Hub : Genes

ZNF333

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1100 0.0340 3.0e-04 0.021 0.022 0.028 0.030 0.032 1.0e-03 9.0e-04 2.0e-04 1.3e-04 7.6e-05
2 GTEx Adipose Subcutaneous 0.1130 0.0420 1.9e-03 0.027 NA 0.064 NA 0.057 2.6e-03 NA 5.9e-06 NA 1.8e-05
3 GTEx Artery Aorta 0.3570 0.0850 3.0e-05 0.073 NA 0.141 NA 0.163 7.9e-05 NA 3.6e-08 NA 2.6e-09
4 GTEx Breast Mammary Tissue 0.1760 0.0650 4.5e-03 0.036 NA 0.020 NA 0.031 5.7e-03 NA 3.3e-02 NA 1.0e-02
5 GTEx Breast Mammary Tissue (Female) 0.1644 0.1108 1.1e-01 -0.008 NA -0.009 NA -0.006 7.0e-01 NA 7.8e-01 NA 5.5e-01
6 GTEx Cells Transformed fibroblasts 0.2060 0.0480 4.3e-07 0.193 NA 0.175 NA 0.191 2.0e-14 NA 3.9e-13 NA 3.0e-14
7 GTEx Colon Transverse 0.2130 0.0730 2.2e-03 0.081 NA 0.107 NA 0.112 1.1e-04 NA 9.4e-06 NA 5.4e-06
8 GTEx Esophagus Muscularis 0.2400 0.0670 2.1e-04 0.066 NA 0.046 NA 0.045 7.6e-05 NA 8.6e-04 NA 9.3e-04
9 GTEx Lung 0.1898 0.0520 2.1e-04 0.104 NA 0.079 NA 0.087 2.3e-08 NA 1.3e-06 NA 3.4e-07
10 GTEx Muscle Skeletal 0.1122 0.0377 8.6e-04 0.033 NA 0.036 NA 0.023 3.2e-04 NA 1.8e-04 NA 2.2e-03
11 GTEx Pancreas 0.2320 0.0710 1.5e-03 0.159 NA 0.104 NA 0.159 3.1e-07 NA 3.9e-05 NA 3.0e-07
12 GTEx Pituitary 0.2980 0.1030 5.5e-03 0.033 NA 0.025 NA 0.040 5.2e-02 NA 7.6e-02 NA 3.6e-02
13 GTEx Skin Not Sun Exposed Suprapubic 0.1200 0.0480 6.5e-03 0.015 NA -0.004 NA 0.031 4.6e-02 NA 7.1e-01 NA 7.5e-03
14 GTEx Testis 0.2050 0.0580 1.2e-04 0.172 NA 0.195 NA 0.195 4.5e-08 NA 4.6e-09 NA 5.0e-09
15 GTEx Thyroid 0.2610 0.0620 1.9e-08 0.102 NA 0.149 NA 0.154 3.1e-08 NA 1.7e-11 NA 7.5e-12
16 GTEx Whole Blood 0.1690 0.0440 1.0e-05 0.144 NA 0.076 NA 0.130 3.4e-13 NA 1.7e-07 NA 5.2e-12
17 NTR Blood 0.0826 0.0165 3.3e-16 0.050 0.062 0.066 0.066 0.062 6.7e-16 4.0e-19 1.8e-20 2.2e-20 2.7e-19
18 ROSMAP Brain Pre-frontal Cortex 0.1079 0.0268 9.3e-07 0.101 0.061 0.112 0.095 0.108 6.0e-13 2.5e-08 3.6e-14 2.9e-12 8.7e-14
19 YFS Blood 0.2668 0.0286 0.0e+00 0.317 0.333 0.346 0.348 0.342 1.0e-106 3.6e-113 1.1e-118 2.2e-119 5.5e-117
20 TCGA Breast Invasive Carcinoma 0.0638 0.0227 7.5e-13 0.061 0.076 0.070 NA 0.066 2.0e-12 2.9e-15 4.0e-14 NA 1.9e-13
21 TCGA Cervical Squamous Cell Carcinoma 0.1150 0.0530 2.6e-03 -0.006 0.022 -0.001 NA 0.000 8.7e-01 3.0e-02 3.7e-01 NA 3.1e-01
22 TCGA Head and Neck Squamous Cell Carcinoma 0.0858 0.0424 5.4e-05 0.018 0.052 0.046 NA 0.045 3.8e-03 1.6e-06 5.7e-06 NA 8.2e-06
23 TCGA Kidney Renal Clear Cell Carcinoma 0.0769 0.0315 5.4e-06 0.069 0.054 0.058 NA 0.053 3.3e-08 1.1e-06 3.6e-07 NA 1.3e-06
24 TCGA Brain Lower Grade Glioma 0.0509 0.0238 1.2e-05 0.029 0.038 0.020 NA 0.038 2.6e-04 3.4e-05 1.9e-03 NA 3.1e-05
25 TCGA Lung Adenocarcinoma 0.0754 0.0298 4.9e-07 0.048 0.066 0.055 NA 0.060 2.5e-06 3.8e-08 4.7e-07 NA 1.5e-07
26 TCGA Lung Squamous Cell Carcinoma 0.1023 0.0552 4.5e-04 0.037 0.028 0.028 NA 0.041 4.0e-05 3.5e-04 3.4e-04 NA 1.9e-05
27 TCGA Pheochromocytoma and Paraganglioma 0.1270 0.0550 1.0e-03 0.142 0.079 0.077 NA 0.122 2.9e-06 4.6e-04 5.5e-04 NA 1.4e-05
28 TCGA Prostate Adenocarcinoma 0.1348 0.0409 1.2e-15 0.103 0.155 0.166 NA 0.166 6.7e-11 6.2e-16 5.3e-17 NA 4.6e-17
29 TCGA Stomach Adenocarcinoma 0.0590 0.0290 8.9e-04 0.050 0.034 0.046 NA 0.049 1.6e-04 1.7e-03 2.9e-04 NA 1.9e-04
30 TCGA Thyroid Carcinoma 0.0510 0.0250 4.0e-05 0.047 0.050 0.049 NA 0.050 2.1e-05 1.1e-05 1.4e-05 NA 1.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Bipolar Disorder (2018) 0.6 0.9 2.8 -1.2 -0.9 -1.7 -1.2 -1.4 -0.5 -0.4 -1.6 -0.5 -1.4 -0.3 -1.2 -1.0 -1.1 -0.7 -0.3 -0.5 -1.3 -0.4 -0.8 -0.7 -0.9 -1.1 -1.0 -0.6 -0.7 -0.1 -1.0 -0.2 -1.2
Bipolar Disorder or Schizophrenia 0.5 1.3 7.1 -0.4 -1.3 -2.0 -1.3 -2.0 -0.1 -0.6 -2.7 -0.3 -1.6 0.2 -1.8 -0.8 -1.5 -0.7 -0.1 0.3 -1.4 -0.3 -0.6 -0.3 -0.6 -0.6 -1.4 -0.9 -0.9 -0.2 -1.0 -0.2 -1.8
Depressed Affect (Nagel 2018) 0.1 0.2 0.7 0.8 -0.6 -0.9 -0.1 0.6 -0.1 -0.0 -0.8 -0.1 0.7 0.1 -0.6 -0.1 -0.2 0.1 -0.2 -0.6 0.0 -0.2 -0.3 0.5 0.5 0.1 -0.1 0.1 0.1 -0.4 -0.1 -0.2 -0.3
Depression (Nagel 2018) 1.8 2.7 7.8 -1.1 -2.2 -2.4 -1.7 -0.9 -0.6 -1.7 -1.7 -0.8 -1.7 -0.5 -2.8 -0.1 -2.5 -1.0 -0.6 1.5 -2.0 -0.6 -1.7 -0.7 -1.5 -1.0 -2.2 -1.9 -1.9 -2.0 -1.9 -0.6 -2.5
Intelligence (Savage-Jansen 2018) 0.5 1.6 3.3 1.0 1.2 0.8 1.7 0.6 1.4 0.6 1.4 1.6 1.6 1.5 1.2 0.8 0.3 -0.8 1.4 0.7 0.5 1.1 1.6 1.5 1.6 1.5 1.0 1.6 1.8 0.3 1.7 1.6 0.4
Neuroticism (Nagel 2018) 0.6 1.3 4.1 -0.9 -1.8 -2.0 -1.3 0.3 -1.3 -1.1 -1.5 -1.4 -0.7 -1.0 -1.7 -0.9 -0.5 0.5 -1.3 -0.4 -0.2 -1.3 -1.5 -0.1 -1.0 -1.2 -0.6 -1.0 -1.1 -1.5 -1.3 -1.3 -0.8
Schizophrenia (2018) 0.3 0.7 6.2 0.7 -0.9 -1.2 -0.6 -1.4 0.2 -0.5 -2.5 -0.0 -0.9 0.5 -1.3 -0.2 -1.0 -0.4 0.1 0.7 -0.7 -0.2 -0.1 0.2 -0.1 0.1 -0.9 -0.7 -0.6 -0.2 -0.5 -0.1 -1.4
Schizophrenia vs Biploar Disorder 0.6 0.8 4.1 -0.5 -0.8 -0.7 -1.1 0.0 -0.6 -1.6 -0.2 -0.6 -0.6 -0.7 -1.2 -0.5 -0.1 0.7 -0.8 1.4 0.0 -1.0 -0.9 -0.0 -1.4 -0.3 -0.7 -1.1 -1.3 -2.0 -1.0 -0.8 -0.1
Worry (Nagel 2018) 0.7 1.5 6.4 -1.2 -1.8 -2.5 -1.5 0.0 -1.1 -1.1 -1.6 -1.1 -1.0 -0.6 -2.0 -0.6 -1.3 -0.6 -1.0 0.8 -1.2 -0.9 -1.1 0.0 -1.1 -1.4 -1.2 -1.0 -0.9 -1.3 -1.4 -0.4 -1.5
Alzheimer’s Disease (in mother) 2.1 2.4 8.2 1.6 0.1 -0.6 1.7 2.2 0.4 0.9 -0.1 0.7 1.2 0.6 1.5 0.8 1.9 0.5 0.4 -1.5 2.1 -0.5 1.9 2.6 2.0 0.7 2.9 2.3 2.8 1.0 2.0 1.0 1.3
Alzheimer’s Disease (in father) 0.2 0.2 1.5 -0.2 0.1 -1.1 -0.3 -1.0 -0.3 -1.2 -0.5 -0.2 -0.2 -0.1 -0.5 0.1 -0.3 0.1 -0.2 0.0 0.2 -0.4 -0.5 -0.0 -0.7 -0.1 -0.1 -0.4 -0.4 -1.0 -0.2 -0.3 -0.5
Alzheimer’s Disease (including proxy) 0.6 0.8 4.2 0.8 -0.2 -1.1 0.7 0.9 -0.0 0.2 -0.2 0.2 0.6 0.2 0.5 0.3 1.0 0.6 -0.1 -1.4 1.6 -0.9 1.1 2.0 1.0 0.2 1.8 1.4 1.3 0.3 0.9 0.1 0.2
Crohns Disease (2017) 0.4 0.8 4.5 -0.7 -0.7 -0.9 -0.7 1.0 -0.8 -2.1 -0.3 -0.5 0.3 -0.7 -0.5 -1.2 0.2 0.9 -0.8 -1.6 0.7 -0.9 -0.3 1.1 -0.8 -0.5 0.4 0.2 -0.5 -1.9 -0.5 -0.6 0.2
Irritable Bowel Disease (IBD) 0.2 0.4 2.2 0.3 0.2 -0.2 0.2 1.4 0.4 -1.5 0.3 0.5 0.6 0.3 0.1 0.2 -0.5 -0.6 0.4 -0.6 -0.1 -0.0 0.5 1.1 -0.1 0.2 0.1 0.7 0.3 -1.0 0.2 1.1 -0.2
Ulcerative Colitis (UC) 0.6 1.0 4.2 1.0 0.6 0.2 0.6 0.6 1.4 -0.5 0.2 1.2 0.5 1.1 0.0 1.4 -1.6 -2.0 1.4 1.0 -1.3 1.1 1.0 0.7 0.5 0.6 -0.7 0.7 0.7 -0.0 0.5 2.0 -1.1
Major Depression (MDD) 2.4 2.9 7.9 2.5 1.1 1.0 1.9 1.7 2.3 -0.3 1.2 2.3 1.3 2.2 0.3 2.8 -1.3 -1.9 2.2 1.0 -0.6 1.7 2.3 2.5 1.9 2.2 -0.4 1.7 1.0 -0.2 1.3 2.0 -0.8
Reaction Time 0.3 0.7 2.3 -0.8 -0.1 -0.2 -0.9 -1.1 -0.1 0.7 -0.9 -0.5 0.1 -0.1 -0.9 -0.1 -1.1 -0.9 -0.1 0.8 -1.4 0.5 -0.5 -1.4 -1.1 -0.8 -1.5 -1.0 -1.1 0.5 -0.8 -0.0 -0.8
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.8 -0.6 0.6 0.6 0.7 -0.3 0.1 0.7 1.4 0.3 0.7 0.5 1.1 -0.0 0.7 0.1 0.2 0.5 0.4 0.5 0.3 -0.2 0.4 0.2 0.7 0.6 0.9 0.5 0.7 0.7 1.2
Breast Cancer 0.4 1.0 4.6 0.8 0.4 -0.1 0.8 1.1 0.9 1.4 -0.9 0.6 0.7 0.6 -0.1 0.3 -1.0 -2.1 1.2 0.5 -0.7 1.5 1.4 0.6 1.3 0.6 -0.5 0.9 1.0 1.9 1.0 1.5 -0.5
Ovarian Cancer 0.3 0.4 1.7 0.1 0.2 1.1 0.5 -0.0 0.1 0.6 0.1 0.1 0.2 0.1 0.8 0.1 1.3 1.2 -0.0 -1.0 1.2 -0.5 0.3 0.0 -0.1 0.2 1.0 0.3 0.1 0.7 0.4 -0.5 1.0
Prostate Cancer 1.5 2.1 4.9 -1.3 -1.4 -1.1 -1.5 -1.6 -1.9 -1.5 -1.2 -2.0 -1.5 -1.8 -0.5 -2.2 0.5 1.5 -2.0 -0.5 0.5 -1.5 -1.8 -1.6 -1.4 -1.9 0.1 -1.5 -1.2 -1.1 -1.6 -1.4 0.2
Age at First Birth 0.5 0.7 2.8 -0.7 -1.5 -1.7 -0.4 0.7 -0.9 -0.7 -1.0 -0.8 0.2 -0.4 -0.6 -1.4 0.8 0.8 -0.9 -1.6 0.9 -0.9 -0.5 0.9 0.1 -0.5 0.9 0.4 0.4 -0.7 -0.1 -0.9 0.0
Bipolar Disorder (2011) 0.5 0.5 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.6 1.5 0.5 -1.5 0.5 0.1 1.7 0.0 1.5 -1.7
Body Mass Index (BMI) (2010) 1.3 1.7 4.8 -0.6 -1.2 0.2 -0.8 0.1 -1.8 0.3 0.0 -1.7 -0.9 -2.2 0.2 -1.8 1.9 2.1 -1.9 -1.0 1.5 -1.8 -1.3 -1.2 -1.3 -1.4 1.0 -1.0 -0.5 0.0 -0.7 -1.8 1.6
Coronary Artery Disease (CAD) 0.8 0.9 4.3 -0.2 -0.1 -0.5 -0.7 -1.1 0.2 -0.2 -0.5 0.0 0.0 0.1 -1.2 0.5 -2.0 -1.6 0.4 1.5 -2.1 1.0 -0.5 -0.8 -0.8 -0.4 -1.8 -0.5 -1.0 -0.4 -0.8 0.3 -1.5
Crohns Disease (2012) 0.5 0.9 3.9 -1.2 -1.4 -1.9 -0.5 1.7 -0.7 -2.0 -0.2 -0.6 -0.2 -0.6 -1.0 -0.6 0.1 -0.2 -0.7 -0.6 0.4 -1.3 -0.6 0.9 -0.9 -0.7 0.1 -0.3 -0.1 -2.0 -0.4 0.2 0.4
Mean Putamen Volume 0.6 0.7 2.8 -0.2 -0.1 1.6 -0.5 0.2 -0.8 1.7 0.4 -1.0 0.3 -0.7 0.4 -0.7 0.9 1.1 -0.9 -0.7 0.4 -0.3 -0.5 -1.2 -0.4 -0.8 -0.1 -0.4 -1.0 1.4 -0.7 -1.3 1.1
