Hub : Genes

ZNF837

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0550 0.0260 4.0e-03 0.001 0.018 0.011 0.021 0.009 2.6e-01 2.3e-03 1.4e-02 0.0012 2.7e-02
2 GTEx Adipose Subcutaneous 0.2040 0.0510 1.3e-06 0.103 NA 0.128 NA 0.124 9.1e-09 NA 1.2e-10 NA 2.4e-10
3 GTEx Artery Tibial 0.1866 0.0579 2.2e-04 0.035 NA 0.048 NA 0.017 9.1e-04 NA 1.2e-04 NA 1.7e-02
4 GTEx Brain Hypothalamus 0.2730 0.1020 7.5e-03 -0.011 NA 0.010 NA -0.012 7.2e-01 NA 1.8e-01 NA 8.4e-01
5 GTEx Breast Mammary Tissue 0.1880 0.0620 2.9e-04 0.080 NA 0.114 NA 0.046 6.6e-05 NA 1.9e-06 NA 2.1e-03
6 GTEx Breast Mammary Tissue (Male) 0.2267 0.1137 4.1e-02 0.166 NA 0.028 NA 0.068 1.1e-04 NA 7.6e-02 NA 1.2e-02
7 GTEx Breast Mammary Tissue (Female) 0.0898 0.0654 1.0e-01 0.021 NA 0.000 NA 0.010 7.7e-02 NA 3.1e-01 NA 1.6e-01
8 GTEx Colon Sigmoid 0.1160 0.0530 9.0e-03 0.065 NA 0.062 NA 0.090 2.5e-03 NA 3.2e-03 NA 4.3e-04
9 GTEx Esophagus Muscularis 0.0990 0.0410 2.5e-03 0.056 NA 0.039 NA 0.041 2.5e-04 NA 2.0e-03 NA 1.5e-03
10 GTEx Nerve Tibial 0.2593 0.0627 3.1e-08 0.120 NA 0.230 NA 0.108 8.5e-09 NA 2.7e-16 NA 4.6e-08
11 GTEx Ovary 0.4040 0.0900 4.4e-05 0.190 NA 0.342 NA -0.011 2.1e-05 NA 3.0e-09 NA 7.9e-01
12 GTEx Skin Sun Exposed Lower leg 0.0860 0.0330 7.8e-04 0.046 NA 0.008 NA 0.003 9.9e-05 NA 6.9e-02 NA 1.8e-01
13 GTEx Uterus 0.4090 0.1180 3.0e-03 0.193 NA 0.256 NA 0.260 9.3e-05 NA 5.5e-06 NA 4.5e-06
14 TCGA Brain Lower Grade Glioma 0.0536 0.0322 2.6e-03 0.040 0.010 0.033 NA 0.033 2.1e-05 2.0e-02 1.1e-04 NA 1.1e-04
15 TCGA Lung Squamous Cell Carcinoma 0.0396 0.0230 9.6e-04 0.012 0.016 0.012 NA 0.012 1.6e-02 5.3e-03 1.4e-02 NA 1.3e-02
16 TCGA Ovarian Serous Cystadenocarcinoma 0.1660 0.0710 5.6e-04 0.007 0.036 0.014 NA 0.008 1.0e-01 1.7e-03 3.6e-02 NA 9.1e-02
17 TCGA Stomach Adenocarcinoma 0.0860 0.0470 6.5e-05 0.041 0.060 0.031 NA 0.048 5.9e-04 3.9e-05 2.4e-03 NA 2.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.9 1.4 11.3 -0.2 -0.0 -1.3 0.0 -1.2 -0.0 -0.8 0.9 0.8 0.5 0.7 0.2 0.7 -1.6 -1.6 -3.4 -0.1
Bipolar Disorder or Schizophrenia 2.8 6.8 18.3 -1.7 -2.4 -3.4 0.0 -3.6 -2.0 -3.8 -1.3 0.2 -1.9 -1.5 -2.4 -0.6 -3.3 -3.7 -4.3 -2.7
Depressed Affect (Nagel 2018) 1.3 2.8 11.0 -0.2 -1.2 -1.8 0.0 -0.3 -0.6 -0.2 -2.1 -2.7 -0.4 -2.2 -0.3 -1.6 3.3 1.7 2.8 1.2
Depression (Nagel 2018) 0.7 1.1 4.5 -0.9 -1.2 -1.2 0.0 -1.0 -1.2 -0.7 -0.9 -0.9 -1.1 -2.1 -0.6 -1.9 0.7 -0.2 0.2 -0.2
Intelligence (Savage-Jansen 2018) 0.4 1.1 8.8 0.9 -0.5 -1.2 0.0 -1.1 -1.0 0.0 0.6 0.1 -1.0 -0.4 0.2 -1.6 0.2 -0.5 -3.0 1.0
Neuroticism (Nagel 2018) 1.0 2.3 11.8 0.8 -0.4 -2.0 0.0 -0.4 -0.5 -0.2 -1.3 -2.1 -0.3 -1.3 0.1 -1.9 3.4 1.7 2.0 1.9
Schizophrenia (2018) 3.9 8.0 18.3 -2.0 -3.1 -3.4 0.0 -3.8 -2.5 -4.3 -2.4 -0.4 -2.8 -2.6 -3.3 -1.4 -2.9 -3.5 -2.8 -3.5
Schizophrenia vs Biploar Disorder 0.8 1.1 3.5 -0.9 -0.9 -0.4 0.0 -1.2 -0.8 -1.9 -0.9 0.6 -1.2 -1.6 -1.2 -0.2 -1.4 -0.9 -0.1 -1.4
Worry (Nagel 2018) 0.9 1.9 12.5 1.2 0.6 -0.8 0.0 -0.2 -0.7 0.9 -0.1 -1.6 0.0 0.7 0.9 -1.5 3.5 1.8 1.3 2.1
Alzheimer’s Disease (in mother) 0.4 0.4 2.2 -0.6 0.7 1.5 0.0 0.5 0.6 0.7 -0.4 -0.5 0.9 0.5 0.2 0.9 -0.0 0.9 0.1 0.6
Alzheimer’s Disease (in father) 1.0 1.1 3.2 -0.1 -1.5 -1.0 0.0 -0.9 -0.6 -1.8 -1.3 -0.2 -1.6 -1.5 -1.3 -0.1 0.8 -0.8 1.0 -0.4
Alzheimer’s Disease (including proxy) 0.2 0.3 1.0 -0.5 -0.0 0.5 0.0 0.2 0.5 -0.3 -1.0 -0.7 0.1 -0.2 -0.3 1.0 0.4 0.3 0.7 0.3
Crohns Disease (2017) 0.9 1.9 8.6 0.6 -0.6 -0.8 0.0 -0.8 0.1 -1.6 -1.2 0.7 -1.0 -0.4 -2.9 1.5 -2.2 -2.2 -1.1 -2.0
Irritable Bowel Disease (IBD) 0.9 2.2 7.4 0.3 -0.1 -1.0 0.0 -0.9 0.3 -2.3 -1.4 0.6 -1.0 -0.5 -2.7 1.7 -2.4 -2.2 -0.9 -2.0
Ulcerative Colitis (UC) 0.7 1.3 4.0 0.1 0.1 -0.4 0.0 -1.0 0.0 -2.0 -1.5 0.4 -0.9 -0.6 -1.8 1.0 -1.8 -1.7 -0.5 -1.5
Major Depression (MDD) 0.5 0.7 2.5 -0.4 0.1 -1.2 0.0 0.1 0.6 -0.7 -1.0 0.8 -0.2 1.1 -0.8 0.9 0.0 -1.3 -1.6 -0.2
Reaction Time 0.5 1.0 7.2 -0.6 0.2 -1.1 0.0 0.3 0.6 -0.6 -1.9 0.2 -0.5 -0.4 -1.4 0.1 0.9 0.0 2.7 -0.5
Verbal and Numeric Reasoning (VNR) 0.5 1.2 4.5 1.1 -0.1 -0.3 0.0 0.1 -0.3 1.5 1.7 -0.8 0.3 0.5 1.5 -0.4 0.6 1.0 -2.1 2.0
Breast Cancer 0.6 1.5 7.2 -1.1 -0.3 -0.0 0.0 -0.9 -0.8 0.1 -0.0 2.1 -0.3 1.1 0.1 -1.8 -1.0 -2.2 -2.7 -1.1
Ovarian Cancer 1.1 1.4 6.1 0.5 -1.4 0.2 0.0 -1.4 -2.4 -0.0 -0.1 -0.0 -2.2 -1.3 -0.8 -2.5 0.3 -0.5 -0.5 -0.1
Prostate Cancer 0.4 0.5 4.0 0.1 -0.7 -0.5 0.0 -0.8 -1.0 0.2 0.5 2.0 0.1 -0.3 0.1 -1.1 -0.5 0.0 -0.6 -0.2
Age at First Birth 1.1 1.5 4.6 -1.3 -1.2 -1.1 0.0 -1.4 -1.3 -1.6 -1.8 0.5 -1.7 -0.5 -2.1 -0.7 -0.2 -1.1 0.8 -1.5
Bipolar Disorder (2011) 0.4 0.4 1.5 0.9 -0.3 0.6 0.0 -0.3 0.7 -0.7 -0.3 0.5 0.6 -0.1 -0.5 0.7 -0.6 -0.8 -1.2 -0.1
Body Mass Index (BMI) (2010) 2.5 3.5 10.1 0.8 2.2 1.7 0.0 1.9 1.8 2.0 3.2 0.9 2.5 2.4 2.9 1.1 -1.4 0.8 -1.6 1.5
Coronary Artery Disease (CAD) 1.7 2.0 11.4 -3.4 -1.4 -0.2 0.0 -1.1 -0.9 -0.7 -0.8 -1.7 -0.6 -1.8 -0.4 -0.7 -1.8 -1.7 -0.8 -1.9
Crohns Disease (2012) 0.8 1.3 7.1 1.0 -1.0 -1.2 0.0 -0.6 -0.2 -1.5 -0.8 0.7 -0.9 -1.1 -2.7 1.0 -1.5 -1.2 -0.3 -1.0
Mean Putamen Volume 0.7 0.8 4.3 0.7 0.6 -0.3 0.0 1.1 1.3 0.3 -0.6 -0.7 0.8 0.2 0.3 1.3 0.8 1.0 2.1 0.5
Fasting Glucose 0.5 0.6 1.9 -1.2 -0.4 1.4 0.0 0.2 0.3 0.6 0.8 -0.7 1.3 -0.1 1.0 -1.0 -0.6 -0.2 -0.6 -0.7
HbA1C 0.2 0.2 1.4 0.5 -0.5 0.7 0.0 0.1 -0.5 0.3 -0.2 -1.2 -0.1 0.5 0.2 -0.3 0.4 -0.4 0.4 -0.5
HDL Cholesterol 0.3 0.6 2.0 -0.3 -0.8 -1.1 0.0 -0.8 -0.6 -0.5 -1.4 0.3 -1.3 -1.0 -1.1 -0.4 -0.3 -0.1 0.4 -0.6
