Hub : Genes

ZNF680

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1130 0.0340 7.9e-12 0.116 0.120 0.118 0.120 0.108 5.9e-14 2.2e-14 3.2e-14 1.9e-14 4.7e-13
2 GTEx Brain Caudate basal ganglia 0.2700 0.0940 4.7e-04 0.061 NA 0.075 NA 0.083 7.9e-03 NA 3.4e-03 NA 2.2e-03
3 GTEx Brain Frontal Cortex BA9 0.2501 0.1099 2.5e-03 0.025 NA 0.018 NA 0.055 7.2e-02 NA 1.1e-01 NA 1.4e-02
4 GTEx Cells EBV-transformed lymphocytes 0.2690 0.0750 6.2e-05 0.148 NA 0.117 NA 0.135 1.5e-05 NA 1.2e-04 NA 3.7e-05
5 GTEx Esophagus Mucosa 0.1260 0.0570 1.5e-03 0.024 NA 0.059 NA 0.019 9.3e-03 NA 8.1e-05 NA 1.9e-02
6 GTEx Esophagus Muscularis 0.0950 0.0380 1.6e-04 0.045 NA 0.051 NA 0.049 9.3e-04 NA 4.6e-04 NA 5.7e-04
7 METSIM Adipose 0.0685 0.0261 3.1e-04 0.036 0.027 0.038 0.030 0.036 3.9e-06 6.0e-05 2.2e-06 1.9e-05 3.9e-06
8 ROSMAP Brain Pre-frontal Cortex 0.1527 0.0384 0.0e+00 0.175 0.180 0.175 0.185 0.171 6.5e-22 1.5e-22 5.9e-22 3.3e-23 2.1e-21
9 YFS Blood 0.0321 0.0145 2.8e-03 -0.001 0.007 0.003 0.007 0.002 5.9e-01 2.1e-03 2.8e-02 1.4e-03 6.2e-02
10 TCGA Kidney Renal Clear Cell Carcinoma 0.0275 0.0187 7.7e-03 0.011 0.002 0.007 NA 0.003 1.7e-02 1.7e-01 4.8e-02 NA 1.3e-01
11 TCGA Brain Lower Grade Glioma 0.0693 0.0491 7.6e-04 0.026 0.012 0.001 NA 0.013 5.1e-04 1.4e-02 2.4e-01 NA 1.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 1.0 1.6 5.2 0.6 0.6 -1.2 -1.6 -1.2 -0.8 2.3 -0.3 1.5 -1.4 0.7
Bipolar Disorder or Schizophrenia 0.7 1.6 4.8 1.1 1.0 -0.5 -2.2 -0.6 -0.4 1.8 0.4 1.4 -1.9 0.9
Depressed Affect (Nagel 2018) 0.7 1.4 9.5 0.6 -0.2 -0.3 0.9 1.4 -1.0 0.8 0.7 3.1 0.7 -0.3
Depression (Nagel 2018) 0.6 0.8 4.5 0.5 0.4 -0.3 0.1 1.8 0.2 0.3 0.8 2.1 -0.2 0.0
Intelligence (Savage-Jansen 2018) 0.5 1.4 3.3 -1.2 -0.9 1.3 1.3 -0.5 -1.8 -0.6 -1.1 -1.3 1.8 0.2
Neuroticism (Nagel 2018) 0.5 1.1 8.1 0.0 -0.3 -0.4 0.3 1.4 -0.6 0.8 0.7 2.8 0.3 -0.0
Schizophrenia (2018) 0.3 0.7 2.5 0.9 0.8 0.3 -1.6 0.2 0.2 0.5 0.8 0.6 -1.3 0.5
Schizophrenia vs Biploar Disorder 1.3 1.7 4.8 0.9 2.2 0.9 -1.2 1.9 -0.8 0.2 1.1 -0.9 -1.3 1.8
Worry (Nagel 2018) 0.1 0.2 0.6 0.3 0.3 -0.1 -0.6 0.4 -0.4 0.1 0.7 0.7 -0.8 0.4
Alzheimer’s Disease (in mother) 1.9 2.3 4.7 1.3 1.8 1.1 -1.6 1.5 0.7 1.1 2.2 0.7 -1.6 2.2
Alzheimer’s Disease (in father) 2.0 2.2 8.6 0.8 0.4 -1.7 -0.4 1.1 2.4 1.7 0.9 2.9 -0.7 -0.4
Alzheimer’s Disease (including proxy) 1.1 1.6 5.5 0.3 0.1 -1.4 -0.5 1.2 2.3 1.4 0.9 2.4 -0.9 0.1
Crohns Disease (2017) 0.3 0.6 1.3 1.1 0.6 0.4 -0.6 -0.2 -0.5 1.1 0.9 0.7 -0.7 1.0
Irritable Bowel Disease (IBD) 0.1 0.3 1.6 0.3 0.0 0.4 0.4 1.3 0.7 -0.6 0.3 -0.6 -0.1 -0.1
Ulcerative Colitis (UC) 0.6 1.2 3.2 -0.6 -0.7 -0.1 1.3 1.8 1.6 -1.4 -0.5 -1.0 0.4 -1.2
Major Depression (MDD) 0.6 0.7 1.7 -0.8 -1.1 0.2 0.9 1.3 -0.3 0.5 -0.1 1.1 0.8 -0.9
Reaction Time 1.1 2.0 6.9 2.6 1.9 0.3 -1.2 1.1 0.9 0.4 2.0 1.0 -1.6 0.7
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.9 -1.2 -0.8 0.4 1.2 -0.8 -1.1 -1.7 -1.1 -1.4 1.4 -0.1
Breast Cancer 0.3 0.7 2.3 0.4 0.7 0.6 -1.1 1.5 1.3 -0.7 0.9 -0.3 -0.6 0.3
Ovarian Cancer 0.5 0.6 1.7 -1.1 -0.7 -1.1 0.5 0.1 0.2 0.2 -1.3 0.6 0.7 -1.0
Prostate Cancer 0.6 0.8 5.0 0.5 0.8 1.1 -0.6 -0.1 -2.2 -0.2 0.8 0.5 0.0 0.8
Age at First Birth 0.7 1.0 6.1 -0.6 -1.1 -0.9 0.4 -2.5 0.7 0.3 -1.1 -0.6 0.4 -0.5
Bipolar Disorder (2011) 1.3 1.2 2.7 -1.0 -1.4 -1.6 0.9 -0.7 0.0 0.7 -1.6 1.3 0.5 -1.4
Body Mass Index (BMI) (2010) 1.0 1.4 3.8 -0.9 -1.0 -1.9 1.0 0.7 1.1 0.8 -0.9 1.9 0.7 -1.3
Coronary Artery Disease (CAD) 0.7 0.8 2.6 -0.7 -1.1 -1.6 1.2 0.1 1.1 0.1 -0.8 -0.2 0.5 -0.8
Crohns Disease (2012) 0.2 0.3 0.7 0.9 0.4 -0.6 -0.6 -0.3 0.2 0.7 0.6 0.5 -0.8 0.4
Mean Putamen Volume 1.0 1.1 2.4 -0.7 -1.2 -1.1 0.6 -1.6 -1.0 1.1 -1.6 0.5 0.8 -1.0
Fasting Glucose 0.1 0.2 0.5 -0.0 -0.5 0.5 0.3 0.4 -0.1 0.2 0.5 0.7 0.0 -0.3
HbA1C 0.7 0.7 6.3 0.2 -0.2 0.6 0.5 -0.3 -2.5 -0.5 -0.4 0.1 0.8 -0.2
HDL Cholesterol 0.3 0.5 1.4 0.4 -0.6 0.8 0.6 -1.2 0.5 -0.6 0.0 -1.1 0.6 -0.5
LDL Cholesterol 0.9 1.4 4.1 -1.1 -1.7 -0.4 2.0 -0.9 -0.0 -0.4 -1.8 0.1 1.1 -1.3
Lupus 0.5 0.7 1.6 -0.5 -0.9 -0.8 1.3 -0.3 0.3 -0.4 -1.1 1.2 0.7 -1.0