Fasting Glucose 0.9 1.1 4.2 -0.2 -0.6 0.1 -0.1 1.2 -1.3 0.3 0.5 -1.0 0.0 -1.2 0.8 -1.1 1.6 1.9 -1.2 -1.4 2.0 -1.4 -0.1 0.9 -0.2 -0.4 1.8 0.9 0.4 0.0 0.4 -1.4 0.9
HbA1C 1.1 1.3 5.4 -0.0 -1.2 -0.5 0.7 1.9 -1.0 0.0 -0.4 -0.4 0.5 -0.5 0.9 -0.7 2.0 1.3 -0.7 -1.4 2.3 -0.9 0.4 1.6 0.5 0.0 2.3 1.1 1.1 -0.3 0.8 -1.0 1.4
HDL Cholesterol 0.5 0.9 3.2 0.7 0.7 0.3 1.1 1.0 1.2 0.2 0.5 1.2 0.6 1.2 0.6 1.0 -0.8 -1.3 1.2 0.5 -0.7 1.0 1.3 1.1 1.2 0.8 -0.1 1.0 0.9 0.5 0.8 1.8 -0.2
LDL Cholesterol 0.3 0.4 1.9 -0.2 -0.4 -0.7 -0.6 -0.3 0.2 -0.2 -0.7 -0.1 0.0 -0.3 -0.7 0.4 -1.4 -0.9 0.2 0.6 -1.4 0.5 -0.2 -0.2 -0.6 -0.5 -1.2 -0.2 -0.6 -0.5 -0.7 0.6 -1.2
Lupus 0.2 0.3 1.5 -1.0 -0.3 -0.4 -0.6 0.6 -1.0 -0.1 -0.2 -0.9 -0.3 -0.8 -0.1 -1.2 0.3 -0.1 -0.7 -0.3 -0.2 -0.1 -0.6 -0.5 -0.7 -0.9 -0.1 -0.2 -0.2 0.1 -0.3 -0.5 0.4
Neuroticism (2016) 0.8 1.2 2.9 -1.3 -1.5 -1.3 -1.5 -0.1 -1.3 -0.3 -0.5 -1.4 -1.1 -1.1 -1.7 -0.5 -0.7 0.0 -1.2 0.3 -0.8 -1.1 -1.2 -0.4 -1.1 -1.3 -1.1 -0.9 -1.3 -0.8 -1.5 -1.1 -1.0
Primary Biliary Cirrhosis 0.5 0.7 3.5 0.3 0.9 0.2 0.1 -1.3 0.5 0.4 1.0 0.5 0.5 0.6 0.1 0.7 -0.9 -1.0 0.7 1.9 -1.4 1.0 -0.5 -1.7 -0.5 -0.0 -1.1 -0.6 -0.2 0.2 0.1 0.4 -0.2
Rheumatoid Arthritis 1.1 1.5 2.8 1.3 1.6 1.7 1.5 1.3 1.2 0.7 1.0 1.3 1.0 1.1 1.6 1.1 0.4 -0.6 1.4 -0.2 0.1 1.6 1.3 0.9 1.0 1.4 0.8 1.7 1.5 0.8 1.6 1.3 0.9
Schizophrenia (2014) 0.5 1.2 5.1 -0.8 -1.0 -0.9 -1.5 -1.8 -0.6 -0.8 -1.3 -0.8 -2.2 -0.4 -1.2 -1.2 -0.9 0.4 -0.7 0.4 -0.9 -0.8 -1.0 -0.6 -1.5 -1.0 -1.1 -1.0 -1.5 -1.0 -1.4 -1.0 -0.9
Triglycerides 0.7 1.1 3.7 -1.5 -0.4 -0.4 -1.8 -0.7 -1.4 0.3 0.1 -1.6 -0.2 -1.9 -0.6 -1.3 -0.3 0.5 -1.3 -0.5 -0.4 -0.1 -1.2 -1.2 -1.6 -1.7 -1.0 -0.7 -1.5 -0.4 -1.4 -1.1 0.0
Type 2 Diabetes (T2D) (2012) 0.3 0.4 2.0 0.3 -0.6 -0.2 -0.2 0.6 -0.6 -0.1 0.1 -0.4 -0.5 -0.7 -0.1 -0.7 0.7 1.0 -0.8 -1.4 0.6 -1.1 -0.1 0.7 0.3 -0.3 0.6 0.4 -0.0 -0.2 -0.3 -0.9 0.4
Ulcerative Colitis 0.4 0.5 4.4 0.5 0.4 0.2 0.5 2.1 0.6 0.3 0.7 0.5 0.5 0.5 0.3 0.5 -0.4 -1.3 0.6 0.1 -0.4 0.2 0.8 0.8 0.7 0.1 0.2 0.6 0.9 0.6 0.4 1.5 0.1
Blood Eosinophil Count 0.9 7.0 12.7 -3.3 -3.1 -3.6 -3.4 -2.6 -2.7 -3.5 -1.8 -2.9 -2.9 -3.3 -2.8 -2.5 -0.8 0.9 -2.8 0.0 -0.8 -2.1 -3.3 -2.2 -2.7 -2.8 -1.6 -3.3 -2.6 -3.2 -3.3 -2.0 -1.4
Blood Platelet Count 0.4 5.2 15.1 -3.0 -1.1 -0.5 -2.1 0.3 -3.2 1.5 2.1 -3.2 -1.7 -3.9 0.6 -3.3 2.2 2.2 -3.2 -3.6 1.3 -2.0 -2.5 -2.7 -1.9 -3.6 0.7 -1.0 -0.8 0.7 -1.6 -2.1 2.4
Blood Red Count 0.2 2.2 9.4 -1.4 -0.2 0.3 -1.3 -0.3 -2.1 1.2 2.5 -1.9 0.5 -2.8 0.3 -2.4 1.5 1.6 -1.9 -3.1 1.3 -0.6 -0.9 -1.2 -1.1 -1.7 0.6 -0.2 -0.8 0.7 -0.8 -1.7 1.3
Blood White Count 0.2 1.6 4.5 -1.0 -1.6 -1.4 -0.1 1.6 -1.6 -0.3 0.8 -1.2 -0.1 -2.0 0.1 -1.9 2.0 1.1 -1.5 -2.1 1.8 -1.7 -0.3 0.5 0.1 -1.1 1.9 0.3 1.1 -0.2 0.2 -0.6 1.7
Heel T-Score 0.5 3.7 8.3 -2.0 -2.2 -1.4 -2.3 -2.5 -2.4 -0.7 -0.4 -2.4 -2.0 -2.0 -1.2 -1.8 0.8 1.9 -2.6 -1.2 0.2 -1.9 -2.9 -2.7 -2.1 -2.4 -0.4 -2.5 -1.8 -0.6 -2.2 -2.7 0.2
BMI 0.4 2.2 6.8 -1.5 -0.8 0.1 -2.3 -1.8 -2.0 0.7 0.7 -2.0 -1.6 -2.5 -0.0 -1.5 -0.5 0.5 -1.7 -0.4 -0.9 0.5 -1.6 -2.6 -1.9 -2.6 -1.2 -1.0 -1.7 0.5 -1.8 -0.9 0.2
Height 0.5 10.3 27.7 2.1 1.9 -0.8 1.4 -2.0 4.4 -2.0 -1.9 4.0 2.3 5.2 -2.4 4.8 -5.3 -5.2 4.4 3.8 -4.9 3.5 1.4 0.9 1.4 3.4 -4.1 -0.1 -0.4 -1.7 0.6 3.0 -4.6
Waist Hip Ratio (WHR) 0.5 2.1 5.6 -1.4 -0.9 -0.2 -1.9 -0.5 -2.0 -0.7 0.3 -2.1 -1.7 -2.2 -0.5 -2.4 0.4 1.5 -1.9 -1.1 0.4 -1.1 -1.8 -1.7 -1.9 -1.9 -0.4 -1.4 -1.8 -0.8 -1.6 -1.9 0.5
Systolic Blood Pressure 0.2 1.1 5.3 0.7 -0.7 -1.8 0.4 -0.4 0.7 -2.2 -1.8 0.7 -0.2 0.3 -0.9 1.0 -1.3 -1.1 0.7 0.5 -0.2 -0.2 0.6 1.7 -0.3 0.9 0.2 0.3 0.4 -2.3 0.5 0.7 -1.6
Smoking Status 1.6 3.8 9.7 -1.9 -1.6 -1.4 -1.3 1.4 -3.1 -0.2 0.8 -2.8 -1.1 -3.1 0.3 -3.0 2.4 2.2 -2.9 -2.0 1.9 -2.2 -2.2 -1.6 -1.3 -2.7 1.6 -1.2 -0.2 -0.2 -1.0 -2.0 2.6
Allergy or Eczema 0.2 0.5 4.0 0.3 -0.6 -0.6 0.1 0.2 0.2 0.5 -1.0 0.5 0.4 0.4 -0.6 0.0 -0.3 -0.0 0.2 -1.5 0.4 -0.2 1.0 2.0 1.2 0.6 0.3 1.0 0.3 0.4 0.2 -0.2 -1.1
Cardiovascular Disease 0.6 1.9 5.9 -0.9 -1.8 -1.8 -1.8 -2.4 -0.9 -1.5 -1.8 -0.8 -1.4 -0.8 -2.2 -0.4 -1.3 -0.2 -0.8 1.0 -1.3 -0.5 -1.4 -1.2 -1.4 -1.1 -1.5 -1.7 -1.4 -1.3 -1.7 -0.7 -1.9
Hypothyroidism (self reported) 1.8 4.1 9.6 2.4 0.7 -0.8 1.7 -0.9 3.1 -0.9 -0.6 3.1 1.7 2.9 -0.8 3.0 -2.2 -2.9 3.0 2.7 -1.9 1.9 1.7 1.5 1.8 2.8 -1.2 0.6 1.1 -0.5 1.3 2.6 -2.4
Respiratory disease 0.5 1.1 7.9 0.4 0.3 0.2 -0.0 -1.4 1.0 -0.2 0.2 1.1 0.6 0.6 -1.1 0.5 -1.3 -1.5 0.9 2.8 -1.7 1.2 -0.1 -1.3 0.1 0.8 -1.9 -1.5 -0.9 0.5 -0.4 0.6 -0.8
Type 2 Diabetes (T2D) (2018) 0.2 0.5 3.3 0.1 0.7 1.5 -0.1 -0.1 -0.3 1.0 1.0 -0.4 0.2 -0.5 0.8 0.1 -0.1 -0.2 0.0 1.1 -0.4 0.9 -0.5 -1.8 -0.9 -0.5 -0.2 -0.3 -0.3 0.6 0.0 -0.1 0.7
Lung FEV1/FVC ratio 0.1 0.6 1.7 1.0 0.7 0.0 0.1 -1.1 0.8 -0.8 -0.5 0.9 -0.5 0.4 0.0 1.2 -1.2 -0.9 0.9 0.8 -1.2 0.7 0.3 0.2 -0.4 0.5 -0.5 0.2 0.3 -0.7 0.2 1.2 -1.3
Lung FVC 0.7 3.4 9.1 -2.1 -2.1 -0.1 -1.4 0.8 -2.6 0.1 1.0 -2.4 -1.2 -1.8 -0.3 -2.9 2.1 3.0 -2.7 -3.0 2.4 -2.8 -1.3 0.0 -1.3 -1.7 1.4 -0.5 -1.2 -0.5 -1.2 -3.0 1.3
Neuroticism 1.0 2.5 8.1 -1.1 -2.4 -2.7 -1.9 -0.6 -1.0 -1.8 -2.2 -1.1 -1.4 -0.7 -2.8 -0.3 -1.7 -0.2 -1.1 0.4 -1.4 -1.1 -1.4 0.2 -1.2 -1.1 -1.8 -1.4 -1.8 -2.1 -2.0 -1.1 -2.2
Chronotype (morning person) 1.5 3.5 10.9 -1.7 -0.7 1.0 -0.2 0.8 -2.3 1.4 1.9 -2.1 -0.7 -2.4 1.6 -2.6 3.3 3.1 -2.3 -2.7 3.1 -1.9 -0.5 -0.3 -0.5 -1.5 2.5 0.1 0.2 1.0 -0.2 -1.7 3.0
Hair Pigment 0.0 0.5 3.0 -0.1 -0.9 -1.1 -0.2 -0.0 0.1 -0.5 -1.7 -0.2 -1.3 -0.4 -0.6 -0.2 -0.9 -1.1 0.2 0.9 -0.7 -0.7 0.3 0.6 -0.4 -0.5 -0.2 -0.1 0.4 -0.4 -0.1 1.2 -1.3
Tanning 0.0 0.3 1.4 -0.1 -0.6 0.1 -0.4 -0.7 0.1 -1.2 -0.1 0.2 -0.5 0.1 -1.0 -0.1 -0.3 0.4 -0.1 -0.1 0.0 -0.6 -0.1 0.5 0.1 0.4 -0.4 -0.5 -0.8 -1.1 -0.6 -0.7 -0.9
Hand grip strength (left) 1.2 3.1 7.6 2.0 1.3 -0.2 2.1 0.5 2.7 -0.8 0.0 2.7 2.0 2.8 -0.3 2.0 -1.4 -2.2 2.7 2.0 -1.1 2.0 1.9 1.9 2.1 2.8 -0.6 1.0 1.2 -0.0 1.7 1.9 -1.1
Number of treatments/medications taken 0.9 1.6 5.5 -0.3 -1.0 -1.2 -1.0 -1.7 0.1 -1.0 -1.5 0.1 -0.6 0.4 -1.7 -0.0 -1.7 -1.2 0.0 2.4 -2.2 -0.0 -1.3 -1.5 -0.9 -0.6 -1.9 -1.8 -1.1 -1.0 -1.5 0.2 -1.7
Average weekly spirits intake 1.7 2.1 5.6 1.5 1.2 0.6 1.9 0.4 2.0 0.6 0.8 2.2 2.2 2.4 0.5 1.9 -0.5 -1.4 2.1 1.1 0.0 1.3 1.7 1.5 1.6 2.2 0.4 1.4 1.4 0.6 1.9 1.1 -0.6
Sensitivity / hurt feelings 1.6 2.8 6.0 -1.4 -2.4 -2.2 -2.1 -0.9 -1.5 -1.4 -2.1 -1.7 -2.0 -1.3 -2.4 -1.0 -1.2 0.1 -1.5 0.2 -1.1 -1.2 -2.1 -1.1 -1.8 -1.6 -1.6 -1.8 -2.1 -1.5 -2.1 -2.0 -1.5
Frequency of depressed mood in last 2 weeks 0.8 1.0 3.2 -0.8 -1.0 -1.5 -1.2 -0.8 -0.2 -0.9 0.2 -0.4 -0.9 0.0 -1.7 0.0 -1.7 -0.9 -0.3 0.3 -1.7 -0.1 -1.1 -0.7 -0.8 -0.8 -1.8 -0.9 -1.2 -1.4 -1.2 -0.2 -1.6
Hearing difficulty/problems: Yes 0.6 0.9 4.9 -0.3 -0.3 0.7 -1.0 0.4 -1.2 0.6 -0.1 -1.3 -0.6 -1.4 0.2 -1.1 0.8 1.4 -1.1 -2.2 0.7 -0.3 -0.6 -0.5 -1.1 -1.0 0.1 -0.0 -1.0 0.4 -0.6 -1.6 0.8
Relative age of first facial hair 0.5 1.1 6.7 -0.3 -1.1 -0.2 -0.9 0.1 -1.2 -0.1 0.3 -0.9 -0.4 -1.6 -0.5 -1.6 0.9 1.8 -1.3 -2.6 1.1 -1.4 -0.7 0.1 -0.5 -0.7 0.6 -0.3 -0.9 -0.3 -0.8 -2.0 0.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.0 0.7 0.8 0.9 0.4 -0.4 0.6 1.0 0.3 0.6 0.2 0.9 0.7 0.4 -0.1 -0.4 0.6 0.3 -0.6 0.9 0.5 -0.3 0.5 0.3 -0.0 0.6 0.5 0.9 0.4 0.8 0.4
Ever used hormone-replacement therapy (HRT) 1.2 1.5 6.1 -1.5 0.1 -0.0 -1.7 -1.3 -0.5 0.1 -1.4 -0.8 -0.9 -0.7 -1.2 -0.0 -1.9 -0.7 -0.4 0.3 -2.2 0.7 -0.9 -1.5 -1.7 -1.4 -2.5 -0.8 -2.1 -0.4 -1.6 -0.2 -1.2
Ever had hysterectomy (womb removed) 0.7 0.8 4.9 -0.6 -0.8 -1.2 -0.4 1.3 -1.0 -0.9 0.4 -0.7 0.8 -0.7 -0.4 -0.8 0.6 0.8 -0.9 -2.2 1.2 -1.2 0.0 1.4 -0.3 -0.5 0.9 0.7 -0.1 -1.1 0.0 -0.8 0.2
Systolic blood pressure, automated reading 0.9 2.6 6.8 1.9 1.1 -0.8 1.5 0.4 2.1 -1.5 -1.0 2.0 1.4 1.5 0.0 2.1 -1.8 -1.9 2.2 0.6 -0.8 1.5 2.0 2.6 1.2 2.1 -0.1 1.7 1.3 -1.6 1.5 2.4 -1.6
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.3 -0.2 -0.2 0.3 -1.0 -0.6 -0.5 -0.6 -0.9 -0.8 -1.2 -0.8 -0.9 -0.5 -0.4 -0.1 -0.5 1.4 -0.7 -1.0 -0.7 -1.0 -1.5 -0.7 -1.0 -1.3 -1.2 -0.6 -1.1 -0.2 -0.2
Angina 0.6 0.7 1.8 -0.6 -1.3 -1.0 -0.7 0.1 -1.2 -0.4 -1.3 -1.2 -1.0 -1.3 -0.1 -1.1 1.0 0.8 -1.2 -0.7 0.5 -0.8 -0.9 -0.4 -0.7 -1.3 0.8 -0.4 0.2 0.0 -0.4 -0.7 0.7
