Hub : Genes

ZNF442

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.149	0.064	0.0043	0.011	NA	0.011	NA	0.018	8.8e-02	NA	0.08400	NA	3.7e-02
2	GTEx	Testis	0.161	0.065	0.0055	0.064	NA	0.020	NA	0.015	8.7e-04	NA	0.04500	NA	6.6e-02
3	TCGA	Thyroid Carcinoma	0.088	0.043	0.0014	0.044	0.046	0.028	NA	0.039	3.7e-05	2.7e-05	0.00091	NA	9.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.8	0.3	0.3
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	-0.5	-0.9	0.5
Depressed Affect (Nagel 2018)	0.7	1.5	2.8	-1.3	-0.0	-1.7
Depression (Nagel 2018)	0.5	0.8	1.3	-1.0	-0.4	-1.1
Intelligence (Savage-Jansen 2018)	2.0	6.2	14.5	-0.9	-1.8	-3.8
Neuroticism (Nagel 2018)	0.6	1.4	2.8	-1.1	-0.5	-1.7
Schizophrenia (2018)	0.3	0.6	1.9	-0.1	-1.4	0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	-0.7	0.3	0.8
Worry (Nagel 2018)	0.2	0.4	0.5	0.4	-0.7	-0.7
Alzheimer’s Disease (in mother)	0.4	0.5	1.4	0.0	1.2	-0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.1	0.1	-0.4
Alzheimer’s Disease (including proxy)	0.4	0.5	1.5	-0.2	1.2	0.2
Crohns Disease (2017)	0.2	0.4	0.8	0.9	0.4	0.5
Irritable Bowel Disease (IBD)	0.4	1.0	1.6	-0.9	0.9	1.3
Ulcerative Colitis (UC)	1.3	2.4	3.2	-1.8	1.4	1.5
Major Depression (MDD)	0.1	0.2	0.3	-0.5	0.1	-0.6
Reaction Time	0.7	1.4	2.5	0.3	1.2	1.6
Verbal and Numeric Reasoning (VNR)	3.1	7.3	15.1	0.7	-2.5	-3.9
Breast Cancer	0.9	2.3	4.5	0.6	1.4	2.1
Ovarian Cancer	0.7	0.9	1.0	0.9	-1.0	-0.9
Prostate Cancer	0.1	0.1	0.1	-0.2	-0.3	-0.3
Age at First Birth	0.5	0.8	2.1	1.5	0.3	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	-0.3	-1.1	-0.5
Coronary Artery Disease (CAD)	0.7	0.9	2.5	-1.6	0.3	0.1
Crohns Disease (2012)	0.3	0.5	0.9	-0.7	0.4	0.9
Mean Putamen Volume	0.8	0.9	1.8	0.3	0.9	1.3
Fasting Glucose	0.5	0.6	1.4	-0.2	0.7	-1.2
HbA1C	0.4	0.4	0.5	0.6	0.6	-0.7
HDL Cholesterol	0.3	0.5	0.9	0.1	0.9	0.8
LDL Cholesterol	0.2	0.2	0.7	0.8	-0.2	0.0
Lupus	1.6	2.4	6.1	0.5	-0.9	-2.5
Neuroticism (2016)	0.6	0.9	1.6	0.8	0.7	-1.3
Primary Biliary Cirrhosis	0.6	0.8	2.5	-0.2	1.6	-0.1
Rheumatoid Arthritis	0.1	0.2	0.3	0.5	0.1	-0.6
Schizophrenia (2014)	0.5	1.1	2.2	-1.0	-1.5	0.4
Triglycerides	0.6	1.0	2.0	-1.4	-0.5	0.9
Type 2 Diabetes (T2D) (2012)	2.0	2.3	4.7	-1.2	2.2	-0.9
Ulcerative Colitis	1.7	2.4	4.2	-2.0	0.1	1.8
Blood Eosinophil Count	0.2	1.5	4.4	-0.1	-2.1	0.5
Blood Platelet Count	0.4	4.8	12.0	-0.7	1.4	-3.5
Blood Red Count	0.8	8.0	9.7	2.2	-3.0	3.1
Blood White Count	0.1	0.4	1.1	-0.0	-1.1	-0.1
Heel T-Score	0.7	5.8	15.2	0.2	-1.5	3.9
BMI	0.3	1.6	2.9	-1.7	-0.9	-1.1
Height	1.9	35.7	68.6	-5.8	8.3	-2.3
Waist Hip Ratio (WHR)	0.7	2.9	4.9	-0.7	2.2	-1.8
Systolic Blood Pressure	0.5	2.6	6.2	-1.1	0.6	-2.5
Smoking Status	0.4	1.0	1.9	0.7	0.8	-1.4
Allergy or Eczema	0.5	1.4	3.1	0.9	-0.6	-1.8
