TWAS hub - ZNF487

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0940	0.0470	2.3e-03	0.035	0.037	0.020	NA	0.027	6.2e-04	4.2e-04	6.9e-03	NA	2.3e-03
2	TCGA	Breast Invasive Carcinoma	0.0227	0.0120	5.4e-03	0.003	0.008	0.008	NA	0.003	6.7e-02	7.5e-03	6.9e-03	NA	8.1e-02
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0388	0.0217	8.3e-03	-0.001	0.013	0.003	NA	0.002	4.2e-01	1.2e-02	1.5e-01	NA	1.6e-01
4	TCGA	Brain Lower Grade Glioma	0.0406	0.0226	4.0e-03	0.010	0.012	0.012	NA	0.013	2.4e-02	1.5e-02	1.3e-02	NA	1.0e-02
5	TCGA	Pancreatic Adenocarcinoma	0.0990	0.0560	5.6e-03	0.009	0.029	0.021	NA	0.003	1.3e-01	2.3e-02	4.5e-02	NA	2.3e-01
6	TCGA	Prostate Adenocarcinoma	0.1059	0.0463	2.8e-05	0.025	0.044	0.029	NA	0.046	1.0e-03	2.1e-05	5.1e-04	NA	1.2e-05
7	TCGA	Thyroid Carcinoma	0.0970	0.0390	1.6e-05	0.070	0.064	0.052	NA	0.065	2.5e-07	7.0e-07	8.5e-06	NA	6.1e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Medication for pain relief, constipation, heartburn	6.2	10.6	18.6	-4.3	-3.6	-3.1	-1.7	-1.4	-3.1	-4.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.6	6.5	13.6	-3.7	-3.0	-1.9	-1.8	-1.4	-2.5	-2.9
Medication: Ibuprofen (e.g. Nurofen)	5.2	6.6	13.5	3.7	2.5	2.1	1.5	0.9	2.6	3.5
Number of treatments/medications taken	4.3	7.8	12.2	2.5	3.5	3.0	2.5	3.0	2.8	2.2
Medication: Ibuprofen	4.1	4.9	11.7	3.4	2.0	1.8	1.1	0.4	2.1	3.1
Medication: Paracetamol	3.7	6.1	11.8	2.7	2.5	3.4	0.3	1.4	1.8	3.4
Medication for cholesterol, blood pressure or diabetes	3.4	5.6	9.4	-1.4	-3.1	-2.7	-2.0	-2.8	-2.4	-1.8
Hearing difficulty/problems: Yes	3.2	4.8	9.0	-1.5	-2.2	-1.0	-2.9	-3.0	-2.6	-1.0
Medication: Aspirin	3.2	4.1	6.4	2.4	2.2	0.5	2.5	1.5	2.5	1.8
Medication: Omeprazole (e.g. Zanprol)	3.0	3.7	5.5	-2.3	-2.3	-1.8	-1.3	-2.3	-1.6	-1.5
Allergy or Eczema	2.9	7.6	14.0	-2.4	-3.3	-3.7	-0.6	-2.3	-2.0	-3.5
Number of full brothers	2.8	3.5	4.9	-1.2	-2.1	-1.6	-2.1	-2.2	-2.2	-1.3
Medication: Blood pressure	2.7	4.8	8.0	1.7	2.8	2.2	1.9	2.2	2.3	2.0
Medication for hormone replacement therapy	2.4	2.7	4.8	1.4	1.8	0.9	2.2	1.4	2.1	1.2
Had menopause	2.4	3.0	5.4	-2.1	-1.8	-1.7	-1.2	-0.6	-1.9	-2.3
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	5.4	-2.2	-2.3	-1.5	-1.2	-0.5	-1.6	-1.9
Medication: Aspirin	2.4	3.2	5.6	1.9	1.9	0.6	2.4	1.3	2.3	1.4
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	8.6	0.9	1.9	2.9	1.0	1.8	1.9	2.3
Average weekly red wine intake	2.3	3.3	5.0	-2.1	-2.1	-1.9	-1.0	-1.4	-1.7	-2.2
Irritability	2.3	3.9	12.4	-3.5	-2.5	-1.2	-1.0	-1.4	-1.2	-1.7
Schizophrenia vs Biploar Disorder	2.2	2.8	6.3	-1.9	-2.2	-2.5	0.2	-1.0	-0.8	-1.9
Medication: Metformin	2.2	3.1	7.8	-1.6	-2.3	-2.8	-0.4	-2.1	-0.8	-0.8
Chronic bronchitis/emphysema (mother)	2.2	2.6	5.1	1.3	1.6	0.4	2.1	0.9	2.3	1.7
Illnesses of father: High blood pressure	2.1	2.6	5.4	-1.0	-2.3	-1.9	-0.5	-1.1	-1.2	-2.3
Ever had hysterectomy (womb removed)	2.0	2.3	3.9	1.1	1.6	0.6	2.0	1.8	1.9	1.1
Had other major operations	2.0	2.5	8.8	-2.3	-0.8	-1.3	0.5	0.4	-0.8	-3.0
Falls in the last year	2.0	2.8	9.6	2.0	0.8	1.4	-1.1	-1.2	0.5	3.1
Primary Biliary Cirrhosis	1.9	2.8	4.6	1.8	1.9	0.1	2.1	1.8	1.8	1.1
Townsend deprivation index at recruitment	1.9	2.6	4.4	2.0	1.2	-0.6	2.1	-0.5	2.1	1.9
Eye problems/disorders: Cataract	1.9	2.2	4.7	1.7	1.2	-0.0	2.2	1.1	2.0	1.1
