Hub : Genes

ZNF446

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.1460 0.0650 5.1e-03 0.087 NA 0.049 NA 0.073 9.0e-04 NA 1.1e-02 NA 2.2e-03
2 GTEx Nerve Tibial 0.1217 0.0508 2.8e-03 -0.003 NA 0.010 NA -0.004 6.8e-01 NA 5.9e-02 NA 8.1e-01
3 YFS Blood 0.0202 0.0075 1.6e-05 0.027 0.016 0.024 0.024 0.025 2.0e-09 5.3e-06 1.9e-08 2.5e-08 8.3e-09
4 TCGA Prostate Adenocarcinoma 0.0886 0.0420 1.6e-05 0.028 0.027 0.025 NA 0.027 6.3e-04 7.6e-04 1.0e-03 NA 7.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 2.8 4.4 8.8 0.9 -0.7 2.8 3.0
Bipolar Disorder or Schizophrenia 1.5 3.7 7.1 -0.3 -1.0 2.6 2.7
Depressed Affect (Nagel 2018) 1.3 2.7 4.0 0.5 1.8 -2.0 -1.9
Depression (Nagel 2018) 0.2 0.3 0.7 0.9 -0.4 -0.5 -0.3
Intelligence (Savage-Jansen 2018) 1.5 4.6 8.4 2.9 -1.5 1.6 2.2
Neuroticism (Nagel 2018) 1.1 2.5 4.0 2.0 1.4 -1.6 -1.2
Schizophrenia (2018) 0.5 1.0 1.2 -1.1 -0.7 1.1 1.0
Schizophrenia vs Biploar Disorder 0.4 0.5 0.9 -1.0 -0.3 -0.6 -0.8
Worry (Nagel 2018) 0.9 1.9 5.3 2.3 1.0 -1.0 -0.6
Alzheimer’s Disease (in mother) 0.3 0.3 0.6 -0.8 0.7 0.2 0.2
Alzheimer’s Disease (in father) 0.1 0.1 0.4 0.0 -0.7 0.1 0.1
Alzheimer’s Disease (including proxy) 0.2 0.3 0.8 -0.9 0.0 0.4 0.4
Crohns Disease (2017) 1.8 3.9 6.2 -1.9 -0.4 2.5 2.3
Irritable Bowel Disease (IBD) 1.9 4.6 6.4 -2.5 -0.4 2.5 2.3
Ulcerative Colitis (UC) 1.5 2.8 5.3 -2.3 -0.1 1.8 1.7
Major Depression (MDD) 3.0 3.7 6.0 -1.0 1.4 2.4 2.5
Reaction Time 0.9 1.8 6.4 -2.5 0.7 -0.1 -0.3
Verbal and Numeric Reasoning (VNR) 1.3 3.2 9.5 3.1 -0.8 0.9 1.4
Breast Cancer 0.7 1.8 3.6 0.3 -0.5 1.8 1.9
Ovarian Cancer 1.0 1.3 3.5 1.3 -1.9 0.1 0.2
Prostate Cancer 0.3 0.5 1.3 0.8 -1.1 0.1 0.1
Age at First Birth 0.7 1.0 1.8 -1.3 1.1 -0.6 -0.8
Bipolar Disorder (2011) 3.0 2.9 5.3 -0.3 -1.1 2.2 2.3
Body Mass Index (BMI) (2010) 0.9 1.3 5.1 2.3 0.0 -0.1 0.0
Coronary Artery Disease (CAD) 1.3 1.5 2.0 -1.2 1.2 1.4 1.1
Crohns Disease (2012) 1.5 2.4 2.9 -1.1 -1.7 1.7 1.6
Mean Putamen Volume 0.6 0.7 1.1 -1.0 0.8 -0.6 -0.8
Fasting Glucose 0.1 0.1 0.2 0.1 0.5 0.2 0.2
HbA1C 0.2 0.3 0.8 0.9 0.1 0.4 0.4
HDL Cholesterol 0.3 0.4 1.7 -1.3 -0.1 0.1 -0.1
LDL Cholesterol 0.4 0.6 0.9 0.5 0.7 -0.9 -0.9
Lupus 0.4 0.6 2.2 -1.5 0.5 0.1 -0.0
Neuroticism (2016) 0.9 1.3 1.8 1.2 1.4 -1.0 -0.9
Primary Biliary Cirrhosis 0.6 0.9 1.5 1.2 -0.8 -0.9 -0.8
Rheumatoid Arthritis 0.6 0.8 1.1 0.6 -0.9 -1.0 -1.0
Schizophrenia (2014) 0.8 1.8 3.2 -1.0 -0.2 1.8 1.7
Triglycerides 0.6 1.0 1.6 0.9 1.3 -0.8 -0.8
Type 2 Diabetes (T2D) (2012) 0.5 0.6 0.8 -0.7 -0.9 -0.6 -0.8
Ulcerative Colitis 2.1 3.0 10.3 -3.2 0.6 0.9 0.6
Blood Eosinophil Count 0.3 2.7 5.3 0.5 -0.3 -2.3 -2.3
