Hub : Genes

ZNF382

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1330 0.0450 4.1e-12 0.052 0.110 0.095 0.11 0.093 6.0e-07 2.9e-13 1.4e-11 3.1e-13 2.1e-11
2 GTEx Brain Cerebellar Hemisphere 0.2280 0.1120 2.1e-03 0.142 NA 0.046 NA 0.117 1.8e-04 NA 2.5e-02 NA 6.5e-04
3 GTEx Brain Cerebellum 0.2350 0.0700 1.7e-06 0.212 NA 0.230 NA 0.239 6.6e-07 NA 2.0e-07 NA 1.1e-07
4 TCGA Brain Lower Grade Glioma 0.0682 0.0413 5.6e-04 0.025 0.009 0.002 NA 0.012 7.3e-04 2.8e-02 1.9e-01 NA 1.3e-02
5 TCGA Ovarian Serous Cystadenocarcinoma 0.0350 0.0260 8.1e-03 0.020 0.027 0.015 NA 0.015 1.5e-02 6.1e-03 3.0e-02 NA 3.1e-02
6 TCGA Prostate Adenocarcinoma 0.0714 0.0341 5.1e-07 0.073 0.068 0.070 NA 0.074 4.1e-08 1.2e-07 7.6e-08 NA 3.7e-08
7 TCGA Thyroid Carcinoma 0.0440 0.0250 3.7e-04 0.036 0.032 0.033 NA 0.035 1.7e-04 3.7e-04 3.4e-04 NA 2.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.5 2.4 3.5 1.6 -1.4 -1.9 -1.3 -1.8 -1.5 -1.1
Bipolar Disorder or Schizophrenia 1.5 3.8 7.0 2.1 -1.8 -1.7 -1.6 -2.7 -1.9 -1.5
Depressed Affect (Nagel 2018) 0.4 0.7 1.8 0.4 -0.5 -0.8 -1.0 1.0 -0.7 -1.4
Depression (Nagel 2018) 1.3 1.9 4.8 0.5 -2.2 -1.3 -1.4 0.9 -1.0 -1.6
Intelligence (Savage-Jansen 2018) 2.5 7.7 10.3 1.2 -3.2 -3.2 -3.2 -1.9 -3.0 -3.0
Neuroticism (Nagel 2018) 0.2 0.6 1.3 -0.4 1.1 1.0 0.6 0.8 0.7 0.3
Schizophrenia (2018) 0.8 1.6 3.8 1.4 -1.2 -0.7 -1.0 -1.9 -1.2 -1.0
Schizophrenia vs Biploar Disorder 0.1 0.1 0.3 0.1 0.1 0.2 -0.2 -0.5 -0.4 -0.6
Worry (Nagel 2018) 0.9 1.9 3.5 -1.1 1.9 1.8 1.4 0.2 1.3 1.2
Alzheimer’s Disease (in mother) 0.4 0.5 1.3 0.9 -0.2 -1.2 -0.3 -0.9 -0.3 -0.2
Alzheimer’s Disease (in father) 0.0 0.1 0.1 -0.2 -0.0 -0.1 -0.2 0.3 -0.2 -0.4
Alzheimer’s Disease (including proxy) 0.5 0.7 1.7 0.9 -0.5 -1.3 -0.3 -1.2 -0.7 -0.6
Crohns Disease (2017) 0.5 1.1 1.8 -0.5 1.2 1.2 1.3 0.2 1.1 1.3
Irritable Bowel Disease (IBD) 0.6 1.5 2.9 -0.7 1.3 1.7 1.5 0.8 1.3 0.8
Ulcerative Colitis (UC) 0.1 0.2 0.5 0.1 0.1 0.7 0.3 0.6 0.2 -0.6
Major Depression (MDD) 0.8 0.9 4.5 -1.3 -0.0 -0.4 0.0 2.1 0.3 -0.1
Reaction Time 0.3 0.6 2.8 -0.3 0.0 -0.1 -0.8 1.7 -0.3 -0.9
Verbal and Numeric Reasoning (VNR) 1.2 2.8 3.5 0.8 -1.9 -1.8 -1.9 -1.5 -1.9 -1.8
Breast Cancer 0.1 0.3 0.9 -0.7 0.3 0.4 0.4 0.9 0.6 0.3
Ovarian Cancer 2.8 3.7 4.9 -1.6 1.9 1.5 1.8 2.1 2.2 2.2
Prostate Cancer 0.2 0.2 0.8 0.9 -0.4 0.4 0.3 -0.6 0.0 0.1
Age at First Birth 0.2 0.2 0.6 -0.3 -0.6 -0.5 -0.8 0.0 -0.5 -0.4
Bipolar Disorder (2011) 5.2 5.1 6.9 2.4 -2.3 -2.6 -2.0 -2.5 -2.1 -1.7
Body Mass Index (BMI) (2010) 0.7 1.0 1.3 1.0 -1.0 -0.9 -1.0 -0.6 -1.1 -1.1
Coronary Artery Disease (CAD) 0.2 0.3 0.9 0.4 -0.2 -0.3 -0.5 0.5 -0.3 -1.0
Crohns Disease (2012) 0.2 0.2 0.9 1.0 0.0 -0.5 -0.4 -0.3 -0.5 -0.2
Mean Putamen Volume 2.1 2.4 4.2 1.0 -1.3 -1.9 -2.1 0.2 -1.6 -1.9
Fasting Glucose 1.9 2.3 3.7 1.9 -1.1 -1.8 -1.3 -1.0 -1.4 -1.8
HbA1C 0.3 0.3 0.7 0.5 0.8 0.5 0.5 0.2 0.5 0.6
HDL Cholesterol 1.1 1.8 3.1 -1.2 1.3 1.1 1.7 0.3 1.4 1.8
LDL Cholesterol 0.3 0.4 0.8 -0.4 0.8 0.6 0.6 0.9 0.6 0.5
Lupus 0.3 0.5 1.6 -0.5 1.3 0.9 0.7 0.1 0.5 0.3
Neuroticism (2016) 0.5 0.7 2.4 -0.8 0.5 0.7 0.6 1.6 0.8 0.5
Primary Biliary Cirrhosis 1.7 2.5 4.8 -0.0 2.0 2.2 1.8 0.3 1.6 1.7
Rheumatoid Arthritis 2.0 2.7 3.6 1.7 -1.7 -1.5 -1.9 -0.8 -1.9 -1.7