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.9	-0.9	-0.8	0.9	-2.6	-1.5	-2.0	-0.0
Crohns Disease (2017)	1.8	3.9	13.8	-0.8	2.1	2.6	1.0	3.7	0.7	-0.5
Type 2 Diabetes (T2D) (2018)	1.8	3.4	7.5	-1.2	-2.4	-2.7	-0.9	-2.4	-1.2	-1.0
Relative age of first facial hair	1.8	3.8	8.0	-0.8	-1.8	-1.4	-2.8	-1.9	-2.8	-1.3
Hearing difficulty/problems with background noise	1.8	2.9	5.9	-1.7	-2.0	-2.4	-0.8	-1.6	-1.4	-1.4
LDL Cholesterol	1.7	2.7	4.3	-1.2	-1.3	-1.9	-1.5	-1.4	-1.9	-2.1
Neuroticism (2016)	1.7	2.4	3.7	1.5	1.6	1.6	1.1	1.9	1.5	1.5
Vitamin and mineral supplements	1.7	2.3	5.3	-1.7	-1.1	0.2	-2.3	-1.1	-2.1	-1.2
Diabetes (self-reported)	1.7	2.6	5.9	-2.1	-2.1	-2.4	-0.4	-1.4	-0.9	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	8.4	-0.4	1.6	1.1	1.8	2.9	1.6	0.6
Medication: Bendroflumethiazide	1.7	2.5	7.2	-2.7	-1.9	-1.0	-0.2	-0.6	-0.9	-2.1
Multivitamins +/- minerals	1.6	2.0	4.9	0.8	1.1	0.1	2.2	1.7	1.9	0.9
Average weekly champagne plus white wine intake	1.6	2.3	5.9	1.0	1.9	0.4	1.8	2.4	1.4	0.2
Financial situation satisfaction	1.6	2.0	3.6	0.9	1.4	0.6	1.9	1.8	1.8	1.1
Blood Platelet Count	1.5	17.5	39.8	-3.7	-3.9	-0.9	-6.3	-4.3	-5.5	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	10.1	-1.2	-1.9	-3.2	0.3	-1.6	-0.9	-2.3
Alcohol intake frequency.	1.5	3.4	6.9	2.5	1.7	1.1	1.5	0.3	2.2	2.6
Number of self-reported non-cancer illnesses	1.5	2.6	5.6	0.3	2.1	2.4	1.3	1.8	1.5	1.0
Basal cell carcinoma (self-reported)	1.5	1.8	5.4	0.0	-1.2	-0.4	-1.9	-2.3	-1.4	0.1
HDL Cholesterol	1.4	2.3	4.4	0.7	2.1	1.7	1.5	2.1	1.3	0.4
Type 2 Diabetes (T2D) (2012)	1.4	1.6	5.4	-0.2	-0.5	-2.2	-0.7	-2.3	-0.8	0.2
Chronotype (morning person)	1.4	3.2	8.2	1.3	1.5	-0.5	2.9	2.4	2.0	-0.1
Diabetes (mother)	1.4	1.8	3.8	-1.6	-1.3	-1.6	-0.3	-0.8	-1.1	-1.9
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.6	-1.4	-2.1	-2.6	-0.4	-2.0	-1.1	-1.6
Medication: Gliclazide	1.4	1.6	4.0	-2.0	-1.7	-1.3	-0.2	-0.2	-0.7	-1.4
Alcohol intake versus 10 years previously	1.3	2.0	3.9	1.6	1.5	1.2	1.1	0.3	1.6	2.0
Exposure to tobacco smoke outside home	1.3	1.8	2.7	0.5	1.7	1.5	1.5	1.5	1.5	0.5
Medication: Omeprazole	1.3	1.6	3.6	-1.1	-1.6	-1.7	-0.3	-1.9	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	5.9	2.4	1.5	0.3	1.9	0.6	2.0	1.5
Diabetes diagnosed by doctor	1.3	2.1	5.0	-1.7	-1.9	-2.2	-0.4	-1.6	-0.7	-0.5
Medication: Paracetamol	1.3	2.0	5.7	1.5	1.4	2.4	-0.6	0.6	0.3	1.8
Alcohol drinker status: Never	1.3	1.5	3.3	1.7	1.3	0.6	0.8	0.4	1.2	1.8
Bipolar Disorder (2018)	1.2	2.0	3.3	1.2	1.8	0.4	1.8	1.6	1.6	0.8
Alzheimer’s Disease (in mother)	1.2	1.4	4.5	2.1	1.0	0.2	1.0	0.9	1.1	0.9
Major Depression (MDD)	1.2	1.5	4.3	1.1	0.8	-1.4	2.1	0.7	1.4	-0.1
Mouth/teeth dental problems	1.2	1.8	6.7	0.6	-1.1	-1.6	-1.1	-2.6	-1.0	0.1
Shortness of breath walking on level ground	1.2	1.5	3.5	1.3	0.9	1.1	0.7	0.9	1.4	1.9
Supplements: Vitamin C	1.2	1.5	5.0	0.7	-0.1	-1.5	2.2	0.2	1.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.2	1.6	0.9	0.5	0.8	0.0	1.3	1.8
Irritable Bowel Disease (IBD)	1.1	2.7	9.3	-0.4	1.8	1.7	1.5	3.0	1.0	-0.3
Lung FVC	1.1	5.7	12.9	-3.6	-2.1	0.2	-2.6	-1.0	-2.8	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.2	-2.0	-1.2	0.7	-1.8	-1.1	-1.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	8.2	-0.7	-1.7	-2.9	0.1	-1.7	-0.9	-1.8
