2.3 1.0 1.1 1.0 1.2 1.2 0.7 0.0 1.2 -0.8 1.5 1.1 0.8 0.6 1.3 1.3 -0.6 0.7 0.9 0.7 1.1 -1.0 -1.2 -1.0 0.8 0.3
High cholesterol (Self-reported) 0.5 0.8 4.2 1.1 0.5 0.8 1.0 0.6 0.0 0.8 0.6 -0.9 1.2 0.8 0.5 -1.3 1.1 2.0 -0.8 0.7 0.1 1.5 0.1 -0.7 -1.1 -0.7 0.4 0.1
Medication: Bendroflumethiazide 0.2 0.3 1.6 0.1 -0.3 -0.1 0.6 -0.2 -0.6 -0.1 -0.1 -0.5 0.7 0.2 -0.4 -1.3 0.6 1.0 -0.7 -0.3 -0.9 0.3 -0.0 -0.3 -1.0 -0.3 -0.4 -0.4
Medication: Paracetamol 4.1 6.3 12.7 2.5 2.1 2.8 2.7 2.2 2.5 1.4 2.9 -2.1 2.9 3.3 2.5 -0.1 3.1 3.5 -0.6 1.7 1.7 3.6 2.4 -3.3 -2.3 -2.5 2.9 1.8
Medication: Lisinopril 0.1 0.2 0.7 0.3 0.5 0.4 0.2 0.6 0.8 0.7 0.4 -0.3 -0.1 0.2 0.1 0.1 0.2 0.0 0.1 0.7 -0.1 -0.6 -0.6 -0.1 0.0 -0.4 0.1 -0.8
Medication: Atorvastatin 0.3 0.3 2.2 0.5 -0.0 -0.1 0.0 -0.4 0.3 0.2 0.2 0.1 -0.4 0.2 -0.4 -0.9 -0.2 0.3 0.6 -0.0 -1.1 -0.9 -1.1 -0.2 0.1 -0.4 -0.4 -1.5
Illnesses of father: High blood pressure 0.1 0.1 0.6 0.3 -0.2 -0.1 -0.2 -0.1 0.4 0.2 -0.1 0.0 -0.2 -0.2 -0.2 -0.0 -0.3 0.1 0.1 0.1 0.3 0.4 -0.8 0.3 0.3 -0.0 -0.2 -0.7
Alcohol drinker status: Never 0.3 0.3 1.9 0.2 0.8 0.5 -0.1 0.4 0.0 1.1 0.3 0.5 0.3 0.1 0.2 -1.1 0.3 0.3 0.6 0.5 0.7 -0.9 -1.4 0.1 0.3 -0.0 -0.1 -0.4
Ever smoked 0.9 1.5 5.6 0.4 1.2 1.1 -0.8 1.3 1.5 1.6 0.4 0.8 0.4 0.2 2.4 -0.9 0.3 1.0 1.4 2.0 2.1 1.0 0.4 -0.3 1.0 0.6 1.0 2.2
Basal metabolic rate 1.3 7.3 13.0 -2.8 -2.7 -3.2 -3.5 -3.0 -1.3 -1.6 -3.2 3.1 -3.4 -3.4 -1.4 1.4 -3.4 -3.6 1.5 -2.5 -2.5 -2.7 -0.5 3.3 2.9 3.6 -2.5 0.7
Leg fat percentage (left) 0.4 1.5 5.1 -0.1 -0.4 -0.7 -1.3 -1.0 0.4 1.3 -0.8 2.0 -1.0 -1.1 -0.5 -1.8 -0.9 -0.2 1.8 -0.8 -1.1 -1.5 -2.3 1.3 1.4 1.3 -1.5 -0.7
Arm fat-free mass (left) 1.3 6.7 13.2 -2.6 -2.7 -3.1 -3.2 -2.9 -1.2 -1.8 -3.0 2.8 -3.3 -3.2 -1.6 1.8 -3.3 -3.6 1.3 -2.4 -2.4 -2.1 -0.4 3.1 2.7 3.4 -2.4 0.5
Number of operations (self-reported) 2.8 4.2 7.3 -1.5 -2.4 -2.6 -2.3 -2.5 -1.3 -1.8 -2.0 1.8 -2.5 -2.1 -1.7 -0.8 -2.6 -2.7 1.3 -1.9 -2.5 -2.3 -1.5 2.1 2.0 2.1 -2.2 -1.1