Schizophrenia (2014) 0.6 1.2 4.6 1.1 -0.9 -0.3 -0.6 -2.1 -1.0 -0.6
Triglycerides 0.3 0.5 1.1 0.0 -1.0 -0.7 -0.8 0.8 -0.5 -0.6
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.1 0.2 -0.6 -1.1 -0.8 -0.7 -0.8 -0.8
Ulcerative Colitis 0.6 0.9 3.0 -0.3 0.9 1.7 1.0 0.7 0.7 0.1
Blood Eosinophil Count 0.0 0.1 0.4 0.6 0.3 -0.4 -0.3 -0.1 -0.2 0.1
Blood Platelet Count 2.4 27.7 33.8 5.4 -4.8 -5.0 -5.1 -5.4 -5.8 -5.3
Blood Red Count 0.2 1.9 9.5 -1.8 0.3 -0.1 -0.4 3.1 0.2 -0.4
Blood White Count 1.4 10.5 16.8 1.9 -4.1 -3.4 -3.6 -2.2 -3.6 -3.1
Heel T-Score 0.0 0.2 1.5 -1.2 -0.3 -0.1 0.2 0.1 0.1 -0.3
BMI 1.1 6.2 12.2 1.9 -2.6 -3.5 -2.5 -0.9 -2.5 -2.8
Height 0.2 3.0 9.0 0.1 3.0 2.3 1.6 0.1 1.7 1.3
Waist Hip Ratio (WHR) 0.2 0.7 1.1 -0.6 0.7 1.1 0.9 0.9 0.8 1.0
Systolic Blood Pressure 0.2 1.2 3.5 -0.1 1.9 1.4 1.1 0.7 1.0 0.8
Smoking Status 1.8 4.3 7.1 -0.8 2.7 2.3 2.3 0.4 2.2 2.6
Allergy or Eczema 1.4 3.7 5.7 -0.9 2.0 1.8 2.2 1.3 2.4 2.4
Cardiovascular Disease 0.8 2.6 6.0 -1.5 2.4 1.8 1.1 1.7 1.3 1.1
Hypothyroidism (self reported) 2.7 6.3 8.6 -2.9 2.3 2.4 2.5 2.4 2.6 2.4
Respiratory disease 0.1 0.1 0.2 -0.4 0.4 0.4 0.2 0.4 0.2 0.5
Type 2 Diabetes (T2D) (2018) 1.4 2.7 4.2 -1.7 1.6 1.1 1.6 2.0 1.7 1.6
Lung FEV1/FVC ratio 4.3 21.7 27.7 3.4 -4.3 -5.0 -5.1 -4.0 -5.3 -5.2
Lung FVC 0.6 3.2 7.0 -1.1 0.8 2.6 1.7 1.8 1.8 2.0
Neuroticism 0.2 0.4 1.1 -0.4 1.0 0.9 0.5 0.2 0.5 -0.0
Chronotype (morning person) 2.7 6.2 9.6 -0.5 3.1 3.0 3.0 -0.6 2.4 3.0
Hair Pigment 0.1 4.2 7.0 -1.2 2.0 1.9 2.3 1.3 2.5 2.6
Tanning 0.1 1.1 3.2 1.6 -1.8 -1.0 -0.5 -0.4 -0.5 -0.4
Hand grip strength (left) 0.2 0.5 1.1 -0.3 0.6 0.2 0.9 -0.6 0.7 1.0
Number of treatments/medications taken 1.8 3.3 9.2 -1.7 1.3 1.3 1.4 3.0 1.8 1.4
Average weekly spirits intake 0.8 0.9 1.3 -0.9 1.1 0.3 1.1 0.8 1.1 1.1
Sensitivity / hurt feelings 0.1 0.1 0.3 -0.6 0.2 -0.1 0.3 -0.5 0.1 0.2
Frequency of depressed mood in last 2 weeks 1.1 1.6 2.4 -0.7 -1.6 -1.4 -1.2 1.5 -0.7 -1.4
Hearing difficulty/problems: Yes 0.0 0.0 0.2 0.0 -0.1 0.4 0.1 0.0 0.1 0.2
Relative age of first facial hair 0.2 0.5 1.0 -0.7 0.4 0.3 0.5 0.8 0.8 1.0
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.1 0.2 0.2 -0.2 -0.1 0.1 -0.2 -0.2
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.2 0.1 -0.1 0.1 0.1 0.4 0.1 -0.3
Ever had hysterectomy (womb removed) 0.4 0.5 1.9 0.6 -0.9 -1.4 -0.3 -0.3 -0.2 -0.1
Systolic blood pressure, automated reading 0.1 0.2 0.7 -0.1 0.6 0.3 0.1 0.8 0.2 0.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.5 0.3 0.2 0.6 -0.2 0.3 0.4
Angina 0.5 0.6 1.2 0.3 -0.8 -0.8 -0.8 -1.1 -1.0 -0.6
Medication for hormone replacement therapy 0.3 0.3 0.5 0.7 -0.7 -0.4 -0.4 0.3 -0.5 -0.7
Vitamin and mineral supplements 0.2 0.2 0.7 0.8 -0.0 -0.1 0.2 -0.8 -0.2 -0.3
Supplements: Zinc 0.6 0.6 2.0 -1.2 -0.2 -0.7 -0.4 1.4 0.1 -0.2
Medication: Co-codamol 0.4 0.5 1.8 0.7 -0.6 -1.3 -0.5 0.6 -0.3 -0.2
Medication: Metformin 3.3 4.6 6.8 -1.6 2.6 1.8 2.4 1.7 2.4 2.4
Diabetes (father) 2.6 3.3 3.8 -2.0 1.9 1.6 1.8 1.6 1.9 1.8
Diabetes (mother) 0.7 0.9 1.4 -1.2 1.1 0.1 1.0 1.0 1.0 0.8
Severe depression (siblings) 0.9 1.0 3.6 -1.9 0.2 0.4 -0.1 1.7 0.4 0.0
Pack years adult smoking proportion 0.4 0.6 1.2 0.2 0.8 0.8 1.1 -0.3 0.8 0.9