Lung cancer (father)	1.1	1.3	4.5	1.3	0.7	1.1	-0.1	-0.7	0.8	2.1
Tense / ‘highly strung’	1.1	1.8	5.6	-1.0	-1.0	0.4	-2.4	-1.4	-1.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	6.9	-2.6	-1.9	-0.6	-1.1	-0.3	-1.3	-1.5
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.8	-1.0	-1.0	0.8	-1.9	-1.0	-1.5	-0.5
Vascular/heart problems diagnosed by doctor	1.1	3.0	4.8	-1.3	-2.2	-1.8	-1.5	-1.4	-1.9	-1.9
Pack years of smoking	1.1	1.7	3.0	-1.1	-1.7	-1.2	-0.4	-1.6	-0.9	-1.7
Breast Cancer	1.0	2.5	3.9	-1.7	-1.8	-1.4	-1.1	-1.2	-1.7	-2.0
Prostate Cancer	1.0	1.4	2.7	1.6	0.9	1.1	0.5	1.2	1.1	1.5
Systolic blood pressure, automated reading	1.0	2.8	7.5	-1.6	-1.2	0.3	-2.7	-1.1	-2.4	-0.9
Medication: Atenolol	1.0	1.3	2.8	1.1	1.1	1.0	0.9	0.4	1.4	1.7
Neck or shoulder pain in last month	1.0	1.5	4.0	-1.3	-0.5	1.6	-2.0	-0.4	-1.3	-0.1
Hearing aid user	1.0	1.1	2.6	-0.4	-0.2	1.0	-1.6	-1.5	-0.6	1.1
Unable to work because of sickness or disability	1.0	1.3	4.9	0.8	-0.3	0.1	-1.2	-2.2	-0.4	1.3
Heart disease (siblings)	1.0	1.2	3.6	0.5	0.7	-0.4	1.9	1.4	1.4	-0.1
Depressed Affect (Nagel 2018)	0.9	1.9	5.4	0.6	1.4	2.3	-0.2	2.2	0.3	0.9
Depression (Nagel 2018)	0.9	1.3	2.6	-1.4	0.0	1.6	-1.0	1.1	-0.9	-1.1
Worry (Nagel 2018)	0.9	1.9	5.7	-1.3	-0.1	1.7	-2.4	0.2	-1.8	-0.2
Average weekly spirits intake	0.9	1.1	1.9	-0.8	-1.1	-1.4	-0.7	-1.1	-1.1	-1.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.4	-0.7	-1.2	-1.9	-0.4	-0.9	-0.6	-0.3
Supplements: Zinc	0.9	1.0	1.9	1.4	0.4	-1.2	0.9	-0.7	1.0	1.2
Relative age voice broke	0.9	1.3	2.7	-0.7	-1.2	-1.1	-1.3	-0.5	-1.7	-1.1
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.0	1.4	0.8	0.0	0.9	-0.0	1.2	1.4
Hair/balding pattern: Pattern 2	0.9	1.1	3.0	1.3	1.2	1.7	-0.1	0.7	0.4	1.2
Asthma	0.9	1.7	4.5	0.7	1.6	-0.6	2.1	1.5	1.3	-0.2
Birth weight of first child	0.9	1.6	4.1	-1.7	0.1	-0.1	1.5	2.0	0.6	-1.3
Age at first live birth	0.9	1.7	3.7	-1.6	-0.5	-0.2	-1.3	0.2	-1.9	-1.9
Suffer from ‘nerves’	0.9	1.5	4.4	-0.6	0.3	2.1	-2.0	0.1	-1.1	0.5
Had major operations	0.9	1.0	3.6	-1.9	-1.1	-0.9	0.4	0.1	-0.1	-1.1
Illnesses of siblings: Diabetes	0.9	1.1	3.5	0.4	-0.5	-0.4	-1.5	-1.9	-1.2	-0.4
Mood swings	0.9	1.7	5.7	0.2	1.4	2.4	0.2	1.5	0.8	1.0
Osteoporosis (self-reported)	0.9	1.1	2.8	-1.0	-0.8	0.2	-1.7	-0.8	-1.5	-0.8
Ever smoked	0.9	1.5	3.8	0.9	1.1	1.9	-0.1	-0.2	0.9	2.0
Age started oral contraceptive pill	0.9	1.1	2.3	-1.0	0.2	0.7	-0.9	1.3	-1.3	-1.5
Triglycerides	0.8	1.3	2.1	-0.8	-1.2	-0.9	-1.2	-0.9	-1.4	-1.4
Past tobacco smoking	0.8	1.6	3.1	-0.9	-1.3	-1.8	-0.6	-0.7	-1.3	-1.7
Alcohol usually taken with meals	0.8	1.3	2.9	1.0	1.1	1.7	-0.3	0.8	0.5	1.7
Financial difficulties in last 2 years	0.8	1.1	2.7	0.4	0.9	1.5	0.4	0.5	1.1	1.6
Hair/balding pattern: Pattern 3	0.8	1.2	3.2	-1.8	-1.0	-1.1	0.1	0.6	-0.6	-1.6
Number of live births	0.8	1.1	3.9	-0.6	-0.2	1.2	-2.0	-0.5	-1.0	0.8
Medication: Cholesterol lowering	0.8	1.2	2.9	0.1	1.2	1.3	1.0	1.7	1.0	0.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.2	0.5	0.4	-0.8	1.8	0.1	1.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	1.3	1.4	0.3	1.1	1.0	0.9	0.2
Comparative height size at age 10	0.8	4.3	9.1	1.7	2.2	1.7	2.4	3.0	2.1	0.7
Ever had bowel cancer screening	0.8	1.0	2.2	1.5	0.9	1.1	-0.4	0.7	0.2	1.4
