TWAS hub - ZNF280D

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0660	0.0280	0.0013	0.001	0.036	0.032	0.039	0.012	0.23	2.7e-05	7.2e-05	1.4e-05	0.011
2	GTEx	Nerve Tibial	0.0885	0.0462	0.0050	-0.004	NA	0.013	NA	-0.004	0.99	NA	3.7e-02	NA	0.990

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hair/balding pattern: Pattern 2	4.9	6.3	12.4	0.4	-3.5
Hand grip strength (right)	4.2	11.5	21.3	-1.3	-4.6
Bilateral oophorectomy (both ovaries removed)	4.1	4.8	8.9	-3.0	-0.8
Age started oral contraceptive pill	4.0	5.0	5.3	2.2	2.3
Blood Red Count	3.6	34.4	62.7	-7.9	-2.5
Coronary Artery Disease (CAD)	3.5	4.1	4.2	-2.0	-2.0
Hearing difficulty/problems with background noise	3.5	5.6	8.6	-1.6	-2.9
Pain all over the body in last month	3.4	3.6	6.6	2.6	0.8
Tinnitus: Yes, but not now, but have in the past	3.3	3.5	4.4	2.1	1.6
Medication: Bendroflumethiazide	3.2	4.8	5.2	2.1	2.3
Qualifications: None of the above	3.0	6.4	11.3	-1.2	-3.4
Qualifications: O levels/GCSEs or equivalent	3.0	4.8	8.6	1.0	2.9
Age at last live birth	3.0	4.3	5.9	1.6	2.4
Pack years of smoking	3.0	4.4	8.2	-2.9	-0.7
Townsend deprivation index at recruitment	2.8	3.9	5.3	1.6	2.3
Knee pain experienced in last month	2.8	4.3	8.5	-2.9	-0.3
Osteoarthritis (self-reported)	2.8	3.6	3.9	-1.8	-2.0
Commuting to job workplace: Walk	2.7	2.9	4.2	2.0	1.3
Hand grip strength (left)	2.5	6.6	12.8	-0.7	-3.6
Medication: Lisinopril	2.5	3.2	4.8	-2.2	1.3
Pack years adult smoking proportion	2.4	3.6	7.0	-2.6	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	5.4	-0.5	-2.3
Irritability	2.4	4.0	7.9	-0.4	-2.8
Mean time to correctly identify matches	2.2	4.2	4.8	2.2	1.9
Neuroticism (2016)	1.9	2.8	5.1	2.3	0.7
Schizophrenia (2014)	1.9	4.2	8.5	0.0	2.9
Heart disease (mother)	1.9	2.3	4.5	-0.1	2.1
Medication: Aspirin	1.9	2.4	4.8	0.1	2.2
Average weekly spirits intake	1.8	2.2	3.2	-1.8	-1.1
Exposure to tobacco smoke at home	1.8	2.0	3.4	0.7	1.8
Age at first live birth	1.8	3.1	4.6	1.3	2.1
Breast cancer (self-reported)	1.8	2.2	3.1	1.1	1.8
Miserableness	1.8	3.2	5.2	-1.1	-2.3
Bipolar Disorder or Schizophrenia	1.7	4.2	8.2	0.4	2.9
Rheumatoid Arthritis	1.7	2.3	3.3	1.1	1.8
Hair/balding pattern: Pattern 4	1.7	4.1	8.2	2.9	0.1
Loud music exposure frequency	1.7	1.9	2.0	-1.4	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	4.0	-0.3	-2.0
Bipolar Disorder (2011)	1.6	1.5	1.6	-1.3	1.2
Medication: Co-codamol	1.6	1.8	2.9	-1.7	-0.8
Worry too long after embarrassment	1.6	2.7	3.6	1.9	-1.3
Depressed Affect (Nagel 2018)	1.5	3.2	6.0	-0.5	-2.5
Neuroticism (Nagel 2018)	1.5	3.4	5.7	1.1	-2.4
Birth weight	1.5	3.3	6.4	-0.5	-2.5
LDL Cholesterol	1.4	2.3	4.5	-2.1	-0.0
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.3	-0.3	1.8
Medication: Simvastatin	1.4	2.1	3.0	-1.7	1.1
Medication: Cholesterol lowering	1.4	2.2	2.9	-1.2	1.7
Angina (self-reported)	1.4	1.9	3.5	-0.5	1.9
Supplements: Vitamin C	1.4	1.6	1.9	-1.4	-1.2
