Hub : Genes

ZNF667-AS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1555 0.0475 5.9e-04 0.085 NA 0.024 NA 0.060 3.4e-07 NA 5.2e-03 NA 1.9e-05
2 GTEx Brain Caudate basal ganglia 0.4280 0.1040 1.4e-04 0.221 NA 0.106 NA 0.174 5.3e-07 NA 5.8e-04 NA 1.0e-05
3 GTEx Brain Cerebellar Hemisphere 0.5710 0.1040 3.9e-06 0.415 NA 0.213 NA 0.324 7.6e-12 NA 3.6e-06 NA 4.3e-09
4 GTEx Brain Cerebellum 0.4060 0.0980 2.4e-04 0.278 NA 0.101 NA 0.264 7.7e-09 NA 6.6e-04 NA 2.0e-08
5 GTEx Cells Transformed fibroblasts 0.1700 0.0440 1.3e-04 0.098 NA 0.096 NA 0.091 8.2e-08 NA 1.2e-07 NA 2.6e-07
6 GTEx Heart Atrial Appendage 0.3540 0.0760 6.0e-06 0.155 NA 0.069 NA 0.144 1.8e-07 NA 4.9e-04 NA 5.4e-07
7 GTEx Muscle Skeletal 0.0679 0.0231 1.2e-03 0.072 NA 0.068 NA 0.076 1.4e-07 NA 3.3e-07 NA 6.2e-08
8 GTEx Skin Sun Exposed Lower leg 0.1850 0.0510 7.2e-05 0.005 NA 0.027 NA 0.027 1.2e-01 NA 2.5e-03 NA 2.5e-03
9 GTEx Testis 0.5040 0.0670 1.4e-11 0.580 NA 0.567 NA 0.579 5.3e-31 NA 5.6e-30 NA 6.4e-31
10 GTEx Whole Blood 0.1030 0.0360 2.0e-03 0.029 NA 0.044 NA 0.029 9.5e-04 NA 6.8e-05 NA 1.0e-03
11 METSIM Adipose 0.0743 0.0220 1.3e-05 0.023 0.047 0.065 0.051 0.051 1.8e-04 1.5e-07 4.6e-10 3.8e-08 3.7e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.9 1.5 3.7 -1.4 0.1 -1.5 -1.4 1.1 1.3 -0.0 -1.3 1.4 -1.9 -0.1
Bipolar Disorder or Schizophrenia 0.9 2.2 5.1 -0.8 2.2 -0.7 -1.2 0.2 0.8 -2.0 -2.3 0.9 -2.1 -1.3
Depressed Affect (Nagel 2018) 0.7 1.6 2.8 -1.6 -1.2 -1.3 -1.6 1.6 1.7 1.1 -0.6 1.5 -0.3 0.1
Depression (Nagel 2018) 0.3 0.5 0.9 -0.7 0.3 -0.7 -0.6 0.9 1.0 -0.2 -0.9 0.8 -0.7 -0.2
Intelligence (Savage-Jansen 2018) 0.8 2.3 5.2 -1.6 -0.8 -1.6 -1.7 2.3 1.9 1.6 0.5 1.6 -1.3 1.2
Neuroticism (Nagel 2018) 0.3 0.7 2.5 -0.8 0.2 -0.5 -1.0 -0.0 0.6 -0.5 -1.6 0.8 -0.7 -1.2
Schizophrenia (2018) 1.0 2.0 7.6 0.1 2.8 0.4 -0.3 -0.7 -0.0 -2.5 -1.9 0.0 -1.2 -1.5
Schizophrenia vs Biploar Disorder 1.8 2.3 4.2 1.8 1.8 2.0 1.7 -1.8 -1.8 -1.2 0.5 -1.7 1.1 -0.1
Worry (Nagel 2018) 0.4 0.9 2.3 -0.6 1.0 -0.3 -0.9 -0.1 0.5 -1.1 -1.3 0.7 -1.4 -1.5
Alzheimer’s Disease (in mother) 0.5 0.6 1.8 0.4 -0.1 0.3 0.4 -1.3 -0.9 -1.1 -1.4 -0.5 0.4 -0.3
Alzheimer’s Disease (in father) 0.1 0.1 0.6 0.1 -0.1 0.2 0.1 0.1 0.1 0.2 -0.6 -0.1 -0.1 0.8
Alzheimer’s Disease (including proxy) 0.5 0.7 1.4 0.8 0.5 0.8 0.7 -1.2 -0.8 -1.1 -1.0 -0.8 0.3 0.7
Crohns Disease (2017) 0.4 0.9 3.2 1.0 -0.7 0.7 1.1 -0.5 -0.9 1.0 0.9 -1.2 1.8 0.4
Irritable Bowel Disease (IBD) 0.2 0.6 2.3 -0.1 -1.5 -0.4 -0.0 0.1 -0.1 1.5 0.8 -0.0 1.0 0.2
Ulcerative Colitis (UC) 0.5 1.0 2.9 -1.0 -1.7 -1.2 -1.1 0.5 0.5 1.5 0.5 1.0 0.2 0.0
Major Depression (MDD) 0.5 0.6 1.1 -1.0 -0.7 -1.0 -1.1 0.7 0.9 0.4 -0.3 0.9 -0.5 -0.6
Reaction Time 0.5 0.9 4.0 -0.8 0.4 -0.8 -1.0 0.3 0.6 -1.0 -1.1 0.9 -2.0 -0.4
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.5 -0.4 -1.1 -0.6 -0.1 1.3 0.8 1.6 0.6 0.4 -0.3 0.9
Breast Cancer 0.2 0.6 3.6 0.4 0.2 0.4 0.7 -0.7 -0.5 0.2 0.7 -0.3 0.9 1.9
Ovarian Cancer 0.1 0.1 0.5 -0.1 0.0 -0.2 0.3 -0.1 -0.3 0.3 0.7 -0.0 0.4 -0.1
Prostate Cancer 0.1 0.2 0.4 0.3 0.6 0.3 0.3 0.6 0.6 -0.4 0.4 -0.2 -0.2 -0.5
Age at First Birth 0.7 1.0 1.7 -1.0 0.3 -1.1 -1.2 1.3 1.2 0.4 0.3 1.2 -1.2 1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 1.3 -0.1 -0.2 -0.3 -0.1 1.1 0.8 0.7 -0.4 0.0 -0.5 0.4
Coronary Artery Disease (CAD) 1.5 1.8 4.7 1.4 2.2 1.5 1.1 -1.6 -1.3 -1.7 0.2 -1.2 1.0 0.4
Crohns Disease (2012) 0.1 0.2 1.7 0.1 -1.3 -0.1 0.3 -0.4 -0.2 -0.0 -0.2 -0.2 0.5 -0.4
Mean Putamen Volume 0.4 0.4 1.8 0.0 1.3 0.0 -0.1 0.1 0.3 -1.2 -0.6 0.0 -0.8 -0.5
Fasting Glucose 0.3 0.4 1.0 -0.5 -1.0 -0.5 -0.2 0.2 0.8 -0.7 -1.0 0.5 -0.3 -0.8
HbA1C 0.2 0.2 0.5 -0.2 0.7 -0.2 -0.2 0.6 0.4 0.7 -0.3 0.2 -0.4 -0.4
HDL Cholesterol 1.1 1.9 5.2 0.8 -1.8 0.8 1.1 0.1 -0.8 2.2 2.3 -1.0 1.4 1.2
LDL Cholesterol 1.1 1.8 7.0 0.8 1.5 0.9 0.6 -1.9 -1.1 -2.6 -1.7 -0.7 -0.4 -1.0
Lupus 0.3 0.5 1.3 0.9 0.5 1.1 0.7 -0.0 -0.1 0.3 1.0 -0.7 0.7 0.5
Neuroticism (2016) 0.3 0.5 1.3 -0.5 -1.1 -0.5 -0.7 -0.2 0.2 -0.2 -1.1 0.4 -0.3 -1.1
Primary Biliary Cirrhosis 0.3 0.4 1.4 -0.7 0.0 -0.4 -0.7 0.6 1.1 -0.4 -1.2 0.7 -0.6 0.1