Neuroticism (2016) 0.3 0.4 1.3 -0.3 -0.4 0.4 0.5 0.9 -0.5 -1.1 0.0 -1.1 0.3 -0.5
Primary Biliary Cirrhosis 0.9 1.2 2.5 1.5 1.3 0.5 -1.0 1.6 -1.0 -0.9 0.5 -0.9 -1.6 0.7
Rheumatoid Arthritis 0.4 0.5 2.2 1.1 -0.1 1.5 0.7 0.4 -0.5 0.3 0.7 -0.6 0.4 0.2
Schizophrenia (2014) 0.8 1.7 6.7 1.3 1.5 -0.9 -2.1 -0.2 0.0 1.3 0.7 -0.0 -2.6 1.0
Triglycerides 0.5 0.7 5.6 -0.2 -0.5 0.1 0.2 0.9 -0.6 0.9 0.3 2.4 0.4 -0.1
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.2 1.1 0.9 -0.4 -0.7 -0.2 -1.0 0.8 0.5 1.0 -0.8 1.0
Ulcerative Colitis 0.7 1.0 2.1 -0.8 -1.1 0.3 1.4 -0.2 0.6 -1.4 -0.9 -1.0 1.1 -1.3
Blood Eosinophil Count 0.2 1.9 9.7 0.3 0.7 3.1 -0.3 1.6 -1.3 0.2 1.5 0.8 0.9 1.6
Blood Platelet Count 0.6 6.8 14.2 2.8 3.8 2.8 -2.9 2.0 -0.7 1.4 3.2 -0.3 -2.5 3.7
Blood Red Count 0.0 0.4 1.2 0.3 0.4 0.9 -0.7 -1.1 -0.2 0.9 -0.1 0.3 -0.0 0.8
Blood White Count 0.7 5.0 30.5 0.9 0.9 1.4 0.0 5.5 -0.4 1.9 2.1 3.4 0.6 1.0
Heel T-Score 0.1 0.7 4.8 1.1 0.5 0.6 0.1 -0.5 0.3 -2.2 0.4 -1.0 -0.5 -0.1
BMI 0.3 1.7 4.6 -1.6 -1.4 -0.1 1.8 1.6 -0.4 0.1 -1.1 1.4 2.1 -1.0
Height 0.2 3.0 9.2 -3.0 -0.6 1.6 1.0 0.5 -2.5 -2.5 -1.1 -1.6 1.8 -0.1
Waist Hip Ratio (WHR) 0.3 1.3 3.3 1.4 1.6 -0.7 -1.3 1.2 1.2 0.6 0.7 0.6 -1.8 0.3
Systolic Blood Pressure 0.4 2.0 4.5 1.3 1.8 1.9 -1.3 1.3 0.1 0.7 2.1 0.1 -1.3 1.8
Smoking Status 0.3 0.8 2.8 -0.9 -1.0 0.1 1.3 0.0 -0.7 0.9 -0.5 0.8 1.7 -0.1
Allergy or Eczema 0.2 0.4 1.7 -0.1 0.7 -1.3 0.1 -0.4 0.8 -0.1 -0.8 0.2 -0.6 0.4
Cardiovascular Disease 0.4 1.4 3.6 1.6 1.3 0.0 -0.1 1.9 -0.2 1.6 0.8 1.7 -0.9 0.8
Hypothyroidism (self reported) 0.3 0.6 2.7 0.2 0.1 1.2 0.3 1.6 -0.2 0.5 0.8 0.7 0.6 0.9
Respiratory disease 0.2 0.5 1.1 -0.9 -0.7 -0.8 0.6 -0.2 -0.3 1.1 -0.6 1.0 0.9 -0.3
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.5 0.6 0.5 -0.3 -0.6 0.7 0.5 -0.5 0.5 -0.1 -0.2 -0.1
Lung FEV1/FVC ratio 0.0 0.2 1.1 -0.5 -0.1 0.4 0.1 0.8 -0.0 -1.0 0.1 -0.4 0.3 -0.4
Lung FVC 0.6 3.0 11.4 1.9 0.6 1.5 -1.4 -3.4 -2.0 -1.1 0.7 -2.3 -1.3 1.2
Neuroticism 0.3 0.8 2.3 -0.7 -1.5 -0.4 1.1 0.5 -0.3 -0.3 -0.1 1.4 1.1 -1.1
Chronotype (morning person) 0.2 0.5 1.4 -0.6 -0.8 -0.3 1.1 -0.5 1.2 -0.6 -0.5 -0.3 0.8 -0.6
Hair Pigment 0.1 1.6 3.5 1.8 1.7 0.3 -1.5 1.1 0.8 -1.0 1.7 -0.2 -1.9 0.0
Tanning 0.1 0.8 5.4 -0.9 -0.8 -0.9 -0.5 -2.3 0.2 0.6 -0.8 -0.0 -0.2 -0.3
Hand grip strength (left) 0.5 1.4 5.3 -1.5 -1.7 -0.7 0.5 -2.3 0.1 -0.3 -1.0 -0.3 1.0 -1.5
Number of treatments/medications taken 0.7 1.2 4.3 0.3 -0.7 -2.1 1.8 1.1 0.8 -0.2 -1.1 0.2 0.5 -1.3
Average weekly spirits intake 1.2 1.5 4.6 0.9 1.0 2.1 -0.6 2.0 -1.4 -0.1 1.4 0.2 -0.5 1.0
Sensitivity / hurt feelings 0.6 1.1 5.2 -0.5 -0.2 -1.0 0.4 1.7 0.7 1.4 0.1 2.3 0.4 0.2
Frequency of depressed mood in last 2 weeks 1.0 1.3 2.8 0.6 1.2 0.2 -1.3 1.7 0.5 0.6 1.7 1.4 -1.2 1.2
Hearing difficulty/problems: Yes 0.8 1.2 6.1 -0.2 0.3 -1.4 -0.0 1.4 1.3 1.0 -0.5 2.5 -0.3 -0.4
Relative age of first facial hair 0.2 0.5 1.6 -0.3 -0.5 -1.3 0.7 -1.1 0.5 -0.2 -0.9 -0.0 0.5 -0.4
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 3.1 -1.1 -1.7 -1.8 1.7 0.7 0.1 -0.2 -1.8 0.8 1.5 -1.6
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.6 0.1 0.3 0.2 -0.1 0.3 -0.8 -0.6 0.0 0.1 -0.0 0.0
Ever had hysterectomy (womb removed) 0.7 0.8 3.2 -0.3 -0.4 -0.7 0.5 -0.9 0.7 -1.8 -0.5 -1.5 0.4 -0.8
Systolic blood pressure, automated reading 0.7 2.1 5.8 1.6 1.8 1.9 -1.2 1.6 -0.1 0.2 2.4 0.9 -1.0 1.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.7 0.0 0.1 0.9 -0.2 0.8 -0.4 0.1 0.4 0.6 0.3 0.3
Angina 0.5 0.7 2.2 0.5 0.7 1.5 -0.4 0.8 -1.0 -1.0 1.1 -0.5 -0.2 0.7
Medication for hormone replacement therapy 0.3 0.3 1.1 0.4 0.4 -0.4 -0.1 -0.2 -0.9 -0.7 -0.3 -1.1 -0.8 -0.1
Vitamin and mineral supplements 0.7 1.0 5.0 0.2 0.4 0.7 -0.3 0.2 -0.3 1.7 1.0 2.2 0.4 1.0
Supplements: Zinc 1.1 1.2 3.3 1.4 1.5 0.3 -0.9 1.8 0.2 0.7 1.0 0.6 -1.6 0.7
Medication: Co-codamol 0.7 0.8 3.1 0.4 1.2 -0.1 -1.8 -0.8 -1.0 0.4 0.3 0.2 -1.2 0.9
Medication: Metformin 0.1 0.1 0.5 -0.4 -0.2 -0.2 -0.2 -0.0 0.1 -0.7 -0.2 -0.0 0.1 -0.4
Diabetes (father) 1.3 1.6 4.8 1.3 1.8 0.2 -2.2 -0.4 -1.0 -0.1 0.7 -1.2 -1.9 1.1