Bipolar Disorder (2018)	1.3	2.1	4.2	-0.1	2.1
Reaction Time	1.3	2.4	2.6	1.5	1.6
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	2.9	-0.0	1.7
Medication for pain relief, constipation, heartburn	1.3	2.3	4.0	2.0	-0.8
Medication: Aspirin	1.3	1.7	3.4	-0.1	1.8
HbA1C	1.2	1.4	1.8	-1.0	-1.3
Triglycerides	1.2	1.9	3.1	-1.8	-0.8
Serious illness, injury or assault to yourself	1.2	1.4	2.8	-0.3	1.7
Waist circumference	1.2	4.3	8.6	-2.9	0.1
Falls in the last year	1.2	1.6	2.4	1.6	0.9
Qualifications: A levels/AS levels or equivalent	1.2	2.5	5.0	-0.3	2.2
Asthma	1.2	2.4	2.8	-1.7	-1.4
Number of children fathered	1.2	1.3	2.6	-1.6	-0.1
Schizophrenia (2018)	1.1	2.2	4.0	0.6	2.0
Age at First Birth	1.1	1.6	1.9	1.1	1.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.3	-0.4	-1.5
Chronotype (morning person)	1.1	2.4	4.9	-2.2	-0.1
Worrier / anxious feelings	1.1	2.0	3.6	1.9	0.7
Medication: Omeprazole	1.1	1.3	1.8	-0.9	-1.3
Asthma (self-reported)	1.1	2.2	2.2	-1.5	-1.5
High cholesterol (Self-reported)	1.1	2.0	3.0	-1.0	1.7
Pain experienced in last month	1.1	1.8	2.1	1.2	1.4
Ever had hysterectomy (womb removed)	1.0	1.2	1.9	-1.4	-0.6
Diabetes (mother)	1.0	1.2	1.9	-0.7	1.4
Medication: Atenolol	1.0	1.3	2.0	0.7	1.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.3	-1.5	0.3
Medication: Ramipril	1.0	1.3	2.4	0.5	1.5
Arm fat percentage (right)	1.0	3.9	4.2	-1.9	2.0
Blood clot in the leg (DVT)	1.0	1.3	2.3	-0.5	-1.5
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.0	-0.6	1.4
Health satisfaction	1.0	1.3	2.6	-0.1	1.6
Mood swings	1.0	1.8	2.3	1.1	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.0	1.4	-0.0
Qualifications: nursing, teaching	1.0	1.5	2.7	0.6	1.6
Angina	0.9	1.2	2.1	-0.5	1.5
Alcohol intake versus 10 years previously	0.9	1.3	2.6	-0.1	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.1	-1.5	0.4
Arm fat mass (right)	0.9	3.5	5.9	-2.4	1.1
Breastfed as a baby	0.9	1.1	1.2	-1.0	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.7	-0.4	-1.6
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.2	0.9	-1.5
Medication: Ibuprofen	0.9	1.1	1.2	-1.1	1.0
Arm fat percentage (left)	0.9	3.4	4.1	-1.7	2.0
Medication for cholesterol	0.9	1.3	2.2	1.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	3.7	-0.0	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.9	-0.6	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.1	-0.5	-1.5
Intelligence (Savage-Jansen 2018)	0.8	2.4	3.0	-1.3	-1.7
Blood Platelet Count	0.8	9.0	10.0	2.8	-3.2
Sensitivity / hurt feelings	0.8	1.4	2.2	0.7	-1.5
Supplements: Zinc	0.8	0.8	1.4	1.2	-0.5
Medication: Levothyroxine sodium	0.8	1.3	2.1	1.4	0.7
Trunk fat mass	0.8	3.3	6.2	-2.5	0.6
Had other major operations	0.8	1.0	1.9	-1.4	0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.1	0.1	1.5
Neuroticism score	0.8	1.8	3.5	0.0	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.8	-0.1	1.3
Medication: Lansoprazole	0.8	0.9	1.6	-0.4	-1.3
