Hub : Genes

ZNF382

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1330	0.0450	4.1e-12	0.052	0.110	0.095	0.11	0.093	6.0e-07	2.9e-13	1.4e-11	3.1e-13	2.1e-11
2	GTEx	Brain Cerebellar Hemisphere	0.2280	0.1120	2.1e-03	0.142	NA	0.046	NA	0.117	1.8e-04	NA	2.5e-02	NA	6.5e-04
3	GTEx	Brain Cerebellum	0.2350	0.0700	1.7e-06	0.212	NA	0.230	NA	0.239	6.6e-07	NA	2.0e-07	NA	1.1e-07
4	TCGA	Brain Lower Grade Glioma	0.0682	0.0413	5.6e-04	0.025	0.009	0.002	NA	0.012	7.3e-04	2.8e-02	1.9e-01	NA	1.3e-02
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.0350	0.0260	8.1e-03	0.020	0.027	0.015	NA	0.015	1.5e-02	6.1e-03	3.0e-02	NA	3.1e-02
6	TCGA	Prostate Adenocarcinoma	0.0714	0.0341	5.1e-07	0.073	0.068	0.070	NA	0.074	4.1e-08	1.2e-07	7.6e-08	NA	3.7e-08
7	TCGA	Thyroid Carcinoma	0.0440	0.0250	3.7e-04	0.036	0.032	0.033	NA	0.035	1.7e-04	3.7e-04	3.4e-04	NA	2.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.5	2.4	3.5	1.6	-1.4	-1.9	-1.3	-1.8	-1.5	-1.1
Bipolar Disorder or Schizophrenia	1.5	3.8	7.0	2.1	-1.8	-1.7	-1.6	-2.7	-1.9	-1.5
Depressed Affect (Nagel 2018)	0.4	0.7	1.8	0.4	-0.5	-0.8	-1.0	1.0	-0.7	-1.4
Depression (Nagel 2018)	1.3	1.9	4.8	0.5	-2.2	-1.3	-1.4	0.9	-1.0	-1.6
Intelligence (Savage-Jansen 2018)	2.5	7.7	10.3	1.2	-3.2	-3.2	-3.2	-1.9	-3.0	-3.0
Neuroticism (Nagel 2018)	0.2	0.6	1.3	-0.4	1.1	1.0	0.6	0.8	0.7	0.3
Schizophrenia (2018)	0.8	1.6	3.8	1.4	-1.2	-0.7	-1.0	-1.9	-1.2	-1.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.1	0.1	0.2	-0.2	-0.5	-0.4	-0.6
Worry (Nagel 2018)	0.9	1.9	3.5	-1.1	1.9	1.8	1.4	0.2	1.3	1.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	0.9	-0.2	-1.2	-0.3	-0.9	-0.3	-0.2
Alzheimer’s Disease (in father)	0.0	0.1	0.1	-0.2	-0.0	-0.1	-0.2	0.3	-0.2	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.7	0.9	-0.5	-1.3	-0.3	-1.2	-0.7	-0.6
Crohns Disease (2017)	0.5	1.1	1.8	-0.5	1.2	1.2	1.3	0.2	1.1	1.3
Irritable Bowel Disease (IBD)	0.6	1.5	2.9	-0.7	1.3	1.7	1.5	0.8	1.3	0.8
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.1	0.1	0.7	0.3	0.6	0.2	-0.6
Major Depression (MDD)	0.8	0.9	4.5	-1.3	-0.0	-0.4	0.0	2.1	0.3	-0.1
Reaction Time	0.3	0.6	2.8	-0.3	0.0	-0.1	-0.8	1.7	-0.3	-0.9
Verbal and Numeric Reasoning (VNR)	1.2	2.8	3.5	0.8	-1.9	-1.8	-1.9	-1.5	-1.9	-1.8
Breast Cancer	0.1	0.3	0.9	-0.7	0.3	0.4	0.4	0.9	0.6	0.3
Ovarian Cancer	2.8	3.7	4.9	-1.6	1.9	1.5	1.8	2.1	2.2	2.2
Prostate Cancer	0.2	0.2	0.8	0.9	-0.4	0.4	0.3	-0.6	0.0	0.1
Age at First Birth	0.2	0.2	0.6	-0.3	-0.6	-0.5	-0.8	0.0	-0.5	-0.4
Bipolar Disorder (2011)	5.2	5.1	6.9	2.4	-2.3	-2.6	-2.0	-2.5	-2.1	-1.7
Body Mass Index (BMI) (2010)	0.7	1.0	1.3	1.0	-1.0	-0.9	-1.0	-0.6	-1.1	-1.1
Coronary Artery Disease (CAD)	0.2	0.3	0.9	0.4	-0.2	-0.3	-0.5	0.5	-0.3	-1.0
Crohns Disease (2012)	0.2	0.2	0.9	1.0	0.0	-0.5	-0.4	-0.3	-0.5	-0.2
Mean Putamen Volume	2.1	2.4	4.2	1.0	-1.3	-1.9	-2.1	0.2	-1.6	-1.9
Fasting Glucose	1.9	2.3	3.7	1.9	-1.1	-1.8	-1.3	-1.0	-1.4	-1.8
HbA1C	0.3	0.3	0.7	0.5	0.8	0.5	0.5	0.2	0.5	0.6
HDL Cholesterol	1.1	1.8	3.1	-1.2	1.3	1.1	1.7	0.3	1.4	1.8
LDL Cholesterol	0.3	0.4	0.8	-0.4	0.8	0.6	0.6	0.9	0.6	0.5
Lupus	0.3	0.5	1.6	-0.5	1.3	0.9	0.7	0.1	0.5	0.3
Neuroticism (2016)	0.5	0.7	2.4	-0.8	0.5	0.7	0.6	1.6	0.8	0.5
Primary Biliary Cirrhosis	1.7	2.5	4.8	-0.0	2.0	2.2	1.8	0.3	1.6	1.7