Diabetes (mother) 1.1 1.4 5.5 0.9 0.5 -0.9 -0.5 1.4 -0.0 2.4 1.4 1.7 -0.8 0.7
Severe depression (siblings) 0.3 0.3 1.3 -0.1 -0.1 -0.2 0.9 1.0 1.2 0.1 0.3 0.2 0.3 -0.5
Pack years adult smoking proportion 1.0 1.6 3.4 1.6 1.6 1.2 -1.0 0.0 -1.8 0.1 1.3 0.6 -0.9 1.8
Impedance of leg (right) 0.6 3.0 7.5 -2.6 -2.2 -1.3 1.5 -1.8 0.4 -0.7 -2.7 -0.8 1.7 -1.7
Leg fat-free mass (left) 0.3 1.4 5.0 -1.3 -0.2 0.7 0.6 2.2 -1.3 0.9 0.3 2.0 1.0 0.5
Trunk fat percentage 1.3 5.2 12.1 -2.8 -2.4 -0.4 2.8 3.5 0.4 0.1 -1.4 2.7 3.2 -1.9
Hand grip strength (right) 0.2 0.6 3.2 -1.0 -0.6 -0.6 -0.2 -1.8 -0.3 0.3 -0.7 0.3 0.3 -0.6
Townsend deprivation index at recruitment 0.5 0.7 2.0 -0.8 -0.7 0.9 0.6 1.4 -0.4 -0.7 0.4 1.2 1.2 -0.3
Current tobacco smoking 0.2 0.4 1.2 0.7 0.7 0.7 -0.1 -0.1 -0.7 0.4 0.8 -0.2 -0.3 1.1
Average weekly fortified wine intake 1.3 1.6 3.5 -1.4 -1.9 -0.8 1.3 -1.6 1.2 1.0 -1.0 0.6 1.5 -0.9
Maternal smoking around birth 0.3 0.4 1.1 -0.4 -0.3 0.5 -0.0 1.0 0.5 0.3 1.0 0.9 0.7 0.4
Fed-up feelings 0.1 0.2 0.5 0.3 0.1 0.2 0.5 0.7 -0.7 0.3 0.4 0.5 0.4 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 1.9 11.2 0.8 0.8 -0.6 -0.2 3.3 0.4 0.8 1.4 2.2 -0.8 0.6
Relative age voice broke 1.0 1.5 4.8 1.0 1.2 -1.6 -1.4 -2.2 0.2 0.3 -0.5 -1.1 -1.7 0.6
Taking other prescription medications 0.4 0.7 2.6 1.0 0.4 -1.6 0.2 -0.1 0.7 -0.9 -0.3 -1.2 -0.8 -0.4
Age when periods started (menarche) 0.7 1.7 4.5 -2.0 -1.2 -0.7 1.1 -1.4 -1.1 -1.0 -2.1 0.3 1.3 -1.2
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 5.6 -0.6 -0.1 1.2 0.5 -0.1 -0.1 -2.1 -0.6 -2.4 0.6 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 8.8 2.1 2.7 1.4 -2.0 -0.4 -0.1 0.3 1.8 -1.6 -2.4 3.0
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 5.4 0.0 0.7 -1.2 -0.5 2.3 2.0 1.3 0.2 1.8 -1.6 -0.2
Qualifications: CSEs or equivalent 0.3 0.4 2.3 0.3 0.2 -0.1 -0.7 -0.4 0.2 -0.9 -0.1 -1.5 -0.7 -0.0
Serious illness, injury or assault to yourself 1.0 1.2 4.8 0.7 0.8 0.8 -0.7 2.2 -0.2 0.9 1.5 1.2 -0.5 1.1
High blood pressure 0.4 1.1 3.9 1.5 0.6 -0.2 0.1 2.0 0.4 1.2 0.7 1.8 -0.8 0.0
Hayfever, allergic rhinitis or eczema 0.4 0.8 4.7 -0.3 0.1 -2.2 0.3 -0.6 0.9 0.4 -1.3 0.4 -0.4 -0.4
Multivitamins +/- minerals 0.3 0.4 1.5 -0.2 -0.1 -0.6 -0.3 0.0 0.5 -0.9 -0.8 -1.2 -0.7 -0.4
Stomach or abdominal pain in last month 0.3 0.4 1.9 -0.3 -0.6 -0.1 0.4 0.0 0.6 1.1 -0.3 1.4 0.4 -0.4
Supplements: Glucosamine 0.2 0.3 1.5 0.1 -0.0 0.7 -0.2 -0.2 -0.3 0.2 0.4 -1.2 -0.5 0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.0 1.0 0.9 -0.9 0.2 0.3 0.7 0.8 0.7 0.7 -0.5 0.6
Medication: Atenolol 0.3 0.3 0.9 -0.2 -0.1 -0.9 0.3 0.6 0.7 -0.7 -0.6 0.0 -0.1 -0.8
Medication: Levothyroxine sodium 0.1 0.2 0.5 -0.5 -0.7 -0.7 0.6 0.5 0.4 -0.2 -0.6 0.1 0.1 -0.6
Sitting height 0.2 1.7 5.7 -1.4 0.2 2.4 0.5 0.9 -2.2 -0.8 0.2 -1.1 1.3 1.3
Chronic bronchitis/emphysema (father) 0.2 0.3 0.8 0.9 0.6 0.2 0.0 0.1 -0.0 -0.4 0.9 -0.5 -0.5 0.4
High blood pressure (mother) 2.0 2.8 7.5 2.3 2.4 0.2 -1.7 2.5 -0.3 -0.3 1.6 0.7 -2.7 0.7
Body mass index (BMI) 0.2 1.0 4.5 -0.3 -0.4 0.2 0.8 2.1 -0.1 0.7 0.5 2.0 1.1 -0.1
Impedance of leg (left) 0.5 2.6 5.4 -2.3 -2.1 -0.6 1.4 -1.4 0.2 -1.2 -2.3 -1.3 1.7 -1.7
Leg predicted mass (left) 0.3 1.4 5.0 -1.3 -0.2 0.7 0.6 2.2 -1.2 0.8 0.3 2.0 1.0 0.5
Trunk fat mass 0.9 3.9 10.0 -2.6 -1.9 0.1 2.5 3.2 -0.2 0.1 -1.1 2.2 2.9 -1.4
Waist circumference 0.4 1.5 9.4 -0.9 -0.3 -0.0 1.1 3.1 0.2 0.3 0.2 1.9 1.2 -0.3
Number of incorrect matches in round 1.2 2.0 4.0 2.0 1.7 -0.5 -1.6 -0.2 1.1 0.3 1.8 1.6 -2.0 0.7
Past tobacco smoking 0.4 0.8 2.1 1.1 0.7 1.4 -1.1 0.6 -0.1 -0.3 1.4 0.2 -0.9 0.7
Alcohol usually taken with meals 0.4 0.7 2.5 0.0 -0.6 -0.7 0.1 -1.6 0.8 -0.9 -0.6 -1.1 -0.3 -0.8
Nervous feelings 0.9 1.7 3.0 1.0 1.6 1.2 -1.6 1.6 -0.8 -1.1 1.7 0.2 -1.4 1.3
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 8.4 0.3 1.0 -0.5 -1.1 2.9 0.7 0.5 1.3 1.4 -1.4 0.6
Hearing difficulty/problems with background noise 1.8 2.8 12.3 1.3 1.0 -1.0 -0.8 1.7 1.7 2.1 1.5 3.5 -1.2 0.2
