Hub : Genes

ZNF442

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.149 0.064 0.0043 0.011 NA 0.011 NA 0.018 8.8e-02 NA 0.08400 NA 3.7e-02
2 GTEx Testis 0.161 0.065 0.0055 0.064 NA 0.020 NA 0.015 8.7e-04 NA 0.04500 NA 6.6e-02
3 TCGA Thyroid Carcinoma 0.088 0.043 0.0014 0.044 0.046 0.028 NA 0.039 3.7e-05 2.7e-05 0.00091 NA 9.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.3 0.6 -0.8 0.3 0.3
Bipolar Disorder or Schizophrenia 0.2 0.4 0.8 -0.5 -0.9 0.5
Depressed Affect (Nagel 2018) 0.7 1.5 2.8 -1.3 -0.0 -1.7
Depression (Nagel 2018) 0.5 0.8 1.3 -1.0 -0.4 -1.1
Intelligence (Savage-Jansen 2018) 2.0 6.2 14.5 -0.9 -1.8 -3.8
Neuroticism (Nagel 2018) 0.6 1.4 2.8 -1.1 -0.5 -1.7
Schizophrenia (2018) 0.3 0.6 1.9 -0.1 -1.4 0.3
Schizophrenia vs Biploar Disorder 0.3 0.4 0.6 -0.7 0.3 0.8
Worry (Nagel 2018) 0.2 0.4 0.5 0.4 -0.7 -0.7
Alzheimer’s Disease (in mother) 0.4 0.5 1.4 0.0 1.2 -0.2
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.1 0.1 -0.4
Alzheimer’s Disease (including proxy) 0.4 0.5 1.5 -0.2 1.2 0.2
Crohns Disease (2017) 0.2 0.4 0.8 0.9 0.4 0.5
Irritable Bowel Disease (IBD) 0.4 1.0 1.6 -0.9 0.9 1.3
Ulcerative Colitis (UC) 1.3 2.4 3.2 -1.8 1.4 1.5
Major Depression (MDD) 0.1 0.2 0.3 -0.5 0.1 -0.6
Reaction Time 0.7 1.4 2.5 0.3 1.2 1.6
Verbal and Numeric Reasoning (VNR) 3.1 7.3 15.1 0.7 -2.5 -3.9
Breast Cancer 0.9 2.3 4.5 0.6 1.4 2.1
Ovarian Cancer 0.7 0.9 1.0 0.9 -1.0 -0.9
Prostate Cancer 0.1 0.1 0.1 -0.2 -0.3 -0.3
Age at First Birth 0.5 0.8 2.1 1.5 0.3 -0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 1.2 -0.3 -1.1 -0.5
Coronary Artery Disease (CAD) 0.7 0.9 2.5 -1.6 0.3 0.1
Crohns Disease (2012) 0.3 0.5 0.9 -0.7 0.4 0.9
Mean Putamen Volume 0.8 0.9 1.8 0.3 0.9 1.3
Fasting Glucose 0.5 0.6 1.4 -0.2 0.7 -1.2
HbA1C 0.4 0.4 0.5 0.6 0.6 -0.7
HDL Cholesterol 0.3 0.5 0.9 0.1 0.9 0.8
LDL Cholesterol 0.2 0.2 0.7 0.8 -0.2 0.0
Lupus 1.6 2.4 6.1 0.5 -0.9 -2.5
Neuroticism (2016) 0.6 0.9 1.6 0.8 0.7 -1.3
Primary Biliary Cirrhosis 0.6 0.8 2.5 -0.2 1.6 -0.1
Rheumatoid Arthritis 0.1 0.2 0.3 0.5 0.1 -0.6
Schizophrenia (2014) 0.5 1.1 2.2 -1.0 -1.5 0.4
Triglycerides 0.6 1.0 2.0 -1.4 -0.5 0.9
Type 2 Diabetes (T2D) (2012) 2.0 2.3 4.7 -1.2 2.2 -0.9
Ulcerative Colitis 1.7 2.4 4.2 -2.0 0.1 1.8
Blood Eosinophil Count 0.2 1.5 4.4 -0.1 -2.1 0.5
Blood Platelet Count 0.4 4.8 12.0 -0.7 1.4 -3.5
Blood Red Count 0.8 8.0 9.7 2.2 -3.0 3.1
Blood White Count 0.1 0.4 1.1 -0.0 -1.1 -0.1
Heel T-Score 0.7 5.8 15.2 0.2 -1.5 3.9
BMI 0.3 1.6 2.9 -1.7 -0.9 -1.1
Height 1.9 35.7 68.6 -5.8 8.3 -2.3
Waist Hip Ratio (WHR) 0.7 2.9 4.9 -0.7 2.2 -1.8
Systolic Blood Pressure 0.5 2.6 6.2 -1.1 0.6 -2.5
Smoking Status 0.4 1.0 1.9 0.7 0.8 -1.4
Allergy or Eczema 0.5 1.4 3.1 0.9 -0.6 -1.8