Medication for hormone replacement therapy 0.2 0.2 2.5 0.1 -0.2 -0.8 0.1 0.3 -0.3 -0.6 -1.6 -0.3 -0.5 -0.2 -0.1 -0.0 -0.3 -0.3 -0.1 0.3 -0.4 0.1 -0.5 -0.3 -0.6 -0.1 -0.1 -0.3 0.0 -0.6 -0.1 -0.1 -0.1
Vitamin and mineral supplements 0.4 0.6 2.4 0.7 0.9 -0.3 0.3 0.3 0.8 -0.6 1.1 0.8 0.8 0.9 -0.1 0.6 -1.1 -1.2 1.0 0.3 -0.5 1.5 0.9 0.9 0.3 0.8 -0.6 0.8 0.3 -0.7 0.8 0.9 -0.6
Supplements: Zinc 0.5 0.6 5.4 -0.2 -0.2 -1.2 -0.0 -0.2 -0.3 -2.1 0.9 -0.3 0.0 -0.5 0.5 -0.5 0.5 0.4 -0.5 0.0 -0.1 -0.2 -1.2 -0.6 -1.0 -0.5 0.5 -0.4 0.4 -2.3 -0.1 -0.0 0.6
Medication: Co-codamol 0.6 0.7 3.3 -1.0 -0.9 -0.3 -1.0 -1.8 -0.7 0.0 -1.0 -0.8 -1.2 -0.6 -0.9 -0.5 -0.5 0.0 -0.6 0.5 -0.9 -0.1 -1.0 -1.3 -0.6 -0.9 -0.9 -1.1 -1.0 -0.2 -1.1 -0.7 -0.7
Medication: Metformin 0.1 0.1 0.5 -0.0 -0.6 -0.3 -0.3 -0.4 -0.6 0.4 -0.1 -0.6 -0.6 -0.7 -0.1 -0.2 0.2 0.1 -0.4 0.1 0.3 -0.5 -0.2 -0.3 -0.6 -0.6 0.3 -0.1 0.0 0.2 -0.2 -0.1 0.2
Diabetes (father) 0.2 0.2 1.3 0.4 -0.0 0.2 0.3 0.1 -0.0 0.5 -0.3 -0.1 -0.5 -0.1 0.6 -0.1 0.1 -0.6 0.1 0.8 -0.0 0.0 0.5 -0.3 0.3 -0.3 0.3 0.1 0.9 0.6 0.3 1.1 0.3
Diabetes (mother) 0.2 0.3 1.0 -0.3 -0.3 0.4 -0.9 -0.1 -0.4 -0.7 -0.6 -0.6 -1.0 -0.7 -0.2 -0.5 -0.4 0.5 -0.5 0.2 -0.3 -0.8 -0.1 0.1 -0.8 -0.6 -0.4 0.0 -0.8 -0.6 -0.8 -0.2 -0.6
Severe depression (siblings) 1.3 1.5 5.3 -1.3 -1.0 -0.7 -1.6 -1.6 -0.3 0.3 -1.0 -0.7 -1.1 -0.5 -1.6 -0.1 -1.9 -1.0 -0.5 0.9 -2.1 0.4 -1.0 -1.5 -0.3 -1.1 -2.3 -1.5 -1.5 0.3 -1.8 -0.1 -1.6
Pack years adult smoking proportion 1.8 2.7 6.5 2.5 2.0 1.4 2.0 0.8 2.4 0.1 0.3 2.2 1.6 1.9 1.3 2.5 -0.6 -1.4 2.3 1.9 -0.6 1.8 1.8 1.1 1.4 2.2 0.2 1.4 1.6 0.2 1.7 2.4 0.0
Impedance of leg (right) 0.3 1.3 3.7 0.7 1.0 -0.1 1.0 0.8 1.6 0.1 -0.2 1.5 1.7 1.9 -0.4 1.7 -0.9 -1.6 1.5 1.9 -0.7 1.0 1.0 0.9 1.4 1.5 -0.6 0.5 0.6 0.7 0.9 1.0 -0.8
Leg fat-free mass (left) 0.1 0.7 3.1 0.0 -0.6 -0.9 -0.7 -1.8 0.0 -1.3 -1.0 0.0 -0.7 -0.1 -1.0 -0.2 -1.3 -0.4 0.0 -0.3 -1.1 0.3 -0.7 -0.6 -0.5 -0.2 -1.1 -0.9 -0.8 -1.5 -0.8 0.0 -1.4
Trunk fat percentage 0.5 2.0 8.1 0.2 -0.2 -0.6 -1.3 -2.9 0.4 -0.6 -1.7 0.1 -1.0 0.4 -1.2 0.4 -2.7 -1.5 0.5 1.7 -2.6 1.5 -0.7 -1.7 -0.9 -0.5 -2.5 -1.1 -1.3 -0.5 -1.2 0.6 -2.5
Hand grip strength (right) 0.9 2.4 5.5 1.7 0.8 -0.2 1.5 -0.3 2.3 -0.7 -0.2 2.3 1.6 2.2 -0.4 1.8 -1.7 -2.1 2.3 1.8 -1.2 1.8 1.8 1.8 1.8 2.2 -0.8 0.9 0.9 0.1 1.2 1.8 -1.5
Townsend deprivation index at recruitment 0.5 0.7 3.3 -0.2 -0.1 0.7 0.3 -0.1 -0.4 0.3 1.1 -0.3 -0.3 -0.3 0.8 -0.4 1.8 1.5 -0.6 -0.6 0.8 -0.3 -0.9 -1.6 -0.4 -0.3 0.9 -0.7 -0.2 0.3 0.1 -1.2 1.8
Current tobacco smoking 1.2 2.0 9.1 1.1 1.6 2.1 1.3 2.2 -0.0 1.1 2.4 0.2 0.9 -0.2 2.4 0.0 2.5 1.3 -0.2 -0.6 1.7 0.0 0.5 -0.3 0.8 0.2 2.0 0.9 1.4 1.2 1.2 0.3 3.0
Average weekly fortified wine intake 0.2 0.3 1.5 0.4 0.1 -0.5 0.1 -0.3 0.4 -1.0 -0.6 0.4 -0.2 0.2 -0.6 0.3 -0.3 -0.2 0.2 0.9 -0.3 -0.0 -0.9 -0.9 -0.2 0.4 -0.5 -1.2 -0.4 -0.9 -0.3 -0.1 -0.3
Maternal smoking around birth 0.9 1.2 6.3 -0.4 -0.1 1.1 -0.0 1.5 -1.0 2.5 1.7 -0.6 0.2 -0.8 0.4 -0.8 1.7 1.0 -0.8 -1.5 1.3 -0.5 -0.1 -0.5 0.8 -0.3 0.8 -0.1 -0.2 2.3 -0.1 -1.6 1.9
Fed-up feelings 0.1 0.2 1.2 0.5 -0.3 -0.8 -0.0 -0.6 0.3 -0.2 -0.5 0.2 0.3 0.4 -0.5 0.7 -0.8 -0.2 0.2 0.5 -0.5 0.3 -0.2 0.1 0.3 0.3 -0.4 0.1 -0.1 -0.4 -0.0 -0.1 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.9 -0.5 -1.3 -1.5 -1.1 -0.4 -0.6 -1.0 -0.6 -0.7 -1.2 -0.3 -1.4 0.1 -1.5 -0.6 -0.4 1.4 -1.3 -0.6 -1.3 -0.7 -1.5 -1.0 -1.3 -0.9 -1.1 -1.7 -1.1 -0.4 -1.4
Relative age voice broke 0.8 1.2 7.0 0.6 -0.4 0.2 0.6 0.9 -0.1 0.9 0.3 0.4 0.7 -0.1 0.3 0.1 1.6 1.4 -0.2 -2.6 2.1 -0.9 1.1 2.1 1.5 1.0 1.8 1.1 0.9 0.6 0.9 -1.0 0.7
Taking other prescription medications 0.3 0.5 3.3 0.2 -0.2 -0.5 -0.5 -1.8 0.1 0.4 -0.6 0.0 0.2 0.1 -0.7 -0.1 -0.8 -0.7 0.1 0.5 -1.3 0.7 -0.5 -1.2 -0.3 -0.3 -1.2 -0.7 -0.6 0.4 -0.6 0.1 -0.4
Age when periods started (menarche) 0.9 2.2 5.4 1.4 1.0 0.3 1.5 1.1 1.9 0.6 0.5 1.9 1.6 1.8 0.3 2.3 -1.0 -2.0 1.9 -0.1 -0.5 1.5 2.1 2.3 2.0 1.6 0.1 1.7 1.5 0.4 1.4 1.9 -1.1
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.8 -0.8 -0.5 -1.0 -1.0 -0.6 -0.5 0.1 -0.4 -0.6 -0.1 -0.3 -1.3 -0.3 -1.1 -0.7 -0.4 -0.2 -1.0 -0.5 -0.5 -0.2 -0.4 -0.9 -1.2 -0.6 -0.8 -0.2 -1.0 0.1 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 2.8 6.4 18.6 -2.9 -1.8 -0.6 -3.3 -3.3 -2.7 -1.6 -0.5 -2.9 -3.0 -2.8 -1.6 -1.9 -0.7 1.5 -2.5 0.1 -1.3 -1.6 -3.5 -3.8 -4.3 -3.0 -2.1 -3.0 -3.7 -1.6 -3.2 -3.0 -0.7
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 4.4 0.8 1.0 2.0 0.8 1.2 0.3 0.7 1.7 0.4 1.1 -0.1 1.5 -0.3 1.4 1.4 0.2 -2.1 1.5 0.2 1.3 1.5 0.8 0.8 1.5 1.6 0.5 0.8 0.8 -0.4 1.1
Qualifications: CSEs or equivalent 0.9 1.2 3.0 -1.2 -1.3 -0.8 -1.3 -0.8 -1.2 -0.4 -0.6 -1.3 -1.2 -1.1 -1.2 -1.2 0.3 1.4 -1.4 -0.7 0.5 -1.5 -1.1 -0.4 -1.1 -0.8 -0.3 -1.3 -1.5 -0.6 -1.3 -1.7 -0.3
Serious illness, injury or assault to yourself 0.2 0.2 1.0 0.0 -1.0 -0.3 -0.4 0.4 -0.4 -0.1 -0.2 -0.5 -0.4 -0.2 -0.4 0.4 0.2 0.6 -0.6 -0.8 0.5 -0.8 -0.2 0.5 -0.4 -0.4 0.2 -0.2 -0.4 -0.6 -0.5 -0.5 -0.1
High blood pressure 0.7 2.0 5.2 -0.6 -2.3 -2.0 -1.6 -1.9 -1.5 -2.1 -1.9 -1.2 -1.8 -1.5 -1.5 -1.1 -0.2 1.2 -1.4 -0.1 0.2 -1.4 -1.3 -0.1 -1.4 -1.1 -0.1 -1.3 -1.0 -2.1 -1.4 -1.4 -1.2
Hayfever, allergic rhinitis or eczema 0.2 0.4 2.5 0.1 -0.5 0.2 0.1 0.1 0.2 0.4 -0.9 0.3 0.4 0.3 -0.1 0.0 0.4 0.7 -0.0 -1.6 0.8 -0.4 0.6 1.4 1.0 0.7 0.6 0.6 0.1 0.2 0.2 -0.7 -0.5
Multivitamins +/- minerals 0.3 0.4 2.6 -0.5 -0.6 0.6 -0.3 -0.6 -0.5 -0.1 -1.6 -0.6 -0.4 -0.6 -0.1 -0.3 0.6 1.1 -0.7 -0.5 0.4 -0.7 -0.6 -0.5 0.0 -0.2 0.2 -0.7 -0.6 0.4 -0.7 -1.1 -0.0
Stomach or abdominal pain in last month 0.3 0.4 1.6 1.0 -0.1 -1.1 0.7 0.7 0.6 0.2 -0.8 0.4 0.2 0.6 0.1 0.7 -0.0 -1.0 0.5 1.0 -0.5 0.2 0.1 0.1 0.8 0.1 0.3 0.2 1.3 0.1 0.6 1.0 0.1
Supplements: Glucosamine 1.0 1.3 2.9 -1.1 -0.7 0.4 -0.9 -1.4 -1.5 0.2 -0.3 -1.6 -1.1 -1.7 0.0 -1.3 1.2 1.5 -1.6 -0.9 0.7 -1.6 -1.1 -1.6 -0.9 -1.4 0.4 -1.3 -0.8 0.4 -1.1 -1.4 0.6
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.7 1.0 0.6 -0.7 0.1 -0.3 1.3 -1.4 -0.4 1.1 0.4 1.6 -0.7 1.9 -1.9 -1.8 1.3 1.3 -1.8 1.5 0.1 0.4 0.2 1.0 -1.4 -0.0 0.1 -1.7 0.0 1.3 -1.7
Medication: Atenolol 0.5 0.6 2.9 -0.9 -0.9 -1.7 -0.9 -0.2 -0.4 -0.5 0.0 -0.3 -0.5 -0.5 -1.4 -0.9 -0.9 -0.9 -0.4 0.0 -1.1 -0.2 -0.7 -0.3 -0.5 -0.9 -1.0 -0.7 -0.4 -0.6 -0.9 0.2 -1.0
Medication: Levothyroxine sodium 1.4 2.4 7.1 2.1 0.8 0.4 2.1 0.2 2.2 -0.1 0.1 2.4 1.9 2.4 0.9 2.0 -0.2 -0.7 2.0 -0.1 0.3 1.4 1.8 2.2 1.9 2.7 0.9 1.7 1.7 -0.3 2.0 1.2 -0.6
Sitting height 0.8 5.8 15.7 2.4 1.7 0.2 1.8 -1.0 3.5 -1.2 -1.5 3.4 2.3 3.8 -0.8 4.0 -3.1 -3.2 3.5 2.3 -2.4 2.9 2.2 2.3 1.7 3.2 -1.8 1.1 0.6 -1.2 1.3 2.6 -3.1
Chronic bronchitis/emphysema (father) 0.5 0.5 2.0 0.4 1.4 0.4 0.8 0.6 0.7 0.8 0.5 0.5 1.4 0.3 0.9 0.3 0.3 -0.7 0.7 1.0 -0.4 0.7 -0.0 -0.8 0.5 0.2 0.1 0.2 0.9 1.1 0.7 0.9 1.2
High blood pressure (mother) 2.1 3.0 7.5 -1.6 -1.8 -2.7 -1.9 -1.8 -1.2 -2.1 -1.2 -1.3 -2.3 -1.3 -1.8 -1.4 -1.5 -0.3 -1.2 0.7 -1.9 -0.9 -2.5 -1.9 -2.0 -2.0 -1.5 -2.1 -1.4 -2.0 -2.2 -0.6 -1.9
Body mass index (BMI) 0.4 1.7 5.5 -0.9 -0.9 -0.4 -2.0 -2.3 -1.1 -0.5 -0.9 -1.2 -1.9 -1.6 -0.8 -1.1 -1.3 0.2 -1.0 0.2 -1.3 0.3 -1.4 -1.8 -1.8 -1.6 -1.5 -1.2 -1.8 -0.8 -1.6 -0.7 -1.2
Impedance of leg (left) 0.6 2.8 6.6 1.6 1.9 0.8 1.9 1.4 2.2 0.9 0.3 2.0 2.4 2.6 0.6 2.4 -0.6 -2.0 2.2 2.0 -0.4 1.7 1.9 1.3 2.0 2.1 -0.1 1.4 1.4 1.4 1.8 1.8 -0.2
Leg predicted mass (left) 0.1 0.7 3.0 -0.1 -0.6 -0.9 -0.7 -1.7 -0.0 -1.4 -0.9 0.0 -0.7 -0.1 -1.0 -0.2 -1.3 -0.3 -0.0 -0.3 -1.1 0.2 -0.8 -0.6 -0.6 -0.2 -1.1 -0.9 -0.8 -1.6 -0.8 0.0 -1.4
Trunk fat mass 0.5 2.2 8.4 0.2 -0.3 -0.7 -1.3 -2.9 0.5 -1.0 -1.7 0.2 -1.0 0.4 -1.4 0.6 -2.9 -1.6 0.6 1.6 -2.7 1.5 -0.7 -1.4 -1.0 -0.4 -2.6 -1.1 -1.4 -1.0 -1.2 0.6 -2.8
Waist circumference 0.4 1.3 5.8 -0.3 -0.1 0.1 -1.7 -2.4 -0.4 -0.8 -0.4 -0.6 -1.3 -0.7 -0.7 -0.4 -1.7 -0.1 -0.3 0.5 -1.6 0.8 -1.0 -1.7 -1.6 -0.9 -1.9 -1.0 -1.9 -1.1 -1.4 -0.3 -1.4
Number of incorrect matches in round 0.6 1.0 3.0 -1.2 -0.9 0.0 -1.3 -0.9 -1.2 -0.5 0.5 -1.2 -0.7 -1.0 -0.6 -1.3 0.5 1.7 -1.4 -1.3 0.7 -1.4 -0.9 -0.3 -0.9 -0.9 0.0 -0.8 -1.3 -0.8 -1.3 -1.7 -0.2
Past tobacco smoking 2.7 4.9 11.8 2.9 2.3 2.1 2.7 0.7 3.1 0.4 0.5 3.2 1.9 3.2 1.5 3.2 -0.7 -1.1 3.1 0.6 -0.0 2.0 3.2 3.0 2.1 3.4 0.6 3.0 1.6 0.6 2.5 2.1 -0.6