LDL Cholesterol 0.2 0.3 2.2 -0.3 0.3 -0.1 0.0 0.3 -0.1 1.1 0.8 0.2 0.7 -0.3 1.5 -0.3 0.5 0.1 -0.6 0.4
Lupus 0.6 0.9 5.1 -0.5 1.0 0.1 0.0 0.4 1.5 -1.1 -0.6 1.2 0.9 -0.1 -0.3 2.2 0.0 -0.3 1.1 -0.6
Neuroticism (2016) 0.8 1.1 4.3 -0.6 -0.0 0.5 0.0 0.5 0.0 1.4 1.1 -0.4 1.0 0.7 2.1 -0.0 1.1 2.0 0.9 1.5
Primary Biliary Cirrhosis 0.6 0.8 2.2 1.0 1.2 0.5 0.0 0.2 0.2 0.8 1.5 0.8 0.8 1.1 1.2 0.2 1.0 1.4 0.1 1.4
Rheumatoid Arthritis 0.6 0.9 3.2 -0.0 0.6 1.8 0.0 -0.2 -0.3 1.0 1.2 1.7 0.9 0.2 1.1 -0.6 -0.7 0.1 -1.7 0.1
Schizophrenia (2014) 3.4 7.4 17.4 -2.0 -2.8 -2.8 0.0 -3.6 -2.0 -4.2 -2.1 0.3 -2.2 -1.7 -2.8 -1.1 -3.3 -3.7 -3.8 -3.4
Triglycerides 0.6 1.0 2.6 0.1 0.5 1.4 0.0 0.9 0.5 1.4 1.6 -1.4 1.6 0.5 1.6 0.5 0.4 0.7 -0.1 0.8
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.5 -0.1 -0.4 -1.1 0.0 0.2 0.4 -1.2 -0.5 0.2 -0.2 -0.8 -0.9 0.5 -1.1 -1.3 -0.2 -1.6
Ulcerative Colitis 1.8 2.6 8.9 -1.1 -1.1 -1.5 0.0 -1.7 -0.8 -2.6 -3.0 0.2 -1.8 -1.5 -2.5 0.9 -1.3 -1.4 0.6 -2.0
Blood Eosinophil Count 0.2 1.6 4.7 1.5 1.7 -0.3 0.0 0.5 0.7 0.4 0.4 1.7 0.8 1.1 1.3 0.4 1.3 2.2 2.0 2.0
Blood Platelet Count 2.0 23.0 98.0 6.6 1.9 1.0 0.0 1.8 -0.8 5.5 6.0 0.4 2.1 2.8 5.9 -2.1 4.8 9.9 3.3 9.5
Blood Red Count 0.4 3.5 8.5 0.5 0.1 1.9 0.0 -0.8 -1.8 2.3 2.9 1.0 0.3 2.4 2.3 -2.8 -0.6 2.1 -2.3 2.6
Blood White Count 0.7 5.4 15.5 3.1 1.4 1.3 0.0 1.4 -0.3 3.6 1.6 1.3 0.8 1.5 2.2 -1.6 3.9 3.8 1.8 3.9
Heel T-Score 0.3 2.2 14.7 1.4 1.5 0.2 0.0 1.8 0.9 1.1 1.0 0.7 0.9 -0.9 1.5 0.9 1.0 2.5 3.8 0.6
BMI 0.5 3.1 14.3 1.7 -1.6 -1.5 0.0 -2.3 -3.0 -1.0 -0.5 -0.9 -3.0 -0.8 -1.4 -3.8 -0.2 -1.0 -1.2 -0.6
Height 0.2 4.6 26.0 5.1 0.7 1.1 0.0 3.0 2.0 1.7 2.6 -1.5 0.5 1.2 1.1 1.0 1.4 2.6 2.4 2.6
Waist Hip Ratio (WHR) 0.5 2.3 5.2 -1.8 -1.6 -0.2 0.0 -1.4 -1.1 -1.5 -2.1 -2.3 -2.1 -1.2 -1.7 -0.5 -0.4 -1.9 0.1 -2.2
Systolic Blood Pressure 0.1 0.4 1.8 1.1 -0.5 1.3 0.0 -0.5 -0.4 -0.6 0.0 -0.7 -0.1 -0.7 -0.8 -0.4 -0.4 -0.6 -0.0 -0.5
Smoking Status 0.4 1.0 5.1 0.8 -0.0 -0.1 0.0 0.8 0.3 1.5 1.2 0.1 1.1 0.3 1.3 0.2 0.7 1.7 -0.3 2.3
Allergy or Eczema 0.1 0.4 1.9 -0.8 0.8 0.9 0.0 -0.5 -0.4 -0.1 -0.4 1.4 -0.5 0.5 0.2 -0.1 -0.2 -0.4 -0.6 -0.6
Cardiovascular Disease 0.2 0.6 1.8 1.2 0.5 -0.8 0.0 0.2 0.2 0.4 0.9 0.5 0.9 0.8 0.8 0.3 0.3 0.1 -1.3 1.3
Hypothyroidism (self reported) 1.3 2.9 10.6 -1.4 -1.8 -1.8 0.0 -1.6 -1.6 -2.0 -1.2 0.3 -1.7 -3.2 -2.6 -1.5 -0.7 -0.7 1.6 -2.1
Respiratory disease 1.7 3.7 9.1 -0.7 -2.5 -2.2 0.0 -2.4 -2.0 -2.6 -2.5 -0.0 -2.8 -2.5 -3.0 -1.3 -0.8 -1.0 0.4 -1.6
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.6 -0.3 0.7 0.9 0.0 1.6 1.5 1.0 0.5 -0.0 1.5 0.4 0.5 0.8 -0.1 0.2 -0.4 0.6
Lung FEV1/FVC ratio 0.1 0.3 1.5 1.0 -0.3 -0.7 0.0 -0.7 -0.8 -0.1 0.0 -0.3 -0.7 0.6 0.5 -1.2 0.6 0.1 0.0 0.4
Lung FVC 0.2 0.9 3.0 0.6 1.5 0.9 0.0 0.8 0.8 0.8 1.6 1.7 0.6 0.4 1.4 0.9 -0.1 0.8 0.5 0.9
Neuroticism 1.3 3.2 15.9 0.2 0.2 -1.5 0.0 0.0 -0.5 0.9 -0.4 -1.8 0.2 -0.5 1.3 -1.2 4.0 3.1 3.2 3.0
Chronotype (morning person) 2.1 4.9 20.8 -2.8 0.2 -0.4 0.0 -1.0 0.4 -3.0 -2.6 0.9 -1.6 -0.1 -3.4 0.8 -2.4 -3.9 -0.5 -4.6
Hair Pigment 0.0 1.2 6.9 1.5 -0.6 0.7 0.0 0.5 -0.3 0.4 0.7 -1.0 0.4 -0.7 0.3 -0.3 1.6 1.9 2.6 1.2
Tanning 0.1 1.2 3.3 -0.8 -0.8 -1.5 0.0 -1.4 -0.8 -1.4 -1.5 -0.7 -1.2 -1.1 -1.8 -0.8 -0.0 -0.6 1.2 -0.8
Hand grip strength (left) 0.3 0.8 3.8 1.5 0.8 0.3 0.0 0.5 0.1 0.4 1.8 1.9 0.4 0.8 0.1 -0.2 -1.3 0.7 0.1 0.5
Number of treatments/medications taken 0.5 0.8 5.1 -0.1 -0.9 -2.2 0.0 -1.2 -1.1 -0.6 -0.1 0.3 -0.6 -0.4 -0.3 -0.9 1.4 0.1 0.1 1.3
Average weekly spirits intake 0.4 0.5 2.0 0.9 -0.2 -0.8 0.0 -0.6 -0.5 -1.4 0.1 0.6 -1.2 -0.7 -1.2 0.4 -1.1 -0.4 0.0 -0.2
Sensitivity / hurt feelings 0.4 0.6 3.7 0.7 -0.4 -0.7 0.0 -0.1 -0.2 0.1 0.1 -1.1 0.5 -0.5 0.4 -1.2 1.9 0.2 0.1 1.4
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.0 -1.1 -1.2 -0.4 0.0 -0.4 -0.6 -0.4 -1.4 -1.4 -0.6 -1.3 -0.8 -1.0 1.2 0.0 1.1 -0.2
Hearing difficulty/problems: Yes 2.0 3.1 9.0 0.3 -1.8 -1.1 0.0 -2.2 -3.0 -1.3 -1.5 -0.4 -2.9 -2.2 -1.3 -2.2 1.0 1.8 2.4 0.3
Relative age of first facial hair 0.9 1.9 10.1 1.6 0.6 -0.2 0.0 0.1 -0.1 1.1 1.9 1.0 0.4 0.9 2.5 -0.7 1.5 1.9 -0.1 3.2
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 12.2 1.1 0.3 0.2 0.0 -0.6 -0.1 -1.4 -1.2 0.8 -1.3 -1.3 -0.7 0.2 1.5 1.6 3.5 0.3
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.1 -0.5 0.6 1.2 0.0 0.3 0.7 0.2 -0.6 -0.7 0.9 1.3 -0.1 1.5 1.3 0.1 0.2 0.4
Ever had hysterectomy (womb removed) 2.0 2.3 9.1 -0.4 0.6 0.3 0.0 1.4 1.5 0.9 -0.1 -3.0 1.4 0.1 1.1 2.1 2.0 2.0 2.0 2.0
Systolic blood pressure, automated reading 0.1 0.4 1.7 0.5 -0.6 1.3 0.0 -0.6 -0.7 0.1 0.7 -0.7 -0.1 -0.4 -0.2 -1.2 -0.7 -0.3 -0.6 -0.5
Eye problems/disorders: Diabetes related eye disease 1.2 1.4 6.2 -1.5 0.7 -0.3 0.0 0.6 0.7 0.1 -2.3 -2.5 -0.3 0.2 -1.0 -0.1 1.8 -1.5 0.6 -1.0
Angina 0.4 0.5 1.7 -1.3 0.5 -0.2 0.0 1.0 1.2 0.5 -0.1 0.0 0.7 0.2 -0.1 1.1 0.5 -0.5 0.9 -0.3
Medication for hormone replacement therapy 0.5 0.6 3.3 -0.6 0.0 0.1 0.0 -0.2 0.4 -0.6 -0.4 -1.0 0.3 0.9 -0.5 0.9 -0.5 -1.4 -1.8 -0.7
Vitamin and mineral supplements 0.6 0.8 3.2 -0.0 0.5 1.1 0.0 0.7 -0.0 0.6 0.7 1.3 -0.1 -1.4 -0.0 -0.1 -1.0 1.5 1.8 0.4
Supplements: Zinc 1.5 1.6 6.6 0.7 -0.9 -0.5 0.0 -0.4 -0.1 -1.1 -0.5 -1.3 -1.0 -0.2 -1.5 1.3 -1.8 -2.6 -1.9 -2.0