Cardiovascular Disease	1.2	4.1	8.9	-1.7	0.6	-3.0
Hypothyroidism (self reported)	0.7	1.5	4.0	-0.3	-0.7	-2.0
Respiratory disease	1.6	3.5	9.1	-1.1	0.3	3.0
Type 2 Diabetes (T2D) (2018)	2.8	5.2	11.6	-2.0	3.4	-0.4
Lung FEV1/FVC ratio	0.7	3.7	4.2	2.0	-1.7	-2.1
Lung FVC	1.5	7.6	10.9	3.1	-3.3	-1.5
Neuroticism	0.3	0.7	2.0	-0.0	0.4	-1.4
Chronotype (morning person)	0.2	0.6	1.1	0.1	-0.7	-1.1
Hair Pigment	0.0	1.3	2.0	-1.4	-0.9	-1.0
Tanning	0.0	0.4	0.7	0.7	0.9	-0.2
Hand grip strength (left)	1.2	3.1	3.9	-2.0	1.9	1.3
Number of treatments/medications taken	0.8	1.5	4.4	-0.4	-0.1	-2.1
Average weekly spirits intake	1.0	1.2	2.7	-1.6	-1.0	0.3
Sensitivity / hurt feelings	0.2	0.4	0.8	-0.5	0.9	-0.4
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.7	-0.5	-1.1	1.6
Hearing difficulty/problems: Yes	1.8	2.7	7.6	0.1	-2.8	0.7
Relative age of first facial hair	0.4	0.9	1.6	-0.9	0.6	-1.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.0	0.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.0	0.1	0.1	0.3	0.3	0.1
Ever had hysterectomy (womb removed)	2.0	2.3	3.2	-1.7	1.8	1.0
Systolic blood pressure, automated reading	0.8	2.2	6.3	0.4	-0.4	-2.5
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.0	-2.0	1.2	0.5
Angina	0.4	0.6	1.2	1.1	0.3	0.6
Medication for hormone replacement therapy	0.7	0.8	1.7	-0.3	-1.3	0.8
Vitamin and mineral supplements	0.1	0.2	0.4	0.1	0.6	0.4
Supplements: Zinc	0.1	0.1	0.2	-0.1	-0.4	0.4
Medication: Co-codamol	2.0	2.4	3.3	1.8	-1.0	-1.7
Medication: Metformin	1.2	1.7	3.5	-1.9	1.1	0.6
Diabetes (father)	1.1	1.4	2.0	-1.4	1.1	0.9
Diabetes (mother)	2.1	2.7	6.0	-0.2	2.5	1.4
Severe depression (siblings)	0.5	0.5	0.8	-0.3	-0.8	-0.9
Pack years adult smoking proportion	0.8	1.2	3.5	-0.3	1.9	0.1
Impedance of leg (right)	0.4	1.9	5.2	0.4	2.3	-0.6
Leg fat-free mass (left)	1.1	5.9	14.1	-3.8	1.9	-0.2
Trunk fat percentage	0.2	0.7	1.3	-1.2	-0.1	-0.9
Hand grip strength (right)	0.5	1.5	1.7	-1.3	1.1	1.2
Townsend deprivation index at recruitment	1.1	1.5	3.9	0.3	0.7	2.0
Current tobacco smoking	0.7	1.2	1.9	1.3	0.2	-1.4
Average weekly fortified wine intake	0.8	0.9	1.8	1.3	0.7	-0.7
Maternal smoking around birth	1.1	1.6	2.7	0.2	1.6	-1.4
Fed-up feelings	0.9	1.7	3.6	0.0	1.2	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.5	0.0	-0.3
Relative age voice broke	0.8	1.2	1.8	-0.9	1.4	-0.9
Taking other prescription medications	1.0	1.5	2.1	1.4	-0.6	-1.4
Age when periods started (menarche)	1.1	2.6	6.2	-0.7	2.5	-0.9
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	4.4	-1.7	2.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	3.4	-1.9	-1.0	1.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.5	-0.4	0.1
Qualifications: CSEs or equivalent	1.4	1.9	3.4	-1.9	-1.1	-1.0