Blood Platelet Count 4.4 50.7 75.9 8.7 -1.7 -8.2 -7.5
Blood Red Count 0.5 5.2 15.9 4.0 -1.8 -1.0 -0.6
Blood White Count 1.3 9.3 13.5 3.2 -3.7 -2.8 -2.4
Heel T-Score 1.4 11.3 23.5 -0.2 1.5 -4.4 -4.8
BMI 0.1 0.7 1.9 1.4 -0.9 -0.3 -0.1
Height 0.4 7.1 11.2 3.3 0.3 -3.0 -2.9
Waist Hip Ratio (WHR) 0.6 2.7 5.0 -2.2 2.0 1.0 0.9
Systolic Blood Pressure 0.1 0.3 0.5 0.7 -0.2 -0.6 -0.5
Smoking Status 0.1 0.2 0.9 0.9 -0.3 -0.0 0.2
Allergy or Eczema 0.7 1.8 2.5 -1.4 0.8 1.6 1.5
Cardiovascular Disease 0.3 1.0 1.7 1.3 -1.1 0.6 0.9
Hypothyroidism (self reported) 0.6 1.4 1.9 -1.4 0.9 -1.0 -1.4
Respiratory disease 0.7 1.5 5.0 -2.2 0.8 0.4 0.3
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.0 -0.2 -0.5 1.0 1.0
Lung FEV1/FVC ratio 0.0 0.1 0.2 0.3 0.2 -0.4 -0.4
Lung FVC 0.0 0.2 0.4 0.6 -0.2 -0.3 -0.4
Neuroticism 1.1 2.8 4.2 1.9 0.6 -2.1 -1.7
Chronotype (morning person) 3.3 7.6 16.5 -4.1 1.0 2.8 2.3
Hair Pigment 0.2 6.3 10.9 1.9 0.4 -3.3 -3.3
Tanning 0.2 1.9 4.2 -1.9 2.0 0.1 0.0
Hand grip strength (left) 0.9 2.4 4.5 0.8 -0.9 -1.9 -2.1
Number of treatments/medications taken 0.4 0.8 1.7 1.3 -0.1 0.6 1.0
Average weekly spirits intake 0.1 0.1 0.2 -0.1 -0.4 -0.3 -0.4
Sensitivity / hurt feelings 1.2 2.1 8.2 2.9 0.0 -0.5 0.1
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.1 -0.1 0.3 -0.2 -0.1
Hearing difficulty/problems: Yes 4.0 6.1 11.7 1.0 0.5 -3.4 -3.4
Relative age of first facial hair 2.4 4.9 18.1 4.3 -1.1 -0.6 -0.1
Other serious medical condition/disability diagnosed by doctor 3.7 4.8 10.0 -0.4 -0.2 -3.0 -3.2
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.3 -0.8 0.0 1.0 1.1
Ever had hysterectomy (womb removed) 0.4 0.4 1.5 -0.2 1.2 0.2 0.2
Systolic blood pressure, automated reading 0.1 0.3 0.8 0.9 0.1 -0.6 -0.5
Eye problems/disorders: Diabetes related eye disease 2.5 2.7 3.8 -2.0 1.6 1.5 1.6
Angina 2.0 2.6 4.2 -1.2 -0.7 2.0 2.0
Medication for hormone replacement therapy 2.2 2.4 5.0 -0.4 -0.0 2.1 2.2
Vitamin and mineral supplements 3.1 4.1 9.0 -0.3 0.4 -2.7 -3.0
Supplements: Zinc 2.8 3.0 5.9 -0.5 0.1 2.4 2.4
Medication: Co-codamol 0.5 0.6 1.2 -0.0 -1.1 0.7 0.8
Medication: Metformin 0.7 0.9 1.9 -0.0 1.4 0.9 1.0
Diabetes (father) 2.1 2.6 5.1 -0.0 -0.5 2.3 2.2
Diabetes (mother) 0.9 1.2 2.1 1.5 0.9 0.9 1.0
Severe depression (siblings) 4.7 5.2 9.1 -1.6 0.4 3.0 3.0
Pack years adult smoking proportion 0.1 0.1 0.2 -0.4 0.2 -0.4 -0.4
Impedance of leg (right) 0.3 1.5 4.8 -0.8 2.2 -0.5 -0.5
Leg fat-free mass (left) 0.2 1.0 3.8 2.0 -0.5 0.0 0.2
Trunk fat percentage 0.4 1.6 3.9 2.0 0.0 -1.2 -0.9
Hand grip strength (right) 1.1 2.9 5.1 1.4 -0.4 -2.1 -2.3