Medication: Co-codamol 0.8 0.9 3.0 -0.5 -1.4 -0.6 0.0 -1.7 -1.7 -0.8 0.1 0.8 -1.3 -0.9 -0.7 -0.7 -0.9 -0.4 -1.3 -0.2
Medication: Metformin 0.3 0.4 1.8 -0.3 -0.9 -0.7 0.0 -0.3 -0.3 -0.7 -0.5 -1.3 -0.1 -0.3 -1.0 -0.9 0.0 -0.8 -0.5 -0.2
Diabetes (father) 1.8 2.2 12.8 -1.2 -0.8 0.4 0.0 -1.0 -0.9 -0.8 -0.0 1.0 -1.0 -0.5 -0.8 -0.8 -3.3 -1.9 -3.6 -1.4
Diabetes (mother) 1.2 1.5 8.2 -0.6 -1.0 -0.3 0.0 -1.4 -1.1 -0.6 0.4 0.0 -0.7 -0.4 -0.4 -1.6 -2.1 -1.8 -2.9 -1.4
Severe depression (siblings) 0.9 1.0 4.1 -1.3 1.1 0.5 0.0 0.4 0.8 -0.7 -1.0 -1.3 -0.1 -0.4 -0.9 1.0 -0.4 -2.0 -1.6 -1.3
Pack years adult smoking proportion 0.5 0.8 2.9 -0.2 1.1 1.1 0.0 1.1 0.7 1.6 0.1 -0.4 1.3 1.1 1.7 0.2 0.8 0.8 0.3 0.3
Impedance of leg (right) 0.2 1.0 5.2 -0.6 -0.8 0.7 0.0 0.9 0.8 0.7 -0.8 -2.3 0.8 0.1 0.4 1.0 1.4 0.9 1.5 0.6
Leg fat-free mass (left) 0.3 1.8 8.6 2.9 -0.7 -1.1 0.0 -0.8 -1.2 -1.0 0.5 -0.6 -1.9 -0.2 -1.2 -2.0 -1.0 -1.3 -1.9 -0.6
Trunk fat percentage 1.2 4.8 17.0 1.6 -2.8 -2.7 0.0 -2.9 -3.4 -1.7 -0.9 -2.2 -3.6 -0.7 -1.9 -4.1 1.1 -0.4 -0.2 -0.1
Hand grip strength (right) 0.5 1.4 5.2 2.3 0.6 0.8 0.0 0.9 0.3 0.9 2.1 1.8 0.7 1.2 0.9 -0.2 -0.3 1.7 0.5 1.4
Townsend deprivation index at recruitment 0.1 0.1 0.9 -0.3 -0.1 0.3 0.0 -0.1 -0.0 0.1 -0.2 0.8 0.2 0.9 -0.3 -0.6 -0.0 -0.3 -0.1 -0.2
Current tobacco smoking 1.8 2.9 7.1 0.3 1.7 1.8 0.0 2.6 1.9 2.7 0.5 -0.1 2.4 1.6 1.9 1.4 1.6 2.1 1.3 1.7
Average weekly fortified wine intake 0.4 0.5 1.5 0.6 -0.7 -1.1 0.0 -0.8 -0.7 -0.8 -0.2 0.6 -1.2 -1.0 -0.5 -0.5 -0.3 0.2 0.3 0.6
Maternal smoking around birth 0.3 0.4 1.9 -0.4 -0.1 -1.4 0.0 -0.9 -0.6 -1.4 0.2 -0.4 -0.4 0.1 -0.0 -0.4 0.1 -0.4 -0.3 0.4
Fed-up feelings 1.0 1.8 4.5 -1.7 -1.6 -1.9 0.0 -1.1 -0.9 -0.8 -2.1 -2.0 -0.8 -1.7 -0.5 -1.5 1.6 -0.4 0.7 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 2.1 -1.1 -0.8 -0.4 0.0 -0.2 -0.1 -0.4 -1.2 -1.4 -0.0 -1.4 -0.5 -0.8 0.9 -0.9 0.0 -0.6
Relative age voice broke 2.4 3.6 15.1 2.5 1.5 -0.5 0.0 1.1 1.1 1.6 2.4 0.6 1.4 1.2 2.9 0.8 2.7 2.5 0.5 3.9
Taking other prescription medications 0.6 0.9 2.3 -1.2 -1.0 -1.4 0.0 -1.2 -0.8 -1.0 -1.2 0.2 -0.7 -1.5 -1.3 -0.2 0.5 -0.3 0.9 -0.0
Age when periods started (menarche) 0.9 2.2 9.5 1.3 0.5 -0.6 0.0 0.2 -1.1 2.0 1.8 -0.9 0.2 0.9 2.4 -1.6 1.4 1.6 -1.5 3.1
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 4.0 0.7 -0.0 0.9 0.0 0.7 0.3 0.8 -0.4 -2.0 0.7 0.8 0.4 -0.1 1.7 0.4 0.6 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 22.5 4.7 1.4 0.4 0.0 1.9 0.6 1.9 2.3 0.7 0.3 0.4 1.9 0.9 1.2 1.9 1.2 1.6
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 2.9 0.8 0.7 -0.3 0.0 -0.1 -0.2 0.3 0.9 1.7 -0.1 0.9 1.1 0.0 -0.3 0.8 0.3 1.1
Qualifications: CSEs or equivalent 0.9 1.1 4.5 -0.5 0.0 0.9 0.0 -0.6 -0.8 -0.1 -0.6 1.0 -0.9 -0.1 -1.3 -0.6 -2.0 -1.8 -2.1 -1.2
Serious illness, injury or assault to yourself 2.6 3.1 8.8 -1.0 -1.7 -1.6 0.0 -1.0 -1.0 -1.1 -3.0 -1.7 -2.0 -2.1 -2.7 -2.3 1.7 -0.4 2.4 -1.4
High blood pressure 0.3 0.9 5.7 -0.5 -0.3 -1.5 0.0 -1.3 -0.9 -0.5 0.4 -1.2 -0.3 0.2 0.6 -0.5 -0.5 -1.1 -2.4 -0.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 2.3 -0.3 0.4 0.7 0.0 -0.6 -0.5 -0.3 -0.3 1.5 -0.8 0.4 -0.0 -0.1 -0.4 -0.6 -0.9 -0.6
Multivitamins +/- minerals 0.5 0.6 2.2 0.2 -0.5 -1.4 0.0 -0.6 0.0 -0.2 -1.0 -0.9 0.4 1.2 0.0 -0.2 1.5 -1.1 -1.1 -0.4
Stomach or abdominal pain in last month 0.8 1.0 7.7 -0.6 -1.0 0.1 0.0 -0.8 -1.1 0.2 0.7 -0.7 -0.2 -0.5 0.2 -1.3 -1.2 -1.2 -2.8 0.2
Supplements: Glucosamine 0.4 0.5 1.6 -0.2 -0.7 -0.8 0.0 -0.6 -0.9 -0.0 -1.0 0.1 -0.9 -0.2 -0.5 -1.3 1.2 -0.8 -0.1 0.1
Diverticular disease/diverticulitis (self-reported) 2.6 3.0 11.3 0.1 -1.8 -1.7 0.0 -2.4 -2.7 -1.7 -1.9 -0.5 -3.4 -1.9 -2.2 -1.9 0.1 -1.0 0.6 -1.0
Medication: Atenolol 0.5 0.6 2.2 -0.2 0.4 -0.2 0.0 -0.3 0.6 -0.6 1.2 -0.8 1.0 0.9 0.1 1.3 -0.9 -0.4 -1.5 0.5
Medication: Levothyroxine sodium 1.6 2.6 9.1 -1.4 -2.1 -1.9 0.0 -1.1 -1.6 -1.1 -1.2 -0.4 -1.6 -3.0 -1.8 -2.0 1.0 0.5 2.8 -0.9
Sitting height 0.2 1.2 7.8 2.8 0.6 1.5 0.0 1.4 0.6 1.0 1.3 0.4 0.3 1.5 0.8 0.2 0.7 1.1 0.2 0.5
Chronic bronchitis/emphysema (father) 1.0 1.2 2.7 -0.5 -1.1 -0.2 0.0 -1.4 -1.2 -1.6 -1.4 -0.1 -1.2 -1.1 -1.2 -1.6 -0.7 -1.3 -0.2 -1.2
High blood pressure (mother) 1.1 1.6 5.1 1.0 1.6 1.0 0.0 0.9 1.5 1.3 0.5 1.4 1.4 2.3 0.9 1.6 -0.1 -0.6 -2.0 0.2
Body mass index (BMI) 0.6 2.7 9.1 1.7 -1.4 -1.8 0.0 -2.2 -2.6 -1.2 -0.5 0.1 -2.8 -1.0 -1.7 -3.0 -0.8 -0.9 -1.2 -0.5
Impedance of leg (left) 0.2 1.0 2.9 -1.2 -0.6 0.6 0.0 0.6 0.8 0.5 -0.5 -1.7 1.0 0.3 0.7 1.0 1.5 1.2 1.7 0.9
Leg predicted mass (left) 0.3 1.7 8.2 2.9 -0.7 -1.0 0.0 -0.8 -1.2 -1.0 0.5 -0.7 -1.9 -0.2 -1.3 -2.1 -1.0 -1.3 -1.8 -0.6
Trunk fat mass 1.1 4.7 16.3 2.3 -2.7 -2.7 0.0 -2.6 -3.2 -1.7 -0.8 -2.0 -3.6 -0.8 -2.0 -4.0 0.8 -0.6 -0.4 -0.2
Waist circumference 0.8 2.9 9.3 2.1 -1.6 -2.1 0.0 -1.8 -2.2 -1.4 -1.1 -1.8 -3.0 -0.9 -2.0 -2.8 0.5 -1.2 -0.4 -0.4
Number of incorrect matches in round 0.6 0.9 5.4 0.4 -0.3 -1.4 0.0 -0.9 -0.3 -1.8 -0.5 -0.8 -0.7 -0.5 -1.2 0.8 0.4 0.4 2.3 -0.7
Past tobacco smoking 0.3 0.6 3.8 -0.6 0.3 0.4 0.0 0.1 0.1 -0.2 -0.9 -0.2 -0.5 -0.6 -0.5 -0.2 -0.3 -0.6 1.8 -1.9
Alcohol usually taken with meals 0.2 0.4 1.7 -0.3 -0.0 -0.5 0.0 0.1 0.6 -0.4 -1.3 0.6 0.1 0.1 -0.2 1.1 0.7 -0.3 0.9 -0.7
Nervous feelings 1.1 2.0 12.1 0.7 -0.2 -1.2 0.0 -0.6 -1.0 0.2 -1.4 -1.8 -0.6 -0.4 -0.0 -1.4 3.5 1.5 2.6 1.5
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 5.0 0.1 -0.2 0.2 0.0 0.1 -0.5 0.9 -1.6 -1.9 -0.2 -0.7 -0.4 -2.0 2.2 0.4 0.8 0.7
