Hub : Genes

ZNF767

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1480 0.0330 2.7e-11 0.085 0.089 0.109 0.102 0.104 1.5e-10 5.7e-11 3.2e-13 2.3e-12 1.3e-12
2 GTEx Artery Tibial 0.1132 0.0366 1.8e-04 0.006 NA 0.023 NA 0.030 1.0e-01 NA 6.4e-03 NA 2.0e-03
3 GTEx Colon Transverse 0.1850 0.0600 2.2e-04 0.104 NA 0.069 NA 0.082 1.2e-05 NA 3.4e-04 NA 1.0e-04
4 GTEx Esophagus Muscularis 0.1090 0.0480 5.5e-03 0.001 NA 0.005 NA 0.001 2.8e-01 NA 1.6e-01 NA 2.6e-01
5 GTEx Nerve Tibial 0.1667 0.0573 5.0e-04 0.053 NA 0.037 NA 0.047 1.3e-04 NA 1.1e-03 NA 2.9e-04
6 GTEx Skin Sun Exposed Lower leg 0.1010 0.0340 3.2e-04 0.009 NA 0.006 NA 0.020 5.2e-02 NA 8.9e-02 NA 8.4e-03
7 GTEx Spleen 0.3290 0.0940 2.4e-04 0.076 NA 0.055 NA 0.091 5.5e-03 NA 1.6e-02 NA 2.5e-03
8 GTEx Stomach 0.1500 0.0590 3.2e-03 0.093 NA 0.004 NA 0.054 3.4e-05 NA 2.0e-01 NA 1.4e-03
9 GTEx Thyroid 0.1140 0.0360 6.9e-05 0.132 NA 0.122 NA 0.127 2.6e-10 NA 1.4e-09 NA 6.4e-10
10 GTEx Whole Blood 0.0680 0.0300 4.6e-03 0.015 NA 0.003 NA 0.007 1.3e-02 NA 1.7e-01 NA 6.2e-02
11 ROSMAP Brain Pre-frontal Cortex 0.0704 0.0253 1.2e-04 0.010 0.021 0.006 0.019 0.008 1.5e-02 8.0e-04 4.4e-02 1.4e-03 2.5e-02
12 TCGA Cervical Squamous Cell Carcinoma 0.0540 0.0340 9.5e-03 0.019 0.019 0.023 NA 0.025 3.8e-02 3.8e-02 2.6e-02 NA 2.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.2 0.3 2.1 -0.0 0.8 -0.1 -0.5 -0.3 -0.0 -0.5 -0.2 -0.2 0.4 -1.5 -0.5
Bipolar Disorder or Schizophrenia 0.2 0.4 2.4 -1.1 0.4 -0.3 -0.5 -0.3 0.4 -0.1 -0.2 -0.2 -0.1 -1.6 -0.5
Depressed Affect (Nagel 2018) 0.5 1.0 3.9 -0.5 0.0 -0.8 -1.1 -1.0 -1.2 -0.5 -1.0 -1.0 2.0 -0.1 -1.1
Depression (Nagel 2018) 0.4 0.6 1.8 -0.7 0.4 -0.6 -0.9 -0.8 -0.5 -0.1 -0.7 -0.7 1.4 -1.1 -0.9
Intelligence (Savage-Jansen 2018) 1.9 6.0 15.0 2.4 0.7 2.8 2.7 2.4 2.3 2.0 2.3 2.1 -3.9 2.4 2.3
Neuroticism (Nagel 2018) 0.4 0.9 1.9 -0.3 1.2 0.9 0.8 0.9 0.1 1.3 0.9 0.8 1.4 1.3 0.8
Schizophrenia (2018) 0.1 0.3 1.8 -1.3 -0.2 -0.4 -0.2 -0.2 0.6 0.4 -0.1 -0.1 -0.5 -0.8 -0.2
Schizophrenia vs Biploar Disorder 0.5 0.6 1.4 0.2 0.5 0.9 1.1 0.9 0.8 0.6 0.8 0.7 -0.4 1.2 1.0
Worry (Nagel 2018) 2.0 4.2 7.1 0.1 2.1 2.5 2.3 2.4 1.5 2.7 2.3 2.3 -0.3 1.7 2.3
Alzheimer’s Disease (in mother) 0.6 0.7 2.9 -0.1 -0.9 -0.8 -0.8 -0.7 -0.9 -0.6 -0.7 -0.7 0.7 -1.7 -0.7
Alzheimer’s Disease (in father) 0.1 0.2 0.4 -0.4 -0.1 -0.2 -0.4 -0.5 -0.3 -0.6 -0.4 -0.4 0.3 0.0 -0.7
Alzheimer’s Disease (including proxy) 0.4 0.6 2.5 -0.2 -0.7 -0.8 -0.7 -0.7 -0.7 -0.7 -0.9 -0.7 0.5 -1.6 -0.7
Crohns Disease (2017) 3.4 7.5 15.9 3.3 -4.0 -2.9 -2.8 -2.9 -2.4 -2.9 -2.9 -2.9 -0.7 0.2 -2.6
Irritable Bowel Disease (IBD) 1.0 2.3 6.6 2.6 -2.1 -1.3 -1.4 -1.5 -1.3 -1.2 -1.5 -1.5 -0.4 0.8 -1.5
Ulcerative Colitis (UC) 0.2 0.3 1.8 1.4 0.2 0.5 0.2 0.0 0.1 0.4 0.1 0.1 -0.0 1.1 -0.1
Major Depression (MDD) 4.3 5.3 10.7 0.8 2.4 2.4 2.3 2.4 2.4 3.3 2.5 2.4 -1.0 2.2 2.4
Reaction Time 1.1 2.2 3.0 -0.4 1.7 1.7 1.6 1.6 1.7 1.4 1.6 1.6 0.1 1.7 1.5
Verbal and Numeric Reasoning (VNR) 0.9 2.2 8.6 2.5 -0.5 1.2 1.1 1.0 1.4 0.6 1.1 1.1 -2.9 1.5 1.0
Breast Cancer 0.3 0.7 1.4 0.7 -1.0 -1.2 -1.0 -1.0 -0.4 -0.4 -0.9 -0.9 0.0 0.4 -1.0
Ovarian Cancer 0.4 0.6 1.9 0.9 -1.4 -0.7 -0.4 -0.5 -1.0 -0.8 -0.6 -0.6 -0.1 0.7 -0.5
Prostate Cancer 0.0 0.0 0.1 -0.4 -0.2 -0.3 -0.3 -0.2 -0.2 -0.2 -0.1 -0.1 -0.0 0.2 -0.2
Age at First Birth 0.1 0.2 0.6 0.5 -0.1 0.2 -0.2 -0.2 -0.7 -0.8 -0.2 -0.2 -0.6 0.2 -0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 5.9 -1.1 0.3 -0.9 -0.9 -1.0 -1.0 -0.8 -0.9 -1.0 2.4 -1.4 -1.1
Coronary Artery Disease (CAD) 0.3 0.3 2.4 1.5 -0.1 0.1 0.1 -0.2 0.0 -0.5 -0.1 -0.3 -0.6 -0.9 -0.4
Crohns Disease (2012) 5.2 8.4 12.8 3.1 -3.6 -3.3 -3.0 -3.1 -3.2 -3.2 -3.3 -3.2 0.6 -0.1 -2.9
Mean Putamen Volume 0.3 0.3 0.9 -1.0 -0.1 -0.3 -0.5 -0.5 -0.6 -0.9 -0.5 -0.5 0.4 -0.5 -0.6
Fasting Glucose 0.3 0.3 2.0 0.2 -0.4 -0.8 -0.5 -0.5 0.2 -0.1 -0.6 -0.6 0.1 -1.4 -0.3
HbA1C 0.8 0.9 1.9 -0.3 0.7 1.0 1.2 1.4 0.8 0.5 1.2 0.9 -0.1 0.8 1.4
HDL Cholesterol 1.0 1.7 2.8 0.4 0.8 1.7 1.6 1.6 0.3 1.2 1.6 1.5 -1.5 0.9 1.5
LDL Cholesterol 1.1 1.8 13.3 -3.6 1.6 0.1 0.3 0.4 -0.4 0.6 0.4 0.3 2.0 -0.5 0.2
Lupus 2.2 3.4 7.1 0.7 -1.6 -1.8 -2.0 -2.2 -1.2 -2.7 -2.3 -2.3 -0.1 -1.5 -2.1
Neuroticism (2016) 1.0 1.4 3.1 -1.4 1.8 1.0 1.1 1.1 1.2 1.4 1.1 1.1 0.9 0.3 1.3
Primary Biliary Cirrhosis 0.3 0.4 2.0 -0.7 0.5 -0.2 -0.4 -0.4 -0.4 -0.0 -0.3 -0.3 0.9 -1.4 -0.4