Townsend deprivation index at recruitment 0.2 0.3 0.7 -0.8 0.9 0.1 0.0
Current tobacco smoking 0.7 1.1 2.1 -0.5 0.1 -1.4 -1.4
Average weekly fortified wine intake 1.3 1.5 3.3 1.2 -1.8 -0.8 -0.7
Maternal smoking around birth 0.2 0.2 0.5 0.7 0.4 0.3 0.5
Fed-up feelings 0.3 0.6 1.3 -0.5 1.1 -0.7 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 0.1 -0.2 0.3 0.4
Relative age voice broke 3.1 4.8 14.0 3.7 -2.0 -1.0 -0.4
Taking other prescription medications 0.5 0.7 1.0 -0.8 0.7 0.9 1.0
Age when periods started (menarche) 2.0 4.9 15.8 4.0 -1.1 -1.4 -0.8
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.9 0.1 1.0 0.1 0.2
Heel bone mineral density (BMD) T-score, automated (left) 2.6 5.8 8.6 2.4 0.6 -2.9 -2.9
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.5 1.2 -0.7 -0.2 -0.2
Qualifications: CSEs or equivalent 3.7 4.8 8.5 -1.6 0.5 2.9 2.8
Serious illness, injury or assault to yourself 1.4 1.7 5.1 -2.3 1.1 -0.4 -0.6
High blood pressure 0.5 1.4 2.3 1.1 0.7 1.3 1.5
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.3 -0.9 0.8 1.5 1.5
Multivitamins +/- minerals 2.7 3.5 7.3 -0.4 0.7 2.5 2.7
Stomach or abdominal pain in last month 1.8 2.2 3.7 1.3 -0.7 1.7 1.9
Supplements: Glucosamine 0.9 1.1 2.0 -0.1 1.0 1.2 1.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.0 -1.0 0.6 0.1 0.0
Medication: Atenolol 1.1 1.4 2.6 0.8 0.6 1.5 1.6
Medication: Levothyroxine sodium 1.2 2.0 4.3 -0.3 0.2 -1.9 -2.1
Sitting height 0.4 2.6 3.9 1.7 -0.1 -2.0 -1.9
Chronic bronchitis/emphysema (father) 0.2 0.2 0.5 -0.7 0.7 0.0 -0.1
High blood pressure (mother) 3.3 4.6 8.7 -1.0 0.7 2.9 3.0
Body mass index (BMI) 0.2 0.7 1.6 1.1 -1.3 -0.2 0.0
Impedance of leg (left) 0.3 1.4 4.4 -0.8 2.1 -0.6 -0.6
Leg predicted mass (left) 0.2 1.0 3.6 1.9 -0.5 0.0 0.2
Trunk fat mass 0.4 1.8 4.6 2.1 -0.1 -1.3 -0.9
Waist circumference 0.1 0.3 1.0 1.0 -0.1 -0.1 0.1
Number of incorrect matches in round 0.3 0.5 0.8 -0.6 0.3 -0.8 -0.9
Past tobacco smoking 1.2 2.2 4.7 -0.7 0.1 -1.9 -2.2
Alcohol usually taken with meals 0.6 1.0 3.7 -1.9 -0.2 0.5 0.4
Nervous feelings 0.9 1.7 2.3 0.9 1.4 -1.5 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.5 0.7 0.4 -0.4 -0.1
Hearing difficulty/problems with background noise 1.2 1.9 3.6 0.9 0.1 -1.9 -1.8
Hair/balding pattern: Pattern 2 1.0 1.2 2.5 -0.3 0.1 1.5 1.6
Had menopause 0.7 0.9 1.8 0.3 0.4 -1.3 -1.3
Had other major operations 1.4 1.7 3.2 1.8 -1.5 -0.9 -0.7
Forced vital capacity (FVC) 0.4 1.5 5.2 2.3 -0.5 -0.7 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 5.4 1.0 1.0 -2.3 -2.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.8 -0.9 0.5 0.7 0.7