Rheumatoid Arthritis 2.8 3.9 11.5 -1.8 -2.1 -1.8 -1.7 2.7 1.9 3.4 1.9 1.7 -0.2 0.5
Schizophrenia (2014) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Triglycerides 0.9 1.5 5.2 -0.7 0.9 -0.7 -1.0 -0.1 0.8 -1.6 -2.3 0.7 -1.5 -1.4
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.2 -0.5 1.5 -0.5 -0.7 0.9 1.2 -0.5 -1.1 0.6 -1.4 -0.2
Ulcerative Colitis 2.1 3.0 5.3 -2.2 -2.3 -2.2 -2.1 1.4 1.7 1.5 0.3 2.2 -1.3 -0.2
Blood Eosinophil Count 0.3 2.0 5.5 -1.6 -0.4 -1.6 -1.7 1.8 1.6 0.5 0.1 1.6 -2.4 0.1
Blood Platelet Count 0.1 1.0 6.8 0.1 1.0 0.4 -0.2 -0.7 0.2 -2.6 -0.4 0.3 -1.4 -0.4
Blood Red Count 0.2 1.8 2.9 1.4 1.7 1.6 1.6 -0.3 -1.1 0.3 0.4 -1.5 1.6 1.6
Blood White Count 0.3 2.0 9.3 0.7 2.3 0.9 0.6 -1.8 -1.0 -3.0 -1.1 -0.6 -0.1 -0.8
Heel T-Score 0.4 3.1 10.9 -1.5 1.9 -1.4 -1.6 1.4 1.9 -1.4 -1.5 1.7 -3.3 -0.6
BMI 0.1 0.5 1.5 -0.3 0.7 -0.5 -0.4 0.5 0.4 -0.4 -1.1 0.2 -1.2 -1.0
Height 0.2 4.6 20.3 -0.4 -1.4 -0.5 -0.2 1.8 0.4 4.5 3.1 0.2 2.6 2.8
Waist Hip Ratio (WHR) 1.2 5.4 19.3 1.1 3.9 1.4 1.0 -2.2 -0.9 -4.4 -3.4 -0.9 -0.8 -1.5
Systolic Blood Pressure 0.6 3.0 4.9 2.0 1.8 2.2 1.8 -1.6 -1.9 -0.7 -0.2 -2.0 1.6 2.0
Smoking Status 0.3 0.7 2.4 0.5 -0.1 0.4 1.0 -1.3 -1.1 -0.4 -0.7 -0.7 1.5 0.1
Allergy or Eczema 0.5 1.3 4.7 -0.9 -2.2 -1.1 -1.1 0.9 1.0 0.1 -1.0 0.8 -1.2 -1.2
Cardiovascular Disease 0.0 0.1 0.2 -0.4 -0.1 -0.4 0.1 0.4 0.2 0.5 -0.1 0.4 -0.1 0.2
Hypothyroidism (self reported) 0.8 1.7 3.7 -1.5 -1.3 -1.3 -1.1 1.9 1.5 1.7 0.7 1.4 -1.1 0.3
Respiratory disease 1.5 3.4 6.2 -1.9 0.3 -2.1 -2.1 0.6 1.6 -1.2 -2.2 2.0 -2.5 -2.5
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.5 0.5 1.2 0.3 0.7 -0.3 -0.3 -0.5 -0.6 -0.5 -0.2 0.3
Lung FEV1/FVC ratio 0.2 0.9 3.9 0.0 -0.2 0.2 0.0 0.6 -0.2 1.5 2.0 0.1 0.5 1.6
Lung FVC 0.3 1.6 4.1 -1.2 -1.3 -1.2 -1.1 1.1 0.7 2.0 1.7 1.2 0.1 1.6
Neuroticism 0.1 0.2 0.5 -0.6 0.4 -0.2 -0.7 0.4 0.5 0.3 -0.2 0.6 -0.5 -0.5
Chronotype (morning person) 0.8 1.8 8.9 -0.7 -0.9 -0.6 -0.3 2.0 0.8 3.0 1.9 0.6 0.4 0.7
Hair Pigment 0.1 3.6 7.0 -2.1 -1.4 -2.3 -2.0 0.9 1.5 -0.8 -2.3 2.0 -2.6 -2.1
Tanning 0.3 3.4 10.7 2.0 0.8 2.0 2.0 -2.0 -2.2 -0.0 0.3 -2.1 3.3 0.7
Hand grip strength (left) 0.3 0.7 3.0 -0.9 -1.7 -0.7 -0.9 -0.5 -0.3 0.7 0.9 0.8 0.8 0.2
Number of treatments/medications taken 0.5 0.9 1.9 -1.3 -0.1 -1.4 -1.4 0.7 0.7 0.9 -0.2 1.2 -1.0 -0.2
Average weekly spirits intake 0.4 0.5 1.5 -0.6 -1.2 -0.6 -0.9 0.6 0.8 0.6 -0.0 0.7 -0.7 0.6
Sensitivity / hurt feelings 0.5 0.8 3.9 -0.2 -0.5 -0.2 -0.4 -0.7 0.1 -1.2 -2.0 0.2 -0.8 -1.2
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.1 -0.6 0.9 -0.6 -0.2 -0.3 0.1 -0.9 -0.9 0.6 -0.3 -1.1
Hearing difficulty/problems: Yes 2.1 3.2 11.0 1.4 3.3 1.6 1.1 -1.9 -1.1 -3.1 -1.6 -1.2 -0.1 -0.7
Relative age of first facial hair 0.7 1.5 2.6 -1.4 -0.9 -1.2 -1.2 1.3 1.1 1.5 1.6 1.4 -0.9 0.1
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 1.1 -0.2 -0.5 -0.3 -0.4 0.2 0.2 0.1 -1.0 0.1 -0.1 -0.4
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.9 -1.1 -0.7 -1.3 -1.0 0.8 1.0 0.3 -0.8 1.1 -1.4 -0.6
Ever had hysterectomy (womb removed) 0.6 0.7 2.1 -0.8 0.6 -0.8 -0.5 0.1 0.5 -0.9 -0.8 0.8 -1.1 -1.4
Systolic blood pressure, automated reading 0.1 0.2 1.3 0.3 0.4 0.5 0.1 -0.3 -0.5 0.4 0.2 -0.3 0.1 1.2
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.6 0.2 0.6 0.2 0.1 0.7 -0.1 1.3 1.3 -0.2 0.5 0.7
Angina 0.5 0.7 3.5 0.2 -1.9 0.1 0.2 -0.4 -0.5 1.0 -0.2 -0.3 0.8 1.3
Medication for hormone replacement therapy 0.3 0.3 0.9 0.5 0.0 0.3 0.3 -0.6 -0.3 -0.7 -1.0 -0.5 -0.1 -0.9
Vitamin and mineral supplements 2.0 2.7 4.3 2.0 1.0 1.7 1.9 -2.0 -2.0 -1.2 -0.1 -2.1 2.0 -0.1
Supplements: Zinc 0.7 0.8 1.5 -1.0 -0.3 -1.1 -0.8 1.1 0.9 1.2 0.9 1.0 -0.4 0.1
Medication: Co-codamol 0.5 0.6 2.9 -0.5 0.2 -0.5 -0.5 -0.1 0.2 -0.9 -1.2 0.5 -0.9 -1.7
Medication: Metformin 0.3 0.5 1.9 0.6 1.4 0.6 0.7 -0.5 -0.3 -0.9 -0.6 -0.6 -0.5 0.3
Diabetes (father) 1.0 1.3 3.0 1.2 1.5 1.2 1.4 -0.8 -0.9 -0.3 0.9 -1.1 0.6 1.7
Diabetes (mother) 1.7 2.1 4.8 1.1 1.2 0.9 1.3 -1.7 -1.0 -2.1 -2.2 -1.2 0.1 -1.9