Cardiovascular Disease 1.2 4.1 8.9 -1.7 0.6 -3.0
Hypothyroidism (self reported) 0.7 1.5 4.0 -0.3 -0.7 -2.0
Respiratory disease 1.6 3.5 9.1 -1.1 0.3 3.0
Type 2 Diabetes (T2D) (2018) 2.8 5.2 11.6 -2.0 3.4 -0.4
Lung FEV1/FVC ratio 0.7 3.7 4.2 2.0 -1.7 -2.1
Lung FVC 1.5 7.6 10.9 3.1 -3.3 -1.5
Neuroticism 0.3 0.7 2.0 -0.0 0.4 -1.4
Chronotype (morning person) 0.2 0.6 1.1 0.1 -0.7 -1.1
Hair Pigment 0.0 1.3 2.0 -1.4 -0.9 -1.0
Tanning 0.0 0.4 0.7 0.7 0.9 -0.2
Hand grip strength (left) 1.2 3.1 3.9 -2.0 1.9 1.3
Number of treatments/medications taken 0.8 1.5 4.4 -0.4 -0.1 -2.1
Average weekly spirits intake 1.0 1.2 2.7 -1.6 -1.0 0.3
Sensitivity / hurt feelings 0.2 0.4 0.8 -0.5 0.9 -0.4
Frequency of depressed mood in last 2 weeks 1.0 1.4 2.7 -0.5 -1.1 1.6
Hearing difficulty/problems: Yes 1.8 2.7 7.6 0.1 -2.8 0.7
Relative age of first facial hair 0.4 0.9 1.6 -0.9 0.6 -1.2
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 0.0 0.5 -0.4
Ever used hormone-replacement therapy (HRT) 0.0 0.1 0.1 0.3 0.3 0.1
Ever had hysterectomy (womb removed) 2.0 2.3 3.2 -1.7 1.8 1.0
Systolic blood pressure, automated reading 0.8 2.2 6.3 0.4 -0.4 -2.5
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 4.0 -2.0 1.2 0.5
Angina 0.4 0.6 1.2 1.1 0.3 0.6
Medication for hormone replacement therapy 0.7 0.8 1.7 -0.3 -1.3 0.8
Vitamin and mineral supplements 0.1 0.2 0.4 0.1 0.6 0.4
Supplements: Zinc 0.1 0.1 0.2 -0.1 -0.4 0.4
Medication: Co-codamol 2.0 2.4 3.3 1.8 -1.0 -1.7
Medication: Metformin 1.2 1.7 3.5 -1.9 1.1 0.6
Diabetes (father) 1.1 1.4 2.0 -1.4 1.1 0.9
Diabetes (mother) 2.1 2.7 6.0 -0.2 2.5 1.4
Severe depression (siblings) 0.5 0.5 0.8 -0.3 -0.8 -0.9
Pack years adult smoking proportion 0.8 1.2 3.5 -0.3 1.9 0.1
Impedance of leg (right) 0.4 1.9 5.2 0.4 2.3 -0.6
Leg fat-free mass (left) 1.1 5.9 14.1 -3.8 1.9 -0.2
Trunk fat percentage 0.2 0.7 1.3 -1.2 -0.1 -0.9
Hand grip strength (right) 0.5 1.5 1.7 -1.3 1.1 1.2
Townsend deprivation index at recruitment 1.1 1.5 3.9 0.3 0.7 2.0
Current tobacco smoking 0.7 1.2 1.9 1.3 0.2 -1.4
Average weekly fortified wine intake 0.8 0.9 1.8 1.3 0.7 -0.7
Maternal smoking around birth 1.1 1.6 2.7 0.2 1.6 -1.4
Fed-up feelings 0.9 1.7 3.6 0.0 1.2 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.3 -0.5 0.0 -0.3
Relative age voice broke 0.8 1.2 1.8 -0.9 1.4 -0.9
Taking other prescription medications 1.0 1.5 2.1 1.4 -0.6 -1.4
Age when periods started (menarche) 1.1 2.6 6.2 -0.7 2.5 -0.9
Bilateral oophorectomy (both ovaries removed) 2.2 2.6 4.4 -1.7 2.1 0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.4 3.4 -1.9 -1.0 1.7
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.5 -0.4 0.1
Qualifications: CSEs or equivalent 1.4 1.9 3.4 -1.9 -1.1 -1.0
Serious illness, injury or assault to yourself 1.4 1.6 3.5 -1.9 -1.1 0.6