Headache pain in last month	0.8	1.4	2.6	-0.3	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.3	-1.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.8	-0.1	1.3
Pulse wave peak to peak time	0.8	0.9	1.7	-1.3	-0.4
Whole body fat mass	0.8	3.3	6.3	-2.5	0.6
Leg fat mass (right)	0.8	3.0	5.8	-2.4	-0.3
Number of full sisters	0.8	1.0	1.2	-0.9	1.1
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.4	-0.7	-1.2
Myopia	0.8	1.1	2.2	-0.3	1.5
Major Depression (MDD)	0.7	0.8	1.0	-1.0	-0.8
Ovarian Cancer	0.7	0.9	1.7	0.3	1.3
Lupus	0.7	1.1	2.0	0.4	-1.4
Blood White Count	0.7	4.9	8.5	-2.9	-1.2
BMI	0.7	4.0	8.0	-2.8	-0.0
Allergy or Eczema	0.7	1.8	2.6	1.0	-1.6
Neuroticism	0.7	1.8	3.4	0.4	-1.8
Number of treatments/medications taken	0.7	1.2	2.3	-0.2	1.5
Maternal smoking around birth	0.7	1.0	1.5	-1.2	-0.7
High blood pressure	0.7	1.8	2.9	-1.7	0.9
Allergy	0.7	1.5	2.3	0.8	1.5
Trunk fat-free mass	0.7	3.8	6.1	-2.5	-1.2
Noisy workplace	0.7	0.8	1.2	1.1	-0.6
Trunk predicted mass	0.7	3.9	6.3	-2.5	-1.2
Birth weight of first child	0.7	1.3	2.0	1.4	-0.8
Gout (self-reported)	0.7	0.9	1.7	0.5	1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	1.8	1.3	1.0
Leg fat percentage (right)	0.7	2.4	4.2	-2.1	-0.7
Qualifications: College or University degree	0.7	2.3	4.0	-0.7	2.0
Neck or shoulder pain in last month	0.7	0.9	1.2	-0.8	-1.1
Friendships satisfaction	0.7	0.9	1.8	0.3	1.3
Arm fat mass (left)	0.7	2.9	5.0	-2.2	1.0
Hearing aid user	0.7	0.8	1.5	1.2	-0.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	0.9	-0.8	-1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	-1.3	-0.4
Arm fat-free mass (left)	0.7	3.3	5.6	-2.4	-1.1
Number of operations (self-reported)	0.7	1.0	1.2	-1.1	-0.9
Fractured/broken bones in last 5 years	0.7	0.9	1.6	1.3	0.4
Commuting to job workplace: Cycle	0.7	0.9	1.8	0.0	1.3
Cholesterol lowering medication	0.7	1.1	1.5	-0.8	1.2
Leg fat mass (left)	0.7	2.7	5.4	-2.3	-0.1
Waist Hip Ratio (WHR)	0.6	2.8	5.2	-2.3	-0.6
Hypothyroidism (self reported)	0.6	1.4	2.3	1.5	0.8
Trunk fat percentage	0.6	2.5	3.9	-2.0	1.1
Average weekly fortified wine intake	0.6	0.7	1.1	1.0	0.5
Mouth/teeth dental problems	0.6	1.0	1.2	1.1	0.9
Weight	0.6	3.1	6.2	-2.5	-0.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.0	-0.1	-2.0
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	1.2	0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	0.1	1.2
Body fat percentage	0.6	2.4	3.8	-1.9	1.0
Arm fat-free mass (right)	0.6	3.0	3.7	-1.9	-1.5
Had major operations	0.6	0.7	1.0	1.0	0.7
Family relationship satisfaction	0.6	0.7	0.8	0.9	0.8
Medication: Blood pressure	0.6	1.2	1.6	-1.3	0.9
Alcohol drinker status: Never	0.6	0.8	1.5	-1.2	0.1
Leg fat percentage (left)	0.6	2.1	4.1	-2.0	-0.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	-0.2	-1.2
Supplements: Calcium	0.6	0.6	0.7	0.8	-0.8
Basal cell carcinoma (self-reported)	0.6	0.8	1.1	0.6	1.1
Arm predicted mass (left)	0.6	3.3	5.6	-2.4	-1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.3	-1.5	-0.4