Impedance of leg (right) 1.0 4.7 6.3 -2.3 1.8 1.7 2.0 2.3 2.5 2.5
Leg fat-free mass (left) 0.3 1.7 3.3 1.5 -0.6 -1.2 -1.0 -1.2 -1.3 -1.8
Trunk fat percentage 0.7 2.9 7.7 0.3 -1.9 -2.8 -1.8 0.8 -1.4 -1.7
Hand grip strength (right) 0.3 0.9 4.5 1.0 0.3 0.0 0.7 -2.1 0.1 0.6
Townsend deprivation index at recruitment 0.5 0.7 1.6 -0.8 0.9 0.4 1.0 -0.1 0.9 1.2
Current tobacco smoking 0.0 0.1 0.2 0.4 -0.2 -0.0 -0.1 0.3 0.2 0.4
Average weekly fortified wine intake 0.3 0.4 0.7 0.8 -0.6 -0.7 -0.4 -0.9 -0.5 0.0
Maternal smoking around birth 0.8 1.1 3.5 0.4 -1.3 -1.9 -1.0 0.2 -0.7 -1.1
Fed-up feelings 0.8 1.5 3.0 -0.3 -1.0 -1.2 -1.4 1.3 -1.0 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.7 -0.4 -1.6 -1.3 -1.2 1.0 -0.7 -1.3
Relative age voice broke 0.1 0.2 0.4 0.6 -0.6 -0.1 -0.5 0.3 -0.2 -0.2
Taking other prescription medications 1.5 2.3 5.0 -1.6 1.4 1.2 1.3 2.2 1.5 1.0
Age when periods started (menarche) 0.6 1.3 2.5 1.3 -1.0 -0.9 -1.6 -0.7 -1.4 -0.9
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.2 1.1 -0.9 -0.7 -0.8 0.4 -0.5 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.7 -0.6 0.6 0.5 1.3 -0.1 1.0 1.0
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 1.7 -0.9 -0.8 -0.9 -1.3 0.8 -0.8 -1.2
Qualifications: CSEs or equivalent 0.9 1.2 2.2 1.5 -0.9 -1.4 -0.6 -1.2 -1.1 -0.9
Serious illness, injury or assault to yourself 0.5 0.6 1.1 1.1 -0.7 -1.0 -0.8 -0.1 -0.7 -0.8
High blood pressure 0.9 2.5 6.1 -1.7 2.5 1.9 1.1 1.4 1.2 0.9
Hayfever, allergic rhinitis or eczema 1.4 3.1 4.5 -0.7 2.1 1.7 2.1 0.9 2.1 2.1
Multivitamins +/- minerals 0.6 0.8 1.5 0.7 -1.2 -1.2 -1.1 -0.1 -0.8 -0.6
Stomach or abdominal pain in last month 0.5 0.7 3.3 -0.9 0.5 0.3 0.0 1.8 0.4 -0.2
Supplements: Glucosamine 0.1 0.1 0.6 -0.8 0.0 0.0 0.1 0.2 0.2 0.1
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 1.0 -1.0 0.5 -0.0 -0.1 0.7 0.1 -0.3
Medication: Atenolol 0.0 0.0 0.1 -0.1 -0.3 -0.2 0.0 -0.1 -0.1 -0.2
Medication: Levothyroxine sodium 0.6 0.9 1.5 -1.0 1.1 1.2 0.8 1.2 0.8 0.6
Sitting height 0.9 6.6 8.7 -2.7 3.0 2.6 2.2 2.9 2.7 1.9
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 -0.2 0.0 -0.2 -0.1 0.2 0.0 0.4
High blood pressure (mother) 0.3 0.4 1.0 -0.0 -0.0 -0.8 -0.7 0.7 -0.4 -1.0
Body mass index (BMI) 1.8 7.8 15.0 1.9 -3.1 -3.9 -2.8 -0.8 -2.8 -3.1
Impedance of leg (left) 1.2 6.0 7.5 -2.7 2.1 2.1 2.2 2.6 2.6 2.7
Leg predicted mass (left) 0.3 1.7 3.3 1.5 -0.6 -1.3 -1.1 -1.2 -1.3 -1.8
Trunk fat mass 0.6 2.4 6.4 0.5 -1.6 -2.5 -1.7 0.6 -1.4 -1.7
Waist circumference 0.4 1.6 3.7 0.3 -1.3 -1.9 -1.2 1.1 -0.9 -1.4
Number of incorrect matches in round 5.4 9.0 14.2 -3.8 2.6 3.0 2.7 3.0 3.0 2.9
Past tobacco smoking 5.3 9.7 14.2 1.9 -3.6 -3.1 -3.8 -1.1 -3.5 -3.8
Alcohol usually taken with meals 0.6 1.0 1.9 -1.3 1.4 0.9 0.9 0.5 1.1 0.7
Nervous feelings 0.8 1.4 2.7 -1.0 1.6 1.3 1.0 0.9 1.2 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.7 -0.9 0.2 -0.3 -0.2 0.8 -0.1 -0.6
Hearing difficulty/problems with background noise 0.3 0.5 0.8 -0.5 0.5 0.7 0.9 -0.6 0.6 0.9
Hair/balding pattern: Pattern 2 0.2 0.3 0.8 -0.2 0.9 0.9 0.6 -0.3 0.4 -0.1
Had menopause 0.2 0.2 0.6 -0.8 0.6 0.5 -0.0 0.3 0.0 -0.3
Had other major operations 0.1 0.1 0.4 0.3 -0.1 -0.4 -0.3 0.6 -0.1 -0.5