Rheumatoid Arthritis 1.5 2.1 3.3 0.4 -1.7 -1.8 -1.4 -1.4 -1.8 -1.0 -1.4 -1.4 1.6 -1.3 -1.3
Schizophrenia (2014) 0.4 0.9 3.1 0.1 -1.3 -1.2 -1.1 -1.0 -0.4 -0.4 -0.8 -0.9 -0.3 -1.8 -1.0
Triglycerides 1.0 1.7 7.6 -2.5 0.2 -1.1 -0.5 -0.8 -1.2 -0.2 -0.8 -0.8 2.8 -1.0 -0.8
Type 2 Diabetes (T2D) (2012) 0.3 0.4 2.1 -0.7 0.8 -0.0 0.0 -0.1 0.6 -0.6 -0.6 -0.2 1.4 -0.4 -0.3
Ulcerative Colitis 0.3 0.4 1.2 0.7 -0.4 -0.5 -0.6 -0.7 -1.1 -0.4 -0.6 -0.7 0.6 -0.4 -0.8
Blood Eosinophil Count 0.4 2.8 26.7 -2.2 0.7 0.4 0.3 0.2 -0.6 -0.9 0.2 0.1 -0.5 5.2 0.2
Blood Platelet Count 0.1 1.3 8.3 2.2 0.1 0.6 0.6 0.4 0.5 -0.2 0.4 0.4 -0.6 2.9 0.4
Blood Red Count 0.4 3.9 8.6 2.9 -2.5 -2.3 -2.2 -2.0 -1.3 -1.5 -2.0 -2.1 0.3 -1.4 -2.0
Blood White Count 0.5 3.5 15.5 -3.9 1.9 -0.5 -0.4 -0.4 0.2 0.6 -0.3 -0.4 2.9 -3.6 -0.4
Heel T-Score 0.1 1.0 1.6 0.8 -1.1 -0.9 -1.0 -1.2 -0.3 -1.2 -1.1 -1.2 -1.3 -0.3 -1.1
BMI 0.3 1.5 5.8 -1.3 0.7 -1.0 -0.8 -0.9 -0.5 -0.5 -0.9 -0.8 2.4 -2.2 -0.9
Height 0.3 6.4 16.7 2.2 -3.8 -2.6 -2.3 -2.5 -4.1 -1.7 -2.4 -2.4 0.5 -0.7 -2.7
Waist Hip Ratio (WHR) 0.2 1.0 6.8 -2.6 1.2 0.1 0.2 0.5 0.6 0.5 0.4 0.4 1.2 0.5 0.6
Systolic Blood Pressure 0.2 1.2 5.1 -1.6 -0.3 -1.0 -0.8 -0.8 0.4 -0.7 -0.9 -0.9 1.3 -2.3 -0.5
Smoking Status 0.6 1.4 5.8 -0.3 -0.4 -1.1 -1.0 -0.9 -1.2 -0.1 -0.9 -0.9 1.9 -2.4 -0.8
Allergy or Eczema 1.2 3.1 6.9 2.6 -2.2 -1.1 -1.6 -1.6 -2.1 -2.1 -1.6 -1.5 -1.4 -0.5 -1.8
Cardiovascular Disease 0.3 0.9 4.8 -0.6 1.2 0.1 0.0 0.0 0.3 0.6 0.1 0.1 2.0 -2.2 -0.0
Hypothyroidism (self reported) 1.1 2.5 6.7 -0.1 2.5 1.7 1.3 1.2 1.9 2.6 1.3 1.3 0.3 -1.6 1.2
Respiratory disease 1.3 2.8 3.7 -0.4 -1.7 -1.9 -1.9 -1.8 -1.9 -1.9 -1.8 -1.8 0.6 -1.6 -1.9
Type 2 Diabetes (T2D) (2018) 1.1 2.0 11.6 -3.2 1.0 -0.5 -0.0 0.1 -0.9 0.4 0.2 0.2 3.4 -0.9 -0.1
Lung FEV1/FVC ratio 0.3 1.5 2.8 0.7 -1.2 -1.2 -1.4 -1.4 -0.6 -1.7 -1.4 -1.5 0.3 -1.4 -1.2
Lung FVC 0.4 1.9 2.6 1.6 -1.6 -1.4 -1.5 -1.5 -1.0 -1.4 -1.5 -1.5 0.2 1.0 -1.6
Neuroticism 0.8 2.0 4.1 -1.0 2.0 1.4 1.4 1.5 0.4 2.0 1.4 1.4 1.5 0.9 1.4
Chronotype (morning person) 0.8 1.9 9.6 -1.5 2.1 0.1 0.1 0.4 -0.2 1.9 0.3 0.3 3.1 -1.4 0.2
Hair Pigment 0.0 0.2 1.3 1.1 -0.3 0.3 0.4 0.1 -0.2 -0.1 0.4 0.3 -0.2 0.3 -0.4
Tanning 0.1 0.6 1.4 1.2 -1.2 -0.8 -0.7 -0.6 -0.7 -0.7 -0.7 -0.6 -0.6 -0.7 -0.6
Hand grip strength (left) 0.5 1.2 6.9 2.6 -1.1 -0.3 -0.5 -0.4 -0.8 -0.3 -0.2 -0.2 -1.8 1.1 -0.8
Number of treatments/medications taken 0.3 0.5 3.0 -1.5 0.0 -0.3 -0.3 -0.2 -0.2 -0.2 -0.2 -0.2 0.4 -1.7 -0.2
Average weekly spirits intake 0.1 0.1 0.9 -0.4 0.2 -0.1 -0.1 -0.1 -0.4 -0.4 -0.0 0.0 0.2 -1.0 -0.2
Sensitivity / hurt feelings 0.1 0.2 1.5 0.1 0.2 -0.6 -0.3 -0.2 -0.6 0.4 -0.2 -0.2 1.2 -0.6 -0.0
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.6 0.8 -0.3 -1.0 -1.1 -1.0 -0.5 -0.6 -1.1 -1.0 1.2 -1.1 -1.0
Hearing difficulty/problems: Yes 2.2 3.3 5.6 -1.3 1.4 1.8 1.9 2.0 2.4 1.9 2.0 2.0 -1.0 1.8 2.0
Relative age of first facial hair 0.1 0.1 0.6 -0.6 -0.2 -0.2 0.3 0.2 0.0 0.1 0.2 0.2 0.2 0.8 0.2
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 2.7 -1.0 0.9 0.2 -0.2 -0.2 -0.1 0.2 -0.1 -0.1 1.6 -0.6 -0.2
Ever used hormone-replacement therapy (HRT) 2.1 2.7 5.1 0.5 -2.2 -2.0 -1.9 -1.8 -1.2 -2.3 -1.9 -1.9 -0.4 0.0 -1.6
Ever had hysterectomy (womb removed) 0.3 0.4 1.3 0.3 0.1 -0.5 -0.7 -0.6 0.3 -0.1 -0.7 -0.7 0.9 -1.1 -0.5
Systolic blood pressure, automated reading 0.2 0.5 1.5 -1.1 -0.5 -0.7 -0.4 -0.5 0.6 -0.8 -0.6 -0.6 0.4 -1.2 -0.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.5 -0.7 -0.1 -0.0 0.3 0.2 0.1 -0.3 0.3 0.2 0.3 0.3 0.1
Angina 0.1 0.2 0.6 -0.4 -0.4 -0.5 -0.2 -0.2 -0.3 -0.2 -0.1 -0.2 0.8 -0.6 -0.2
Medication for hormone replacement therapy 0.2 0.2 0.9 0.3 -0.5 -0.1 -0.1 -0.2 -0.3 -0.5 -0.2 -0.2 -0.9 0.8 -0.2
Vitamin and mineral supplements 3.9 5.4 8.6 -0.4 2.2 2.3 2.6 2.7 2.9 2.8 2.6 2.6 -1.1 1.1 2.8
Supplements: Zinc 2.3 2.5 4.5 0.2 -1.4 -1.6 -1.6 -1.9 -1.9 -2.1 -1.8 -1.8 1.0 -0.2 -2.0
Medication: Co-codamol 0.1 0.1 1.0 1.0 -0.3 0.3 -0.1 -0.1 0.3 0.1 -0.1 -0.1 -0.7 -0.0 0.0
Medication: Metformin 0.9 1.2 7.7 -2.3 0.9 -0.1 0.1 0.0 -0.9 0.3 0.1 0.0 2.8 -0.3 -0.2
Diabetes (father) 0.3 0.4 0.8 0.2 0.5 0.8 0.8 0.6 0.7 0.9 0.6 0.6 -0.5 0.4 0.6
Diabetes (mother) 0.4 0.5 2.4 -1.6 -0.1 -0.4 -0.4 -0.3 -1.2 -0.3 -0.3 -0.3 0.8 -0.4 -0.4