Hearing difficulty/problems with background noise 2.8 4.5 13.2 -0.3 -2.3 -1.9 0.0 -2.8 -3.4 -1.7 -2.6 -0.4 -3.6 -2.4 -1.6 -3.4 1.1 0.3 1.6 -0.3
Hair/balding pattern: Pattern 2 0.4 0.6 2.5 -0.2 0.1 1.6 0.0 1.4 1.0 0.6 -0.3 -1.0 1.1 -0.4 -0.5 0.5 0.7 -0.5 -0.0 0.2
Had menopause 0.4 0.5 2.8 0.3 -0.4 -0.4 0.0 0.2 -0.5 0.9 -0.1 -0.8 -0.3 -0.7 0.3 -0.5 1.7 0.8 0.9 0.8
Had other major operations 0.9 1.2 3.4 -0.3 -0.8 1.3 0.0 0.3 -1.0 1.8 1.2 0.1 0.0 -1.4 0.8 -1.2 1.7 1.1 -0.0 1.9
Forced vital capacity (FVC) 0.5 1.9 7.2 2.1 1.1 2.1 0.0 1.6 0.7 1.9 2.7 1.4 0.7 0.9 1.4 0.1 -0.4 1.0 -0.6 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 12.7 3.6 1.1 -0.4 0.0 1.4 0.4 1.4 1.1 0.3 -0.0 0.2 1.4 0.9 1.9 1.6 1.8 1.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 3.2 -0.5 -0.4 -1.1 0.0 -0.6 0.7 -1.8 -0.9 -1.5 -0.0 -0.6 -1.1 0.5 -0.5 -0.9 0.7 -1.1
Qualifications: None of the above 0.4 0.9 4.6 -1.1 -0.8 -2.2 0.0 -0.9 -0.6 -1.0 -1.2 -1.2 -0.4 -0.0 -0.8 -0.2 0.2 0.2 1.7 -0.4
Financial difficulties in last 2 years 0.8 1.1 6.7 -0.4 0.4 -0.6 0.0 -1.3 -1.2 0.1 -0.1 2.6 -0.5 0.3 0.1 -1.0 -1.6 -0.3 -1.8 -0.7
Mouth/teeth dental problems 0.4 0.6 1.7 0.4 1.1 1.3 0.0 0.7 0.2 0.9 0.8 0.3 0.2 1.0 0.6 0.2 0.6 1.3 1.1 1.0
Heart attack 0.2 0.2 1.2 -0.7 0.1 -0.8 0.0 -0.0 -0.1 0.4 0.1 1.1 0.1 -0.1 0.1 -0.4 -0.6 0.1 -0.5 0.3
Allergy 0.4 1.0 3.1 1.4 -0.2 -0.9 0.0 1.1 0.8 0.8 0.4 -1.7 0.9 0.2 0.6 -0.1 1.4 1.1 1.7 1.2
Pain all over the body in last month 1.5 1.6 7.2 0.1 2.7 0.7 0.0 1.1 2.1 0.7 1.2 -0.1 2.0 1.3 1.2 1.6 -0.1 0.3 -0.9 1.1
Diabetes (self-reported) 0.5 0.7 2.2 -0.0 1.3 1.4 0.0 1.4 1.5 0.8 0.3 0.1 1.3 1.1 0.1 0.9 -0.1 -0.2 -0.3 0.2
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.4 -1.0 -0.2 -1.2 0.0 -0.9 -0.3 -1.0 -0.2 0.2 -0.7 -0.8 -0.5 -0.0 -1.0 -1.1 -1.2 -0.9
Medication: Ramipril 0.1 0.2 0.6 -0.3 0.1 -0.7 0.0 0.3 -0.1 0.8 0.0 -0.7 0.0 0.2 0.1 0.3 0.5 0.1 -0.3 0.8
Medication: Simvastatin 0.2 0.3 0.8 -0.5 0.7 -0.3 0.0 0.0 0.5 -0.5 -0.4 -0.2 0.9 0.5 0.2 0.7 0.6 0.4 0.8 0.2
Fluid intelligence score 0.4 0.9 5.9 1.3 0.5 -0.2 0.0 0.5 0.2 1.4 1.0 -0.2 0.3 0.6 1.1 -0.1 0.3 0.1 -2.4 1.4
Illnesses of siblings 0.2 0.3 1.6 -0.8 0.8 0.3 0.0 0.4 0.4 -0.4 0.4 0.6 0.0 0.1 -0.4 -0.4 -1.3 -0.6 -0.4 -0.8
Neuroticism score 1.1 2.2 14.3 -0.8 0.6 -1.0 0.0 0.1 0.0 0.5 -0.9 -2.0 0.7 0.1 1.2 -0.9 3.8 1.9 2.5 1.9
Weight 0.5 2.4 9.4 3.1 -1.5 -1.5 0.0 -1.3 -2.0 -0.9 -0.1 -1.1 -2.6 -0.5 -1.5 -2.9 0.1 -0.4 -0.6 0.0
Impedance of arm (right) 0.1 0.5 2.9 -0.8 -0.8 0.2 0.0 -0.4 0.0 -0.5 -0.7 -1.1 -0.0 0.9 -0.1 -0.1 1.7 0.1 0.6 0.3
Arm fat percentage (right) 1.2 4.8 17.3 1.3 -2.4 -2.7 0.0 -3.0 -3.4 -1.9 -1.1 -0.8 -3.8 -1.0 -2.3 -4.2 -0.1 -1.3 -1.0 -0.8
Trunk fat-free mass 0.1 0.6 7.9 2.8 0.2 -0.2 0.0 0.9 0.2 0.2 0.6 -0.6 -0.7 0.1 -0.5 -0.3 -0.3 -0.1 -0.2 0.1
Hip circumference 0.7 2.9 10.3 3.2 -1.4 -2.0 0.0 -1.6 -2.2 -1.1 -0.3 -0.9 -2.9 -0.5 -2.1 -3.0 0.1 -0.6 -0.7 0.1
Time employed in main current job 1.2 1.4 3.9 0.3 -1.2 -1.7 0.0 -1.7 -1.6 -0.7 -1.5 0.2 -1.2 -0.7 -1.7 -2.0 0.3 -0.9 0.4 -0.9
Alcohol intake versus 10 years previously 0.2 0.4 1.5 0.3 0.4 0.4 0.0 0.6 0.8 0.1 0.2 -1.2 0.9 0.2 0.5 0.6 1.0 0.0 0.5 0.3
Father’s age at death 0.5 0.6 2.9 -0.3 0.1 -0.7 0.0 -0.3 -0.9 1.0 0.6 -1.1 -0.2 -1.7 1.1 -1.0 0.8 0.7 0.1 0.4
Worrier / anxious feelings 0.7 1.3 5.4 0.5 0.5 -1.5 0.0 -0.6 -0.2 -1.0 -1.7 -2.2 -0.7 -0.3 -0.5 -0.2 2.3 0.3 2.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 3.1 -0.3 -1.1 -0.1 0.0 -1.0 -1.5 -0.3 -1.2 -1.3 -1.5 -1.6 -0.9 -1.8 1.2 0.4 0.7 0.7
Falls in the last year 1.1 1.5 5.8 -0.5 -0.8 -0.1 0.0 -1.6 -1.2 -1.8 -0.7 2.1 -1.1 -2.4 -0.7 -1.0 -1.4 -0.6 -0.5 -0.8
Hair/balding pattern: Pattern 3 0.4 0.7 3.2 0.4 -0.8 -1.8 0.0 -0.4 -0.7 -0.5 -1.4 -0.5 -1.0 -0.7 -0.7 0.2 1.0 -0.1 0.9 -0.0
Number of live births 0.1 0.2 0.8 -0.1 0.2 -0.5 0.0 0.3 -0.1 0.0 0.1 -0.8 -0.1 -0.3 0.6 0.3 0.5 0.8 0.1 0.9
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 5.6 1.9 0.6 1.3 0.0 0.9 0.0 1.4 2.4 1.6 0.1 1.0 1.2 -0.9 -0.6 0.6 -0.8 1.1
Pulse rate 1.0 1.6 7.2 -1.1 -2.5 -0.1 0.0 -0.1 -1.6 1.0 -0.6 -2.2 -1.4 -0.9 -0.6 -2.7 0.4 0.3 0.4 -0.1
Happiness 0.7 0.8 3.6 -1.4 1.0 1.9 0.0 1.3 1.3 0.8 0.3 0.6 1.3 0.9 0.4 0.3 -0.2 -0.2 0.4 -0.5
Noisy workplace 0.5 0.7 2.2 -1.1 1.5 0.6 0.0 0.6 1.0 0.5 0.5 0.3 1.1 1.0 1.4 1.0 0.5 0.3 0.1 -0.1
Qualifications: A levels/AS levels or equivalent 1.1 2.3 6.1 1.7 0.9 1.5 0.0 1.6 1.6 1.8 2.5 0.2 1.8 2.0 2.0 1.3 0.1 1.2 -1.5 1.6
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 9.5 0.7 -2.1 -1.2 0.0 -1.9 -2.4 -0.8 -0.7 0.6 -1.7 -1.8 -1.6 -3.1 -1.4 -0.6 -0.9 -1.4
Mouth/teeth dental problems: Dentures 0.5 0.8 2.8 -1.6 -1.5 0.8 0.0 -0.4 -0.7 -0.1 -0.5 -0.9 0.2 -0.1 -0.5 -0.6 -0.8 -1.1 -1.7 -1.3
Asthma 0.7 1.3 4.0 -0.2 -0.7 -0.8 0.0 -1.2 -0.7 -1.7 -1.3 1.3 -1.3 -1.2 -2.0 0.7 -1.1 -1.4 -0.6 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 2.0 -1.4 0.5 -0.0 0.0 -0.5 0.1 -0.7 -1.3 0.8 -0.1 -0.3 -0.5 0.2 0.6 -0.4 -0.3 0.1
Medication: Cholesterol lowering 0.3 0.4 1.8 0.0 0.8 -0.6 0.0 0.5 0.6 -0.0 -0.2 0.1 1.1 1.3 0.9 0.5 1.0 0.2 0.5 0.0
Depression (self-reported) 0.7 0.8 3.7 1.9 0.6 1.5 0.0 -0.1 -0.4 0.8 0.7 1.2 0.1 0.1 0.7 -0.2 1.0 0.7 -0.7 1.5
Medication: Lansoprazole 2.2 2.5 6.6 0.9 1.6 1.6 0.0 1.8 1.0 2.5 1.1 0.7 1.6 0.4 1.7 0.4 1.2 2.4 2.0 2.6