Hair/balding pattern: Pattern 2 0.2 0.2 1.1 0.2 -0.0 0.2 0.5 0.2 1.0 -0.8 -0.0 -0.2 0.4 -0.3
Had menopause 0.9 1.2 2.8 1.7 1.3 1.2 -1.4 0.4 -0.1 -0.3 1.4 0.0 -1.1 1.2
Had other major operations 1.4 1.7 3.4 1.3 1.8 0.3 -1.3 1.0 1.1 1.6 1.8 0.6 -1.2 1.4
Forced vital capacity (FVC) 0.2 0.9 4.0 -1.0 -0.8 0.5 0.0 -1.5 -2.0 -0.4 -0.7 -0.8 0.7 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 1.3 3.0 8.9 2.0 2.5 1.7 -1.4 0.1 -0.1 0.2 2.0 -1.4 -1.6 3.0
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 6.1 -1.2 -0.9 -2.5 0.4 1.6 1.9 0.4 -1.4 1.3 0.1 -1.4
Qualifications: None of the above 1.6 3.3 7.3 2.2 1.9 2.0 -1.5 2.6 0.4 1.2 2.7 1.0 -1.4 1.9
Financial difficulties in last 2 years 1.2 1.6 3.8 0.3 0.7 1.6 -1.1 1.9 -0.1 1.1 1.9 1.5 -0.5 1.3
Mouth/teeth dental problems 2.5 3.8 6.7 -2.4 -2.1 -1.2 2.1 -1.3 1.4 -1.4 -2.3 -2.2 1.8 -2.6
Heart attack 2.6 3.3 7.0 -0.8 -2.4 -2.4 2.4 -0.7 1.1 -1.6 -1.6 -0.7 1.9 -2.7
Allergy 0.4 0.8 4.7 0.3 0.0 2.2 -0.3 1.0 -1.0 -0.6 1.4 -0.1 0.3 0.3
Pain all over the body in last month 1.4 1.5 4.5 -0.5 -1.3 -1.9 1.2 -0.3 1.0 -1.5 -1.2 -0.4 0.3 -2.1
Diabetes (self-reported) 0.2 0.3 2.1 0.3 0.4 -0.5 -0.4 1.4 0.3 -0.1 0.3 0.9 -0.1 -0.3
Hayfever/allergic rhinitis (self-reported) 3.7 4.9 11.4 2.4 3.1 1.0 -3.4 -0.3 -0.4 1.2 2.1 -0.2 -3.4 2.9
Medication: Ramipril 0.9 1.1 4.4 1.1 1.0 0.1 -0.6 2.1 1.2 -0.3 1.5 0.6 -1.1 0.6
Medication: Simvastatin 0.8 1.2 3.3 1.2 0.6 1.8 0.3 1.2 -0.4 -1.6 1.0 -1.6 0.1 0.5
Fluid intelligence score 0.5 1.1 2.5 -1.6 -0.8 0.1 1.5 0.4 -0.6 -1.3 -1.0 -0.9 1.6 -0.1
Illnesses of siblings 0.3 0.5 1.5 -0.8 -0.7 -0.6 0.7 -1.2 0.3 0.6 -0.5 -0.7 0.5 0.1
Neuroticism score 0.3 0.6 1.8 -0.2 -0.5 -1.0 0.6 1.2 0.7 0.8 0.4 1.3 0.1 -0.2
Weight 0.3 1.7 5.2 -1.8 -1.0 0.4 1.4 2.3 -0.6 0.1 -0.3 1.8 1.9 -0.4
Impedance of arm (right) 0.5 2.4 5.3 -2.3 -1.5 -1.2 1.7 1.3 1.6 -1.0 -1.8 0.5 1.5 -1.9
Arm fat percentage (right) 0.6 2.4 8.6 -1.4 -1.2 -0.4 1.8 2.9 1.0 0.4 -0.4 2.2 1.9 -1.1
Trunk fat-free mass 0.1 0.7 3.7 -0.8 0.2 1.3 -0.0 -0.2 -1.9 -0.2 0.2 -0.3 0.5 1.0
Hip circumference 0.5 1.9 6.0 -1.6 -0.9 1.3 1.5 2.4 -0.6 0.2 0.1 1.6 2.2 0.1
Time employed in main current job 1.4 1.7 4.5 2.1 1.4 0.0 -1.7 0.9 0.3 0.0 1.5 1.1 -2.1 0.6
Alcohol intake versus 10 years previously 0.2 0.3 1.6 0.3 0.2 -0.3 0.2 -0.1 -0.9 -0.9 -0.2 1.3 -0.2 -0.3
Father’s age at death 0.4 0.6 1.7 -0.4 0.4 0.8 -0.1 -1.1 -0.0 0.7 -0.3 -1.3 0.2 1.3
Worrier / anxious feelings 0.5 0.9 3.2 -0.2 -0.1 -1.4 0.3 1.6 1.8 -1.0 0.0 0.1 -0.5 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 2.2 -0.5 -1.2 -0.6 1.4 1.0 0.6 -0.7 -0.1 1.0 1.5 -1.1
Falls in the last year 0.4 0.5 3.7 -0.2 0.1 0.1 0.9 1.9 0.8 -0.8 0.3 -0.0 0.1 -0.2
Hair/balding pattern: Pattern 3 0.9 1.4 2.8 -1.5 -1.2 0.4 1.0 -0.9 -1.6 -0.5 -1.4 -1.7 1.1 -0.8
Number of live births 0.2 0.3 0.9 -0.5 -1.0 -0.2 0.4 -0.6 -0.0 -0.2 -0.7 0.4 0.8 -0.8
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.6 -0.9 -0.9 -0.2 -0.1 -1.3 -1.3 -0.2 -0.8 -0.5 0.3 -0.4
Pulse rate 0.6 0.9 4.0 -1.0 -0.6 -0.9 1.0 2.0 0.6 0.1 -0.7 1.3 0.2 -0.9
Happiness 0.6 0.8 2.2 0.5 1.2 -0.8 -1.5 0.6 -0.3 0.7 0.4 0.3 -1.4 0.9
Noisy workplace 0.2 0.3 1.6 -0.5 -0.4 -0.2 -0.1 -1.3 0.5 -0.6 -0.1 0.1 0.3 -0.4
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.3 -1.1 -0.8 -1.0 0.6 -0.4 -0.1 -0.8 -1.1 -0.9 0.5 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.5 0.1 0.3 -0.1 -0.6 -0.4 0.2 -0.2 -0.1 -0.5 -0.7 0.5
Mouth/teeth dental problems: Dentures 1.4 2.4 6.0 1.6 1.2 1.6 -1.4 0.4 -1.5 0.8 2.0 2.5 -0.7 2.0
Asthma 0.6 1.1 2.3 -1.2 -1.2 -1.4 1.2 -1.0 0.4 0.6 -1.5 -0.5 1.1 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 2.7 0.2 -0.1 -1.6 0.5 -1.2 1.6 0.7 -0.4 1.2 0.5 -0.2
Medication: Cholesterol lowering 0.1 0.2 1.1 1.1 0.3 0.0 -0.1 0.8 -0.1 -0.3 0.5 -0.5 -0.3 0.0
Depression (self-reported) 0.2 0.2 1.7 0.0 -0.0 -0.1 0.1 -0.2 -1.3 0.6 0.1 0.1 0.3 0.7
Medication: Lansoprazole 1.8 2.1 6.5 1.9 1.7 -1.3 -1.7 0.8 -0.1 1.2 0.6 1.6 -2.5 0.3
Prospective memory result 0.4 0.5 3.5 0.3 -0.3 0.2 -0.1 -0.0 -0.1 1.2 0.3 1.9 0.3 -0.1
Lung cancer (father) 0.6 0.7 2.2 0.3 0.3 0.4 0.2 1.3 1.5 -0.3 1.0 -1.3 -0.5 0.1