Mean Putamen Volume	0.5	0.6	0.7	0.8	0.7
HDL Cholesterol	0.5	0.9	1.4	0.5	1.2
Cardiovascular Disease	0.5	1.6	2.8	-0.7	1.7
Respiratory disease	0.5	1.1	2.2	-1.5	-0.1
Lung FVC	0.5	2.6	4.9	2.2	-0.5
Medication for hormone replacement therapy	0.5	0.6	1.2	-1.1	-0.2
Impedance of leg (right)	0.5	2.6	5.2	-0.1	-2.3
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.9	0.3	-1.4
Supplements: Glucosamine	0.5	0.6	1.0	-1.0	-0.5
Sitting height	0.5	3.8	5.5	-1.5	-2.4
Time employed in main current job	0.5	0.6	0.6	0.8	0.7
Happiness	0.5	0.6	0.6	0.7	0.8
Mouth/teeth dental problems: Dentures	0.5	0.9	1.2	0.8	1.1
Prospective memory result	0.5	0.6	1.1	-1.1	-0.1
Illnesses of mother	0.5	0.6	0.6	0.7	-0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.2	-0.3	-1.1
Shortness of breath walking on level ground	0.5	0.5	0.9	-1.0	-0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-1.0	0.5
Illnesses of father: Heart disease	0.5	0.7	0.8	0.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.2	0.8	1.1
Whole body fat-free mass	0.5	2.6	4.9	-2.2	-0.5
Diabetes diagnosed by doctor	0.5	0.9	1.7	-1.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	-0.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	0.2	1.1
Whole body water mass	0.5	2.8	5.3	-2.3	-0.5
Mother’s age at death	0.5	0.6	0.8	-0.6	0.9
Eye problems/disorders: Glaucoma	0.5	0.6	0.7	0.7	0.8
Basal metabolic rate	0.5	3.0	5.8	-2.4	-0.4
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.3	1.5	-0.8
Heart disease (siblings)	0.5	0.6	1.1	1.0	0.3
Worry (Nagel 2018)	0.4	0.9	1.4	1.2	-0.7
Irritable Bowel Disease (IBD)	0.4	0.8	1.5	0.5	1.2
Breast Cancer	0.4	1.0	2.0	-0.1	-1.4
Crohns Disease (2012)	0.4	0.6	0.8	-0.7	0.9
Primary Biliary Cirrhosis	0.4	0.6	0.8	0.6	0.9
Height	0.4	7.8	12.3	-1.8	-3.5
Hearing difficulty/problems: Yes	0.4	0.7	1.3	-0.0	-1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.6	0.6	0.7	-0.8
Leg fat-free mass (left)	0.4	2.1	4.2	-2.0	0.2
Relative age voice broke	0.4	0.6	0.8	0.7	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.4	-0.4	1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	0.3	1.0
Body mass index (BMI)	0.4	1.9	3.3	-1.8	0.7
Impedance of leg (left)	0.4	1.9	3.8	-0.0	-1.9
Leg predicted mass (left)	0.4	2.1	4.2	-2.0	0.2
Number of incorrect matches in round	0.4	0.6	0.8	-0.9	0.6
Hip circumference	0.4	1.7	3.2	-1.8	0.5
Number of live births	0.4	0.5	0.7	0.6	-0.9
Impedance of arm (left)	0.4	1.9	3.0	0.9	1.7
Standing height	0.4	3.9	4.2	-1.9	-2.1
Peak expiratory flow (PEF)	0.4	1.0	2.0	-0.2	-1.4
Medication: Paracetamol	0.4	0.7	1.1	-1.1	0.5
Arm predicted mass (right)	0.4	1.9	2.4	-1.5	-1.2
Suffer from ‘nerves’	0.4	0.7	1.4	-1.2	-0.1
Leg fat-free mass (right)	0.4	2.2	4.2	-2.0	0.4
Average weekly red wine intake	0.4	0.6	1.1	-0.3	-1.0
Eye problems/disorders: Cataract	0.4	0.5	0.9	1.0	0.2
Medication: Gliclazide	0.4	0.5	0.7	-0.8	-0.5
