Hub : Genes

ZNF680

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1130	0.0340	7.9e-12	0.116	0.120	0.118	0.120	0.108	5.9e-14	2.2e-14	3.2e-14	1.9e-14	4.7e-13
2	GTEx	Brain Caudate basal ganglia	0.2700	0.0940	4.7e-04	0.061	NA	0.075	NA	0.083	7.9e-03	NA	3.4e-03	NA	2.2e-03
3	GTEx	Brain Frontal Cortex BA9	0.2501	0.1099	2.5e-03	0.025	NA	0.018	NA	0.055	7.2e-02	NA	1.1e-01	NA	1.4e-02
4	GTEx	Cells EBV-transformed lymphocytes	0.2690	0.0750	6.2e-05	0.148	NA	0.117	NA	0.135	1.5e-05	NA	1.2e-04	NA	3.7e-05
5	GTEx	Esophagus Mucosa	0.1260	0.0570	1.5e-03	0.024	NA	0.059	NA	0.019	9.3e-03	NA	8.1e-05	NA	1.9e-02
6	GTEx	Esophagus Muscularis	0.0950	0.0380	1.6e-04	0.045	NA	0.051	NA	0.049	9.3e-04	NA	4.6e-04	NA	5.7e-04
7	METSIM	Adipose	0.0685	0.0261	3.1e-04	0.036	0.027	0.038	0.030	0.036	3.9e-06	6.0e-05	2.2e-06	1.9e-05	3.9e-06
8	ROSMAP	Brain Pre-frontal Cortex	0.1527	0.0384	0.0e+00	0.175	0.180	0.175	0.185	0.171	6.5e-22	1.5e-22	5.9e-22	3.3e-23	2.1e-21
9	YFS	Blood	0.0321	0.0145	2.8e-03	-0.001	0.007	0.003	0.007	0.002	5.9e-01	2.1e-03	2.8e-02	1.4e-03	6.2e-02
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0275	0.0187	7.7e-03	0.011	0.002	0.007	NA	0.003	1.7e-02	1.7e-01	4.8e-02	NA	1.3e-01
11	TCGA	Brain Lower Grade Glioma	0.0693	0.0491	7.6e-04	0.026	0.012	0.001	NA	0.013	5.1e-04	1.4e-02	2.4e-01	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.0	1.6	5.2	0.6	0.6	-1.2	-1.6	-1.2	-0.8	2.3	-0.3	1.5	-1.4	0.7
Bipolar Disorder or Schizophrenia	0.7	1.6	4.8	1.1	1.0	-0.5	-2.2	-0.6	-0.4	1.8	0.4	1.4	-1.9	0.9
Depressed Affect (Nagel 2018)	0.7	1.4	9.5	0.6	-0.2	-0.3	0.9	1.4	-1.0	0.8	0.7	3.1	0.7	-0.3
Depression (Nagel 2018)	0.6	0.8	4.5	0.5	0.4	-0.3	0.1	1.8	0.2	0.3	0.8	2.1	-0.2	0.0
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.3	-1.2	-0.9	1.3	1.3	-0.5	-1.8	-0.6	-1.1	-1.3	1.8	0.2
Neuroticism (Nagel 2018)	0.5	1.1	8.1	0.0	-0.3	-0.4	0.3	1.4	-0.6	0.8	0.7	2.8	0.3	-0.0
Schizophrenia (2018)	0.3	0.7	2.5	0.9	0.8	0.3	-1.6	0.2	0.2	0.5	0.8	0.6	-1.3	0.5
Schizophrenia vs Biploar Disorder	1.3	1.7	4.8	0.9	2.2	0.9	-1.2	1.9	-0.8	0.2	1.1	-0.9	-1.3	1.8
Worry (Nagel 2018)	0.1	0.2	0.6	0.3	0.3	-0.1	-0.6	0.4	-0.4	0.1	0.7	0.7	-0.8	0.4
Alzheimer’s Disease (in mother)	1.9	2.3	4.7	1.3	1.8	1.1	-1.6	1.5	0.7	1.1	2.2	0.7	-1.6	2.2
Alzheimer’s Disease (in father)	2.0	2.2	8.6	0.8	0.4	-1.7	-0.4	1.1	2.4	1.7	0.9	2.9	-0.7	-0.4
Alzheimer’s Disease (including proxy)	1.1	1.6	5.5	0.3	0.1	-1.4	-0.5	1.2	2.3	1.4	0.9	2.4	-0.9	0.1
Crohns Disease (2017)	0.3	0.6	1.3	1.1	0.6	0.4	-0.6	-0.2	-0.5	1.1	0.9	0.7	-0.7	1.0
Irritable Bowel Disease (IBD)	0.1	0.3	1.6	0.3	0.0	0.4	0.4	1.3	0.7	-0.6	0.3	-0.6	-0.1	-0.1
Ulcerative Colitis (UC)	0.6	1.2	3.2	-0.6	-0.7	-0.1	1.3	1.8	1.6	-1.4	-0.5	-1.0	0.4	-1.2
Major Depression (MDD)	0.6	0.7	1.7	-0.8	-1.1	0.2	0.9	1.3	-0.3	0.5	-0.1	1.1	0.8	-0.9
Reaction Time	1.1	2.0	6.9	2.6	1.9	0.3	-1.2	1.1	0.9	0.4	2.0	1.0	-1.6	0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.9	-1.2	-0.8	0.4	1.2	-0.8	-1.1	-1.7	-1.1	-1.4	1.4	-0.1
Breast Cancer	0.3	0.7	2.3	0.4	0.7	0.6	-1.1	1.5	1.3	-0.7	0.9	-0.3	-0.6	0.3
Ovarian Cancer	0.5	0.6	1.7	-1.1	-0.7	-1.1	0.5	0.1	0.2	0.2	-1.3	0.6	0.7	-1.0
Prostate Cancer	0.6	0.8	5.0	0.5	0.8	1.1	-0.6	-0.1	-2.2	-0.2	0.8	0.5	0.0	0.8
Age at First Birth	0.7	1.0	6.1	-0.6	-1.1	-0.9	0.4	-2.5	0.7	0.3	-1.1	-0.6	0.4	-0.5
Bipolar Disorder (2011)	1.3	1.2	2.7	-1.0	-1.4	-1.6	0.9	-0.7	0.0	0.7	-1.6	1.3	0.5	-1.4
Body Mass Index (BMI) (2010)	1.0	1.4	3.8	-0.9	-1.0	-1.9	1.0	0.7	1.1	0.8	-0.9	1.9	0.7	-1.3
Coronary Artery Disease (CAD)	0.7	0.8	2.6	-0.7	-1.1	-1.6	1.2	0.1	1.1	0.1	-0.8	-0.2	0.5	-0.8
Crohns Disease (2012)	0.2	0.3	0.7	0.9	0.4	-0.6	-0.6	-0.3	0.2	0.7	0.6	0.5	-0.8	0.4
Mean Putamen Volume	1.0	1.1	2.4	-0.7	-1.2	-1.1	0.6	-1.6	-1.0	1.1	-1.6	0.5	0.8	-1.0
Fasting Glucose	0.1	0.2	0.5	-0.0	-0.5	0.5	0.3	0.4	-0.1	0.2	0.5	0.7	0.0	-0.3
HbA1C	0.7	0.7	6.3	0.2	-0.2	0.6	0.5	-0.3	-2.5	-0.5	-0.4	0.1	0.8	-0.2
HDL Cholesterol	0.3	0.5	1.4	0.4	-0.6	0.8	0.6	-1.2	0.5	-0.6	0.0	-1.1	0.6	-0.5
LDL Cholesterol	0.9	1.4	4.1	-1.1	-1.7	-0.4	2.0	-0.9	-0.0	-0.4	-1.8	0.1	1.1	-1.3
Lupus	0.5	0.7	1.6	-0.5	-0.9	-0.8	1.3	-0.3	0.3	-0.4	-1.1	1.2	0.7	-1.0