Forced vital capacity (FVC) 0.8 3.1 6.0 -0.5 2.0 2.4 2.1 0.1 1.8 1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 -0.5 0.6 0.3 1.3 -0.1 1.1 1.1
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 3.5 0.8 -1.9 -1.7 -1.4 -0.9 -1.5 -1.6
Qualifications: None of the above 0.1 0.2 0.6 -0.1 0.4 0.8 0.5 0.3 0.5 0.5
Financial difficulties in last 2 years 1.7 2.3 4.1 1.3 -1.2 -2.0 -1.8 -0.3 -1.6 -1.7
Mouth/teeth dental problems 0.5 0.7 1.1 0.4 -1.0 -1.1 -1.0 -0.6 -0.8 -0.9
Heart attack 0.3 0.4 0.8 -0.5 0.5 0.9 0.6 0.7 0.7 0.5
Allergy 0.6 1.3 1.8 0.5 -1.3 -1.1 -1.3 -0.8 -1.3 -1.3
Pain all over the body in last month 0.0 0.0 0.1 0.3 0.2 -0.1 0.1 0.2 -0.1 -0.3
Diabetes (self-reported) 1.1 1.7 2.4 -1.0 1.4 1.1 1.6 1.2 1.5 1.4
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.2 -1.8 1.4 0.8 1.0 1.6 1.2 0.9
Medication: Ramipril 0.2 0.2 0.4 -0.6 -0.3 -0.2 -0.3 0.6 -0.4 -0.6
Medication: Simvastatin 0.3 0.5 1.3 -0.1 0.6 0.7 0.5 1.1 0.8 0.7
Fluid intelligence score 0.2 0.5 0.9 -0.1 -0.6 -0.9 -0.9 -0.4 -0.8 -0.9
Illnesses of siblings 0.5 0.7 3.7 0.7 -0.4 -0.5 -0.1 -1.9 -0.6 -0.1
Neuroticism score 0.1 0.3 0.9 -0.5 1.0 0.6 0.4 0.4 0.4 -0.1
Weight 0.5 2.7 6.0 1.2 -1.4 -2.4 -1.6 -0.1 -1.6 -2.1
Impedance of arm (right) 0.6 2.6 4.2 -1.9 1.1 1.4 1.1 2.0 1.8 1.8
Arm fat percentage (right) 1.9 7.5 15.8 1.4 -3.2 -4.0 -2.9 -0.0 -2.6 -3.0
Trunk fat-free mass 0.2 1.0 2.3 1.4 -0.2 -0.6 -0.7 -1.0 -0.9 -1.5
Hip circumference 0.7 3.0 6.4 0.8 -1.5 -2.5 -1.9 0.7 -1.6 -2.2
Time employed in main current job 0.1 0.1 0.5 0.1 -0.4 -0.1 -0.4 0.7 -0.1 0.2
Alcohol intake versus 10 years previously 0.1 0.2 0.4 -0.1 0.6 0.6 0.3 0.4 0.3 0.4
Father’s age at death 0.9 1.2 2.6 -0.2 1.2 1.1 1.6 -0.8 1.1 1.1
Worrier / anxious feelings 0.2 0.3 1.2 0.0 0.8 1.1 -0.2 -0.2 -0.3 -0.4
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.7 6.4 0.4 -2.1 -2.3 -2.3 1.3 -1.8 -2.5
Falls in the last year 1.6 2.1 5.1 0.8 -1.4 -2.3 -1.5 -0.6 -1.4 -1.5
Hair/balding pattern: Pattern 3 0.7 1.1 2.2 -0.1 -1.4 -1.5 -0.9 -0.8 -1.2 -0.8
Number of live births 0.7 1.0 2.1 0.6 -0.6 -1.4 -1.2 -0.4 -1.0 -1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.9 0.2 0.7 0.7 0.5 -0.9 0.2 0.3
Pulse rate 0.9 1.5 2.3 -1.3 1.4 1.5 0.7 1.5 1.0 0.7
Happiness 0.4 0.5 1.2 0.1 -0.3 -1.1 -0.9 -0.2 -0.7 -1.1
Noisy workplace 0.1 0.1 0.5 -0.4 -0.7 -0.5 -0.1 0.1 -0.2 0.1
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.3 0.5 -0.2 -0.1 -0.1 -0.3 -0.1 -0.2
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 2.5 1.4 -0.9 -1.6 -1.0 -1.3 -1.3 -1.2
Mouth/teeth dental problems: Dentures 0.0 0.1 0.2 0.1 -0.4 -0.0 0.1 0.4 0.3 0.3
Asthma 0.0 0.1 0.3 -0.2 0.4 0.6 0.1 -0.3 -0.1 0.0
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.1 -0.2 -0.1 -0.1 0.2 -0.3 0.0 -0.3
Medication: Cholesterol lowering 0.5 0.7 1.3 -0.4 1.0 1.1 0.9 0.5 0.9 0.8
Depression (self-reported) 1.5 1.8 2.9 -1.1 1.5 0.7 1.7 1.1 1.6 1.5
Medication: Lansoprazole 1.3 1.4 5.1 -0.7 0.6 0.8 0.9 2.3 1.3 0.9
Prospective memory result 0.1 0.1 0.3 0.4 -0.5 -0.0 0.0 -0.3 -0.2 -0.2
Lung cancer (father) 1.4 1.6 2.1 1.4 -1.2 -1.3 -1.1 -1.2 -1.2 -1.4
Illnesses of mother 1.2 1.4 2.6 0.5 -1.5 -1.1 -1.2 -1.6 -1.3 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.4 0.1 0.6 0.6 0.6 -0.6 0.4 0.3