Severe depression (siblings) 0.5 0.5 0.8 0.5 -0.9 -0.8 -0.8 -0.7 -0.8 -0.9 -0.7 -0.7 0.3 -0.7 -0.7
Pack years adult smoking proportion 1.8 2.8 5.3 -0.5 2.1 1.8 1.8 1.8 2.0 2.3 1.7 1.7 -0.2 0.5 2.0
Impedance of leg (right) 0.2 0.9 5.1 -2.3 -0.4 -0.6 -0.6 -0.6 -1.6 -0.7 -0.6 -0.7 0.8 -0.2 -0.6
Leg fat-free mass (left) 0.2 1.2 4.2 2.0 -1.0 -1.1 -0.9 -1.0 -1.1 -0.3 -0.9 -0.9 0.7 -1.1 -1.1
Trunk fat percentage 0.8 3.3 10.4 -2.5 0.3 -1.5 -1.4 -1.5 -1.3 -1.0 -1.6 -1.5 2.6 -3.2 -1.3
Hand grip strength (right) 0.5 1.3 6.6 2.6 -1.0 0.1 -0.1 -0.1 -0.8 0.5 0.2 0.1 -2.1 1.5 -0.5
Townsend deprivation index at recruitment 0.5 0.7 3.4 1.8 -1.0 -0.6 -0.6 -0.6 -0.9 -0.3 -0.6 -0.6 0.0 -0.2 -0.7
Current tobacco smoking 0.1 0.2 0.7 -0.8 0.8 0.1 -0.0 0.0 -0.4 0.4 0.0 -0.0 0.8 -0.1 0.1
Average weekly fortified wine intake 0.8 0.9 2.8 1.7 -1.7 -0.8 -0.9 -0.8 0.0 -0.8 -0.7 -0.7 -0.9 -0.6 -0.8
Maternal smoking around birth 0.7 1.1 2.7 0.1 1.6 1.4 1.2 0.9 1.0 1.4 0.8 0.9 0.6 0.1 0.9
Fed-up feelings 0.6 1.0 1.7 0.7 -0.9 -1.3 -1.2 -1.1 -1.0 -0.5 -1.2 -1.2 1.2 -0.4 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.3 0.1 -0.5 -1.0 -0.8 -0.6 -0.4 -0.1 -0.6 -0.6 1.1 -0.3 -0.6
Relative age voice broke 0.3 0.4 1.8 -1.3 0.8 0.4 0.6 0.5 0.4 0.4 0.6 0.5 -0.0 -0.6 0.4
Taking other prescription medications 0.1 0.1 1.2 -1.1 0.3 0.1 0.0 0.1 0.4 0.3 0.1 0.2 0.1 -0.2 0.2
Age when periods started (menarche) 0.5 1.2 8.2 -1.5 0.6 -0.5 -0.4 -0.3 -1.4 -0.0 -0.4 -0.4 2.9 -0.6 -0.4
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.4 -1.5 1.4 0.9 0.8 1.0 1.0 0.5 0.8 0.9 0.1 0.4 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.5 -0.2 -0.7 -0.6 -0.5 -0.6 -0.2 -0.7 -0.7 -0.6 -0.7 -0.6 -0.6
Tinnitus: Yes, but not now, but have in the past 2.5 2.7 4.5 0.6 -1.4 -2.0 -1.9 -2.0 -0.4 -1.6 -2.1 -2.1 -0.4 -2.1 -1.6
Qualifications: CSEs or equivalent 1.9 2.5 4.0 0.1 -1.3 -1.7 -1.8 -1.9 -1.5 -1.2 -1.9 -1.9 0.8 -1.8 -2.0
Serious illness, injury or assault to yourself 0.4 0.4 1.5 0.5 0.8 -0.2 -0.8 -0.7 -0.0 0.0 -0.7 -0.6 0.6 -1.2 -0.7
High blood pressure 0.3 0.7 3.6 -1.4 0.8 -0.4 -0.4 -0.4 0.7 -0.1 -0.4 -0.4 1.1 -1.9 -0.3
Hayfever, allergic rhinitis or eczema 1.9 4.1 9.0 3.0 -2.6 -1.6 -2.0 -2.0 -2.3 -2.1 -1.9 -1.9 -0.5 -0.8 -2.2
Multivitamins +/- minerals 0.9 1.1 2.2 0.1 -0.8 -0.8 -1.1 -1.2 -1.5 -1.3 -1.2 -1.2 0.8 -0.3 -1.3
Stomach or abdominal pain in last month 2.7 3.4 7.3 -1.6 -0.7 -1.8 -1.7 -1.8 -2.0 -0.9 -1.8 -1.8 2.7 -2.7 -1.7
Supplements: Glucosamine 1.5 2.0 4.4 -0.7 -1.6 -1.4 -1.5 -1.4 -2.1 -1.9 -1.5 -1.5 0.7 0.2 -1.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.0 -0.2 0.8 0.5 0.3 0.2 0.4 0.4 0.1 0.1 1.0 0.5 0.3
Medication: Atenolol 0.3 0.4 0.9 0.2 0.3 0.5 0.5 0.6 0.6 0.4 0.7 0.7 -0.8 -0.9 0.7
Medication: Levothyroxine sodium 0.4 0.7 2.6 0.3 1.3 0.6 0.3 0.3 1.2 1.2 0.3 0.3 0.6 -1.6 0.1
Sitting height 0.8 5.6 13.0 3.4 -3.6 -2.3 -2.0 -2.1 -3.5 -1.4 -2.0 -2.0 -0.2 -1.4 -2.3
Chronic bronchitis/emphysema (father) 0.4 0.4 1.5 -0.4 1.2 0.8 0.6 0.6 0.6 0.4 0.7 0.7 -0.3 0.5 0.5
High blood pressure (mother) 0.2 0.2 0.7 -0.5 0.6 -0.1 -0.3 -0.3 -0.3 0.4 -0.4 -0.4 0.7 -0.9 -0.0
Body mass index (BMI) 0.8 3.3 8.6 -1.0 -0.2 -1.8 -1.7 -1.8 -1.1 -1.2 -1.9 -1.8 2.9 -2.9 -1.7
Impedance of leg (left) 0.2 1.0 3.4 -1.8 -0.7 -0.7 -0.8 -0.8 -1.9 -1.0 -0.8 -0.9 0.6 -0.4 -0.7
Leg predicted mass (left) 0.2 1.2 4.2 2.0 -0.9 -1.1 -0.9 -1.0 -1.1 -0.3 -1.0 -0.9 0.8 -1.1 -1.2
Trunk fat mass 0.9 3.9 10.2 -1.2 -0.6 -2.0 -1.9 -2.0 -1.8 -1.4 -2.0 -2.0 2.5 -3.2 -2.0
Waist circumference 0.7 2.5 6.7 -1.1 -0.3 -1.8 -1.5 -1.5 -0.7 -1.1 -1.6 -1.6 2.6 -2.4 -1.4
Number of incorrect matches in round 0.9 1.5 5.7 -1.2 -1.0 -1.3 -1.0 -1.1 -0.4 -1.5 -1.1 -1.1 0.3 -2.4 -1.1
Past tobacco smoking 0.6 1.2 4.5 0.6 0.3 1.0 1.0 0.7 1.4 0.0 0.7 0.6 -2.1 1.9 0.7
Alcohol usually taken with meals 0.2 0.4 3.1 -0.5 -0.6 -0.1 -0.1 -0.1 -0.7 0.1 -0.3 -0.2 -0.1 -1.8 -0.1
Nervous feelings 2.3 4.2 5.9 1.4 1.1 2.1 2.2 2.3 2.0 2.3 2.2 2.2 -1.7 2.3 2.4
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.1 0.3 -0.7 -1.0 -1.0 -0.9 -0.6 -0.5 -0.9 -0.9 0.5 -0.4 -0.7
Hearing difficulty/problems with background noise 0.1 0.2 0.7 -0.8 -0.9 -0.4 0.2 0.4 0.3 0.5 0.4 0.4 -0.3 -0.5 0.3
Hair/balding pattern: Pattern 2 10.1 12.9 26.1 2.2 -5.1 -4.7 -4.0 -3.8 -3.3 -4.1 -3.8 -3.8 0.8 -1.4 -3.7