Qualifications: None of the above 0.5 1.2 1.7 -1.2 1.3 -0.8 -0.9
Financial difficulties in last 2 years 0.1 0.2 0.7 -0.8 -0.0 0.2 0.0
Mouth/teeth dental problems 0.1 0.2 0.4 0.3 0.2 -0.6 -0.6
Heart attack 0.2 0.3 0.8 0.1 -0.9 0.5 0.5
Allergy 1.0 2.4 3.0 1.5 -1.2 -1.7 -1.6
Pain all over the body in last month 1.3 1.4 3.1 0.0 0.1 1.6 1.8
Diabetes (self-reported) 0.9 1.5 2.8 -0.5 -0.2 1.7 1.7
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.3 -0.2 1.5 1.1 1.1
Medication: Ramipril 0.8 1.1 2.2 0.1 -0.5 1.4 1.5
Medication: Simvastatin 0.5 0.8 1.1 -0.2 -1.0 -1.0 -1.0
Fluid intelligence score 1.4 2.8 6.7 2.6 -1.4 0.9 1.4
Illnesses of siblings 0.9 1.3 2.8 0.5 -1.7 -0.9 -1.0
Neuroticism score 1.3 2.7 3.8 1.3 1.6 -1.9 -1.6
Weight 0.3 1.4 4.2 2.0 -0.5 -0.9 -0.6
Impedance of arm (right) 0.1 0.4 0.6 0.2 0.8 0.5 0.7
Arm fat percentage (right) 0.1 0.5 1.6 1.3 -0.7 -0.3 -0.1
Trunk fat-free mass 0.1 0.6 1.4 1.2 -0.2 -0.7 -0.6
Hip circumference 0.3 1.4 4.0 2.0 -1.1 -0.4 -0.1
Time employed in main current job 0.3 0.3 1.1 -1.0 -0.1 0.4 0.3
Alcohol intake versus 10 years previously 0.3 0.5 0.9 -0.3 0.4 0.9 1.0
Father’s age at death 0.9 1.2 2.0 0.9 -0.4 -1.4 -1.3
Worrier / anxious feelings 0.1 0.3 0.5 0.5 0.7 -0.6 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 0.0 0.7 -0.5 -0.3
Falls in the last year 0.1 0.1 0.2 -0.3 -0.5 -0.3 -0.4
Hair/balding pattern: Pattern 3 0.5 0.7 2.0 -0.9 1.4 -0.1 -0.1
Number of live births 0.6 0.8 1.5 1.2 -0.4 -1.0 -0.8
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 4.7 2.2 -0.7 -0.8 -0.7
Pulse rate 0.5 0.9 1.7 0.2 0.4 -1.3 -1.3
Happiness 0.5 0.6 1.4 -0.7 1.2 0.6 0.4
Noisy workplace 0.2 0.2 0.4 -0.1 0.6 -0.4 -0.5
Qualifications: A levels/AS levels or equivalent 0.8 1.8 5.7 2.4 -1.2 0.1 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 0.2 -0.4 -0.3 -0.4
Mouth/teeth dental problems: Dentures 0.3 0.6 2.3 -0.2 1.5 0.0 -0.0
Asthma 0.9 1.8 2.6 -1.6 1.1 1.3 1.2
Medication: Ibuprofen (e.g. Nurofen) 2.3 2.9 3.7 -1.4 1.6 1.8 1.9
Medication: Cholesterol lowering 0.6 1.0 1.3 0.3 -1.1 -1.1 -1.1
Depression (self-reported) 1.2 1.4 3.4 1.8 -1.2 0.4 0.8
Medication: Lansoprazole 1.5 1.7 2.2 0.9 -1.5 -1.4 -1.4
Prospective memory result 1.9 2.3 5.4 -2.3 1.0 1.3 1.1
Lung cancer (father) 0.2 0.2 0.4 0.6 0.6 0.0 -0.0
Illnesses of mother 1.6 2.0 3.7 0.4 -0.9 -1.9 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 3.7 1.9 0.1 -0.9 -0.8
Pulse wave Arterial Stiffness index 0.1 0.1 0.2 0.4 -0.1 0.4 0.4
Impedance of arm (left) 0.1 0.3 0.5 0.7 0.6 -0.4 -0.2
Arm fat mass (right) 0.2 0.7 2.3 1.5 -0.6 -0.4 -0.2