Severe depression (siblings) 1.5 1.7 3.2 -1.6 -0.2 -1.7 -1.7 1.7 1.8 0.9 0.0 1.6 -0.8 0.3
Pack years adult smoking proportion 0.5 0.8 1.4 -1.2 -1.2 -1.0 -1.0 0.7 0.9 0.6 0.1 1.0 0.4 -1.0
Impedance of leg (right) 0.0 0.2 0.5 0.6 0.7 0.6 0.4 -0.4 -0.4 -0.7 0.0 -0.5 -0.1 0.2
Leg fat-free mass (left) 0.3 1.5 7.8 -0.6 -1.4 -0.9 -0.4 1.2 0.5 2.8 1.2 0.3 1.5 0.4
Trunk fat percentage 0.4 1.6 2.7 -1.2 -0.0 -1.4 -1.3 1.6 1.6 0.7 -1.5 1.1 -1.2 -1.2
Hand grip strength (right) 0.4 1.1 3.3 -1.1 -1.8 -0.9 -1.1 0.1 0.1 1.4 1.2 1.0 0.9 0.4
Townsend deprivation index at recruitment 0.3 0.4 1.6 0.1 1.3 0.1 0.1 -0.9 -0.7 -0.7 0.1 -0.0 -0.0 -0.7
Current tobacco smoking 0.3 0.5 2.1 -0.4 -0.1 -0.5 -0.1 -0.9 -0.4 -0.6 -1.1 0.3 0.5 -1.4
Average weekly fortified wine intake 1.1 1.3 2.5 -0.9 -0.9 -0.9 -1.1 1.5 1.1 1.6 0.3 0.9 -1.5 1.0
Maternal smoking around birth 0.4 0.5 1.6 -1.0 -1.3 -1.0 -0.8 -0.3 -0.0 0.6 -0.0 0.9 0.2 -0.1
Fed-up feelings 1.5 2.8 4.8 -2.2 -1.6 -2.1 -2.1 1.3 1.8 0.4 -1.2 2.0 -0.6 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.5 -0.7 0.4 -0.7 -0.6 0.2 0.4 -0.1 -0.6 0.7 -0.2 -0.2
Relative age voice broke 0.4 0.7 3.1 -0.2 0.9 -0.1 -0.2 1.2 0.9 0.7 1.8 0.4 -0.4 0.1
Taking other prescription medications 1.6 2.4 5.1 -1.7 -0.7 -1.8 -1.7 1.5 1.7 0.5 -1.6 1.6 -2.2 -1.2
Age when periods started (menarche) 0.1 0.3 1.3 0.1 1.1 0.4 0.0 -0.8 -0.6 -0.9 0.1 -0.0 0.2 0.0
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.6 0.1 1.3 -0.1 0.3 -0.8 -0.3 -1.5 -0.6 -0.1 -0.7 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 4.6 -1.2 -0.0 -1.0 -1.3 1.9 1.8 0.5 0.3 1.3 -2.1 0.8
Tinnitus: Yes, but not now, but have in the past 2.5 2.7 5.0 -1.9 1.3 -1.6 -2.2 1.2 1.8 -0.8 -1.3 2.0 -1.9 -1.2
Qualifications: CSEs or equivalent 0.4 0.5 1.4 0.4 1.2 0.5 0.4 -0.9 -0.7 -0.9 0.7 -0.3 0.4 -1.0
Serious illness, injury or assault to yourself 0.7 0.8 4.7 -0.2 0.2 -0.5 -0.5 -0.7 0.2 -1.5 -2.2 0.3 -0.6 -0.6
High blood pressure 0.6 1.5 2.6 1.3 1.3 1.3 1.5 -0.6 -1.3 0.6 0.9 -1.4 1.4 1.6
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.4 -0.4 -0.7 -0.5 -0.7 0.5 0.7 -0.5 -1.2 0.4 -1.1 -1.1
Multivitamins +/- minerals 1.8 2.3 5.4 -1.5 -1.8 -1.2 -1.2 1.9 1.5 2.3 1.4 1.5 -0.7 1.2
Stomach or abdominal pain in last month 0.2 0.2 1.5 -0.0 -1.2 -0.4 0.4 -0.3 -0.5 0.6 0.2 -0.1 0.2 0.1
Supplements: Glucosamine 0.8 1.1 3.3 -1.0 -0.5 -1.0 -0.8 1.0 0.5 1.8 1.5 1.0 0.1 1.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.8 0.1 -1.7 0.0 0.1 0.1 -0.4 1.4 0.0 -0.4 1.3 0.4
Medication: Atenolol 0.6 0.8 1.6 -1.3 -0.5 -1.2 -1.1 0.8 0.8 0.5 -0.3 1.2 -0.8 -0.6
Medication: Levothyroxine sodium 0.9 1.6 5.1 -1.0 -1.7 -1.0 -0.7 1.8 1.0 2.3 1.3 0.9 -0.3 0.3
Sitting height 0.8 6.0 26.4 -0.2 -2.1 -0.4 0.1 1.6 -0.2 5.1 3.7 -0.1 3.3 2.6
Chronic bronchitis/emphysema (father) 0.6 0.7 1.6 1.0 1.0 0.8 1.2 -0.8 -0.4 -1.1 -0.5 -1.0 -0.1 -0.6
High blood pressure (mother) 0.1 0.1 0.5 -0.4 -0.3 -0.2 -0.3 0.3 0.3 0.2 -0.7 0.3 -0.3 0.6
Body mass index (BMI) 0.1 0.6 0.9 -0.8 -0.4 -1.0 -0.7 0.9 0.8 0.7 -1.0 0.6 -0.8 -0.8
Impedance of leg (left) 0.0 0.1 0.4 0.5 0.3 0.6 0.3 -0.1 -0.2 -0.2 0.5 -0.3 0.1 0.4
Leg predicted mass (left) 0.3 1.6 8.0 -0.7 -1.4 -1.0 -0.4 1.3 0.5 2.8 1.2 0.4 1.4 0.4
Trunk fat mass 0.3 1.1 2.6 -1.1 -0.6 -1.3 -1.0 1.6 1.3 1.6 -0.7 0.8 -0.3 -0.7
Waist circumference 0.3 1.0 3.5 -0.5 1.1 -0.7 -0.5 0.7 0.9 -0.5 -1.9 0.4 -1.0 -1.6
Number of incorrect matches in round 0.1 0.1 0.3 -0.0 0.2 0.2 -0.5 0.4 0.3 0.2 0.6 0.1 -0.5 0.3
Past tobacco smoking 0.2 0.4 1.1 0.1 1.0 0.3 -0.3 1.1 0.7 0.1 0.6 0.1 -1.1 0.0
Alcohol usually taken with meals 0.8 1.3 3.2 1.0 -0.0 0.8 1.2 -0.9 -1.5 0.8 1.1 -1.2 1.8 1.1
Nervous feelings 0.5 0.9 3.5 0.6 1.9 0.9 0.3 -1.2 -0.7 -1.5 -0.6 -0.4 -0.2 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 4.6 0.5 0.8 0.7 0.2 -2.1 -1.1 -2.1 -1.6 -0.5 0.2 -1.4
Hearing difficulty/problems with background noise 2.2 3.5 15.1 0.7 2.2 1.0 0.5 -2.3 -0.8 -3.9 -2.4 -0.6 -0.4 -2.1
Hair/balding pattern: Pattern 2 0.4 0.5 1.1 0.4 0.8 0.3 0.5 -0.9 -0.8 -0.9 -0.3 -0.5 0.7 -1.0
Had menopause 0.1 0.1 0.4 -0.3 -0.6 -0.4 -0.1 0.0 0.1 0.4 -0.1 0.2 -0.2 0.3