High blood pressure 1.4 3.9 11.1 -0.4 -0.6 -3.3
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.8 -0.4 -1.3 -0.8
Multivitamins +/- minerals 0.7 0.9 2.2 -0.7 -1.5 -0.4
Stomach or abdominal pain in last month 2.5 3.1 4.4 -1.0 -2.0 2.1
Supplements: Glucosamine 0.8 1.1 2.7 -0.5 -1.7 -0.3
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.4 -1.2 -1.0 0.4
Medication: Atenolol 0.9 1.2 2.7 0.7 -0.6 -1.6
Medication: Levothyroxine sodium 1.7 2.9 7.8 0.9 -0.1 -2.8
Sitting height 1.9 13.3 26.5 -3.6 5.1 0.6
Chronic bronchitis/emphysema (father) 0.6 0.7 1.6 -1.2 -0.4 0.5
High blood pressure (mother) 0.9 1.2 2.1 -1.2 0.3 -1.5
Body mass index (BMI) 0.4 1.9 3.4 -1.5 -1.8 -0.2
Impedance of leg (left) 0.3 1.5 3.8 0.8 2.0 -0.3
Leg predicted mass (left) 1.1 6.0 14.1 -3.8 2.0 -0.2
Trunk fat mass 0.5 2.2 5.0 -2.2 0.7 -1.0
Waist circumference 0.5 2.0 3.3 -1.8 -0.0 -1.6
Number of incorrect matches in round 6.7 11.2 20.5 0.5 3.6 4.5
Past tobacco smoking 0.3 0.5 1.0 0.0 -1.0 0.6
Alcohol usually taken with meals 0.2 0.4 1.2 -1.1 -0.1 0.1
Nervous feelings 0.2 0.3 0.5 0.7 -0.0 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.9 0.4 -0.7 1.0
Hearing difficulty/problems with background noise 1.3 2.2 5.6 0.0 -0.9 2.4
Hair/balding pattern: Pattern 2 1.9 2.4 6.1 2.5 1.0 0.3
Had menopause 0.4 0.5 1.1 1.0 -0.3 -0.7
Had other major operations 0.4 0.5 0.7 -0.8 0.3 0.9
Forced vital capacity (FVC) 0.2 0.7 1.2 -0.9 0.3 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 4.2 -1.1 -1.1 2.0
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.0 0.3 1.0 0.0
Qualifications: None of the above 0.7 1.5 2.4 1.0 1.0 1.6
Financial difficulties in last 2 years 1.4 1.9 4.7 0.9 -2.2 -0.2
Mouth/teeth dental problems 0.5 0.8 2.4 0.3 -0.0 -1.6
Heart attack 0.7 1.0 2.6 -1.6 -0.4 -0.3
Allergy 0.4 0.8 2.0 1.4 0.7 -0.1
Pain all over the body in last month 2.2 2.3 4.5 -2.1 -0.6 1.5
Diabetes (self-reported) 2.6 4.0 7.7 -2.0 2.8 -0.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 -0.7 0.9 -0.3
Medication: Ramipril 0.3 0.4 0.7 -0.6 -0.0 -0.8
Medication: Simvastatin 0.3 0.5 1.0 0.1 -0.6 -1.0
Fluid intelligence score 1.6 3.3 7.1 -0.1 -1.7 -2.7
Illnesses of siblings 0.5 0.7 1.3 0.1 1.1 0.8
Neuroticism score 0.0 0.1 0.2 -0.1 0.5 -0.2
Weight 1.0 4.8 11.4 -3.4 1.6 -0.7
Impedance of arm (right) 0.3 1.2 1.6 1.3 0.8 -1.2
Arm fat percentage (right) 0.4 1.5 2.7 -1.1 -1.6 -0.9
Trunk fat-free mass 1.9 11.0 21.0 -4.6 3.5 -0.1
Hip circumference 0.8 3.3 7.7 -2.8 0.3 -1.4
Time employed in main current job 0.0 0.0 0.0 -0.0 0.2 0.1
Alcohol intake versus 10 years previously 0.4 0.7 1.3 -0.6 0.5 -1.2
Father’s age at death 0.1 0.2 0.3 -0.2 0.3 0.6