Rheumatoid Arthritis	2.0	2.7	3.6	1.7	-1.7	-1.5	-1.9	-0.8	-1.9	-1.7
Schizophrenia (2014)	0.6	1.2	4.6	1.1	-0.9	-0.3	-0.6	-2.1	-1.0	-0.6
Triglycerides	0.3	0.5	1.1	0.0	-1.0	-0.7	-0.8	0.8	-0.5	-0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	0.2	-0.6	-1.1	-0.8	-0.7	-0.8	-0.8
Ulcerative Colitis	0.6	0.9	3.0	-0.3	0.9	1.7	1.0	0.7	0.7	0.1
Blood Eosinophil Count	0.0	0.1	0.4	0.6	0.3	-0.4	-0.3	-0.1	-0.2	0.1
Blood Platelet Count	2.4	27.7	33.8	5.4	-4.8	-5.0	-5.1	-5.4	-5.8	-5.3
Blood Red Count	0.2	1.9	9.5	-1.8	0.3	-0.1	-0.4	3.1	0.2	-0.4
Blood White Count	1.4	10.5	16.8	1.9	-4.1	-3.4	-3.6	-2.2	-3.6	-3.1
Heel T-Score	0.0	0.2	1.5	-1.2	-0.3	-0.1	0.2	0.1	0.1	-0.3
BMI	1.1	6.2	12.2	1.9	-2.6	-3.5	-2.5	-0.9	-2.5	-2.8
Height	0.2	3.0	9.0	0.1	3.0	2.3	1.6	0.1	1.7	1.3
Waist Hip Ratio (WHR)	0.2	0.7	1.1	-0.6	0.7	1.1	0.9	0.9	0.8	1.0
Systolic Blood Pressure	0.2	1.2	3.5	-0.1	1.9	1.4	1.1	0.7	1.0	0.8
Smoking Status	1.8	4.3	7.1	-0.8	2.7	2.3	2.3	0.4	2.2	2.6
Allergy or Eczema	1.4	3.7	5.7	-0.9	2.0	1.8	2.2	1.3	2.4	2.4
Cardiovascular Disease	0.8	2.6	6.0	-1.5	2.4	1.8	1.1	1.7	1.3	1.1
Hypothyroidism (self reported)	2.7	6.3	8.6	-2.9	2.3	2.4	2.5	2.4	2.6	2.4
Respiratory disease	0.1	0.1	0.2	-0.4	0.4	0.4	0.2	0.4	0.2	0.5
Type 2 Diabetes (T2D) (2018)	1.4	2.7	4.2	-1.7	1.6	1.1	1.6	2.0	1.7	1.6
Lung FEV1/FVC ratio	4.3	21.7	27.7	3.4	-4.3	-5.0	-5.1	-4.0	-5.3	-5.2
Lung FVC	0.6	3.2	7.0	-1.1	0.8	2.6	1.7	1.8	1.8	2.0
Neuroticism	0.2	0.4	1.1	-0.4	1.0	0.9	0.5	0.2	0.5	-0.0
Chronotype (morning person)	2.7	6.2	9.6	-0.5	3.1	3.0	3.0	-0.6	2.4	3.0
Hair Pigment	0.1	4.2	7.0	-1.2	2.0	1.9	2.3	1.3	2.5	2.6
Tanning	0.1	1.1	3.2	1.6	-1.8	-1.0	-0.5	-0.4	-0.5	-0.4
Hand grip strength (left)	0.2	0.5	1.1	-0.3	0.6	0.2	0.9	-0.6	0.7	1.0
Number of treatments/medications taken	1.8	3.3	9.2	-1.7	1.3	1.3	1.4	3.0	1.8	1.4
Average weekly spirits intake	0.8	0.9	1.3	-0.9	1.1	0.3	1.1	0.8	1.1	1.1
Sensitivity / hurt feelings	0.1	0.1	0.3	-0.6	0.2	-0.1	0.3	-0.5	0.1	0.2
Frequency of depressed mood in last 2 weeks	1.1	1.6	2.4	-0.7	-1.6	-1.4	-1.2	1.5	-0.7	-1.4
Hearing difficulty/problems: Yes	0.0	0.0	0.2	0.0	-0.1	0.4	0.1	0.0	0.1	0.2
Relative age of first facial hair	0.2	0.5	1.0	-0.7	0.4	0.3	0.5	0.8	0.8	1.0
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1	0.1	-0.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.2	0.1	-0.1	0.1	0.1	0.4	0.1	-0.3
Ever had hysterectomy (womb removed)	0.4	0.5	1.9	0.6	-0.9	-1.4	-0.3	-0.3	-0.2	-0.1
Systolic blood pressure, automated reading	0.1	0.2	0.7	-0.1	0.6	0.3	0.1	0.8	0.2	0.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.5	0.3	0.2	0.6	-0.2	0.3	0.4
Angina	0.5	0.6	1.2	0.3	-0.8	-0.8	-0.8	-1.1	-1.0	-0.6
Medication for hormone replacement therapy	0.3	0.3	0.5	0.7	-0.7	-0.4	-0.4	0.3	-0.5	-0.7
Vitamin and mineral supplements	0.2	0.2	0.7	0.8	-0.0	-0.1	0.2	-0.8	-0.2	-0.3
Supplements: Zinc	0.6	0.6	2.0	-1.2	-0.2	-0.7	-0.4	1.4	0.1	-0.2
Medication: Co-codamol	0.4	0.5	1.8	0.7	-0.6	-1.3	-0.5	0.6	-0.3	-0.2
Medication: Metformin	3.3	4.6	6.8	-1.6	2.6	1.8	2.4	1.7	2.4	2.4
Diabetes (father)	2.6	3.3	3.8	-2.0	1.9	1.6	1.8	1.6	1.9	1.8
Diabetes (mother)	0.7	0.9	1.4	-1.2	1.1	0.1	1.0	1.0	1.0	0.8
Severe depression (siblings)	0.9	1.0	3.6	-1.9	0.2	0.4	-0.1	1.7	0.4	0.0
Pack years adult smoking proportion	0.4	0.6	1.2	0.2	0.8	0.8	1.1	-0.3	0.8	0.9
