Hub : Genes

ZNF704

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1090 0.0410 4.5e-04 0.043 NA 0.015 NA 0.032 0.00020 NA 1.9e-02 NA 1.1e-03
2 GTEx Nerve Tibial 0.1365 0.0511 1.1e-03 -0.004 NA 0.001 NA -0.003 0.94000 NA 2.6e-01 NA 5.6e-01
3 GTEx Testis 0.2770 0.0840 8.0e-04 0.018 NA 0.086 NA 0.078 0.05400 NA 1.2e-04 NA 2.4e-04
4 GTEx Thyroid 0.1090 0.0400 1.8e-03 0.015 NA -0.002 NA 0.000 0.02300 NA 5.7e-01 NA 2.9e-01
5 ROSMAP Brain Pre-frontal Cortex 0.0523 0.0189 2.9e-04 0.000 0.024 0.010 0.023 0.004 0.27000 4.1e-04 1.6e-02 0.00052 7.7e-02
6 TCGA Glioblastoma Multiforme 0.3680 0.2150 9.4e-03 0.087 0.055 0.100 NA 0.101 0.00130 8.9e-03 5.9e-04 NA 5.5e-04
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0694 0.0294 1.4e-05 0.032 0.050 0.048 NA 0.047 0.00013 2.2e-06 4.2e-06 NA 4.7e-06
8 TCGA Prostate Adenocarcinoma 0.0412 0.0234 6.1e-03 0.013 0.013 0.002 NA 0.004 0.01500 1.5e-02 1.6e-01 NA 1.1e-01
9 TCGA Uterine Corpus Endometrial Carcinoma 0.1480 0.0740 2.7e-03 0.031 0.075 0.036 NA 0.064 0.04600 3.9e-03 3.7e-02 NA 7.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.7 1.2 4.3 0.9 0.0 -0.6 -0.6 0.7 1.1 2.1 1.4 1.0
Bipolar Disorder or Schizophrenia 0.4 1.0 2.5 1.1 0.0 0.1 -0.2 0.9 1.1 1.6 1.3 1.4
Depressed Affect (Nagel 2018) 0.2 0.4 1.7 0.2 0.0 -1.3 -0.6 0.1 -0.0 0.9 -0.4 0.5
Depression (Nagel 2018) 0.3 0.4 1.5 -0.2 0.0 1.0 -1.2 0.1 0.6 0.5 -0.8 0.3
Intelligence (Savage-Jansen 2018) 0.7 2.1 7.3 -0.1 0.0 1.3 -2.7 1.4 1.6 1.5 -1.5 1.1
Neuroticism (Nagel 2018) 0.3 0.7 2.2 -0.6 0.0 -1.2 -1.5 -0.3 -1.0 -0.1 -1.0 -0.1
Schizophrenia (2018) 0.2 0.4 1.0 0.7 0.0 0.7 0.3 0.6 0.5 0.4 0.6 1.0
Schizophrenia vs Biploar Disorder 0.1 0.2 0.6 0.1 0.0 -0.7 0.7 0.1 0.1 -0.5 0.5 -0.1
Worry (Nagel 2018) 0.4 0.9 4.2 0.2 0.0 0.4 -2.1 0.8 -0.5 1.3 -0.1 1.1
Alzheimer’s Disease (in mother) 0.7 0.8 1.8 -1.3 0.0 -1.0 0.2 -1.1 -0.8 -0.7 -0.5 -1.4
Alzheimer’s Disease (in father) 0.8 0.9 4.0 0.3 0.0 2.0 0.6 0.3 1.7 0.4 0.7 0.2
Alzheimer’s Disease (including proxy) 0.7 1.0 2.8 -1.3 0.0 0.1 1.5 -1.2 0.5 -0.5 0.7 -1.7
Crohns Disease (2017) 0.9 1.9 5.2 1.8 0.0 0.3 0.7 2.3 1.1 1.0 1.8 1.5
Irritable Bowel Disease (IBD) 0.2 0.6 2.0 1.3 0.0 -0.2 0.1 1.4 -0.4 0.1 0.5 1.0
Ulcerative Colitis (UC) 0.3 0.5 2.2 0.3 0.0 -0.6 -0.6 0.3 -1.5 -0.7 -1.0 0.1
Major Depression (MDD) 0.2 0.2 1.0 -0.1 0.0 -1.0 -0.0 0.6 0.0 -0.1 -0.8 0.1
Reaction Time 0.3 0.6 2.5 -0.2 0.0 -0.9 -0.1 -0.6 -1.6 -0.6 0.6 -0.8
Verbal and Numeric Reasoning (VNR) 1.1 2.6 5.8 0.9 0.0 1.2 -2.0 1.9 1.9 2.4 0.2 2.0
Breast Cancer 2.2 5.2 14.4 -2.5 0.0 -1.1 1.7 -3.8 0.4 -2.1 2.4 -3.4
Ovarian Cancer 0.9 1.2 6.1 -0.2 0.0 -0.8 1.8 -0.1 -2.5 -0.7 -0.6 -0.6
Prostate Cancer 0.8 1.2 4.8 1.5 0.0 -0.5 1.2 1.0 -0.3 0.4 2.2 0.7
Age at First Birth 0.6 0.8 3.4 -0.4 0.0 1.8 1.0 0.0 1.0 1.3 0.5 -0.3
Bipolar Disorder (2011) 0.4 0.4 0.9 -0.8 0.0 -0.1 -0.9 0.1 0.7 -0.5 -0.7 -0.6
Body Mass Index (BMI) (2010) 0.4 0.5 2.4 -0.5 0.0 -1.5 0.1 -0.6 -0.1 -0.7 -0.9 -0.4
Coronary Artery Disease (CAD) 0.4 0.4 2.7 -0.1 0.0 -1.6 -0.8 -0.2 -0.3 -0.1 -0.6 -0.1
Crohns Disease (2012) 2.4 3.9 8.2 2.8 0.0 0.8 -0.1 2.7 0.7 2.3 2.4 2.9
Mean Putamen Volume 1.7 1.9 6.7 -0.9 0.0 -2.6 -0.3 -0.7 -0.3 -2.1 -1.8 -1.1
Fasting Glucose 2.4 2.8 8.5 -2.6 0.0 -0.6 -0.5 -2.9 -2.0 -1.2 -0.1 -2.1
HbA1C 0.3 0.3 1.2 0.1 0.0 -0.5 -0.3 0.2 1.1 0.8 0.9 0.3
HDL Cholesterol 0.7 1.2 4.1 -0.2 0.0 2.0 0.6 -0.5 0.6 1.4 1.8 0.1
LDL Cholesterol 0.5 0.8 3.1 0.2 0.0 -0.2 1.8 -0.9 -0.5 0.7 1.6 -0.2
Lupus 0.3 0.5 1.3 0.7 0.0 -0.3 0.9 0.8 -0.1 1.2 1.0 0.2
Neuroticism (2016) 0.5 0.7 3.9 -0.8 0.0 0.7 -0.6 -2.0 0.9 -0.2 -0.0 -0.4
Primary Biliary Cirrhosis 1.0 1.4 3.2 1.8 0.0 0.7 1.1 1.6 -1.3 1.2 0.5 1.4