Alcohol usually taken with meals 0.6 1.0 3.1 1.4 0.8 0.3 1.5 0.5 1.3 -0.7 -1.4 1.4 0.9 1.8 0.6 1.3 0.3 -0.8 1.3 -0.2 0.1 0.3 0.9 1.0 0.8 1.5 0.8 0.6 1.5 -0.4 1.3 1.2 0.3
Nervous feelings 0.8 1.6 4.3 -2.1 -1.3 -2.0 -1.6 -0.5 -1.2 -0.8 -1.0 -1.3 -1.1 -1.0 -1.6 -0.5 -1.5 -0.6 -1.0 0.7 -1.3 -0.4 -1.4 -0.6 -1.6 -1.6 -1.6 -0.8 -1.5 -1.1 -1.5 -1.0 -1.1
Frequency of tenseness / restlessness in last 2 weeks 3.5 5.4 10.4 -2.6 -2.4 -2.7 -3.1 -1.8 -2.2 -1.2 -1.3 -2.5 -2.7 -2.0 -2.5 -1.3 -2.2 -0.7 -2.0 1.4 -2.6 -0.6 -3.2 -3.1 -2.8 -3.2 -2.9 -2.8 -2.6 -1.6 -3.1 -1.3 -1.8
Hearing difficulty/problems with background noise 0.8 1.2 4.0 -1.0 -1.1 -0.1 -1.5 -0.6 -1.5 1.2 -0.7 -1.8 -1.4 -1.7 -0.2 -1.8 0.1 0.6 -1.5 -1.7 -0.3 -0.4 -0.8 -1.1 -0.9 -2.0 -0.4 -0.2 -0.8 0.9 -1.1 -1.1 0.0
Hair/balding pattern: Pattern 2 0.2 0.3 1.0 0.0 0.8 0.4 0.6 -0.2 0.3 0.6 0.7 0.1 0.1 1.0 0.9 0.0 0.1 -0.4 0.2 -0.7 -0.4 0.6 -0.1 -0.8 0.4 -0.0 -0.0 0.3 0.5 0.7 0.3 0.6 0.9
Had menopause 0.9 1.1 3.5 -1.1 -0.4 -1.2 -1.5 -1.2 -0.5 -0.8 -0.5 -0.6 -0.9 -0.6 -1.6 -0.5 -1.8 -0.8 -0.2 -0.1 -1.4 0.3 -0.6 -0.4 -1.4 -0.9 -1.8 -0.3 -1.5 -0.8 -1.0 -0.5 -1.9
Had other major operations 1.2 1.5 6.1 1.0 0.4 -0.2 1.5 1.5 0.9 1.3 -0.1 1.0 1.4 1.2 0.4 0.8 0.0 -1.0 1.0 -0.4 0.5 0.1 1.8 2.5 2.3 1.2 1.1 1.7 1.9 1.0 1.3 1.4 -0.1
Forced vital capacity (FVC) 0.1 0.3 1.9 -0.1 -0.7 -0.7 0.6 0.1 0.2 -0.5 0.1 0.5 0.7 0.9 -0.6 0.2 -0.0 0.2 0.2 -1.0 0.6 -0.5 0.2 1.4 0.6 1.0 0.4 0.2 0.1 -0.8 0.2 -0.6 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.8 16.2 -2.4 -1.0 0.6 -2.6 -3.1 -2.5 -0.7 0.2 -2.5 -2.7 -2.5 -0.4 -1.8 0.6 2.3 -2.4 -0.3 -0.2 -1.6 -3.0 -4.0 -3.6 -2.5 -1.0 -2.7 -3.0 -0.5 -2.4 -3.0 0.6
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 3.7 -0.1 0.4 -0.8 0.1 -0.7 0.7 -0.7 0.2 0.7 0.3 0.5 -0.4 1.0 -1.4 -1.3 0.7 1.9 -1.2 0.8 -0.2 -0.2 0.0 0.2 -0.9 -0.3 0.2 -1.0 0.0 1.1 -0.9
Qualifications: None of the above 0.4 0.9 3.3 1.1 1.4 0.4 1.0 0.6 1.4 0.1 0.6 1.3 1.2 1.2 0.3 1.1 -0.7 -1.0 1.5 0.7 -0.4 1.8 0.9 0.6 1.1 1.5 -0.2 0.9 0.5 0.2 1.1 0.6 -0.4
Financial difficulties in last 2 years 0.4 0.5 1.4 -0.4 -1.0 -0.3 -0.7 0.1 -1.0 -0.7 0.2 -0.8 -1.2 -0.8 0.1 -0.8 0.4 1.2 -1.1 -0.9 0.6 -0.7 -0.6 -0.0 -0.6 -0.8 0.2 -0.1 -0.5 -0.7 -0.7 -0.7 0.4
Mouth/teeth dental problems 1.6 2.4 8.9 1.5 0.3 -0.0 2.0 1.3 1.9 -1.0 -0.0 2.1 2.0 2.1 0.2 2.4 0.5 -0.2 1.6 -0.9 1.1 0.8 1.9 3.0 2.1 2.9 1.1 1.4 1.5 -0.9 1.9 0.8 0.0
Heart attack 2.2 2.8 8.3 1.2 1.3 -0.3 1.2 -0.2 2.2 0.3 -0.8 1.9 0.6 2.2 -0.0 2.8 -2.2 -2.9 2.3 2.3 -2.2 2.6 1.4 0.8 1.3 1.2 -1.1 1.0 1.1 0.3 0.9 2.8 -1.8
Allergy 0.1 0.3 1.6 0.4 0.6 0.0 0.7 0.6 0.0 0.1 1.3 -0.0 0.0 0.0 0.9 0.3 0.5 0.0 0.1 0.1 0.4 -0.1 0.1 -0.1 0.0 -0.1 0.7 0.4 0.8 -0.1 0.7 0.6 0.9
Pain all over the body in last month 0.7 0.8 3.8 0.6 1.9 2.0 0.7 0.0 1.1 0.5 0.2 0.6 0.7 0.8 1.0 1.0 -0.7 -0.7 1.2 0.4 -0.8 1.3 0.9 -0.2 -0.1 0.7 -0.6 0.9 -0.2 0.9 0.6 1.1 0.0
Diabetes (self-reported) 0.2 0.3 2.2 0.5 0.7 1.0 -0.1 -0.7 0.1 -0.4 0.3 -0.0 0.1 -0.1 0.5 0.2 -0.5 -0.4 0.4 1.5 -0.5 0.7 -0.2 -1.0 -1.0 -0.0 -0.3 -0.1 -0.2 -0.6 0.1 0.4 -0.0
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.7 0.4 0.3 -0.0 0.5 0.3 0.5 0.1 -0.1 0.6 0.8 0.7 -0.1 0.3 -0.2 -0.2 0.4 0.3 0.2 -0.4 0.6 0.8 0.8 0.7 0.2 0.1 0.4 0.2 0.2 0.6 -0.4
Medication: Ramipril 0.8 1.1 4.3 -0.7 -0.2 0.5 -1.2 -0.8 -0.2 -1.5 -0.4 -0.5 -0.4 -0.3 -1.1 0.4 -1.2 -0.0 -0.2 1.7 -1.3 0.5 -0.6 -0.5 -2.0 -0.3 -1.7 -0.7 -2.1 -1.9 -1.1 -0.7 -1.1
Medication: Simvastatin 0.8 1.2 3.6 -1.0 -1.5 -1.2 -1.6 -0.8 -0.9 -0.3 -1.1 -0.9 -1.2 -0.9 -1.9 -0.1 -1.0 -0.4 -0.7 1.2 -1.1 -0.0 -1.0 -0.8 -1.0 -1.3 -1.5 -1.1 -1.5 -0.0 -1.4 -0.9 -1.2
Fluid intelligence score 0.3 0.5 2.6 -1.1 0.6 0.6 0.1 -0.7 -0.5 1.2 1.4 -0.5 0.3 -0.2 0.9 -0.2 1.0 0.3 -0.5 0.9 0.2 -0.3 -0.7 -1.6 -0.5 -0.7 0.4 -0.7 0.3 0.5 -0.0 0.1 1.5
Illnesses of siblings 2.4 3.4 11.5 0.5 1.4 2.0 1.9 2.4 0.3 2.1 3.4 0.6 1.9 0.3 2.5 0.5 2.8 1.2 0.2 -2.1 2.8 -0.1 1.7 1.3 1.6 0.9 2.6 1.9 1.9 1.8 2.0 0.5 2.9
Neuroticism score 1.5 3.1 7.3 -1.4 -2.3 -2.7 -2.1 -1.0 -1.3 -1.9 -2.6 -1.5 -1.7 -0.8 -2.7 -0.6 -1.8 -0.3 -1.3 0.6 -1.8 -1.1 -2.1 -0.8 -1.6 -1.6 -2.0 -1.7 -2.0 -2.3 -2.2 -1.3 -2.1
Weight 0.3 1.4 5.9 0.2 -0.1 -0.4 -1.0 -2.4 0.5 -1.1 -1.2 0.3 -0.7 0.3 -1.1 0.5 -2.4 -1.2 0.6 0.8 -2.2 1.4 -0.5 -0.9 -0.8 -0.1 -2.1 -0.7 -1.2 -1.3 -0.9 0.5 -2.2
Impedance of arm (right) 0.0 0.2 0.8 -0.1 -0.4 -0.8 0.2 -0.3 0.2 0.4 -0.0 0.2 0.2 0.8 -0.6 0.2 -0.1 -0.6 0.1 0.7 -0.3 -0.0 -0.4 -0.6 0.5 0.0 -0.3 -0.7 0.1 0.9 -0.1 -0.2 -0.2
Arm fat percentage (right) 0.4 1.6 6.8 -0.5 -0.8 -0.5 -1.8 -2.6 -0.8 -0.2 -0.9 -0.9 -1.7 -1.0 -0.8 -0.9 -1.6 -0.3 -0.6 0.7 -1.6 0.7 -1.3 -1.9 -1.5 -1.5 -1.7 -1.1 -1.5 -0.3 -1.5 -0.3 -1.5
Trunk fat-free mass 0.1 0.6 2.0 0.8 0.2 -0.3 0.3 -0.6 0.9 -1.2 -0.8 1.0 0.3 0.7 -0.5 0.9 -1.2 -0.9 0.9 -0.4 -0.9 0.8 0.3 0.6 0.3 0.9 -0.7 0.1 0.0 -1.4 0.1 0.7 -1.1
Hip circumference 0.6 2.4 8.4 1.3 1.2 0.6 -0.0 -2.3 1.9 -0.2 -0.9 1.6 0.4 1.8 -0.5 1.9 -2.9 -2.1 1.8 1.9 -2.6 2.4 0.8 -0.2 0.2 1.0 -2.3 0.2 -0.5 -0.3 -0.1 1.8 -2.5
Time employed in main current job 0.2 0.2 1.4 0.2 0.3 0.4 0.3 -0.2 0.7 -0.2 -0.0 0.8 -0.5 0.7 -0.2 1.2 -0.7 -0.2 0.6 0.5 -0.6 0.8 0.2 -0.1 0.1 0.6 -0.4 -0.3 -0.3 0.1 -0.0 0.1 -0.7
Alcohol intake versus 10 years previously 0.6 0.9 3.3 0.6 1.2 0.7 1.2 -0.2 0.9 0.7 0.6 0.9 0.8 0.4 1.7 1.3 -0.1 -0.8 1.1 0.8 -0.2 1.8 0.8 0.1 0.4 0.5 0.6 1.2 1.5 0.4 1.3 1.5 0.3
Father’s age at death 1.1 1.4 4.8 0.7 -1.0 -1.7 0.1 -0.8 1.2 -1.9 -1.8 0.9 0.2 0.8 -2.1 1.5 -1.8 -1.5 1.0 1.0 -1.2 -0.0 0.4 1.2 0.7 1.1 -1.4 -0.4 -0.3 -1.2 -0.2 0.7 -2.2
Worrier / anxious feelings 0.6 1.1 9.8 -0.4 -1.1 -1.8 -0.7 -0.9 -0.0 -0.2 -3.1 -0.3 -0.3 0.3 -1.8 0.1 -1.5 -1.3 0.1 0.8 -1.5 -0.2 -0.4 -0.0 -0.2 -0.5 -1.2 -0.7 -0.3 -0.4 -0.8 0.1 -2.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.8 0.2 -0.2 -0.3 0.0 0.1 0.2 0.2 0.4 0.0 -0.5 0.1 -0.1 0.6 -0.7 -0.8 0.3 0.4 -0.9 0.5 -0.2 -0.4 0.1 -0.0 -0.5 0.1 0.1 0.0 -0.1 0.3 -0.4
Falls in the last year 0.5 0.6 2.9 -0.8 -0.2 -0.1 -0.3 -0.5 -1.0 0.8 1.2 -1.0 -0.6 -0.8 0.8 -1.5 0.7 0.3 -0.9 -0.7 0.1 -0.2 -0.9 -1.7 -0.3 -1.4 0.3 -0.2 0.3 0.4 -0.2 -0.1 1.3
Hair/balding pattern: Pattern 3 0.6 0.9 2.2 -1.2 -1.0 -0.7 -1.4 -0.5 -1.3 -0.3 -0.1 -1.1 -1.5 -1.2 -0.9 -1.4 0.1 1.0 -1.3 -0.5 0.3 -0.9 -0.9 -0.2 -0.8 -1.0 -0.2 -0.8 -1.1 -0.3 -1.2 -1.4 -0.3
Number of live births 1.4 1.9 7.4 -1.2 -1.6 -0.4 -1.3 -0.6 -1.7 0.0 -1.6 -1.5 -1.1 -1.3 -1.0 -2.0 1.5 2.4 -2.0 -2.0 1.5 -2.0 -0.9 -0.1 -0.3 -0.8 0.6 -1.0 -1.3 0.1 -1.2 -2.7 0.5
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 2.3 -0.2 -0.6 -0.9 0.3 -0.7 0.4 -1.3 -0.4 0.6 0.3 0.9 -0.9 0.3 -0.6 0.1 0.3 -0.8 0.1 -0.5 0.0 1.3 0.1 1.0 -0.0 -0.1 -0.2 -1.5 -0.1 -0.4 -1.1
Pulse rate 1.9 3.1 7.6 2.1 1.9 1.6 2.0 2.0 1.9 1.8 1.4 1.9 2.3 2.0 1.6 1.4 -0.1 -1.1 2.0 0.2 0.6 1.9 2.8 2.0 1.9 1.8 0.8 2.5 1.6 1.9 2.3 1.9 0.3
Happiness 0.4 0.4 1.9 -0.0 0.0 -0.9 -0.5 -0.4 0.1 -0.9 -0.3 -0.2 -0.4 0.4 -0.7 0.2 -1.1 -0.6 -0.0 0.9 -1.4 0.3 -0.9 -0.6 -0.3 -0.5 -1.1 -0.5 -0.6 -0.9 -0.8 0.0 -0.8
Noisy workplace 2.9 3.5 8.1 2.2 1.9 1.1 2.2 1.1 2.6 0.2 1.6 2.7 1.7 1.9 1.2 2.4 -0.9 -2.0 2.7 0.8 -0.7 2.8 2.3 2.0 1.9 2.3 0.1 2.3 1.9 0.2 2.3 2.4 -0.6
Qualifications: A levels/AS levels or equivalent 0.5 1.0 4.9 -0.4 -2.0 -2.0 -0.4 0.0 -0.6 -1.5 -2.1 -0.4 -0.8 -0.3 -1.1 -0.7 0.3 0.4 -0.8 0.0 0.3 -2.2 -1.1 0.1 -0.4 -0.5 0.5 -1.3 0.2 -1.7 -0.8 -0.3 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.5 0.9 0.9 -0.1 0.2 -1.1 0.4 1.4 1.1 0.3 -0.2 0.4 0.6 0.3 -1.0 -1.5 0.6 0.7 -1.6 1.1 0.1 -1.4 0.4 -0.9 -0.8 0.1 0.7 1.2 0.2 1.4 -0.3
Mouth/teeth dental problems: Dentures 0.5 0.9 4.3 -0.2 0.9 0.3 -0.8 -1.5 -0.1 0.8 0.4 -0.3 -1.0 -0.3 0.5 -0.4 -1.4 -1.2 0.1 1.4 -1.8 1.1 -0.6 -2.1 -1.0 -1.5 -1.3 -0.2 -0.3 0.6 -0.5 0.9 -0.5
Asthma 0.8 1.6 6.0 -0.5 -1.4 -1.1 -1.3 -1.5 -0.0 -0.8 -1.8 0.0 -0.4 -0.2 -2.4 -0.6 -1.4 -1.1 -0.1 2.5 -1.8 -0.0 -0.8 -1.2 -0.6 -0.3 -2.2 -2.1 -1.5 -0.2 -1.5 -0.1 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 4.0 -0.7 -0.0 1.4 -0.5 -0.9 -1.1 1.5 0.5 -1.1 -0.8 -0.7 0.8 -0.9 1.1 1.5 -1.0 -0.2 0.7 -0.6 -0.8 -2.0 -0.4 -0.9 0.5 -1.0 -0.6 1.3 -0.6 -1.1 1.0
Medication: Cholesterol lowering 1.0 1.6 5.8 -1.4 -2.2 -2.4 -1.4 -0.5 -0.9 -1.6 -1.6 -0.8 -1.4 -1.0 -2.2 -0.1 -1.1 -0.7 -0.8 1.2 -1.2 -0.7 -1.2 -0.3 -0.9 -1.3 -1.2 -1.4 -0.8 -0.9 -1.4 -0.2 -1.7