Impedance of leg (right)	1.0	4.7	6.3	-2.3	1.8	1.7	2.0	2.3	2.5	2.5
Leg fat-free mass (left)	0.3	1.7	3.3	1.5	-0.6	-1.2	-1.0	-1.2	-1.3	-1.8
Trunk fat percentage	0.7	2.9	7.7	0.3	-1.9	-2.8	-1.8	0.8	-1.4	-1.7
Hand grip strength (right)	0.3	0.9	4.5	1.0	0.3	0.0	0.7	-2.1	0.1	0.6
Townsend deprivation index at recruitment	0.5	0.7	1.6	-0.8	0.9	0.4	1.0	-0.1	0.9	1.2
Current tobacco smoking	0.0	0.1	0.2	0.4	-0.2	-0.0	-0.1	0.3	0.2	0.4
Average weekly fortified wine intake	0.3	0.4	0.7	0.8	-0.6	-0.7	-0.4	-0.9	-0.5	0.0
Maternal smoking around birth	0.8	1.1	3.5	0.4	-1.3	-1.9	-1.0	0.2	-0.7	-1.1
Fed-up feelings	0.8	1.5	3.0	-0.3	-1.0	-1.2	-1.4	1.3	-1.0	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.7	-0.4	-1.6	-1.3	-1.2	1.0	-0.7	-1.3
Relative age voice broke	0.1	0.2	0.4	0.6	-0.6	-0.1	-0.5	0.3	-0.2	-0.2
Taking other prescription medications	1.5	2.3	5.0	-1.6	1.4	1.2	1.3	2.2	1.5	1.0
Age when periods started (menarche)	0.6	1.3	2.5	1.3	-1.0	-0.9	-1.6	-0.7	-1.4	-0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	1.1	-0.9	-0.7	-0.8	0.4	-0.5	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	-0.6	0.6	0.5	1.3	-0.1	1.0	1.0
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.7	-0.9	-0.8	-0.9	-1.3	0.8	-0.8	-1.2
Qualifications: CSEs or equivalent	0.9	1.2	2.2	1.5	-0.9	-1.4	-0.6	-1.2	-1.1	-0.9
Serious illness, injury or assault to yourself	0.5	0.6	1.1	1.1	-0.7	-1.0	-0.8	-0.1	-0.7	-0.8
High blood pressure	0.9	2.5	6.1	-1.7	2.5	1.9	1.1	1.4	1.2	0.9
Hayfever, allergic rhinitis or eczema	1.4	3.1	4.5	-0.7	2.1	1.7	2.1	0.9	2.1	2.1
Multivitamins +/- minerals	0.6	0.8	1.5	0.7	-1.2	-1.2	-1.1	-0.1	-0.8	-0.6
Stomach or abdominal pain in last month	0.5	0.7	3.3	-0.9	0.5	0.3	0.0	1.8	0.4	-0.2
Supplements: Glucosamine	0.1	0.1	0.6	-0.8	0.0	0.0	0.1	0.2	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	-1.0	0.5	-0.0	-0.1	0.7	0.1	-0.3
Medication: Atenolol	0.0	0.0	0.1	-0.1	-0.3	-0.2	0.0	-0.1	-0.1	-0.2
Medication: Levothyroxine sodium	0.6	0.9	1.5	-1.0	1.1	1.2	0.8	1.2	0.8	0.6
Sitting height	0.9	6.6	8.7	-2.7	3.0	2.6	2.2	2.9	2.7	1.9
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.1	0.2	0.0	0.4
High blood pressure (mother)	0.3	0.4	1.0	-0.0	-0.0	-0.8	-0.7	0.7	-0.4	-1.0
Body mass index (BMI)	1.8	7.8	15.0	1.9	-3.1	-3.9	-2.8	-0.8	-2.8	-3.1
Impedance of leg (left)	1.2	6.0	7.5	-2.7	2.1	2.1	2.2	2.6	2.6	2.7
Leg predicted mass (left)	0.3	1.7	3.3	1.5	-0.6	-1.3	-1.1	-1.2	-1.3	-1.8
Trunk fat mass	0.6	2.4	6.4	0.5	-1.6	-2.5	-1.7	0.6	-1.4	-1.7
Waist circumference	0.4	1.6	3.7	0.3	-1.3	-1.9	-1.2	1.1	-0.9	-1.4
Number of incorrect matches in round	5.4	9.0	14.2	-3.8	2.6	3.0	2.7	3.0	3.0	2.9
Past tobacco smoking	5.3	9.7	14.2	1.9	-3.6	-3.1	-3.8	-1.1	-3.5	-3.8
Alcohol usually taken with meals	0.6	1.0	1.9	-1.3	1.4	0.9	0.9	0.5	1.1	0.7
Nervous feelings	0.8	1.4	2.7	-1.0	1.6	1.3	1.0	0.9	1.2	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	-0.9	0.2	-0.3	-0.2	0.8	-0.1	-0.6
Hearing difficulty/problems with background noise	0.3	0.5	0.8	-0.5	0.5	0.7	0.9	-0.6	0.6	0.9
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.2	0.9	0.9	0.6	-0.3	0.4	-0.1
Had menopause	0.2	0.2	0.6	-0.8	0.6	0.5	-0.0	0.3	0.0	-0.3
Had other major operations	0.1	0.1	0.4	0.3	-0.1	-0.4	-0.3	0.6	-0.1	-0.5