Worrier / anxious feelings 0.2 0.4 1.3 1.1 0.0 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.0 -0.1 -1.0 -0.0
Falls in the last year 0.3 0.4 0.7 0.8 -0.7 0.2
Hair/balding pattern: Pattern 3 0.4 0.5 1.3 -0.2 0.5 1.1
Number of live births 0.1 0.1 0.1 -0.4 -0.4 -0.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.8 -0.2 -0.5 -1.3
Pulse rate 0.7 1.2 3.5 0.0 0.0 -1.9
Happiness 1.1 1.3 2.2 -1.5 -0.4 -1.3
Noisy workplace 0.9 1.1 1.9 0.3 -1.2 1.4
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.1 0.0 -0.1 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.0 -1.0 -1.0 -0.4
Mouth/teeth dental problems: Dentures 0.4 0.7 1.7 0.5 1.3 0.1
Asthma 0.4 0.8 1.8 -0.6 0.3 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.7 -0.3 -1.3 0.3
Medication: Cholesterol lowering 0.6 0.9 1.4 0.7 1.2 -0.8
Depression (self-reported) 0.1 0.1 0.2 0.2 0.0 0.4
Medication: Lansoprazole 0.1 0.1 0.3 -0.3 0.1 0.5
Prospective memory result 0.4 0.5 1.4 0.0 1.2 0.4
Lung cancer (father) 0.9 1.1 2.2 0.6 0.9 1.5
Illnesses of mother 0.5 0.6 1.8 -0.3 -0.1 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 1.9 -0.3 -0.7 -1.4
Pulse wave Arterial Stiffness index 0.7 0.8 2.4 -1.5 0.3 0.2
Impedance of arm (left) 0.4 1.9 3.9 2.0 1.2 -0.7
Arm fat mass (right) 0.4 1.8 4.5 -2.1 -0.7 -0.5
Trunk predicted mass 1.8 10.5 20.8 -4.6 3.3 -0.2
Standing height 2.9 28.5 61.3 -4.9 7.8 -0.7
Length of working week for main job 0.1 0.1 0.2 -0.3 -0.4 -0.0
Exposure to tobacco smoke at home 0.4 0.4 1.1 1.1 -0.3 -0.2
Breastfed as a baby 0.5 0.6 0.9 -1.0 -0.3 0.9
Tense / ‘highly strung’ 0.2 0.3 0.8 0.9 -0.3 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.5 0.7 0.0 0.4
Hair/balding pattern: Pattern 4 0.3 0.6 1.5 -0.3 -0.5 -1.2
Birth weight of first child 0.8 1.4 2.7 -0.8 0.9 -1.6
Peak expiratory flow (PEF) 0.3 0.8 1.5 -0.6 -1.2 -0.8
Pulse wave reflection index 0.6 0.7 1.4 -1.2 -0.6 0.6
Ever highly irritable/argumentative for 2 days 3.4 4.1 7.1 -2.7 0.6 2.2
Loud music exposure frequency 1.7 1.9 3.7 -1.1 -0.9 1.9
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 3.8 -0.8 -1.9 -1.8
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 4.0 -0.3 0.7 2.0
Blood clot in the leg (DVT) 0.5 0.7 1.1 -0.5 0.8 1.1
Medication: Paracetamol 1.3 2.2 3.6 1.9 -1.5 -0.9
Headache pain in last month 0.6 1.0 2.9 -0.0 -1.7 -0.5
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 2.6 0.3 -1.0 1.6
Glaucoma (self-reported) 1.9 2.2 3.0 1.3 -1.4 -1.7
Gout (self-reported) 0.1 0.1 0.4 0.1 -0.6 -0.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.5 0.3 -0.1 -1.6
Medication: Amlodipine 1.0 1.3 4.0 0.0 2.0 0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.8 -0.3 0.3 0.9
Birth weight 0.4 0.8 1.2 1.1 0.7 -0.9
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.5 -0.7 -1.2 0.2