Average weekly beer plus cider intake 0.6 0.9 5.6 0.8 0.9 1.0 0.4 0.7 1.2 2.4 0.7 0.3 0.5 0.5 0.6 -2.0 0.8 1.2 0.4 0.7 0.9 0.4 -1.3 -0.4 -0.1 -0.3 0.2 -0.2
Irritability 0.2 0.3 2.0 0.6 0.3 0.4 -0.0 0.4 1.2 0.9 0.5 0.0 -0.3 0.3 0.4 -1.4 0.1 -0.4 0.2 0.9 0.3 0.1 -0.1 -0.5 0.2 -0.2 0.6 0.2
Risk taking 0.3 0.4 2.9 -0.2 -0.5 -0.5 0.4 -0.7 -0.6 -0.5 -0.4 -0.1 0.3 0.1 -1.0 -0.1 0.0 0.5 -0.4 -1.4 -0.5 -0.0 -0.8 -0.2 -0.4 -0.4 -0.9 -1.7
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.3 0.6 0.3 0.2 0.6 0.1 0.8 0.3 0.7 -0.6 0.6 0.8 -0.1 1.1 0.5 -0.0 -0.6 0.2 -0.2 0.8 0.7 -0.7 -0.8 -0.6 0.6 0.2
Fractured/broken bones in last 5 years 0.1 0.1 0.2 0.4 0.3 0.2 0.3 0.2 -0.0 0.5 0.3 0.0 0.4 0.3 -0.1 -0.2 0.3 -0.3 -0.0 -0.2 0.3 -0.4 -0.5 -0.2 -0.2 -0.3 -0.1 -0.5
Age started oral contraceptive pill 0.8 1.1 6.0 1.6 1.4 0.8 -0.1 1.0 1.3 2.5 0.6 0.3 0.6 0.1 0.6 -1.3 0.4 0.9 0.9 1.3 1.4 0.3 -1.9 0.5 0.3 -0.2 -0.0 -0.5
Diastolic blood pressure, automated reading 1.3 4.0 8.5 -1.4 -2.4 -2.4 -1.6 -2.8 -2.1 -1.6 -1.8 1.5 -2.0 -2.0 -2.5 -1.2 -2.1 -1.5 0.7 -2.9 -2.4 -2.3 -1.9 1.9 1.6 1.5 -2.5 -2.0
Ever depressed for a whole week 2.2 2.7 4.1 -1.9 -1.6 -1.7 -1.8 -1.7 -2.0 -1.1 -2.0 1.7 -1.9 -1.8 -1.3 -1.1 -1.9 -1.0 1.0 -1.8 -1.0 -1.8 -1.4 1.8 1.9 1.8 -2.0 -0.9
Unable to work because of sickness or disability 0.6 0.8 2.2 1.4 0.1 0.3 1.4 0.6 0.8 -0.4 1.0 -1.4 0.8 0.8 -0.4 0.2 0.9 0.4 -1.3 -0.1 -0.3 0.1 0.1 -0.8 -1.3 -1.4 0.3 -1.5
Commuting to job workplace: Cycle 0.7 0.9 2.1 -1.1 -0.5 -0.7 -1.3 -0.6 -0.9 -0.0 -0.9 1.1 -1.2 -1.4 0.0 -0.6 -1.1 -1.5 0.6 0.1 0.1 -1.0 -0.3 1.4 1.3 1.4 -0.4 1.1
Myopia 0.5 0.7 3.1 -0.1 0.4 0.0 -1.3 -0.1 -0.2 1.1 -0.4 1.5 -0.4 -0.5 0.7 -1.0 -0.6 0.5 1.8 0.3 1.2 0.1 -0.7 0.5 1.6 1.0 -0.1 1.0
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.1 -0.8 -1.0 -0.9 -1.4 -0.9 -0.3 -1.1 -0.8 0.8 -1.2 -1.1 0.2 1.1 -1.4 -1.2 0.7 -0.2 -0.2 0.0 0.6 0.9 1.4 1.2 -0.1 1.1