Forced vital capacity (FVC)	0.8	3.1	6.0	-0.5	2.0	2.4	2.1	0.1	1.8	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	-0.5	0.6	0.3	1.3	-0.1	1.1	1.1
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.5	0.8	-1.9	-1.7	-1.4	-0.9	-1.5	-1.6
Qualifications: None of the above	0.1	0.2	0.6	-0.1	0.4	0.8	0.5	0.3	0.5	0.5
Financial difficulties in last 2 years	1.7	2.3	4.1	1.3	-1.2	-2.0	-1.8	-0.3	-1.6	-1.7
Mouth/teeth dental problems	0.5	0.7	1.1	0.4	-1.0	-1.1	-1.0	-0.6	-0.8	-0.9
Heart attack	0.3	0.4	0.8	-0.5	0.5	0.9	0.6	0.7	0.7	0.5
Allergy	0.6	1.3	1.8	0.5	-1.3	-1.1	-1.3	-0.8	-1.3	-1.3
Pain all over the body in last month	0.0	0.0	0.1	0.3	0.2	-0.1	0.1	0.2	-0.1	-0.3
Diabetes (self-reported)	1.1	1.7	2.4	-1.0	1.4	1.1	1.6	1.2	1.5	1.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.2	-1.8	1.4	0.8	1.0	1.6	1.2	0.9
Medication: Ramipril	0.2	0.2	0.4	-0.6	-0.3	-0.2	-0.3	0.6	-0.4	-0.6
Medication: Simvastatin	0.3	0.5	1.3	-0.1	0.6	0.7	0.5	1.1	0.8	0.7
Fluid intelligence score	0.2	0.5	0.9	-0.1	-0.6	-0.9	-0.9	-0.4	-0.8	-0.9
Illnesses of siblings	0.5	0.7	3.7	0.7	-0.4	-0.5	-0.1	-1.9	-0.6	-0.1
Neuroticism score	0.1	0.3	0.9	-0.5	1.0	0.6	0.4	0.4	0.4	-0.1
Weight	0.5	2.7	6.0	1.2	-1.4	-2.4	-1.6	-0.1	-1.6	-2.1
Impedance of arm (right)	0.6	2.6	4.2	-1.9	1.1	1.4	1.1	2.0	1.8	1.8
Arm fat percentage (right)	1.9	7.5	15.8	1.4	-3.2	-4.0	-2.9	-0.0	-2.6	-3.0
Trunk fat-free mass	0.2	1.0	2.3	1.4	-0.2	-0.6	-0.7	-1.0	-0.9	-1.5
Hip circumference	0.7	3.0	6.4	0.8	-1.5	-2.5	-1.9	0.7	-1.6	-2.2
Time employed in main current job	0.1	0.1	0.5	0.1	-0.4	-0.1	-0.4	0.7	-0.1	0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.1	0.6	0.6	0.3	0.4	0.3	0.4
Father’s age at death	0.9	1.2	2.6	-0.2	1.2	1.1	1.6	-0.8	1.1	1.1
Worrier / anxious feelings	0.2	0.3	1.2	0.0	0.8	1.1	-0.2	-0.2	-0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	6.4	0.4	-2.1	-2.3	-2.3	1.3	-1.8	-2.5
Falls in the last year	1.6	2.1	5.1	0.8	-1.4	-2.3	-1.5	-0.6	-1.4	-1.5
Hair/balding pattern: Pattern 3	0.7	1.1	2.2	-0.1	-1.4	-1.5	-0.9	-0.8	-1.2	-0.8
Number of live births	0.7	1.0	2.1	0.6	-0.6	-1.4	-1.2	-0.4	-1.0	-1.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.9	0.2	0.7	0.7	0.5	-0.9	0.2	0.3
Pulse rate	0.9	1.5	2.3	-1.3	1.4	1.5	0.7	1.5	1.0	0.7
Happiness	0.4	0.5	1.2	0.1	-0.3	-1.1	-0.9	-0.2	-0.7	-1.1
Noisy workplace	0.1	0.1	0.5	-0.4	-0.7	-0.5	-0.1	0.1	-0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	0.5	-0.2	-0.1	-0.1	-0.3	-0.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.5	1.4	-0.9	-1.6	-1.0	-1.3	-1.3	-1.2
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	0.1	-0.4	-0.0	0.1	0.4	0.3	0.3
Asthma	0.0	0.1	0.3	-0.2	0.4	0.6	0.1	-0.3	-0.1	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.2	-0.3	0.0	-0.3
Medication: Cholesterol lowering	0.5	0.7	1.3	-0.4	1.0	1.1	0.9	0.5	0.9	0.8
Depression (self-reported)	1.5	1.8	2.9	-1.1	1.5	0.7	1.7	1.1	1.6	1.5
Medication: Lansoprazole	1.3	1.4	5.1	-0.7	0.6	0.8	0.9	2.3	1.3	0.9
Prospective memory result	0.1	0.1	0.3	0.4	-0.5	-0.0	0.0	-0.3	-0.2	-0.2
Lung cancer (father)	1.4	1.6	2.1	1.4	-1.2	-1.3	-1.1	-1.2	-1.2	-1.4
Illnesses of mother	1.2	1.4	2.6	0.5	-1.5	-1.1	-1.2	-1.6	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	0.1	0.6	0.6	0.6	-0.6	0.4	0.3
Pulse wave Arterial Stiffness index	1.2	1.4	1.8	-1.2	1.2	1.2	1.4	1.0	1.2	1.1