Had other major operations 0.2 0.2 1.0 -0.3 -0.6 -0.4 -0.1 -0.5 0.1 -0.0 -0.8 0.2 0.0 -1.0
Forced vital capacity (FVC) 0.5 1.9 6.8 -0.3 -1.0 -0.4 -0.5 0.9 0.0 2.6 2.4 0.2 1.5 1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 4.2 0.0 0.7 0.3 -0.2 1.0 0.7 0.5 1.0 0.2 -0.9 2.0
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.3 -0.8 1.2 -0.7 -0.7 -0.2 0.6 -1.1 -0.9 0.9 -0.5 -1.0
Qualifications: None of the above 0.8 1.7 4.9 -1.0 0.9 -0.9 -1.0 0.2 1.0 -1.5 -2.2 1.1 -1.6 -1.8
Financial difficulties in last 2 years 0.3 0.4 1.6 0.1 -1.3 -0.1 0.5 -0.1 -0.5 1.0 0.4 -0.2 0.9 0.2
Mouth/teeth dental problems 1.7 2.6 11.7 1.2 0.4 1.2 1.1 1.4 0.0 2.2 1.8 -1.2 0.9 3.4
Heart attack 0.2 0.3 1.8 0.4 -0.5 0.2 0.3 -0.1 -0.2 0.5 -0.6 -0.5 0.3 1.3
Allergy 0.5 1.2 3.0 0.9 0.7 1.0 1.2 -0.7 -1.1 0.5 1.7 -0.8 1.4 1.5
Pain all over the body in last month 1.5 1.6 2.9 -1.6 -1.0 -1.6 -1.7 1.2 1.7 0.5 -1.2 1.5 -1.0 -0.2
Diabetes (self-reported) 0.4 0.6 2.1 0.6 1.4 0.5 0.8 -0.6 -0.4 -0.7 -1.1 -0.6 -0.1 0.4
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.1 -1.0 0.2 -1.1 -1.3 0.4 0.9 -0.8 -1.3 1.0 -1.7 -1.8
Medication: Ramipril 3.1 4.0 7.1 2.3 0.8 2.3 2.7 -2.6 -2.6 -1.3 -1.2 -2.5 1.5 -0.2
Medication: Simvastatin 0.5 0.8 2.4 0.7 1.5 0.9 0.8 -0.4 -0.1 -1.5 -1.2 -0.6 -0.5 -0.2
Fluid intelligence score 0.4 0.7 3.3 -0.6 -1.8 -0.9 -0.2 1.0 0.8 1.3 -0.3 0.5 -0.1 0.0
Illnesses of siblings 0.6 0.8 1.5 1.0 1.2 1.0 1.0 -1.1 -1.2 -0.5 0.4 -0.9 0.7 0.2
Neuroticism score 0.4 0.7 1.6 -0.8 0.9 -0.5 -1.1 -0.1 0.6 -1.0 -1.1 0.9 -0.7 -1.2
Weight 0.3 1.3 6.7 -0.9 -1.2 -1.1 -0.7 1.5 0.9 2.6 0.4 0.6 0.6 0.1
Impedance of arm (right) 0.4 1.7 8.0 0.7 2.8 0.6 0.4 -0.6 -0.1 -2.3 -1.8 -0.5 -0.8 -0.3
Arm fat percentage (right) 0.2 0.8 3.5 -0.3 1.0 -0.5 -0.4 0.7 0.9 -0.4 -1.9 0.2 -1.1 -1.1
Trunk fat-free mass 0.7 4.3 18.1 -0.1 -2.5 -0.4 0.2 1.3 -0.1 4.3 3.1 -0.2 2.8 1.9
Hip circumference 0.4 1.7 4.4 -1.2 -0.7 -1.5 -1.2 2.1 1.6 1.9 -0.2 1.0 -0.7 -1.0
Time employed in main current job 1.8 2.1 4.3 1.7 1.9 1.8 2.1 -1.1 -1.2 -1.1 0.8 -1.6 1.0 -0.9
Alcohol intake versus 10 years previously 0.7 1.1 2.4 -1.4 -1.5 -1.1 -1.6 0.7 1.1 0.2 -0.2 1.3 -0.0 -0.9
Father’s age at death 0.7 0.9 1.8 -1.0 -0.6 -1.2 -1.3 1.2 1.3 0.2 -0.4 1.1 -1.2 -0.3
Worrier / anxious feelings 0.4 0.7 2.4 0.2 1.0 0.3 -0.2 -1.0 -0.4 -1.5 -1.1 -0.0 -0.8 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 2.3 -0.5 0.7 -0.4 -0.6 -0.4 0.0 -0.8 -1.5 0.4 -0.6 -0.8
Falls in the last year 1.0 1.3 3.7 -0.4 1.4 -0.2 -0.6 -1.0 -0.2 -1.9 -1.7 0.4 -1.0 -1.8
Hair/balding pattern: Pattern 3 0.6 0.9 2.0 1.4 0.1 1.4 1.1 -0.9 -1.2 -0.1 0.2 -1.4 0.4 0.8
Number of live births 0.3 0.4 1.7 -0.4 1.3 -0.2 -0.4 0.5 0.6 -0.1 1.0 0.5 -0.1 -0.4
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 7.1 -0.3 -0.8 -0.2 -0.5 0.8 -0.2 2.6 2.7 0.2 1.8 1.9
Pulse rate 0.1 0.2 0.6 0.1 0.2 0.2 0.2 0.8 0.3 0.4 0.4 -0.0 -0.6 -0.6
Happiness 0.8 1.0 1.5 -1.2 -1.1 -1.2 -0.9 1.2 1.0 1.2 -0.5 1.1 -1.0 0.1
Noisy workplace 2.2 2.7 4.5 -1.7 -2.0 -1.7 -2.1 0.7 1.6 -0.9 -1.6 1.8 -1.9 -1.5
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.4 -1.0 -1.6 -1.0 -1.0 -0.3 0.4 -0.4 -0.0 1.0 -0.5 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.6 0.1 -1.3 -0.0 0.2 -1.2 -0.8 -0.2 -0.1 -0.3 1.1 -0.9
Mouth/teeth dental problems: Dentures 2.3 3.8 10.4 -2.0 -0.6 -2.1 -1.6 -0.3 1.2 -1.6 -2.9 1.9 -2.0 -3.2
Asthma 0.8 1.6 4.2 -0.6 1.5 -0.8 -0.7 0.9 1.3 -1.0 -1.8 0.6 -2.1 -1.7
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 2.7 -0.5 1.6 -0.6 -0.7 1.2 1.1 0.0 -0.1 0.6 -0.5 -0.2
Medication: Cholesterol lowering 0.3 0.4 2.1 0.2 0.4 0.4 0.4 -0.4 0.0 -1.2 -1.4 -0.2 -0.3 0.1
Depression (self-reported) 1.0 1.1 2.2 -1.3 1.0 -1.1 -1.4 0.8 1.3 -0.5 -0.4 1.5 -1.4 0.1
Medication: Lansoprazole 0.3 0.3 1.4 -0.2 -0.3 -0.3 -0.3 -0.6 -0.2 -0.8 -0.9 0.2 -0.6 -1.2
Prospective memory result 0.6 0.7 1.7 -1.0 -1.1 -0.8 -0.7 1.0 0.9 0.5 -0.1 1.0 -1.3 -0.0
Lung cancer (father) 0.5 0.6 2.2 -0.5 -0.0 -0.4 -0.6 0.3 0.6 -1.0 -1.5 0.6 -1.1 -0.8