Neuroticism (2016)	0.3	0.4	1.3	-0.3	-0.4	0.4	0.5	0.9	-0.5	-1.1	0.0	-1.1	0.3	-0.5
Primary Biliary Cirrhosis	0.9	1.2	2.5	1.5	1.3	0.5	-1.0	1.6	-1.0	-0.9	0.5	-0.9	-1.6	0.7
Rheumatoid Arthritis	0.4	0.5	2.2	1.1	-0.1	1.5	0.7	0.4	-0.5	0.3	0.7	-0.6	0.4	0.2
Schizophrenia (2014)	0.8	1.7	6.7	1.3	1.5	-0.9	-2.1	-0.2	0.0	1.3	0.7	-0.0	-2.6	1.0
Triglycerides	0.5	0.7	5.6	-0.2	-0.5	0.1	0.2	0.9	-0.6	0.9	0.3	2.4	0.4	-0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.2	1.1	0.9	-0.4	-0.7	-0.2	-1.0	0.8	0.5	1.0	-0.8	1.0
Ulcerative Colitis	0.7	1.0	2.1	-0.8	-1.1	0.3	1.4	-0.2	0.6	-1.4	-0.9	-1.0	1.1	-1.3
Blood Eosinophil Count	0.2	1.9	9.7	0.3	0.7	3.1	-0.3	1.6	-1.3	0.2	1.5	0.8	0.9	1.6
Blood Platelet Count	0.6	6.8	14.2	2.8	3.8	2.8	-2.9	2.0	-0.7	1.4	3.2	-0.3	-2.5	3.7
Blood Red Count	0.0	0.4	1.2	0.3	0.4	0.9	-0.7	-1.1	-0.2	0.9	-0.1	0.3	-0.0	0.8
Blood White Count	0.7	5.0	30.5	0.9	0.9	1.4	0.0	5.5	-0.4	1.9	2.1	3.4	0.6	1.0
Heel T-Score	0.1	0.7	4.8	1.1	0.5	0.6	0.1	-0.5	0.3	-2.2	0.4	-1.0	-0.5	-0.1
BMI	0.3	1.7	4.6	-1.6	-1.4	-0.1	1.8	1.6	-0.4	0.1	-1.1	1.4	2.1	-1.0
Height	0.2	3.0	9.2	-3.0	-0.6	1.6	1.0	0.5	-2.5	-2.5	-1.1	-1.6	1.8	-0.1
Waist Hip Ratio (WHR)	0.3	1.3	3.3	1.4	1.6	-0.7	-1.3	1.2	1.2	0.6	0.7	0.6	-1.8	0.3
Systolic Blood Pressure	0.4	2.0	4.5	1.3	1.8	1.9	-1.3	1.3	0.1	0.7	2.1	0.1	-1.3	1.8
Smoking Status	0.3	0.8	2.8	-0.9	-1.0	0.1	1.3	0.0	-0.7	0.9	-0.5	0.8	1.7	-0.1
Allergy or Eczema	0.2	0.4	1.7	-0.1	0.7	-1.3	0.1	-0.4	0.8	-0.1	-0.8	0.2	-0.6	0.4
Cardiovascular Disease	0.4	1.4	3.6	1.6	1.3	0.0	-0.1	1.9	-0.2	1.6	0.8	1.7	-0.9	0.8
Hypothyroidism (self reported)	0.3	0.6	2.7	0.2	0.1	1.2	0.3	1.6	-0.2	0.5	0.8	0.7	0.6	0.9
Respiratory disease	0.2	0.5	1.1	-0.9	-0.7	-0.8	0.6	-0.2	-0.3	1.1	-0.6	1.0	0.9	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.6	0.5	-0.3	-0.6	0.7	0.5	-0.5	0.5	-0.1	-0.2	-0.1
Lung FEV1/FVC ratio	0.0	0.2	1.1	-0.5	-0.1	0.4	0.1	0.8	-0.0	-1.0	0.1	-0.4	0.3	-0.4
Lung FVC	0.6	3.0	11.4	1.9	0.6	1.5	-1.4	-3.4	-2.0	-1.1	0.7	-2.3	-1.3	1.2
Neuroticism	0.3	0.8	2.3	-0.7	-1.5	-0.4	1.1	0.5	-0.3	-0.3	-0.1	1.4	1.1	-1.1
Chronotype (morning person)	0.2	0.5	1.4	-0.6	-0.8	-0.3	1.1	-0.5	1.2	-0.6	-0.5	-0.3	0.8	-0.6
Hair Pigment	0.1	1.6	3.5	1.8	1.7	0.3	-1.5	1.1	0.8	-1.0	1.7	-0.2	-1.9	0.0
Tanning	0.1	0.8	5.4	-0.9	-0.8	-0.9	-0.5	-2.3	0.2	0.6	-0.8	-0.0	-0.2	-0.3
Hand grip strength (left)	0.5	1.4	5.3	-1.5	-1.7	-0.7	0.5	-2.3	0.1	-0.3	-1.0	-0.3	1.0	-1.5
Number of treatments/medications taken	0.7	1.2	4.3	0.3	-0.7	-2.1	1.8	1.1	0.8	-0.2	-1.1	0.2	0.5	-1.3
Average weekly spirits intake	1.2	1.5	4.6	0.9	1.0	2.1	-0.6	2.0	-1.4	-0.1	1.4	0.2	-0.5	1.0
Sensitivity / hurt feelings	0.6	1.1	5.2	-0.5	-0.2	-1.0	0.4	1.7	0.7	1.4	0.1	2.3	0.4	0.2
Frequency of depressed mood in last 2 weeks	1.0	1.3	2.8	0.6	1.2	0.2	-1.3	1.7	0.5	0.6	1.7	1.4	-1.2	1.2
Hearing difficulty/problems: Yes	0.8	1.2	6.1	-0.2	0.3	-1.4	-0.0	1.4	1.3	1.0	-0.5	2.5	-0.3	-0.4
Relative age of first facial hair	0.2	0.5	1.6	-0.3	-0.5	-1.3	0.7	-1.1	0.5	-0.2	-0.9	-0.0	0.5	-0.4
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.1	-1.1	-1.7	-1.8	1.7	0.7	0.1	-0.2	-1.8	0.8	1.5	-1.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.6	0.1	0.3	0.2	-0.1	0.3	-0.8	-0.6	0.0	0.1	-0.0	0.0
Ever had hysterectomy (womb removed)	0.7	0.8	3.2	-0.3	-0.4	-0.7	0.5	-0.9	0.7	-1.8	-0.5	-1.5	0.4	-0.8
Systolic blood pressure, automated reading	0.7	2.1	5.8	1.6	1.8	1.9	-1.2	1.6	-0.1	0.2	2.4	0.9	-1.0	1.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	0.0	0.1	0.9	-0.2	0.8	-0.4	0.1	0.4	0.6	0.3	0.3
Angina	0.5	0.7	2.2	0.5	0.7	1.5	-0.4	0.8	-1.0	-1.0	1.1	-0.5	-0.2	0.7
Medication for hormone replacement therapy	0.3	0.3	1.1	0.4	0.4	-0.4	-0.1	-0.2	-0.9	-0.7	-0.3	-1.1	-0.8	-0.1
Vitamin and mineral supplements	0.7	1.0	5.0	0.2	0.4	0.7	-0.3	0.2	-0.3	1.7	1.0	2.2	0.4	1.0
Supplements: Zinc	1.1	1.2	3.3	1.4	1.5	0.3	-0.9	1.8	0.2	0.7	1.0	0.6	-1.6	0.7
Medication: Co-codamol	0.7	0.8	3.1	0.4	1.2	-0.1	-1.8	-0.8	-1.0	0.4	0.3	0.2	-1.2	0.9
Medication: Metformin	0.1	0.1	0.5	-0.4	-0.2	-0.2	-0.2	-0.0	0.1	-0.7	-0.2	-0.0	0.1	-0.4
Diabetes (father)	1.3	1.6	4.8	1.3	1.8	0.2	-2.2	-0.4	-1.0	-0.1	0.7	-1.2	-1.9	1.1