Serious illness, injury or assault to yourself	1.4	1.6	3.5	-1.9	-1.1	0.6
High blood pressure	1.4	3.9	11.1	-0.4	-0.6	-3.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	-0.4	-1.3	-0.8
Multivitamins +/- minerals	0.7	0.9	2.2	-0.7	-1.5	-0.4
Stomach or abdominal pain in last month	2.5	3.1	4.4	-1.0	-2.0	2.1
Supplements: Glucosamine	0.8	1.1	2.7	-0.5	-1.7	-0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.4	-1.2	-1.0	0.4
Medication: Atenolol	0.9	1.2	2.7	0.7	-0.6	-1.6
Medication: Levothyroxine sodium	1.7	2.9	7.8	0.9	-0.1	-2.8
Sitting height	1.9	13.3	26.5	-3.6	5.1	0.6
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	-1.2	-0.4	0.5
High blood pressure (mother)	0.9	1.2	2.1	-1.2	0.3	-1.5
Body mass index (BMI)	0.4	1.9	3.4	-1.5	-1.8	-0.2
Impedance of leg (left)	0.3	1.5	3.8	0.8	2.0	-0.3
Leg predicted mass (left)	1.1	6.0	14.1	-3.8	2.0	-0.2
Trunk fat mass	0.5	2.2	5.0	-2.2	0.7	-1.0
Waist circumference	0.5	2.0	3.3	-1.8	-0.0	-1.6
Number of incorrect matches in round	6.7	11.2	20.5	0.5	3.6	4.5
Past tobacco smoking	0.3	0.5	1.0	0.0	-1.0	0.6
Alcohol usually taken with meals	0.2	0.4	1.2	-1.1	-0.1	0.1
Nervous feelings	0.2	0.3	0.5	0.7	-0.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.4	-0.7	1.0
Hearing difficulty/problems with background noise	1.3	2.2	5.6	0.0	-0.9	2.4
Hair/balding pattern: Pattern 2	1.9	2.4	6.1	2.5	1.0	0.3
Had menopause	0.4	0.5	1.1	1.0	-0.3	-0.7
Had other major operations	0.4	0.5	0.7	-0.8	0.3	0.9
Forced vital capacity (FVC)	0.2	0.7	1.2	-0.9	0.3	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	4.2	-1.1	-1.1	2.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	0.3	1.0	0.0
Qualifications: None of the above	0.7	1.5	2.4	1.0	1.0	1.6
Financial difficulties in last 2 years	1.4	1.9	4.7	0.9	-2.2	-0.2
Mouth/teeth dental problems	0.5	0.8	2.4	0.3	-0.0	-1.6
Heart attack	0.7	1.0	2.6	-1.6	-0.4	-0.3
Allergy	0.4	0.8	2.0	1.4	0.7	-0.1
Pain all over the body in last month	2.2	2.3	4.5	-2.1	-0.6	1.5
Diabetes (self-reported)	2.6	4.0	7.7	-2.0	2.8	-0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.7	0.9	-0.3
Medication: Ramipril	0.3	0.4	0.7	-0.6	-0.0	-0.8
Medication: Simvastatin	0.3	0.5	1.0	0.1	-0.6	-1.0
Fluid intelligence score	1.6	3.3	7.1	-0.1	-1.7	-2.7
Illnesses of siblings	0.5	0.7	1.3	0.1	1.1	0.8
Neuroticism score	0.0	0.1	0.2	-0.1	0.5	-0.2
Weight	1.0	4.8	11.4	-3.4	1.6	-0.7
Impedance of arm (right)	0.3	1.2	1.6	1.3	0.8	-1.2
Arm fat percentage (right)	0.4	1.5	2.7	-1.1	-1.6	-0.9
Trunk fat-free mass	1.9	11.0	21.0	-4.6	3.5	-0.1
Hip circumference	0.8	3.3	7.7	-2.8	0.3	-1.4
Time employed in main current job	0.0	0.0	0.0	-0.0	0.2	0.1
Alcohol intake versus 10 years previously	0.4	0.7	1.3	-0.6	0.5	-1.2
Father’s age at death	0.1	0.2	0.3	-0.2	0.3	0.6