Had menopause 0.1 0.2 1.2 0.3 0.0 0.0 0.1 0.2 0.6 0.0 0.2 0.2 -1.1 -0.3 0.1
Had other major operations 0.6 0.7 3.5 -0.2 -0.6 -0.9 -0.9 -0.8 -0.6 -0.5 -0.7 -0.7 0.5 -1.9 -0.7
Forced vital capacity (FVC) 1.3 5.2 10.6 2.7 -3.2 -2.4 -2.3 -2.2 -2.8 -2.2 -2.2 -2.2 0.1 0.0 -2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.3 -0.2 -1.1 -1.1 -1.1 -1.2 -0.9 -1.5 -1.3 -1.2 -0.2 -1.0 -1.2
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 2.9 -0.5 -0.1 -1.1 -1.4 -1.2 -0.9 -0.5 -1.1 -1.1 1.5 -1.7 -1.2
Qualifications: None of the above 0.6 1.2 3.1 -1.4 1.8 0.6 0.8 1.0 1.6 0.9 0.8 0.8 0.9 0.4 1.3
Financial difficulties in last 2 years 1.9 2.5 3.6 1.9 -1.2 -1.4 -1.7 -1.7 -1.5 -1.1 -1.9 -1.9 1.2 -1.5 -1.6
Mouth/teeth dental problems 0.2 0.3 1.5 -0.2 -0.6 -0.4 -0.4 -0.2 -1.2 -0.1 -0.1 -0.1 0.4 1.0 -0.5
Heart attack 0.1 0.2 0.9 -0.0 -0.4 -0.2 0.1 0.2 -0.3 0.6 0.2 0.2 1.0 -0.0 0.3
Allergy 1.4 3.3 7.6 -2.8 2.2 1.4 1.9 1.8 2.0 1.8 1.7 1.7 0.7 0.8 2.0
Pain all over the body in last month 1.6 1.7 4.6 1.5 -2.1 -1.5 -1.3 -1.3 -1.0 -1.2 -1.3 -1.3 -0.8 -0.8 -1.2
Diabetes (self-reported) 1.0 1.5 7.3 -2.3 0.4 -0.9 -0.5 -0.5 -1.3 -0.4 -0.4 -0.4 2.7 -1.2 -0.7
Hayfever/allergic rhinitis (self-reported) 1.3 1.8 5.0 2.2 -1.7 -1.0 -1.3 -1.3 -1.1 -1.5 -1.2 -1.2 -0.9 -0.2 -1.3
Medication: Ramipril 1.1 1.4 3.9 -2.0 1.8 1.1 1.0 0.8 1.8 0.9 0.8 0.9 0.2 -0.0 1.0
Medication: Simvastatin 1.6 2.4 5.9 -2.3 2.4 1.0 1.2 1.3 1.2 1.5 1.3 1.3 1.5 -1.3 1.4
Fluid intelligence score 0.4 0.8 3.5 1.9 -0.2 0.8 0.6 0.7 0.6 0.6 0.7 0.7 -1.3 1.0 0.7
Illnesses of siblings 1.4 1.9 3.0 -0.6 1.5 1.7 1.7 1.6 1.3 1.2 1.5 1.5 -0.6 1.0 1.7
Neuroticism score 0.5 0.9 3.0 0.3 1.1 0.8 0.9 1.0 0.6 1.7 0.9 0.9 0.9 0.7 1.2
Weight 1.0 5.0 8.1 0.6 -1.6 -2.5 -2.3 -2.5 -2.2 -1.7 -2.5 -2.4 2.3 -2.8 -2.5
Impedance of arm (right) 0.2 0.7 1.4 -1.1 0.8 1.0 0.8 0.9 0.3 0.6 0.9 0.9 -1.2 0.5 0.9
Arm fat percentage (right) 0.8 3.1 10.6 -1.4 0.3 -1.5 -1.5 -1.6 -1.1 -1.2 -1.7 -1.7 2.6 -3.2 -1.5
Trunk fat-free mass 0.7 4.0 9.7 3.1 -2.4 -2.0 -1.9 -2.0 -2.2 -1.4 -2.0 -1.9 0.8 -1.0 -2.4
Hip circumference 1.0 4.2 9.0 0.7 -1.3 -2.3 -2.0 -2.2 -1.7 -1.5 -2.2 -2.2 2.3 -3.0 -2.2
Time employed in main current job 0.3 0.4 1.9 0.3 -0.2 0.4 0.5 0.4 -0.2 -0.2 0.4 0.4 -1.1 1.4 0.4
Alcohol intake versus 10 years previously 3.9 5.8 14.7 -1.1 -1.0 -2.6 -2.6 -2.6 -2.4 -1.7 -2.6 -2.6 2.3 -3.8 -2.4
Father’s age at death 0.1 0.2 0.7 0.1 -0.8 -0.5 -0.2 -0.2 -0.6 -0.5 -0.2 -0.2 -0.0 0.3 -0.3
Worrier / anxious feelings 0.4 0.7 1.6 1.0 -0.7 -0.8 -0.9 -0.8 -0.5 -0.8 -0.8 -0.9 0.3 1.3 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.2 -0.0 -0.9 -0.7 -0.8 -0.9 -0.6 -0.9 -1.0 -1.1 0.3 -1.5 -0.8
Falls in the last year 0.1 0.1 1.2 -1.1 -0.0 0.1 0.1 -0.0 0.2 -0.1 -0.1 -0.1 0.0 -0.0 0.2
Hair/balding pattern: Pattern 3 2.3 3.4 4.8 -0.3 2.0 2.2 2.0 1.9 2.1 2.1 1.9 1.9 -0.8 2.0 2.0
Number of live births 2.3 3.2 7.4 -2.3 2.7 2.1 1.7 1.7 2.0 1.6 1.7 1.8 -0.3 0.5 1.7
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 9.4 2.7 -3.1 -2.1 -2.1 -2.1 -2.7 -2.2 -2.0 -2.0 -0.2 0.2 -2.2
Pulse rate 2.6 4.4 13.8 -2.3 0.3 -1.7 -1.6 -1.6 -2.1 -0.3 -1.7 -1.7 3.5 -3.7 -1.7
Happiness 2.9 3.5 4.5 0.6 1.4 2.1 2.0 2.1 2.0 2.1 2.1 2.1 -1.5 1.6 2.0
Noisy workplace 0.8 1.0 1.6 1.0 -0.9 -1.1 -1.2 -1.2 -0.6 -1.1 -1.2 -1.3 0.2 0.4 -1.1
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.8 0.9 -1.9 -1.2 -1.3 -1.2 -1.6 -1.2 -1.1 -1.1 0.0 -0.9 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.2 -0.1 -0.7 -0.9 -0.9 -0.9 -1.3 -0.6 -0.9 -0.8 1.1 -1.5 -1.1
Mouth/teeth dental problems: Dentures 0.1 0.2 1.2 0.3 1.1 0.2 0.2 0.2 0.8 0.3 0.2 0.2 0.7 -0.2 0.2
Asthma 0.6 1.2 1.8 -0.3 -1.1 -1.1 -1.3 -1.2 -1.2 -1.2 -1.2 -1.2 0.6 -0.6 -1.3
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.1 5.0 -0.9 -1.2 -1.6 -1.8 -1.7 -2.2 -2.0 -1.7 -1.7 1.7 -2.2 -2.0
Medication: Cholesterol lowering 1.2 1.9 4.8 -2.2 2.1 1.2 1.2 1.2 1.2 1.3 1.2 1.2 0.9 -0.6 1.4
Depression (self-reported) 0.2 0.3 1.7 1.3 0.5 0.4 0.2 0.3 0.7 0.6 0.3 0.2 -0.1 0.0 0.3
Medication: Lansoprazole 2.8 3.2 4.7 0.8 -1.8 -1.9 -2.0 -2.2 -1.3 -2.0 -2.2 -2.2 0.9 -1.5 -2.0
Prospective memory result 1.9 2.4 4.7 0.0 -0.7 -1.5 -1.7 -1.7 -1.4 -0.8 -1.7 -1.7 2.0 -2.2 -1.7
Lung cancer (father) 1.0 1.1 3.1 1.5 -0.5 -0.7 -1.1 -1.0 -0.9 -0.9 -1.1 -1.1 0.3 -1.7 -1.0