Rheumatoid Arthritis 1.9 2.6 4.9 -2.0 0.0 -0.9 0.3 -2.0 -2.2 -2.0 -1.5 -1.8
Schizophrenia (2014) 0.3 0.6 1.7 0.8 0.0 -0.2 1.2 0.5 0.3 0.7 1.3 0.8
Triglycerides 1.1 1.7 3.0 -1.7 0.0 -1.2 -0.2 -1.0 -1.3 -1.6 -1.7 -1.7
Type 2 Diabetes (T2D) (2012) 0.4 0.5 2.1 -0.5 0.0 -0.8 -1.4 -0.6 -0.6 -0.3 -0.7 -0.0
Ulcerative Colitis 0.2 0.3 1.1 1.0 0.0 -0.1 -0.1 0.1 -0.7 -0.3 0.0 0.8
Blood Eosinophil Count 0.1 0.5 1.5 -1.2 0.0 -0.9 -0.8 -0.5 1.0 0.3 -0.2 -0.3
Blood Platelet Count 0.2 1.9 7.6 0.8 0.0 1.5 -1.4 1.2 0.5 2.8 0.1 1.6
Blood Red Count 0.7 6.4 22.9 2.3 0.0 -2.5 -1.6 4.8 -1.2 1.5 -3.1 2.6
Blood White Count 0.0 0.2 1.7 0.0 0.0 -0.3 -0.1 0.3 -1.3 -0.3 0.3 -0.3
Heel T-Score 0.8 6.7 28.1 0.7 0.0 -2.1 -2.0 2.8 -3.3 -2.0 -5.3 0.7
BMI 0.8 4.5 10.6 3.2 0.0 -1.3 -0.3 2.4 0.3 3.0 1.9 3.2
Height 0.5 10.6 23.1 -4.8 0.0 -1.0 -0.6 -4.0 -1.4 -4.5 -3.6 -4.4
Waist Hip Ratio (WHR) 0.5 2.1 5.8 -0.8 0.0 -0.7 1.4 -2.4 -0.7 -2.4 0.4 -1.8
Systolic Blood Pressure 0.2 0.8 2.2 0.2 0.0 -0.3 -1.2 0.4 -1.3 1.5 -1.1 0.9
Smoking Status 0.3 0.8 2.9 -0.9 0.0 -1.7 -0.7 -1.5 -0.2 -0.3 0.1 -0.7
Allergy or Eczema 0.2 0.6 2.0 -0.8 0.0 0.6 0.1 -0.1 0.6 -1.1 -1.4 -0.7
Cardiovascular Disease 0.1 0.5 1.7 -0.1 0.0 -0.8 0.8 -0.9 -1.3 0.4 -0.3 -0.5
Hypothyroidism (self reported) 0.4 0.8 2.0 0.3 0.0 1.0 -1.0 0.2 1.4 1.0 1.1 1.1
Respiratory disease 0.3 0.6 1.6 -0.6 0.0 0.9 1.3 -0.2 0.0 -1.2 0.3 -0.9
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.0 0.6 0.0 -0.9 -0.0 -0.1 -0.7 1.0 0.0 0.8
Lung FEV1/FVC ratio 0.3 1.6 5.9 0.0 0.0 -2.1 0.8 -1.2 1.5 -0.1 2.4 -0.0
Lung FVC 0.5 2.7 9.0 -1.7 0.0 -0.6 0.2 -0.8 0.5 -2.7 -3.0 -1.9
Neuroticism 0.2 0.5 2.3 -1.1 0.0 -0.2 -0.5 -1.5 -0.4 -0.4 -0.2 -0.6
Chronotype (morning person) 0.9 2.1 4.4 1.5 0.0 2.1 0.7 1.4 -0.3 2.0 1.9 1.5
Hair Pigment 0.1 1.6 5.9 1.0 0.0 2.4 1.5 -0.2 -0.4 -0.2 2.2 0.3
Tanning 0.1 0.9 2.8 1.2 0.0 -0.3 0.3 1.2 0.3 0.9 1.7 1.0
Hand grip strength (left) 1.0 2.6 4.9 -2.2 0.0 -0.3 -0.5 -2.2 1.2 -2.1 -2.1 -1.8
Number of treatments/medications taken 0.7 1.2 4.5 0.5 0.0 -0.3 1.8 0.6 -2.1 -0.9 -1.3 -0.6
Average weekly spirits intake 0.1 0.1 0.3 -0.5 0.0 0.1 -0.5 0.3 0.5 -0.5 0.2 -0.4
Sensitivity / hurt feelings 0.6 1.0 2.2 -1.3 0.0 -0.1 0.3 -1.3 -1.5 -1.0 -0.2 -1.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 2.1 0.1 0.0 0.0 -1.0 0.4 1.5 0.7 0.1 0.4
Hearing difficulty/problems: Yes 0.2 0.3 1.4 -0.1 0.0 -0.4 -0.9 -0.5 0.5 1.2 0.1 0.3
Relative age of first facial hair 1.4 3.0 6.7 -2.6 0.0 1.3 0.9 -2.5 -0.0 -2.2 -0.6 -2.5
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 2.1 -0.1 0.0 0.3 1.4 -0.2 -0.2 -0.8 1.0 -0.7
Ever used hormone-replacement therapy (HRT) 2.0 2.5 5.9 2.2 0.0 0.7 -0.7 2.2 0.3 2.1 1.2 2.4
Ever had hysterectomy (womb removed) 3.3 3.7 8.0 2.5 0.0 -1.7 0.5 2.5 -0.2 2.7 1.5 2.8
Systolic blood pressure, automated reading 0.4 1.2 6.6 -0.6 0.0 -1.4 -0.8 0.1 -2.6 0.5 -0.9 -0.1
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 4.3 0.9 0.0 1.7 2.1 0.3 0.4 0.2 1.3 0.5
Angina 0.4 0.6 1.8 -0.6 0.0 -1.2 -0.7 0.2 -0.8 -0.2 -1.3 -0.6
Medication for hormone replacement therapy 0.7 0.8 1.9 0.9 0.0 1.0 -0.3 1.0 1.1 1.4 0.6 1.1
Vitamin and mineral supplements 0.6 0.9 2.2 -0.4 0.0 -0.2 -0.4 -1.4 -1.4 -1.1 -1.5 0.0
Supplements: Zinc 0.4 0.5 1.6 0.7 0.0 -0.2 0.4 0.9 -0.3 1.3 0.7 0.8
Medication: Co-codamol 0.4 0.4 2.1 0.4 0.0 -1.1 1.4 0.4 -0.4 0.5 0.2 -0.2
Medication: Metformin 0.6 0.8 5.0 0.1 0.0 -0.7 0.7 0.5 -2.2 1.0 0.6 -0.2
Diabetes (father) 0.3 0.4 1.6 0.6 0.0 -1.2 0.4 -0.2 -0.2 0.6 0.8 0.4
Diabetes (mother) 2.7 3.4 7.8 2.7 0.0 -0.3 -0.3 2.5 0.3 2.8 2.1 2.2
Severe depression (siblings) 0.8 0.8 4.1 0.2 0.0 0.3 -1.1 0.8 0.4 2.0 0.1 1.2