Pulse wave Arterial Stiffness index 1.2 1.4 1.8 -1.2 1.2 1.2 1.4 1.0 1.2 1.1
Impedance of arm (left) 1.0 4.5 6.2 -2.4 1.6 2.0 1.7 2.5 2.3 2.3
Arm fat mass (right) 1.6 6.7 13.4 1.7 -2.8 -3.7 -2.7 -0.5 -2.5 -3.0
Trunk predicted mass 0.2 1.1 2.6 1.4 -0.2 -0.8 -0.8 -1.0 -1.0 -1.6
Standing height 0.6 5.7 11.2 -1.3 3.3 2.8 2.6 1.4 2.6 2.1
Length of working week for main job 1.5 1.7 2.5 1.0 -1.6 -1.6 -1.5 -0.6 -1.3 -1.3
Exposure to tobacco smoke at home 0.1 0.1 0.3 -0.3 0.5 0.0 0.3 0.3 0.2 0.2
Breastfed as a baby 0.8 1.0 2.2 1.5 -1.2 -0.8 -0.5 -1.0 -0.8 -0.7
Tense / ‘highly strung’ 2.2 3.6 4.7 -1.8 2.1 2.1 2.2 0.6 2.0 1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.6 0.5 0.2 0.2 0.7 -0.7 0.2 0.0
Hair/balding pattern: Pattern 4 0.4 0.8 2.1 0.1 1.1 1.4 1.0 0.1 1.0 0.8
Birth weight of first child 2.8 5.2 7.3 2.5 -1.9 -2.7 -2.1 -2.3 -2.4 -2.1
Peak expiratory flow (PEF) 1.0 2.4 3.7 -1.4 1.7 1.4 1.8 0.3 1.7 1.9
Pulse wave reflection index 0.1 0.2 0.5 -0.4 -0.4 -0.1 0.4 0.7 0.4 0.4
Ever highly irritable/argumentative for 2 days 2.6 3.1 4.8 0.9 -2.0 -2.1 -2.2 0.3 -1.8 -2.1
Loud music exposure frequency 0.4 0.5 2.3 0.6 0.0 -0.5 -0.1 -1.5 -0.5 -0.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.6 -0.1 0.1 0.1 0.1 -0.8 0.0 0.1
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 3.3 -1.1 1.8 1.6 1.7 0.3 1.3 1.4
Blood clot in the leg (DVT) 0.1 0.1 0.3 -0.3 -0.5 0.3 0.2 0.5 0.2 -0.1
Medication: Paracetamol 0.3 0.5 0.9 0.6 -0.7 -0.9 -0.8 -0.5 -0.7 -0.4
Headache pain in last month 0.2 0.3 1.7 -0.2 -0.1 0.2 -0.0 1.3 0.2 -0.3
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 1.8 1.2 -1.3 -1.3 -0.8 -1.3 -1.1 -1.0
Glaucoma (self-reported) 0.7 0.8 1.3 1.0 -0.4 -0.6 -1.1 -0.8 -1.1 -1.1
Gout (self-reported) 0.2 0.3 0.9 -0.7 -0.2 0.3 0.7 0.1 0.6 0.9
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 2.0 -1.4 1.3 1.1 1.3 1.1 1.2 1.0
Medication: Amlodipine 0.6 0.8 1.2 0.8 -0.5 -0.5 -1.0 -1.1 -1.1 -1.0
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.7 1.6 -0.6 -0.6 -0.6 -1.9 -1.1 -0.6
Birth weight 0.5 1.1 4.6 1.6 0.3 0.2 -0.1 -2.1 -0.7 -0.3
Chronic bronchitis/emphysema (mother) 0.6 0.7 3.9 -0.5 -0.3 -0.3 0.2 2.0 0.5 0.4
High blood pressure (siblings) 0.4 0.6 1.4 0.5 -0.3 -1.0 -0.7 1.2 -0.5 -1.0
Forced vital capacity (FVC), Best measure 0.8 3.0 4.4 -0.9 1.9 2.1 2.1 0.8 1.9 1.8
Body fat percentage 0.9 3.5 9.1 0.4 -2.2 -3.0 -2.0 0.7 -1.6 -1.9
Leg fat percentage (right) 1.1 4.1 11.3 0.6 -2.3 -3.4 -2.1 0.3 -1.8 -2.1
Arm fat-free mass (right) 0.2 0.9 2.0 1.3 -0.2 -0.8 -0.7 -0.6 -0.9 -1.4
Exposure to tobacco smoke outside home 0.8 1.1 1.5 0.9 -0.8 -1.2 -1.1 -0.7 -1.2 -1.2
Comparative body size at age 10 0.1 0.3 1.1 0.2 -0.4 -0.1 -0.3 1.1 -0.3 -0.5
Number of full brothers 1.7 2.2 3.8 0.6 -1.9 -1.7 -1.9 0.4 -1.5 -1.4
Worry too long after embarrassment 0.1 0.1 0.4 0.3 0.6 0.4 0.3 -0.1 0.3 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.1 0.2 0.7 0.9 1.1 -0.9 0.7 0.8
Wheeze or whistling in the chest in last year 0.0 0.1 0.3 0.1 -0.3 -0.5 -0.1 0.3 -0.0 0.0
Number of children fathered 0.7 0.8 1.6 1.1 -0.3 -1.3 -0.8 -0.9 -0.9 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 3.3 -0.6 1.1 1.6 1.8 0.6 1.6 1.7
Age at first live birth 0.3 0.5 0.8 0.7 -0.9 -0.1 -0.7 -0.8 -0.9 -0.6