Illnesses of mother 3.1 3.8 7.7 -2.3 -2.4 0.7 2.8 -1.6 -0.2 -1.9 -1.8 -2.1 2.8 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.9 -0.1 -0.1 0.4 -0.4 -0.1 -0.9 0.9 -0.1 -0.3 -0.0 0.6
Pulse wave Arterial Stiffness index 0.3 0.4 1.1 1.0 -0.1 1.1 0.1 0.1 -0.8 -0.1 0.9 0.9 -0.2 -0.0
Impedance of arm (left) 0.6 2.7 5.4 -2.3 -1.7 -1.6 1.9 1.4 1.7 -0.1 -1.9 1.0 1.6 -1.8
Arm fat mass (right) 0.5 2.2 8.6 -1.5 -1.0 -0.1 1.6 2.9 0.3 0.6 -0.2 2.4 1.9 -0.6
Trunk predicted mass 0.1 0.7 3.5 -0.8 0.3 1.3 -0.1 -0.2 -1.9 -0.2 0.3 -0.3 0.5 1.0
Standing height 0.3 2.8 12.1 -3.5 -1.5 0.6 1.6 0.6 -1.5 -1.6 -1.7 -0.6 2.1 -0.8
Length of working week for main job 0.7 0.7 2.5 0.4 0.4 1.1 -0.5 -1.3 -1.6 0.1 0.6 0.2 -0.7 1.1
Exposure to tobacco smoke at home 0.1 0.1 0.4 -0.1 0.3 -0.2 -0.2 0.3 -0.2 -0.7 0.0 0.5 -0.2 -0.3
Breastfed as a baby 0.3 0.3 2.3 -0.3 -0.4 -0.2 -0.1 -1.5 -0.5 0.2 -0.5 -0.7 0.3 -0.3
Tense / ‘highly strung’ 1.7 2.9 5.7 1.4 1.9 0.9 -1.4 2.0 0.5 1.7 2.4 1.7 -1.6 2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.5 0.1 -0.3 -0.8 0.2 0.4 0.3 0.5 0.4 1.2 0.1 -0.1
Hair/balding pattern: Pattern 4 0.6 1.4 3.0 1.1 1.4 -0.5 -1.7 0.6 0.3 1.3 1.1 1.7 -1.0 1.2
Birth weight of first child 1.3 2.3 4.8 -2.2 -1.7 -0.6 1.5 -1.0 -0.2 -1.6 -2.1 -1.6 1.6 -1.4
Peak expiratory flow (PEF) 0.3 0.6 2.1 0.7 0.1 0.1 -1.0 -1.5 -0.3 0.5 0.1 -1.1 -1.2 0.2
Pulse wave reflection index 1.8 2.3 5.2 2.3 1.1 2.1 -1.4 -1.8 -1.3 0.7 1.8 -0.2 -0.8 1.7
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.3 -0.6 -0.3 -1.1 0.1 -0.1 -0.1 0.1 -0.7 0.6 0.2 -0.5
Loud music exposure frequency 0.3 0.3 1.5 0.2 0.3 0.6 -0.7 0.4 -0.5 0.3 0.7 1.2 -0.4 0.3
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.4 -0.6 0.5 -0.7 -0.7 -1.1 -1.6 -0.8 -1.3 -1.4 -0.7 0.2
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.3 -0.9 -0.7 0.0 1.1 1.7 -0.6 1.6 -0.1 2.1 1.2 0.1
Blood clot in the leg (DVT) 0.1 0.2 1.0 -0.0 -0.2 -0.0 0.4 0.2 1.0 -0.4 -0.3 0.7 -0.1 -0.4
Medication: Paracetamol 0.2 0.3 1.5 1.2 0.4 -0.3 0.0 -0.8 -0.2 0.8 0.2 0.2 -0.4 0.6
Headache pain in last month 0.3 0.5 0.9 0.3 -0.4 -0.7 1.0 -0.9 0.4 0.9 -0.9 0.7 0.5 -0.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 2.0 -0.4 0.3 -0.2 -0.5 -1.4 0.1 0.2 -0.3 0.1 -0.3 0.3
Glaucoma (self-reported) 0.3 0.3 1.2 1.1 0.5 -0.4 0.3 0.1 0.7 0.7 0.5 0.7 -0.4 0.2
Gout (self-reported) 0.5 0.7 3.0 0.0 0.5 0.8 -0.1 0.4 -1.3 -1.7 0.0 -1.3 0.1 0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.1 -0.2 -0.7 -0.2 0.7 1.0 0.8 0.0 -0.0 0.4 0.5 -0.5
Medication: Amlodipine 0.5 0.7 3.4 -0.2 -0.2 1.3 0.6 0.5 -1.8 -1.2 -0.4 -0.2 0.5 0.2
Medication: Ventolin 100micrograms inhaler 2.0 2.5 4.7 -1.9 -1.8 -2.2 1.3 -1.8 1.8 0.6 -1.9 -0.8 1.1 -1.5
Birth weight 1.7 3.6 7.7 -2.3 -2.4 -1.1 0.6 -2.8 -0.5 -2.2 -2.4 -1.5 1.6 -2.0
Chronic bronchitis/emphysema (mother) 1.1 1.3 4.2 -1.5 -0.9 -2.1 1.0 -0.2 0.8 -0.2 -1.8 -0.5 1.2 -1.0
High blood pressure (siblings) 0.7 1.0 2.2 1.5 1.2 1.0 -1.4 0.8 -0.4 -0.4 1.1 0.4 -1.3 0.5
Forced vital capacity (FVC), Best measure 0.1 0.4 2.2 -0.5 -0.3 0.7 -0.1 -0.3 -1.5 0.4 -0.3 -0.7 0.3 0.6
Body fat percentage 1.0 4.0 9.1 -2.4 -2.1 -0.3 2.6 3.0 0.4 0.1 -1.2 2.2 2.9 -1.7
Leg fat percentage (right) 0.5 1.9 4.3 -1.4 -1.3 -0.2 1.7 2.0 0.0 0.4 -0.7 2.0 2.1 -0.9
Arm fat-free mass (right) 0.1 0.7 3.1 -0.9 -0.0 1.1 0.0 0.6 -1.8 0.5 0.3 0.6 0.7 0.8
Exposure to tobacco smoke outside home 0.4 0.5 2.8 0.1 0.5 0.9 0.6 1.7 -0.1 0.0 0.7 0.1 0.2 0.8
Comparative body size at age 10 0.6 1.6 3.6 1.1 1.6 0.6 -1.9 0.9 -0.8 1.2 1.2 0.2 -1.4 1.9
Number of full brothers 0.5 0.7 5.3 -0.2 -0.6 -0.2 -0.1 -2.3 0.4 1.1 -0.0 0.3 0.4 0.0
Worry too long after embarrassment 0.3 0.5 3.3 -0.6 -0.3 -0.4 0.3 1.8 0.8 0.6 0.8 0.3 0.0 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 3.7 0.6 0.6 0.1 -0.1 1.3 -1.8 1.2 0.7 1.9 -0.0 0.7
Wheeze or whistling in the chest in last year 0.6 1.0 2.7 -1.4 -0.7 -1.6 1.2 0.6 1.5 0.5 -1.0 0.0 0.7 -0.4
Number of children fathered 0.7 0.8 3.0 0.3 0.3 -0.0 -0.9 -0.3 -0.6 1.7 0.7 1.7 -0.2 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 3.6 0.0 -0.2 -0.5 0.8 1.9 1.1 -0.3 -0.2 0.6 0.2 -1.1