Asthma (self-reported)	0.8	1.7	4.5	0.6	1.6	-0.5	2.1	1.4	1.4	-0.1
Bipolar Disorder (2011)	0.7	0.6	1.4	1.1	1.2	-0.4	0.9	0.5	0.6	0.5
Coronary Artery Disease (CAD)	0.7	0.8	1.6	-1.2	-0.7	-1.2	0.7	0.5	-0.1	-1.3
Blood Eosinophil Count	0.7	5.7	15.0	-2.3	-1.3	-3.1	2.4	1.5	0.0	-3.9
Pack years adult smoking proportion	0.7	1.1	2.0	-0.8	-1.4	-0.9	-0.2	-1.4	-0.6	-1.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	2.7	-1.2	0.6	0.5	0.9	1.6	0.5	-0.6
High blood pressure	0.7	2.0	2.9	0.7	1.7	1.6	1.3	1.4	1.6	1.3
Chronic bronchitis/emphysema (father)	0.7	0.8	1.2	0.9	1.1	1.1	0.6	0.9	0.8	0.8
Qualifications: None of the above	0.7	1.6	4.9	0.4	1.4	2.2	0.5	1.1	1.1	1.2
Noisy workplace	0.7	0.8	2.2	0.0	-1.2	-0.0	-1.5	-1.2	-1.0	-0.1
Prospective memory result	0.7	0.9	2.8	-1.7	-1.3	-0.6	-0.6	-0.9	-0.4	-0.0
Loud music exposure frequency	0.7	0.7	2.2	1.1	0.4	0.8	-0.6	-0.6	0.3	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.7	-1.6	-0.8	-0.1	-0.3	0.0	-0.7	-1.6
Medication: Allopurinol	0.7	0.9	2.7	1.6	0.9	0.7	0.4	0.0	0.8	1.3
Medication for cholesterol	0.7	1.0	2.5	-0.7	-1.6	-1.1	-0.9	-0.8	-0.9	-0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.2	0.6	-0.0	-1.4	1.2	0.6	0.1	-1.5
Number of operations (self-reported)	0.7	1.0	4.7	-2.2	-0.6	0.1	0.6	0.9	0.2	-1.0
Average weekly beer plus cider intake	0.7	1.0	3.5	0.2	-1.2	-1.9	0.5	-1.3	0.1	-0.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.5	0.5	0.6	-0.4	1.6	1.2	1.0	-0.1
Cholesterol lowering medication	0.7	1.0	2.7	-1.1	-0.4	-1.0	-0.4	-0.7	-1.2	-1.6
Crohns Disease (2012)	0.6	1.0	3.9	-0.3	0.5	0.4	0.6	2.0	-0.1	-1.5
Schizophrenia (2014)	0.6	1.2	2.9	-1.0	-1.3	-1.7	0.9	-0.2	-0.1	-1.5
Medication: Co-codamol	0.6	0.6	1.4	-0.0	0.6	0.5	1.1	0.9	1.2	0.8
Diabetes (father)	0.6	0.7	1.8	0.6	-0.9	-1.4	0.1	-1.0	0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	0.0	0.4	1.4	-1.2	0.0	-0.5	0.9
Time employed in main current job	0.6	0.7	3.6	1.9	0.9	-0.1	0.1	-0.1	0.3	0.7
Peak expiratory flow (PEF)	0.6	1.5	2.0	-1.4	-1.4	-1.0	-1.2	-0.8	-1.3	-1.2
Glaucoma (self-reported)	0.6	0.7	1.9	-1.0	0.4	1.3	0.1	1.4	0.2	-0.2
Medication: Amlodipine	0.6	0.8	1.6	1.2	0.5	-0.6	1.3	0.1	1.2	0.9
Pulse wave peak to peak time	0.6	0.7	1.3	0.6	1.1	1.1	0.3	0.9	0.7	0.9
Eye problems/disorders: None of the above	0.6	0.7	1.3	-0.5	-0.8	-0.4	-1.0	-0.9	-1.1	-0.9
Medication: Seretide 50 evohaler	0.6	0.7	1.9	0.7	0.4	-0.5	1.4	0.3	1.2	0.6
Age at last live birth	0.6	0.8	1.8	-0.3	0.8	1.3	-1.2	0.7	-1.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.7	1.3	0.9	0.2	0.9	0.6	1.0	0.4
Mineral and other dietary supplements	0.6	0.8	2.4	-0.7	-0.3	1.2	-1.6	-0.4	-0.9	0.2
Ever taken oral contraceptive pill	0.6	0.6	1.2	0.8	0.5	0.6	0.9	0.6	1.1	0.9
Commuting to job workplace: Public transport	0.6	0.7	1.5	-0.9	-1.2	-1.0	-0.4	-0.9	-0.5	-0.6
Risk taking	0.6	0.9	2.4	0.1	-0.8	0.0	-1.5	-1.5	-0.8	0.6
Fractured/broken bones in last 5 years	0.6	0.7	1.9	0.0	-0.6	-0.5	-1.2	-1.4	-1.1	-0.4
Neuroticism (Nagel 2018)	0.5	1.3	3.3	-0.4	0.4	1.8	-1.8	0.8	-1.2	0.2
Fasting Glucose	0.5	0.6	1.4	0.8	-0.7	0.1	-0.9	-1.2	-0.2	0.8
Heel T-Score	0.5	4.3	17.1	-0.7	-0.6	-4.1	1.8	-0.7	-0.3	-2.9
Average weekly fortified wine intake	0.5	0.6	1.8	-0.8	-0.8	0.3	-1.4	-0.2	-0.9	-0.2
High blood pressure (mother)	0.5	0.7	1.4	-1.2	-0.4	0.9	-0.5	0.8	-0.6	-1.1