Impedance of arm (left)	1.0	4.5	6.2	-2.4	1.6	2.0	1.7	2.5	2.3	2.3
Arm fat mass (right)	1.6	6.7	13.4	1.7	-2.8	-3.7	-2.7	-0.5	-2.5	-3.0
Trunk predicted mass	0.2	1.1	2.6	1.4	-0.2	-0.8	-0.8	-1.0	-1.0	-1.6
Standing height	0.6	5.7	11.2	-1.3	3.3	2.8	2.6	1.4	2.6	2.1
Length of working week for main job	1.5	1.7	2.5	1.0	-1.6	-1.6	-1.5	-0.6	-1.3	-1.3
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.3	0.5	0.0	0.3	0.3	0.2	0.2
Breastfed as a baby	0.8	1.0	2.2	1.5	-1.2	-0.8	-0.5	-1.0	-0.8	-0.7
Tense / ‘highly strung’	2.2	3.6	4.7	-1.8	2.1	2.1	2.2	0.6	2.0	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.5	0.2	0.2	0.7	-0.7	0.2	0.0
Hair/balding pattern: Pattern 4	0.4	0.8	2.1	0.1	1.1	1.4	1.0	0.1	1.0	0.8
Birth weight of first child	2.8	5.2	7.3	2.5	-1.9	-2.7	-2.1	-2.3	-2.4	-2.1
Peak expiratory flow (PEF)	1.0	2.4	3.7	-1.4	1.7	1.4	1.8	0.3	1.7	1.9
Pulse wave reflection index	0.1	0.2	0.5	-0.4	-0.4	-0.1	0.4	0.7	0.4	0.4
Ever highly irritable/argumentative for 2 days	2.6	3.1	4.8	0.9	-2.0	-2.1	-2.2	0.3	-1.8	-2.1
Loud music exposure frequency	0.4	0.5	2.3	0.6	0.0	-0.5	-0.1	-1.5	-0.5	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.6	-0.1	0.1	0.1	0.1	-0.8	0.0	0.1
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.3	-1.1	1.8	1.6	1.7	0.3	1.3	1.4
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.3	-0.5	0.3	0.2	0.5	0.2	-0.1
Medication: Paracetamol	0.3	0.5	0.9	0.6	-0.7	-0.9	-0.8	-0.5	-0.7	-0.4
Headache pain in last month	0.2	0.3	1.7	-0.2	-0.1	0.2	-0.0	1.3	0.2	-0.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	1.8	1.2	-1.3	-1.3	-0.8	-1.3	-1.1	-1.0
Glaucoma (self-reported)	0.7	0.8	1.3	1.0	-0.4	-0.6	-1.1	-0.8	-1.1	-1.1
Gout (self-reported)	0.2	0.3	0.9	-0.7	-0.2	0.3	0.7	0.1	0.6	0.9
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.0	-1.4	1.3	1.1	1.3	1.1	1.2	1.0
Medication: Amlodipine	0.6	0.8	1.2	0.8	-0.5	-0.5	-1.0	-1.1	-1.1	-1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.7	1.6	-0.6	-0.6	-0.6	-1.9	-1.1	-0.6
Birth weight	0.5	1.1	4.6	1.6	0.3	0.2	-0.1	-2.1	-0.7	-0.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	3.9	-0.5	-0.3	-0.3	0.2	2.0	0.5	0.4
High blood pressure (siblings)	0.4	0.6	1.4	0.5	-0.3	-1.0	-0.7	1.2	-0.5	-1.0
Forced vital capacity (FVC), Best measure	0.8	3.0	4.4	-0.9	1.9	2.1	2.1	0.8	1.9	1.8
Body fat percentage	0.9	3.5	9.1	0.4	-2.2	-3.0	-2.0	0.7	-1.6	-1.9
Leg fat percentage (right)	1.1	4.1	11.3	0.6	-2.3	-3.4	-2.1	0.3	-1.8	-2.1
Arm fat-free mass (right)	0.2	0.9	2.0	1.3	-0.2	-0.8	-0.7	-0.6	-0.9	-1.4
Exposure to tobacco smoke outside home	0.8	1.1	1.5	0.9	-0.8	-1.2	-1.1	-0.7	-1.2	-1.2
Comparative body size at age 10	0.1	0.3	1.1	0.2	-0.4	-0.1	-0.3	1.1	-0.3	-0.5
Number of full brothers	1.7	2.2	3.8	0.6	-1.9	-1.7	-1.9	0.4	-1.5	-1.4
Worry too long after embarrassment	0.1	0.1	0.4	0.3	0.6	0.4	0.3	-0.1	0.3	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.1	0.2	0.7	0.9	1.1	-0.9	0.7	0.8
Wheeze or whistling in the chest in last year	0.0	0.1	0.3	0.1	-0.3	-0.5	-0.1	0.3	-0.0	0.0
Number of children fathered	0.7	0.8	1.6	1.1	-0.3	-1.3	-0.8	-0.9	-0.9	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.3	-0.6	1.1	1.6	1.8	0.6	1.6	1.7
Age at first live birth	0.3	0.5	0.8	0.7	-0.9	-0.1	-0.7	-0.8	-0.9	-0.6