Age at first live birth 0.2 0.3 1.7 -0.2 0.2 1.3 -0.4 -0.4 -0.1 0.3 0.2 -0.5 0.5 0.7
Pulse wave peak to peak time 0.3 0.4 1.3 -1.1 0.1 -0.8 -0.1 -0.0 0.7 0.0 -0.9 -1.0 0.3 0.1
Health satisfaction 1.8 2.4 11.4 0.0 0.9 -1.9 -0.7 3.4 0.9 1.5 0.2 2.3 -1.2 0.1
Shortness of breath walking on level ground 3.1 3.7 5.7 -2.2 -2.3 -2.2 2.1 0.7 1.6 0.3 -1.9 1.8 2.3 -2.4
Qualifications: College or University degree 0.1 0.2 1.1 0.2 0.2 -1.0 0.1 -0.1 0.7 -0.3 -0.2 0.2 -0.2 -0.3
Eye problems/disorders: None of the above 0.3 0.3 1.1 -0.8 -0.5 0.2 0.5 0.7 0.1 -1.1 -0.4 0.1 0.6 -0.6
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.5 1.2 0.9 1.0 -0.9 -0.1 -1.2 0.0 1.0 -1.6 -1.1 1.2
Emphysema/chronic bronchitis 0.2 0.2 1.2 0.2 -0.1 -0.6 -0.2 0.7 -0.4 0.6 -0.1 1.1 -0.2 -0.3
Medication for pain relief, constipation, heartburn 0.3 0.5 2.6 -1.6 -0.3 1.0 -0.3 0.3 -1.2 0.5 -0.5 -0.1 0.4 0.2
Neck or shoulder pain in last month 0.7 1.1 5.1 0.1 -0.2 -0.8 0.9 0.9 1.5 1.2 0.0 2.3 0.8 -0.2
Medication: Blood pressure 0.2 0.3 1.2 0.6 0.4 0.2 -0.3 1.1 -0.4 0.4 0.3 -0.4 -0.5 0.6
Angina (self-reported) 0.5 0.6 1.4 0.5 0.8 1.2 -0.5 0.6 -0.8 -0.9 1.1 -0.6 -0.4 0.7
Migraine (self-reported) 1.1 1.4 2.9 -0.9 -1.4 -1.4 1.7 -1.0 0.9 -0.7 -1.3 -0.8 1.3 -1.2
Medication: Ibuprofen 0.8 1.0 4.0 -0.1 -0.2 -2.0 0.8 -0.8 1.9 0.7 -0.7 0.6 0.6 -0.2
Medication: Allopurinol 0.2 0.2 1.5 0.2 0.5 0.2 -0.4 0.5 -0.4 -1.2 0.3 -0.1 -0.4 0.2
Medication: Omeprazole 0.5 0.6 1.7 -0.9 -0.5 -0.0 0.9 1.3 1.1 -0.3 0.3 0.8 0.6 -0.1
Medication: Seretide 50 evohaler 0.8 0.9 3.6 -0.4 -0.8 -0.0 1.9 1.0 1.2 0.8 0.1 -0.5 1.4 -0.3
Mean time to correctly identify matches 1.0 2.0 7.6 2.8 2.0 0.1 -0.9 1.3 1.3 -0.4 1.9 0.2 -1.6 0.5
Heart disease (mother) 1.3 1.6 4.5 0.8 1.0 -1.5 -1.3 1.6 2.1 0.9 0.5 1.1 -1.7 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 4.9 -1.1 -0.8 -2.2 1.1 -0.6 2.1 0.1 -1.3 -0.7 0.4 -1.0
Whole body fat mass 0.8 3.4 8.6 -2.5 -1.8 -0.1 2.3 2.9 0.0 0.4 -1.0 2.2 2.7 -1.2
Leg fat mass (right) 0.6 2.2 6.2 -1.8 -1.2 0.1 1.7 2.5 -0.4 0.3 -0.5 2.1 2.2 -0.7
Arm predicted mass (right) 0.1 0.8 3.4 -0.6 0.3 1.2 -0.1 0.8 -1.8 0.6 0.6 0.6 0.5 1.1
Pulse rate, automated reading 0.4 1.3 7.1 0.4 0.8 1.0 -0.3 2.7 -0.6 0.5 0.9 1.6 -0.6 0.5
Alcohol intake frequency. 0.4 0.8 3.8 0.3 0.1 1.9 -0.5 -0.0 -1.4 -0.2 0.7 1.4 0.2 0.6
Comparative height size at age 10 0.2 1.2 3.6 -1.1 1.0 1.1 -0.1 1.5 -1.0 -1.9 0.0 -1.6 0.2 0.6
Number of full sisters 0.3 0.4 0.9 0.9 0.4 0.3 -0.9 -0.4 -0.6 -0.9 0.5 0.1 -0.8 0.2
Suffer from ‘nerves’ 0.5 0.7 1.9 1.0 0.8 0.3 -1.3 0.0 -0.3 0.2 1.2 -0.3 -1.4 1.0
Overall health rating 1.0 2.2 6.5 -0.8 -1.6 -0.4 2.1 1.8 -0.7 -0.1 -0.5 2.6 1.9 -1.3
Chest pain or discomfort 2.2 3.1 10.6 -1.1 -2.3 -1.3 1.9 0.5 1.2 1.6 -0.6 3.3 2.1 -1.7
Had major operations 0.7 0.9 2.0 -1.4 -1.1 -0.8 1.1 -0.2 0.9 -0.8 -1.1 -0.6 0.8 -0.8
Age at last live birth 0.4 0.5 2.0 -0.3 0.5 1.4 -0.7 0.6 0.6 0.6 0.9 0.7 0.3 0.8
Family relationship satisfaction 1.5 1.8 5.5 0.7 2.2 -0.8 -1.8 1.9 -0.2 -0.2 0.5 -0.6 -2.3 0.9
Leg pain on walking 0.3 0.3 1.0 -0.2 -0.3 -0.5 0.2 -0.2 -0.8 -0.9 -1.0 -0.6 -0.0 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.7 -1.0 -1.3 -0.2 1.1 -0.3 0.5 0.1 -0.7 -0.1 0.9 -1.1
Commuting to job workplace: Car/motor vehicle 1.5 1.7 6.6 2.6 1.9 0.0 -1.3 0.3 -0.2 0.1 1.2 -0.3 -2.2 0.7
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.7 0.4 -0.1 -0.3 0.5 0.1 0.6 -0.6 -0.5 0.1 0.5 -0.8
Medication: Aspirin 1.0 1.3 3.3 1.6 1.4 0.2 -0.7 1.8 0.6 -1.1 1.5 0.6 -1.5 0.4
Supplements: Vitamin C 1.1 1.3 3.3 1.5 0.8 -0.8 -1.7 -1.8 0.0 0.7 0.1 -1.1 -1.7 0.3
Knee pain experienced in last month 0.1 0.2 0.8 0.3 -0.2 0.7 0.9 0.0 -0.2 -0.4 0.2 -0.3 0.5 0.1
Hypertension (Self-reported) 0.4 1.2 4.1 1.5 0.9 -0.2 0.1 2.0 0.4 1.2 0.9 1.5 -1.0 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 3.7 1.5 1.5 -0.1 -1.0 1.2 0.7 1.1 1.3 0.7 -1.9 1.3
Illnesses of father: Heart disease 1.4 2.0 5.1 2.2 1.7 0.6 -1.2 0.5 0.0 1.6 1.9 0.9 -1.6 1.5