Number of incorrect matches in round	0.5	0.8	2.1	1.1	1.5	0.1	0.8	0.8	0.8	0.7
Forced vital capacity (FVC)	0.5	2.0	5.9	-2.2	-1.4	-0.4	-0.5	0.0	-1.2	-2.4
Fluid intelligence score	0.5	1.0	3.3	-1.8	-0.6	-0.2	1.1	1.2	0.5	-0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.5	0.3	0.8	0.6	0.9	1.2	1.2	0.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.7	0.0	0.1	0.1	1.2	1.3	1.1	0.1
Number of children fathered	0.5	0.6	1.1	0.2	-1.0	-0.4	-0.9	-1.0	-0.7	-0.5
Hypertension (Self-reported)	0.5	1.4	2.2	0.4	1.5	1.5	1.1	1.3	1.3	0.9
Smoking status: Previous	0.5	0.8	1.7	0.7	0.8	0.7	0.9	0.3	1.2	1.3
Long-standing illness, disability or infirmity	0.5	0.7	2.6	0.5	-0.5	-0.5	-0.6	-1.6	-0.0	1.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	-1.1	-0.2	0.2	-1.0	-0.4	-1.0	-0.7
Mother’s age at death	0.5	0.6	1.7	-0.2	-0.7	-1.2	0.5	0.3	-0.3	-1.3
Schizophrenia (2018)	0.4	0.9	1.9	-1.0	-1.4	-1.2	-0.4	-0.9	-0.6	-0.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.5	-1.5	-0.6	0.1	0.7	1.6	0.2	-0.9
Ovarian Cancer	0.4	0.5	1.7	-0.6	-0.5	-0.9	-0.2	-0.3	-0.8	-1.3
Ulcerative Colitis	0.4	0.6	2.3	-0.7	-0.8	-1.5	0.7	-0.0	0.1	-0.5
Blood Red Count	0.4	3.8	9.7	-0.3	2.1	2.2	2.1	3.1	1.7	-0.6
Height	0.4	7.0	18.3	1.1	1.8	1.1	4.3	3.7	3.3	-0.1
Smoking Status	0.4	1.0	2.0	0.8	1.1	0.7	1.1	0.1	1.4	1.4
Severe depression (siblings)	0.4	0.4	1.6	0.6	-0.3	-1.3	0.2	-0.8	-0.1	0.0
Hand grip strength (right)	0.4	1.1	4.0	0.9	-1.2	-2.0	-0.2	-1.0	-0.5	-0.5
Age when periods started (menarche)	0.4	1.0	3.8	0.4	0.6	1.4	-0.0	-0.0	0.9	1.9
Serious illness, injury or assault to yourself	0.4	0.4	1.4	0.0	-0.6	-0.4	-0.2	-1.2	0.3	1.0
Stomach or abdominal pain in last month	0.4	0.4	1.3	0.2	-0.9	-1.2	-0.3	-0.9	-0.2	0.3
Nervous feelings	0.4	0.7	1.9	0.6	1.0	1.4	-1.0	0.5	-0.5	0.7
Allergy	0.4	0.9	3.3	1.0	0.7	1.8	-0.8	0.3	-0.1	0.9
Trunk fat-free mass	0.4	2.3	6.9	1.5	0.7	-0.9	2.6	0.4	2.1	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	-0.6	-0.9	-0.9	-0.1	-0.6	-0.5	-0.8
Trunk predicted mass	0.4	2.3	7.2	1.6	0.8	-0.8	2.7	0.5	2.2	0.8
Length of working week for main job	0.4	0.5	1.3	-0.9	-0.8	-0.4	-0.2	-0.0	-0.5	-1.2
Exposure to tobacco smoke at home	0.4	0.4	2.0	-1.4	-0.7	0.5	-0.3	-0.2	-0.2	-0.3
Breastfed as a baby	0.4	0.5	1.6	-0.5	0.8	0.6	0.5	1.2	0.2	-0.3
Birth weight	0.4	0.9	1.6	-1.2	-1.2	-0.4	-0.9	-1.3	-0.8	-0.0
Worry too long after embarrassment	0.4	0.7	2.2	0.2	0.1	1.4	-0.5	0.3	0.3	1.5
Qualifications: College or University degree	0.4	1.2	5.6	-0.2	-0.8	-2.4	0.2	-0.7	-0.6	-1.1
Mean time to correctly identify matches	0.4	0.8	1.9	-0.9	-0.8	-0.6	-0.6	-0.4	-1.0	-1.4
Pulse rate, automated reading	0.4	1.4	3.0	0.0	-0.5	-0.5	-1.7	-1.7	-1.7	-0.7
Overall health rating	0.4	0.8	2.3	1.1	0.3	0.8	-0.9	-0.8	-0.1	1.5
Whole body fat-free mass	0.4	2.1	5.7	1.6	0.7	-0.5	2.4	0.2	2.1	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-0.3	-0.9	-0.4	-1.1	-0.7	-0.9	-0.3
Loneliness, isolation	0.4	0.6	1.2	1.0	0.7	0.8	0.0	0.7	0.5	1.1
Osteoarthritis (self-reported)	0.4	0.5	1.6	0.8	0.5	0.8	-0.0	0.1	0.6	1.3
Whole body water mass	0.4	2.1	5.3	1.7	0.7	-0.5	2.3	0.1	2.1	1.1
Wears glasses or contact lenses	0.4	0.4	0.9	0.5	0.7	0.9	-0.8	-0.0	-0.2	0.8
Diastolic blood pressure, automated reading	0.4	1.1	4.3	1.0	0.5	2.1	-0.6	-0.2	0.2	1.3