Diabetes (mother)	1.1	1.4	5.5	0.9	0.5	-0.9	-0.5	1.4	-0.0	2.4	1.4	1.7	-0.8	0.7
Severe depression (siblings)	0.3	0.3	1.3	-0.1	-0.1	-0.2	0.9	1.0	1.2	0.1	0.3	0.2	0.3	-0.5
Pack years adult smoking proportion	1.0	1.6	3.4	1.6	1.6	1.2	-1.0	0.0	-1.8	0.1	1.3	0.6	-0.9	1.8
Impedance of leg (right)	0.6	3.0	7.5	-2.6	-2.2	-1.3	1.5	-1.8	0.4	-0.7	-2.7	-0.8	1.7	-1.7
Leg fat-free mass (left)	0.3	1.4	5.0	-1.3	-0.2	0.7	0.6	2.2	-1.3	0.9	0.3	2.0	1.0	0.5
Trunk fat percentage	1.3	5.2	12.1	-2.8	-2.4	-0.4	2.8	3.5	0.4	0.1	-1.4	2.7	3.2	-1.9
Hand grip strength (right)	0.2	0.6	3.2	-1.0	-0.6	-0.6	-0.2	-1.8	-0.3	0.3	-0.7	0.3	0.3	-0.6
Townsend deprivation index at recruitment	0.5	0.7	2.0	-0.8	-0.7	0.9	0.6	1.4	-0.4	-0.7	0.4	1.2	1.2	-0.3
Current tobacco smoking	0.2	0.4	1.2	0.7	0.7	0.7	-0.1	-0.1	-0.7	0.4	0.8	-0.2	-0.3	1.1
Average weekly fortified wine intake	1.3	1.6	3.5	-1.4	-1.9	-0.8	1.3	-1.6	1.2	1.0	-1.0	0.6	1.5	-0.9
Maternal smoking around birth	0.3	0.4	1.1	-0.4	-0.3	0.5	-0.0	1.0	0.5	0.3	1.0	0.9	0.7	0.4
Fed-up feelings	0.1	0.2	0.5	0.3	0.1	0.2	0.5	0.7	-0.7	0.3	0.4	0.5	0.4	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	1.9	11.2	0.8	0.8	-0.6	-0.2	3.3	0.4	0.8	1.4	2.2	-0.8	0.6
Relative age voice broke	1.0	1.5	4.8	1.0	1.2	-1.6	-1.4	-2.2	0.2	0.3	-0.5	-1.1	-1.7	0.6
Taking other prescription medications	0.4	0.7	2.6	1.0	0.4	-1.6	0.2	-0.1	0.7	-0.9	-0.3	-1.2	-0.8	-0.4
Age when periods started (menarche)	0.7	1.7	4.5	-2.0	-1.2	-0.7	1.1	-1.4	-1.1	-1.0	-2.1	0.3	1.3	-1.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	5.6	-0.6	-0.1	1.2	0.5	-0.1	-0.1	-2.1	-0.6	-2.4	0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	8.8	2.1	2.7	1.4	-2.0	-0.4	-0.1	0.3	1.8	-1.6	-2.4	3.0
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	5.4	0.0	0.7	-1.2	-0.5	2.3	2.0	1.3	0.2	1.8	-1.6	-0.2
Qualifications: CSEs or equivalent	0.3	0.4	2.3	0.3	0.2	-0.1	-0.7	-0.4	0.2	-0.9	-0.1	-1.5	-0.7	-0.0
Serious illness, injury or assault to yourself	1.0	1.2	4.8	0.7	0.8	0.8	-0.7	2.2	-0.2	0.9	1.5	1.2	-0.5	1.1
High blood pressure	0.4	1.1	3.9	1.5	0.6	-0.2	0.1	2.0	0.4	1.2	0.7	1.8	-0.8	0.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	4.7	-0.3	0.1	-2.2	0.3	-0.6	0.9	0.4	-1.3	0.4	-0.4	-0.4
Multivitamins +/- minerals	0.3	0.4	1.5	-0.2	-0.1	-0.6	-0.3	0.0	0.5	-0.9	-0.8	-1.2	-0.7	-0.4
Stomach or abdominal pain in last month	0.3	0.4	1.9	-0.3	-0.6	-0.1	0.4	0.0	0.6	1.1	-0.3	1.4	0.4	-0.4
Supplements: Glucosamine	0.2	0.3	1.5	0.1	-0.0	0.7	-0.2	-0.2	-0.3	0.2	0.4	-1.2	-0.5	0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	1.0	0.9	-0.9	0.2	0.3	0.7	0.8	0.7	0.7	-0.5	0.6
Medication: Atenolol	0.3	0.3	0.9	-0.2	-0.1	-0.9	0.3	0.6	0.7	-0.7	-0.6	0.0	-0.1	-0.8
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.5	-0.7	-0.7	0.6	0.5	0.4	-0.2	-0.6	0.1	0.1	-0.6
Sitting height	0.2	1.7	5.7	-1.4	0.2	2.4	0.5	0.9	-2.2	-0.8	0.2	-1.1	1.3	1.3
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.9	0.6	0.2	0.0	0.1	-0.0	-0.4	0.9	-0.5	-0.5	0.4
High blood pressure (mother)	2.0	2.8	7.5	2.3	2.4	0.2	-1.7	2.5	-0.3	-0.3	1.6	0.7	-2.7	0.7
Body mass index (BMI)	0.2	1.0	4.5	-0.3	-0.4	0.2	0.8	2.1	-0.1	0.7	0.5	2.0	1.1	-0.1
Impedance of leg (left)	0.5	2.6	5.4	-2.3	-2.1	-0.6	1.4	-1.4	0.2	-1.2	-2.3	-1.3	1.7	-1.7
Leg predicted mass (left)	0.3	1.4	5.0	-1.3	-0.2	0.7	0.6	2.2	-1.2	0.8	0.3	2.0	1.0	0.5
Trunk fat mass	0.9	3.9	10.0	-2.6	-1.9	0.1	2.5	3.2	-0.2	0.1	-1.1	2.2	2.9	-1.4
Waist circumference	0.4	1.5	9.4	-0.9	-0.3	-0.0	1.1	3.1	0.2	0.3	0.2	1.9	1.2	-0.3
Number of incorrect matches in round	1.2	2.0	4.0	2.0	1.7	-0.5	-1.6	-0.2	1.1	0.3	1.8	1.6	-2.0	0.7
Past tobacco smoking	0.4	0.8	2.1	1.1	0.7	1.4	-1.1	0.6	-0.1	-0.3	1.4	0.2	-0.9	0.7
Alcohol usually taken with meals	0.4	0.7	2.5	0.0	-0.6	-0.7	0.1	-1.6	0.8	-0.9	-0.6	-1.1	-0.3	-0.8
Nervous feelings	0.9	1.7	3.0	1.0	1.6	1.2	-1.6	1.6	-0.8	-1.1	1.7	0.2	-1.4	1.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	8.4	0.3	1.0	-0.5	-1.1	2.9	0.7	0.5	1.3	1.4	-1.4	0.6
Hearing difficulty/problems with background noise	1.8	2.8	12.3	1.3	1.0	-1.0	-0.8	1.7	1.7	2.1	1.5	3.5	-1.2	0.2