Depression (self-reported) 1.0 1.1 3.5 -0.4 -0.6 -1.4 -1.3 -1.6 -0.4 -0.5 -1.3 -0.6 -1.2 -0.1 -1.1 -0.2 -1.6 -0.8 -0.3 0.8 -1.9 -0.2 -1.2 -1.3 -1.1 -1.2 -1.6 -0.9 -1.2 -0.7 -1.3 -0.1 -1.3
Medication: Lansoprazole 2.4 2.7 6.0 -2.2 -1.0 0.3 -2.0 -0.3 -2.1 0.2 0.2 -2.3 -2.2 -2.4 -0.0 -2.2 0.9 1.6 -2.2 -1.8 0.2 -1.3 -2.0 -2.2 -2.1 -2.5 -0.4 -1.4 -1.8 -0.6 -1.9 -1.7 1.1
Prospective memory result 0.2 0.2 1.0 0.4 0.2 -0.4 -0.2 -0.4 0.4 -0.8 -0.3 0.3 -0.3 0.2 -0.4 -0.4 -0.8 -0.4 0.3 -0.6 -0.7 0.7 0.2 0.2 0.6 0.2 -0.8 -0.0 -0.4 -0.1 -0.2 0.2 -1.0
Lung cancer (father) 0.6 0.7 2.6 -1.0 -1.3 -1.4 -0.8 0.8 -0.8 -0.6 0.0 -1.1 -0.8 -0.8 -1.0 -1.0 -0.0 0.3 -0.8 -1.6 0.3 -0.5 -1.1 0.2 -1.1 -0.8 -0.1 -0.3 -0.7 -1.4 -0.6 -0.9 -0.2
Illnesses of mother 0.5 0.6 2.3 0.2 0.8 1.4 0.9 0.6 0.4 0.5 1.3 0.7 1.5 0.6 0.7 0.7 0.9 0.4 0.5 -0.7 1.2 -0.1 0.9 0.8 0.8 1.2 0.8 0.6 0.5 0.1 1.0 -0.0 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.5 2.8 -0.3 -0.8 -0.8 0.2 -0.7 0.0 -1.0 -1.7 0.1 0.1 0.6 -0.9 -0.2 -0.2 0.3 -0.0 -1.1 0.4 -0.8 0.1 1.3 0.2 0.8 0.3 -0.2 0.0 -1.1 -0.1 -0.4 -0.9
Pulse wave Arterial Stiffness index 3.6 4.3 11.6 1.4 1.9 3.4 1.7 2.3 0.8 3.2 2.9 0.9 2.3 0.7 2.8 0.3 1.8 0.8 0.8 -2.6 2.0 1.3 2.8 2.0 2.0 1.1 2.0 3.2 1.5 2.8 2.1 0.7 2.2
Impedance of arm (left) 0.1 0.3 1.4 -0.2 -0.0 -0.3 0.0 -0.4 0.5 0.4 0.2 0.3 0.4 1.2 -0.7 0.6 -0.8 -0.9 0.4 1.1 -0.9 0.4 -0.1 -0.6 0.5 0.2 -0.8 -0.6 -0.1 0.8 -0.2 0.0 -0.8
Arm fat mass (right) 0.4 1.7 7.1 -0.3 -0.7 -0.6 -1.6 -2.7 -0.3 -0.6 -1.2 -0.4 -1.4 -0.5 -1.2 -0.3 -2.2 -0.8 -0.1 0.8 -2.1 0.9 -1.0 -1.5 -1.3 -1.0 -2.1 -1.1 -1.6 -0.8 -1.4 -0.0 -2.1
Trunk predicted mass 0.1 0.6 2.0 0.8 0.3 -0.2 0.4 -0.5 1.0 -1.1 -0.7 1.1 0.3 0.7 -0.4 1.0 -1.1 -0.8 1.0 -0.4 -0.9 0.8 0.4 0.7 0.4 1.0 -0.6 0.2 0.0 -1.4 0.2 0.8 -1.1
Standing height 0.5 4.8 13.2 2.1 1.5 -0.4 1.9 -0.3 3.3 -1.2 -1.0 3.2 2.2 3.6 -0.9 3.5 -2.8 -3.3 3.2 1.2 -2.3 2.4 1.7 1.8 2.0 2.9 -1.6 0.8 0.9 -1.0 1.3 2.3 -2.5
Length of working week for main job 0.5 0.6 3.5 -0.5 0.7 0.6 -0.2 -0.6 0.2 0.5 0.3 -0.1 -0.6 0.0 0.6 -0.2 -0.7 -1.0 0.3 1.4 -1.6 1.0 -0.6 -1.9 -0.6 -0.9 -1.0 -0.6 -0.1 0.8 -0.4 0.8 0.1
Exposure to tobacco smoke at home 1.7 2.0 4.9 1.0 1.2 -0.1 1.8 1.0 1.4 1.4 1.4 1.5 1.1 1.1 1.1 1.5 -0.2 -1.9 1.6 0.3 -0.3 1.4 1.7 0.9 2.0 1.0 0.6 1.8 2.2 1.8 1.8 2.2 0.6
Breastfed as a baby 0.6 0.8 3.0 -0.6 -1.3 -1.7 -0.3 0.5 -0.9 -1.5 -0.7 -0.9 -0.1 -1.2 -0.8 -1.0 0.6 0.5 -1.0 -0.2 0.8 -1.5 -1.0 0.0 -0.5 -0.7 0.7 -0.9 0.2 -1.7 -0.4 -0.5 0.1
Tense / ‘highly strung’ 0.7 1.2 4.1 -0.7 -0.4 -1.1 -1.2 0.0 -0.1 -1.1 -1.1 -0.4 -0.7 0.1 -1.7 0.6 -1.7 -0.9 -0.1 1.3 -2.0 -0.2 -1.1 -0.7 -1.2 -0.7 -2.0 -1.2 -1.5 -1.3 -1.3 -0.3 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 3.3 -1.0 -0.3 0.5 -1.2 -1.2 -1.1 -0.1 -0.3 -1.2 -0.7 -0.8 -0.1 -1.1 -0.0 1.1 -1.2 -0.4 -0.5 -0.2 -1.4 -1.8 -0.9 -1.1 -0.9 -1.1 -1.6 -0.2 -1.5 -1.4 0.3
Hair/balding pattern: Pattern 4 0.7 1.6 5.3 0.7 -0.1 -1.1 0.2 -0.8 1.4 -1.1 -0.7 1.3 0.8 1.5 -1.6 1.6 -2.0 -2.1 1.4 2.2 -1.6 0.7 0.8 1.0 0.6 1.2 -1.4 -0.3 0.2 -1.3 0.1 1.5 -2.3
Birth weight of first child 1.2 2.2 9.2 1.1 0.8 0.9 1.5 2.5 0.6 0.2 0.8 1.0 1.4 1.0 1.5 0.6 1.7 1.1 0.5 -2.3 2.2 -0.2 1.8 3.0 1.6 1.3 2.3 2.3 1.6 0.1 1.7 0.4 1.2
Peak expiratory flow (PEF) 1.4 3.2 7.8 1.3 0.3 -1.1 1.1 -0.7 2.4 -1.6 -0.9 2.4 0.8 2.6 -1.1 2.6 -2.8 -2.7 2.5 1.7 -2.2 2.1 1.2 1.7 0.8 2.3 -1.5 0.6 0.6 -1.6 0.9 2.0 -2.8
Pulse wave reflection index 0.9 1.1 6.6 -0.1 0.4 1.6 0.3 0.9 -0.4 1.3 1.1 -0.3 1.0 -0.3 1.3 -0.2 1.4 1.2 -0.4 -2.6 1.6 -0.1 1.0 1.2 0.9 0.1 1.4 1.5 0.6 0.8 0.6 -0.5 1.3
Ever highly irritable/argumentative for 2 days 0.5 0.7 2.3 0.0 -0.8 -0.5 -1.1 -1.5 -0.7 -0.4 -1.2 -0.7 -0.9 -0.4 -1.0 -0.5 -0.5 0.1 -0.6 0.1 -0.9 -0.3 -0.9 -1.0 -0.4 -0.8 -0.9 -1.2 -1.0 -0.3 -1.3 -0.8 -0.9
Loud music exposure frequency 1.8 2.0 6.2 -1.0 -1.0 -1.2 -1.2 -2.5 -0.2 -0.6 -2.5 -0.3 -1.4 0.1 -1.7 -0.9 -2.0 -1.3 -0.1 1.4 -2.3 -0.1 -1.4 -1.9 -0.9 -1.0 -2.0 -1.8 -1.2 -0.5 -1.6 0.1 -2.0
Qualifications: O levels/GCSEs or equivalent 1.7 2.7 6.2 -1.5 -2.1 -0.6 -1.3 -0.1 -2.3 0.1 -1.2 -2.1 -1.4 -1.9 -0.4 -2.0 2.1 2.3 -2.5 -2.1 1.5 -2.5 -1.9 -1.4 -0.9 -1.9 0.9 -1.6 -1.0 0.2 -1.5 -2.4 1.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 3.2 -0.6 -0.6 -0.6 -0.5 -1.4 -0.3 -0.6 -1.2 -0.3 -1.1 -0.4 -0.9 -0.7 -0.3 -0.1 -0.3 1.8 -0.8 -0.6 -0.8 -1.1 -0.1 -0.3 -0.7 -1.5 -0.6 0.1 -1.0 -0.3 -0.6
Blood clot in the leg (DVT) 0.3 0.3 1.0 -0.6 -0.4 -1.0 -0.7 0.3 -0.6 -0.7 0.2 -0.5 -0.6 -0.5 -0.6 -0.6 0.0 0.3 -0.6 -0.5 -0.2 -0.6 -0.9 -0.3 -0.9 -0.7 -0.1 -0.6 -0.4 -0.8 -0.6 -0.6 -0.2
Medication: Paracetamol 0.5 0.8 2.0 -1.0 -1.1 -0.8 -0.6 0.6 -1.4 0.8 0.5 -1.3 -0.8 -1.3 -0.1 -1.2 0.9 0.7 -1.2 -0.5 0.7 -0.6 -1.1 -1.0 -0.7 -1.4 0.4 -0.4 -0.3 0.4 -0.4 -1.2 0.9
Headache pain in last month 1.6 2.7 6.8 -1.5 -1.3 0.2 -1.2 -0.8 -2.2 0.9 1.4 -2.0 -1.9 -2.2 0.9 -2.4 1.9 2.6 -2.2 -1.6 1.5 -1.9 -2.0 -2.1 -1.5 -2.0 1.1 -0.8 -0.8 0.7 -0.9 -2.4 1.4
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 1.4 0.9 1.2 1.1 1.1 0.8 0.7 1.1 0.1 0.5 0.9 1.0 0.8 0.3 0.4 -0.2 0.7 -0.1 0.4 0.5 0.8 0.4 1.0 0.8 0.4 0.7 0.6 0.9 0.8 0.2 1.0
Glaucoma (self-reported) 2.2 2.6 6.5 1.9 1.3 1.0 2.1 1.3 2.4 0.3 0.3 2.5 2.1 2.6 0.6 2.3 -0.8 -1.5 2.3 0.8 -0.6 1.8 1.8 1.8 1.9 2.6 0.1 1.4 1.4 -0.1 1.7 1.7 -0.5
Gout (self-reported) 1.3 1.8 6.5 -1.2 -2.6 -2.3 -1.5 0.5 -1.6 -1.3 -1.6 -1.5 -1.8 -1.4 -1.6 -1.5 0.1 0.5 -1.6 -0.8 0.6 -2.2 -1.0 0.6 -1.0 -1.6 0.3 -0.9 -0.3 -1.5 -1.2 -0.9 -0.8
Hypothyroidism/myxoedema (self-reported) 1.9 3.6 8.9 2.7 0.9 0.0 2.2 -0.2 2.9 -0.0 0.2 3.0 2.2 2.9 0.2 2.9 -1.3 -2.3 2.9 1.6 -1.0 2.2 2.0 1.6 1.8 2.8 -0.3 1.3 1.4 0.2 2.1 2.3 -1.2
Medication: Amlodipine 0.5 0.7 3.9 -0.4 -1.1 -1.2 -0.8 -0.3 -0.2 -1.5 -1.4 -0.0 -0.6 -0.1 -1.4 -0.4 -0.7 0.1 -0.3 0.1 -0.3 -0.6 -0.5 0.7 -0.4 -0.1 -0.4 -0.7 -0.6 -2.0 -0.8 -0.3 -1.4
Medication: Ventolin 100micrograms inhaler 0.4 0.6 2.0 -0.3 -1.3 -0.6 -0.6 -0.5 0.1 0.6 -1.2 -0.0 -0.4 0.1 -1.4 0.2 -0.6 -0.6 -0.1 1.0 -0.8 -0.2 -0.2 -0.8 0.3 -0.3 -1.2 -1.3 -0.9 1.4 -0.8 -0.2 -0.6
Birth weight 0.2 0.4 1.6 -0.7 -0.3 -0.0 -1.0 -0.9 -0.5 -0.7 0.7 -0.3 -0.8 -0.5 -0.9 -0.3 -0.4 0.5 -0.6 -0.4 -0.3 -0.4 -0.3 -0.1 -0.5 -0.3 -0.8 -0.7 -1.3 -0.5 -1.0 -0.9 -0.6
Chronic bronchitis/emphysema (mother) 5.0 5.8 12.2 -2.5 -2.8 -1.5 -3.0 -1.7 -3.3 -0.3 -0.9 -3.1 -2.8 -3.3 -1.6 -3.5 0.7 1.9 -3.3 -1.4 -0.1 -2.5 -3.2 -3.1 -2.0 -3.2 -0.8 -3.1 -2.3 -0.4 -3.0 -3.0 0.4
High blood pressure (siblings) 4.9 7.0 13.2 -2.2 -3.2 -3.2 -3.2 -3.0 -2.4 -2.8 -3.2 -2.6 -3.3 -2.5 -2.9 -2.2 -1.6 0.8 -2.4 1.1 -1.6 -2.0 -3.6 -2.6 -3.3 -2.8 -2.0 -3.3 -2.9 -2.7 -3.3 -2.4 -2.2
Forced vital capacity (FVC), Best measure 0.1 0.4 2.8 -0.4 -0.9 -0.6 0.2 -0.2 -0.1 -0.4 -1.7 -0.1 0.4 0.4 -0.9 -0.5 0.0 0.4 -0.2 -1.2 0.6 -0.8 0.1 1.2 0.5 0.6 0.4 -0.1 -0.0 -0.5 -0.1 -0.7 -0.6
Body fat percentage 0.4 1.6 7.5 0.1 -0.2 -0.5 -1.4 -2.7 0.1 -0.6 -1.4 -0.1 -1.0 0.1 -1.1 0.2 -2.4 -1.2 0.3 1.4 -2.2 1.3 -0.7 -1.4 -1.0 -0.6 -2.2 -0.9 -1.3 -0.6 -1.1 0.5 -2.4
Leg fat percentage (right) 0.4 1.6 5.9 -0.3 -0.4 -0.6 -1.7 -2.4 -0.3 -0.9 -1.3 -0.4 -1.3 -0.4 -1.3 -0.3 -2.1 -0.6 -0.2 1.3 -1.8 0.7 -0.9 -1.3 -1.3 -0.8 -2.1 -1.0 -1.6 -1.0 -1.4 -0.2 -2.2
Arm fat-free mass (right) 0.2 0.9 2.4 1.1 0.8 0.1 0.4 -0.6 1.3 -1.1 -0.7 1.2 0.6 1.0 -0.2 1.2 -1.6 -1.1 1.2 0.0 -1.2 1.1 0.7 0.8 0.4 1.0 -0.9 0.5 0.0 -1.3 0.2 1.2 -1.4
Exposure to tobacco smoke outside home 0.8 1.1 3.5 1.3 0.8 -0.2 0.7 -0.1 1.2 1.6 0.9 1.2 0.3 0.9 0.1 1.5 -0.9 -1.9 1.3 0.7 -1.2 1.8 0.9 -0.2 1.3 0.6 -0.7 0.4 0.9 1.5 0.6 1.7 -0.3
Comparative body size at age 10 0.6 1.5 4.1 -1.4 -0.0 1.0 -1.2 -1.1 -1.7 1.1 0.1 -1.7 -0.7 -1.7 0.8 -2.0 1.0 1.7 -1.6 -1.0 0.7 -0.1 -1.2 -1.8 -1.4 -1.6 0.2 -0.4 -1.1 0.9 -0.9 -1.7 1.3
Number of full brothers 0.8 1.0 2.3 -0.5 -0.5 -1.2 -1.1 -1.3 -0.5 -1.5 -1.0 -0.9 -1.1 -0.7 -1.0 -0.8 -1.0 -0.5 -0.4 0.6 -1.4 0.3 -1.4 -1.5 -1.3 -0.8 -1.4 -1.1 -1.0 -1.4 -1.0 -0.4 -0.6
Worry too long after embarrassment 1.7 2.9 6.1 -2.3 -2.0 -1.6 -2.1 -0.7 -2.0 -1.1 -0.7 -1.9 -2.1 -1.6 -1.6 -1.6 -0.5 1.2 -2.0 -1.0 -0.4 -1.7 -2.5 -1.3 -1.9 -1.8 -1.0 -1.8 -2.2 -1.5 -2.2 -2.5 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.7 -0.6 0.2 1.0 -0.4 -0.9 -0.6 0.3 -0.8 -0.7 -0.2 -0.2 0.6 -0.3 0.6 1.2 -0.7 -0.4 0.1 -0.5 -0.7 -1.3 -0.5 -0.5 -0.1 -0.4 -0.9 -0.0 -0.5 -1.0 0.8