Commuting to job workplace: Cycle	0.4	0.5	1.5	-1.2	-0.3	-0.5	0.5	0.8	0.1	-0.8
Myopia	0.4	0.5	1.8	0.5	0.5	-0.7	1.3	0.6	0.8	-0.3
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.3	-1.8	-0.6	-0.6	0.8	1.0	-0.0	-1.2
Mean Putamen Volume	0.3	0.4	0.8	-0.8	0.1	0.9	-0.9	0.0	-0.4	0.3
HbA1C	0.3	0.4	1.4	0.2	-0.8	-0.6	-0.3	-1.2	-0.2	0.0
Systolic Blood Pressure	0.3	1.4	5.0	-0.4	0.1	0.7	-2.2	-0.8	-1.9	-0.5
Respiratory disease	0.3	0.7	3.4	-0.0	-0.2	-1.9	0.5	-0.3	-0.4	-1.1
Neuroticism	0.3	0.7	2.7	-0.5	0.4	1.7	-0.8	0.7	-0.2	0.6
Hair Pigment	0.3	8.2	10.2	-3.1	-3.1	-3.2	-2.6	-2.6	-2.9	-2.5
Sensitivity / hurt feelings	0.3	0.5	1.6	1.3	0.5	-0.9	0.7	-0.0	0.3	-0.1
Leg fat-free mass (left)	0.3	1.8	3.7	1.5	0.8	0.2	1.8	0.0	1.9	1.6
Maternal smoking around birth	0.3	0.4	1.0	-1.0	-0.6	-0.3	-0.5	0.2	-0.6	-0.9
Qualifications: CSEs or equivalent	0.3	0.4	1.3	1.1	-0.2	-0.2	0.5	-0.7	0.7	0.7
Impedance of leg (left)	0.3	1.4	4.7	-2.2	-0.9	0.1	-0.7	0.6	-1.0	-1.6
Leg predicted mass (left)	0.3	1.8	3.7	1.6	0.8	0.2	1.8	0.0	1.9	1.5
Waist circumference	0.3	1.0	2.8	1.0	-0.2	0.1	0.7	-1.1	1.2	1.7
Pain all over the body in last month	0.3	0.3	1.6	0.2	-0.2	-0.1	-0.6	-1.2	-0.6	-0.3
Neuroticism score	0.3	0.7	1.6	-1.2	-0.2	1.3	-1.1	0.2	-0.5	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.6	-1.5	-1.3	-0.6	-0.5	-0.2	-0.9	-1.6
Pulse rate	0.3	0.4	1.7	0.2	-0.2	-0.6	-0.7	-1.3	-0.6	0.2
Illnesses of mother	0.3	0.4	1.1	0.8	0.9	0.0	0.1	-0.1	0.4	1.0
Arm fat mass (right)	0.3	1.2	4.5	0.9	0.2	0.9	0.2	-0.9	1.1	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.3	0.5	0.5	1.0	0.3	0.5	0.8	1.1
Pulse wave reflection index	0.3	0.3	0.7	0.4	-0.4	-0.8	0.7	-0.4	0.2	-0.8
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.7	-0.9	-0.8	0.3	-0.5	0.2	-0.1
Gout (self-reported)	0.3	0.4	1.1	1.0	0.7	0.5	-0.2	-0.1	0.2	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	-0.8	-0.7	-0.4	0.4	0.2	-0.2	-1.2
Forced vital capacity (FVC), Best measure	0.3	1.0	2.9	-1.7	-1.2	-0.2	-0.0	0.1	-0.5	-1.6
Arm fat-free mass (right)	0.3	1.6	3.7	1.6	0.5	-0.3	1.9	-0.1	1.8	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.2	-0.3	-1.1	-0.4	-0.5	-0.9	-0.3	0.0
Migraine (self-reported)	0.3	0.3	1.0	1.0	0.8	0.8	0.0	0.0	0.2	0.2
Arm predicted mass (right)	0.3	1.5	3.8	1.6	0.5	-0.5	1.9	-0.2	1.7	1.0
Number of full sisters	0.3	0.3	1.1	-0.3	-0.5	0.1	-0.7	-1.0	-0.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	0.8	0.9	0.9	-0.1	0.2	0.2	0.7
Leg fat-free mass (right)	0.3	1.5	3.2	1.4	0.4	-0.2	1.8	-0.1	1.8	1.3
Commuting to job workplace: Walk	0.3	0.3	1.3	0.3	0.4	1.1	0.0	-0.4	0.3	0.6
Back pain experienced in last month	0.3	0.4	2.0	0.7	0.5	0.2	-0.2	-0.2	0.4	1.4
Breast cancer (self-reported)	0.3	0.3	1.0	-1.0	-0.2	0.4	-0.8	-0.2	-0.6	-0.3
Smoking status: Current	0.3	0.5	1.8	0.5	0.9	1.3	-0.0	0.2	0.5	0.7
Guilty feelings	0.3	0.4	1.2	-0.9	-0.2	0.7	-1.1	-0.2	-0.6	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	-0.9	-0.3	0.7	-0.9	-0.1	-0.6	-0.1
High cholesterol (Self-reported)	0.3	0.5	2.1	-0.7	0.0	-0.0	-0.4	0.1	-0.9	-1.4
Medication: Lisinopril	0.3	0.3	0.6	0.3	0.5	0.5	0.8	0.2	0.8	0.7
Medication: Atorvastatin	0.3	0.4	1.3	-0.7	0.1	-0.1	1.1	0.6	0.8	-0.4
Basal metabolic rate	0.3	1.9	4.5	1.6	0.6	-0.2	2.1	-0.0	2.0	1.3
Arm fat-free mass (left)	0.3	1.7	4.7	1.4	0.5	-0.4	2.2	-0.0	1.9	1.1