Pack years adult smoking proportion 0.3 0.5 1.7 0.3 0.0 0.3 -0.9 -0.3 -0.6 1.3 0.8 0.7
Impedance of leg (right) 0.1 0.5 2.0 -0.4 0.0 1.4 -0.2 -0.2 1.3 0.5 0.6 0.0
Leg fat-free mass (left) 0.1 0.4 1.4 -0.5 0.0 -1.2 -0.1 -0.2 -0.8 -0.5 -0.7 -0.7
Trunk fat percentage 0.3 1.4 3.8 1.2 0.0 -1.8 0.6 0.8 -0.8 1.3 2.0 0.7
Hand grip strength (right) 1.3 3.5 8.1 -2.8 0.0 -0.4 -1.6 -2.0 1.2 -2.2 -2.3 -2.2
Townsend deprivation index at recruitment 1.0 1.4 5.7 0.5 0.0 0.7 2.1 -0.2 -0.6 1.1 2.4 -0.2
Current tobacco smoking 0.2 0.3 1.6 0.1 0.0 -0.3 -0.2 0.0 -0.0 1.3 0.5 0.5
Average weekly fortified wine intake 0.3 0.4 2.0 -0.1 0.0 0.9 1.4 -0.2 -0.1 -0.6 0.2 -0.5
Maternal smoking around birth 0.5 0.7 2.9 -0.7 0.0 -0.3 0.3 -0.5 -1.7 -1.0 0.6 -0.9
Fed-up feelings 0.6 1.0 2.6 0.8 0.0 0.7 -0.0 0.2 1.5 1.6 1.5 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.5 -0.5 0.0 0.7 -0.5 -0.7 0.6 0.6 -0.3 -0.1
Relative age voice broke 1.8 2.8 7.2 -2.1 0.0 1.1 1.2 -2.2 -0.0 -2.7 -1.1 -2.2
Taking other prescription medications 0.7 1.0 6.3 0.8 0.0 -0.2 2.5 0.5 -0.9 -0.8 0.7 -0.2
Age when periods started (menarche) 2.0 4.9 13.8 -3.7 0.0 -0.2 -2.3 -3.5 -0.1 -1.9 -1.6 -2.4
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.2 0.9 0.0 -0.1 -0.7 1.3 -1.4 1.4 0.4 1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 7.6 0.0 0.0 -1.0 -1.6 1.5 -0.9 -0.6 -2.8 0.5
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 4.0 -2.0 0.0 -1.9 0.8 -1.7 -0.8 -1.6 -1.0 -1.9
Qualifications: CSEs or equivalent 0.2 0.3 1.2 0.4 0.0 1.0 1.1 -0.4 0.3 -0.5 0.2 0.1
Serious illness, injury or assault to yourself 0.5 0.6 2.7 0.6 0.0 -0.4 0.7 1.6 0.8 0.3 -0.9 0.2
High blood pressure 0.4 1.2 5.6 -1.0 0.0 -0.9 -0.3 -1.1 -2.4 -0.3 -1.0 -1.0
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.4 -0.3 0.0 1.1 0.1 0.4 0.4 -1.2 -1.1 -0.4
Multivitamins +/- minerals 1.0 1.2 3.1 0.8 0.0 0.3 -1.0 1.6 1.7 1.5 1.1 0.7
Stomach or abdominal pain in last month 0.6 0.7 2.9 -0.2 0.0 0.5 1.0 -0.3 -0.6 -1.7 -1.3 -0.5
Supplements: Glucosamine 0.3 0.4 1.4 0.0 0.0 -0.7 0.2 1.0 1.2 0.4 -0.0 0.1
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 9.1 1.4 0.0 0.3 -0.3 1.9 -3.0 0.5 -1.9 0.6
Medication: Atenolol 0.3 0.4 1.9 0.2 0.0 -1.4 0.2 -0.2 -0.3 -0.4 -1.0 -0.4
Medication: Levothyroxine sodium 0.1 0.2 0.5 0.3 0.0 0.7 -0.3 -0.1 -0.2 -0.7 0.1 0.4
Sitting height 0.1 0.4 1.0 -0.8 0.0 0.2 -0.3 -0.1 0.4 -1.0 -1.0 -0.7
Chronic bronchitis/emphysema (father) 0.3 0.3 1.6 0.1 0.0 0.4 0.5 -0.6 -0.6 0.0 1.2 -0.0
High blood pressure (mother) 0.5 0.7 3.1 -0.0 0.0 0.7 -1.7 -0.3 -1.5 0.5 -0.5 0.4
Body mass index (BMI) 0.5 2.3 4.4 2.1 0.0 -1.5 -0.3 2.0 -1.0 2.1 1.0 1.9
Impedance of leg (left) 0.2 0.9 4.0 -0.6 0.0 1.5 -0.6 -0.7 2.0 0.3 0.8 -0.1
Leg predicted mass (left) 0.1 0.4 1.4 -0.5 0.0 -1.2 -0.1 -0.2 -0.9 -0.5 -0.7 -0.7
Trunk fat mass 0.2 0.9 3.6 0.9 0.0 -1.9 -0.1 0.6 -0.8 1.1 1.1 0.6
Waist circumference 0.3 1.0 4.3 1.1 0.0 -2.1 -0.1 0.2 -1.5 0.6 1.0 0.5
Number of incorrect matches in round 1.1 1.8 4.0 2.0 0.0 -0.7 0.6 1.7 -1.9 1.1 1.4 1.3
Past tobacco smoking 1.0 1.8 5.6 1.1 0.0 1.7 -1.1 2.4 -0.1 1.2 -1.1 1.6
Alcohol usually taken with meals 0.5 0.8 2.5 0.6 0.0 1.1 -0.8 1.6 1.0 0.9 -0.2 0.9
Nervous feelings 0.4 0.7 1.9 -0.2 0.0 1.0 -1.3 0.4 0.9 1.4 0.5 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.5 -1.5 0.0 0.5 -0.5 -1.3 0.2 -1.6 -1.1 -1.3
Hearing difficulty/problems with background noise 0.2 0.4 1.3 -0.4 0.0 -0.2 0.6 -1.2 0.8 -0.3 0.6 -0.5
Hair/balding pattern: Pattern 2 0.6 0.8 3.0 0.4 0.0 -0.9 1.7 0.3 0.1 0.5 1.7 -0.2
Had menopause 1.5 1.9 5.9 1.3 0.0 1.4 0.5 0.3 0.9 2.2 2.4 1.4