Pulse wave peak to peak time 1.0 1.2 1.5 1.1 -1.1 -1.1 -1.2 -0.8 -1.1 -1.1
Health satisfaction 1.4 1.8 3.6 0.5 -1.2 -1.6 -1.6 0.5 -1.4 -1.9
Shortness of breath walking on level ground 2.2 2.6 4.9 1.3 -2.2 -1.9 -1.7 -1.0 -1.6 -1.3
Qualifications: College or University degree 0.1 0.4 1.0 -0.1 0.1 -0.2 -0.8 -0.3 -0.8 -1.0
Eye problems/disorders: None of the above 0.4 0.5 1.0 -1.0 0.6 0.5 0.5 0.6 0.7 0.9
Mouth/teeth dental problems: Loose teeth 1.9 2.3 3.1 1.4 -1.6 -1.6 -1.6 -0.9 -1.6 -1.8
Emphysema/chronic bronchitis 0.2 0.2 0.8 -0.3 -0.3 -0.5 -0.4 0.9 -0.1 0.0
Medication for pain relief, constipation, heartburn 1.0 1.7 2.5 -1.3 1.2 1.4 1.4 0.5 1.4 1.6
Neck or shoulder pain in last month 0.3 0.5 0.9 -1.0 0.8 0.5 0.7 0.5 0.6 0.6
Medication: Blood pressure 0.1 0.3 0.8 -0.4 0.9 0.9 0.2 -0.0 0.1 0.2
Angina (self-reported) 0.4 0.6 1.3 0.3 -0.7 -0.8 -0.7 -1.1 -0.9 -0.5
Migraine (self-reported) 0.3 0.4 1.5 1.1 -0.4 -0.1 -0.0 -1.2 -0.2 -0.1
Medication: Ibuprofen 0.2 0.2 0.6 0.3 -0.2 -0.5 -0.1 -0.7 -0.3 -0.6
Medication: Allopurinol 0.4 0.5 1.0 0.2 -1.0 -1.0 -0.5 -0.6 -0.7 -0.4
Medication: Omeprazole 0.3 0.3 1.2 0.4 -0.3 -0.3 -0.5 1.1 -0.3 -0.7
Medication: Seretide 50 evohaler 2.4 2.7 5.4 1.5 -1.8 -1.7 -1.1 -2.3 -1.7 -1.0
Mean time to correctly identify matches 0.2 0.4 1.7 -0.1 -0.0 0.1 -0.5 1.3 -0.2 -0.7
Heart disease (mother) 0.1 0.2 0.5 0.7 -0.7 -0.1 0.0 -0.4 -0.2 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 1.8 -0.3 0.5 1.3 1.0 0.5 1.1 1.4
Whole body fat mass 0.7 2.7 6.7 0.8 -1.7 -2.6 -1.7 0.2 -1.6 -1.9
Leg fat mass (right) 0.9 3.4 8.9 0.9 -1.9 -3.0 -1.8 -0.1 -1.7 -2.1
Arm predicted mass (right) 0.2 1.0 2.3 1.2 -0.4 -0.9 -0.7 -0.8 -1.0 -1.5
Pulse rate, automated reading 0.9 2.8 6.0 -1.5 1.5 1.2 1.4 2.5 1.7 1.6
Alcohol intake frequency. 0.2 0.4 0.8 0.6 -0.5 -0.5 -0.8 0.9 -0.5 -0.4
Comparative height size at age 10 1.1 6.0 7.4 -2.1 2.7 2.5 2.4 2.3 2.6 2.3
Number of full sisters 0.5 0.6 2.5 -1.3 -0.4 0.0 0.1 1.6 0.4 0.2
Suffer from ‘nerves’ 0.5 0.8 1.3 -0.7 1.1 0.9 1.1 0.4 1.0 0.9
Overall health rating 0.4 0.8 3.5 -1.3 0.3 0.0 0.2 1.9 0.4 -0.0
Chest pain or discomfort 5.6 8.1 11.3 1.7 -3.1 -3.4 -3.1 -1.5 -3.1 -3.3
Had major operations 0.4 0.5 1.0 -0.8 1.0 0.5 0.6 -0.5 0.5 0.8
Age at last live birth 0.1 0.1 0.2 0.2 -0.3 0.1 -0.3 -0.4 -0.3 -0.3
Family relationship satisfaction 2.8 3.4 4.8 1.5 -1.9 -2.2 -2.0 -1.3 -2.0 -1.9
Leg pain on walking 0.3 0.4 0.7 0.1 -0.7 -0.8 -0.6 -0.0 -0.7 -0.9
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 2.9 -1.0 0.7 0.8 1.5 1.1 1.5 1.7
Commuting to job workplace: Car/motor vehicle 1.4 1.6 3.5 1.3 -1.3 -1.9 -1.0 -1.1 -1.2 -1.0
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.1 -1.2 0.8 1.4 0.6 0.8 0.8 0.6
Medication: Aspirin 0.2 0.2 0.6 -0.8 0.1 -0.0 0.3 0.8 0.4 0.3
Supplements: Vitamin C 0.2 0.2 0.8 -0.3 -0.0 0.2 -0.5 0.9 -0.2 -0.4
Knee pain experienced in last month 0.3 0.4 0.9 -0.2 0.6 0.1 0.7 0.7 0.8 0.9
Hypertension (Self-reported) 0.7 2.1 5.5 -1.6 2.3 1.6 0.9 1.3 1.0 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 5.7 -0.8 0.3 0.3 -0.0 2.4 0.4 -0.2
Illnesses of father: Heart disease 0.3 0.4 0.9 0.4 -0.6 -0.8 -1.0 0.4 -0.7 -0.6
Illnesses of siblings: Diabetes 0.4 0.5 1.1 -0.1 0.9 0.4 1.1 0.3 0.9 0.9