High blood pressure (siblings) 0.9 1.3 2.3 -0.7 -1.1 -1.5
Forced vital capacity (FVC), Best measure 0.4 1.4 3.2 -1.0 0.2 -1.8
Body fat percentage 0.2 0.9 1.3 -1.1 -0.6 -1.1
Leg fat percentage (right) 0.6 2.0 2.5 -1.4 -1.3 -1.6
Arm fat-free mass (right) 1.5 7.7 14.5 -3.8 2.9 0.2
Exposure to tobacco smoke outside home 1.0 1.4 3.4 1.8 -0.8 -0.4
Comparative body size at age 10 0.2 0.5 1.0 -0.1 -1.0 -0.6
Number of full brothers 0.3 0.4 1.3 0.2 -0.1 1.1
Worry too long after embarrassment 0.2 0.3 0.8 -0.2 -0.3 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.3 0.2 0.2 -0.6
Wheeze or whistling in the chest in last year 0.3 0.4 0.8 -0.5 -0.9 0.6
Number of children fathered 0.6 0.6 1.5 -1.2 0.6 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.0 0.0 -0.2 -0.2
Age at first live birth 2.0 3.6 6.6 2.6 1.3 -1.5
Pulse wave peak to peak time 0.5 0.6 1.6 1.3 0.2 -0.2
Health satisfaction 0.8 1.0 2.8 -0.5 -1.7 -0.0
Shortness of breath walking on level ground 0.5 0.6 0.9 -0.9 -0.7 -0.6
Qualifications: College or University degree 0.6 1.8 4.8 0.5 -0.6 -2.2
Eye problems/disorders: None of the above 1.7 2.0 5.4 -0.8 2.3 0.1
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.3 -0.5 0.2
Emphysema/chronic bronchitis 1.7 2.0 3.3 -1.8 0.5 1.5
Medication for pain relief, constipation, heartburn 0.9 1.5 2.6 -0.1 1.4 1.6
Neck or shoulder pain in last month 1.2 1.8 2.2 1.3 -1.1 1.5
Medication: Blood pressure 0.9 1.6 4.0 -0.3 0.8 -2.0
Angina (self-reported) 0.6 0.7 1.1 1.0 0.6 0.9
Migraine (self-reported) 0.4 0.5 0.7 -0.7 0.6 -0.9
Medication: Ibuprofen 0.1 0.1 0.3 0.0 -0.6 0.3
Medication: Allopurinol 0.1 0.2 0.4 -0.2 0.6 -0.2
Medication: Omeprazole 0.9 1.1 3.1 -1.8 0.2 -0.4
Medication: Seretide 50 evohaler 2.8 3.2 8.2 -0.3 1.1 2.9
Mean time to correctly identify matches 0.7 1.3 3.4 1.9 0.6 0.4
Heart disease (mother) 0.4 0.5 0.8 -0.3 -0.7 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.6 0.8 -0.3 -1.6
Whole body fat mass 0.5 2.1 5.1 -2.3 0.5 -1.0
Leg fat mass (right) 0.6 2.2 5.5 -2.3 -0.2 -1.1
Arm predicted mass (right) 1.5 7.7 15.5 -3.9 2.7 0.5
Pulse rate, automated reading 0.4 1.2 2.2 -0.4 -1.1 -1.5
Alcohol intake frequency. 0.3 0.6 1.6 -1.3 -0.2 -0.4
Comparative height size at age 10 1.2 6.4 12.6 -3.6 2.5 -0.0
Number of full sisters 0.9 1.1 2.3 0.5 0.9 -1.5
Suffer from ‘nerves’ 0.4 0.7 1.5 1.2 -0.5 0.5
Overall health rating 0.2 0.5 1.2 0.3 -0.4 -1.1
Chest pain or discomfort 0.6 0.9 2.5 -0.2 -1.6 -0.2
Had major operations 1.7 2.0 3.8 2.0 -1.3 -0.6
Age at last live birth 0.4 0.6 0.8 0.9 0.6 0.8
Family relationship satisfaction 1.8 2.2 5.0 -1.0 -2.2 0.8
Leg pain on walking 2.6 3.3 4.8 1.0 -2.0 -2.2
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.8 -1.3 -0.7 0.3