Had other major operations 1.7 2.1 6.4 1.9 0.0 -1.3 -1.3 2.5 -0.0 0.8 -0.2 2.2
Forced vital capacity (FVC) 1.2 4.7 13.0 -2.8 0.0 -0.6 0.6 -2.0 1.1 -3.6 -2.6 -2.9
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 5.8 -0.2 0.0 -1.4 -1.0 0.7 -1.5 -0.8 -2.4 0.2
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 3.0 -1.4 0.0 0.6 -0.4 -0.9 1.7 -0.1 -0.4 -0.5
Qualifications: None of the above 0.9 1.9 8.2 -1.1 0.0 -2.9 0.3 -1.7 -1.4 -0.6 0.9 -1.4
Financial difficulties in last 2 years 0.7 0.9 2.7 1.1 0.0 -0.6 0.8 0.2 1.1 1.1 1.6 0.7
Mouth/teeth dental problems 0.3 0.4 1.7 -0.1 0.0 0.3 0.7 -0.0 1.3 -1.0 0.3 -0.6
Heart attack 0.8 1.0 2.8 1.7 0.0 -1.1 0.5 1.2 -1.3 0.6 0.4 0.9
Allergy 0.4 0.9 3.6 0.5 0.0 -0.9 -1.1 0.5 -0.6 1.9 0.3 1.1
Pain all over the body in last month 0.6 0.6 1.7 -0.6 0.0 -0.1 1.3 -0.7 -0.1 -1.2 0.1 -1.2
Diabetes (self-reported) 0.2 0.3 1.9 0.5 0.0 0.1 1.4 0.2 0.1 0.5 -0.0 0.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.1 0.4 0.0 1.5 -0.2 0.6 0.4 0.8 -0.2 0.9
Medication: Ramipril 0.8 1.0 5.2 -0.2 0.0 -0.5 -0.6 0.1 -2.3 -0.4 -1.7 -0.0
Medication: Simvastatin 0.4 0.5 2.2 0.5 0.0 -1.5 -0.5 0.0 -0.8 -0.5 -1.0 0.4
Fluid intelligence score 1.2 2.5 6.2 1.3 0.0 1.1 -1.4 1.7 1.5 2.5 1.1 2.2
Illnesses of siblings 0.9 1.3 7.1 0.7 0.0 0.8 0.6 0.0 2.7 -0.1 1.6 0.5
Neuroticism score 0.3 0.6 2.4 -0.9 0.0 0.3 -0.9 -1.6 0.4 0.4 0.7 -0.4
Weight 0.1 0.5 2.6 0.3 0.0 -1.6 -0.6 0.7 -0.7 0.8 0.1 0.2
Impedance of arm (right) 0.4 2.1 4.4 -1.7 0.0 0.6 1.2 -2.1 0.6 -1.7 1.4 -2.1
Arm fat percentage (right) 0.6 2.3 4.7 2.0 0.0 -1.5 0.4 1.7 -0.6 2.0 2.2 1.5
Trunk fat-free mass 0.2 1.2 5.2 -1.2 0.0 -0.7 -1.7 -0.2 -0.5 -0.5 -2.3 -0.6
Hip circumference 0.5 1.9 5.4 1.4 0.0 -1.1 -1.7 1.7 0.1 2.3 0.5 1.7
Time employed in main current job 2.9 3.3 6.3 -2.0 0.0 -1.7 -0.9 -1.0 -2.5 -2.3 -2.2 -2.2
Alcohol intake versus 10 years previously 1.5 2.3 10.9 1.1 0.0 -0.0 3.3 -0.0 -2.4 -0.2 1.6 -0.3
Father’s age at death 1.2 1.6 3.1 1.8 0.0 0.5 0.6 1.5 1.5 1.5 1.4 1.4
Worrier / anxious feelings 0.1 0.1 0.6 -0.1 0.0 -0.4 -0.5 0.3 -0.8 0.1 -0.1 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.1 1.0 0.0 0.8 -0.2 0.3 0.4 1.1 1.4 0.8
Falls in the last year 1.2 1.6 5.9 1.5 0.0 0.4 0.8 0.6 1.7 1.3 2.4 0.9
Hair/balding pattern: Pattern 3 0.6 1.0 3.2 -0.7 0.0 -1.8 -1.1 -0.1 -0.9 -0.3 -1.6 -0.2
Number of live births 1.9 2.7 6.5 2.6 0.0 0.3 0.0 2.5 -0.6 2.1 0.9 2.4
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 11.4 -2.0 0.0 -0.4 1.2 -1.7 1.4 -3.4 -1.4 -2.4
Pulse rate 0.4 0.6 3.1 0.7 0.0 1.3 0.2 0.5 -1.8 -0.3 0.5 0.3
Happiness 0.4 0.5 1.5 -1.1 0.0 0.7 -1.2 -0.8 0.0 -0.3 -0.7 -0.6
Noisy workplace 0.2 0.2 0.6 -0.1 0.0 0.8 0.2 0.6 0.6 0.7 -0.5 0.4
Qualifications: A levels/AS levels or equivalent 0.9 1.9 8.5 -0.2 0.0 1.3 -2.9 1.1 0.2 0.6 -1.7 1.6
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.0 5.1 -1.3 0.0 -0.2 0.3 -0.7 -1.8 -2.3 -2.0 -1.8
Mouth/teeth dental problems: Dentures 0.4 0.6 3.9 -0.2 0.0 0.5 -0.6 0.0 -2.0 0.8 -0.6 0.3
Asthma 0.5 0.9 2.0 -0.9 0.0 0.6 1.3 -0.9 -0.9 -1.4 0.2 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 2.4 1.1 0.0 1.5 1.2 0.2 -0.4 0.4 0.8 0.6
Medication: Cholesterol lowering 1.1 1.7 3.8 -0.8 0.0 -2.0 0.6 -0.5 -1.6 -1.6 -1.8 -1.2
Depression (self-reported) 0.1 0.1 0.4 -0.0 0.0 0.5 0.2 0.5 0.2 -0.6 -0.4 -0.1
Medication: Lansoprazole 0.3 0.3 0.9 0.1 0.0 -0.6 -0.4 0.3 -0.5 1.0 -0.7 0.6
Prospective memory result 1.4 1.8 5.5 -0.9 0.0 -2.3 -1.3 0.4 -2.2 -0.3 -1.3 -0.9
Lung cancer (father) 1.1 1.3 2.3 -0.1 0.0 -1.4 -1.5 1.2 1.5 1.5 -0.7 0.8
Illnesses of mother 0.3 0.4 1.0 -0.7 0.0 0.1 0.9 -0.3 -0.3 -1.0 -0.4 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.2 11.5 -1.9 0.0 -0.6 0.7 -1.3 1.6 -3.4 -1.9 -2.3