Trunk predicted mass 0.1 0.5 1.4 1.2 -0.2 -0.6 -0.5
Standing height 0.3 2.6 4.9 2.2 1.2 -1.5 -1.3
Length of working week for main job 3.1 3.4 5.9 -2.4 0.7 2.0 1.8
Exposure to tobacco smoke at home 0.3 0.3 0.6 0.6 -0.8 0.3 0.5
Breastfed as a baby 0.6 0.7 1.2 0.6 -0.5 -1.1 -1.0
Tense / ‘highly strung’ 0.6 1.0 2.6 1.0 1.6 0.1 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 3.8 5.8 8.0 -1.1 2.8 2.6 2.7
Hair/balding pattern: Pattern 4 1.2 2.8 3.3 1.5 -1.7 -1.7 -1.8
Birth weight of first child 2.4 4.4 6.2 2.2 -1.2 -2.5 -2.3
Peak expiratory flow (PEF) 0.8 1.8 6.4 2.5 -0.9 0.0 0.2
Pulse wave reflection index 1.0 1.2 2.1 0.2 -0.9 1.4 1.5
Ever highly irritable/argumentative for 2 days 1.4 1.6 2.5 -1.3 0.1 1.5 1.6
Loud music exposure frequency 0.2 0.2 0.4 0.6 -0.6 -0.3 -0.1
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 4.0 1.9 0.2 1.6 2.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.2 -0.4 0.4 0.3 0.3
Blood clot in the leg (DVT) 0.4 0.5 0.9 -0.5 -1.0 -0.6 -0.8
Medication: Paracetamol 1.4 2.3 4.1 -0.8 -0.4 2.0 2.0
Headache pain in last month 2.4 4.1 8.6 -0.7 -0.3 2.7 2.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.9 -0.9 0.5 0.4 0.4
Glaucoma (self-reported) 1.2 1.4 5.4 -2.3 -0.6 0.1 -0.0
Gout (self-reported) 1.0 1.4 2.7 -0.6 -0.1 1.5 1.6
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 3.1 -0.4 0.1 -1.5 -1.8
Medication: Amlodipine 1.2 1.7 4.1 0.7 2.0 -1.1 -1.0
Medication: Ventolin 100micrograms inhaler 1.3 1.7 2.9 -1.1 -1.7 1.2 1.1
Birth weight 1.9 4.1 6.3 1.6 -1.3 -2.5 -2.5
Chronic bronchitis/emphysema (mother) 1.4 1.7 4.0 -1.4 2.0 0.7 0.5
High blood pressure (siblings) 0.2 0.3 1.2 -0.1 1.1 -0.1 0.1
Forced vital capacity (FVC), Best measure 0.3 1.1 3.1 1.7 0.2 -0.9 -0.8
Body fat percentage 0.3 1.3 2.9 1.7 -0.1 -1.2 -0.9
Leg fat percentage (right) 0.2 0.7 1.3 0.7 0.2 -1.1 -0.9
Arm fat-free mass (right) 0.1 0.6 1.5 1.2 0.1 -0.7 -0.6
Exposure to tobacco smoke outside home 0.1 0.2 0.5 0.4 0.7 -0.2 -0.2
Comparative body size at age 10 0.3 0.9 3.0 1.7 -0.3 -0.5 -0.3
Number of full brothers 0.7 0.8 1.7 -1.3 0.2 -0.8 -1.0
Worry too long after embarrassment 1.7 2.9 4.5 2.1 -0.9 -2.0 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 2.8 3.6 4.8 -1.4 2.2 1.9 2.0
Wheeze or whistling in the chest in last year 3.2 5.7 6.9 -2.5 1.7 2.6 2.6
Number of children fathered 0.3 0.4 0.6 0.7 -0.4 -0.7 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.8 -0.1 -0.9 -0.2 -0.3
Age at first live birth 0.1 0.1 0.4 -0.7 -0.2 0.2 0.1
Pulse wave peak to peak time 0.2 0.3 0.4 -0.5 0.2 -0.6 -0.6
Health satisfaction 0.9 1.2 4.2 -2.1 0.4 0.6 0.4