Supplements: Calcium	0.3	0.3	0.7	-0.0	-0.2	-0.5	0.9	-0.4	0.8	0.4
Alcohol drinker status: Previous	0.3	0.3	1.7	0.2	-0.2	-0.4	-0.1	-1.3	-0.2	-0.3
Arm predicted mass (left)	0.3	1.7	4.6	1.3	0.5	-0.2	2.1	0.0	2.0	1.2
Ulcerative Colitis (UC)	0.2	0.4	1.4	-0.1	0.7	0.5	0.8	1.2	0.5	0.1
Reaction Time	0.2	0.4	1.2	-0.0	-0.4	-0.6	-0.3	-0.3	-0.6	-1.1
Rheumatoid Arthritis	0.2	0.3	0.7	-0.7	-0.4	0.5	-0.3	0.3	-0.5	-0.8
BMI	0.2	1.0	3.9	1.0	-0.2	-0.4	-0.3	-2.0	0.1	1.2
Waist Hip Ratio (WHR)	0.2	1.1	3.1	1.4	0.2	-0.4	1.8	0.1	1.4	0.3
Lung FEV1/FVC ratio	0.2	0.9	3.2	0.3	-0.8	-1.8	-0.4	-1.4	-0.2	0.2
Tanning	0.2	2.3	4.5	2.1	1.1	0.2	2.0	1.2	1.9	1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	-0.8	0.3	1.1	-0.0	0.4	0.1	0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.1	-0.5	-0.5	-1.1	0.0	-0.5	-0.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.0	-1.0	0.0	0.0	-0.1	0.6	-0.4	-0.7
Angina	0.2	0.2	0.9	0.1	-0.0	-0.6	-0.3	-1.0	-0.1	0.6
Impedance of leg (right)	0.2	1.1	3.7	-1.9	-0.4	0.6	-0.6	0.9	-0.9	-1.3
Trunk fat percentage	0.2	0.9	3.6	-0.0	0.2	1.9	-0.4	-0.2	0.5	1.6
Fed-up feelings	0.2	0.4	2.0	-0.4	0.3	1.4	-0.3	0.1	0.1	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.7	-0.3	0.5	0.7	0.2	0.6	-0.3
Body mass index (BMI)	0.2	0.9	2.7	0.7	-0.3	0.1	-0.1	-1.6	0.6	1.6
Trunk fat mass	0.2	1.0	3.2	0.6	0.4	1.5	0.2	-0.3	1.0	1.8
Heart attack	0.2	0.3	0.7	0.9	0.5	0.2	0.2	-0.1	0.5	0.7
Medication: Simvastatin	0.2	0.3	0.7	-0.2	0.6	-0.1	0.4	0.8	-0.1	-0.8
Illnesses of siblings	0.2	0.3	0.6	-0.4	0.2	0.3	0.7	0.6	0.8	0.6
Weight	0.2	1.0	2.7	1.0	0.1	0.3	1.0	-0.6	1.4	1.6
Impedance of arm (right)	0.2	0.9	2.1	-1.5	0.2	1.0	-0.4	1.5	-0.3	-0.6
Arm fat percentage (right)	0.2	0.9	3.3	0.3	0.0	1.1	-0.5	-1.0	0.5	1.8
Hip circumference	0.2	0.8	2.4	0.8	-0.1	0.4	0.0	-1.3	0.7	1.6
Worrier / anxious feelings	0.2	0.4	1.0	0.3	0.6	1.0	-0.4	0.3	0.1	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.9	1.4	0.1	-0.7	-0.0	-0.2	0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.2	-0.2	-0.8	0.5	-0.1	-0.0	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.5	-0.4	0.2	1.2	-0.2	0.4	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	-1.1	-1.1	-0.1	-0.2	-0.0	-0.4	-1.0
Impedance of arm (left)	0.2	1.0	2.2	-1.3	0.2	1.5	-1.0	1.1	-0.8	-0.6
Standing height	0.2	2.0	5.7	0.4	0.8	0.2	2.4	2.0	1.8	0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.6	-0.1	-0.1	-0.2	-0.9	-1.3	-0.9	-0.2
High blood pressure (siblings)	0.2	0.3	0.6	-0.2	-0.6	-0.2	-0.7	-0.3	-0.8	-0.8
Body fat percentage	0.2	0.8	2.4	0.1	0.2	1.6	-0.3	-0.5	0.5	1.5
Leg fat percentage (right)	0.2	0.6	1.9	-0.2	-0.4	0.6	-0.9	-1.4	-0.3	0.8
Comparative body size at age 10	0.2	0.5	2.0	-0.2	-0.6	-0.2	-0.3	-0.2	-0.8	-1.4
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	-0.4	-0.6	-1.2	0.1	-0.9	0.0	0.3
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.7	-0.1	-0.6	-0.1	-0.6	-0.1	0.1
Angina (self-reported)	0.2	0.2	0.6	0.2	0.1	-0.7	-0.2	-0.8	-0.1	0.5
Whole body fat mass	0.2	0.8	3.0	0.4	0.2	1.1	0.3	-0.4	1.0	1.7
Leg fat mass (right)	0.2	0.7	2.6	0.6	0.1	0.6	0.2	-1.0	0.8	1.6
Chest pain or discomfort	0.2	0.3	1.1	1.0	0.1	-0.3	-0.1	-0.6	-0.0	0.5
Family relationship satisfaction	0.2	0.3	0.9	-0.6	-0.8	-1.0	-0.0	-0.2	-0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	-0.6	-0.2	0.3	-0.8	0.6	-0.6	-0.1