Illnesses of siblings: Diabetes 0.1 0.2 0.4 -0.5 -0.3 0.2 0.4 -0.6 -0.3 -0.2 -0.5 -0.5 0.6 -0.1
Smoking status: Previous 1.0 1.5 3.2 -1.8 -1.4 -1.1 1.7 0.0 0.2 0.4 -1.7 0.3 1.8 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 6.3 -2.3 -2.0 -1.7 2.5 0.9 0.9 0.1 -1.9 0.8 1.9 -2.0
Whole body fat-free mass 0.1 0.8 3.3 -1.0 0.1 1.1 0.2 0.9 -1.8 0.3 0.3 0.8 0.7 0.8
Leg fat-free mass (right) 0.2 1.3 5.9 -1.0 0.1 1.1 0.4 2.4 -1.3 0.5 0.7 1.5 0.8 0.7
Arm fat percentage (left) 0.6 2.5 8.4 -1.4 -1.2 -0.6 1.8 2.9 0.9 0.9 -0.5 2.4 1.9 -1.0
Average weekly red wine intake 0.1 0.2 1.3 -0.3 -0.2 -0.1 -0.1 -0.1 0.4 1.1 -0.1 -0.3 -0.1 0.3
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.7 0.7 0.9 -0.7 -1.0 -0.1 0.0 -0.4 0.3 0.5 -1.3 -0.1
Mood swings 0.8 1.5 5.3 1.0 0.7 0.1 0.8 2.3 -0.2 1.0 1.3 2.3 0.0 1.0
Loneliness, isolation 1.2 1.7 6.7 -0.2 -0.5 -1.6 1.0 1.9 1.3 1.4 0.2 2.6 0.7 -0.9
Long-standing illness, disability or infirmity 0.4 0.6 2.6 0.7 -0.4 -1.6 0.4 0.5 0.6 0.2 -0.4 1.4 0.2 -0.9
Ever had bowel cancer screening 0.5 0.6 1.4 -0.6 -0.8 -0.5 0.9 0.0 1.2 -0.6 -0.5 1.1 0.8 -0.8
Diabetes diagnosed by doctor 0.1 0.2 0.8 0.5 -0.1 -0.6 -0.0 0.5 0.5 -0.4 0.0 0.9 0.3 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.2 0.2 -0.1 -1.0 -0.0 -1.1 0.2 0.7 -0.2 -0.2 -0.7 -0.4
Friendships satisfaction 1.1 1.3 5.9 0.5 0.8 0.2 -0.7 -0.5 -0.7 -2.3 -0.2 -2.4 -1.0 0.1
Qualifications: nursing, teaching 0.2 0.3 2.2 0.1 0.2 -1.5 -0.1 -0.1 0.4 0.8 -0.1 0.2 -0.7 0.0
Commuting to job workplace: Walk 2.4 2.5 5.4 -2.2 -2.3 -1.3 1.8 -1.0 0.8 -0.8 -1.9 -0.5 2.0 -1.5
Eye problems/disorders: Cataract 0.2 0.3 0.8 -0.5 -0.1 0.0 -0.1 -0.8 -0.4 0.7 -0.8 -0.9 0.1 0.3
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 4.2 1.7 2.0 1.2 -1.8 1.7 -0.3 -0.3 1.8 0.9 -1.7 1.3
Medication for cholesterol 0.4 0.5 2.9 -1.7 -1.0 0.4 0.1 -0.1 0.7 0.1 -0.1 -0.4 1.0 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 3.1 0.4 -0.3 0.2 0.5 -0.6 0.5 -0.6 -0.0 -1.8 0.8 -0.1
Back pain experienced in last month 0.7 1.0 7.3 0.4 -0.2 -0.3 -0.1 -0.3 0.4 1.7 0.5 2.7 0.4 0.2
Mineral and other dietary supplements 0.3 0.5 2.8 0.2 0.4 -1.0 -0.6 -0.4 -0.1 0.7 0.1 1.7 -0.0 0.0
Breast cancer (self-reported) 0.9 1.1 2.8 0.7 1.0 1.1 -0.8 1.6 -0.5 1.4 1.7 0.4 -0.4 1.2
Asthma (self-reported) 0.6 1.3 2.4 -1.2 -1.3 -1.6 1.3 -1.0 0.5 0.8 -1.5 -0.0 1.1 -1.1
Osteoporosis (self-reported) 1.1 1.4 4.9 -1.4 -0.7 -2.2 0.4 0.1 1.9 -0.7 -1.3 0.6 0.4 -1.3
Osteoarthritis (self-reported) 0.4 0.5 1.6 -0.4 -0.2 -1.0 0.6 -0.0 0.1 -0.8 -1.1 -1.3 0.4 -0.7
Medication: Aspirin 0.9 1.2 2.5 1.4 1.2 0.2 -0.8 1.6 0.7 -1.1 1.4 0.4 -1.4 0.4
Medication: Gliclazide 0.8 0.9 2.5 -0.8 -0.8 -1.0 0.6 1.4 1.2 0.3 -0.5 1.6 0.7 -0.9
Illnesses of father: None of the above (group 1) 3.6 4.5 8.4 -2.9 -2.5 -1.6 2.8 0.7 1.3 -2.0 -2.4 -0.9 2.3 -2.5
Smoking status: Current 0.2 0.4 1.2 0.7 0.7 0.6 -0.1 -0.2 -0.8 0.5 0.7 -0.0 -0.4 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.7 0.2 -0.7 0.8 0.5 -0.3 -0.7 -0.4 -0.0 -0.5 0.8 -0.1
Whole body water mass 0.1 0.7 2.8 -1.0 0.1 1.0 0.2 0.7 -1.7 0.2 0.3 0.6 0.8 0.8
Leg predicted mass (right) 0.3 1.3 6.0 -1.0 0.1 1.1 0.4 2.5 -1.4 0.5 0.7 1.6 0.8 0.7
Arm fat mass (left) 0.5 2.0 7.9 -1.2 -0.9 -0.1 1.5 2.8 0.3 0.9 -0.0 2.4 1.7 -0.5
Number of self-reported non-cancer illnesses 1.1 1.9 6.5 2.2 1.2 -0.5 -0.4 2.5 0.8 0.0 1.5 1.7 -1.4 0.1
Average weekly champagne plus white wine intake 0.6 0.8 2.3 -0.7 -1.4 -0.4 0.9 -1.5 -0.2 -0.7 -0.6 0.3 1.1 -1.0
Miserableness 0.9 1.6 9.7 0.3 0.0 -0.4 0.7 2.0 -0.1 1.5 1.0 3.1 0.4 0.3
Guilty feelings 0.3 0.5 1.1 0.4 0.7 -0.6 -0.5 1.0 0.5 0.8 0.4 0.6 -0.9 0.7
Wears glasses or contact lenses 0.5 0.6 1.8 0.3 0.8 -0.5 -1.4 -0.6 1.0 -0.7 0.7 -0.4 -1.1 0.5
Ever taken oral contraceptive pill 0.4 0.4 1.8 -0.1 -1.1 0.1 0.2 -1.3 -0.3 0.4 -0.4 0.8 0.6 -0.3
Hearing aid user 1.6 1.8 3.4 -0.9 -1.5 -1.4 1.3 -1.2 1.8 -1.3 -1.5 -0.9 1.0 -1.8
Mother’s age at death 2.5 3.1 7.9 -1.8 -2.0 -0.3 1.2 -2.8 -1.5 -1.1 -2.5 -1.6 1.7 -1.6
Financial situation satisfaction 1.0 1.2 2.4 1.1 1.2 0.4 -1.4 1.0 -0.4 1.5 1.1 0.6 -1.1 1.6