Pulse wave peak to peak time	1.0	1.2	1.5	1.1	-1.1	-1.1	-1.2	-0.8	-1.1	-1.1
Health satisfaction	1.4	1.8	3.6	0.5	-1.2	-1.6	-1.6	0.5	-1.4	-1.9
Shortness of breath walking on level ground	2.2	2.6	4.9	1.3	-2.2	-1.9	-1.7	-1.0	-1.6	-1.3
Qualifications: College or University degree	0.1	0.4	1.0	-0.1	0.1	-0.2	-0.8	-0.3	-0.8	-1.0
Eye problems/disorders: None of the above	0.4	0.5	1.0	-1.0	0.6	0.5	0.5	0.6	0.7	0.9
Mouth/teeth dental problems: Loose teeth	1.9	2.3	3.1	1.4	-1.6	-1.6	-1.6	-0.9	-1.6	-1.8
Emphysema/chronic bronchitis	0.2	0.2	0.8	-0.3	-0.3	-0.5	-0.4	0.9	-0.1	0.0
Medication for pain relief, constipation, heartburn	1.0	1.7	2.5	-1.3	1.2	1.4	1.4	0.5	1.4	1.6
Neck or shoulder pain in last month	0.3	0.5	0.9	-1.0	0.8	0.5	0.7	0.5	0.6	0.6
Medication: Blood pressure	0.1	0.3	0.8	-0.4	0.9	0.9	0.2	-0.0	0.1	0.2
Angina (self-reported)	0.4	0.6	1.3	0.3	-0.7	-0.8	-0.7	-1.1	-0.9	-0.5
Migraine (self-reported)	0.3	0.4	1.5	1.1	-0.4	-0.1	-0.0	-1.2	-0.2	-0.1
Medication: Ibuprofen	0.2	0.2	0.6	0.3	-0.2	-0.5	-0.1	-0.7	-0.3	-0.6
Medication: Allopurinol	0.4	0.5	1.0	0.2	-1.0	-1.0	-0.5	-0.6	-0.7	-0.4
Medication: Omeprazole	0.3	0.3	1.2	0.4	-0.3	-0.3	-0.5	1.1	-0.3	-0.7
Medication: Seretide 50 evohaler	2.4	2.7	5.4	1.5	-1.8	-1.7	-1.1	-2.3	-1.7	-1.0
Mean time to correctly identify matches	0.2	0.4	1.7	-0.1	-0.0	0.1	-0.5	1.3	-0.2	-0.7
Heart disease (mother)	0.1	0.2	0.5	0.7	-0.7	-0.1	0.0	-0.4	-0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.8	-0.3	0.5	1.3	1.0	0.5	1.1	1.4
Whole body fat mass	0.7	2.7	6.7	0.8	-1.7	-2.6	-1.7	0.2	-1.6	-1.9
Leg fat mass (right)	0.9	3.4	8.9	0.9	-1.9	-3.0	-1.8	-0.1	-1.7	-2.1
Arm predicted mass (right)	0.2	1.0	2.3	1.2	-0.4	-0.9	-0.7	-0.8	-1.0	-1.5
Pulse rate, automated reading	0.9	2.8	6.0	-1.5	1.5	1.2	1.4	2.5	1.7	1.6
Alcohol intake frequency.	0.2	0.4	0.8	0.6	-0.5	-0.5	-0.8	0.9	-0.5	-0.4
Comparative height size at age 10	1.1	6.0	7.4	-2.1	2.7	2.5	2.4	2.3	2.6	2.3
Number of full sisters	0.5	0.6	2.5	-1.3	-0.4	0.0	0.1	1.6	0.4	0.2
Suffer from ‘nerves’	0.5	0.8	1.3	-0.7	1.1	0.9	1.1	0.4	1.0	0.9
Overall health rating	0.4	0.8	3.5	-1.3	0.3	0.0	0.2	1.9	0.4	-0.0
Chest pain or discomfort	5.6	8.1	11.3	1.7	-3.1	-3.4	-3.1	-1.5	-3.1	-3.3
Had major operations	0.4	0.5	1.0	-0.8	1.0	0.5	0.6	-0.5	0.5	0.8
Age at last live birth	0.1	0.1	0.2	0.2	-0.3	0.1	-0.3	-0.4	-0.3	-0.3
Family relationship satisfaction	2.8	3.4	4.8	1.5	-1.9	-2.2	-2.0	-1.3	-2.0	-1.9
Leg pain on walking	0.3	0.4	0.7	0.1	-0.7	-0.8	-0.6	-0.0	-0.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.9	-1.0	0.7	0.8	1.5	1.1	1.5	1.7
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.5	1.3	-1.3	-1.9	-1.0	-1.1	-1.2	-1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.1	-1.2	0.8	1.4	0.6	0.8	0.8	0.6
Medication: Aspirin	0.2	0.2	0.6	-0.8	0.1	-0.0	0.3	0.8	0.4	0.3
Supplements: Vitamin C	0.2	0.2	0.8	-0.3	-0.0	0.2	-0.5	0.9	-0.2	-0.4
Knee pain experienced in last month	0.3	0.4	0.9	-0.2	0.6	0.1	0.7	0.7	0.8	0.9
Hypertension (Self-reported)	0.7	2.1	5.5	-1.6	2.3	1.6	0.9	1.3	1.0	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	5.7	-0.8	0.3	0.3	-0.0	2.4	0.4	-0.2
Illnesses of father: Heart disease	0.3	0.4	0.9	0.4	-0.6	-0.8	-1.0	0.4	-0.7	-0.6
Illnesses of siblings: Diabetes	0.4	0.5	1.1	-0.1	0.9	0.4	1.1	0.3	0.9	0.9