Shortness of breath walking on level ground 0.1 0.2 0.3 -0.5 0.2 -0.4 -0.4
Qualifications: College or University degree 0.6 2.0 2.3 1.1 -1.5 -1.5 -1.5
Eye problems/disorders: None of the above 2.1 2.5 5.3 2.3 -1.5 -1.1 -1.0
Mouth/teeth dental problems: Loose teeth 1.9 2.2 4.2 -0.6 -0.7 2.0 2.0
Emphysema/chronic bronchitis 1.7 1.9 5.4 -1.4 2.3 -0.3 -0.4
Medication for pain relief, constipation, heartburn 1.0 1.7 3.8 1.9 -1.0 -1.0 -1.0
Neck or shoulder pain in last month 0.1 0.2 0.3 0.3 0.6 0.4 0.4
Medication: Blood pressure 0.2 0.3 0.7 0.8 -0.1 0.5 0.5
Angina (self-reported) 1.7 2.3 3.4 -1.3 -0.9 1.9 1.8
Migraine (self-reported) 0.3 0.3 0.5 0.3 0.7 0.5 0.7
Medication: Ibuprofen 1.2 1.5 2.4 -0.7 1.6 1.1 1.3
Medication: Allopurinol 1.5 2.0 4.0 -0.6 0.3 1.9 2.0
Medication: Omeprazole 0.5 0.6 0.8 -0.5 0.9 -0.8 -0.8
Medication: Seretide 50 evohaler 0.7 0.7 1.3 -0.7 1.1 0.8 0.7
Mean time to correctly identify matches 1.5 2.8 3.8 -2.0 1.7 -1.4 -1.6
Heart disease (mother) 0.4 0.5 1.3 0.4 -1.1 -0.5 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.6 0.7 -1.3 0.8 0.8
Whole body fat mass 0.3 1.4 3.5 1.9 -0.3 -1.2 -0.9
Leg fat mass (right) 0.2 0.7 1.6 1.3 -0.3 -0.8 -0.6
Arm predicted mass (right) 0.1 0.5 1.3 1.1 -0.0 -0.6 -0.5
Pulse rate, automated reading 0.0 0.1 0.2 -0.2 -0.0 -0.4 -0.3
Alcohol intake frequency. 0.7 1.7 2.9 1.1 -0.6 1.6 1.7
Comparative height size at age 10 0.2 1.1 2.3 -0.3 1.5 -0.9 -1.1
Number of full sisters 1.1 1.4 3.3 -1.5 1.8 0.4 0.2
Suffer from ‘nerves’ 0.7 1.0 1.7 1.2 0.2 -1.3 -0.9
Overall health rating 0.1 0.3 0.5 -0.5 0.3 0.5 0.7
Chest pain or discomfort 0.9 1.2 2.2 -0.6 0.7 1.4 1.5
Had major operations 0.4 0.5 0.9 -0.9 0.3 0.7 0.7
Age at last live birth 0.5 0.8 1.1 -1.1 -1.0 0.8 0.6
Family relationship satisfaction 1.3 1.6 2.4 -1.3 -0.4 1.5 1.5
Leg pain on walking 0.8 1.1 2.0 0.2 -0.5 -1.4 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 1.2 -0.2 -1.0 1.1 1.0
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 0.4 -0.3 0.6 0.6
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 1.1 0.1 0.5 0.6
Medication: Aspirin 0.4 0.5 0.8 -0.6 -0.9 0.7 0.7
Supplements: Vitamin C 4.2 5.0 8.9 -0.5 -1.4 2.9 3.0
Knee pain experienced in last month 0.6 0.9 1.6 -0.5 0.4 1.2 1.2
Hypertension (Self-reported) 0.6 1.5 3.1 0.5 0.4 1.6 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.5 0.2 -1.2 -0.8 -0.8
Illnesses of father: Heart disease 0.2 0.3 0.6 0.5 0.1 0.6 0.8
Illnesses of siblings: Diabetes 1.3 1.5 3.2 0.5 1.8 1.1 1.2
Smoking status: Previous 1.3 1.9 4.2 0.6 -0.2 1.8 2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.1 0.6 1.1 -0.1 -0.1