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.3 -0.3 1.0 -1.5
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.5 0.2 -0.4
Medication: Aspirin 1.4 1.9 4.9 -0.1 -0.8 -2.2
Supplements: Vitamin C 0.6 0.8 1.6 0.5 -0.7 -1.3
Knee pain experienced in last month 0.9 1.4 3.9 0.3 -2.0 0.2
Hypertension (Self-reported) 1.5 4.1 12.2 -0.3 -0.4 -3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.4 -0.1 0.3 0.7
Illnesses of father: Heart disease 0.8 1.0 3.1 -0.1 0.0 -1.8
Illnesses of siblings: Diabetes 0.1 0.1 0.2 -0.3 -0.4 0.4
Smoking status: Previous 0.7 1.1 3.3 -0.2 1.8 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 2.1 -1.4 1.4 -1.4
Whole body fat-free mass 1.5 8.7 18.7 -4.3 2.7 -0.1
Leg fat-free mass (right) 1.0 5.2 12.5 -3.5 1.7 -0.1
Arm fat percentage (left) 0.3 1.4 3.2 -0.7 -1.8 -0.6
Average weekly red wine intake 0.0 0.0 0.1 0.1 0.1 -0.3
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.4 -0.6 -0.6 0.2
Mood swings 0.1 0.1 0.2 -0.3 0.4 0.3
Loneliness, isolation 0.9 1.2 2.8 -0.4 -1.7 -0.8
Long-standing illness, disability or infirmity 0.4 0.5 1.1 -0.1 -0.7 -1.0
Ever had bowel cancer screening 0.7 0.8 1.8 1.3 -0.1 -0.7
Diabetes diagnosed by doctor 1.8 2.9 6.0 -1.7 2.5 0.0
Ever had stillbirth, spontaneous miscarriage or termination 2.8 3.0 4.8 -2.2 -1.8 1.1
Friendships satisfaction 0.5 0.6 0.9 0.9 -0.9 0.0
Qualifications: nursing, teaching 0.5 0.8 1.1 1.0 -0.5 -1.1
Commuting to job workplace: Walk 1.3 1.4 3.5 -0.8 0.0 1.9
Eye problems/disorders: Cataract 1.1 1.2 2.5 -0.4 1.0 1.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.1 -1.1 -0.4 0.9
Medication for cholesterol 2.1 3.1 5.5 2.3 1.9 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.6 2.1 -1.2 -1.1 1.5
Back pain experienced in last month 1.0 1.4 2.3 1.5 1.3 -0.6
Mineral and other dietary supplements 0.5 0.7 1.4 -0.8 0.2 1.2
Breast cancer (self-reported) 1.2 1.5 2.3 -1.4 -1.5 0.2
Asthma (self-reported) 0.4 0.9 1.8 -0.7 0.6 1.3
Osteoporosis (self-reported) 4.8 6.0 10.2 1.5 -3.2 -2.4
Osteoarthritis (self-reported) 1.0 1.3 2.2 -1.5 -1.3 -0.3
Medication: Aspirin 0.9 1.2 3.2 -0.1 -0.6 -1.8
Medication: Gliclazide 0.3 0.3 0.9 1.0 0.1 0.1
Illnesses of father: None of the above (group 1) 0.4 0.5 0.7 0.9 -0.6 0.6
Smoking status: Current 0.8 1.3 2.0 1.4 -0.2 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.5 7.5 12.2 3.1 -3.5 -0.6
Whole body water mass 1.5 8.4 18.3 -4.3 2.7 -0.0
Leg predicted mass (right) 1.0 5.2 12.7 -3.6 1.7 -0.1
Arm fat mass (left) 0.4 1.7 4.5 -2.1 -0.7 -0.4
Number of self-reported non-cancer illnesses 0.4 0.6 1.4 -1.2 -0.0 -0.7
Average weekly champagne plus white wine intake 0.3 0.4 0.8 0.9 0.7 0.2
Miserableness 0.1 0.3 0.7 -0.8 -0.1 -0.3
Guilty feelings 0.3 0.4 1.1 -1.1 0.0 0.0