Prospective memory result 0.7 0.9 3.5 -1.6 -0.3 -1.1 0.0 -0.6 0.4 -1.9 -1.3 -0.2 -0.3 0.0 -1.0 0.9 -0.1 -1.5 0.3 -1.2
Lung cancer (father) 1.8 2.1 6.8 0.0 1.9 2.6 0.0 1.5 1.3 1.5 2.1 0.9 1.8 2.2 1.7 1.1 -0.9 0.5 -1.1 0.3
Illnesses of mother 1.4 1.7 5.2 0.7 1.2 0.7 0.0 2.2 1.7 1.2 1.1 -0.2 1.1 1.4 1.2 0.7 0.8 1.9 2.3 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 2.9 1.7 0.0 0.6 0.0 0.2 -0.3 0.6 1.3 0.5 -0.4 0.6 0.3 -1.0 -0.4 0.2 -0.6 0.8
Pulse wave Arterial Stiffness index 0.4 0.5 2.6 0.5 0.2 1.3 0.0 1.6 1.0 0.4 -0.0 -0.7 0.2 0.5 -0.8 0.7 -0.3 0.1 0.4 0.1
Impedance of arm (left) 0.2 0.8 4.4 -0.6 -1.3 -0.0 0.0 -0.5 -0.5 -0.2 -0.5 -1.6 -0.1 0.5 0.1 -0.6 2.1 0.9 1.2 0.7
Arm fat mass (right) 1.0 4.0 14.3 1.8 -2.1 -2.4 0.0 -2.5 -3.0 -1.6 -0.7 -0.8 -3.6 -1.0 -2.0 -3.8 -0.5 -1.2 -1.1 -0.8
Trunk predicted mass 0.1 0.6 7.6 2.8 0.3 -0.2 0.0 0.9 0.3 0.2 0.7 -0.5 -0.7 0.1 -0.4 -0.2 -0.3 -0.1 -0.2 0.2
Standing height 0.2 1.5 9.5 3.1 -0.7 0.4 0.0 1.6 0.8 0.7 0.7 -2.5 -0.2 0.9 0.1 -0.4 1.7 0.7 0.7 0.8
Length of working week for main job 3.3 3.6 7.2 -1.1 -2.2 -1.9 0.0 -2.6 -1.8 -2.1 -1.9 0.7 -2.7 -2.0 -2.4 -1.6 -1.3 -2.3 -1.2 -2.2
Exposure to tobacco smoke at home 0.2 0.2 1.7 0.4 0.3 -0.2 0.0 -0.2 0.5 -0.6 0.4 -0.0 0.4 1.3 0.0 0.3 -0.1 -0.3 -0.3 0.1
Breastfed as a baby 0.6 0.7 3.6 0.4 -0.6 -0.6 0.0 -1.2 -1.5 -0.1 -0.3 -0.3 -0.6 -0.7 -0.2 -1.5 1.9 0.2 0.2 -0.1
Tense / ‘highly strung’ 1.2 2.0 7.2 -0.8 1.6 0.8 0.0 1.1 0.7 1.6 0.5 -0.8 1.6 2.4 2.1 0.2 2.7 1.1 0.3 2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 6.6 -1.3 -0.6 -0.9 0.0 -1.0 -0.2 -1.1 -2.6 -2.4 -0.7 -0.3 -1.4 -0.3 0.6 -1.0 -0.2 -0.3
Hair/balding pattern: Pattern 4 2.8 6.9 21.0 0.1 3.4 2.4 0.0 1.8 2.0 2.5 3.7 2.4 3.1 4.6 4.1 1.7 -0.5 3.1 0.1 2.4
Birth weight of first child 0.6 1.1 4.5 2.1 0.2 -0.8 0.0 0.0 -0.1 0.1 1.3 0.2 -0.3 0.7 0.9 -0.3 1.7 1.5 1.8 1.5
Peak expiratory flow (PEF) 0.7 1.6 6.3 1.7 0.4 0.6 0.0 0.7 0.1 0.9 2.5 2.1 0.4 1.2 1.0 -1.0 -1.3 0.2 -2.1 1.1
Pulse wave reflection index 0.7 0.9 2.8 1.0 1.7 1.0 0.0 1.1 1.5 -0.4 0.4 0.9 0.8 0.7 -0.6 1.6 -0.5 -0.8 -0.8 -0.4
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.3 0.2 0.8 -0.7 0.0 -0.4 -0.3 -0.6 -1.3 1.5 -1.0 1.0 -1.3 -0.4 0.4 -0.5 0.4 0.2
Loud music exposure frequency 0.5 0.5 4.6 2.1 -0.5 -0.4 0.0 -0.5 -0.4 0.1 -0.4 0.4 -0.2 0.4 -0.4 -1.2 1.1 0.2 -0.3 0.4
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 6.2 1.1 -1.0 -0.1 0.0 -0.7 -1.5 0.7 0.5 -0.3 -1.0 -0.3 -0.2 -2.1 -0.1 -1.0 -2.5 0.1
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 2.5 -0.0 0.3 -1.6 0.0 -0.4 0.2 -1.3 -0.7 -0.3 -0.5 -0.3 -1.0 -0.1 -0.3 -0.9 -0.1 -0.6
Blood clot in the leg (DVT) 0.6 0.8 3.9 -1.3 -0.3 0.5 0.0 -0.8 -0.8 -0.6 0.2 1.5 -0.5 -1.0 -0.5 -0.8 -2.0 -0.3 -1.0 -0.7
Medication: Paracetamol 0.3 0.4 1.5 0.4 -0.1 1.0 0.0 0.2 0.3 0.3 -0.2 1.2 0.1 0.6 -0.9 -0.1 -0.5 -1.1 -1.0 -0.8
Headache pain in last month 0.3 0.6 2.3 -1.0 -0.5 -0.2 0.0 -0.0 -0.0 0.2 -1.5 0.5 -0.4 -0.8 -1.0 -0.5 0.0 -1.4 -1.5 -0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.5 0.0 0.0 1.2 0.0 0.7 0.5 0.7 -0.3 -0.8 -0.1 -0.2 -0.4 0.1 0.3 0.4 0.9 0.3
Glaucoma (self-reported) 1.0 1.2 4.8 -2.2 -0.6 -1.7 0.0 -0.8 -0.5 -0.8 -2.1 -0.4 -1.1 -1.4 -0.1 -0.5 0.9 -0.8 0.8 -1.2
Gout (self-reported) 1.8 2.4 4.4 -2.1 -1.2 -1.5 0.0 -2.1 -1.9 -1.4 -1.8 0.1 -1.7 -1.3 -1.3 -1.6 -1.4 -1.9 -2.0 -1.1
Hypothyroidism/myxoedema (self-reported) 1.2 2.4 10.8 -1.3 -1.6 -1.8 0.0 -1.3 -1.3 -2.0 -0.8 -0.2 -1.8 -3.3 -2.0 -1.3 -0.1 0.0 2.1 -1.2
Medication: Amlodipine 1.4 2.0 8.0 0.4 -1.3 -2.8 0.0 -1.8 -2.1 -1.5 -1.4 -0.8 -2.0 -0.8 -1.1 -1.8 1.2 -0.5 0.7 0.0
Medication: Ventolin 100micrograms inhaler 2.0 2.6 6.8 -0.4 -1.5 -0.7 0.0 -1.5 -1.4 -1.9 -0.7 1.7 -2.3 -2.6 -2.4 -0.1 -2.6 -1.6 -0.7 -1.7
Birth weight 0.9 2.0 6.9 1.4 -1.7 -2.6 0.0 -1.5 -1.8 -0.7 0.4 -0.1 -2.0 -1.6 -0.4 -1.5 0.9 1.5 1.6 1.3
Chronic bronchitis/emphysema (mother) 1.5 1.7 4.5 -0.9 -1.1 0.1 0.0 -1.1 -1.1 -1.4 -1.9 -1.3 -1.5 -1.4 -2.1 -0.9 -0.8 -1.7 0.0 -2.1
High blood pressure (siblings) 1.0 1.4 4.7 2.2 0.5 0.8 0.0 0.8 1.1 0.6 -0.0 -0.4 1.3 0.9 1.1 1.3 1.9 1.6 1.2 1.9
Forced vital capacity (FVC), Best measure 0.1 0.5 4.9 2.2 0.0 0.8 0.0 0.5 0.0 0.7 1.1 0.2 -0.4 0.4 0.1 -0.3 0.3 0.5 0.0 0.9
Body fat percentage 1.3 5.0 17.1 1.7 -2.8 -2.8 0.0 -3.0 -3.5 -1.9 -1.1 -2.0 -3.6 -1.1 -2.0 -4.1 0.8 -0.5 -0.3 -0.1
Leg fat percentage (right) 0.8 3.0 8.5 1.9 -2.0 -2.0 0.0 -2.3 -2.7 -1.3 -1.3 -1.8 -2.9 -1.0 -1.7 -2.9 0.7 -0.0 0.4 0.2
Arm fat-free mass (right) 0.1 0.7 6.4 2.5 -0.3 -0.9 0.0 0.2 -0.3 -0.3 0.5 -0.8 -1.2 -0.3 -0.7 -1.0 -0.6 -0.4 -0.6 -0.1
Exposure to tobacco smoke outside home 0.3 0.4 2.2 -0.2 0.4 -1.5 0.0 -0.2 0.1 -1.5 0.2 0.0 -0.5 0.3 -0.2 0.5 -0.5 -0.7 -0.1 -0.5
Comparative body size at age 10 0.2 0.7 2.5 1.6 -0.7 -1.2 0.0 -0.7 -0.9 0.5 0.6 0.0 -0.4 0.7 0.2 -0.9 0.8 1.0 -0.7 1.2
Number of full brothers 0.5 0.7 1.8 -0.7 -1.1 -0.4 0.0 -0.7 -0.7 -1.1 -1.1 0.0 -1.4 -1.0 -1.1 0.0 -1.1 -0.3 0.7 -0.9
Worry too long after embarrassment 1.6 2.7 13.8 0.4 1.1 -1.5 0.0 0.7 1.1 0.6 -0.2 -1.4 0.9 0.3 1.4 0.6 3.7 2.3 2.7 2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 5.8 -1.5 -1.1 -0.6 0.0 -1.1 -0.5 -0.8 -2.4 -0.9 -0.7 -0.2 -1.1 -1.4 1.2 -1.5 -0.2 -1.2
Wheeze or whistling in the chest in last year 0.4 0.7 2.6 -1.6 0.7 -0.3 0.0 0.0 0.6 -0.5 -1.6 -0.4 -0.2 0.2 -1.5 0.1 -0.1 -1.5 -0.3 -0.7