Worrier / anxious feelings	0.2	0.4	1.3	1.1	0.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	-0.1	-1.0	-0.0
Falls in the last year	0.3	0.4	0.7	0.8	-0.7	0.2
Hair/balding pattern: Pattern 3	0.4	0.5	1.3	-0.2	0.5	1.1
Number of live births	0.1	0.1	0.1	-0.4	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.8	-0.2	-0.5	-1.3
Pulse rate	0.7	1.2	3.5	0.0	0.0	-1.9
Happiness	1.1	1.3	2.2	-1.5	-0.4	-1.3
Noisy workplace	0.9	1.1	1.9	0.3	-1.2	1.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.0	-0.1	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.0	-1.0	-1.0	-0.4
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	0.5	1.3	0.1
Asthma	0.4	0.8	1.8	-0.6	0.3	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.7	-0.3	-1.3	0.3
Medication: Cholesterol lowering	0.6	0.9	1.4	0.7	1.2	-0.8
Depression (self-reported)	0.1	0.1	0.2	0.2	0.0	0.4
Medication: Lansoprazole	0.1	0.1	0.3	-0.3	0.1	0.5
Prospective memory result	0.4	0.5	1.4	0.0	1.2	0.4
Lung cancer (father)	0.9	1.1	2.2	0.6	0.9	1.5
Illnesses of mother	0.5	0.6	1.8	-0.3	-0.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.9	-0.3	-0.7	-1.4
Pulse wave Arterial Stiffness index	0.7	0.8	2.4	-1.5	0.3	0.2
Impedance of arm (left)	0.4	1.9	3.9	2.0	1.2	-0.7
Arm fat mass (right)	0.4	1.8	4.5	-2.1	-0.7	-0.5
Trunk predicted mass	1.8	10.5	20.8	-4.6	3.3	-0.2
Standing height	2.9	28.5	61.3	-4.9	7.8	-0.7
Length of working week for main job	0.1	0.1	0.2	-0.3	-0.4	-0.0
Exposure to tobacco smoke at home	0.4	0.4	1.1	1.1	-0.3	-0.2
Breastfed as a baby	0.5	0.6	0.9	-1.0	-0.3	0.9
Tense / ‘highly strung’	0.2	0.3	0.8	0.9	-0.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.7	0.0	0.4
Hair/balding pattern: Pattern 4	0.3	0.6	1.5	-0.3	-0.5	-1.2
Birth weight of first child	0.8	1.4	2.7	-0.8	0.9	-1.6
Peak expiratory flow (PEF)	0.3	0.8	1.5	-0.6	-1.2	-0.8
Pulse wave reflection index	0.6	0.7	1.4	-1.2	-0.6	0.6
Ever highly irritable/argumentative for 2 days	3.4	4.1	7.1	-2.7	0.6	2.2
Loud music exposure frequency	1.7	1.9	3.7	-1.1	-0.9	1.9
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	3.8	-0.8	-1.9	-1.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	4.0	-0.3	0.7	2.0
Blood clot in the leg (DVT)	0.5	0.7	1.1	-0.5	0.8	1.1
Medication: Paracetamol	1.3	2.2	3.6	1.9	-1.5	-0.9
Headache pain in last month	0.6	1.0	2.9	-0.0	-1.7	-0.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.6	0.3	-1.0	1.6
Glaucoma (self-reported)	1.9	2.2	3.0	1.3	-1.4	-1.7
Gout (self-reported)	0.1	0.1	0.4	0.1	-0.6	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.5	0.3	-0.1	-1.6
Medication: Amlodipine	1.0	1.3	4.0	0.0	2.0	0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.8	-0.3	0.3	0.9
Birth weight	0.4	0.8	1.2	1.1	0.7	-0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	-0.7	-1.2	0.2