Illnesses of mother 0.1 0.2 0.3 0.2 -0.4 -0.4 -0.3 -0.3 -0.5 -0.5 -0.3 -0.2 0.6 0.6 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.3 13.2 2.5 -3.6 -2.9 -2.5 -2.5 -2.7 -2.9 -2.5 -2.5 0.1 -0.0 -2.7
Pulse wave Arterial Stiffness index 1.7 2.0 3.0 1.7 -1.4 -1.4 -1.5 -1.6 -1.2 -0.9 -1.6 -1.6 0.1 -1.4 -1.6
Impedance of arm (left) 0.2 1.2 4.0 -2.0 1.5 1.2 0.9 1.1 0.3 0.8 1.0 1.0 -0.4 0.5 1.2
Arm fat mass (right) 0.9 3.8 10.2 -0.7 -0.4 -1.9 -1.8 -2.0 -1.6 -1.3 -2.1 -2.0 2.8 -3.2 -2.0
Trunk predicted mass 0.7 4.0 9.0 3.0 -2.4 -2.0 -1.9 -2.1 -2.2 -1.3 -2.0 -1.9 0.9 -1.1 -2.4
Standing height 0.4 4.3 12.3 3.5 -3.2 -1.7 -1.6 -1.8 -2.8 -1.2 -1.6 -1.6 -1.1 -0.1 -2.1
Length of working week for main job 0.3 0.3 1.6 1.2 -0.7 -0.2 0.0 0.0 -1.1 -0.1 0.1 0.1 0.4 0.2 -0.0
Exposure to tobacco smoke at home 0.8 0.9 1.9 0.4 -0.7 -1.4 -1.2 -1.1 -0.4 -0.6 -1.1 -1.0 1.0 -0.3 -1.1
Breastfed as a baby 1.3 1.6 2.2 0.9 1.0 1.4 1.3 1.4 1.3 1.4 1.4 1.5 -1.2 0.8 1.2
Tense / ‘highly strung’ 0.9 1.6 3.8 -1.4 1.4 1.1 1.4 1.4 0.4 1.9 1.4 1.3 0.5 0.0 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.7 1.3 -0.4 -0.1 -0.2 -0.1 0.2 0.1 -0.1 -0.1 -1.0 0.3 -0.2
Hair/balding pattern: Pattern 4 0.1 0.3 0.6 -0.6 0.8 0.6 0.5 0.5 0.8 0.6 0.5 0.4 -0.2 0.6 0.4
Birth weight of first child 0.5 0.8 3.3 -0.5 -0.3 -1.1 -0.7 -0.4 -1.5 0.5 -0.4 -0.3 1.8 -1.3 -0.5
Peak expiratory flow (PEF) 1.0 2.3 6.7 2.4 -2.6 -1.2 -1.0 -1.1 -2.1 -1.4 -1.1 -1.1 -1.2 0.0 -1.1
Pulse wave reflection index 1.3 1.6 4.1 1.6 0.7 1.4 1.1 1.0 1.6 1.0 1.0 1.1 -2.0 1.0 0.9
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.5 0.1 -0.4 -0.9 -1.0 -0.9 -1.0 -0.4 -0.8 -0.7 1.6 -1.5 -0.9
Loud music exposure frequency 1.7 1.9 3.3 -0.0 -0.6 -1.5 -1.8 -1.7 -0.8 -1.3 -1.8 -1.8 0.9 -1.4 -1.6
Qualifications: O levels/GCSEs or equivalent 2.2 3.6 5.5 1.4 -1.7 -1.6 -2.0 -2.1 -2.3 -2.0 -2.0 -2.0 0.4 -2.0 -2.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.1 0.4 0.0 0.9 0.9 0.9 1.0 0.9 0.9 0.8 -0.6 0.3 1.0
Blood clot in the leg (DVT) 0.9 1.1 2.8 0.6 0.5 1.1 1.1 1.1 0.9 0.7 1.2 1.1 -1.1 1.7 1.1
Medication: Paracetamol 3.7 6.1 11.3 -0.7 -1.5 -2.8 -2.5 -2.5 -2.7 -2.1 -2.6 -2.6 2.8 -3.4 -2.4
Headache pain in last month 0.2 0.4 1.4 -0.1 1.2 0.7 0.5 0.5 -0.1 0.9 0.5 0.5 0.4 -0.9 0.5
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 5.3 1.5 -2.3 -1.9 -1.9 -1.8 -2.1 -1.9 -1.9 -1.8 0.0 0.3 -1.9
Glaucoma (self-reported) 2.2 2.6 4.5 -1.7 2.1 1.6 1.7 1.7 1.7 1.8 1.6 1.6 -0.2 -0.1 1.9
Gout (self-reported) 0.1 0.1 0.6 -0.8 0.2 0.1 0.1 0.1 -0.2 0.2 0.2 0.2 0.5 0.8 -0.1
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 5.6 -0.5 2.4 1.5 1.1 1.1 1.9 2.4 1.0 1.1 0.4 -2.0 1.1
Medication: Amlodipine 0.8 1.1 4.6 0.3 -0.7 -0.9 -1.1 -0.9 0.5 -1.5 -0.9 -0.9 -0.8 -2.2 -0.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 0.3 -0.8 -0.8 -0.8 -0.6 -0.6 -0.4 -0.6 -0.6 0.1 -0.9 -0.7
Birth weight 0.4 0.9 2.4 1.3 -0.9 -1.0 -0.8 -0.8 -1.5 -0.2 -0.8 -0.8 1.1 -0.0 -0.8
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.7 -0.8 0.3 0.4 0.4 0.2 0.6 -0.1 0.3 0.3 -0.7 0.2 0.1
High blood pressure (siblings) 3.5 5.0 7.2 0.5 -2.4 -2.6 -2.6 -2.6 -2.1 -2.4 -2.5 -2.5 1.0 -1.8 -2.7
Forced vital capacity (FVC), Best measure 2.1 7.8 15.1 2.9 -3.9 -3.2 -2.9 -2.8 -3.0 -3.1 -2.7 -2.8 0.2 -0.2 -3.0
Body fat percentage 1.1 4.2 11.9 -2.3 -0.1 -1.9 -1.7 -1.9 -1.6 -1.4 -1.9 -1.9 2.8 -3.5 -1.7
Leg fat percentage (right) 1.6 5.6 10.9 -1.9 -0.9 -2.6 -2.3 -2.4 -1.9 -1.9 -2.5 -2.5 3.1 -3.3 -2.3
Arm fat-free mass (right) 0.6 3.0 4.2 1.8 -1.8 -1.9 -1.6 -1.8 -2.0 -1.0 -1.8 -1.7 1.3 -1.6 -2.0
Exposure to tobacco smoke outside home 0.3 0.5 1.3 -0.3 1.2 0.8 0.7 0.6 1.0 0.5 0.6 0.6 -0.2 0.2 0.5
Comparative body size at age 10 0.1 0.2 0.7 0.0 -0.3 -0.6 -0.5 -0.3 -0.3 -0.0 -0.4 -0.4 0.9 0.4 -0.1
Number of full brothers 0.4 0.5 0.9 -0.9 0.7 0.9 0.9 0.7 0.1 0.9 0.9 0.9 0.2 0.5 0.6
Worry too long after embarrassment 0.7 1.3 3.3 0.7 0.8 1.1 1.1 1.1 0.6 1.5 1.0 1.1 0.9 1.8 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.5 2.1 0.5 0.3 0.4 0.5 0.6 0.7 1.4 0.6 0.7 -0.4 -0.4 0.7
Wheeze or whistling in the chest in last year 2.5 4.5 6.9 -0.9 -2.0 -2.6 -2.3 -2.3 -2.6 -1.9 -2.2 -2.2 1.9 -1.8 -2.4
Number of children fathered 0.7 0.7 3.7 -0.0 -0.0 -0.8 -0.9 -0.8 -0.7 -0.3 -0.8 -0.9 0.6 -1.9 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.3 1.5 -0.7 -0.4 -0.3 -0.4 -1.5 -0.7 -0.4 -0.3 0.0 -0.6 -0.6