Number of children fathered 0.2 0.3 0.8 0.6 -0.7 -0.2 0.0 -0.7 -0.9 -0.1 0.1 -0.4 -0.5 -0.5 0.1 -0.5 0.3 0.9 -0.0 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.7 -0.8 -0.3 -0.7 0.0 -0.5 -0.6 -0.5 -0.7 0.9 -0.7 0.2 -0.3 -0.2 -0.1 -0.1 0.3 -0.2
Age at first live birth 0.3 0.6 1.5 0.0 1.2 1.2 0.0 1.1 1.1 1.1 0.2 0.1 0.8 0.8 0.9 0.7 -0.2 0.2 0.2 0.2
Pulse wave peak to peak time 0.4 0.4 2.3 -0.2 -0.2 -1.4 0.0 -1.5 -0.9 -0.4 -0.1 0.5 -0.3 -0.4 0.7 -0.8 0.4 -0.1 -0.3 -0.2
Health satisfaction 0.5 0.6 1.9 -0.8 0.0 0.4 0.0 0.3 0.7 -0.7 -1.2 -0.8 -0.1 0.4 -1.4 0.6 -0.1 -0.9 1.3 -1.3
Shortness of breath walking on level ground 1.2 1.4 2.9 -1.6 -1.4 -1.1 0.0 -1.3 -1.7 -1.1 -1.6 -1.0 -1.6 -0.7 -1.3 -1.7 0.6 -0.4 0.8 -0.6
Qualifications: College or University degree 0.3 0.9 3.7 1.9 1.0 0.1 0.0 1.4 1.2 1.2 0.5 0.6 0.2 0.9 0.5 -0.0 1.1 0.9 1.1 0.9
Eye problems/disorders: None of the above 1.3 1.6 4.3 1.6 0.9 1.4 0.0 1.0 0.5 1.1 2.1 0.5 1.2 1.7 1.7 0.5 0.3 1.9 -0.1 1.7
Mouth/teeth dental problems: Loose teeth 1.5 1.8 5.3 -1.4 1.5 0.6 0.0 1.3 1.9 0.5 0.8 -0.3 2.0 1.8 0.9 2.3 -0.9 -1.2 -1.9 -0.5
Emphysema/chronic bronchitis 0.4 0.5 1.7 -1.3 -0.5 0.4 0.0 -0.6 -0.6 -0.3 -1.0 -0.7 -0.8 -0.9 -0.8 -0.4 0.0 0.5 1.0 0.1
Medication for pain relief, constipation, heartburn 0.4 0.6 3.1 0.6 -0.1 0.5 0.0 -0.3 -0.2 0.2 1.8 -0.2 0.2 -0.3 1.0 -0.3 -1.4 0.4 -1.7 0.7
Neck or shoulder pain in last month 0.1 0.2 0.5 -0.7 -0.2 -0.0 0.0 0.5 0.3 0.7 -0.3 0.0 0.7 0.2 0.6 -0.1 0.2 0.1 0.2 0.1
Medication: Blood pressure 0.4 0.7 3.2 -0.0 -0.5 -1.2 0.0 -1.0 -0.8 -0.9 0.5 0.5 -0.4 -0.0 -0.4 0.1 -1.4 -1.1 -1.8 -0.7
Angina (self-reported) 0.3 0.4 1.4 -1.2 0.4 -0.0 0.0 0.8 1.0 0.4 -0.2 -0.1 0.4 -0.0 -0.3 1.0 0.5 -0.6 1.1 -0.4
Migraine (self-reported) 0.4 0.5 2.7 -0.6 -0.7 -0.5 0.0 -0.6 -0.8 -0.2 -0.6 -1.0 -0.6 -1.6 -0.3 -0.4 1.0 0.4 0.9 0.6
Medication: Ibuprofen 0.6 0.7 1.7 -1.1 -0.4 -1.2 0.0 -1.1 -0.7 -1.3 -1.3 0.2 -1.2 -0.8 -1.0 -0.6 0.4 -0.3 -0.1 0.0
Medication: Allopurinol 0.9 1.1 5.2 -2.3 -0.6 -1.3 0.0 -1.4 -1.1 -0.6 -0.6 0.1 -0.5 -0.4 0.1 -0.9 -0.9 -1.5 -2.0 -0.3
Medication: Omeprazole 0.3 0.3 1.3 0.1 -0.7 0.6 0.0 0.5 -0.2 1.0 -0.7 -0.0 0.4 0.1 0.5 -0.4 0.5 0.6 1.1 0.3
Medication: Seretide 50 evohaler 0.8 0.9 6.9 -0.4 -0.0 0.2 0.0 -0.8 0.0 -1.2 0.5 1.3 -0.4 -0.3 -0.9 0.1 -2.6 -0.9 -1.3 -0.5
Mean time to correctly identify matches 0.9 1.7 14.8 -0.8 0.2 -2.1 0.0 0.2 0.5 -0.9 -1.5 -0.5 -0.4 -0.5 -0.7 0.6 1.8 1.2 3.9 0.2
Heart disease (mother) 0.4 0.4 2.5 1.6 0.6 -0.0 0.0 0.2 -0.0 0.4 0.1 0.7 -0.2 -0.1 0.6 0.5 1.1 0.6 1.1 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 3.5 -1.3 0.4 1.4 0.0 -0.5 -0.4 0.4 0.8 0.2 1.2 0.1 0.7 -0.7 -0.9 -0.3 -1.9 -0.2
Whole body fat mass 1.0 4.3 14.1 2.3 -2.5 -2.7 0.0 -2.5 -3.0 -1.8 -0.9 -1.8 -3.5 -1.0 -2.1 -3.8 0.3 -0.6 -0.5 -0.3
Leg fat mass (right) 0.9 3.4 10.8 2.1 -1.9 -2.3 0.0 -2.2 -2.6 -1.6 -0.9 -1.5 -3.1 -0.9 -1.9 -3.3 -0.3 -0.8 -0.7 -0.4
Arm predicted mass (right) 0.2 0.8 6.7 2.6 -0.5 -1.0 0.0 0.1 -0.5 -0.3 0.4 -0.8 -1.4 -0.4 -1.0 -1.2 -0.4 -0.5 -0.5 -0.2
Pulse rate, automated reading 0.3 0.9 4.3 -0.5 -1.3 0.1 0.0 0.8 -0.6 1.6 -0.8 -2.0 -0.6 -0.0 -0.4 -2.1 0.9 -0.0 -0.2 0.0
Alcohol intake frequency. 0.6 1.3 6.2 0.1 -1.0 1.0 0.0 -1.3 -1.4 -0.9 0.6 0.2 -0.6 -1.1 -0.7 -0.1 -1.9 -1.4 -2.5 -1.1
Comparative height size at age 10 0.2 1.2 6.3 1.7 -0.3 0.6 0.0 1.9 1.7 0.1 0.0 -2.5 0.4 0.6 -0.8 1.0 0.4 -0.3 1.0 -0.7
Number of full sisters 1.4 1.7 8.8 -0.3 0.1 -1.1 0.0 -0.6 0.6 -3.0 -0.9 -0.5 -0.8 -0.9 -2.2 1.4 -1.8 -1.3 0.9 -1.8
Suffer from ‘nerves’ 1.4 2.1 12.1 0.1 -1.0 -1.8 0.0 -1.4 -1.7 -0.7 -1.4 -1.1 -1.4 -0.7 -0.3 -2.1 3.5 0.8 1.9 0.9
Overall health rating 0.2 0.5 2.9 -0.5 0.0 0.2 0.0 -0.1 -0.2 0.3 -1.0 -1.1 -0.5 -0.5 -0.5 -0.9 1.7 0.1 1.2 0.6
Chest pain or discomfort 0.6 0.8 5.0 -2.2 -0.5 0.1 0.0 -0.8 -0.7 -0.4 -1.2 -1.3 -1.2 -1.2 -0.6 -0.0 0.2 -0.6 -0.4 -0.3
Had major operations 1.9 2.2 9.9 -0.2 -1.7 -3.1 0.0 -1.6 -1.7 -1.3 -1.4 -1.0 -2.3 -1.0 -1.7 -1.4 -0.6 -1.2 -0.3 -1.5
Age at last live birth 0.3 0.5 2.0 -1.1 1.4 -0.0 0.0 0.6 0.7 0.0 -0.2 0.7 0.1 0.4 0.5 1.1 -0.8 -0.5 -0.5 -0.6
Family relationship satisfaction 1.1 1.3 4.0 -2.0 1.8 1.5 0.0 0.7 1.6 0.2 0.2 2.0 1.3 1.9 0.6 0.8 -0.2 -0.3 -0.4 -0.1
Leg pain on walking 0.6 0.7 3.3 0.1 1.1 0.8 0.0 0.8 -0.0 1.0 0.1 0.5 -0.1 0.9 0.2 -0.2 1.1 1.4 1.8 0.9
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 6.0 -0.8 1.1 2.2 0.0 1.0 0.9 1.0 1.2 2.0 1.3 0.7 0.5 0.3 -2.5 -0.8 -1.5 -0.6
Commuting to job workplace: Car/motor vehicle 0.6 0.7 3.2 1.8 0.3 1.1 0.0 0.3 0.3 0.8 0.9 1.5 0.4 0.2 0.1 0.9 0.1 0.6 0.0 1.1
Illness, injury, bereavement, stress in last 2 years 4.5 5.5 11.1 0.8 3.2 2.8 0.0 3.1 3.3 1.8 2.2 -0.5 3.2 3.3 2.4 3.3 0.7 1.5 0.4 2.1
Medication: Aspirin 0.2 0.3 0.9 -0.5 0.4 -0.4 0.0 0.7 0.8 0.0 -0.5 -0.2 0.1 0.5 -0.1 0.9 -0.0 -0.9 0.1 -0.6
Supplements: Vitamin C 1.6 1.8 7.6 -0.9 -1.3 0.4 0.0 -1.2 -0.8 -1.3 -1.0 -0.8 -1.2 -0.3 -1.5 -0.1 -1.5 -2.8 -2.2 -2.2
Knee pain experienced in last month 0.7 1.1 3.5 -1.2 -1.4 -1.2 0.0 -1.0 -1.6 -0.4 -1.3 -0.4 -1.4 -0.0 -1.1 -1.9 0.1 -1.0 -0.3 -0.8
Hypertension (Self-reported) 0.4 1.0 5.8 -0.9 -0.4 -1.6 0.0 -1.3 -0.9 -0.7 -0.0 -1.0 -0.4 0.1 0.1 -0.5 -0.6 -1.5 -2.4 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 4.3 -0.8 0.3 0.4 0.0 0.7 0.6 0.5 0.3 -0.1 0.5 -1.1 0.4 0.1 0.4 0.4 2.1 0.8