Pulse wave Arterial Stiffness index 1.3 1.5 3.0 1.7 0.0 1.7 -0.3 1.2 1.2 1.2 1.0 1.4
Impedance of arm (left) 0.5 2.3 4.7 -1.6 0.0 0.4 1.8 -2.1 0.3 -1.8 1.7 -2.2
Arm fat mass (right) 0.4 1.5 2.9 1.7 0.0 -1.3 0.1 1.6 -0.5 1.7 1.4 1.3
Trunk predicted mass 0.2 1.2 5.4 -1.2 0.0 -0.8 -1.7 -0.1 -0.5 -0.5 -2.3 -0.6
Standing height 0.5 5.1 13.7 -3.7 0.0 -0.1 -0.9 -2.7 0.7 -2.8 -2.1 -3.3
Length of working week for main job 0.5 0.5 1.4 0.1 0.0 0.0 -1.1 0.3 1.2 -1.1 -1.0 0.2
Exposure to tobacco smoke at home 1.2 1.3 3.1 1.4 0.0 1.7 1.8 0.5 0.8 -0.5 1.6 0.4
Breastfed as a baby 0.5 0.6 1.8 -0.4 0.0 -0.3 1.3 -1.2 0.3 -0.2 1.2 -0.7
Tense / ‘highly strung’ 0.6 1.1 2.9 -1.4 0.0 0.5 -1.7 -1.0 -1.2 -0.5 -0.9 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.4 -0.8 0.0 -0.4 1.1 -0.9 -0.3 -1.6 0.2 -1.2
Hair/balding pattern: Pattern 4 0.4 0.9 2.3 -0.3 0.0 1.4 0.2 -0.6 -0.8 -1.5 -1.3 -0.8
Birth weight of first child 0.8 1.4 7.4 -0.6 0.0 -0.5 -2.7 0.8 -0.5 0.9 -1.8 0.2
Peak expiratory flow (PEF) 2.1 4.9 10.2 -2.5 0.0 -1.5 2.5 -2.8 -1.3 -3.2 -1.0 -2.9
Pulse wave reflection index 0.4 0.5 1.9 0.2 0.0 0.1 -1.2 1.0 1.4 0.6 -0.1 0.4
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.1 -0.2 0.0 -0.0 0.3 -0.2 1.0 -1.0 -0.1 -0.7
Loud music exposure frequency 1.4 1.5 7.1 0.5 0.0 -0.5 2.7 -0.3 -1.5 -1.0 1.4 -1.0
Qualifications: O levels/GCSEs or equivalent 3.6 5.7 11.4 2.5 0.0 3.3 -2.5 2.3 1.4 2.9 1.0 3.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.8 0.9 0.0 0.3 0.5 0.3 -0.6 0.2 0.2 0.8
Blood clot in the leg (DVT) 0.2 0.2 1.3 0.1 0.0 0.1 0.4 -0.4 1.1 -0.1 -0.3 -0.3
Medication: Paracetamol 0.3 0.5 3.0 0.1 0.0 -0.4 1.7 -0.2 -0.7 -0.5 0.2 -0.6
Headache pain in last month 0.5 0.9 5.2 0.9 0.0 0.3 2.3 0.7 0.3 -0.5 0.9 0.0
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 5.1 -0.2 0.0 2.3 -1.0 0.1 0.6 0.8 0.5 0.6
Glaucoma (self-reported) 0.4 0.5 1.6 -0.9 0.0 -0.3 -0.8 -0.4 0.5 -1.3 -0.2 -0.7
Gout (self-reported) 0.3 0.4 1.0 -0.1 0.0 0.8 -0.6 -0.8 -0.9 -1.0 0.6 0.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.6 0.2 0.0 0.7 -1.2 0.2 1.3 0.3 0.4 0.9
Medication: Amlodipine 0.1 0.1 0.4 -0.2 0.0 0.4 0.1 -0.6 0.4 -0.3 -0.2 -0.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.5 -0.1 0.0 -0.2 1.2 -0.3 -0.5 -0.9 0.5 -0.7
Birth weight 1.2 2.7 4.8 -1.7 0.0 -2.1 0.2 -2.1 -1.9 -1.5 -1.4 -2.2
Chronic bronchitis/emphysema (mother) 1.1 1.2 3.7 1.4 0.0 0.5 -0.6 1.9 1.2 0.4 0.4 1.8
High blood pressure (siblings) 1.2 1.7 5.7 -0.5 0.0 -0.1 -2.0 -0.4 -2.2 0.2 -2.4 0.4
Forced vital capacity (FVC), Best measure 1.1 3.9 12.8 -2.2 0.0 -0.8 0.7 -1.2 0.7 -3.6 -2.8 -2.6
Body fat percentage 0.5 2.0 4.2 1.7 0.0 -1.6 0.2 1.3 -0.6 2.0 2.0 1.3
Leg fat percentage (right) 1.2 4.2 11.1 2.7 0.0 -1.0 -0.7 2.5 -0.0 3.3 2.1 2.6
Arm fat-free mass (right) 0.1 0.6 2.9 -0.5 0.0 -1.1 -1.1 0.1 -0.3 -0.0 -1.7 -0.2
Exposure to tobacco smoke outside home 0.4 0.5 1.7 0.9 0.0 1.0 0.6 0.1 -0.3 0.4 1.3 0.8
Comparative body size at age 10 0.5 1.5 2.9 1.7 0.0 -1.1 -0.3 1.2 1.0 1.6 1.7 1.1
Number of full brothers 1.0 1.2 3.1 -1.0 0.0 0.0 1.4 -1.8 -1.2 -0.5 1.4 -1.2
Worry too long after embarrassment 1.9 3.2 8.1 -2.8 0.0 -0.3 -2.5 -2.8 0.4 -1.5 -0.1 -2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.5 -0.2 0.0 0.3 -0.4 0.3 0.7 0.3 -0.5 0.4
Wheeze or whistling in the chest in last year 0.4 0.6 2.4 -0.6 0.0 0.6 0.3 -1.1 -0.5 -0.1 1.5 -1.0
Number of children fathered 0.5 0.5 1.6 -0.5 0.0 -1.1 0.3 0.4 -1.3 -0.5 0.2 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.6 6.9 1.8 0.0 0.7 -0.0 2.2 1.1 2.6 1.0 2.3