High blood pressure (siblings)	0.9	1.3	2.3	-0.7	-1.1	-1.5
Forced vital capacity (FVC), Best measure	0.4	1.4	3.2	-1.0	0.2	-1.8
Body fat percentage	0.2	0.9	1.3	-1.1	-0.6	-1.1
Leg fat percentage (right)	0.6	2.0	2.5	-1.4	-1.3	-1.6
Arm fat-free mass (right)	1.5	7.7	14.5	-3.8	2.9	0.2
Exposure to tobacco smoke outside home	1.0	1.4	3.4	1.8	-0.8	-0.4
Comparative body size at age 10	0.2	0.5	1.0	-0.1	-1.0	-0.6
Number of full brothers	0.3	0.4	1.3	0.2	-0.1	1.1
Worry too long after embarrassment	0.2	0.3	0.8	-0.2	-0.3	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.2	0.2	-0.6
Wheeze or whistling in the chest in last year	0.3	0.4	0.8	-0.5	-0.9	0.6
Number of children fathered	0.6	0.6	1.5	-1.2	0.6	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.0	-0.2	-0.2
Age at first live birth	2.0	3.6	6.6	2.6	1.3	-1.5
Pulse wave peak to peak time	0.5	0.6	1.6	1.3	0.2	-0.2
Health satisfaction	0.8	1.0	2.8	-0.5	-1.7	-0.0
Shortness of breath walking on level ground	0.5	0.6	0.9	-0.9	-0.7	-0.6
Qualifications: College or University degree	0.6	1.8	4.8	0.5	-0.6	-2.2
Eye problems/disorders: None of the above	1.7	2.0	5.4	-0.8	2.3	0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.3	-0.5	0.2
Emphysema/chronic bronchitis	1.7	2.0	3.3	-1.8	0.5	1.5
Medication for pain relief, constipation, heartburn	0.9	1.5	2.6	-0.1	1.4	1.6
Neck or shoulder pain in last month	1.2	1.8	2.2	1.3	-1.1	1.5
Medication: Blood pressure	0.9	1.6	4.0	-0.3	0.8	-2.0
Angina (self-reported)	0.6	0.7	1.1	1.0	0.6	0.9
Migraine (self-reported)	0.4	0.5	0.7	-0.7	0.6	-0.9
Medication: Ibuprofen	0.1	0.1	0.3	0.0	-0.6	0.3
Medication: Allopurinol	0.1	0.2	0.4	-0.2	0.6	-0.2
Medication: Omeprazole	0.9	1.1	3.1	-1.8	0.2	-0.4
Medication: Seretide 50 evohaler	2.8	3.2	8.2	-0.3	1.1	2.9
Mean time to correctly identify matches	0.7	1.3	3.4	1.9	0.6	0.4
Heart disease (mother)	0.4	0.5	0.8	-0.3	-0.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.6	0.8	-0.3	-1.6
Whole body fat mass	0.5	2.1	5.1	-2.3	0.5	-1.0
Leg fat mass (right)	0.6	2.2	5.5	-2.3	-0.2	-1.1
Arm predicted mass (right)	1.5	7.7	15.5	-3.9	2.7	0.5
Pulse rate, automated reading	0.4	1.2	2.2	-0.4	-1.1	-1.5
Alcohol intake frequency.	0.3	0.6	1.6	-1.3	-0.2	-0.4
Comparative height size at age 10	1.2	6.4	12.6	-3.6	2.5	-0.0
Number of full sisters	0.9	1.1	2.3	0.5	0.9	-1.5
Suffer from ‘nerves’	0.4	0.7	1.5	1.2	-0.5	0.5
Overall health rating	0.2	0.5	1.2	0.3	-0.4	-1.1
Chest pain or discomfort	0.6	0.9	2.5	-0.2	-1.6	-0.2
Had major operations	1.7	2.0	3.8	2.0	-1.3	-0.6
Age at last live birth	0.4	0.6	0.8	0.9	0.6	0.8
Family relationship satisfaction	1.8	2.2	5.0	-1.0	-2.2	0.8