Whole body fat-free mass 0.1 0.7 2.5 1.6 -0.3 -0.4 -0.3
Leg fat-free mass (right) 0.2 0.9 3.0 1.7 -0.6 0.1 0.3
Arm fat percentage (left) 0.2 0.9 2.3 1.5 -0.9 -0.7 -0.4
Average weekly red wine intake 0.6 1.0 2.4 -0.9 1.5 -0.4 -0.6
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.8 -0.9 0.1 0.1 0.0
Mood swings 1.4 2.5 4.0 1.4 1.0 -2.0 -1.8
Loneliness, isolation 0.3 0.4 0.9 -0.4 0.9 0.4 0.6
Long-standing illness, disability or infirmity 0.1 0.2 0.3 -0.5 0.2 0.4 0.5
Ever had bowel cancer screening 0.8 0.9 1.7 -1.2 1.3 0.5 0.6
Diabetes diagnosed by doctor 1.1 1.9 3.7 -0.3 -0.3 1.9 1.9
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.3 -0.3 0.4 1.5 1.5
Friendships satisfaction 1.6 2.0 3.0 -1.7 -1.1 1.5 1.3
Qualifications: nursing, teaching 0.4 0.7 2.2 0.3 -1.5 0.4 0.4
Commuting to job workplace: Walk 0.5 0.6 1.0 -1.0 0.7 -0.5 -0.7
Eye problems/disorders: Cataract 5.6 6.5 8.0 -2.5 2.1 2.8 2.7
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 6.7 0.9 -2.6 1.5 1.7
Medication for cholesterol 2.2 3.4 4.5 1.4 -1.7 -2.0 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.7 0.3 1.6 1.0 1.3
Back pain experienced in last month 1.0 1.4 2.9 0.7 1.7 -1.1 -1.0
Mineral and other dietary supplements 0.2 0.3 0.6 -0.8 -0.3 -0.4 -0.6
Breast cancer (self-reported) 1.3 1.5 2.4 -1.6 -0.5 1.4 1.2
Asthma (self-reported) 1.3 2.5 3.3 -1.8 1.2 1.7 1.6
Osteoporosis (self-reported) 0.8 1.0 2.5 1.6 -0.2 0.6 1.0
Osteoarthritis (self-reported) 1.8 2.3 5.8 -2.4 1.6 -0.6 -0.8
Medication: Aspirin 0.5 0.6 2.3 -0.2 -1.5 0.1 0.1
Medication: Gliclazide 0.1 0.1 0.5 -0.1 0.7 0.1 0.1
Illnesses of father: None of the above (group 1) 0.3 0.4 0.6 0.3 -0.5 -0.7 -0.7
Smoking status: Current 0.5 0.9 1.7 -0.4 0.3 -1.2 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 1.1 1.0 -0.4 -0.1 -0.1
Whole body water mass 0.1 0.6 2.0 1.4 -0.3 -0.4 -0.3
Leg predicted mass (right) 0.2 0.9 3.2 1.8 -0.6 0.2 0.4
Arm fat mass (left) 0.2 0.8 1.9 1.4 -0.7 -0.7 -0.5
Number of self-reported non-cancer illnesses 0.3 0.5 0.7 0.2 -0.8 -0.8 -0.8
Average weekly champagne plus white wine intake 0.8 1.1 1.6 -1.3 1.2 0.8 0.7
Miserableness 1.2 2.1 7.9 -0.5 2.8 -0.3 -0.2
Guilty feelings 0.2 0.3 0.7 -0.5 0.8 0.3 0.4
Wears glasses or contact lenses 0.4 0.5 0.7 0.5 -0.8 0.7 0.8
Ever taken oral contraceptive pill 2.6 2.9 5.9 -0.3 0.2 2.4 2.4
Hearing aid user 0.2 0.2 0.3 -0.1 0.3 -0.6 -0.5
Mother’s age at death 0.4 0.5 0.6 -0.7 0.8 -0.6 -0.7
Financial situation satisfaction 1.7 2.1 3.1 -1.5 0.4 1.8 1.7
Tinnitus: Yes, now most or all of the time 1.6 1.8 2.8 -0.9 1.3 -1.5 -1.7