Wheeze or whistling in the chest in last year 0.2 0.4 1.6 0.4 -0.8 -0.9 -0.6 0.3 0.0 0.5 -1.2 -0.2 -0.7 0.0 -1.0 -0.1 -0.8 -1.0 -0.1 -0.1 -1.0 0.1 0.0 -0.2 0.7 -0.6 -0.9 -0.3 -0.1 1.3 -0.7 0.5 -0.7
Number of children fathered 0.3 0.3 0.8 0.7 0.6 0.9 0.6 -0.3 0.3 0.5 -0.4 0.5 0.4 0.1 0.8 0.4 0.6 0.6 0.3 0.1 0.8 0.3 0.8 0.6 0.4 0.6 0.9 0.6 0.6 0.6 0.7 0.3 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 4.1 -1.4 -2.0 -0.5 -1.8 -1.3 -1.5 -0.8 -1.9 -1.5 -1.0 -1.2 -1.4 -1.1 0.5 1.2 -1.6 -0.2 0.0 -1.8 -1.6 -1.1 -1.0 -1.0 -0.5 -1.8 -1.4 -0.8 -1.6 -2.0 -0.4
Age at first live birth 0.6 1.0 6.5 0.5 -0.3 -0.5 1.0 1.7 0.4 -1.2 -0.3 0.5 0.8 0.7 0.2 -0.2 0.8 0.4 0.3 -0.9 1.5 -0.8 1.1 2.5 1.4 1.1 1.5 1.1 1.2 -0.9 0.9 0.5 0.4
Pulse wave peak to peak time 3.2 3.8 10.6 -1.1 -1.7 -3.3 -1.4 -2.2 -0.5 -3.1 -2.8 -0.6 -2.0 -0.4 -2.7 -0.1 -1.8 -1.0 -0.6 2.6 -2.1 -1.2 -2.6 -1.9 -1.8 -0.9 -1.9 -3.0 -1.3 -2.7 -1.9 -0.5 -2.2
Health satisfaction 0.3 0.4 2.0 0.0 0.8 0.3 0.4 -0.3 0.3 1.3 1.3 0.4 0.7 0.3 0.7 0.9 -0.1 -0.5 0.5 0.9 -0.3 1.4 0.1 -0.7 0.4 0.0 -0.0 0.2 0.5 1.0 0.4 0.7 0.2
Shortness of breath walking on level ground 1.0 1.2 4.8 0.0 0.2 0.3 -0.4 -1.9 0.9 0.1 -0.3 0.6 -0.2 0.8 -0.8 0.9 -2.2 -1.4 0.8 1.9 -2.0 1.7 0.1 -0.8 -0.3 0.1 -2.1 -0.7 -1.1 0.1 -0.8 0.9 -1.9
Qualifications: College or University degree 0.2 0.7 2.5 -1.2 -0.8 -1.6 -0.5 -0.5 -0.3 -1.0 -1.1 -0.4 -0.5 -0.3 -1.0 -0.3 -0.9 -1.1 -0.1 1.2 -1.2 -0.0 -0.9 -0.6 -1.0 -0.8 -0.7 -0.9 0.0 -1.0 -0.6 0.7 -0.7
Eye problems/disorders: None of the above 2.7 3.1 6.9 -1.8 -1.4 -0.8 -2.2 -1.6 -2.3 0.4 0.6 -2.3 -2.0 -2.5 -0.8 -2.1 0.6 1.7 -2.3 -1.3 0.4 -1.7 -2.2 -2.6 -2.2 -2.5 -0.4 -2.0 -1.9 0.5 -1.9 -2.3 0.3
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.2 1.0 0.2 1.0 1.1 0.5 0.5 0.6 0.4 0.7 0.5 0.4 0.9 0.1 0.6 0.5 0.5 -0.3 1.0 0.1 0.6 0.5 1.1 1.1 1.1 0.6 0.9 0.5 1.1 0.0 0.2
Emphysema/chronic bronchitis 1.1 1.2 6.0 -0.8 -0.6 0.5 -1.4 -1.3 -1.1 0.8 1.1 -1.2 -1.1 -1.3 -0.3 -1.1 0.0 0.7 -1.2 0.1 -0.6 -0.0 -1.4 -2.5 -0.9 -1.4 -1.1 -1.4 -1.6 0.8 -1.3 -1.7 0.4
Medication for pain relief, constipation, heartburn 0.5 0.8 3.1 0.4 0.4 0.6 0.6 0.8 0.0 -0.3 0.2 0.1 0.4 -0.5 0.9 -0.3 1.5 1.4 -0.4 -1.7 1.8 -1.2 0.8 1.5 0.8 0.5 1.6 1.0 0.8 0.1 0.5 -0.0 1.1
Neck or shoulder pain in last month 0.6 0.8 3.2 -0.7 -0.8 0.4 -1.1 -1.3 -0.8 0.9 -0.6 -1.0 -1.8 -1.0 -0.1 -0.6 -0.3 0.3 -0.9 -0.3 -0.9 -0.3 -0.8 -1.6 -0.6 -1.4 -0.8 -1.0 -0.7 1.0 -1.3 -0.1 -0.2
Medication: Blood pressure 0.5 0.9 2.5 -0.5 -1.1 -1.0 -1.4 -1.6 -0.8 -1.0 -0.5 -0.6 -1.4 -1.2 -1.0 -0.8 -0.7 0.6 -0.8 0.4 -0.5 -0.7 -0.9 -0.5 -1.4 -0.9 -0.6 -1.0 -1.1 -1.1 -1.1 -0.6 -1.5
Angina (self-reported) 0.5 0.7 1.6 -0.4 -1.1 -1.0 -0.5 0.1 -1.2 -0.7 -1.2 -1.1 -1.0 -1.3 0.0 -1.1 1.1 0.9 -1.1 -0.6 0.6 -0.8 -0.9 -0.4 -0.8 -1.2 0.8 -0.3 0.2 -0.3 -0.3 -0.6 0.7
Migraine (self-reported) 0.9 1.2 2.5 -1.3 -0.8 -0.4 -1.2 -0.8 -1.6 -0.7 0.1 -1.6 -1.2 -1.6 -0.2 -1.5 0.5 1.4 -1.6 -0.6 0.3 -1.5 -1.2 -0.9 -1.3 -1.3 -0.0 -0.8 -1.1 -0.5 -1.2 -1.4 0.3
Medication: Ibuprofen 0.8 0.9 4.1 -0.7 -0.3 0.9 -0.8 -1.4 -1.2 0.7 0.1 -1.2 -0.6 -0.7 0.3 -0.7 0.7 1.5 -1.1 0.2 0.6 -0.7 -1.3 -2.0 -0.9 -0.8 0.2 -1.3 -1.0 0.3 -0.9 -1.5 0.4
Medication: Allopurinol 1.4 1.9 5.1 -1.5 -2.1 -1.5 -1.8 -0.3 -1.8 -0.6 -1.2 -1.8 -1.7 -1.5 -1.6 -2.0 0.0 0.8 -1.8 -1.0 0.3 -2.3 -1.2 -0.1 -1.2 -1.9 -0.1 -1.1 -1.0 -0.8 -1.7 -1.3 -0.9
Medication: Omeprazole 0.4 0.5 2.0 -0.5 0.5 -0.2 -0.5 -1.0 0.3 0.7 -0.6 -0.0 0.2 0.3 -0.4 -0.1 -0.9 -0.9 0.2 0.7 -1.3 0.7 -0.5 -1.4 0.1 -0.7 -1.0 -0.9 -0.2 1.2 -0.6 0.5 -0.6
Medication: Seretide 50 evohaler 0.2 0.2 2.0 0.3 -1.2 -1.4 -0.4 0.1 -0.3 -0.4 -1.1 -0.2 -0.4 -0.0 -0.8 -0.0 -0.4 -0.5 -0.1 0.5 -0.2 0.1 0.0 0.6 -0.0 -0.3 -0.3 0.1 0.1 0.0 -0.0 0.1 -0.3
Mean time to correctly identify matches 0.2 0.4 1.5 -0.2 0.1 -0.3 -0.5 -0.6 0.2 0.4 -0.7 -0.0 0.5 0.2 -0.9 0.2 -0.9 -0.9 0.2 0.6 -1.2 0.4 -0.3 -0.8 -0.7 -0.3 -1.2 -0.7 -0.7 0.2 -0.4 0.1 -0.7
Heart disease (mother) 0.4 0.5 3.6 0.1 -0.5 -1.1 0.0 0.5 0.1 0.2 -1.4 -0.1 -0.4 0.3 -0.6 0.1 -0.9 -1.9 0.5 1.5 -1.4 0.6 -0.1 -0.2 -0.2 -0.4 -0.7 -0.1 0.6 -0.2 0.1 1.1 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 2.0 0.3 -0.5 -0.6 -0.3 -0.8 0.1 -0.8 0.3 0.1 -0.8 -0.5 -0.3 -0.1 -0.2 0.0 -0.1 1.4 -0.1 -0.1 -0.4 -0.5 -0.6 -0.2 -0.3 -0.7 -0.1 -0.5 -0.3 0.4 -0.3
Whole body fat mass 0.5 1.9 7.6 0.1 -0.5 -0.8 -1.4 -2.8 0.2 -1.0 -1.5 -0.0 -1.1 0.0 -1.4 0.3 -2.7 -1.3 0.3 1.3 -2.4 1.3 -0.7 -1.2 -1.1 -0.6 -2.4 -0.9 -1.4 -1.1 -1.2 0.4 -2.7
Leg fat mass (right) 0.4 1.6 5.7 -0.2 -0.6 -0.8 -1.6 -2.4 -0.2 -1.2 -1.3 -0.3 -1.2 -0.4 -1.3 -0.2 -2.2 -0.8 -0.1 1.0 -1.9 0.8 -0.9 -1.1 -1.3 -0.7 -2.0 -0.9 -1.5 -1.5 -1.3 0.0 -2.3
Arm predicted mass (right) 0.1 0.7 2.3 0.8 0.6 0.0 0.1 -0.8 1.0 -1.1 -0.7 1.0 0.5 0.8 -0.4 0.9 -1.5 -1.0 1.0 0.1 -1.3 1.0 0.4 0.4 0.1 0.7 -1.0 0.2 -0.2 -1.5 -0.0 1.1 -1.4
Pulse rate, automated reading 0.5 1.5 4.4 1.1 0.9 0.8 1.3 1.7 0.7 1.5 2.1 0.9 2.0 1.0 1.2 1.0 1.2 0.2 0.7 -0.6 1.4 0.5 1.5 1.1 1.4 0.9 1.4 1.4 1.3 1.4 1.5 0.8 1.2
Alcohol intake frequency. 0.3 0.8 3.2 0.2 0.5 -0.3 0.2 -1.7 0.6 0.2 0.6 0.4 -0.6 0.1 0.1 0.8 -1.1 -1.3 0.7 1.6 -1.7 1.3 -0.7 -1.8 -1.0 -0.5 -1.1 -0.5 -0.0 0.0 -0.2 1.1 -0.5
Comparative height size at age 10 0.2 0.9 3.7 0.7 1.1 1.0 1.2 1.9 0.4 1.1 1.2 0.4 1.1 0.6 1.2 0.2 1.0 -0.1 0.5 -0.7 1.0 0.3 0.6 0.1 0.7 0.5 0.9 0.6 0.9 1.2 1.1 0.6 1.9
Number of full sisters 0.8 0.9 3.2 1.0 1.3 1.3 1.3 1.1 0.6 0.9 1.8 0.6 0.8 0.4 1.4 0.2 0.9 0.2 0.6 -0.4 0.9 0.4 1.0 0.5 0.8 0.8 1.1 1.1 1.1 1.2 1.2 0.7 1.1
Suffer from ‘nerves’ 2.6 4.0 8.4 -2.5 -2.4 -1.9 -2.5 -0.9 -2.8 -0.7 -1.4 -2.9 -2.2 -2.6 -1.5 -2.4 0.3 1.6 -2.7 -0.8 0.0 -2.5 -2.6 -1.6 -2.4 -2.9 -0.4 -1.9 -1.9 -1.2 -2.3 -2.5 -0.1
Overall health rating 0.6 1.4 4.5 -1.3 -0.8 -0.8 -1.7 -1.1 -1.4 0.0 0.0 -1.6 -1.8 -1.4 -0.5 -0.6 -0.5 -0.1 -1.2 0.6 -1.0 -0.2 -1.6 -2.1 -1.9 -2.0 -1.1 -1.1 -1.2 -0.1 -1.3 -0.7 -0.3
Chest pain or discomfort 1.0 1.5 3.6 -1.0 -1.2 -0.3 -1.5 -1.6 -1.0 1.4 -1.3 -1.2 -1.9 -0.8 -1.2 -0.7 -1.0 -0.8 -0.8 1.4 -1.6 -0.7 -0.8 -1.8 -0.7 -1.6 -1.5 -1.6 -1.0 1.6 -1.6 0.1 -1.1
Had major operations 0.8 1.0 6.4 0.5 -0.2 -0.8 -0.3 -1.3 0.7 -1.7 -1.1 0.6 -0.4 0.6 -0.9 0.2 -1.5 -1.1 0.6 2.5 -1.8 0.6 -0.5 -0.6 -0.6 0.3 -1.4 -0.6 -0.4 -1.1 -0.3 0.5 -1.0
Age at last live birth 0.7 1.0 4.8 -0.1 -1.2 -1.9 0.3 1.0 -0.2 -1.6 -1.4 -0.0 0.2 0.4 -0.9 -0.7 0.7 0.8 -0.5 -1.1 1.4 -1.9 0.2 2.2 1.0 0.7 1.2 0.2 0.6 -1.4 0.1 -0.5 -0.1
Family relationship satisfaction 1.2 1.5 6.4 1.0 0.3 -1.4 0.2 -0.7 1.2 -1.1 -0.7 1.2 0.1 1.1 -1.3 1.1 -2.1 -2.5 1.3 2.0 -2.3 1.0 -0.0 -0.2 0.6 0.4 -1.6 -0.4 0.3 -0.7 -0.2 1.5 -1.7
Leg pain on walking 0.1 0.1 0.5 0.0 0.3 0.6 0.2 0.3 -0.0 0.3 0.3 -0.0 -0.1 -0.3 0.3 0.2 0.6 0.4 -0.2 0.4 0.1 -0.1 -0.5 -0.7 0.0 -0.2 0.3 -0.4 0.2 -0.1 -0.2 -0.0 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.7 0.3 -0.5 -0.7 -0.6 -1.2 -0.1 0.0 -1.2 -0.3 -1.3 -0.3 -0.9 -0.3 -0.6 -0.6 -0.2 0.5 -1.0 -0.3 -0.4 -0.9 0.4 -0.5 -0.9 -1.1 -0.4 0.6 -0.9 0.1 -0.8
Commuting to job workplace: Car/motor vehicle 1.7 2.0 7.3 0.3 -0.4 -1.0 -0.9 -2.5 0.9 -0.2 -2.4 0.7 -0.3 0.1 -1.7 0.8 -2.5 -2.0 0.8 2.2 -2.7 0.6 0.0 -0.6 -0.0 -0.1 -2.2 -1.2 -0.6 -0.2 -1.0 1.2 -2.7
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.9 -0.9 0.4 0.2 -0.3 -0.2 -0.1 -0.0 -0.1 -0.2 0.6 -0.4 -0.1 -0.3 0.0 0.0 -0.1 0.0 -0.2 0.4 -0.3 -0.4 -0.5 -0.1 -0.3 -0.1 -0.4 -0.0 -0.1 -0.4 -0.1
Medication: Aspirin 1.0 1.3 4.8 0.1 -0.4 -1.6 -0.4 -0.9 0.6 -1.2 -1.0 0.7 0.5 0.5 -1.6 1.1 -2.2 -2.0 0.9 1.6 -2.1 1.3 -0.3 -0.2 -0.5 0.3 -1.8 -0.7 -0.6 -1.3 -0.3 0.8 -2.0
Supplements: Vitamin C 0.4 0.5 3.0 0.2 0.6 0.9 0.3 -0.6 0.1 0.4 1.7 0.2 -0.1 -0.3 0.8 0.3 0.7 0.4 0.0 1.2 -0.2 -0.5 -0.6 -1.7 -0.6 -0.1 0.1 -0.9 -0.1 0.3 -0.1 0.2 1.1
Knee pain experienced in last month 3.3 5.1 10.0 -2.8 -2.6 -1.7 -3.0 -1.9 -2.5 -1.9 -2.1 -2.8 -3.2 -2.5 -1.8 -2.0 -0.1 1.8 -2.7 -1.0 -0.4 -2.4 -2.9 -1.7 -2.6 -2.6 -0.9 -2.3 -2.4 -2.3 -2.8 -2.6 -1.1