Hair/balding pattern: Pattern 2	0.2	0.2	1.1	0.2	-0.0	0.2	0.5	0.2	1.0	-0.8	-0.0	-0.2	0.4	-0.3
Had menopause	0.9	1.2	2.8	1.7	1.3	1.2	-1.4	0.4	-0.1	-0.3	1.4	0.0	-1.1	1.2
Had other major operations	1.4	1.7	3.4	1.3	1.8	0.3	-1.3	1.0	1.1	1.6	1.8	0.6	-1.2	1.4
Forced vital capacity (FVC)	0.2	0.9	4.0	-1.0	-0.8	0.5	0.0	-1.5	-2.0	-0.4	-0.7	-0.8	0.7	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	8.9	2.0	2.5	1.7	-1.4	0.1	-0.1	0.2	2.0	-1.4	-1.6	3.0
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	6.1	-1.2	-0.9	-2.5	0.4	1.6	1.9	0.4	-1.4	1.3	0.1	-1.4
Qualifications: None of the above	1.6	3.3	7.3	2.2	1.9	2.0	-1.5	2.6	0.4	1.2	2.7	1.0	-1.4	1.9
Financial difficulties in last 2 years	1.2	1.6	3.8	0.3	0.7	1.6	-1.1	1.9	-0.1	1.1	1.9	1.5	-0.5	1.3
Mouth/teeth dental problems	2.5	3.8	6.7	-2.4	-2.1	-1.2	2.1	-1.3	1.4	-1.4	-2.3	-2.2	1.8	-2.6
Heart attack	2.6	3.3	7.0	-0.8	-2.4	-2.4	2.4	-0.7	1.1	-1.6	-1.6	-0.7	1.9	-2.7
Allergy	0.4	0.8	4.7	0.3	0.0	2.2	-0.3	1.0	-1.0	-0.6	1.4	-0.1	0.3	0.3
Pain all over the body in last month	1.4	1.5	4.5	-0.5	-1.3	-1.9	1.2	-0.3	1.0	-1.5	-1.2	-0.4	0.3	-2.1
Diabetes (self-reported)	0.2	0.3	2.1	0.3	0.4	-0.5	-0.4	1.4	0.3	-0.1	0.3	0.9	-0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	11.4	2.4	3.1	1.0	-3.4	-0.3	-0.4	1.2	2.1	-0.2	-3.4	2.9
Medication: Ramipril	0.9	1.1	4.4	1.1	1.0	0.1	-0.6	2.1	1.2	-0.3	1.5	0.6	-1.1	0.6
Medication: Simvastatin	0.8	1.2	3.3	1.2	0.6	1.8	0.3	1.2	-0.4	-1.6	1.0	-1.6	0.1	0.5
Fluid intelligence score	0.5	1.1	2.5	-1.6	-0.8	0.1	1.5	0.4	-0.6	-1.3	-1.0	-0.9	1.6	-0.1
Illnesses of siblings	0.3	0.5	1.5	-0.8	-0.7	-0.6	0.7	-1.2	0.3	0.6	-0.5	-0.7	0.5	0.1
Neuroticism score	0.3	0.6	1.8	-0.2	-0.5	-1.0	0.6	1.2	0.7	0.8	0.4	1.3	0.1	-0.2
Weight	0.3	1.7	5.2	-1.8	-1.0	0.4	1.4	2.3	-0.6	0.1	-0.3	1.8	1.9	-0.4
Impedance of arm (right)	0.5	2.4	5.3	-2.3	-1.5	-1.2	1.7	1.3	1.6	-1.0	-1.8	0.5	1.5	-1.9
Arm fat percentage (right)	0.6	2.4	8.6	-1.4	-1.2	-0.4	1.8	2.9	1.0	0.4	-0.4	2.2	1.9	-1.1
Trunk fat-free mass	0.1	0.7	3.7	-0.8	0.2	1.3	-0.0	-0.2	-1.9	-0.2	0.2	-0.3	0.5	1.0
Hip circumference	0.5	1.9	6.0	-1.6	-0.9	1.3	1.5	2.4	-0.6	0.2	0.1	1.6	2.2	0.1
Time employed in main current job	1.4	1.7	4.5	2.1	1.4	0.0	-1.7	0.9	0.3	0.0	1.5	1.1	-2.1	0.6
Alcohol intake versus 10 years previously	0.2	0.3	1.6	0.3	0.2	-0.3	0.2	-0.1	-0.9	-0.9	-0.2	1.3	-0.2	-0.3
Father’s age at death	0.4	0.6	1.7	-0.4	0.4	0.8	-0.1	-1.1	-0.0	0.7	-0.3	-1.3	0.2	1.3
Worrier / anxious feelings	0.5	0.9	3.2	-0.2	-0.1	-1.4	0.3	1.6	1.8	-1.0	0.0	0.1	-0.5	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.2	-0.5	-1.2	-0.6	1.4	1.0	0.6	-0.7	-0.1	1.0	1.5	-1.1
Falls in the last year	0.4	0.5	3.7	-0.2	0.1	0.1	0.9	1.9	0.8	-0.8	0.3	-0.0	0.1	-0.2
Hair/balding pattern: Pattern 3	0.9	1.4	2.8	-1.5	-1.2	0.4	1.0	-0.9	-1.6	-0.5	-1.4	-1.7	1.1	-0.8
Number of live births	0.2	0.3	0.9	-0.5	-1.0	-0.2	0.4	-0.6	-0.0	-0.2	-0.7	0.4	0.8	-0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	-0.9	-0.9	-0.2	-0.1	-1.3	-1.3	-0.2	-0.8	-0.5	0.3	-0.4
Pulse rate	0.6	0.9	4.0	-1.0	-0.6	-0.9	1.0	2.0	0.6	0.1	-0.7	1.3	0.2	-0.9
Happiness	0.6	0.8	2.2	0.5	1.2	-0.8	-1.5	0.6	-0.3	0.7	0.4	0.3	-1.4	0.9
Noisy workplace	0.2	0.3	1.6	-0.5	-0.4	-0.2	-0.1	-1.3	0.5	-0.6	-0.1	0.1	0.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.3	-1.1	-0.8	-1.0	0.6	-0.4	-0.1	-0.8	-1.1	-0.9	0.5	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	0.1	0.3	-0.1	-0.6	-0.4	0.2	-0.2	-0.1	-0.5	-0.7	0.5
Mouth/teeth dental problems: Dentures	1.4	2.4	6.0	1.6	1.2	1.6	-1.4	0.4	-1.5	0.8	2.0	2.5	-0.7	2.0
Asthma	0.6	1.1	2.3	-1.2	-1.2	-1.4	1.2	-1.0	0.4	0.6	-1.5	-0.5	1.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.7	0.2	-0.1	-1.6	0.5	-1.2	1.6	0.7	-0.4	1.2	0.5	-0.2
Medication: Cholesterol lowering	0.1	0.2	1.1	1.1	0.3	0.0	-0.1	0.8	-0.1	-0.3	0.5	-0.5	-0.3	0.0
Depression (self-reported)	0.2	0.2	1.7	0.0	-0.0	-0.1	0.1	-0.2	-1.3	0.6	0.1	0.1	0.3	0.7
Medication: Lansoprazole	1.8	2.1	6.5	1.9	1.7	-1.3	-1.7	0.8	-0.1	1.2	0.6	1.6	-2.5	0.3
Prospective memory result	0.4	0.5	3.5	0.3	-0.3	0.2	-0.1	-0.0	-0.1	1.2	0.3	1.9	0.3	-0.1
Lung cancer (father)	0.6	0.7	2.2	0.3	0.3	0.4	0.2	1.3	1.5	-0.3	1.0	-1.3	-0.5	0.1