Leg pain on walking	2.6	3.3	4.8	1.0	-2.0	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.8	-1.3	-0.7	0.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.3	-0.3	1.0	-1.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.5	0.2	-0.4
Medication: Aspirin	1.4	1.9	4.9	-0.1	-0.8	-2.2
Supplements: Vitamin C	0.6	0.8	1.6	0.5	-0.7	-1.3
Knee pain experienced in last month	0.9	1.4	3.9	0.3	-2.0	0.2
Hypertension (Self-reported)	1.5	4.1	12.2	-0.3	-0.4	-3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	-0.1	0.3	0.7
Illnesses of father: Heart disease	0.8	1.0	3.1	-0.1	0.0	-1.8
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.3	-0.4	0.4
Smoking status: Previous	0.7	1.1	3.3	-0.2	1.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	2.1	-1.4	1.4	-1.4
Whole body fat-free mass	1.5	8.7	18.7	-4.3	2.7	-0.1
Leg fat-free mass (right)	1.0	5.2	12.5	-3.5	1.7	-0.1
Arm fat percentage (left)	0.3	1.4	3.2	-0.7	-1.8	-0.6
Average weekly red wine intake	0.0	0.0	0.1	0.1	0.1	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	-0.6	-0.6	0.2
Mood swings	0.1	0.1	0.2	-0.3	0.4	0.3
Loneliness, isolation	0.9	1.2	2.8	-0.4	-1.7	-0.8
Long-standing illness, disability or infirmity	0.4	0.5	1.1	-0.1	-0.7	-1.0
Ever had bowel cancer screening	0.7	0.8	1.8	1.3	-0.1	-0.7
Diabetes diagnosed by doctor	1.8	2.9	6.0	-1.7	2.5	0.0
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	4.8	-2.2	-1.8	1.1
Friendships satisfaction	0.5	0.6	0.9	0.9	-0.9	0.0
Qualifications: nursing, teaching	0.5	0.8	1.1	1.0	-0.5	-1.1
Commuting to job workplace: Walk	1.3	1.4	3.5	-0.8	0.0	1.9
Eye problems/disorders: Cataract	1.1	1.2	2.5	-0.4	1.0	1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.1	-1.1	-0.4	0.9
Medication for cholesterol	2.1	3.1	5.5	2.3	1.9	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	2.1	-1.2	-1.1	1.5
Back pain experienced in last month	1.0	1.4	2.3	1.5	1.3	-0.6
Mineral and other dietary supplements	0.5	0.7	1.4	-0.8	0.2	1.2
Breast cancer (self-reported)	1.2	1.5	2.3	-1.4	-1.5	0.2
Asthma (self-reported)	0.4	0.9	1.8	-0.7	0.6	1.3
Osteoporosis (self-reported)	4.8	6.0	10.2	1.5	-3.2	-2.4
Osteoarthritis (self-reported)	1.0	1.3	2.2	-1.5	-1.3	-0.3
Medication: Aspirin	0.9	1.2	3.2	-0.1	-0.6	-1.8
Medication: Gliclazide	0.3	0.3	0.9	1.0	0.1	0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	0.7	0.9	-0.6	0.6
Smoking status: Current	0.8	1.3	2.0	1.4	-0.2	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.5	12.2	3.1	-3.5	-0.6
Whole body water mass	1.5	8.4	18.3	-4.3	2.7	-0.0
Leg predicted mass (right)	1.0	5.2	12.7	-3.6	1.7	-0.1
Arm fat mass (left)	0.4	1.7	4.5	-2.1	-0.7	-0.4
Number of self-reported non-cancer illnesses	0.4	0.6	1.4	-1.2	-0.0	-0.7
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.9	0.7	0.2
Miserableness	0.1	0.3	0.7	-0.8	-0.1	-0.3
Guilty feelings	0.3	0.4	1.1	-1.1	0.0	0.0