Illnesses of mother 0.5 0.6 1.9 -0.1 1.1 -0.1 -0.1 0.2 0.7 -1.4 -0.9 0.2 -0.8 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 4.3 -0.1 -0.2 -0.2 -0.5 0.6 -0.2 1.9 2.1 0.1 1.3 1.7
Pulse wave Arterial Stiffness index 0.7 0.8 2.1 -0.8 -0.7 -0.9 -0.8 1.2 0.8 1.4 0.6 0.7 -0.2 1.2
Impedance of arm (left) 0.3 1.4 4.4 -0.0 1.9 0.0 -0.3 -0.1 0.6 -2.1 -2.0 0.1 -1.2 -1.0
Arm fat mass (right) 0.2 1.0 2.2 -1.0 -0.1 -1.3 -1.0 1.5 1.3 1.1 -0.9 0.8 -0.7 -0.9
Trunk predicted mass 0.7 4.2 17.6 -0.2 -2.6 -0.4 0.2 1.3 -0.0 4.2 3.0 -0.1 2.7 1.8
Standing height 0.5 5.4 23.1 -0.4 -2.3 -0.6 -0.1 1.8 0.3 4.8 3.4 0.1 3.2 2.3
Length of working week for main job 0.6 0.7 3.0 0.4 0.0 0.4 0.3 -0.1 -0.7 1.1 1.2 -0.5 1.7 0.7
Exposure to tobacco smoke at home 0.3 0.3 0.9 -0.6 0.9 -0.6 -0.5 0.5 0.6 0.0 -0.6 0.7 -0.3 0.4
Breastfed as a baby 0.4 0.4 1.3 -0.6 0.4 -0.6 -0.5 0.6 0.8 -0.3 -0.9 0.6 -1.2 -0.5
Tense / ‘highly strung’ 1.9 3.1 5.3 2.0 2.1 2.1 1.9 -2.3 -2.1 -1.3 0.1 -1.9 1.5 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.5 -0.2 1.2 -0.1 -0.1 0.1 0.6 -0.7 -0.5 0.3 -0.4 -1.2
Hair/balding pattern: Pattern 4 0.5 1.3 3.0 -1.0 -0.2 -1.0 -1.3 0.4 1.1 -1.2 -1.7 1.1 -1.6 -1.0
Birth weight of first child 1.3 2.4 5.3 1.3 -1.4 1.2 1.5 -0.4 -1.3 1.7 2.0 -1.5 2.3 1.4
Peak expiratory flow (PEF) 0.2 0.5 2.6 -0.4 -0.2 -0.3 -0.5 0.6 0.1 1.6 1.3 0.3 0.6 0.6
Pulse wave reflection index 0.2 0.2 1.4 -0.2 0.5 -0.2 -0.5 0.0 0.2 -0.1 -0.3 0.3 -0.1 1.2
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 -0.4 0.3 -0.5 -0.1 -0.3 0.0 -0.3 0.2 0.4 0.2 0.2
Loud music exposure frequency 0.8 0.9 4.4 0.1 0.4 0.1 0.1 -1.4 -0.6 -2.1 -1.0 0.0 -0.3 -1.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 2.8 -0.1 -1.7 -0.1 -0.5 -0.6 -0.6 0.1 0.8 0.1 0.5 0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 3.6 -0.1 -0.0 -0.0 -0.1 -0.7 -0.2 -1.4 -0.9 0.1 -0.1 -1.9
Blood clot in the leg (DVT) 0.0 0.0 0.1 -0.2 0.1 -0.1 -0.4 -0.2 -0.0 -0.3 -0.1 0.2 -0.1 0.1
Medication: Paracetamol 0.5 0.8 2.0 -1.1 -1.4 -1.1 -0.8 0.5 0.7 0.8 -0.3 0.9 0.3 -1.0
Headache pain in last month 1.4 2.5 3.7 -1.8 -1.9 -1.9 -1.6 1.4 1.7 0.2 -1.0 1.6 -1.2 -1.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.8 -0.8 -1.2 -1.0 -1.0 1.0 0.7 1.3 1.3 0.8 -0.5 -0.1
Glaucoma (self-reported) 0.8 1.0 3.4 1.1 1.8 1.1 0.9 -0.8 -1.1 -0.3 1.0 -1.0 0.4 0.2
Gout (self-reported) 0.3 0.4 2.1 -0.0 0.8 -0.0 -0.1 -0.8 -0.3 -1.5 -1.0 0.2 -0.1 0.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.9 -1.3 -1.1 -1.2 -0.9 1.7 1.2 1.7 0.7 1.2 -0.8 0.2
Medication: Amlodipine 0.6 0.9 2.1 1.3 -0.2 1.0 1.4 -0.8 -1.3 0.1 -0.2 -1.4 0.6 0.5
Medication: Ventolin 100micrograms inhaler 0.0 0.1 0.2 -0.2 -0.2 -0.3 -0.2 -0.1 -0.1 0.3 0.1 0.2 0.1 -0.5
Birth weight 0.9 2.0 7.2 -0.1 -1.6 -0.1 -0.0 1.3 0.4 2.7 2.2 -0.0 1.7 1.6
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.5 -0.2 0.0 -0.3 -0.1 0.1 0.3 0.3 0.1 0.2 -0.2 -0.7
High blood pressure (siblings) 0.1 0.1 0.3 -0.1 -0.5 0.0 -0.2 0.0 0.0 0.0 -0.6 0.0 0.1 -0.4
Forced vital capacity (FVC), Best measure 0.3 1.0 3.0 -0.6 -0.4 -0.7 -1.0 0.8 0.3 1.7 1.7 0.6 0.9 1.2
Body fat percentage 0.3 1.1 2.0 -0.9 0.1 -1.2 -0.9 1.4 1.4 0.6 -1.4 0.8 -1.1 -1.0
Leg fat percentage (right) 0.1 0.3 0.9 -0.4 -0.1 -0.6 -0.3 0.6 0.5 0.5 -1.0 0.2 -0.7 -0.7
Arm fat-free mass (right) 0.7 3.7 17.3 -0.8 -2.5 -1.0 -0.4 1.8 0.6 4.2 2.6 0.5 2.0 1.2
Exposure to tobacco smoke outside home 0.5 0.7 3.7 -0.7 -1.9 -0.7 -0.6 0.4 0.2 1.2 0.5 0.5 0.5 0.2
Comparative body size at age 10 0.2 0.6 2.5 0.5 -1.6 0.5 0.2 -0.9 -1.0 -0.0 -0.3 -0.5 0.7 0.7
Number of full brothers 0.1 0.1 0.5 0.2 0.3 0.3 0.3 0.2 -0.2 0.6 0.1 -0.3 0.7 0.2
Worry too long after embarrassment 0.5 0.8 1.5 1.1 1.2 1.1 0.9 -1.0 -1.1 -0.6 0.2 -1.0 0.2 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.2 0.2 0.2 0.2 0.3 -1.1 -0.6 -0.8 -0.4 -0.2 0.5 -0.3
Wheeze or whistling in the chest in last year 1.1 2.0 7.7 -1.1 0.6 -1.4 -1.0 0.8 1.3 -1.0 -1.6 1.0 -1.6 -2.8
Number of children fathered 0.7 0.8 3.1 -0.3 -0.2 -0.3 -0.6 0.5 -0.1 1.8 1.7 0.3 0.9 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 1.9 -0.0 -1.4 0.4 -0.0 -0.5 -0.4 0.1 0.1 -0.0 -0.1 0.8