Hypertension (Self-reported) 0.5 1.5 4.6 -0.2 -1.9 -1.9 -1.3 -2.2 -0.9 -1.9 -2.0 -0.7 -1.7 -1.0 -1.5 -0.5 -0.6 0.5 -0.9 0.6 -0.4 -0.8 -1.0 -0.2 -1.1 -0.8 -0.4 -1.2 -0.7 -1.9 -1.2 -0.6 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 3.3 -0.3 0.6 0.7 -0.1 1.1 -0.0 1.8 0.7 -0.1 0.0 -0.2 0.5 -0.4 -0.0 -0.3 -0.1 -0.5 -0.4 0.7 0.1 -0.5 0.7 -0.6 -0.2 0.3 0.1 1.8 -0.1 0.2 0.6
Illnesses of father: Heart disease 1.5 2.0 5.8 1.8 1.7 0.3 1.0 -0.4 1.9 0.1 -0.4 1.7 0.9 1.7 0.4 2.2 -1.9 -2.4 2.0 1.7 -2.2 1.9 1.1 0.0 0.7 1.1 -1.2 0.9 0.8 0.6 0.8 2.4 -0.9
Illnesses of siblings: Diabetes 0.5 0.6 2.1 -0.9 -0.6 -0.3 -1.2 -1.5 -0.6 -0.1 -1.0 -0.7 -1.4 -0.7 -0.5 -0.9 -1.0 -0.5 -0.5 0.5 -1.1 0.3 -0.3 -0.9 -0.4 -1.0 -1.2 -0.5 -0.6 0.1 -1.0 0.4 -0.8
Smoking status: Previous 5.1 7.6 14.7 -3.4 -3.5 -3.0 -3.3 -1.1 -3.7 -1.3 -1.6 -3.8 -2.8 -3.6 -2.3 -3.8 0.8 1.8 -3.7 -1.2 0.3 -3.1 -3.8 -2.9 -2.5 -3.7 -0.5 -3.5 -2.1 -1.5 -3.1 -3.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.2 4.5 1.7 1.9 1.1 2.1 1.2 1.7 0.7 0.5 1.8 1.9 1.9 1.7 1.7 0.0 -1.0 1.8 0.0 0.2 1.6 1.7 1.4 1.5 1.7 0.9 1.9 1.8 0.4 2.0 1.7 0.5
Whole body fat-free mass 0.1 0.5 2.5 0.6 -0.1 -0.6 0.0 -1.0 0.7 -1.3 -0.9 0.7 0.0 0.4 -0.6 0.5 -1.2 -0.7 0.6 -0.4 -1.0 0.6 0.0 0.3 0.1 0.5 -0.7 -0.2 -0.1 -1.6 -0.1 0.6 -1.2
Leg fat-free mass (right) 0.0 0.2 1.6 0.4 -0.1 -0.3 -0.1 -1.3 0.3 -0.8 -0.5 0.3 -0.2 0.2 -0.1 0.1 -0.8 -0.4 0.3 -0.5 -0.7 0.5 -0.2 -0.4 -0.1 0.0 -0.5 -0.3 -0.2 -1.0 -0.2 0.4 -0.7
Arm fat percentage (left) 0.4 1.7 7.0 -0.6 -0.7 -0.4 -1.9 -2.6 -0.8 -0.2 -0.8 -1.0 -1.8 -0.9 -0.8 -0.8 -1.9 -0.4 -0.6 0.7 -1.8 0.8 -1.2 -2.0 -1.6 -1.5 -1.9 -1.1 -1.7 -0.5 -1.6 -0.2 -1.7
Average weekly red wine intake 0.5 0.7 3.0 0.0 0.3 0.5 0.5 0.8 -0.3 1.3 0.7 -0.0 0.4 0.2 1.0 -1.1 1.4 0.7 -0.3 -1.7 1.4 -0.5 0.3 0.1 0.5 -0.2 1.3 0.5 0.8 1.5 0.7 -0.2 1.4
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.8 1.5 0.9 0.5 1.3 0.9 1.5 0.4 0.3 1.4 0.8 1.4 0.4 1.7 -0.4 -0.9 1.4 0.6 -0.0 0.9 1.2 1.2 1.2 1.7 0.3 0.9 1.0 0.0 1.2 1.1 -0.3
Mood swings 0.3 0.5 1.4 1.1 -0.4 -1.2 0.6 0.7 0.6 -0.9 -1.0 0.4 0.8 1.2 -0.4 0.9 -0.5 -0.7 0.6 0.4 -0.3 0.2 -0.1 0.6 0.6 0.7 0.1 0.2 0.7 -1.2 0.4 0.6 -0.5
Loneliness, isolation 0.3 0.5 1.7 1.2 0.7 0.5 0.6 -1.3 1.0 -0.2 -0.3 1.0 0.4 0.9 0.3 1.2 -0.7 -0.6 0.9 0.4 -1.0 0.4 0.3 -0.5 0.4 0.7 -0.4 0.1 0.3 0.2 0.3 0.9 -0.5
Long-standing illness, disability or infirmity 0.2 0.4 2.3 0.2 0.1 0.2 0.0 -0.7 0.2 0.2 0.5 0.2 -0.4 0.7 0.4 0.6 -0.5 -0.8 0.4 1.5 -1.2 1.1 -0.2 -1.1 -0.6 -0.2 -0.6 -0.1 0.1 -0.2 -0.0 0.9 0.4
Ever had bowel cancer screening 1.6 1.9 7.7 -1.1 -1.0 1.0 -1.2 0.7 -1.8 0.4 1.1 -1.7 -0.7 -1.9 0.2 -1.6 1.6 2.5 -1.9 -2.8 1.3 -1.6 -1.0 0.1 -1.0 -1.4 0.9 0.0 -1.0 -0.5 -1.2 -2.2 0.9
Diabetes diagnosed by doctor 0.2 0.2 1.0 0.1 0.0 0.4 -0.3 0.2 -0.7 -0.1 0.7 -0.7 -0.4 -1.0 0.7 -0.2 0.4 0.4 -0.4 0.3 0.4 0.2 -0.6 -0.8 -1.0 -0.6 0.4 0.1 0.0 -0.4 0.1 -0.2 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 3.5 -0.8 -0.5 0.7 -0.6 -0.4 -0.9 0.2 -0.5 -0.9 -0.5 -0.7 0.2 -1.0 1.4 1.9 -1.2 -1.3 0.9 -1.6 -0.5 -0.5 -0.4 -0.7 0.5 -0.6 -0.7 0.4 -0.8 -1.2 1.0
Friendships satisfaction 0.4 0.6 1.7 0.8 0.6 0.2 0.1 -0.8 0.7 0.2 1.3 0.8 0.6 0.9 -0.2 0.4 -1.2 -1.2 0.9 0.8 -1.1 1.3 0.5 0.0 0.3 0.4 -1.0 0.5 -0.1 0.4 0.2 0.5 -1.1
Qualifications: nursing, teaching 0.2 0.4 1.8 0.3 0.9 0.5 0.3 -0.4 0.8 -0.2 -0.6 0.8 0.2 0.8 0.4 0.6 -0.6 -0.8 0.8 1.4 -0.8 0.7 0.4 -0.2 0.0 0.6 -0.2 -0.1 0.5 -0.1 0.3 1.1 -0.7
Commuting to job workplace: Walk 1.1 1.2 4.5 -0.5 -1.1 -0.4 -0.6 -0.4 -1.5 -1.6 0.1 -1.2 -0.6 -0.8 -0.2 -0.9 1.1 2.1 -1.4 -1.6 1.6 -1.6 -0.9 0.5 -0.9 -0.4 1.0 -0.2 -0.7 -1.5 -0.5 -2.1 0.3
Eye problems/disorders: Cataract 0.1 0.2 0.8 -0.1 -0.1 -0.5 -0.1 0.5 -0.2 -0.4 -0.8 -0.2 0.5 -0.2 0.2 0.1 -0.3 -0.2 -0.1 -0.9 -0.2 0.2 -0.0 0.9 0.2 0.0 0.1 0.7 0.2 -0.9 0.1 0.0 -0.2
Mouth/teeth dental problems: Mouth ulcers 3.5 5.5 12.5 -3.1 -1.9 -0.5 -3.0 -1.9 -3.3 0.2 -0.3 -3.3 -2.7 -3.0 -1.1 -3.1 0.2 2.0 -3.1 -1.7 -0.4 -2.1 -3.1 -2.7 -3.2 -3.5 -1.0 -1.8 -2.7 -0.1 -3.0 -3.1 0.1
Medication for cholesterol 0.7 1.0 5.2 -0.2 1.1 2.3 0.4 0.5 0.2 1.9 1.7 0.0 0.5 -0.1 1.6 -0.2 1.2 1.0 0.0 -0.9 1.1 0.4 0.8 -0.1 0.6 0.2 0.8 0.9 0.2 2.2 0.7 -0.2 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 5.6 0.9 0.2 -1.8 0.3 -0.2 1.4 -1.3 -1.6 1.3 0.6 1.5 -1.1 1.2 -2.3 -2.4 1.5 1.6 -1.9 1.2 0.5 0.9 0.7 0.9 -1.3 0.4 0.5 -1.1 0.4 1.4 -2.0
Back pain experienced in last month 0.9 1.3 2.7 -0.7 -1.5 -0.6 -1.1 -1.0 -1.6 -0.2 0.3 -1.6 -1.2 -1.5 -0.5 -1.3 1.1 1.3 -1.6 -1.0 0.5 -1.5 -1.5 -1.2 -1.0 -1.2 0.2 -1.3 -0.8 -0.6 -1.1 -1.6 0.7
Mineral and other dietary supplements 0.8 1.1 2.7 0.5 0.1 -0.8 0.4 1.1 1.3 -0.2 0.6 1.2 0.6 1.5 -1.0 1.3 -1.5 -1.6 1.3 1.2 -0.9 1.2 1.2 1.7 0.7 1.1 -1.1 0.8 -0.1 -0.5 0.4 1.2 -0.9
Breast cancer (self-reported) 2.2 2.6 9.5 -0.3 0.6 0.7 0.6 1.6 -1.3 2.4 3.1 -1.1 0.7 -1.6 2.4 -1.1 2.4 1.3 -1.0 -2.8 2.3 -0.5 0.2 -0.1 -0.3 -1.2 2.5 1.6 1.4 1.4 1.1 -0.3 2.9
Asthma (self-reported) 0.5 1.1 3.9 -0.4 -1.1 -0.9 -1.0 -1.1 0.1 -0.5 -1.4 0.1 -0.1 -0.2 -2.0 -0.4 -1.2 -0.9 -0.1 2.0 -1.5 0.1 -0.6 -1.0 -0.3 -0.2 -1.8 -1.8 -1.2 0.1 -1.3 0.0 -1.2
Osteoporosis (self-reported) 0.8 1.0 3.2 -1.0 -1.8 -1.0 -1.1 -1.0 -0.7 -1.1 -1.5 -0.9 -0.9 -1.0 -1.2 -1.2 -0.2 0.7 -0.9 -0.6 -0.0 -1.4 -1.2 -0.4 -1.1 -0.7 -0.3 -1.1 -1.0 -1.5 -1.1 -1.1 -0.8
Osteoarthritis (self-reported) 1.6 2.0 4.6 -1.7 -1.0 -0.1 -1.3 -0.4 -2.1 1.6 0.5 -2.1 -1.4 -2.1 0.1 -1.8 1.5 1.8 -2.1 -1.3 1.1 -1.6 -1.4 -1.5 -1.0 -2.1 0.7 -0.8 -0.6 1.1 -1.1 -1.8 1.2
Medication: Aspirin 1.4 1.8 6.7 0.8 0.0 -1.2 0.3 -0.5 1.4 -0.4 -0.7 1.4 1.2 1.3 -1.1 1.8 -2.3 -2.6 1.7 1.9 -2.2 2.2 0.6 0.4 0.5 0.9 -1.6 0.1 0.2 -0.5 0.3 1.5 -1.9
Medication: Gliclazide 0.8 0.9 5.3 -0.8 0.3 0.1 -0.8 -1.4 -0.4 -0.2 0.0 -0.5 -0.2 -0.7 -0.7 -0.1 -1.2 -0.8 0.0 2.3 -1.4 0.2 -1.0 -2.1 -1.4 -0.6 -1.4 -1.3 -1.1 -0.2 -0.8 -0.3 -0.6
Illnesses of father: None of the above (group 1) 3.0 3.7 10.3 -2.5 -2.2 -1.2 -2.0 -0.6 -2.3 -0.9 -0.2 -2.2 -1.7 -2.1 -1.5 -3.0 1.3 2.6 -2.6 -2.9 1.2 -2.8 -2.0 -0.6 -1.6 -1.8 0.2 -1.6 -2.0 -1.1 -1.9 -3.2 0.2
Smoking status: Current 1.3 2.0 9.1 1.1 1.7 2.0 1.4 2.1 -0.0 1.0 2.1 0.2 0.9 -0.2 2.5 0.1 2.5 1.2 -0.1 -0.7 1.8 -0.0 0.8 -0.0 0.9 0.3 2.1 1.1 1.6 1.1 1.3 0.5 3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 3.6 -0.7 -1.3 -0.7 -0.7 -1.9 -0.6 -1.2 -1.6 -0.4 -0.8 -0.1 -1.2 -1.1 -0.5 0.8 -0.6 -1.4 0.4 -0.6 -0.3 0.7 -0.3 0.2 -0.1 -0.4 -0.9 -1.3 -0.7 -1.2 -1.4
Whole body water mass 0.1 0.5 2.3 0.7 0.0 -0.5 0.0 -1.0 0.6 -1.3 -0.8 0.7 0.1 0.4 -0.5 0.5 -1.1 -0.7 0.6 -0.4 -0.9 0.6 -0.0 0.2 0.1 0.5 -0.7 -0.2 -0.2 -1.5 -0.1 0.6 -1.1
Leg predicted mass (right) 0.0 0.2 1.5 0.5 -0.1 -0.3 -0.1 -1.2 0.3 -0.8 -0.5 0.3 -0.2 0.2 -0.1 0.1 -0.8 -0.3 0.3 -0.5 -0.7 0.5 -0.2 -0.3 -0.1 0.1 -0.5 -0.3 -0.1 -1.1 -0.2 0.4 -0.7
Arm fat mass (left) 0.5 2.0 7.7 -0.4 -0.7 -0.7 -1.8 -2.8 -0.3 -0.9 -1.3 -0.5 -1.5 -0.5 -1.4 -0.3 -2.4 -0.8 -0.2 0.9 -2.3 0.8 -1.1 -1.5 -1.5 -1.0 -2.4 -1.2 -1.8 -1.1 -1.6 -0.1 -2.4
Number of self-reported non-cancer illnesses 1.0 1.7 5.9 -1.1 -1.2 -0.8 -1.6 -2.0 -0.8 -0.4 -0.9 -1.0 -1.4 -0.8 -1.4 -0.6 -1.2 -0.6 -0.7 1.1 -1.8 -0.3 -1.6 -2.4 -1.6 -1.6 -1.8 -2.0 -1.6 -0.3 -1.8 -0.2 -1.1
Average weekly champagne plus white wine intake 0.9 1.2 8.1 0.1 -1.9 -1.6 -0.5 0.2 -0.3 -2.8 -1.1 -0.2 -0.6 -0.1 -1.6 -0.6 0.0 0.6 -0.5 -0.5 1.1 -1.2 0.1 2.0 0.0 0.8 0.4 -0.3 -0.3 -2.6 -0.2 -0.6 -1.0
Miserableness 0.2 0.4 1.5 -0.2 -0.6 -0.7 -0.8 -0.6 -0.7 0.2 -0.8 -0.9 -0.1 -0.3 -0.3 -0.6 -0.3 0.4 -0.9 -0.4 -0.4 -0.5 -1.2 -0.9 -0.5 -0.9 -0.5 -0.5 -0.5 -0.7 -0.8 -0.6 -0.1
Guilty feelings 1.5 2.2 6.4 -1.0 -2.2 -1.3 -1.3 -0.5 -2.0 -0.5 -2.5 -2.0 -1.2 -1.7 -1.1 -1.6 1.1 2.0 -2.2 -1.5 0.9 -2.0 -1.6 -0.6 -0.3 -1.4 0.3 -1.5 -1.0 -0.5 -1.5 -2.3 0.1
Wears glasses or contact lenses 0.5 0.5 1.4 1.0 0.9 0.9 0.8 0.0 1.0 -0.8 0.3 0.9 0.5 0.3 0.8 1.1 0.0 -0.4 0.9 0.8 -0.1 0.5 0.9 0.7 0.2 0.9 0.4 0.8 0.9 -0.6 0.9 1.2 0.0
Ever taken oral contraceptive pill 0.5 0.5 3.3 0.8 0.2 0.8 0.2 1.3 -0.1 0.5 0.3 0.2 -0.0 0.0 0.2 0.0 0.6 0.7 -0.1 -0.0 1.0 -1.2 1.4 1.8 0.7 0.5 0.9 0.9 0.4 0.7 0.3 0.3 0.2
Hearing aid user 0.3 0.4 2.2 0.4 0.4 0.6 0.5 0.5 0.5 0.3 -0.2 0.2 0.1 0.3 0.5 -0.2 -0.3 -0.3 0.5 -0.8 0.5 0.4 1.3 1.5 0.5 0.5 0.4 1.2 0.5 0.5 0.8 0.8 -0.7