Tinnitus: Yes, now most or all of the time 1.8 2.1 6.7 2.6 1.8 1.8 -1.6 0.7 -0.3 -0.3 1.9 0.1 -1.3 1.4
Commuting to job workplace: Public transport 0.5 0.7 2.8 0.2 0.1 -0.2 -0.7 0.9 0.4 1.7 0.8 1.4 -0.4 0.6
Eye problems/disorders: Glaucoma 0.4 0.5 2.2 0.2 -0.7 -0.2 1.1 -1.5 0.8 -0.3 -0.5 -0.4 0.6 -0.5
Medication: Blood pressure 0.9 1.7 4.7 2.0 1.3 1.0 -0.7 1.7 -1.2 0.1 1.4 2.2 -1.0 0.6
Pain type(s) experienced in last month: Hip pain 1.9 2.4 4.8 -1.0 -2.1 -1.0 2.2 1.2 1.8 0.2 -0.7 1.4 1.8 -2.1
Supplements: Fish oil (including cod liver oil) 0.6 0.7 3.4 0.8 0.3 1.3 0.1 0.3 0.3 -1.1 0.5 -1.8 -0.7 0.3
High cholesterol (Self-reported) 0.5 0.9 2.2 1.5 1.4 0.7 -0.5 0.6 -1.2 0.1 0.6 -0.9 -0.8 1.1
Medication: Bendroflumethiazide 0.3 0.4 2.6 0.2 0.3 -1.0 -0.1 0.4 -0.1 1.6 -0.4 0.7 -0.5 0.3
Medication: Paracetamol 0.1 0.2 0.6 0.6 -0.0 -0.3 0.7 -0.5 -0.0 0.8 -0.1 0.2 0.2 0.4
Medication: Lisinopril 1.4 1.8 6.4 -0.9 -2.0 -1.6 0.7 -1.1 0.3 -0.7 -1.6 0.6 0.9 -2.5
Medication: Atorvastatin 1.0 1.2 4.0 -0.7 -1.4 -2.0 1.2 -0.6 0.6 0.4 -1.3 -0.1 1.1 -1.4
Illnesses of father: High blood pressure 1.3 1.6 4.7 1.5 1.0 0.9 -1.4 0.2 -0.6 2.2 1.4 0.8 -1.4 1.2
Alcohol drinker status: Never 0.3 0.3 1.2 -0.2 0.0 1.0 -0.2 0.9 0.4 -0.5 0.5 1.1 0.4 0.2
Ever smoked 0.2 0.3 1.2 -0.2 0.3 -1.0 0.1 -1.1 -0.3 0.0 -0.8 -0.5 -0.0 0.2
Basal metabolic rate 0.2 0.9 2.1 -1.4 -0.3 0.8 0.7 1.4 -1.4 0.2 0.0 1.1 1.2 0.4
Leg fat percentage (left) 0.5 1.8 4.4 -1.3 -1.4 -0.0 1.7 2.1 0.1 0.1 -0.5 1.6 2.1 -1.1
Arm fat-free mass (left) 0.1 0.6 2.1 -0.8 0.3 1.1 0.0 0.9 -1.5 0.3 0.5 0.5 0.6 0.9
Number of operations (self-reported) 0.3 0.5 2.9 -0.1 0.3 -0.8 -0.2 0.3 1.7 1.3 0.2 0.2 -0.1 0.2
Average weekly beer plus cider intake 1.9 2.7 7.3 -1.6 -1.6 -0.8 2.5 1.0 -0.1 0.1 -1.1 2.5 2.7 -1.6
Irritability 0.6 1.0 2.5 -1.6 -1.4 -0.2 1.3 -0.9 -0.5 -0.6 -0.8 -0.6 1.4 -0.7
Risk taking 1.5 2.2 9.7 0.8 1.1 0.7 -0.5 2.2 -0.4 1.8 1.6 3.1 -0.4 1.0
Ever had prostate specific antigen (PSA) test 1.5 1.7 8.0 0.5 0.7 1.7 -0.6 -1.1 -2.8 -1.9 -0.4 -1.4 -0.0 0.3
Fractured/broken bones in last 5 years 0.8 1.0 2.5 0.8 0.9 1.1 -0.7 0.8 -0.6 0.9 1.6 1.1 -0.3 1.5
Age started oral contraceptive pill 1.8 2.2 6.2 1.5 1.0 2.0 -1.3 1.2 -0.4 0.7 2.5 2.1 -0.3 1.6
Diastolic blood pressure, automated reading 0.5 1.6 7.0 0.3 0.5 1.2 -0.1 2.7 0.7 1.2 1.8 1.8 -0.0 0.4
Ever depressed for a whole week 0.8 1.0 3.8 -0.2 0.2 -1.1 -0.1 2.0 1.5 0.5 0.1 2.0 -0.2 -0.2
Unable to work because of sickness or disability 0.3 0.4 0.9 0.8 -0.5 0.9 0.9 -0.1 -0.2 -0.9 0.5 -0.7 0.6 -0.2
Commuting to job workplace: Cycle 0.7 0.9 1.8 -1.1 -0.7 0.2 1.1 0.1 1.3 -1.2 -0.5 -1.3 0.9 -0.5
Myopia 1.9 2.7 6.6 1.7 1.9 1.7 -1.4 2.0 0.5 1.0 2.6 0.4 -1.5 1.9
Vascular/heart problems diagnosed by doctor 0.4 1.1 5.6 -1.1 -0.0 0.7 -0.9 -2.4 -0.9 -0.4 -0.5 -1.5 0.2 0.8
Cholesterol lowering medication 0.2 0.3 0.9 1.0 0.9 -0.1 0.3 -0.4 -0.4 -0.3 -0.1 -0.8 -0.4 0.4
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.5 -1.2 -1.0 0.4 1.6 1.4 0.6 -1.0 -0.0 0.7 1.4 -0.6
Pain experienced in last month 0.4 0.6 3.5 -1.1 -0.5 0.5 -0.2 0.0 -0.2 -1.1 -0.4 -1.9 0.1 -0.4
Supplements: Calcium 0.5 0.5 2.0 0.0 -0.8 -0.2 0.3 -1.3 0.4 0.8 -0.2 1.4 0.5 -0.6
Basal cell carcinoma (self-reported) 0.4 0.5 2.3 0.1 0.0 0.4 0.2 -0.8 -1.5 0.7 -0.5 0.8 0.2 0.7
Heart attack/myocardial infarction (self-reported) 2.4 3.1 7.0 -0.8 -2.4 -2.4 2.2 -0.9 0.9 -1.5 -1.7 -0.9 1.8 -2.6
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.6 -0.1 -0.3 0.2 0.5 0.1 0.8 -0.4 -0.3 0.7 0.1 -0.3
Heart disease (siblings) 0.3 0.3 0.8 0.6 0.5 -0.9 -0.2 0.4 0.8 0.5 0.2 0.7 -0.6 0.1
Alcohol drinker status: Previous 0.4 0.4 1.8 0.2 -0.0 0.8 0.4 1.3 -0.8 0.4 0.7 0.7 0.4 0.2
Pack years of smoking 1.3 1.8 3.6 1.9 1.8 1.2 -1.2 0.0 -1.8 0.1 1.4 0.6 -1.1 1.9
Impedance of whole body 0.5 2.3 5.6 -2.4 -1.9 -1.1 1.7 0.5 1.3 -0.7 -2.1 -0.0 1.6 -1.8
Leg fat mass (left) 0.6 2.3 7.5 -1.9 -1.3 0.1 1.8 2.7 -0.2 0.4 -0.5 2.0 2.2 -0.8
Arm predicted mass (left) 0.1 0.6 2.3 -1.1 -0.0 0.9 0.3 0.8 -1.5 -0.2 0.1 0.2 0.9 0.4