Age at first live birth 0.4 0.8 1.6 -1.3 0.3 0.8 1.0 1.0 -0.0 0.8 1.0 1.0 -0.7 0.8 1.0
Pulse wave peak to peak time 1.5 1.7 2.5 -1.6 1.2 1.2 1.4 1.5 1.1 0.8 1.6 1.5 -0.3 1.4 1.5
Health satisfaction 0.5 0.6 1.7 1.3 0.3 0.7 0.7 0.6 0.9 1.1 0.7 0.7 -0.8 0.0 0.7
Shortness of breath walking on level ground 0.2 0.2 1.2 -0.8 0.2 -0.2 0.0 -0.0 -0.2 0.1 -0.0 -0.0 1.1 -1.0 -0.1
Qualifications: College or University degree 0.1 0.4 1.6 1.0 -0.8 0.2 0.2 0.3 -0.9 -0.1 0.4 0.4 -0.6 1.2 0.1
Eye problems/disorders: None of the above 3.3 3.8 5.3 0.1 -1.6 -2.2 -2.3 -2.2 -1.8 -1.7 -2.3 -2.3 1.8 -2.0 -2.1
Mouth/teeth dental problems: Loose teeth 0.8 1.0 2.0 -1.4 0.1 -0.8 -0.9 -0.8 -1.3 -1.1 -0.9 -0.9 1.1 -1.3 -0.8
Emphysema/chronic bronchitis 2.3 2.6 4.4 0.2 -1.1 -2.0 -1.9 -1.7 -1.5 -1.2 -1.6 -1.7 1.8 -2.1 -1.8
Medication for pain relief, constipation, heartburn 2.7 4.6 14.0 1.9 1.0 2.1 2.0 2.0 2.1 1.5 2.0 1.9 -2.5 3.7 1.9
Neck or shoulder pain in last month 0.3 0.5 2.5 -1.1 0.2 -0.5 -0.5 -0.4 0.0 0.0 -0.4 -0.5 1.0 -1.6 -0.2
Medication: Blood pressure 0.4 0.7 2.3 -1.5 1.1 0.7 0.7 0.6 0.9 0.6 0.7 0.6 0.4 -0.9 0.5
Angina (self-reported) 0.2 0.3 0.7 -0.7 -0.5 -0.6 -0.3 -0.3 -0.3 -0.3 -0.2 -0.3 0.8 -0.8 -0.3
Migraine (self-reported) 0.1 0.2 0.7 0.9 -0.1 -0.4 -0.3 -0.3 -0.5 -0.5 -0.2 -0.3 -0.1 0.0 -0.4
Medication: Ibuprofen 1.8 2.2 4.4 -1.3 -0.6 -1.1 -1.4 -1.4 -1.8 -1.9 -1.4 -1.4 1.3 -2.1 -1.6
Medication: Allopurinol 0.1 0.2 0.7 -0.6 -0.1 0.2 0.4 0.3 0.2 0.3 0.3 0.3 0.0 0.9 0.3
Medication: Omeprazole 0.6 0.7 3.5 -1.7 0.6 0.1 0.3 0.4 -0.7 0.8 0.5 0.4 1.9 0.3 0.5
Medication: Seretide 50 evohaler 0.8 0.9 1.9 -0.1 0.8 1.0 1.0 1.0 1.1 0.8 1.1 1.1 -1.4 0.2 0.9
Mean time to correctly identify matches 0.9 1.7 2.7 -0.6 1.5 1.5 1.3 1.4 1.6 1.1 1.3 1.4 -0.4 1.6 1.3
Heart disease (mother) 0.7 0.8 4.7 2.2 -1.0 -0.0 0.1 -0.0 0.2 -0.4 -0.2 -0.2 -1.2 1.4 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 3.5 0.3 0.3 0.9 1.0 0.7 -0.3 0.6 0.8 0.8 -0.6 1.9 0.7
Whole body fat mass 1.0 4.0 10.3 -1.0 -0.7 -2.0 -1.9 -2.1 -1.8 -1.5 -2.1 -2.1 2.5 -3.2 -2.0
Leg fat mass (right) 0.9 3.6 7.2 -0.9 -0.7 -2.0 -1.8 -2.0 -1.7 -1.4 -2.0 -1.9 2.6 -2.7 -2.0
Arm predicted mass (right) 0.6 3.0 4.6 2.1 -1.8 -1.9 -1.6 -1.8 -1.9 -1.0 -1.8 -1.8 1.4 -1.4 -2.0
Pulse rate, automated reading 1.0 3.1 12.2 -3.0 0.8 -1.4 -1.1 -1.0 -1.4 -0.5 -1.1 -1.1 3.5 -2.5 -0.9
Alcohol intake frequency. 0.6 1.3 4.3 -2.1 1.6 0.8 0.9 0.9 0.3 1.0 0.9 0.9 1.1 -1.3 0.8
Comparative height size at age 10 0.1 0.5 1.2 0.7 -1.0 -0.5 -0.6 -0.7 -1.1 -0.4 -0.5 -0.5 -0.5 0.3 -0.9
Number of full sisters 1.1 1.3 3.5 -1.8 -0.2 -1.2 -1.1 -0.9 -0.8 -0.4 -0.9 -0.8 1.6 -1.9 -0.8
Suffer from ‘nerves’ 0.7 1.0 2.1 -0.8 1.4 1.0 1.0 1.1 0.3 1.4 1.0 1.0 0.8 -0.3 1.3
Overall health rating 0.1 0.3 1.3 0.1 0.2 0.3 0.4 0.4 0.5 1.1 0.4 0.4 0.6 -0.4 0.5
Chest pain or discomfort 0.3 0.4 2.0 -0.0 -0.9 -0.8 -0.1 0.0 -0.9 0.7 0.1 0.1 1.4 0.0 0.0
Had major operations 0.4 0.5 3.1 0.3 0.3 -0.0 -0.5 -0.6 -0.4 -0.5 -0.5 -0.5 0.2 -1.8 -0.7
Age at last live birth 0.4 0.5 2.6 -1.6 0.4 0.6 0.7 0.7 -0.3 0.7 0.7 0.7 -0.3 -0.1 0.8
Family relationship satisfaction 0.5 0.7 1.2 -0.7 0.9 0.8 0.8 0.9 0.3 1.1 0.9 1.0 0.6 -0.7 0.9
Leg pain on walking 0.7 0.9 1.7 1.3 -1.2 -0.8 -0.9 -1.0 -1.1 -0.7 -0.8 -0.8 0.1 -0.9 -1.1
Qualifications: NVQ or HND or HNC or equivalent 3.4 4.1 6.0 -0.5 -1.6 -2.2 -2.3 -2.4 -2.3 -2.0 -2.4 -2.4 1.8 -0.7 -2.4
Commuting to job workplace: Car/motor vehicle 1.4 1.6 3.3 -0.8 -1.8 -1.6 -1.3 -1.2 -1.2 -1.7 -1.2 -1.2 -0.1 -0.9 -1.2
Illness, injury, bereavement, stress in last 2 years 4.0 4.9 6.7 0.1 1.2 2.4 2.6 2.5 2.3 2.0 2.5 2.5 -2.4 2.1 2.5
Medication: Aspirin 0.5 0.7 6.1 -0.3 -0.5 -0.6 -0.5 -0.5 -0.1 0.0 -0.4 -0.4 0.5 -2.5 -0.5
Supplements: Vitamin C 0.8 0.9 1.8 1.4 -0.8 -0.9 -1.2 -1.1 -0.8 -0.9 -1.0 -1.1 0.4 -0.2 -1.2
Knee pain experienced in last month 0.6 0.9 1.4 0.4 -1.0 -1.0 -1.0 -1.2 -0.3 -1.2 -1.2 -1.1 -0.0 -0.7 -1.1
Hypertension (Self-reported) 0.3 0.8 4.3 -0.7 0.2 -0.8 -0.7 -0.7 0.3 -0.2 -0.7 -0.7 1.1 -2.1 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 2.5 -1.6 0.5 0.4 0.5 0.6 0.5 0.9 0.5 0.5 0.8 -0.6 0.7
Illnesses of father: Heart disease 0.1 0.1 0.6 -0.7 -0.4 -0.4 0.0 0.1 0.2 0.4 0.1 0.1 0.7 0.3 0.1