Smoking status: Previous	6.0	9.0	13.5	-1.8	3.5	3.0	3.7	0.9	3.3	3.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	-0.2	1.0	0.4	0.8	-0.2	0.6	0.7
Whole body fat-free mass	0.2	1.2	2.6	1.4	-0.3	-0.9	-0.8	-1.0	-1.1	-1.6
Leg fat-free mass (right)	0.3	1.4	2.8	1.4	-0.5	-1.0	-1.0	-1.1	-1.3	-1.7
Arm fat percentage (left)	1.6	6.5	13.8	1.1	-3.0	-3.7	-2.8	0.3	-2.4	-2.8
Average weekly red wine intake	0.1	0.2	0.5	0.7	0.2	-0.5	-0.1	-0.6	-0.1	-0.2
Handedness (chirality/laterality): Left-handed	1.5	1.7	2.6	1.3	-1.6	-1.6	-1.2	-0.7	-1.3	-1.4
Mood swings	0.2	0.3	0.9	-0.7	0.8	0.2	0.1	0.9	0.3	-0.1
Loneliness, isolation	0.4	0.5	2.8	-0.2	-0.1	0.1	-0.4	1.7	-0.1	-0.8
Long-standing illness, disability or infirmity	0.3	0.5	1.1	-0.8	1.1	0.3	0.6	0.8	0.7	0.5
Ever had bowel cancer screening	0.7	0.8	1.7	0.5	-1.3	-1.2	-0.9	-0.4	-0.8	-0.6
Diabetes diagnosed by doctor	0.9	1.6	2.8	-1.3	1.2	0.6	1.2	1.7	1.3	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.4	0.3	-0.3	-0.5	-0.7	1.2	-0.3	-0.6
Friendships satisfaction	0.3	0.3	1.0	0.2	-0.7	-1.0	-0.3	0.5	-0.2	-0.7
Qualifications: nursing, teaching	1.2	1.9	4.8	0.8	-1.6	-2.2	-1.2	-0.9	-1.2	-1.2
Commuting to job workplace: Walk	3.2	3.4	7.6	-1.1	2.2	2.8	1.7	1.1	1.9	1.6
Eye problems/disorders: Cataract	1.5	1.7	2.8	1.0	-1.0	-1.4	-1.5	-0.8	-1.5	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.2	-1.1	1.5	1.3	1.1	0.5	1.0	0.7
Medication for cholesterol	0.3	0.5	2.2	-0.4	0.5	0.5	0.5	-1.5	0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.3	0.4	-0.0	-0.1	0.3	0.1	-0.2
Back pain experienced in last month	0.1	0.1	0.3	0.5	0.0	0.3	0.3	0.2	0.2	0.1
Mineral and other dietary supplements	0.1	0.1	0.2	0.4	0.3	-0.2	-0.2	-0.3	-0.3	-0.5
Breast cancer (self-reported)	0.4	0.4	1.3	1.2	0.5	0.2	0.3	-1.1	-0.2	0.2
Asthma (self-reported)	0.0	0.0	0.1	-0.2	0.2	0.3	-0.1	-0.2	-0.2	-0.1
Osteoporosis (self-reported)	2.5	3.1	5.0	-0.9	1.8	1.9	2.0	1.1	2.1	2.2
Osteoarthritis (self-reported)	0.1	0.1	0.4	0.1	0.6	0.5	0.4	-0.0	0.2	0.0
Medication: Aspirin	0.2	0.2	0.6	-0.7	0.4	0.1	0.2	0.7	0.4	0.2
Medication: Gliclazide	0.6	0.7	1.8	-1.2	0.6	-0.5	0.5	1.3	0.7	0.6
Illnesses of father: None of the above (group 1)	1.0	1.3	2.5	1.5	-1.2	-0.5	-0.9	-1.6	-0.9	-0.9
Smoking status: Current	0.1	0.2	0.4	0.1	0.2	0.2	0.2	0.5	0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.2	0.1	0.0	0.1	-0.0	-0.5	-0.1	0.1
Whole body water mass	0.2	1.3	2.8	1.5	-0.3	-0.9	-0.8	-1.1	-1.1	-1.7
Leg predicted mass (right)	0.2	1.3	2.7	1.4	-0.4	-1.0	-0.9	-1.1	-1.2	-1.6
Arm fat mass (left)	1.3	5.3	10.8	1.4	-2.5	-3.3	-2.4	-0.0	-2.2	-2.7
Number of self-reported non-cancer illnesses	0.7	1.2	2.4	-0.8	1.3	1.1	0.8	1.6	1.0	0.7
Average weekly champagne plus white wine intake	1.1	1.5	2.6	-1.6	1.1	1.1	0.8	1.6	1.1	0.9
Miserableness	0.2	0.3	0.9	0.4	-0.5	-0.4	-0.7	0.4	-0.6	-0.9
Guilty feelings	0.2	0.4	0.9	-0.0	1.0	0.8	0.7	-0.0	0.5	0.5
Wears glasses or contact lenses	0.3	0.4	1.0	0.1	1.0	0.9	0.7	-0.3	0.4	0.5
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.7	0.8	0.4	0.7	-0.2	0.5	0.5
Hearing aid user	0.5	0.5	0.8	-0.7	0.9	0.6	0.9	-0.0	0.9	0.8
Mother’s age at death	2.3	2.9	4.8	-1.2	1.4	2.2	2.1	0.7	1.9	1.8
Financial situation satisfaction	2.8	3.5	6.2	0.9	-1.7	-2.3	-2.1	-0.9	-2.0	-2.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.6	0.4	0.0	-0.1	0.1	-1.2	-0.2	0.6