Illnesses of father: Heart disease 0.2 0.3 0.7 -0.7 -0.1 -0.6 0.0 -0.8 -0.8 -0.6 -0.2 0.4 -0.6 -0.1 -0.1 -0.6 0.6 -0.8 -0.6 0.0
Illnesses of siblings: Diabetes 0.9 1.1 3.4 0.2 0.7 1.2 0.0 0.5 0.1 1.3 0.9 -0.6 1.0 1.7 1.4 1.0 1.6 1.1 -0.0 1.8
Smoking status: Previous 0.6 0.9 2.9 0.6 -1.4 -1.4 0.0 -1.3 -1.4 -0.7 0.1 0.0 -1.0 -1.0 -0.7 -0.8 -0.1 -0.4 -1.7 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.7 0.8 -0.6 0.8 0.0 0.7 0.5 0.2 0.6 -0.2 0.1 0.6 -0.1 -0.2 -0.8 -0.4 -0.5 -0.1
Whole body fat-free mass 0.1 0.8 8.1 2.8 -0.1 -0.6 0.0 0.1 -0.3 -0.4 0.7 -0.5 -1.2 -0.0 -0.8 -1.0 -0.7 -0.6 -1.0 -0.1
Leg fat-free mass (right) 0.3 1.4 5.9 2.4 -0.5 -0.9 0.0 -0.8 -1.0 -1.0 0.7 -0.2 -1.7 0.0 -1.0 -1.9 -1.0 -1.2 -1.7 -0.6
Arm fat percentage (left) 1.2 4.9 18.6 1.4 -2.5 -2.8 0.0 -3.1 -3.5 -1.8 -1.1 -0.9 -3.7 -1.1 -2.2 -4.3 0.1 -0.9 -0.7 -0.5
Average weekly red wine intake 0.3 0.4 1.9 -0.1 0.8 0.4 0.0 0.8 1.3 -0.6 0.1 -0.6 0.7 -0.0 -0.1 1.4 -0.2 0.1 0.7 -0.4
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.3 1.2 0.7 1.5 0.0 1.4 1.3 0.6 -1.1 -0.3 0.7 0.8 -0.4 0.8 1.1 -0.6 1.1 -0.8
Mood swings 0.8 1.5 7.2 0.4 0.2 -1.2 0.0 0.7 0.6 0.4 -0.5 -1.5 1.1 -0.1 0.6 -0.8 2.7 1.9 1.9 2.1
Loneliness, isolation 0.3 0.4 2.9 0.1 0.4 -0.5 0.0 -0.1 0.3 -0.4 -1.7 -0.8 -0.2 -0.5 -0.5 -0.6 1.5 -0.4 0.4 -0.1
Long-standing illness, disability or infirmity 0.6 0.9 5.7 0.2 0.5 -0.8 0.0 0.1 0.2 0.9 -0.8 0.7 0.3 1.0 0.6 -0.2 2.4 1.2 1.1 1.7
Ever had bowel cancer screening 1.7 2.0 5.1 -1.2 -2.1 -1.4 0.0 -2.0 -2.3 -0.9 -1.9 0.1 -2.0 -0.8 -0.7 -2.0 1.6 -0.3 0.7 -0.2
Diabetes diagnosed by doctor 0.5 0.7 2.2 -0.5 0.9 0.7 0.0 1.3 1.4 0.6 0.6 0.2 1.0 0.6 0.1 0.7 -1.1 -1.1 -1.5 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 3.7 -1.4 0.9 -0.3 0.0 0.3 0.4 -0.2 1.4 0.9 0.3 -0.6 1.0 1.2 -1.8 -0.5 -1.9 -0.1
Friendships satisfaction 1.0 1.2 3.6 -1.9 1.6 1.4 0.0 0.7 1.2 -0.2 -0.4 1.7 0.2 1.0 -0.6 0.2 -1.7 -1.0 -0.3 -1.1
Qualifications: nursing, teaching 1.9 2.9 8.2 2.6 2.9 0.9 0.0 2.4 2.2 1.6 1.2 1.1 0.8 2.5 1.3 2.4 0.6 1.2 0.5 1.3
Commuting to job workplace: Walk 0.7 0.8 3.6 -0.6 -0.6 -0.7 0.0 -0.8 -0.6 -1.2 -1.4 -0.7 -0.6 -0.6 -0.9 -0.8 -0.0 -0.8 0.7 -1.9
Eye problems/disorders: Cataract 0.6 0.7 3.1 -1.0 0.3 0.5 0.0 0.5 1.1 0.3 -1.2 -0.3 0.7 0.2 -0.7 0.6 -0.5 -1.8 -0.9 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 3.3 1.5 -1.6 -1.8 0.0 -0.9 -0.8 -0.5 -0.5 1.2 -1.4 -1.8 -1.1 -1.5 0.3 -0.3 -0.3 0.9
Medication for cholesterol 0.8 1.3 4.6 0.4 -1.4 -0.6 0.0 -0.9 -1.3 -0.8 1.0 1.5 -1.5 -1.4 -0.6 -2.1 -1.6 0.0 -0.2 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 2.3 0.8 0.6 -0.3 0.0 0.1 0.5 -0.5 0.1 -0.5 0.4 1.5 0.0 0.5 1.0 -0.4 -0.8 0.5
Back pain experienced in last month 0.2 0.3 1.3 0.3 -0.5 -0.3 0.0 0.4 -0.2 0.8 0.6 -0.5 -0.1 0.5 0.4 -1.1 1.0 0.4 0.9 0.2
Mineral and other dietary supplements 0.3 0.4 1.0 -1.0 -0.5 0.1 0.0 -0.7 -0.6 -0.7 -0.7 -0.4 -0.7 -0.8 -0.7 -0.3 -0.9 -0.0 0.2 -0.8
Breast cancer (self-reported) 1.1 1.3 4.2 -1.0 -0.5 -0.1 0.0 -1.1 -0.9 -0.8 -1.0 0.4 -1.4 -1.3 -1.8 -0.8 -0.9 -2.1 -0.5 -2.0
Asthma (self-reported) 0.7 1.3 4.4 -0.5 -0.7 -0.9 0.0 -1.1 -0.6 -1.6 -1.4 1.2 -1.3 -1.1 -2.1 0.6 -1.2 -1.6 -0.8 -1.2
Osteoporosis (self-reported) 0.8 0.9 2.6 0.9 -0.9 -1.5 0.0 -1.2 -1.3 0.6 0.7 0.1 -0.8 -0.5 0.4 -1.5 0.5 -0.2 -1.6 1.3
Osteoarthritis (self-reported) 4.3 5.6 12.3 -0.9 -2.8 -2.3 0.0 -2.6 -2.3 -2.7 -3.4 -0.8 -3.1 -3.5 -3.3 -1.8 1.4 -0.4 3.2 -1.6
Medication: Aspirin 0.1 0.1 0.5 0.1 0.1 -0.1 0.0 0.7 0.5 0.5 -0.2 -0.0 0.2 0.3 0.1 0.4 -0.2 -0.4 0.1 -0.4
Medication: Gliclazide 2.3 2.6 6.6 1.0 2.2 1.1 0.0 2.6 2.4 2.0 1.2 0.5 2.5 2.1 0.8 1.6 0.8 1.1 0.9 1.3
Illnesses of father: None of the above (group 1) 1.6 1.9 4.7 1.8 1.2 0.6 0.0 1.8 1.5 1.4 1.5 -0.3 1.9 1.1 1.4 1.9 -0.0 2.2 0.7 1.5
Smoking status: Current 1.6 2.6 5.8 0.3 1.8 1.6 0.0 2.4 1.8 2.3 0.6 0.1 2.3 1.8 1.8 1.3 1.2 1.9 1.0 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.1 0.7 1.0 0.9 0.0 0.5 0.4 0.9 1.4 1.1 0.8 1.2 1.3 0.6 -0.3 0.7 -0.6 0.8
Whole body water mass 0.2 0.9 8.1 2.8 -0.1 -0.6 0.0 0.1 -0.3 -0.5 0.6 -0.5 -1.3 -0.1 -0.9 -1.0 -0.8 -0.7 -0.8 -0.3
Leg predicted mass (right) 0.3 1.3 5.9 2.4 -0.5 -1.0 0.0 -0.7 -1.0 -1.0 0.7 -0.3 -1.6 0.0 -0.9 -1.8 -1.1 -1.2 -1.8 -0.6
Arm fat mass (left) 1.1 4.5 15.4 1.7 -2.3 -2.6 0.0 -2.7 -3.1 -1.8 -1.1 -1.1 -3.8 -1.3 -2.3 -3.9 -0.1 -1.1 -0.7 -0.8
Number of self-reported non-cancer illnesses 1.3 2.3 8.7 -0.1 -1.0 -2.9 0.0 -2.1 -1.5 -2.3 -0.8 1.3 -2.2 -2.1 -1.7 -0.7 -0.3 -0.3 1.2 0.0
Average weekly champagne plus white wine intake 0.7 0.9 5.6 -0.8 -0.0 -0.2 0.0 -0.2 0.1 -1.2 -1.1 -2.4 -0.5 -0.9 -1.2 -0.2 0.2 -1.1 0.3 -1.7
Miserableness 1.2 2.1 10.4 -1.4 -1.7 -1.0 0.0 -0.6 -0.7 -0.6 -2.5 -3.2 -0.7 -1.0 -1.0 -1.1 2.3 0.3 1.8 -0.1
Guilty feelings 1.2 1.8 6.8 -2.2 -0.6 -2.6 0.0 -1.6 -0.8 -1.6 -1.8 -1.0 -1.3 -1.5 -0.6 -1.3 1.0 0.0 1.0 0.0
Wears glasses or contact lenses 0.6 0.7 4.8 1.5 0.1 -1.2 0.0 -0.2 0.4 -0.6 -0.5 0.2 -0.0 0.0 -0.1 0.7 2.2 -0.0 0.8 0.7
Ever taken oral contraceptive pill 1.4 1.6 5.7 -0.3 1.5 1.3 0.0 0.6 1.1 0.0 1.0 1.6 1.2 1.4 0.1 1.4 -2.0 -1.5 -2.4 -0.5
Hearing aid user 0.5 0.6 2.4 0.4 -0.0 0.2 0.0 0.7 0.4 0.4 0.1 0.3 0.7 -0.3 0.4 1.5 0.3 1.6 1.1 1.3
Mother’s age at death 0.8 1.0 3.1 -1.3 -0.5 -1.4 0.0 -0.9 -0.1 -1.6 -1.1 -0.9 -0.5 -1.4 -0.6 0.9 0.6 -1.0 0.8 -1.8