Leg predicted mass (right)	0.4	2.3	4.4	-2.1	0.5
Commuting to job workplace: Public transport	0.4	0.5	0.9	-1.0	-0.2
Medication: Paracetamol	0.4	0.6	1.0	-0.3	1.0
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	0.7	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	0.6	-0.3	0.8
Smoking Status	0.3	0.6	1.2	-0.2	1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	-0.4	0.9
Fed-up feelings	0.3	0.6	0.8	0.7	-0.9
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.1	-0.9
Multivitamins +/- minerals	0.3	0.4	0.7	0.9	0.1
Nervous feelings	0.3	0.6	0.7	-0.7	-0.8
Forced vital capacity (FVC)	0.3	1.1	2.0	0.4	-1.4
Financial difficulties in last 2 years	0.3	0.4	0.7	0.8	-0.1
Diabetes (self-reported)	0.3	0.5	0.9	-0.9	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	0.8	-0.6	-0.9
Hair/balding pattern: Pattern 3	0.3	0.5	1.0	0.1	1.0
High blood pressure (siblings)	0.3	0.5	0.8	-0.4	0.9
Emphysema/chronic bronchitis	0.3	0.3	0.6	-0.8	-0.1
Medication: Blood pressure	0.3	0.6	0.6	-0.7	0.8
Migraine (self-reported)	0.3	0.4	0.7	-0.9	-0.2
Pulse rate, automated reading	0.3	1.1	1.3	-1.1	-1.0
Hypertension (Self-reported)	0.3	0.8	1.1	-0.7	1.0
Loneliness, isolation	0.3	0.4	0.8	-0.1	-0.9
Back pain experienced in last month	0.3	0.5	0.6	-0.6	-0.7
Mineral and other dietary supplements	0.3	0.4	0.7	-0.8	-0.3
Ever taken oral contraceptive pill	0.3	0.4	0.7	-0.1	-0.8
Medication: Atorvastatin	0.3	0.4	0.6	-0.5	0.7
Ever depressed for a whole week	0.3	0.4	0.4	-0.6	0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.8	0.2
Crohns Disease (2017)	0.2	0.5	1.0	-0.0	1.0
Prostate Cancer	0.2	0.3	0.5	0.7	0.1
Blood Eosinophil Count	0.2	1.8	3.6	-1.9	-0.1
Heel T-Score	0.2	1.3	2.5	0.3	1.6
Hair Pigment	0.2	4.6	9.1	3.0	0.4
Tanning	0.2	2.9	5.4	-2.3	-0.6
Systolic blood pressure, automated reading	0.2	0.5	0.9	-1.0	0.0
Severe depression (siblings)	0.2	0.2	0.4	-0.2	0.7
Current tobacco smoking	0.2	0.4	0.7	0.1	0.8
Age when periods started (menarche)	0.2	0.5	0.8	-0.5	-0.9
High blood pressure (mother)	0.2	0.3	0.5	-0.7	0.3
Past tobacco smoking	0.2	0.5	0.6	0.7	-0.6
Alcohol usually taken with meals	0.2	0.4	0.4	0.6	0.6
Heart attack	0.2	0.2	0.3	-0.6	-0.3
Fluid intelligence score	0.2	0.4	0.4	-0.6	0.6
Impedance of arm (right)	0.2	1.1	2.1	0.4	1.4
Depression (self-reported)	0.2	0.2	0.4	0.7	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.2	-0.0	-1.1
Tense / ‘highly strung’	0.2	0.3	0.5	0.7	0.4
Forced vital capacity (FVC), Best measure	0.2	0.6	0.6	0.8	-0.7
Overall health rating	0.2	0.5	0.7	0.5	0.8
Illnesses of siblings: Diabetes	0.2	0.3	0.5	-0.7	-0.2
Smoking status: Previous	0.2	0.3	0.4	-0.5	0.6
Number of self-reported non-cancer illnesses	0.2	0.4	0.4	-0.6	-0.6
Risk taking	0.2	0.2	0.4	0.3	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.7	-0.2
Alcohol drinker status: Previous	0.2	0.2	0.3	0.3	-0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.1	-0.2	-0.2
Ulcerative Colitis	0.1	0.1	0.2	0.2	0.4