Illnesses of mother	3.1	3.8	7.7	-2.3	-2.4	0.7	2.8	-1.6	-0.2	-1.9	-1.8	-2.1	2.8	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.9	-0.1	-0.1	0.4	-0.4	-0.1	-0.9	0.9	-0.1	-0.3	-0.0	0.6
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	1.0	-0.1	1.1	0.1	0.1	-0.8	-0.1	0.9	0.9	-0.2	-0.0
Impedance of arm (left)	0.6	2.7	5.4	-2.3	-1.7	-1.6	1.9	1.4	1.7	-0.1	-1.9	1.0	1.6	-1.8
Arm fat mass (right)	0.5	2.2	8.6	-1.5	-1.0	-0.1	1.6	2.9	0.3	0.6	-0.2	2.4	1.9	-0.6
Trunk predicted mass	0.1	0.7	3.5	-0.8	0.3	1.3	-0.1	-0.2	-1.9	-0.2	0.3	-0.3	0.5	1.0
Standing height	0.3	2.8	12.1	-3.5	-1.5	0.6	1.6	0.6	-1.5	-1.6	-1.7	-0.6	2.1	-0.8
Length of working week for main job	0.7	0.7	2.5	0.4	0.4	1.1	-0.5	-1.3	-1.6	0.1	0.6	0.2	-0.7	1.1
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.1	0.3	-0.2	-0.2	0.3	-0.2	-0.7	0.0	0.5	-0.2	-0.3
Breastfed as a baby	0.3	0.3	2.3	-0.3	-0.4	-0.2	-0.1	-1.5	-0.5	0.2	-0.5	-0.7	0.3	-0.3
Tense / ‘highly strung’	1.7	2.9	5.7	1.4	1.9	0.9	-1.4	2.0	0.5	1.7	2.4	1.7	-1.6	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.5	0.1	-0.3	-0.8	0.2	0.4	0.3	0.5	0.4	1.2	0.1	-0.1
Hair/balding pattern: Pattern 4	0.6	1.4	3.0	1.1	1.4	-0.5	-1.7	0.6	0.3	1.3	1.1	1.7	-1.0	1.2
Birth weight of first child	1.3	2.3	4.8	-2.2	-1.7	-0.6	1.5	-1.0	-0.2	-1.6	-2.1	-1.6	1.6	-1.4
Peak expiratory flow (PEF)	0.3	0.6	2.1	0.7	0.1	0.1	-1.0	-1.5	-0.3	0.5	0.1	-1.1	-1.2	0.2
Pulse wave reflection index	1.8	2.3	5.2	2.3	1.1	2.1	-1.4	-1.8	-1.3	0.7	1.8	-0.2	-0.8	1.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.3	-0.6	-0.3	-1.1	0.1	-0.1	-0.1	0.1	-0.7	0.6	0.2	-0.5
Loud music exposure frequency	0.3	0.3	1.5	0.2	0.3	0.6	-0.7	0.4	-0.5	0.3	0.7	1.2	-0.4	0.3
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.4	-0.6	0.5	-0.7	-0.7	-1.1	-1.6	-0.8	-1.3	-1.4	-0.7	0.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.3	-0.9	-0.7	0.0	1.1	1.7	-0.6	1.6	-0.1	2.1	1.2	0.1
Blood clot in the leg (DVT)	0.1	0.2	1.0	-0.0	-0.2	-0.0	0.4	0.2	1.0	-0.4	-0.3	0.7	-0.1	-0.4
Medication: Paracetamol	0.2	0.3	1.5	1.2	0.4	-0.3	0.0	-0.8	-0.2	0.8	0.2	0.2	-0.4	0.6
Headache pain in last month	0.3	0.5	0.9	0.3	-0.4	-0.7	1.0	-0.9	0.4	0.9	-0.9	0.7	0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	2.0	-0.4	0.3	-0.2	-0.5	-1.4	0.1	0.2	-0.3	0.1	-0.3	0.3
Glaucoma (self-reported)	0.3	0.3	1.2	1.1	0.5	-0.4	0.3	0.1	0.7	0.7	0.5	0.7	-0.4	0.2
Gout (self-reported)	0.5	0.7	3.0	0.0	0.5	0.8	-0.1	0.4	-1.3	-1.7	0.0	-1.3	0.1	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.1	-0.2	-0.7	-0.2	0.7	1.0	0.8	0.0	-0.0	0.4	0.5	-0.5
Medication: Amlodipine	0.5	0.7	3.4	-0.2	-0.2	1.3	0.6	0.5	-1.8	-1.2	-0.4	-0.2	0.5	0.2
Medication: Ventolin 100micrograms inhaler	2.0	2.5	4.7	-1.9	-1.8	-2.2	1.3	-1.8	1.8	0.6	-1.9	-0.8	1.1	-1.5
Birth weight	1.7	3.6	7.7	-2.3	-2.4	-1.1	0.6	-2.8	-0.5	-2.2	-2.4	-1.5	1.6	-2.0
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.2	-1.5	-0.9	-2.1	1.0	-0.2	0.8	-0.2	-1.8	-0.5	1.2	-1.0
High blood pressure (siblings)	0.7	1.0	2.2	1.5	1.2	1.0	-1.4	0.8	-0.4	-0.4	1.1	0.4	-1.3	0.5
Forced vital capacity (FVC), Best measure	0.1	0.4	2.2	-0.5	-0.3	0.7	-0.1	-0.3	-1.5	0.4	-0.3	-0.7	0.3	0.6
Body fat percentage	1.0	4.0	9.1	-2.4	-2.1	-0.3	2.6	3.0	0.4	0.1	-1.2	2.2	2.9	-1.7
Leg fat percentage (right)	0.5	1.9	4.3	-1.4	-1.3	-0.2	1.7	2.0	0.0	0.4	-0.7	2.0	2.1	-0.9
Arm fat-free mass (right)	0.1	0.7	3.1	-0.9	-0.0	1.1	0.0	0.6	-1.8	0.5	0.3	0.6	0.7	0.8
Exposure to tobacco smoke outside home	0.4	0.5	2.8	0.1	0.5	0.9	0.6	1.7	-0.1	0.0	0.7	0.1	0.2	0.8
Comparative body size at age 10	0.6	1.6	3.6	1.1	1.6	0.6	-1.9	0.9	-0.8	1.2	1.2	0.2	-1.4	1.9
Number of full brothers	0.5	0.7	5.3	-0.2	-0.6	-0.2	-0.1	-2.3	0.4	1.1	-0.0	0.3	0.4	0.0
Worry too long after embarrassment	0.3	0.5	3.3	-0.6	-0.3	-0.4	0.3	1.8	0.8	0.6	0.8	0.3	0.0	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.7	0.6	0.6	0.1	-0.1	1.3	-1.8	1.2	0.7	1.9	-0.0	0.7
Wheeze or whistling in the chest in last year	0.6	1.0	2.7	-1.4	-0.7	-1.6	1.2	0.6	1.5	0.5	-1.0	0.0	0.7	-0.4