Illnesses of siblings: Diabetes 0.3 0.4 2.5 -1.6 0.4 0.1 0.3 0.4 -0.3 0.5 0.6 0.5 0.4 0.7 0.4
Smoking status: Previous 0.2 0.3 1.4 0.4 -0.4 -0.5 -0.5 -0.3 -0.8 0.2 -0.3 -0.2 1.2 -0.7 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.6 11.1 1.8 -2.9 -2.6 -2.1 -1.9 -3.3 -1.6 -1.9 -2.0 1.4 -0.6 -2.0
Whole body fat-free mass 0.5 2.6 7.0 2.6 -1.8 -1.6 -1.4 -1.6 -1.8 -0.9 -1.5 -1.5 0.9 -1.2 -1.8
Leg fat-free mass (right) 0.2 1.3 6.2 2.5 -1.1 -1.0 -0.9 -0.9 -1.1 -0.3 -0.9 -0.9 0.4 -1.0 -1.1
Arm fat percentage (left) 0.8 3.2 10.4 -1.9 0.5 -1.4 -1.4 -1.5 -1.1 -1.0 -1.6 -1.6 3.0 -3.2 -1.4
Average weekly red wine intake 1.8 2.7 6.2 1.4 -2.5 -1.7 -1.7 -1.8 -1.9 -1.0 -1.8 -1.8 0.3 -1.2 -1.7
Handedness (chirality/laterality): Left-handed 0.9 1.0 4.1 1.6 -2.0 -0.8 -0.5 -0.4 -0.2 -0.9 -0.3 -0.4 -1.6 0.7 -0.7
Mood swings 0.6 1.1 3.7 -1.5 1.9 0.6 0.5 0.6 0.6 1.3 0.6 0.6 1.7 0.6 0.8
Loneliness, isolation 1.3 1.8 6.0 -0.0 -1.0 -1.5 -1.3 -1.2 -1.8 -0.6 -1.3 -1.3 2.4 -1.0 -1.1
Long-standing illness, disability or infirmity 0.5 0.7 3.2 -1.5 0.8 -0.2 -0.4 -0.3 -0.2 0.3 -0.3 -0.3 1.8 -1.2 -0.2
Ever had bowel cancer screening 1.5 1.8 5.3 0.6 -1.5 -1.4 -1.5 -1.3 0.1 -1.2 -1.3 -1.2 -1.2 -2.3 -1.2
Diabetes diagnosed by doctor 1.4 2.2 8.6 -2.9 0.1 -1.2 -0.9 -0.9 -1.4 -0.7 -0.9 -0.9 2.9 -1.3 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.6 0.1 -0.7 -1.2 -1.3 -1.3 -1.1 -0.2 -1.3 -1.2 0.9 -1.6 -1.3
Friendships satisfaction 0.9 1.1 1.8 0.0 1.1 1.3 1.1 1.2 1.3 0.9 1.2 1.2 -0.2 0.2 1.3
Qualifications: nursing, teaching 1.9 3.0 4.3 -0.5 1.1 2.0 1.9 2.1 1.7 1.7 2.1 2.1 -1.7 0.9 2.0
Commuting to job workplace: Walk 0.3 0.3 1.9 1.4 -0.0 0.5 0.3 0.2 0.4 0.6 0.2 0.2 -0.0 1.1 0.2
Eye problems/disorders: Cataract 0.4 0.5 0.9 0.2 0.5 0.8 0.8 0.7 0.5 1.0 0.8 0.8 -0.5 0.9 0.7
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.8 -0.2 -0.0 0.1 0.2 0.1 0.8 0.0 0.0 0.1 -0.6 -0.9 0.3
Medication for cholesterol 0.3 0.4 2.6 1.6 -0.7 0.1 0.0 0.0 -0.4 -0.3 0.1 0.1 -0.1 1.4 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.4 -0.0 0.0 -0.3 -0.5 -0.4 0.1 0.2 -0.2 -0.2 0.2 -0.3 -0.6
Back pain experienced in last month 0.4 0.6 0.9 0.8 -0.8 -0.7 -0.9 -0.9 0.2 -0.8 -1.0 -1.0 -0.1 -0.7 -0.8
Mineral and other dietary supplements 2.0 2.7 5.9 0.6 1.7 1.6 1.6 1.7 2.4 2.1 1.7 1.6 -1.4 -0.0 1.8
Breast cancer (self-reported) 0.3 0.4 3.1 0.7 -0.2 -0.2 -0.1 -0.1 -0.2 0.7 0.0 0.0 -0.1 -1.8 -0.2
Asthma (self-reported) 0.6 1.1 1.7 -0.5 -0.9 -1.0 -1.2 -1.2 -1.3 -1.1 -1.1 -1.1 0.7 -0.8 -1.3
Osteoporosis (self-reported) 0.8 1.0 4.3 1.3 -0.4 0.8 1.0 1.0 0.1 0.9 0.9 0.9 -0.5 2.1 1.0
Osteoarthritis (self-reported) 1.1 1.5 2.9 -0.0 -0.9 -1.5 -1.5 -1.4 -0.7 -1.7 -1.5 -1.5 0.8 -0.4 -1.3
Medication: Aspirin 0.7 0.9 7.5 -0.6 -0.4 -0.7 -0.6 -0.6 -0.4 -0.2 -0.6 -0.6 0.8 -2.7 -0.7
Medication: Gliclazide 0.6 0.7 3.3 -1.1 -0.3 -0.7 -0.5 -0.4 -0.7 -0.5 -0.3 -0.4 1.8 -0.9 -0.6
Illnesses of father: None of the above (group 1) 0.2 0.3 2.9 1.7 0.0 0.4 -0.1 -0.1 0.1 -0.1 -0.2 -0.2 -0.5 0.3 -0.0
Smoking status: Current 0.1 0.2 0.7 -0.8 0.8 0.2 0.1 0.1 -0.2 0.6 0.1 0.1 0.8 -0.5 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 10.2 1.8 -3.2 -2.3 -1.7 -1.8 -1.5 -1.8 -1.8 -1.8 -0.1 0.5 -1.7
Whole body water mass 0.5 2.6 7.5 2.7 -1.8 -1.6 -1.4 -1.6 -1.8 -0.8 -1.5 -1.5 0.9 -1.1 -1.8
Leg predicted mass (right) 0.2 1.2 6.1 2.5 -1.0 -1.0 -0.9 -0.9 -1.0 -0.3 -0.9 -0.9 0.5 -1.0 -1.1
Arm fat mass (left) 1.0 4.1 11.1 -0.9 -0.3 -1.9 -1.8 -2.0 -1.7 -1.3 -2.1 -2.0 3.0 -3.3 -2.0
Number of self-reported non-cancer illnesses 0.8 1.4 3.8 0.0 -0.2 -1.3 -1.5 -1.3 -0.7 -0.3 -1.2 -1.3 1.5 -1.9 -1.2
Average weekly champagne plus white wine intake 0.5 0.7 4.5 1.4 -0.8 0.3 -0.0 -0.1 1.0 -0.7 -0.1 -0.1 -2.1 -0.7 0.1
Miserableness 0.8 1.4 2.3 0.8 -0.8 -1.2 -1.5 -1.5 -0.8 -0.8 -1.4 -1.5 1.0 -1.1 -1.5
Guilty feelings 1.1 1.7 4.3 -0.9 1.2 1.0 1.3 1.3 0.6 2.1 1.2 1.2 1.3 1.7 1.3
Wears glasses or contact lenses 0.7 0.8 2.3 1.0 0.2 1.1 0.9 0.8 -0.0 0.8 0.8 0.8 -1.5 0.9 0.8
Ever taken oral contraceptive pill 1.3 1.4 2.4 -0.9 -0.9 -1.3 -1.0 -1.2 -1.4 -0.9 -1.2 -1.2 1.5 -1.6 -1.2
Hearing aid user 2.0 2.3 3.3 -0.8 1.8 1.8 1.6 1.6 1.8 1.6 1.6 1.6 -1.0 -0.4 1.8
Mother’s age at death 0.1 0.1 0.5 0.7 -0.6 -0.4 -0.2 -0.3 0.2 -0.5 -0.2 -0.2 -0.2 -0.0 -0.1
Financial situation satisfaction 1.2 1.4 9.1 3.0 -0.8 -0.4 -1.0 -1.0 -0.3 -1.1 -0.9 -0.9 -0.9 -0.5 -1.1