Systolic Blood Pressure	0.1	0.3	0.6	-0.1	0.8
Lung FEV1/FVC ratio	0.1	0.6	1.1	-0.3	-1.1
Relative age of first facial hair	0.1	0.2	0.4	0.2	-0.6
Vitamin and mineral supplements	0.1	0.2	0.4	-0.1	0.6
Medication: Metformin	0.1	0.1	0.1	-0.4	-0.3
Diabetes (father)	0.1	0.2	0.3	0.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.4	0.1
Had menopause	0.1	0.1	0.2	-0.1	-0.4
Father’s age at death	0.1	0.1	0.2	-0.4	0.2
Pulse rate	0.1	0.2	0.4	0.6	0.1
Lung cancer (father)	0.1	0.1	0.1	0.2	-0.3
Length of working week for main job	0.1	0.1	0.1	0.4	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.1	0.5
Exposure to tobacco smoke outside home	0.1	0.2	0.2	0.4	-0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.4	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	-0.4
Medication: Allopurinol	0.1	0.1	0.1	-0.4	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.2	-0.5
Comparative height size at age 10	0.1	0.7	0.9	-1.0	-0.7
Chest pain or discomfort	0.1	0.1	0.2	-0.4	-0.4
Leg pain on walking	0.1	0.1	0.2	0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	-0.5	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.3	0.5
Ever had bowel cancer screening	0.1	0.1	0.2	-0.0	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.1	0.3	0.3
Smoking status: Current	0.1	0.2	0.3	0.1	0.5
Average weekly champagne plus white wine intake	0.1	0.2	0.3	-0.5	0.1
Guilty feelings	0.1	0.1	0.1	0.4	-0.2
Financial situation satisfaction	0.1	0.1	0.1	-0.2	0.3
Ever smoked	0.1	0.1	0.2	-0.3	0.4
Average weekly beer plus cider intake	0.1	0.2	0.2	-0.3	-0.5
Diastolic blood pressure, automated reading	0.1	0.4	0.9	-0.9	0.0
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.5	0.2
Impedance of whole body	0.1	0.3	0.6	0.8	0.1
Depression (Nagel 2018)	0.0	0.1	0.1	0.4	0.0
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	0.1	-0.4
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.2	0.3
Fasting Glucose	0.0	0.0	0.0	0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	0.1	0.3
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	0.1	-0.2
Taking other prescription medications	0.0	0.1	0.1	0.3	0.2
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	-0.3	-0.1
Illnesses of siblings	0.0	0.0	0.0	0.1	-0.2
Pulse wave reflection index	0.0	0.0	0.0	-0.0	0.0
Glaucoma (self-reported)	0.0	0.0	0.0	-0.1	0.2
Medication: Amlodipine	0.0	0.0	0.1	0.3	0.0
Comparative body size at age 10	0.0	0.1	0.2	-0.1	0.5
Number of full brothers	0.0	0.0	0.1	-0.3	-0.1
Alcohol intake frequency.	0.0	0.1	0.1	-0.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.2	0.1
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.1	0.3
Illnesses of father: None of the above (group 1)	0.0	0.1	0.1	0.3	0.1
Wears glasses or contact lenses	0.0	0.0	0.0	-0.1	0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	0.3	-0.0
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.3	0.1

Hub : Genes

ZNF280D

Models

Trait associations