Number of children fathered	0.7	0.8	3.0	0.3	0.3	-0.0	-0.9	-0.3	-0.6	1.7	0.7	1.7	-0.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	3.6	0.0	-0.2	-0.5	0.8	1.9	1.1	-0.3	-0.2	0.6	0.2	-1.1
Age at first live birth	0.2	0.3	1.7	-0.2	0.2	1.3	-0.4	-0.4	-0.1	0.3	0.2	-0.5	0.5	0.7
Pulse wave peak to peak time	0.3	0.4	1.3	-1.1	0.1	-0.8	-0.1	-0.0	0.7	0.0	-0.9	-1.0	0.3	0.1
Health satisfaction	1.8	2.4	11.4	0.0	0.9	-1.9	-0.7	3.4	0.9	1.5	0.2	2.3	-1.2	0.1
Shortness of breath walking on level ground	3.1	3.7	5.7	-2.2	-2.3	-2.2	2.1	0.7	1.6	0.3	-1.9	1.8	2.3	-2.4
Qualifications: College or University degree	0.1	0.2	1.1	0.2	0.2	-1.0	0.1	-0.1	0.7	-0.3	-0.2	0.2	-0.2	-0.3
Eye problems/disorders: None of the above	0.3	0.3	1.1	-0.8	-0.5	0.2	0.5	0.7	0.1	-1.1	-0.4	0.1	0.6	-0.6
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.5	1.2	0.9	1.0	-0.9	-0.1	-1.2	0.0	1.0	-1.6	-1.1	1.2
Emphysema/chronic bronchitis	0.2	0.2	1.2	0.2	-0.1	-0.6	-0.2	0.7	-0.4	0.6	-0.1	1.1	-0.2	-0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	2.6	-1.6	-0.3	1.0	-0.3	0.3	-1.2	0.5	-0.5	-0.1	0.4	0.2
Neck or shoulder pain in last month	0.7	1.1	5.1	0.1	-0.2	-0.8	0.9	0.9	1.5	1.2	0.0	2.3	0.8	-0.2
Medication: Blood pressure	0.2	0.3	1.2	0.6	0.4	0.2	-0.3	1.1	-0.4	0.4	0.3	-0.4	-0.5	0.6
Angina (self-reported)	0.5	0.6	1.4	0.5	0.8	1.2	-0.5	0.6	-0.8	-0.9	1.1	-0.6	-0.4	0.7
Migraine (self-reported)	1.1	1.4	2.9	-0.9	-1.4	-1.4	1.7	-1.0	0.9	-0.7	-1.3	-0.8	1.3	-1.2
Medication: Ibuprofen	0.8	1.0	4.0	-0.1	-0.2	-2.0	0.8	-0.8	1.9	0.7	-0.7	0.6	0.6	-0.2
Medication: Allopurinol	0.2	0.2	1.5	0.2	0.5	0.2	-0.4	0.5	-0.4	-1.2	0.3	-0.1	-0.4	0.2
Medication: Omeprazole	0.5	0.6	1.7	-0.9	-0.5	-0.0	0.9	1.3	1.1	-0.3	0.3	0.8	0.6	-0.1
Medication: Seretide 50 evohaler	0.8	0.9	3.6	-0.4	-0.8	-0.0	1.9	1.0	1.2	0.8	0.1	-0.5	1.4	-0.3
Mean time to correctly identify matches	1.0	2.0	7.6	2.8	2.0	0.1	-0.9	1.3	1.3	-0.4	1.9	0.2	-1.6	0.5
Heart disease (mother)	1.3	1.6	4.5	0.8	1.0	-1.5	-1.3	1.6	2.1	0.9	0.5	1.1	-1.7	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	4.9	-1.1	-0.8	-2.2	1.1	-0.6	2.1	0.1	-1.3	-0.7	0.4	-1.0
Whole body fat mass	0.8	3.4	8.6	-2.5	-1.8	-0.1	2.3	2.9	0.0	0.4	-1.0	2.2	2.7	-1.2
Leg fat mass (right)	0.6	2.2	6.2	-1.8	-1.2	0.1	1.7	2.5	-0.4	0.3	-0.5	2.1	2.2	-0.7
Arm predicted mass (right)	0.1	0.8	3.4	-0.6	0.3	1.2	-0.1	0.8	-1.8	0.6	0.6	0.6	0.5	1.1
Pulse rate, automated reading	0.4	1.3	7.1	0.4	0.8	1.0	-0.3	2.7	-0.6	0.5	0.9	1.6	-0.6	0.5
Alcohol intake frequency.	0.4	0.8	3.8	0.3	0.1	1.9	-0.5	-0.0	-1.4	-0.2	0.7	1.4	0.2	0.6
Comparative height size at age 10	0.2	1.2	3.6	-1.1	1.0	1.1	-0.1	1.5	-1.0	-1.9	0.0	-1.6	0.2	0.6
Number of full sisters	0.3	0.4	0.9	0.9	0.4	0.3	-0.9	-0.4	-0.6	-0.9	0.5	0.1	-0.8	0.2
Suffer from ‘nerves’	0.5	0.7	1.9	1.0	0.8	0.3	-1.3	0.0	-0.3	0.2	1.2	-0.3	-1.4	1.0
Overall health rating	1.0	2.2	6.5	-0.8	-1.6	-0.4	2.1	1.8	-0.7	-0.1	-0.5	2.6	1.9	-1.3
Chest pain or discomfort	2.2	3.1	10.6	-1.1	-2.3	-1.3	1.9	0.5	1.2	1.6	-0.6	3.3	2.1	-1.7
Had major operations	0.7	0.9	2.0	-1.4	-1.1	-0.8	1.1	-0.2	0.9	-0.8	-1.1	-0.6	0.8	-0.8
Age at last live birth	0.4	0.5	2.0	-0.3	0.5	1.4	-0.7	0.6	0.6	0.6	0.9	0.7	0.3	0.8
Family relationship satisfaction	1.5	1.8	5.5	0.7	2.2	-0.8	-1.8	1.9	-0.2	-0.2	0.5	-0.6	-2.3	0.9
Leg pain on walking	0.3	0.3	1.0	-0.2	-0.3	-0.5	0.2	-0.2	-0.8	-0.9	-1.0	-0.6	-0.0	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	-1.0	-1.3	-0.2	1.1	-0.3	0.5	0.1	-0.7	-0.1	0.9	-1.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	6.6	2.6	1.9	0.0	-1.3	0.3	-0.2	0.1	1.2	-0.3	-2.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	0.4	-0.1	-0.3	0.5	0.1	0.6	-0.6	-0.5	0.1	0.5	-0.8
Medication: Aspirin	1.0	1.3	3.3	1.6	1.4	0.2	-0.7	1.8	0.6	-1.1	1.5	0.6	-1.5	0.4
Supplements: Vitamin C	1.1	1.3	3.3	1.5	0.8	-0.8	-1.7	-1.8	0.0	0.7	0.1	-1.1	-1.7	0.3
Knee pain experienced in last month	0.1	0.2	0.8	0.3	-0.2	0.7	0.9	0.0	-0.2	-0.4	0.2	-0.3	0.5	0.1
Hypertension (Self-reported)	0.4	1.2	4.1	1.5	0.9	-0.2	0.1	2.0	0.4	1.2	0.9	1.5	-1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.7	1.5	1.5	-0.1	-1.0	1.2	0.7	1.1	1.3	0.7	-1.9	1.3
Illnesses of father: Heart disease	1.4	2.0	5.1	2.2	1.7	0.6	-1.2	0.5	0.0	1.6	1.9	0.9	-1.6	1.5