Financial situation satisfaction 0.9 1.1 4.0 -1.2 1.3 0.3 0.0 1.3 2.0 0.5 0.3 0.2 1.7 1.5 0.8 1.1 -0.6 -0.9 -0.9 -0.7
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.5 -0.2 -1.0 0.2 0.0 -0.2 -0.4 -0.8 -1.2 -1.0 -0.3 -1.6 -0.8 -0.2 0.7 0.3 1.5 -1.2
Commuting to job workplace: Public transport 0.4 0.5 1.5 0.3 0.5 -0.1 0.0 1.2 0.9 1.1 -0.1 -1.1 0.5 0.6 0.4 0.4 1.2 0.6 0.7 0.4
Eye problems/disorders: Glaucoma 3.3 3.9 11.0 -3.3 -1.5 -2.9 0.0 -1.9 -1.3 -2.1 -3.1 -0.6 -2.1 -2.5 -1.9 -1.0 -0.6 -2.1 0.1 -2.4
Medication: Blood pressure 0.3 0.6 2.8 -1.0 0.6 0.1 0.0 0.3 0.4 0.6 -0.9 -1.7 0.5 1.0 0.5 0.5 1.5 -0.0 0.5 0.5
Pain type(s) experienced in last month: Hip pain 1.1 1.4 4.9 1.0 -1.1 -1.5 0.0 -1.0 -1.4 -1.0 -0.9 1.0 -1.9 -1.4 -1.6 -2.2 0.4 -0.4 0.9 -0.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.6 0.9 0.5 0.0 0.0 0.6 0.2 0.6 0.8 -0.1 0.6 0.2 0.9 0.3 1.0 0.9 0.2 1.3
High cholesterol (Self-reported) 0.3 0.5 1.9 -0.4 0.4 -1.4 0.0 0.3 0.6 -0.4 0.2 0.5 0.8 0.2 0.7 1.0 0.8 0.5 1.2 0.8
Medication: Bendroflumethiazide 0.2 0.2 0.9 0.6 -1.0 -0.7 0.0 0.2 -0.2 0.3 0.5 -0.3 0.0 0.5 0.2 0.2 -0.5 -0.3 -0.9 -0.7
Medication: Paracetamol 0.3 0.4 2.1 0.6 -0.6 0.8 0.0 0.1 -0.0 0.0 -0.8 0.4 -0.4 0.5 -1.4 -0.6 0.0 -1.1 -0.4 -1.0
Medication: Lisinopril 0.2 0.3 0.9 0.3 0.1 0.8 0.0 -0.3 -0.5 0.8 0.6 0.5 -0.0 0.7 0.8 -0.9 -0.0 0.4 -0.6 0.5
Medication: Atorvastatin 0.4 0.5 1.4 -0.6 -1.2 -1.2 0.0 -0.4 -0.7 -0.1 -1.0 -0.3 -0.9 -0.6 -0.5 -0.7 0.3 -0.4 0.8 -0.2
Illnesses of father: High blood pressure 0.1 0.2 0.6 0.2 -0.1 -0.8 0.0 0.5 0.5 -0.1 -0.6 0.8 0.1 -0.6 0.0 -0.4 0.1 0.0 0.4 -0.3
Alcohol drinker status: Never 1.4 1.6 5.7 -0.1 -0.4 -0.2 0.0 -1.4 -1.2 -1.2 -0.4 -0.0 -1.3 -0.2 -1.7 -1.2 -1.9 -2.4 -2.3 -1.3
Ever smoked 1.2 2.1 8.9 0.6 0.7 0.6 0.0 1.1 1.0 1.6 1.9 0.4 1.7 1.6 2.0 1.2 0.7 1.4 -2.0 3.0
Basal metabolic rate 0.2 1.1 8.8 3.0 -0.5 -0.8 0.0 -0.2 -0.7 -0.5 0.5 -0.7 -1.6 -0.1 -1.0 -1.5 -0.7 -0.7 -0.9 -0.2
Leg fat percentage (left) 0.8 2.7 8.3 1.4 -1.9 -1.9 0.0 -2.5 -2.8 -1.3 -1.0 -1.3 -2.8 -0.9 -1.4 -2.9 0.7 0.1 0.3 0.4
Arm fat-free mass (left) 0.2 0.8 5.3 2.3 -0.3 -0.9 0.0 -0.2 -0.6 -0.5 0.1 -0.6 -1.7 -0.5 -1.1 -1.1 -0.7 -0.7 -0.5 -0.3
Number of operations (self-reported) 1.1 1.6 5.0 0.0 -1.3 -1.4 0.0 -1.3 -1.8 -0.5 -1.4 -0.2 -2.0 -2.2 -1.3 -2.1 1.2 -0.4 0.4 0.1
Average weekly beer plus cider intake 0.3 0.4 1.8 -0.1 1.3 0.8 0.0 0.3 0.6 0.1 -0.2 1.3 0.6 1.2 -0.1 0.5 -0.1 -0.2 0.1 0.7
Irritability 0.5 0.8 3.9 -0.9 0.5 -0.2 0.0 0.6 0.6 0.6 -0.7 -2.0 1.2 0.0 0.7 -0.4 1.6 0.6 0.7 1.5
Risk taking 0.7 1.1 7.0 -1.4 0.4 0.3 0.0 0.2 0.8 -0.3 0.4 -0.0 0.8 0.4 0.2 0.3 -2.6 -1.0 -2.3 -0.5
Ever had prostate specific antigen (PSA) test 0.6 0.7 5.9 0.1 0.8 -0.4 0.0 0.2 0.1 -0.8 -0.4 -0.7 -1.0 0.1 -0.5 0.5 1.0 1.1 2.4 0.7
Fractured/broken bones in last 5 years 0.6 0.7 2.9 -0.2 -0.7 -0.3 0.0 -0.5 -0.4 -0.1 -1.1 -0.2 -0.6 -0.7 -0.7 -1.2 -0.9 -1.3 -1.7 -1.6
Age started oral contraceptive pill 1.0 1.2 4.8 -1.6 0.1 1.4 0.0 0.2 -0.2 0.6 0.1 -1.7 0.5 -0.2 1.4 -0.3 2.2 1.7 1.3 1.3
Diastolic blood pressure, automated reading 0.4 1.1 5.1 0.5 -1.2 0.0 0.0 -1.3 -1.5 -0.4 0.4 -0.0 -1.2 -1.0 -0.8 -2.3 -1.6 -0.7 -1.1 -0.8
Ever depressed for a whole week 1.3 1.6 5.0 1.1 1.3 -0.3 0.0 0.7 1.4 0.5 -0.3 -0.8 1.4 1.2 0.4 1.3 2.0 2.0 2.2 1.5
Unable to work because of sickness or disability 0.2 0.2 0.7 -0.5 0.3 0.3 0.0 -0.7 -0.6 0.2 -0.7 -0.4 -0.8 0.2 -0.3 -0.3 0.5 0.1 0.2 0.8
Commuting to job workplace: Cycle 1.0 1.3 5.5 -0.3 -0.3 -1.2 0.0 0.3 -0.1 -0.0 -2.3 -1.7 -0.7 -0.0 -1.4 -0.8 1.7 -1.0 1.8 -1.0
Myopia 0.6 0.9 5.5 1.8 0.8 1.0 0.0 0.3 0.4 0.4 1.3 0.7 0.4 0.6 0.4 0.2 -1.2 -0.6 -2.4 0.4
Vascular/heart problems diagnosed by doctor 0.2 0.6 3.5 0.2 -0.1 1.6 0.0 0.9 0.7 0.2 -0.5 0.4 -0.1 -0.5 -0.7 0.3 0.2 0.7 1.9 -0.3
Cholesterol lowering medication 0.3 0.5 2.3 -0.4 -0.0 -1.5 0.0 -0.2 -0.2 -0.5 -0.8 0.3 -0.2 -1.0 -1.0 0.3 0.1 0.3 1.5 0.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.4 -0.1 -1.2 0.2 0.0 -0.4 -1.1 0.4 -0.8 -0.4 -0.5 -0.7 -0.2 -1.1 0.6 0.3 1.0 0.1
Pain experienced in last month 0.2 0.3 1.5 0.1 0.4 0.3 0.0 0.3 0.3 -0.2 1.2 -0.0 0.5 0.5 0.6 0.6 -0.7 0.5 -0.6 0.4
Supplements: Calcium 1.1 1.2 9.3 0.4 0.3 0.2 0.0 -0.7 -0.5 -0.0 0.9 2.1 -0.3 0.8 -0.2 0.7 -1.1 -1.5 -3.1 -0.2
Basal cell carcinoma (self-reported) 0.4 0.5 4.3 -2.1 -0.3 0.2 0.0 -0.2 0.2 -0.6 -1.0 -0.1 -0.1 -0.7 -0.9 -0.1 -0.0 -0.7 0.7 -0.9
Heart attack/myocardial infarction (self-reported) 0.2 0.2 1.3 -0.5 0.2 -1.1 0.0 0.0 -0.0 0.4 0.2 1.1 0.1 0.0 0.2 -0.3 -0.5 0.1 -0.6 0.3
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 5.8 -1.4 -0.4 0.4 0.0 -1.0 -0.8 -1.0 0.1 1.6 -0.7 -1.3 -0.8 -0.9 -2.4 -0.7 -1.2 -1.1
Heart disease (siblings) 0.3 0.3 1.9 -0.3 -0.6 -1.4 0.0 0.3 0.5 0.1 0.7 0.1 0.3 -0.2 0.7 1.3 -0.2 0.3 0.2 0.0
Alcohol drinker status: Previous 0.2 0.2 0.9 -0.1 0.2 0.9 0.0 -0.3 -0.2 -0.4 0.6 -0.2 0.1 -0.5 -0.0 0.5 -0.9 0.4 -0.8 0.2
Pack years of smoking 0.5 0.7 2.6 -0.1 0.7 1.0 0.0 0.9 0.5 1.6 -0.0 -0.7 1.2 1.1 1.6 0.2 0.7 0.5 -0.2 0.2
Impedance of whole body 0.2 0.9 4.5 -1.0 -1.3 0.1 0.0 -0.2 -0.1 0.1 -0.7 -1.9 0.2 0.3 0.4 0.0 2.1 0.9 1.3 0.8
Leg fat mass (left) 0.8 3.0 10.0 1.8 -1.9 -2.2 0.0 -2.2 -2.5 -1.6 -0.8 -1.4 -3.0 -0.8 -1.7 -3.2 -0.3 -0.7 -0.7 -0.3
Arm predicted mass (left) 0.1 0.7 6.3 2.5 -0.2 -0.5 0.0 0.1 -0.4 -0.4 0.4 -0.6 -1.4 -0.5 -0.9 -0.8 -0.7 -0.5 -0.6 -0.1