Smoking status: Previous 6.0 9.0 13.5 -1.8 3.5 3.0 3.7 0.9 3.3 3.7
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.0 -0.2 1.0 0.4 0.8 -0.2 0.6 0.7
Whole body fat-free mass 0.2 1.2 2.6 1.4 -0.3 -0.9 -0.8 -1.0 -1.1 -1.6
Leg fat-free mass (right) 0.3 1.4 2.8 1.4 -0.5 -1.0 -1.0 -1.1 -1.3 -1.7
Arm fat percentage (left) 1.6 6.5 13.8 1.1 -3.0 -3.7 -2.8 0.3 -2.4 -2.8
Average weekly red wine intake 0.1 0.2 0.5 0.7 0.2 -0.5 -0.1 -0.6 -0.1 -0.2
Handedness (chirality/laterality): Left-handed 1.5 1.7 2.6 1.3 -1.6 -1.6 -1.2 -0.7 -1.3 -1.4
Mood swings 0.2 0.3 0.9 -0.7 0.8 0.2 0.1 0.9 0.3 -0.1
Loneliness, isolation 0.4 0.5 2.8 -0.2 -0.1 0.1 -0.4 1.7 -0.1 -0.8
Long-standing illness, disability or infirmity 0.3 0.5 1.1 -0.8 1.1 0.3 0.6 0.8 0.7 0.5
Ever had bowel cancer screening 0.7 0.8 1.7 0.5 -1.3 -1.2 -0.9 -0.4 -0.8 -0.6
Diabetes diagnosed by doctor 0.9 1.6 2.8 -1.3 1.2 0.6 1.2 1.7 1.3 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.4 0.3 -0.3 -0.5 -0.7 1.2 -0.3 -0.6
Friendships satisfaction 0.3 0.3 1.0 0.2 -0.7 -1.0 -0.3 0.5 -0.2 -0.7
Qualifications: nursing, teaching 1.2 1.9 4.8 0.8 -1.6 -2.2 -1.2 -0.9 -1.2 -1.2
Commuting to job workplace: Walk 3.2 3.4 7.6 -1.1 2.2 2.8 1.7 1.1 1.9 1.6
Eye problems/disorders: Cataract 1.5 1.7 2.8 1.0 -1.0 -1.4 -1.5 -0.8 -1.5 -1.7
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 2.2 -1.1 1.5 1.3 1.1 0.5 1.0 0.7
Medication for cholesterol 0.3 0.5 2.2 -0.4 0.5 0.5 0.5 -1.5 0.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 0.3 0.4 -0.0 -0.1 0.3 0.1 -0.2
Back pain experienced in last month 0.1 0.1 0.3 0.5 0.0 0.3 0.3 0.2 0.2 0.1
Mineral and other dietary supplements 0.1 0.1 0.2 0.4 0.3 -0.2 -0.2 -0.3 -0.3 -0.5
Breast cancer (self-reported) 0.4 0.4 1.3 1.2 0.5 0.2 0.3 -1.1 -0.2 0.2
Asthma (self-reported) 0.0 0.0 0.1 -0.2 0.2 0.3 -0.1 -0.2 -0.2 -0.1
Osteoporosis (self-reported) 2.5 3.1 5.0 -0.9 1.8 1.9 2.0 1.1 2.1 2.2
Osteoarthritis (self-reported) 0.1 0.1 0.4 0.1 0.6 0.5 0.4 -0.0 0.2 0.0
Medication: Aspirin 0.2 0.2 0.6 -0.7 0.4 0.1 0.2 0.7 0.4 0.2
Medication: Gliclazide 0.6 0.7 1.8 -1.2 0.6 -0.5 0.5 1.3 0.7 0.6
Illnesses of father: None of the above (group 1) 1.0 1.3 2.5 1.5 -1.2 -0.5 -0.9 -1.6 -0.9 -0.9
Smoking status: Current 0.1 0.2 0.4 0.1 0.2 0.2 0.2 0.5 0.5 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.0 0.2 0.1 0.0 0.1 -0.0 -0.5 -0.1 0.1
Whole body water mass 0.2 1.3 2.8 1.5 -0.3 -0.9 -0.8 -1.1 -1.1 -1.7
Leg predicted mass (right) 0.2 1.3 2.7 1.4 -0.4 -1.0 -0.9 -1.1 -1.2 -1.6
Arm fat mass (left) 1.3 5.3 10.8 1.4 -2.5 -3.3 -2.4 -0.0 -2.2 -2.7
Number of self-reported non-cancer illnesses 0.7 1.2 2.4 -0.8 1.3 1.1 0.8 1.6 1.0 0.7
Average weekly champagne plus white wine intake 1.1 1.5 2.6 -1.6 1.1 1.1 0.8 1.6 1.1 0.9
Miserableness 0.2 0.3 0.9 0.4 -0.5 -0.4 -0.7 0.4 -0.6 -0.9
Guilty feelings 0.2 0.4 0.9 -0.0 1.0 0.8 0.7 -0.0 0.5 0.5
Wears glasses or contact lenses 0.3 0.4 1.0 0.1 1.0 0.9 0.7 -0.3 0.4 0.5
Ever taken oral contraceptive pill 0.3 0.3 0.6 0.7 0.8 0.4 0.7 -0.2 0.5 0.5
Hearing aid user 0.5 0.5 0.8 -0.7 0.9 0.6 0.9 -0.0 0.9 0.8
Mother’s age at death 2.3 2.9 4.8 -1.2 1.4 2.2 2.1 0.7 1.9 1.8
Financial situation satisfaction 2.8 3.5 6.2 0.9 -1.7 -2.3 -2.1 -0.9 -2.0 -2.5