Illnesses of siblings: Diabetes	0.1	0.2	0.4	-0.5	-0.3	0.2	0.4	-0.6	-0.3	-0.2	-0.5	-0.5	0.6	-0.1
Smoking status: Previous	1.0	1.5	3.2	-1.8	-1.4	-1.1	1.7	0.0	0.2	0.4	-1.7	0.3	1.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	6.3	-2.3	-2.0	-1.7	2.5	0.9	0.9	0.1	-1.9	0.8	1.9	-2.0
Whole body fat-free mass	0.1	0.8	3.3	-1.0	0.1	1.1	0.2	0.9	-1.8	0.3	0.3	0.8	0.7	0.8
Leg fat-free mass (right)	0.2	1.3	5.9	-1.0	0.1	1.1	0.4	2.4	-1.3	0.5	0.7	1.5	0.8	0.7
Arm fat percentage (left)	0.6	2.5	8.4	-1.4	-1.2	-0.6	1.8	2.9	0.9	0.9	-0.5	2.4	1.9	-1.0
Average weekly red wine intake	0.1	0.2	1.3	-0.3	-0.2	-0.1	-0.1	-0.1	0.4	1.1	-0.1	-0.3	-0.1	0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.7	0.7	0.9	-0.7	-1.0	-0.1	0.0	-0.4	0.3	0.5	-1.3	-0.1
Mood swings	0.8	1.5	5.3	1.0	0.7	0.1	0.8	2.3	-0.2	1.0	1.3	2.3	0.0	1.0
Loneliness, isolation	1.2	1.7	6.7	-0.2	-0.5	-1.6	1.0	1.9	1.3	1.4	0.2	2.6	0.7	-0.9
Long-standing illness, disability or infirmity	0.4	0.6	2.6	0.7	-0.4	-1.6	0.4	0.5	0.6	0.2	-0.4	1.4	0.2	-0.9
Ever had bowel cancer screening	0.5	0.6	1.4	-0.6	-0.8	-0.5	0.9	0.0	1.2	-0.6	-0.5	1.1	0.8	-0.8
Diabetes diagnosed by doctor	0.1	0.2	0.8	0.5	-0.1	-0.6	-0.0	0.5	0.5	-0.4	0.0	0.9	0.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	0.2	-0.1	-1.0	-0.0	-1.1	0.2	0.7	-0.2	-0.2	-0.7	-0.4
Friendships satisfaction	1.1	1.3	5.9	0.5	0.8	0.2	-0.7	-0.5	-0.7	-2.3	-0.2	-2.4	-1.0	0.1
Qualifications: nursing, teaching	0.2	0.3	2.2	0.1	0.2	-1.5	-0.1	-0.1	0.4	0.8	-0.1	0.2	-0.7	0.0
Commuting to job workplace: Walk	2.4	2.5	5.4	-2.2	-2.3	-1.3	1.8	-1.0	0.8	-0.8	-1.9	-0.5	2.0	-1.5
Eye problems/disorders: Cataract	0.2	0.3	0.8	-0.5	-0.1	0.0	-0.1	-0.8	-0.4	0.7	-0.8	-0.9	0.1	0.3
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	4.2	1.7	2.0	1.2	-1.8	1.7	-0.3	-0.3	1.8	0.9	-1.7	1.3
Medication for cholesterol	0.4	0.5	2.9	-1.7	-1.0	0.4	0.1	-0.1	0.7	0.1	-0.1	-0.4	1.0	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	3.1	0.4	-0.3	0.2	0.5	-0.6	0.5	-0.6	-0.0	-1.8	0.8	-0.1
Back pain experienced in last month	0.7	1.0	7.3	0.4	-0.2	-0.3	-0.1	-0.3	0.4	1.7	0.5	2.7	0.4	0.2
Mineral and other dietary supplements	0.3	0.5	2.8	0.2	0.4	-1.0	-0.6	-0.4	-0.1	0.7	0.1	1.7	-0.0	0.0
Breast cancer (self-reported)	0.9	1.1	2.8	0.7	1.0	1.1	-0.8	1.6	-0.5	1.4	1.7	0.4	-0.4	1.2
Asthma (self-reported)	0.6	1.3	2.4	-1.2	-1.3	-1.6	1.3	-1.0	0.5	0.8	-1.5	-0.0	1.1	-1.1
Osteoporosis (self-reported)	1.1	1.4	4.9	-1.4	-0.7	-2.2	0.4	0.1	1.9	-0.7	-1.3	0.6	0.4	-1.3
Osteoarthritis (self-reported)	0.4	0.5	1.6	-0.4	-0.2	-1.0	0.6	-0.0	0.1	-0.8	-1.1	-1.3	0.4	-0.7
Medication: Aspirin	0.9	1.2	2.5	1.4	1.2	0.2	-0.8	1.6	0.7	-1.1	1.4	0.4	-1.4	0.4
Medication: Gliclazide	0.8	0.9	2.5	-0.8	-0.8	-1.0	0.6	1.4	1.2	0.3	-0.5	1.6	0.7	-0.9
Illnesses of father: None of the above (group 1)	3.6	4.5	8.4	-2.9	-2.5	-1.6	2.8	0.7	1.3	-2.0	-2.4	-0.9	2.3	-2.5
Smoking status: Current	0.2	0.4	1.2	0.7	0.7	0.6	-0.1	-0.2	-0.8	0.5	0.7	-0.0	-0.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.7	0.2	-0.7	0.8	0.5	-0.3	-0.7	-0.4	-0.0	-0.5	0.8	-0.1
Whole body water mass	0.1	0.7	2.8	-1.0	0.1	1.0	0.2	0.7	-1.7	0.2	0.3	0.6	0.8	0.8
Leg predicted mass (right)	0.3	1.3	6.0	-1.0	0.1	1.1	0.4	2.5	-1.4	0.5	0.7	1.6	0.8	0.7
Arm fat mass (left)	0.5	2.0	7.9	-1.2	-0.9	-0.1	1.5	2.8	0.3	0.9	-0.0	2.4	1.7	-0.5
Number of self-reported non-cancer illnesses	1.1	1.9	6.5	2.2	1.2	-0.5	-0.4	2.5	0.8	0.0	1.5	1.7	-1.4	0.1
Average weekly champagne plus white wine intake	0.6	0.8	2.3	-0.7	-1.4	-0.4	0.9	-1.5	-0.2	-0.7	-0.6	0.3	1.1	-1.0
Miserableness	0.9	1.6	9.7	0.3	0.0	-0.4	0.7	2.0	-0.1	1.5	1.0	3.1	0.4	0.3
Guilty feelings	0.3	0.5	1.1	0.4	0.7	-0.6	-0.5	1.0	0.5	0.8	0.4	0.6	-0.9	0.7
Wears glasses or contact lenses	0.5	0.6	1.8	0.3	0.8	-0.5	-1.4	-0.6	1.0	-0.7	0.7	-0.4	-1.1	0.5
Ever taken oral contraceptive pill	0.4	0.4	1.8	-0.1	-1.1	0.1	0.2	-1.3	-0.3	0.4	-0.4	0.8	0.6	-0.3
Hearing aid user	1.6	1.8	3.4	-0.9	-1.5	-1.4	1.3	-1.2	1.8	-1.3	-1.5	-0.9	1.0	-1.8
Mother’s age at death	2.5	3.1	7.9	-1.8	-2.0	-0.3	1.2	-2.8	-1.5	-1.1	-2.5	-1.6	1.7	-1.6
Financial situation satisfaction	1.0	1.2	2.4	1.1	1.2	0.4	-1.4	1.0	-0.4	1.5	1.1	0.6	-1.1	1.6