Age at first live birth 0.1 0.2 0.5 -0.2 -0.7 -0.2 -0.5 -0.0 0.3 -0.5 -0.3 0.4 -0.6 0.4
Pulse wave peak to peak time 0.6 0.7 1.2 0.8 0.4 0.9 0.9 -1.1 -0.9 -1.0 -0.3 -0.8 0.5 -1.1
Health satisfaction 0.5 0.6 1.3 -0.9 1.2 -0.9 -1.0 0.5 0.5 0.1 -0.3 0.9 -0.9 -1.0
Shortness of breath walking on level ground 0.6 0.7 1.3 0.7 1.1 0.9 0.6 -1.1 -1.1 -1.1 -0.8 -0.8 0.4 -0.1
Qualifications: College or University degree 0.1 0.4 2.0 0.5 -1.4 0.4 0.3 -0.5 -0.2 -0.8 -0.5 -0.5 -0.1 0.1
Eye problems/disorders: None of the above 0.4 0.5 1.0 -0.9 -0.9 -0.7 -1.0 0.4 0.8 0.2 -0.4 0.9 -0.6 0.6
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.3 -1.3 -0.1 -1.2 -1.5 0.6 0.8 -0.0 0.0 1.4 -1.4 -0.4
Emphysema/chronic bronchitis 1.3 1.5 4.0 1.0 -0.3 1.1 1.2 -2.0 -1.4 -1.0 -0.6 -1.2 1.6 -1.1
Medication for pain relief, constipation, heartburn 0.3 0.5 0.7 0.8 -0.1 0.8 0.6 -0.8 -0.7 -0.6 0.4 -0.8 0.7 0.8
Neck or shoulder pain in last month 0.9 1.3 4.2 -1.1 -2.0 -1.2 -0.7 1.5 1.4 1.3 0.2 0.9 -0.1 -0.6
Medication: Blood pressure 0.8 1.4 2.3 1.4 1.4 1.5 1.4 -0.9 -1.1 -0.8 -0.4 -1.4 1.0 1.3
Angina (self-reported) 0.6 0.8 2.9 0.4 -1.7 0.4 0.4 -0.6 -0.7 0.8 -0.2 -0.6 1.0 1.4
Migraine (self-reported) 0.2 0.2 0.4 -0.5 -0.2 -0.4 -0.5 0.6 0.7 0.6 0.3 0.5 -0.1 0.4
Medication: Ibuprofen 0.3 0.4 2.5 -0.3 1.6 -0.4 -0.5 0.5 0.6 -0.3 -0.3 0.4 -0.4 -0.3
Medication: Allopurinol 0.5 0.6 1.2 -0.9 0.3 -0.9 -0.8 0.8 0.9 -0.1 -0.0 1.1 -0.8 0.9
Medication: Omeprazole 0.6 0.7 3.9 -0.3 -0.1 -0.6 -0.2 -0.5 -0.2 -0.4 -1.7 0.1 -0.5 -2.0
Medication: Seretide 50 evohaler 0.3 0.3 1.0 0.8 -1.0 0.6 0.5 0.0 -0.3 0.6 0.2 -0.8 0.1 0.5
Mean time to correctly identify matches 0.2 0.4 1.7 -0.2 0.4 -0.1 -0.3 -0.3 -0.2 -1.1 -0.9 0.2 -1.3 -0.3
Heart disease (mother) 0.5 0.6 2.8 0.1 -0.7 -0.0 0.1 0.1 -0.3 1.2 1.7 -0.2 0.3 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 1.3 0.3 -1.1 0.1 0.6 -0.1 -0.2 0.2 -0.7 -0.4 0.1 -0.1
Whole body fat mass 0.4 1.6 3.2 -1.3 -0.8 -1.6 -1.2 1.8 1.5 1.6 -0.8 1.1 -0.7 -0.9
Leg fat mass (right) 0.2 0.8 2.6 -0.8 -0.7 -1.1 -0.6 1.3 0.9 1.6 -0.4 0.6 -0.2 -0.7
Arm predicted mass (right) 0.9 4.6 21.3 -0.8 -2.8 -1.0 -0.4 1.9 0.5 4.6 3.0 0.6 2.2 1.5
Pulse rate, automated reading 0.3 1.1 4.7 -0.7 0.2 -0.8 -0.6 1.1 1.1 -0.4 -0.8 0.7 -1.4 -2.2
Alcohol intake frequency. 0.9 2.2 3.0 1.6 1.1 1.6 1.6 -1.7 -1.6 -1.3 -0.7 -1.7 1.3 -1.4
Comparative height size at age 10 0.1 0.6 3.0 0.3 -1.1 0.0 0.6 -0.3 -0.7 1.0 -0.7 -0.6 1.7 0.1
Number of full sisters 1.4 1.7 3.6 -1.8 -0.5 -1.9 -1.5 1.2 1.8 0.1 -0.3 1.8 -1.2 -0.1
Suffer from ‘nerves’ 2.4 3.8 6.4 -2.3 0.3 -2.1 -2.4 1.2 2.3 -1.2 -1.7 2.4 -2.5 -2.0
Overall health rating 0.2 0.4 1.8 0.1 1.3 -0.1 0.3 0.1 -0.3 1.0 0.0 -0.2 0.2 1.4
Chest pain or discomfort 0.1 0.1 0.6 0.2 -0.7 0.0 0.3 0.2 -0.0 0.3 -0.8 -0.3 0.0 0.2
Had major operations 1.6 1.8 4.0 1.2 2.0 1.1 1.1 -1.9 -1.7 -1.3 -0.3 -1.2 1.3 -0.4
Age at last live birth 0.3 0.4 0.9 -0.4 0.8 -0.1 -0.9 0.3 0.7 -1.0 0.1 0.6 -0.2 -0.6
Family relationship satisfaction 0.3 0.4 0.9 -0.7 -0.6 -0.7 -0.2 0.6 0.4 1.0 -0.2 0.7 -0.7 -0.1
Leg pain on walking 1.2 1.5 2.7 1.4 1.3 1.3 1.4 -1.1 -1.4 -0.3 0.8 -1.4 1.6 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.8 0.9 1.1 1.0 0.8 -0.9 -1.0 -0.4 1.2 -0.8 1.3 -0.1
Commuting to job workplace: Car/motor vehicle 1.0 1.1 3.1 -0.6 -0.6 -0.7 -0.4 1.8 1.4 1.5 0.0 0.7 -0.8 1.6
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 1.0 0.1 0.3 0.1 -0.2 1.0 0.7 0.4 0.4 0.0 -0.9 0.2
Medication: Aspirin 0.3 0.4 1.1 0.7 0.9 0.9 0.6 -0.2 -0.2 -0.1 -0.2 -0.7 -0.0 1.0
Supplements: Vitamin C 0.3 0.3 0.9 -0.1 0.9 -0.1 -0.1 -0.0 0.2 -0.8 -1.0 0.2 -0.9 -0.6
Knee pain experienced in last month 1.3 2.1 3.8 1.6 0.6 1.4 1.7 -1.9 -1.5 -1.4 -0.5 -1.7 1.6 -1.3
Hypertension (Self-reported) 0.7 2.0 3.1 1.5 1.3 1.5 1.8 -0.8 -1.6 0.5 0.9 -1.6 1.7 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.3 0.1 -0.8 -0.0 0.2 -0.3 -0.1 -0.2 -1.2 -0.2 -0.3 1.1
Illnesses of father: Heart disease 0.2 0.3 0.7 -0.3 -0.5 -0.2 -0.2 -0.8 -0.5 -0.1 0.5 0.3 0.7 0.8