Commuting to job workplace: Public transport 0.1 0.1 0.3 -0.6 -0.1 -0.2 -0.2
Eye problems/disorders: Glaucoma 2.3 2.7 9.9 -3.2 0.3 0.8 0.5
Medication: Blood pressure 1.1 2.1 4.0 -0.9 2.0 1.3 1.4
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.3 0.2 -0.2 -0.6 -0.5
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.3 1.1 0.2 -0.1 0.0
High cholesterol (Self-reported) 0.4 0.7 1.4 0.1 -0.0 -1.2 -1.2
Medication: Bendroflumethiazide 0.6 1.0 3.7 -0.2 1.9 0.3 0.2
Medication: Paracetamol 1.5 2.3 4.3 -0.8 0.5 2.0 2.1
Medication: Lisinopril 0.6 0.8 1.8 1.3 -0.7 -0.7 -0.6
Medication: Atorvastatin 0.3 0.3 0.7 -0.8 0.7 0.3 0.2
Illnesses of father: High blood pressure 0.5 0.7 1.9 -0.2 1.4 -0.6 -0.7
Alcohol drinker status: Never 2.5 3.0 6.1 0.5 0.8 2.3 2.5
Ever smoked 1.8 3.1 6.4 1.1 -0.6 2.1 2.5
Basal metabolic rate 0.1 0.8 2.7 1.6 -0.3 -0.4 -0.3
Leg fat percentage (left) 0.2 0.7 1.3 0.9 0.1 -1.1 -0.9
Arm fat-free mass (left) 0.0 0.2 0.5 0.7 0.2 -0.5 -0.4
Number of operations (self-reported) 0.3 0.4 0.9 -0.2 0.1 0.9 0.9
Average weekly beer plus cider intake 0.7 0.9 1.4 -0.7 1.2 1.0 1.0
Irritability 0.9 1.6 4.7 0.8 2.2 0.6 0.9
Risk taking 1.2 1.8 2.7 -1.0 1.1 1.6 1.5
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.6 0.2 -0.6 -1.2 -1.3
Fractured/broken bones in last 5 years 1.3 1.7 2.4 -1.6 0.9 1.4 1.3
Age started oral contraceptive pill 1.3 1.6 2.5 1.3 0.1 -1.6 -1.5
Diastolic blood pressure, automated reading 0.2 0.7 1.0 1.0 0.2 -0.9 -1.0
Ever depressed for a whole week 0.6 0.7 1.4 -0.2 1.2 -0.9 -0.8
Unable to work because of sickness or disability 0.7 0.9 1.7 -0.4 0.3 1.2 1.3
Commuting to job workplace: Cycle 2.8 3.3 7.2 -1.8 2.7 1.2 1.2
Myopia 2.7 3.9 5.5 1.6 -1.9 2.0 2.4
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.0 -1.0 -0.1 -1.2 -1.4
Cholesterol lowering medication 0.3 0.5 0.9 -1.0 0.5 -0.5 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.0 -0.2 0.2 -0.2 -0.1
Pain experienced in last month 1.2 2.0 3.0 1.0 -1.1 -1.7 -1.7
Supplements: Calcium 4.6 5.1 10.2 0.4 -0.9 3.0 3.2
Basal cell carcinoma (self-reported) 1.7 2.0 2.6 -1.6 0.9 1.6 1.5
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.1 0.3 -1.1 0.3 0.4
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.2 -0.6 -1.1 -0.3 -0.5
Heart disease (siblings) 0.4 0.4 1.6 -0.2 1.3 -0.2 -0.2
Alcohol drinker status: Previous 0.1 0.2 0.2 0.3 -0.2 0.5 0.5
Pack years of smoking 0.0 0.1 0.1 -0.2 0.3 -0.2 -0.2
Impedance of whole body 0.1 0.6 2.0 0.1 1.4 -0.5 -0.4
Leg fat mass (left) 0.2 0.6 1.4 1.2 -0.3 -0.8 -0.6
Arm predicted mass (left) 0.1 0.5 1.1 1.0 0.2 -0.6 -0.6