Cholesterol lowering medication 1.7 2.5 4.9 1.4 1.5 1.7 1.9 1.7 1.3 1.4 1.6 -1.5 2.2 2.0 1.3 -0.4 2.1 1.9 -1.0 1.2 1.2 1.9 0.9 -1.6 -1.9 -1.5 1.5 0.8
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 1.5 -0.2 0.3 -0.0 -0.2 0.2 -1.0 0.8 -0.4 0.6 0.0 -0.5 0.1 0.1 0.1 1.0 0.1 -0.4 0.1 -1.2 -0.6 0.9 0.2 0.5 -0.6 0.2
Pain experienced in last month 1.8 2.9 6.8 -1.6 -1.4 -1.6 -1.9 -1.5 -2.0 -0.6 -2.2 1.5 -1.8 -2.5 -1.6 0.1 -1.9 -0.6 0.9 -1.4 -1.4 -2.0 -2.1 2.6 1.5 1.8 -2.4 -1.3
Supplements: Calcium 2.0 2.2 4.1 1.8 2.0 1.8 1.1 1.7 2.0 1.3 1.8 -0.9 1.7 1.7 1.8 -0.3 1.7 1.7 0.6 2.0 1.7 1.5 0.2 -1.4 -0.6 -1.3 1.6 0.4
Basal cell carcinoma (self-reported) 1.7 2.0 5.7 1.6 1.0 1.3 2.3 1.1 0.9 0.9 1.7 -1.9 2.1 1.7 0.0 -0.5 2.0 1.6 -1.6 0.3 -0.0 0.7 0.2 -1.6 -2.4 -2.0 0.8 -0.9
Heart attack/myocardial infarction (self-reported) 1.3 1.7 5.1 2.2 0.6 0.9 1.4 0.7 2.1 2.1 1.4 -1.1 0.6 0.9 -0.5 -2.3 1.1 0.9 -0.5 1.2 -0.7 0.1 -1.8 -0.7 -1.3 -1.6 0.4 -1.9
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 3.5 -0.2 0.8 0.6 1.1 0.9 -0.4 -0.6 0.7 -1.1 0.5 1.1 0.2 1.9 0.6 -0.7 -1.2 0.2 1.1 -0.5 1.0 -1.0 -0.8 -1.3 0.9 -0.2
Heart disease (siblings) 0.8 1.0 2.9 0.3 1.0 1.0 1.0 1.4 0.8 0.2 0.8 -1.0 1.0 0.6 0.8 1.7 1.1 1.1 -1.3 1.0 1.3 0.4 1.2 -0.6 -1.3 -0.6 0.8 0.6
Alcohol drinker status: Previous 0.1 0.1 0.3 -0.0 -0.1 -0.2 -0.2 0.1 0.2 0.3 -0.6 0.1 -0.1 -0.5 -0.2 0.4 0.0 -0.4 -0.4 -0.0 -0.1 -0.4 -0.1 0.4 -0.2 0.4 -0.3 0.2
Pack years of smoking 2.1 3.0 6.5 1.7 1.7 2.0 1.9 1.8 1.5 0.9 1.7 -1.8 2.1 2.1 1.4 0.1 2.0 1.7 -1.1 1.5 2.0 2.5 1.8 -2.0 -1.7 -1.8 2.0 1.1
Impedance of whole body 0.1 0.7 5.9 -0.1 0.1 0.2 -0.1 -0.3 -0.6 0.3 0.2 0.4 0.1 0.2 -0.2 -2.4 0.1 1.3 1.1 -0.4 -0.2 -0.7 -2.0 -0.3 0.6 -0.2 -0.8 -1.7
Leg fat mass (left) 1.3 4.9 10.7 -1.7 -1.8 -2.2 -2.8 -2.4 -0.6 0.2 -2.3 3.3 -2.5 -2.6 -1.2 -1.3 -2.5 -1.7 2.4 -2.0 -2.1 -2.6 -2.3 2.7 2.7 2.9 -2.6 -0.4
Arm predicted mass (left) 1.5 7.5 15.1 -2.9 -2.9 -3.3 -3.3 -2.9 -1.4 -1.9 -3.2 2.9 -3.5 -3.4 -1.8 2.1 -3.4 -3.9 1.1 -2.6 -2.6 -2.5 -0.4 3.3 2.6 3.5 -2.6 0.4