Age at first live birth 1.0 1.7 5.9 -2.4 0.0 -0.4 -1.2 -0.9 1.1 -0.9 -1.6 -1.7
Pulse wave peak to peak time 1.6 1.9 3.8 -2.0 0.0 -1.8 0.3 -1.5 -1.1 -1.4 -1.2 -1.7
Health satisfaction 1.1 1.5 3.4 -0.9 0.0 -0.7 1.3 -1.4 -1.4 -1.7 -0.3 -1.8
Shortness of breath walking on level ground 0.4 0.4 2.0 0.3 0.0 -0.8 0.0 0.9 -1.4 0.1 -0.5 0.0
Qualifications: College or University degree 0.4 1.1 4.3 -1.4 0.0 -0.4 -0.8 -0.3 1.2 -0.8 -2.1 -0.8
Eye problems/disorders: None of the above 2.2 2.6 7.7 1.3 0.0 1.0 -1.7 0.5 2.2 2.8 0.7 2.1
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.4 -0.6 0.0 1.2 0.2 -1.2 -0.2 -0.3 0.4 -0.5
Emphysema/chronic bronchitis 0.6 0.7 3.8 0.4 0.0 0.8 0.9 -0.8 0.4 -0.5 1.9 -0.0
Medication for pain relief, constipation, heartburn 0.7 1.2 4.2 -0.8 0.0 1.1 -1.9 -1.0 2.1 0.6 -0.0 0.3
Neck or shoulder pain in last month 0.5 0.7 3.2 0.5 0.0 0.1 -1.1 0.8 -0.3 1.8 -0.7 0.6
Medication: Blood pressure 0.3 0.6 1.7 1.3 0.0 -1.2 0.2 1.1 -0.1 0.2 -0.1 0.8
Angina (self-reported) 0.6 0.8 2.7 -0.7 0.0 -1.6 -0.7 0.4 -0.8 -0.2 -1.5 -0.6
Migraine (self-reported) 0.8 1.0 4.1 1.6 0.0 0.1 0.7 1.1 2.0 -0.3 0.0 0.9
Medication: Ibuprofen 1.1 1.3 3.2 1.7 0.0 1.8 1.1 0.7 0.6 0.7 1.0 1.3
Medication: Allopurinol 0.3 0.4 1.6 0.4 0.0 -0.6 -1.3 0.2 -0.9 0.1 0.1 0.8
Medication: Omeprazole 1.2 1.4 8.6 -0.2 0.0 -0.9 -0.2 0.8 -2.9 -0.6 -1.4 -0.8
Medication: Seretide 50 evohaler 0.8 0.9 3.4 -0.5 0.0 0.2 1.9 -0.5 -1.2 -1.2 0.1 -1.2
Mean time to correctly identify matches 0.4 0.7 2.5 -0.5 0.0 -1.6 -0.2 -0.7 -1.4 -0.3 0.2 -0.9
Heart disease (mother) 0.2 0.2 1.2 0.1 0.0 -1.1 -0.0 -0.2 0.6 -0.4 -0.2 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 1.1 -0.2 0.0 0.8 0.7 -1.1 0.1 -0.0 0.0 -0.1
Whole body fat mass 0.3 1.3 2.5 1.4 0.0 -1.6 -0.1 1.1 -0.5 1.6 1.6 1.0
Leg fat mass (right) 0.6 2.2 5.2 2.1 0.0 -1.0 -0.5 1.7 -0.3 2.3 1.6 1.9
Arm predicted mass (right) 0.1 0.6 2.6 -0.3 0.0 -1.0 -1.2 0.4 -0.2 0.2 -1.6 0.1
Pulse rate, automated reading 0.4 1.2 4.7 -0.0 0.0 2.1 0.7 -0.8 -2.2 -0.1 0.6 -0.3
Alcohol intake frequency. 0.4 0.9 2.3 1.0 0.0 0.5 1.3 1.5 -1.5 -0.4 -0.7 0.3
Comparative height size at age 10 0.1 0.8 2.6 -0.4 0.0 -1.4 -0.2 0.1 -0.6 -1.1 -1.6 -1.0
Number of full sisters 0.6 0.8 2.0 1.1 0.0 1.0 -0.1 1.0 0.4 1.4 0.8 1.0
Suffer from ‘nerves’ 0.4 0.7 2.8 0.0 0.0 1.0 -0.7 -0.2 1.3 0.4 1.7 0.3
Overall health rating 0.2 0.4 2.3 -0.3 0.0 0.3 0.5 -0.9 -1.5 0.0 -0.4 -0.5
Chest pain or discomfort 0.9 1.3 4.4 1.2 0.0 -0.5 -0.7 1.5 0.7 2.1 -0.1 1.5
Had major operations 0.3 0.4 1.4 0.2 0.0 0.2 0.3 1.2 -0.7 0.4 -1.0 0.5
Age at last live birth 0.5 0.7 2.0 -1.0 0.0 0.6 -0.9 0.3 1.3 0.4 -1.4 -0.4
Family relationship satisfaction 0.3 0.3 1.0 -0.4 0.0 -0.1 -0.5 0.5 -0.7 -1.0 -0.8 -0.3
Leg pain on walking 1.1 1.3 2.5 -1.5 0.0 -1.4 -0.9 -0.3 -1.6 -0.9 -1.6 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 3.0 1.0 0.0 0.7 1.4 1.7 0.4 -0.2 -0.7 0.6
Commuting to job workplace: Car/motor vehicle 0.9 1.1 3.6 -1.3 0.0 1.1 -0.6 -1.9 0.7 -0.8 -1.1 -0.6
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.9 -0.5 0.0 -1.1 -0.7 -1.4 0.1 0.5 1.2 -0.1
Medication: Aspirin 0.5 0.6 2.7 1.1 0.0 -1.7 1.1 0.5 -0.5 -0.3 -0.0 0.4
Supplements: Vitamin C 0.6 0.7 2.5 0.6 0.0 -0.4 0.5 1.6 1.0 0.8 1.0 0.5
Knee pain experienced in last month 0.6 1.0 2.6 -1.6 0.0 -0.0 -0.1 -0.9 -1.6 -0.6 -0.2 -1.6
Hypertension (Self-reported) 0.4 1.1 5.4 -0.9 0.0 -0.6 -0.8 -0.9 -2.3 0.0 -1.3 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 3.4 -0.3 0.0 0.4 -0.5 0.4 -1.8 -0.3 -1.0 -0.4
Illnesses of father: Heart disease 0.2 0.2 0.7 -0.3 0.0 0.2 -0.5 -0.4 -0.9 -0.7 -0.4 -0.1
Illnesses of siblings: Diabetes 0.4 0.5 1.7 1.3 0.0 -0.2 0.1 0.9 -0.8 0.8 0.4 0.9