Illnesses of siblings: Diabetes 1.7 2.1 4.2 -1.5 -0.7 -1.4 -1.7 1.2 1.8 -0.5 -1.7 1.6 -2.0 -1.0
Smoking status: Previous 0.3 0.4 1.2 0.3 -1.1 0.0 0.6 -0.7 -0.6 0.3 -0.0 -0.4 1.1 0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 7.3 1.3 0.2 1.0 1.5 -0.4 -1.2 1.6 1.9 -1.4 2.7 2.3
Whole body fat-free mass 0.6 3.4 16.0 -0.4 -2.3 -0.7 -0.1 1.4 0.2 4.0 2.6 0.1 2.3 1.3
Leg fat-free mass (right) 0.3 1.8 9.1 -0.6 -1.5 -0.8 -0.3 1.2 0.4 3.0 1.5 0.3 1.7 0.6
Arm fat percentage (left) 0.4 1.4 4.6 -0.9 0.6 -1.0 -0.9 1.0 1.4 -0.4 -2.1 0.7 -1.5 -1.5
Average weekly red wine intake 0.4 0.6 1.9 0.6 -0.3 0.6 0.5 -0.9 -1.4 0.4 1.2 -0.6 0.8 0.7
Handedness (chirality/laterality): Left-handed 1.6 1.9 4.2 -1.5 -0.8 -1.6 -1.6 0.2 0.8 -0.9 -2.0 1.5 -1.6 -1.7
Mood swings 0.5 0.9 2.6 0.8 1.3 1.1 0.5 -1.2 -1.1 -0.1 0.5 -0.8 1.6 0.6
Loneliness, isolation 1.4 2.0 4.1 -1.9 -0.4 -1.6 -2.0 1.6 1.7 1.0 0.0 1.9 -0.7 0.0
Long-standing illness, disability or infirmity 0.2 0.3 1.0 0.3 1.0 0.2 0.2 -0.4 -0.2 -0.7 -0.9 -0.3 -0.1 -0.8
Ever had bowel cancer screening 0.4 0.4 1.2 -0.7 -0.0 -0.9 -0.7 0.5 0.6 0.1 -0.5 0.7 -1.1 -0.8
Diabetes diagnosed by doctor 0.3 0.6 2.0 0.7 1.4 0.6 1.0 -0.5 -0.4 -0.7 -0.9 -0.8 -0.0 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.4 0.0 -0.1 0.3 0.2 -0.1 -0.4 0.9 0.9 -0.1 1.2 -0.0
Friendships satisfaction 0.2 0.3 1.2 -0.6 0.3 -0.5 -0.5 0.2 -0.1 0.7 0.1 0.6 -0.4 1.1
Qualifications: nursing, teaching 1.0 1.5 5.1 -0.8 -1.7 -1.0 -0.9 1.2 0.6 2.3 1.5 0.7 0.1 1.2
Commuting to job workplace: Walk 1.2 1.3 3.1 1.1 1.2 1.2 0.8 -1.8 -1.5 -1.1 -0.1 -1.1 1.0 -0.4
Eye problems/disorders: Cataract 0.3 0.3 1.0 0.5 0.2 0.3 0.8 -0.4 -0.3 -0.7 -0.3 -0.6 0.5 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.9 0.3 -0.5 0.3 0.3 -0.8 -1.0 0.2 0.7 -0.4 0.8 -0.1
Medication for cholesterol 0.3 0.5 3.3 -0.0 -0.1 -0.1 0.0 0.6 0.2 1.0 1.8 0.1 0.8 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.5 -0.8 -0.2 -0.7 -1.1 0.6 0.8 -0.3 -0.7 0.9 -1.2 0.1
Back pain experienced in last month 0.2 0.2 0.5 -0.6 -0.6 -0.7 -0.4 0.5 0.5 0.1 -0.4 0.5 -0.2 -0.6
Mineral and other dietary supplements 0.5 0.7 1.2 1.0 0.9 0.8 1.1 -0.6 -0.6 -1.0 -0.8 -1.0 0.6 -0.3
Breast cancer (self-reported) 0.8 1.0 3.4 1.0 0.6 0.8 0.6 -1.9 -1.5 -1.1 0.5 -0.9 0.8 -0.2
Asthma (self-reported) 0.8 1.6 3.9 -0.5 1.5 -0.7 -0.7 0.7 1.2 -1.2 -1.9 0.6 -2.0 -1.7
Osteoporosis (self-reported) 0.3 0.3 1.4 -0.5 -1.2 -0.5 -0.5 -0.1 -0.1 0.7 -0.2 0.4 0.3 -0.6
Osteoarthritis (self-reported) 0.4 0.5 1.7 0.6 -0.5 0.4 0.6 -0.1 -0.5 1.1 0.9 -0.6 1.3 0.5
Medication: Aspirin 0.3 0.4 0.9 0.7 0.9 0.9 0.7 -0.4 -0.3 -0.5 -0.7 -0.7 -0.1 0.7
Medication: Gliclazide 0.4 0.4 1.3 -0.5 -0.5 -0.6 0.1 1.1 0.9 0.7 -0.4 0.4 -0.7 -0.5
Illnesses of father: None of the above (group 1) 0.1 0.1 0.6 0.0 -0.4 -0.1 -0.3 0.5 0.2 0.4 0.3 -0.0 0.2 -0.8
Smoking status: Current 0.3 0.4 1.6 -0.6 -0.5 -0.6 -0.1 -0.7 -0.4 -0.3 -1.0 0.4 0.4 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 4.6 0.4 0.8 0.2 0.2 0.5 -0.5 1.7 2.0 -0.3 0.5 2.1
Whole body water mass 0.6 3.3 15.5 -0.4 -2.1 -0.6 -0.1 1.4 0.2 3.9 2.5 0.1 2.2 1.4
Leg predicted mass (right) 0.3 1.7 8.6 -0.5 -1.4 -0.7 -0.3 1.2 0.4 2.9 1.5 0.3 1.6 0.6
Arm fat mass (left) 0.4 1.7 2.8 -1.4 -0.3 -1.6 -1.3 1.7 1.7 0.9 -1.2 1.2 -1.0 -1.2
Number of self-reported non-cancer illnesses 0.3 0.6 1.4 -0.7 1.2 -0.7 -0.7 0.1 0.4 -0.5 -1.0 0.7 -0.8 -0.8
Average weekly champagne plus white wine intake 0.0 0.0 0.2 0.2 -0.2 0.2 0.2 0.4 -0.0 0.2 -0.1 -0.3 -0.1 0.1
Miserableness 1.6 2.8 5.4 -2.1 -0.2 -1.9 -2.1 2.2 2.3 1.0 -0.7 2.1 -1.4 -0.3
Guilty feelings 1.0 1.5 4.8 -0.2 2.0 0.1 -0.5 -1.2 -0.4 -2.2 -1.1 0.3 -0.4 -2.0
Wears glasses or contact lenses 0.2 0.2 0.5 0.4 -0.7 0.4 0.4 -0.4 -0.6 0.5 -0.1 -0.5 0.0 0.5
Ever taken oral contraceptive pill 0.8 0.9 1.9 -1.3 0.2 -1.3 -1.1 0.9 1.2 -0.1 -0.5 1.4 -1.0 0.5
Hearing aid user 1.1 1.3 3.1 -1.1 -0.5 -1.1 -1.2 0.8 1.2 -0.4 -1.8 1.1 -1.4 -1.2
Mother’s age at death 0.4 0.6 2.6 -0.5 -0.4 -0.5 -0.4 -0.0 0.4 -0.8 -0.9 0.6 -0.8 -1.6
Financial situation satisfaction 0.3 0.4 1.2 -0.8 -0.8 -0.9 -0.2 0.2 0.0 1.1 0.7 0.7 -0.2 -0.5