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.0 1.0 -0.3 0.0 -0.1 -0.0 0.4 -0.4 -0.1 -0.1 -0.8 0.7 0.2
Commuting to job workplace: Public transport 0.3 0.3 1.6 0.6 0.7 0.7 0.1 0.2 1.3 0.0 0.3 0.3 -0.8 -0.3 0.0
Eye problems/disorders: Glaucoma 3.2 3.8 6.1 -1.1 2.5 2.2 2.3 2.3 2.0 1.8 2.2 2.2 -0.9 0.8 2.2
Medication: Blood pressure 0.3 0.5 2.6 -1.4 0.6 -0.5 -0.3 -0.2 0.5 0.0 -0.3 -0.3 0.6 -1.6 -0.0
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.9 1.7 -1.1 -0.9 -1.0 -1.2 -0.4 -1.3 -1.2 -1.2 -0.2 0.4 -1.2
Supplements: Fish oil (including cod liver oil) 1.2 1.6 3.5 -1.0 -0.6 -1.1 -1.2 -1.2 -1.9 -1.5 -1.1 -1.1 1.8 -0.4 -1.3
High cholesterol (Self-reported) 0.9 1.6 4.4 -2.1 2.0 0.9 0.9 1.0 0.3 1.4 1.0 1.0 1.2 -1.6 0.9
Medication: Bendroflumethiazide 0.2 0.3 1.0 0.8 -0.1 -0.5 -0.5 -0.6 -0.1 -0.5 -0.7 -0.7 1.0 -0.1 -0.6
Medication: Paracetamol 2.6 4.0 7.1 -0.4 -1.2 -2.2 -2.0 -1.9 -2.6 -1.7 -2.0 -2.0 2.3 -2.7 -1.8
Medication: Lisinopril 0.4 0.5 1.8 -0.5 0.2 -0.5 -0.7 -0.8 0.3 -0.4 -0.8 -0.8 0.3 -1.3 -0.7
Medication: Atorvastatin 2.9 3.6 6.9 1.0 -2.6 -2.2 -2.0 -2.1 -2.2 -1.4 -2.0 -2.1 1.6 -0.4 -2.0
Illnesses of father: High blood pressure 1.9 2.3 7.8 -1.0 -1.2 -1.9 -1.2 -1.1 -1.9 -1.0 -1.1 -1.2 2.8 -1.7 -1.2
Alcohol drinker status: Never 1.4 1.7 2.9 -1.0 1.3 1.2 1.4 1.6 1.2 1.2 1.7 1.7 -0.5 0.3 1.5
Ever smoked 1.3 2.3 7.7 -0.9 -0.6 -1.4 -1.4 -1.2 -1.9 -0.5 -1.1 -1.1 2.3 -2.8 -1.3
Basal metabolic rate 0.6 3.2 4.8 2.2 -1.8 -1.9 -1.7 -1.9 -2.0 -1.1 -1.8 -1.8 1.2 -1.6 -2.1
Leg fat percentage (left) 1.5 5.4 11.0 -1.6 -1.0 -2.6 -2.3 -2.4 -1.9 -1.9 -2.5 -2.4 2.8 -3.3 -2.3
Arm fat-free mass (left) 0.9 4.4 6.0 1.9 -2.2 -2.3 -2.0 -2.2 -2.4 -1.4 -2.2 -2.2 1.5 -1.9 -2.4
Number of operations (self-reported) 0.3 0.4 1.5 0.7 0.8 0.6 0.2 0.4 1.2 0.4 0.4 0.5 -0.7 -1.0 0.3
Average weekly beer plus cider intake 0.4 0.6 2.0 0.8 -1.4 -0.9 -0.7 -0.7 -0.6 -0.9 -0.7 -0.7 -0.4 0.4 -0.7
Irritability 0.7 1.1 2.6 0.3 0.8 1.1 1.2 1.2 1.0 1.6 1.2 1.1 0.2 0.6 1.4
Risk taking 1.1 1.7 6.3 -0.9 -0.6 -1.4 -1.1 -0.9 -1.4 -0.5 -0.9 -0.9 2.5 -1.9 -1.0
Ever had prostate specific antigen (PSA) test 1.1 1.2 2.0 0.0 -1.0 -1.2 -1.3 -1.3 -0.7 -1.3 -1.4 -1.4 0.1 -1.2 -1.2
Fractured/broken bones in last 5 years 1.1 1.4 3.7 -1.3 1.2 1.0 1.2 1.3 0.2 1.9 1.3 1.4 0.5 0.3 1.2
Age started oral contraceptive pill 2.4 3.0 4.4 -0.5 -2.0 -2.1 -1.7 -1.8 -1.8 -1.8 -1.8 -1.7 1.2 -2.0 -1.9
Diastolic blood pressure, automated reading 1.2 3.7 6.6 -2.3 -0.9 -2.2 -1.9 -1.8 -1.3 -1.9 -2.0 -2.0 2.6 -2.1 -1.6
Ever depressed for a whole week 0.6 0.8 5.6 0.4 0.2 -0.5 -0.9 -0.6 0.4 0.1 -0.6 -0.6 0.9 -2.4 -0.6
Unable to work because of sickness or disability 1.6 2.1 5.9 -0.5 1.8 1.3 1.4 1.4 2.4 1.9 1.4 1.4 -0.5 0.2 1.6
Commuting to job workplace: Cycle 0.1 0.1 0.3 -0.5 -0.0 0.2 0.3 0.0 -0.2 0.2 0.1 0.1 0.2 -0.5 0.0
Myopia 0.1 0.1 0.3 -0.4 0.1 0.5 0.4 0.3 -0.1 0.6 0.2 0.2 0.0 -0.1 0.5
Vascular/heart problems diagnosed by doctor 0.2 0.7 4.6 1.0 -0.6 0.4 0.4 0.4 -0.9 0.0 0.4 0.4 -0.7 2.1 0.3
Cholesterol lowering medication 0.6 0.9 3.2 -1.8 1.4 0.4 0.4 0.4 0.7 1.1 0.4 0.4 1.2 -1.2 0.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 4.2 -1.0 -0.2 -0.7 -0.5 -0.3 -1.1 0.4 -0.2 -0.2 2.0 -0.3 -0.2
Pain experienced in last month 0.2 0.3 0.9 -0.8 0.4 0.1 0.1 0.1 -0.9 0.1 0.1 0.1 0.9 0.8 0.0
Supplements: Calcium 0.4 0.4 1.0 0.6 -0.5 -0.4 -0.6 -0.6 -1.0 -0.3 -0.5 -0.5 0.9 -0.6 -0.8
Basal cell carcinoma (self-reported) 1.2 1.4 2.6 -0.8 1.6 1.3 1.2 1.3 1.2 1.5 1.1 1.1 -0.1 0.6 1.5
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.9 -0.0 -0.5 -0.2 0.1 0.2 -0.3 0.6 0.2 0.3 1.0 0.2 0.3
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.6 0.8 0.4 1.0 1.0 1.0 0.8 0.6 1.1 1.0 -1.1 1.6 0.9
Heart disease (siblings) 0.4 0.5 1.5 0.9 0.8 0.6 0.4 0.4 1.2 0.9 0.4 0.4 -0.2 -0.8 0.5
Alcohol drinker status: Previous 0.8 0.9 2.7 -0.8 1.0 1.0 0.9 0.9 -0.0 0.8 0.8 0.9 1.1 1.7 0.8
Pack years of smoking 1.9 2.8 4.8 -0.7 2.2 1.9 1.8 1.7 2.1 2.1 1.7 1.6 -0.3 0.5 1.9
Impedance of whole body 0.1 0.5 5.1 -2.3 0.4 0.1 -0.0 0.1 -0.9 -0.1 0.1 0.0 0.1 -0.2 0.2
Leg fat mass (left) 1.1 4.1 8.8 -0.8 -0.9 -2.2 -2.0 -2.1 -1.9 -1.6 -2.1 -2.1 2.6 -3.0 -2.1
Arm predicted mass (left) 0.9 4.5 5.9 2.2 -2.3 -2.3 -2.1 -2.2 -2.4 -1.4 -2.2 -2.2 1.5 -1.9 -2.4