Smoking status: Previous 1.2 1.7 5.7 -1.1 0.0 -1.4 1.0 -2.4 -0.5 -1.3 1.1 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.9 0.2 0.0 0.9 -0.6 0.6 1.4 0.7 -0.2 0.7
Whole body fat-free mass 0.1 0.7 2.9 -0.9 0.0 -0.9 -1.1 -0.1 -0.6 -0.5 -1.7 -0.6
Leg fat-free mass (right) 0.1 0.3 0.8 -0.6 0.0 -0.9 -0.3 -0.4 -0.5 -0.6 -0.6 -0.8
Arm fat percentage (left) 0.6 2.4 5.5 2.1 0.0 -1.5 0.6 1.6 -0.6 1.9 2.3 1.4
Average weekly red wine intake 0.2 0.3 1.1 -0.5 0.0 -0.5 -0.2 1.0 -0.9 -0.2 -0.2 -0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.5 -0.5 0.0 0.4 -1.0 -0.6 -1.1 -0.3 -1.2 -0.3
Mood swings 0.5 0.9 6.3 -0.7 0.0 -2.5 -0.4 -0.9 0.3 -0.1 -0.2 -0.5
Loneliness, isolation 0.6 0.8 1.9 0.9 0.0 0.8 0.9 1.2 1.4 0.8 0.4 0.6
Long-standing illness, disability or infirmity 0.4 0.6 3.4 0.0 0.0 -0.2 1.2 0.3 -1.8 -0.7 0.1 -0.2
Ever had bowel cancer screening 1.1 1.3 2.6 -1.6 0.0 -1.5 -0.5 -1.1 -1.1 -0.9 -1.4 -1.3
Diabetes diagnosed by doctor 0.1 0.2 0.9 -0.2 0.0 -0.1 0.7 -0.2 -1.0 0.2 -0.5 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 3.5 0.5 0.0 0.6 -0.7 -0.0 -0.2 1.9 1.3 0.9
Friendships satisfaction 0.8 0.9 3.8 -0.4 0.0 0.9 -2.0 0.4 0.0 -0.7 -1.7 0.1
Qualifications: nursing, teaching 0.6 0.9 2.2 -1.5 0.0 0.1 0.0 -1.4 -0.3 -1.2 -0.7 -1.3
Commuting to job workplace: Walk 1.0 1.1 2.7 1.3 0.0 1.6 0.6 0.7 -1.6 -0.3 1.2 0.5
Eye problems/disorders: Cataract 1.0 1.1 3.4 -0.0 0.0 -1.4 1.3 0.3 -1.8 -1.3 -0.7 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.9 0.6 0.0 -0.2 -1.6 1.7 0.2 1.0 -0.9 1.0
Medication for cholesterol 0.3 0.5 1.3 -0.7 0.0 -1.2 -0.3 -0.5 0.6 -1.0 0.4 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.8 0.6 0.0 -0.7 0.6 0.9 -1.7 0.3 0.7 -0.1
Back pain experienced in last month 0.7 1.0 3.3 0.4 0.0 1.4 1.6 -0.8 -1.8 -0.7 0.4 -0.2
Mineral and other dietary supplements 1.2 1.6 4.9 1.8 0.0 1.5 -1.4 0.7 0.3 1.0 1.0 2.2
Breast cancer (self-reported) 0.5 0.6 1.9 -0.9 0.0 -0.0 0.3 0.2 0.3 -1.2 -1.4 -1.2
Asthma (self-reported) 0.6 1.3 3.1 -1.1 0.0 0.5 1.5 -1.1 -0.8 -1.7 0.1 -1.7
Osteoporosis (self-reported) 2.5 3.1 10.1 -2.0 0.0 1.1 0.4 -2.1 -0.1 -3.2 -1.1 -2.7
Osteoarthritis (self-reported) 0.5 0.6 2.6 -0.2 0.0 -0.9 1.6 0.2 -1.0 -0.3 0.4 -0.9
Medication: Aspirin 0.6 0.8 3.7 1.3 0.0 -1.9 0.6 0.9 -0.2 0.4 0.1 0.8
Medication: Gliclazide 0.3 0.4 1.7 0.3 0.0 0.4 -0.2 0.9 0.3 1.3 -0.6 0.5
Illnesses of father: None of the above (group 1) 0.1 0.1 0.6 -0.5 0.0 -0.2 -0.3 0.1 0.1 0.3 -0.7 -0.2
Smoking status: Current 0.2 0.4 1.8 0.5 0.0 0.0 -0.2 0.4 0.5 1.4 0.4 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 6.8 -1.2 0.0 -0.6 1.9 -1.5 1.8 -2.6 0.1 -1.9
Whole body water mass 0.1 0.8 3.3 -0.9 0.0 -1.0 -1.2 -0.1 -0.7 -0.5 -1.8 -0.6
Leg predicted mass (right) 0.1 0.3 0.9 -0.6 0.0 -0.9 -0.2 -0.5 -0.5 -0.6 -0.5 -0.8
Arm fat mass (left) 0.4 1.4 2.5 1.5 0.0 -1.6 0.2 1.5 -0.6 1.6 1.3 1.2
Number of self-reported non-cancer illnesses 1.6 2.8 10.4 -0.2 0.0 -1.1 2.3 -0.2 -3.2 -2.3 -0.9 -1.5
Average weekly champagne plus white wine intake 0.3 0.4 1.3 0.3 0.0 0.9 -0.8 0.5 0.7 1.1 0.1 0.7
Miserableness 0.3 0.6 2.5 -0.0 0.0 0.6 0.4 -0.2 1.0 1.1 1.6 0.2
Guilty feelings 0.4 0.6 2.1 -0.8 0.0 -0.2 -0.7 -1.4 -1.2 -0.5 -0.1 -0.6
Wears glasses or contact lenses 0.6 0.7 2.0 -0.9 0.0 0.1 0.6 -1.1 -1.4 -0.9 -0.3 -1.0
Ever taken oral contraceptive pill 0.9 1.0 2.3 -0.7 0.0 1.1 1.2 -0.8 -0.9 -1.2 0.7 -1.5
Hearing aid user 0.6 0.7 2.0 1.4 0.0 0.8 0.3 1.1 -0.2 0.5 0.6 1.3
Mother’s age at death 0.4 0.4 1.2 -0.8 0.0 -0.1 -0.8 0.4 -1.1 1.1 -0.5 0.1
Financial situation satisfaction 1.2 1.5 4.3 -1.3 0.0 1.0 1.7 -2.1 0.4 -1.3 0.2 -1.3