Wears glasses or contact lenses	0.4	0.5	1.1	1.0	-0.3	-0.6
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.2	0.6	-0.0
Hearing aid user	0.6	0.7	1.1	-1.1	-0.6	0.8
Mother’s age at death	1.7	2.2	4.2	1.3	-0.8	-2.0
Financial situation satisfaction	0.5	0.6	1.3	0.6	-0.6	1.1
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.8	-0.2	-1.1	1.9
Commuting to job workplace: Public transport	0.8	1.0	1.5	1.1	0.5	1.2
Eye problems/disorders: Glaucoma	2.5	2.9	4.1	1.5	-1.6	-2.0
Medication: Blood pressure	1.3	2.5	3.8	-1.9	-1.6	-1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-1.0	-0.2	-0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.3	1.0	-0.7
High cholesterol (Self-reported)	0.5	1.0	2.4	-0.3	-0.7	-1.6
Medication: Bendroflumethiazide	1.6	2.4	4.1	-1.3	-1.2	-2.0
Medication: Paracetamol	0.4	0.6	1.6	0.5	-1.3	-0.2
Medication: Lisinopril	3.1	4.0	9.2	-1.6	0.5	-3.0
Medication: Atorvastatin	0.4	0.5	1.5	-1.2	0.3	-0.0
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.4	0.4	-0.6
Alcohol drinker status: Never	0.3	0.4	0.9	-1.0	0.3	0.3
Ever smoked	0.1	0.1	0.3	-0.0	0.6	-0.3
Basal metabolic rate	1.4	7.9	17.6	-4.2	2.5	-0.2
Leg fat percentage (left)	0.6	2.0	2.4	-1.2	-1.4	-1.6
Arm fat-free mass (left)	1.5	7.6	17.7	-4.2	2.3	0.1
Number of operations (self-reported)	0.1	0.1	0.3	0.1	-0.5	0.2
Average weekly beer plus cider intake	1.3	1.8	3.4	-1.4	-1.9	0.0
Irritability	0.4	0.8	1.5	-0.6	-0.6	-1.2
Risk taking	1.7	2.5	5.2	1.5	-2.3	-0.0
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	-0.5	0.4	-0.3
Fractured/broken bones in last 5 years	0.6	0.7	2.2	-0.0	0.0	1.5
Age started oral contraceptive pill	0.6	0.8	1.7	0.7	-0.4	-1.3
Diastolic blood pressure, automated reading	1.6	5.0	12.7	0.3	-1.5	-3.6
Ever depressed for a whole week	0.1	0.1	0.1	0.4	-0.0	0.4
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.3	-0.4	0.3
Commuting to job workplace: Cycle	0.4	0.5	0.9	1.0	-0.1	-0.8
Myopia	0.3	0.4	0.8	0.6	0.9	0.4
Vascular/heart problems diagnosed by doctor	1.3	3.4	10.0	-0.1	0.5	3.2
Cholesterol lowering medication	1.1	1.6	2.3	-1.1	-1.1	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.9	-1.4	0.4	-1.0
Pain experienced in last month	1.3	2.1	6.3	-0.3	2.5	-0.3
Supplements: Calcium	0.9	1.0	2.2	1.5	0.6	-0.6
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	-0.6	-0.2	0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.8	-1.4	-0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	0.9	-0.8	0.8	1.0
Heart disease (siblings)	0.2	0.2	0.7	0.8	0.2	0.1
Alcohol drinker status: Previous	0.7	0.9	1.7	0.1	0.9	1.3
Pack years of smoking	0.9	1.3	3.8	-0.0	2.0	0.0
Impedance of whole body	0.3	1.8	2.6	1.6	1.6	-0.6
Leg fat mass (left)	0.5	2.0	4.9	-2.2	-0.2	-1.1
Arm predicted mass (left)	1.5	7.8	17.9	-4.2	2.4	-0.0