Arm fat percentage (left)	0.2	1.0	3.2	0.5	0.1	1.3	-0.7	-1.0	0.3	1.8
Friendships satisfaction	0.2	0.2	0.8	0.3	-0.1	-0.2	0.0	0.7	-0.4	-0.9
Leg predicted mass (right)	0.2	1.3	3.0	1.3	0.4	-0.2	1.7	-0.1	1.7	1.2
Arm fat mass (left)	0.2	1.0	3.4	0.8	0.1	0.9	0.1	-1.0	0.8	1.9
Miserableness	0.2	0.4	1.4	0.1	0.3	1.2	-0.4	-0.1	0.2	1.0
Leg fat percentage (left)	0.2	0.6	2.2	-0.2	-0.6	0.3	-0.8	-1.5	-0.3	0.7
Pain experienced in last month	0.2	0.4	1.6	0.2	-0.1	-1.3	0.3	0.2	-0.3	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	-0.2	-0.7	-0.8	0.4	-0.6	0.4	0.2
Impedance of whole body	0.2	1.1	2.4	-1.5	-0.1	1.4	-0.9	1.1	-0.8	-0.7
Leg fat mass (left)	0.2	0.8	2.9	0.7	0.1	0.5	0.2	-1.0	0.9	1.7
Bipolar Disorder or Schizophrenia	0.1	0.2	0.7	-0.0	0.1	-0.7	0.8	0.3	0.5	0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.5	0.2	-0.4	-0.1	-0.4	-0.7	-0.1	0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	1.0	1.0	0.1	-0.2	-0.2	-0.2	-0.0	0.5
Age at First Birth	0.1	0.2	0.7	-0.1	0.0	0.3	0.2	-0.1	0.6	0.8
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	-0.5	0.2	-0.3	0.3	-0.1	0.1
Lupus	0.1	0.2	0.4	0.6	0.6	0.3	0.5	0.6	0.3	0.1
Cardiovascular Disease	0.1	0.4	1.2	0.6	1.0	1.1	-0.4	-0.1	-0.0	0.3
Hypothyroidism (self reported)	0.1	0.3	0.9	0.3	0.3	0.1	-0.6	-1.0	-0.4	0.4
Hand grip strength (left)	0.1	0.4	1.1	1.0	-0.7	-0.6	-0.4	-0.7	-0.2	0.0
Current tobacco smoking	0.1	0.2	0.7	0.3	0.6	0.8	0.0	-0.0	0.4	0.4
Taking other prescription medications	0.1	0.2	0.5	-0.2	0.1	0.4	0.6	-0.0	0.7	0.3
Supplements: Glucosamine	0.1	0.1	0.4	0.6	0.5	-0.2	0.1	0.2	-0.0	0.2
Medication: Levothyroxine sodium	0.1	0.2	0.6	-0.2	0.5	0.8	0.1	-0.4	0.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.7	-0.2	0.2	0.4	0.2	0.8	-0.0	-0.5
Medication: Ramipril	0.1	0.2	0.8	0.1	0.3	0.3	-0.3	-0.2	0.1	0.9
Father’s age at death	0.1	0.1	0.4	0.6	0.4	0.3	0.0	0.3	0.2	0.5
Happiness	0.1	0.1	0.3	-0.1	-0.1	0.4	-0.3	0.5	-0.4	-0.3
Depression (self-reported)	0.1	0.1	0.4	-0.0	0.1	-0.0	0.6	0.3	0.4	-0.4
Medication: Lansoprazole	0.1	0.1	0.4	-0.6	-0.1	-0.1	-0.1	0.2	-0.2	-0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	0.9	0.1	-0.6	0.4	-0.8	0.3	0.1
Headache pain in last month	0.1	0.2	0.6	0.1	0.0	0.4	-0.5	-0.6	0.1	0.7
Health satisfaction	0.1	0.1	0.5	-0.7	-0.1	0.3	0.3	0.3	0.3	0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.2	-0.6	-0.3	0.0	-0.6	0.2	0.5
Heart disease (mother)	0.1	0.1	0.3	-0.4	-0.5	-0.3	0.1	-0.2	-0.2	-0.5
Leg pain on walking	0.1	0.1	0.2	-0.4	-0.3	-0.0	-0.4	-0.1	-0.0	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.6	-0.8	-0.1	0.2	-0.5	0.1	-0.5	-0.4
Knee pain experienced in last month	0.1	0.1	0.2	0.2	0.0	0.2	0.2	-0.5	0.4	0.3
Illnesses of father: Heart disease	0.1	0.1	0.5	0.2	-0.2	-0.4	-0.0	-0.7	0.1	0.3
Qualifications: nursing, teaching	0.1	0.2	0.5	0.7	0.3	-0.2	0.6	0.4	0.5	0.3
Medication: Blood pressure	0.1	0.2	0.9	-0.6	0.1	1.0	-0.2	-0.1	-0.0	0.1
Ever depressed for a whole week	0.1	0.1	0.4	-0.1	-0.3	-0.4	0.1	0.7	0.1	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.6	0.4	0.1	0.1	-0.2	0.3	0.4
Blood White Count	0.0	0.1	0.2	0.2	0.3	0.5	-0.2	-0.0	0.1	0.4
Sitting height	0.0	0.3	0.7	-0.6	0.1	0.8	-0.7	0.4	-0.6	-0.2

Hub : Genes

ZNF487

Models

Trait associations