Mother’s age at death 0.1 0.2 1.0 0.5 0.3 -0.2 -0.1 0.6 0.3 0.2 1.0 0.0 -0.2 0.1 0.2 0.5 -0.8 -0.4 0.2 0.5 -0.5 0.3 -0.1 0.1 -0.4 -0.2 -0.3 0.4 -0.1 -0.2 -0.1 0.4 -0.5
Financial situation satisfaction 0.4 0.5 2.0 0.3 0.1 -1.1 -0.2 -0.8 0.5 -0.8 -0.6 0.5 -0.7 0.5 -0.9 0.7 -1.4 -0.9 0.4 0.9 -1.3 0.6 -0.4 -0.1 -0.1 0.2 -1.1 -0.3 -0.5 -0.8 -0.4 -0.0 -1.4
Tinnitus: Yes, now most or all of the time 1.1 1.3 4.6 -1.7 -0.1 -0.2 -0.9 0.5 -1.7 0.1 1.8 -1.5 -0.7 -2.1 0.4 -1.4 0.8 1.2 -1.5 -1.2 0.9 -0.3 -1.4 -1.3 -1.2 -1.3 0.3 -0.5 -0.8 0.2 -0.7 -1.3 1.4
Commuting to job workplace: Public transport 0.6 0.7 2.9 -0.4 0.5 1.1 0.2 0.0 -0.5 1.7 1.5 -0.6 -0.2 0.0 1.3 -0.1 1.0 0.6 -0.5 0.2 0.4 0.3 -0.4 -1.7 0.0 -0.7 0.5 -0.3 0.2 1.5 0.0 -0.1 1.6
Eye problems/disorders: Glaucoma 5.8 6.9 16.3 3.1 2.1 1.7 3.4 2.1 3.7 0.8 0.8 3.9 3.2 3.9 0.9 3.4 -0.7 -2.4 3.6 1.6 -0.5 2.4 3.3 3.0 3.5 4.0 0.5 2.2 2.5 0.9 2.8 2.9 -0.5
Medication: Blood pressure 0.7 1.4 4.7 -0.6 -1.8 -2.2 -1.3 -0.9 -0.9 -1.9 -1.8 -0.8 -1.2 -0.7 -1.9 -0.7 -0.7 0.0 -0.9 -0.3 -0.5 -0.9 -1.2 0.0 -1.2 -0.9 -0.7 -1.0 -1.0 -2.1 -1.3 -1.0 -1.3
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.9 -0.3 -0.6 0.1 -0.0 -0.9 -0.3 1.4 0.2 -0.2 -0.4 -0.2 -0.2 0.2 0.3 -0.0 -0.3 1.1 0.0 -0.4 -0.3 -1.0 0.0 -0.3 0.1 -1.0 0.2 0.9 -0.2 0.1 0.1
Supplements: Fish oil (including cod liver oil) 1.5 2.0 5.5 -1.6 -1.0 -0.1 -1.6 -2.3 -1.6 -0.8 -1.9 -1.7 -1.7 -1.6 -0.7 -1.5 0.0 1.2 -1.6 -0.3 -0.4 -1.2 -1.9 -2.0 -1.5 -1.6 -0.7 -1.8 -1.6 -0.4 -1.8 -1.8 -0.5
High cholesterol (Self-reported) 0.3 0.5 1.9 0.2 -0.9 -1.1 -0.1 -0.2 0.4 -0.5 -0.7 0.6 0.2 0.5 -1.4 0.9 -0.9 -1.0 0.4 1.4 -0.8 0.1 -0.0 0.0 0.2 0.1 -0.8 -0.7 -0.1 -0.3 -0.3 0.6 -1.2
Medication: Bendroflumethiazide 0.9 1.4 6.5 0.6 -1.0 -1.9 -0.5 -0.6 0.7 -2.2 -2.1 0.7 -0.3 1.0 -2.0 0.8 -1.6 -0.9 0.6 1.1 -0.9 -0.2 0.1 1.5 -0.1 0.9 -1.0 -0.3 -0.5 -2.0 -0.4 0.1 -2.5
Medication: Paracetamol 0.1 0.2 0.9 -0.5 -0.5 -0.2 -0.4 0.2 -0.6 0.3 0.3 -0.5 -0.4 -0.4 -0.3 -0.6 0.1 0.2 -0.5 0.1 -0.1 -0.2 -0.9 -0.9 -0.6 -0.6 -0.3 -0.5 -0.5 0.0 -0.4 -0.8 0.2
Medication: Lisinopril 0.4 0.5 3.7 0.4 0.0 -1.9 0.4 0.5 0.4 -1.2 -0.3 0.5 0.4 0.5 0.1 0.0 -0.6 -1.2 0.6 0.7 -0.6 0.3 0.1 0.6 0.2 -0.1 0.2 0.6 1.2 -1.2 0.7 1.2 -0.2
Medication: Atorvastatin 0.6 0.7 2.9 0.2 0.7 -0.3 1.4 0.6 0.3 -1.1 0.9 0.5 0.9 0.4 1.2 0.2 1.1 0.5 0.2 -0.2 1.3 -0.0 0.3 0.8 0.5 0.6 1.7 0.8 1.6 -0.9 1.2 0.8 1.1
Illnesses of father: High blood pressure 1.8 2.2 8.4 1.7 0.1 -1.4 0.9 0.2 1.4 -0.6 -2.1 1.2 0.3 1.9 -0.2 2.1 -2.2 -2.7 1.9 2.9 -1.5 1.8 1.2 1.0 0.8 0.9 -0.6 0.9 1.2 -0.0 1.0 2.1 -1.8
Alcohol drinker status: Never 1.3 1.5 6.0 -1.3 -0.2 -0.5 -1.5 -2.3 -0.7 -0.5 0.3 -0.9 -1.4 -0.8 -0.7 -1.0 -1.1 -0.1 -0.8 0.5 -1.5 0.0 -1.9 -2.4 -1.6 -1.5 -1.6 -1.7 -1.5 -0.5 -1.6 -0.6 -0.9
Ever smoked 2.4 4.1 9.7 -2.5 -1.2 -0.3 -2.1 -0.3 -2.9 0.5 1.0 -3.0 -1.3 -2.9 -0.4 -3.0 1.8 2.1 -3.1 -1.0 0.8 -2.0 -2.8 -3.1 -1.8 -3.0 0.2 -2.4 -1.4 0.3 -2.1 -2.4 1.9
Basal metabolic rate 0.1 0.6 2.2 0.6 0.0 -0.4 -0.1 -1.3 0.7 -1.2 -1.0 0.7 -0.1 0.5 -0.6 0.6 -1.5 -0.9 0.7 -0.0 -1.3 0.9 -0.1 -0.0 -0.1 0.4 -1.1 -0.3 -0.4 -1.4 -0.2 0.6 -1.4
Leg fat percentage (left) 0.3 1.0 4.1 0.3 0.3 0.1 -1.1 -2.0 0.3 -0.5 -1.1 0.0 -0.7 0.1 -0.7 0.2 -2.0 -0.9 0.4 1.4 -1.7 1.2 -0.3 -1.0 -0.9 -0.3 -1.8 -0.4 -1.1 -0.6 -0.7 0.4 -1.9
Arm fat-free mass (left) 0.2 0.8 2.5 0.8 0.1 -0.6 -0.0 -1.1 0.9 -1.4 -1.3 0.9 0.3 0.7 -0.7 0.8 -1.6 -1.0 0.9 0.1 -1.3 0.9 0.2 0.5 0.1 0.7 -1.1 0.0 -0.3 -1.5 -0.1 0.8 -1.6
Number of operations (self-reported) 0.4 0.6 3.1 -0.2 0.2 -0.6 -0.5 -0.4 0.3 0.1 -1.1 0.1 -0.5 0.2 -0.7 0.5 -1.6 -1.3 0.4 1.8 -1.4 0.2 0.3 0.2 -0.2 -0.3 -1.2 0.1 -0.3 0.4 -0.4 1.0 -1.0
Average weekly beer plus cider intake 0.8 1.1 5.3 -1.8 0.3 -0.0 -1.2 -0.0 -0.7 0.7 0.7 -1.2 -0.9 -1.2 -0.5 -0.5 -0.8 -0.6 -0.7 0.8 -1.4 -0.1 -1.4 -2.3 -1.6 -1.6 -1.5 -1.3 -1.4 0.1 -1.3 -0.4 -0.1
Irritability 1.8 3.0 8.9 -1.4 -1.9 -1.8 -1.9 -1.8 -0.9 -2.6 -2.7 -1.2 -1.2 -0.8 -2.3 -0.2 -2.0 -0.3 -0.9 1.0 -1.7 -0.6 -1.9 -1.1 -2.1 -1.2 -2.0 -2.0 -2.0 -3.0 -2.0 -0.8 -2.5
Risk taking 0.4 0.6 2.6 0.8 1.2 1.0 0.9 1.0 0.4 -0.2 1.1 0.5 0.3 0.0 1.5 0.8 0.8 -0.2 0.4 0.9 0.0 0.1 0.0 -0.8 0.2 0.2 0.6 -0.0 1.1 -0.2 0.7 1.2 1.6
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.8 -1.0 -1.2 -0.4 -1.0 0.3 -1.2 -0.7 0.6 -0.9 -0.7 -1.1 -0.6 -0.8 0.5 1.0 -1.2 -0.8 0.3 -0.9 -1.1 -0.6 -1.1 -0.9 -0.1 -0.8 -0.8 -0.8 -0.8 -1.3 0.5
Fractured/broken bones in last 5 years 0.4 0.5 2.0 -0.3 -0.6 -0.5 -0.7 -0.4 0.1 -0.6 -1.4 -0.1 -0.7 0.4 -1.3 -0.2 -1.1 -0.5 -0.1 0.4 -1.0 -0.1 -0.1 0.3 0.3 -0.1 -1.2 -0.8 -0.8 -0.3 -1.0 0.2 -1.4
Age started oral contraceptive pill 1.6 2.0 5.2 -1.4 -1.0 -1.0 -1.9 -1.8 -0.5 -0.9 -1.0 -0.7 -1.3 -0.5 -2.2 0.6 -1.8 -0.4 -0.6 0.8 -1.7 -1.0 -1.2 -0.9 -2.2 -1.1 -2.1 -1.7 -2.2 -1.5 -2.0 -0.6 -2.3
Diastolic blood pressure, automated reading 0.3 1.0 2.6 1.6 0.5 -0.0 1.1 0.6 0.8 0.3 0.4 1.0 1.5 1.6 0.8 0.8 0.7 0.1 0.8 -0.4 1.2 0.1 1.5 1.5 1.2 1.3 1.2 1.1 1.3 0.3 1.5 0.8 0.6
Ever depressed for a whole week 0.1 0.2 1.3 0.3 0.4 -0.5 0.1 0.1 0.1 -0.6 1.1 0.1 0.6 0.3 -0.1 -0.2 -0.2 -0.5 0.1 0.9 -0.2 -0.3 -0.2 -0.3 0.2 -0.1 -0.3 -0.3 0.2 -0.5 0.1 0.4 0.3
Unable to work because of sickness or disability 1.2 1.5 3.9 1.2 1.4 -0.2 1.5 1.4 1.7 -0.4 0.6 1.6 0.5 2.0 0.5 1.8 -0.6 -1.6 1.6 1.3 -1.0 1.1 0.9 1.1 1.3 1.3 -0.0 1.2 1.5 -0.7 1.2 1.9 0.2
Commuting to job workplace: Cycle 1.2 1.4 7.2 -0.2 0.4 1.2 1.1 2.7 -0.6 1.2 1.1 -0.3 0.5 -0.6 1.4 -0.3 2.2 1.2 -0.4 -1.0 2.0 -0.9 0.6 0.9 0.1 -0.0 2.1 1.1 1.0 1.2 1.0 -0.4 2.2
Myopia 4.1 6.0 11.8 -2.6 -2.2 -1.6 -3.2 -1.3 -2.8 -2.3 -1.0 -3.2 -2.5 -3.2 -1.8 -2.5 -0.3 2.1 -3.0 -1.5 -0.2 -2.3 -3.3 -2.2 -3.4 -2.9 -1.2 -2.5 -3.3 -2.7 -3.2 -3.2 -0.6
Vascular/heart problems diagnosed by doctor 0.9 2.3 6.9 0.8 2.4 2.6 1.7 2.0 1.4 2.6 2.3 1.1 1.9 1.4 1.9 0.8 0.8 -0.4 1.2 -0.3 0.4 1.1 1.4 0.1 1.5 1.2 0.5 1.3 0.9 2.5 1.4 1.0 1.9
Cholesterol lowering medication 0.0 0.1 0.4 0.0 -0.1 -0.4 0.0 0.2 -0.3 0.0 0.6 -0.0 0.5 0.0 -0.2 -0.1 0.4 0.2 -0.2 -0.0 0.4 0.2 -0.1 0.0 0.4 -0.0 0.2 -0.0 0.1 -0.1 -0.0 -0.2 0.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 1.0 -0.8 -0.1 -0.3 -0.8 -0.3 -0.2 0.2 -0.8 -0.4 -0.1 0.0 -0.7 -0.2 -0.4 -0.1 -0.2 0.1 -0.7 0.3 -0.8 -1.0 -0.4 -0.6 -0.8 -0.9 -0.8 0.4 -0.7 -0.5 -0.4
Pain experienced in last month 0.8 1.4 3.0 1.0 1.6 -0.3 1.5 0.7 1.7 -0.4 0.0 1.7 1.7 1.6 0.1 0.8 -0.8 -1.6 1.7 0.7 -0.5 1.3 1.5 1.3 1.5 1.5 -0.0 1.1 1.2 0.3 1.3 1.7 -0.3
Supplements: Calcium 1.0 1.1 8.5 -0.2 -0.3 -0.2 0.5 0.6 -0.8 0.0 -0.0 -0.7 0.5 -0.7 1.2 -0.9 1.8 1.5 -0.8 -2.9 1.9 -1.3 0.2 0.6 0.3 -0.3 2.2 0.7 1.0 0.0 0.5 -0.3 1.1
Basal cell carcinoma (self-reported) 0.4 0.5 3.2 0.4 0.3 0.9 -0.2 0.3 -0.6 1.5 -0.2 -0.6 0.4 -0.8 0.9 -0.6 0.6 0.7 -0.4 -1.8 0.7 0.5 0.3 -0.1 0.3 -0.3 0.3 0.7 -0.2 1.6 0.2 -0.8 0.8
Heart attack/myocardial infarction (self-reported) 1.8 2.4 7.0 1.3 1.2 -0.2 1.3 0.0 2.0 0.2 -0.5 1.9 0.7 2.0 0.2 2.6 -1.7 -2.5 2.1 1.9 -1.8 2.4 1.4 0.9 1.3 1.3 -0.7 1.1 1.3 0.1 1.0 2.6 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.6 -0.1 -0.1 -0.8 -0.2 0.4 -0.2 -0.7 0.3 -0.0 -0.2 -0.1 -0.3 -0.3 0.2 0.3 -0.2 -0.6 0.1 -0.4 -0.5 0.2 -0.3 -0.2 0.3 -0.2 0.1 -0.6 -0.1 -0.3 -0.2
Heart disease (siblings) 0.8 1.0 3.3 0.7 -0.9 -1.5 -0.4 0.3 0.6 -1.6 -1.2 0.4 -0.4 0.6 -1.3 0.2 -1.8 -1.7 0.7 0.7 -1.5 0.8 0.1 1.0 0.2 0.4 -1.1 0.1 0.0 -1.8 -0.2 0.8 -1.6
Alcohol drinker status: Previous 0.3 0.3 2.1 -0.2 0.1 -0.9 0.5 1.3 0.4 0.3 -0.1 0.3 0.2 -0.1 0.2 0.2 -0.3 -1.4 0.6 0.8 -0.7 1.0 -0.1 -0.3 -0.0 -0.2 -0.2 0.4 0.7 0.1 0.5 1.0 0.6
Pack years of smoking 1.9 2.8 6.6 2.5 1.9 1.1 1.7 0.2 2.5 -0.1 0.1 2.4 1.4 2.1 0.8 2.6 -1.3 -2.0 2.5 2.4 -1.3 2.1 1.7 1.0 1.2 2.1 -0.5 1.2 1.2 0.0 1.5 2.5 -0.7
Impedance of whole body 0.2 1.1 4.0 0.8 0.9 0.1 1.0 0.4 1.4 0.7 -0.1 1.2 1.4 2.0 -0.1 1.6 -0.8 -1.6 1.4 1.7 -0.7 1.1 0.9 0.4 1.3 1.2 -0.5 0.4 0.7 1.2 0.8 0.9 -0.6
Leg fat mass (left) 0.3 1.3 5.1 0.1 -0.2 -0.5 -1.3 -2.2 0.1 -0.9 -1.2 -0.1 -0.9 -0.2 -1.0 0.1 -2.2 -1.0 0.2 1.1 -1.9 1.2 -0.5 -0.9 -1.1 -0.5 -2.0 -0.6 -1.3 -1.1 -1.0 0.4 -2.2
Arm predicted mass (left) 0.1 0.6 2.1 0.8 0.4 -0.2 -0.0 -1.1 0.9 -1.3 -0.9 0.9 0.3 0.6 -0.5 0.8 -1.4 -0.7 0.8 -0.1 -1.2 0.9 0.1 0.3 -0.0 0.7 -1.0 -0.1 -0.4 -1.5 -0.1 0.7 -1.3