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.6 0.4 0.0 -0.1 0.1 -1.2 -0.2 0.6
Commuting to job workplace: Public transport 0.2 0.3 0.7 -0.0 0.5 0.8 -0.4 0.5 -0.3 -0.5
Eye problems/disorders: Glaucoma 1.0 1.2 2.4 1.5 -0.5 -0.5 -1.0 -1.5 -1.1 -1.1
Medication: Blood pressure 0.3 0.5 1.9 -1.0 0.5 0.3 0.3 1.4 0.4 0.1
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.4 0.1 0.2 -0.0 0.5 -0.6 0.2 0.3
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.3 0.2 -0.6 -0.0 -0.3 0.1 -0.0 0.1
High cholesterol (Self-reported) 0.6 1.1 2.8 0.8 1.2 1.7 0.9 0.3 1.0 1.1
Medication: Bendroflumethiazide 0.5 0.7 1.3 -0.9 1.1 1.0 0.6 0.4 0.7 1.1
Medication: Paracetamol 0.1 0.1 0.2 0.4 -0.2 -0.4 -0.1 -0.4 -0.1 0.2
Medication: Lisinopril 1.5 2.0 4.5 -0.6 2.1 1.5 1.1 1.5 1.4 1.2
Medication: Atorvastatin 0.2 0.3 0.7 0.1 0.9 0.5 0.6 0.3 0.5 0.7
Illnesses of father: High blood pressure 0.9 1.1 1.6 -1.2 1.2 1.1 1.1 0.8 0.9 0.8
Alcohol drinker status: Never 0.1 0.2 0.7 0.2 -0.3 -0.9 -0.3 0.3 -0.1 -0.1
Ever smoked 4.1 7.1 10.6 -1.5 3.3 2.6 3.2 1.1 3.0 3.2
Basal metabolic rate 0.3 1.9 3.8 1.6 -0.8 -1.4 -1.2 -1.0 -1.4 -2.0
Leg fat percentage (left) 1.1 3.9 10.4 0.4 -2.2 -3.2 -2.1 0.2 -1.9 -2.0
Arm fat-free mass (left) 0.3 1.7 3.9 1.3 -0.7 -1.4 -1.2 -0.8 -1.4 -2.0
Number of operations (self-reported) 0.4 0.6 2.0 1.0 0.0 -0.9 -0.4 -1.4 -0.6 -0.3
Average weekly beer plus cider intake 1.0 1.4 5.0 1.3 -1.3 -0.3 -0.5 -2.2 -1.0 -0.3
Irritability 1.3 2.2 3.9 -1.7 1.3 1.6 1.1 2.0 1.4 1.1
Risk taking 0.6 0.8 1.6 1.1 -1.3 -0.8 -0.9 -0.1 -0.8 -0.9
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.7 1.3 -1.1 -1.2 -0.7 -0.5 -0.6 -0.4
Fractured/broken bones in last 5 years 0.2 0.3 0.8 0.7 0.1 -0.2 -0.4 -0.7 -0.5 -0.9
Age started oral contraceptive pill 0.6 0.7 1.6 1.2 -0.7 -0.1 -0.6 -1.3 -0.8 -0.8
Diastolic blood pressure, automated reading 1.2 3.6 6.2 1.7 -1.5 -2.5 -2.2 0.2 -2.0 -2.2
Ever depressed for a whole week 1.1 1.4 2.8 -0.1 -1.6 -1.7 -1.3 -0.3 -1.1 -1.2
Unable to work because of sickness or disability 0.3 0.4 1.1 0.6 -0.8 -1.0 -0.6 -0.2 -0.5 -0.5
Commuting to job workplace: Cycle 0.1 0.1 0.4 -0.6 0.2 -0.0 -0.2 0.0 -0.1 -0.4
Myopia 0.6 0.9 3.3 1.1 -0.4 -0.6 -0.3 -1.8 -0.8 -0.3
Vascular/heart problems diagnosed by doctor 1.5 4.0 9.3 1.8 -3.0 -2.4 -1.7 -1.4 -1.7 -1.4
Cholesterol lowering medication 0.1 0.2 1.0 1.0 -0.1 0.1 0.1 0.3 0.1 0.2
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 2.7 0.0 0.7 0.8 0.6 1.6 0.8 0.5
Pain experienced in last month 0.2 0.3 0.8 0.0 -0.6 -0.4 -0.9 -0.3 -0.7 -0.7
Supplements: Calcium 0.9 1.0 2.1 -1.5 0.2 0.3 1.0 1.1 1.1 1.1
Basal cell carcinoma (self-reported) 1.5 1.8 2.3 1.3 -1.4 -1.4 -1.4 -1.2 -1.5 -1.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 -0.5 0.6 0.9 0.7 0.6 0.7 0.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.4 -0.3 -0.4 0.4 0.3 0.6 0.2 -0.1
Heart disease (siblings) 0.2 0.3 0.6 0.4 -0.7 -0.2 -0.8 -0.1 -0.5 -0.6
Alcohol drinker status: Previous 0.9 1.1 1.6 0.6 -1.3 -1.3 -1.2 -0.1 -1.1 -1.0
Pack years of smoking 1.0 1.5 2.7 -0.5 1.4 1.4 1.6 0.3 1.4 1.4
Impedance of whole body 1.2 6.2 8.4 -2.9 2.0 2.1 2.0 2.9 2.6 2.7
Leg fat mass (left) 0.8 3.0 7.6 0.7 -1.8 -2.8 -1.7 0.0 -1.7 -2.0
Arm predicted mass (left) 0.4 2.0 4.1 1.6 -0.8 -1.4 -1.2 -1.1 -1.5 -2.0