Wears glasses or contact lenses 0.4 0.5 1.1 1.0 -0.3 -0.6
Ever taken oral contraceptive pill 0.1 0.1 0.3 -0.2 0.6 -0.0
Hearing aid user 0.6 0.7 1.1 -1.1 -0.6 0.8
Mother’s age at death 1.7 2.2 4.2 1.3 -0.8 -2.0
Financial situation satisfaction 0.5 0.6 1.3 0.6 -0.6 1.1
Tinnitus: Yes, now most or all of the time 1.5 1.7 3.8 -0.2 -1.1 1.9
Commuting to job workplace: Public transport 0.8 1.0 1.5 1.1 0.5 1.2
Eye problems/disorders: Glaucoma 2.5 2.9 4.1 1.5 -1.6 -2.0
Medication: Blood pressure 1.3 2.5 3.8 -1.9 -1.6 -1.0
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.1 -1.0 -0.2 -0.0
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.0 -0.3 1.0 -0.7
High cholesterol (Self-reported) 0.5 1.0 2.4 -0.3 -0.7 -1.6
Medication: Bendroflumethiazide 1.6 2.4 4.1 -1.3 -1.2 -2.0
Medication: Paracetamol 0.4 0.6 1.6 0.5 -1.3 -0.2
Medication: Lisinopril 3.1 4.0 9.2 -1.6 0.5 -3.0
Medication: Atorvastatin 0.4 0.5 1.5 -1.2 0.3 -0.0
Illnesses of father: High blood pressure 0.2 0.2 0.4 -0.4 0.4 -0.6
Alcohol drinker status: Never 0.3 0.4 0.9 -1.0 0.3 0.3
Ever smoked 0.1 0.1 0.3 -0.0 0.6 -0.3
Basal metabolic rate 1.4 7.9 17.6 -4.2 2.5 -0.2
Leg fat percentage (left) 0.6 2.0 2.4 -1.2 -1.4 -1.6
Arm fat-free mass (left) 1.5 7.6 17.7 -4.2 2.3 0.1
Number of operations (self-reported) 0.1 0.1 0.3 0.1 -0.5 0.2
Average weekly beer plus cider intake 1.3 1.8 3.4 -1.4 -1.9 0.0
Irritability 0.4 0.8 1.5 -0.6 -0.6 -1.2
Risk taking 1.7 2.5 5.2 1.5 -2.3 -0.0
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.2 -0.5 0.4 -0.3
Fractured/broken bones in last 5 years 0.6 0.7 2.2 -0.0 0.0 1.5
Age started oral contraceptive pill 0.6 0.8 1.7 0.7 -0.4 -1.3
Diastolic blood pressure, automated reading 1.6 5.0 12.7 0.3 -1.5 -3.6
Ever depressed for a whole week 0.1 0.1 0.1 0.4 -0.0 0.4
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.3 -0.4 0.3
Commuting to job workplace: Cycle 0.4 0.5 0.9 1.0 -0.1 -0.8
Myopia 0.3 0.4 0.8 0.6 0.9 0.4
Vascular/heart problems diagnosed by doctor 1.3 3.4 10.0 -0.1 0.5 3.2
Cholesterol lowering medication 1.1 1.6 2.3 -1.1 -1.1 -1.5
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.9 -1.4 0.4 -1.0
Pain experienced in last month 1.3 2.1 6.3 -0.3 2.5 -0.3
Supplements: Calcium 0.9 1.0 2.2 1.5 0.6 -0.6
Basal cell carcinoma (self-reported) 0.3 0.4 0.6 -0.6 -0.2 0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.8 -1.4 -0.3 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 0.9 -0.8 0.8 1.0
Heart disease (siblings) 0.2 0.2 0.7 0.8 0.2 0.1
Alcohol drinker status: Previous 0.7 0.9 1.7 0.1 0.9 1.3
Pack years of smoking 0.9 1.3 3.8 -0.0 2.0 0.0
Impedance of whole body 0.3 1.8 2.6 1.6 1.6 -0.6
Leg fat mass (left) 0.5 2.0 4.9 -2.2 -0.2 -1.1
Arm predicted mass (left) 1.5 7.8 17.9 -4.2 2.4 -0.0