Commuting to job workplace: Public transport	0.2	0.3	0.7	-0.0	0.5	0.8	-0.4	0.5	-0.3	-0.5
Eye problems/disorders: Glaucoma	1.0	1.2	2.4	1.5	-0.5	-0.5	-1.0	-1.5	-1.1	-1.1
Medication: Blood pressure	0.3	0.5	1.9	-1.0	0.5	0.3	0.3	1.4	0.4	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	0.1	0.2	-0.0	0.5	-0.6	0.2	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.2	-0.6	-0.0	-0.3	0.1	-0.0	0.1
High cholesterol (Self-reported)	0.6	1.1	2.8	0.8	1.2	1.7	0.9	0.3	1.0	1.1
Medication: Bendroflumethiazide	0.5	0.7	1.3	-0.9	1.1	1.0	0.6	0.4	0.7	1.1
Medication: Paracetamol	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.1	-0.4	-0.1	0.2
Medication: Lisinopril	1.5	2.0	4.5	-0.6	2.1	1.5	1.1	1.5	1.4	1.2
Medication: Atorvastatin	0.2	0.3	0.7	0.1	0.9	0.5	0.6	0.3	0.5	0.7
Illnesses of father: High blood pressure	0.9	1.1	1.6	-1.2	1.2	1.1	1.1	0.8	0.9	0.8
Alcohol drinker status: Never	0.1	0.2	0.7	0.2	-0.3	-0.9	-0.3	0.3	-0.1	-0.1
Ever smoked	4.1	7.1	10.6	-1.5	3.3	2.6	3.2	1.1	3.0	3.2
Basal metabolic rate	0.3	1.9	3.8	1.6	-0.8	-1.4	-1.2	-1.0	-1.4	-2.0
Leg fat percentage (left)	1.1	3.9	10.4	0.4	-2.2	-3.2	-2.1	0.2	-1.9	-2.0
Arm fat-free mass (left)	0.3	1.7	3.9	1.3	-0.7	-1.4	-1.2	-0.8	-1.4	-2.0
Number of operations (self-reported)	0.4	0.6	2.0	1.0	0.0	-0.9	-0.4	-1.4	-0.6	-0.3
Average weekly beer plus cider intake	1.0	1.4	5.0	1.3	-1.3	-0.3	-0.5	-2.2	-1.0	-0.3
Irritability	1.3	2.2	3.9	-1.7	1.3	1.6	1.1	2.0	1.4	1.1
Risk taking	0.6	0.8	1.6	1.1	-1.3	-0.8	-0.9	-0.1	-0.8	-0.9
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	1.3	-1.1	-1.2	-0.7	-0.5	-0.6	-0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.8	0.7	0.1	-0.2	-0.4	-0.7	-0.5	-0.9
Age started oral contraceptive pill	0.6	0.7	1.6	1.2	-0.7	-0.1	-0.6	-1.3	-0.8	-0.8
Diastolic blood pressure, automated reading	1.2	3.6	6.2	1.7	-1.5	-2.5	-2.2	0.2	-2.0	-2.2
Ever depressed for a whole week	1.1	1.4	2.8	-0.1	-1.6	-1.7	-1.3	-0.3	-1.1	-1.2
Unable to work because of sickness or disability	0.3	0.4	1.1	0.6	-0.8	-1.0	-0.6	-0.2	-0.5	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.6	0.2	-0.0	-0.2	0.0	-0.1	-0.4
Myopia	0.6	0.9	3.3	1.1	-0.4	-0.6	-0.3	-1.8	-0.8	-0.3
Vascular/heart problems diagnosed by doctor	1.5	4.0	9.3	1.8	-3.0	-2.4	-1.7	-1.4	-1.7	-1.4
Cholesterol lowering medication	0.1	0.2	1.0	1.0	-0.1	0.1	0.1	0.3	0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.7	0.0	0.7	0.8	0.6	1.6	0.8	0.5
Pain experienced in last month	0.2	0.3	0.8	0.0	-0.6	-0.4	-0.9	-0.3	-0.7	-0.7
Supplements: Calcium	0.9	1.0	2.1	-1.5	0.2	0.3	1.0	1.1	1.1	1.1
Basal cell carcinoma (self-reported)	1.5	1.8	2.3	1.3	-1.4	-1.4	-1.4	-1.2	-1.5	-1.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.5	0.6	0.9	0.7	0.6	0.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	-0.3	-0.4	0.4	0.3	0.6	0.2	-0.1
Heart disease (siblings)	0.2	0.3	0.6	0.4	-0.7	-0.2	-0.8	-0.1	-0.5	-0.6
Alcohol drinker status: Previous	0.9	1.1	1.6	0.6	-1.3	-1.3	-1.2	-0.1	-1.1	-1.0
Pack years of smoking	1.0	1.5	2.7	-0.5	1.4	1.4	1.6	0.3	1.4	1.4
Impedance of whole body	1.2	6.2	8.4	-2.9	2.0	2.1	2.0	2.9	2.6	2.7
Leg fat mass (left)	0.8	3.0	7.6	0.7	-1.8	-2.8	-1.7	0.0	-1.7	-2.0
Arm predicted mass (left)	0.4	2.0	4.1	1.6	-0.8	-1.4	-1.2	-1.1	-1.5	-2.0