Tinnitus: Yes, now most or all of the time	1.8	2.1	6.7	2.6	1.8	1.8	-1.6	0.7	-0.3	-0.3	1.9	0.1	-1.3	1.4
Commuting to job workplace: Public transport	0.5	0.7	2.8	0.2	0.1	-0.2	-0.7	0.9	0.4	1.7	0.8	1.4	-0.4	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	2.2	0.2	-0.7	-0.2	1.1	-1.5	0.8	-0.3	-0.5	-0.4	0.6	-0.5
Medication: Blood pressure	0.9	1.7	4.7	2.0	1.3	1.0	-0.7	1.7	-1.2	0.1	1.4	2.2	-1.0	0.6
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.8	-1.0	-2.1	-1.0	2.2	1.2	1.8	0.2	-0.7	1.4	1.8	-2.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.4	0.8	0.3	1.3	0.1	0.3	0.3	-1.1	0.5	-1.8	-0.7	0.3
High cholesterol (Self-reported)	0.5	0.9	2.2	1.5	1.4	0.7	-0.5	0.6	-1.2	0.1	0.6	-0.9	-0.8	1.1
Medication: Bendroflumethiazide	0.3	0.4	2.6	0.2	0.3	-1.0	-0.1	0.4	-0.1	1.6	-0.4	0.7	-0.5	0.3
Medication: Paracetamol	0.1	0.2	0.6	0.6	-0.0	-0.3	0.7	-0.5	-0.0	0.8	-0.1	0.2	0.2	0.4
Medication: Lisinopril	1.4	1.8	6.4	-0.9	-2.0	-1.6	0.7	-1.1	0.3	-0.7	-1.6	0.6	0.9	-2.5
Medication: Atorvastatin	1.0	1.2	4.0	-0.7	-1.4	-2.0	1.2	-0.6	0.6	0.4	-1.3	-0.1	1.1	-1.4
Illnesses of father: High blood pressure	1.3	1.6	4.7	1.5	1.0	0.9	-1.4	0.2	-0.6	2.2	1.4	0.8	-1.4	1.2
Alcohol drinker status: Never	0.3	0.3	1.2	-0.2	0.0	1.0	-0.2	0.9	0.4	-0.5	0.5	1.1	0.4	0.2
Ever smoked	0.2	0.3	1.2	-0.2	0.3	-1.0	0.1	-1.1	-0.3	0.0	-0.8	-0.5	-0.0	0.2
Basal metabolic rate	0.2	0.9	2.1	-1.4	-0.3	0.8	0.7	1.4	-1.4	0.2	0.0	1.1	1.2	0.4
Leg fat percentage (left)	0.5	1.8	4.4	-1.3	-1.4	-0.0	1.7	2.1	0.1	0.1	-0.5	1.6	2.1	-1.1
Arm fat-free mass (left)	0.1	0.6	2.1	-0.8	0.3	1.1	0.0	0.9	-1.5	0.3	0.5	0.5	0.6	0.9
Number of operations (self-reported)	0.3	0.5	2.9	-0.1	0.3	-0.8	-0.2	0.3	1.7	1.3	0.2	0.2	-0.1	0.2
Average weekly beer plus cider intake	1.9	2.7	7.3	-1.6	-1.6	-0.8	2.5	1.0	-0.1	0.1	-1.1	2.5	2.7	-1.6
Irritability	0.6	1.0	2.5	-1.6	-1.4	-0.2	1.3	-0.9	-0.5	-0.6	-0.8	-0.6	1.4	-0.7
Risk taking	1.5	2.2	9.7	0.8	1.1	0.7	-0.5	2.2	-0.4	1.8	1.6	3.1	-0.4	1.0
Ever had prostate specific antigen (PSA) test	1.5	1.7	8.0	0.5	0.7	1.7	-0.6	-1.1	-2.8	-1.9	-0.4	-1.4	-0.0	0.3
Fractured/broken bones in last 5 years	0.8	1.0	2.5	0.8	0.9	1.1	-0.7	0.8	-0.6	0.9	1.6	1.1	-0.3	1.5
Age started oral contraceptive pill	1.8	2.2	6.2	1.5	1.0	2.0	-1.3	1.2	-0.4	0.7	2.5	2.1	-0.3	1.6
Diastolic blood pressure, automated reading	0.5	1.6	7.0	0.3	0.5	1.2	-0.1	2.7	0.7	1.2	1.8	1.8	-0.0	0.4
Ever depressed for a whole week	0.8	1.0	3.8	-0.2	0.2	-1.1	-0.1	2.0	1.5	0.5	0.1	2.0	-0.2	-0.2
Unable to work because of sickness or disability	0.3	0.4	0.9	0.8	-0.5	0.9	0.9	-0.1	-0.2	-0.9	0.5	-0.7	0.6	-0.2
Commuting to job workplace: Cycle	0.7	0.9	1.8	-1.1	-0.7	0.2	1.1	0.1	1.3	-1.2	-0.5	-1.3	0.9	-0.5
Myopia	1.9	2.7	6.6	1.7	1.9	1.7	-1.4	2.0	0.5	1.0	2.6	0.4	-1.5	1.9
Vascular/heart problems diagnosed by doctor	0.4	1.1	5.6	-1.1	-0.0	0.7	-0.9	-2.4	-0.9	-0.4	-0.5	-1.5	0.2	0.8
Cholesterol lowering medication	0.2	0.3	0.9	1.0	0.9	-0.1	0.3	-0.4	-0.4	-0.3	-0.1	-0.8	-0.4	0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	-1.2	-1.0	0.4	1.6	1.4	0.6	-1.0	-0.0	0.7	1.4	-0.6
Pain experienced in last month	0.4	0.6	3.5	-1.1	-0.5	0.5	-0.2	0.0	-0.2	-1.1	-0.4	-1.9	0.1	-0.4
Supplements: Calcium	0.5	0.5	2.0	0.0	-0.8	-0.2	0.3	-1.3	0.4	0.8	-0.2	1.4	0.5	-0.6
Basal cell carcinoma (self-reported)	0.4	0.5	2.3	0.1	0.0	0.4	0.2	-0.8	-1.5	0.7	-0.5	0.8	0.2	0.7
Heart attack/myocardial infarction (self-reported)	2.4	3.1	7.0	-0.8	-2.4	-2.4	2.2	-0.9	0.9	-1.5	-1.7	-0.9	1.8	-2.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.6	-0.1	-0.3	0.2	0.5	0.1	0.8	-0.4	-0.3	0.7	0.1	-0.3
Heart disease (siblings)	0.3	0.3	0.8	0.6	0.5	-0.9	-0.2	0.4	0.8	0.5	0.2	0.7	-0.6	0.1
Alcohol drinker status: Previous	0.4	0.4	1.8	0.2	-0.0	0.8	0.4	1.3	-0.8	0.4	0.7	0.7	0.4	0.2
Pack years of smoking	1.3	1.8	3.6	1.9	1.8	1.2	-1.2	0.0	-1.8	0.1	1.4	0.6	-1.1	1.9
Impedance of whole body	0.5	2.3	5.6	-2.4	-1.9	-1.1	1.7	0.5	1.3	-0.7	-2.1	-0.0	1.6	-1.8
Leg fat mass (left)	0.6	2.3	7.5	-1.9	-1.3	0.1	1.8	2.7	-0.2	0.4	-0.5	2.0	2.2	-0.8
Arm predicted mass (left)	0.1	0.6	2.3	-1.1	-0.0	0.9	0.3	0.8	-1.5	-0.2	0.1	0.2	0.9	0.4