Tinnitus: Yes, now most or all of the time 2.2 2.6 11.9 -1.3 -0.5 -1.5 -1.2 -0.4 0.7 -1.5 -2.4 1.2 -1.0 -3.4
Commuting to job workplace: Public transport 2.1 2.5 8.3 1.8 2.9 1.8 1.5 -1.2 -1.3 -1.5 -0.3 -1.8 0.2 -1.2
Eye problems/disorders: Glaucoma 1.2 1.4 3.1 1.5 1.8 1.4 1.3 -0.7 -1.3 0.1 1.2 -1.4 0.9 0.6
Medication: Blood pressure 0.4 0.7 1.8 0.7 0.1 0.7 1.0 -1.3 -1.3 -0.2 -0.6 -0.9 0.9 0.0
Pain type(s) experienced in last month: Hip pain 1.0 1.2 3.2 1.0 0.8 0.7 1.3 -0.7 -1.4 0.7 1.2 -1.1 1.8 0.9
Supplements: Fish oil (including cod liver oil) 1.4 1.8 4.2 -1.5 -2.0 -1.4 -1.6 1.2 1.1 1.6 0.7 1.5 -1.0 0.4
High cholesterol (Self-reported) 0.6 1.1 3.3 -0.6 0.7 -0.4 -0.6 -0.1 0.7 -1.8 -1.6 0.7 -1.4 -1.3
Medication: Bendroflumethiazide 0.5 0.8 2.8 0.7 1.7 0.7 0.6 -1.0 -0.9 -0.6 -0.7 -0.9 1.2 0.0
Medication: Paracetamol 0.3 0.5 2.6 -0.6 -1.6 -0.6 -0.4 -0.2 -0.0 0.8 -0.2 0.4 0.8 -0.3
Medication: Lisinopril 0.1 0.1 0.8 0.1 -0.4 0.0 -0.0 -0.6 -0.3 -0.3 -0.4 -0.1 -0.1 0.9
Medication: Atorvastatin 2.3 2.8 5.7 -2.4 -0.6 -2.2 -2.3 0.8 1.3 0.1 -1.9 2.2 -1.9 -0.6
Illnesses of father: High blood pressure 1.1 1.3 2.4 1.3 -0.6 1.4 1.5 -1.5 -1.4 -0.5 0.4 -1.4 1.2 0.4
Alcohol drinker status: Never 1.7 2.0 3.7 1.9 1.7 1.8 1.7 -1.4 -1.7 -0.8 0.2 -1.8 0.7 0.4
Ever smoked 0.5 0.8 3.2 -0.2 -1.5 -0.5 0.2 -1.5 -1.1 -0.0 -0.1 -0.0 1.8 -0.6
Basal metabolic rate 0.5 2.6 12.7 -0.7 -2.0 -0.9 -0.4 1.5 0.5 3.6 1.9 0.4 1.8 0.8
Leg fat percentage (left) 0.1 0.4 0.7 -0.4 -0.5 -0.6 -0.4 0.7 0.6 0.8 -0.8 0.3 -0.6 -0.7
Arm fat-free mass (left) 0.6 3.2 14.9 -0.9 -2.3 -1.1 -0.5 1.6 0.5 3.9 2.3 0.6 1.8 1.0
Number of operations (self-reported) 1.1 1.6 5.6 1.1 -0.3 1.0 1.4 -1.7 -1.6 0.3 0.4 -1.2 2.4 0.5
Average weekly beer plus cider intake 0.1 0.2 1.0 -0.3 0.1 -0.1 -0.2 0.1 0.6 -0.3 -1.0 0.3 -0.2 0.3
Irritability 0.6 1.1 2.1 -1.0 -0.4 -0.9 -1.4 -0.8 0.2 -1.4 -1.4 1.0 -0.6 -1.4
Risk taking 0.9 1.3 4.7 0.8 -2.2 0.8 0.7 -1.0 -1.0 0.3 0.2 -0.8 1.8 0.9
Ever had prostate specific antigen (PSA) test 0.8 1.0 3.4 -0.2 1.2 -0.2 -0.3 -0.9 -0.1 -1.9 -1.0 0.4 -0.8 -1.7
Fractured/broken bones in last 5 years 0.2 0.3 1.2 -0.4 1.1 -0.2 -0.5 -0.1 0.4 -0.7 0.5 0.6 -0.2 -0.7
Age started oral contraceptive pill 0.2 0.2 1.1 -0.0 -0.6 -0.1 0.2 0.1 -0.1 0.9 0.3 -0.0 0.1 1.0
Diastolic blood pressure, automated reading 0.1 0.2 1.2 0.1 0.9 0.4 0.1 -0.1 -0.1 0.1 0.5 -0.0 0.0 1.1
Ever depressed for a whole week 0.9 1.1 3.6 -0.9 -0.5 -0.9 -1.0 -0.2 0.8 -1.4 -1.4 1.0 -0.5 -1.9
Unable to work because of sickness or disability 0.1 0.2 1.8 0.1 1.3 0.0 0.2 -0.1 -0.1 -0.1 0.3 -0.1 -0.0 0.2
Commuting to job workplace: Cycle 0.2 0.3 1.1 0.6 0.7 0.7 0.1 -0.4 -0.4 -0.4 1.1 -0.4 0.4 0.3
Myopia 1.5 2.1 3.9 2.0 1.3 1.9 1.8 -1.3 -1.6 -0.5 -0.1 -2.0 1.6 0.3
Vascular/heart problems diagnosed by doctor 0.2 0.5 2.0 -0.4 -1.0 -0.5 -0.7 0.1 0.6 -0.7 -0.3 0.6 -0.8 -1.4
Cholesterol lowering medication 0.3 0.4 1.9 0.2 0.5 0.2 0.2 -0.7 -0.3 -1.0 -1.4 -0.3 -0.3 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.9 -0.7 -0.7 -1.0 -0.6 -0.2 0.0 0.1 -1.1 0.5 -0.3 -1.7
Pain experienced in last month 0.6 0.9 3.5 0.9 1.9 1.2 0.7 -0.9 -1.0 -0.8 0.3 -0.8 -0.4 0.9
Supplements: Calcium 0.1 0.1 0.3 -0.1 0.4 -0.1 0.2 -0.2 -0.1 0.4 0.2 0.1 0.3 -0.6
Basal cell carcinoma (self-reported) 0.5 0.5 1.7 0.7 1.3 0.7 0.9 0.2 -0.2 0.6 0.9 -0.8 0.5 0.5
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.0 0.6 -0.6 0.5 0.6 -0.4 -0.5 0.6 -0.3 -0.7 0.7 1.4
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.1 -0.2 0.1 -0.1 -0.3 -0.1 0.1 -0.3 -0.2 0.2 -0.2 0.1
Heart disease (siblings) 0.2 0.2 0.5 0.6 -0.1 0.5 0.5 -0.7 -0.7 -0.3 0.2 -0.6 0.6 0.2
Alcohol drinker status: Previous 0.5 0.5 2.9 -0.1 0.8 -0.2 -0.2 -0.0 0.4 -1.0 -0.6 0.1 -0.7 -1.7
Pack years of smoking 0.7 1.0 2.2 -1.2 -1.5 -1.1 -1.0 1.0 1.1 0.9 0.1 1.1 0.3 -0.8
Impedance of whole body 0.1 0.4 1.9 0.3 1.4 0.4 0.0 -0.2 0.1 -1.2 -0.8 -0.2 -0.5 -0.3
Leg fat mass (left) 0.3 1.0 3.6 -0.9 -1.0 -1.1 -0.7 1.4 0.9 1.9 -0.2 0.6 -0.1 -0.6
Arm predicted mass (left) 0.7 3.4 15.8 -0.7 -2.4 -1.0 -0.4 1.7 0.5 4.0 2.4 0.4 1.9 1.2