Tinnitus: Yes, now most or all of the time 1.0 1.1 3.3 1.4 0.0 0.2 -0.5 1.4 0.7 1.8 0.9 1.2
Commuting to job workplace: Public transport 0.2 0.2 0.9 0.5 0.0 -0.9 -0.4 0.2 -0.6 -0.1 0.6 -0.3
Eye problems/disorders: Glaucoma 0.5 0.6 1.7 -0.1 0.0 0.2 1.0 -0.8 0.4 -1.1 1.3 -0.7
Medication: Blood pressure 0.3 0.6 1.7 -0.8 0.0 -0.3 -0.6 -0.8 -1.3 0.6 -1.0 -0.4
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.9 0.6 0.0 0.5 -0.9 0.9 -0.9 -0.0 -0.0 0.8
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.2 -1.3 0.0 -1.4 1.0 -0.8 -0.2 -0.0 -0.2 -1.5
High cholesterol (Self-reported) 0.6 1.0 3.7 0.1 0.0 -0.1 0.9 -0.1 -1.9 -1.6 -1.3 -0.5
Medication: Bendroflumethiazide 0.4 0.7 1.5 1.2 0.0 0.1 0.0 1.1 0.6 1.2 0.3 1.2
Medication: Paracetamol 0.3 0.5 3.3 0.7 0.0 0.2 1.8 0.0 0.2 -0.3 0.9 0.1
Medication: Lisinopril 1.4 1.8 4.2 1.3 0.0 0.6 -1.2 2.0 1.4 1.8 0.3 1.6
Medication: Atorvastatin 0.9 1.1 4.5 -0.2 0.0 0.6 -0.1 0.4 -2.1 -0.3 -2.1 0.1
Illnesses of father: High blood pressure 0.3 0.4 0.9 0.4 0.0 -0.5 -0.4 1.0 0.6 0.8 0.0 1.0
Alcohol drinker status: Never 0.3 0.3 1.4 0.5 0.0 0.4 1.2 0.1 0.9 -0.2 0.6 0.1
Ever smoked 1.1 1.9 5.6 -1.3 0.0 -1.5 1.2 -2.4 0.3 -1.2 1.2 -1.7
Basal metabolic rate 0.1 0.5 1.3 -0.5 0.0 -1.1 -0.9 0.1 -0.6 -0.1 -1.1 -0.3
Leg fat percentage (left) 0.9 3.4 8.9 2.4 0.0 -1.0 -0.9 2.1 0.2 3.0 2.0 2.3
Arm fat-free mass (left) 0.1 0.6 2.1 -0.4 0.0 -0.8 -1.3 0.6 0.0 0.4 -1.5 0.2
Number of operations (self-reported) 1.4 2.0 6.7 0.7 0.0 -2.2 -0.8 2.6 -1.6 0.5 -1.3 1.1
Average weekly beer plus cider intake 0.5 0.8 4.1 0.2 0.0 -2.0 -0.1 0.6 -0.1 1.6 -0.3 0.2
Irritability 0.2 0.4 1.9 -0.7 0.0 -0.1 0.5 -1.4 0.2 -0.0 0.3 -0.6
Risk taking 0.3 0.4 1.5 -0.5 0.0 -1.2 0.5 -0.1 -0.8 -0.8 -0.1 -0.6
Ever had prostate specific antigen (PSA) test 2.5 2.9 6.7 -2.2 0.0 -0.8 -1.8 -1.7 -1.7 -1.6 -2.6 -1.5
Fractured/broken bones in last 5 years 0.6 0.8 2.3 -1.2 0.0 -0.2 -0.1 -1.2 0.2 -1.5 0.2 -1.5
Age started oral contraceptive pill 1.5 1.8 6.4 -1.3 0.0 -1.3 0.2 -1.1 -2.5 -1.5 -1.2 -1.3
Diastolic blood pressure, automated reading 0.2 0.6 1.8 0.6 0.0 0.3 -0.8 0.4 -0.6 1.1 1.3 0.9
Ever depressed for a whole week 0.4 0.5 2.3 -0.8 0.0 0.1 -0.8 -0.1 1.5 0.3 -0.6 -0.3
Unable to work because of sickness or disability 0.2 0.2 0.8 0.1 0.0 0.9 -0.1 0.0 -0.8 -0.2 0.7 -0.2
Commuting to job workplace: Cycle 0.4 0.5 1.0 -1.0 0.0 -0.9 -0.3 -0.6 0.6 -0.5 -1.0 -0.6
Myopia 0.6 0.8 1.8 -1.3 0.0 -1.3 -0.7 -0.6 0.9 -0.0 -1.1 -1.1
Vascular/heart problems diagnosed by doctor 0.4 1.2 5.5 0.8 0.0 1.4 0.1 0.7 2.3 0.4 1.1 0.9
Cholesterol lowering medication 0.6 0.8 3.8 -0.1 0.0 0.6 -0.9 -0.1 -1.3 -0.9 -1.9 0.1
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 5.7 -0.0 0.0 -0.6 -0.2 1.3 -2.4 -0.5 -1.5 -0.6
Pain experienced in last month 1.2 2.0 5.4 1.4 0.0 -0.8 -0.4 1.1 2.3 2.1 1.3 1.5
Supplements: Calcium 0.5 0.6 1.2 -0.9 0.0 0.5 -0.4 -0.5 0.3 -1.1 -1.1 -1.0
Basal cell carcinoma (self-reported) 2.8 3.3 8.6 2.0 0.0 -0.6 -1.4 2.7 0.3 2.9 1.0 2.5
Heart attack/myocardial infarction (self-reported) 1.0 1.3 3.7 1.9 0.0 -1.2 0.7 1.5 -1.1 0.9 0.6 1.2
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 1.2 0.3 0.0 -0.1 0.6 -0.1 1.1 0.0 -0.1 -0.1
Heart disease (siblings) 1.2 1.5 2.8 -1.4 0.0 -0.9 0.9 -1.7 -1.7 -1.0 -0.8 -1.7
Alcohol drinker status: Previous 0.5 0.6 1.8 0.5 0.0 0.6 -0.4 1.1 -0.7 1.3 0.2 0.7
Pack years of smoking 0.4 0.6 2.1 -0.1 0.0 -0.1 -1.0 -0.6 -1.4 1.1 0.7 0.2
Impedance of whole body 0.2 1.2 2.2 -1.0 0.0 1.2 0.9 -1.4 1.3 -0.7 1.5 -1.1
Leg fat mass (left) 0.5 1.8 4.3 1.9 0.0 -1.0 -0.7 1.4 -0.1 2.1 1.5 1.7
Arm predicted mass (left) 0.1 0.6 1.9 -0.1 0.0 -1.1 -1.3 0.7 -0.1 0.5 -1.4 0.4