Hub : Traits :

Breast Cancer

1233 significantly associated models · 271 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 9395261 11390336 4 2 3.3e-10 2.5e-20 4.6e-04 86 APITD1 PEX14
2 1 17738167 19504300 2 1 4.6e-16 1.2e-12 8.2e-01 100 KLHDC7A
3 1 44623428 47418426 9 1 2.5e-08 3.0e-08 1.5e-02 81 GPBP1L1
4 1 109500439 110936557 3 1 7.4e-08 9.2e-07 4.0e-03 66 GSTM2
5 1 113541801 115152814 2 1 4.7e-11 4.4e-11 1.9e-01 96 DCLRE1B
6 1 117708477 119169364 1 1 5.0e-09 1.7e-10 2.7e-04 68 GDAP2
7 1 120208297 121312687 3 3 2.4e-50 1.8e-52 1.0e+00 100 HIST2H2BA
8 1 144896319 145747463 3 1 4.3e-13 2.3e-10 2.2e-03 77 ANKRD34A
9 1 149672809 150515021 3 1 1.3e-09 1.1e-14 1.3e-06 61 RP11-196G18.24
10 1 154462360 156838141 18 2 5.0e-11 4.8e-11 1.0e+00 100 FAM189B SEMA4A
11 1 203068720 204522489 1 1 1.8e-07 2.1e-10 3.2e-05 57 ZC3H11A
12 2 9397003 10840338 1 1 7.7e-08 3.5e-08 1.5e-01 93 GRHL1
13 2 24324172 25889403 4 1 3.3e-12 1.0e-11 2.7e-01 97 ADCY3
14 2 120301828 121747406 1 1 3.7e-10 5.3e-20 5.1e-18 11 RALB
15 2 171683107 173114238 1 1 1.1e-09 6.2e-12 4.1e-10 17 CYBRD1
16 2 201131124 203176201 5 1 4.4e-17 1.4e-16 1.0e+00 100 ALS2CR12
17 2 216800372 218224510 1 1 4.6e-16 3.2e-93 6.2e-79 16 IGFBP2
18 3 26460080 28211713 2 3 8.7e-63 5.2e-63 1.0e+00 100 NEK10 SLC4A7
19 3 46094540 47958037 2 1 5.2e-15 5.8e-19 5.4e-07 68 PRSS45
20 3 63121945 64684683 3 1 2.1e-12 3.0e-12 1.0e+00 100 ATXN7
21 3 98838914 100872536 5 2 2.6e-09 5.2e-10 2.4e-02 87 CMSS1 NIT2
22 3 140350567 141867638 1 1 1.0e-13 2.9e-14 1.0e+00 100 ZBTB38
23 3 155768424 157226796 1 1 2.0e-07 6.8e-07 3.6e-01 97 LINC00886
24 4 38097478 39643536 3 1 1.1e-10 1.5e-12 1.7e-03 80 FAM114A1
25 4 83635581 85097232 3 1 7.1e-10 6.3e-09 5.9e-01 99 MRPS18C
26 4 88486806 89898476 1 1 2.1e-09 1.6e-09 1.0e+00 100 PPM1K
27 4 174723835 176136330 1 1 3.7e-08 5.2e-26 6.7e-21 21 HPGD
28 5 12225 1546049 3 3 1.2e-07 3.9e-19 1.3e-19 -3 EXOC3 SDHA ZDHHC11
29 5 44048891 45516364 3 4 4.8e-58 4.8e-58 1.0e+00 100 MRPS30 RP11-53O19.1 RP11-53O19.3
30 5 49462228 50836718 1 1 1.5e-07 1.5e-08 3.7e-06 33 PARP8
31 5 55509554 57256096 4 2 7.5e-67 8.8e-98 4.6e-30 70 CTD-2310F14.1 GPBP1
32 5 80580063 82378422 3 1 7.9e-13 8.9e-13 1.0e+00 100 ATG10
33 5 130830617 133140038 6 2 1.3e-08 9.4e-09 1.0e+00 100 HSPA4 UQCRQ
34 6 12934687 14408104 1 1 2.1e-10 6.4e-13 2.4e-05 66 RANBP9
35 6 19840492 21930988 1 1 3.8e-07 4.4e-09 4.2e-06 38 CDKAL1
36 6 80481695 81872212 1 1 5.4e-09 3.1e-09 1.1e-01 93 RP11-250B2.5
37 6 122034905 123452449 1 1 3.9e-08 2.3e-06 5.3e-02 83 HSF2
38 6 129638583 131163098 2 1 6.2e-14 3.0e-12 9.2e-01 100 RP11-73O6.3
39 6 151030107 153655470 2 2 2.7e-07 4.8e-54 3.4e-54 0 RMND1 SYNE1
40 7 90874777 92571165 4 1 5.2e-11 5.1e-11 2.6e-01 97 CYP51A1
41 7 93516077 94977637 1 1 1.5e-12 5.5e-13 6.6e-02 94 SGCE
42 7 101330734 102943552 4 1 1.5e-12 1.2e-11 3.5e-06 53 SPDYE6
43 7 139088401 140791820 3 1 1.1e-16 1.1e-16 1.0e+00 100 JHDM1D
44 7 143425361 144768633 1 1 4.8e-12 1.2e-11 1.0e+00 100 ARHGEF5
45 8 23001988 24411303 1 1 1.6e-09 5.6e-08 2.8e-01 96 STC1
46 8 75200357 76644573 1 1 4.1e-08 3.1e-24 6.9e-23 6 CRISPLD1
47 8 123814825 125250560 1 1 1.3e-08 2.2e-12 4.1e-15 -25 FBXO32
48 8 128107136 129812343 1 1 7.5e-21 8.1e-62 3.0e-45 28 PVT1
49 9 21303958 22705094 1 1 2.0e-13 1.2e-19 2.5e-08 62 CDKN2B
50 9 106163708 107600193 1 1 1.1e-08 1.9e-07 1.0e+00 100 SMC2
51 10 21087485 22724472 2 1 1.0e-12 1.8e-19 2.6e-08 62 MLLT10
52 10 64195778 65606229 1 1 1.9e-08 1.6e-49 5.8e-46 7 NRBF2
53 10 113511441 115622375 2 1 8.4e-14 1.0e-14 1.2e-14 1 TCF7L2
54 10 122801759 124407934 2 1 7.1e-12 0.0e+00 9.6e-302 3 ATE1
55 11 198510 2705175 18 3 9.0e-34 6.3e-33 1.8e-03 93 PIDD RNH1 TNNT3
56 11 64721908 67294308 13 3 1.1e-12 3.9e-12 8.6e-01 100 C11orf80 EFEMP2 RNASEH2C
57 11 68227852 70159781 2 2 8.5e-09 2.8e-43 5.6e-37 15 CCND1 RP11-554A11.9
58 11 110908587 112335631 1 1 1.9e-07 2.5e-07 1.8e-01 93 PPP2R1B
59 14 91001921 93847625 3 3 1.8e-12 8.2e-13 3.5e-07 49 CCDC88C GPR68 RIN3
60 14 104497543 105959867 5 1 7.4e-09 5.9e-08 9.1e-01 100 RP11-982M15.2
61 15 63099535 64579572 1 1 2.2e-07 6.6e-05 1.6e-03 37 USP3
62 15 74431715 76613093 6 2 6.5e-09 2.9e-07 3.5e-01 97 MAN2C1 ULK3
63 15 90776375 92225560 4 1 9.5e-16 1.9e-15 1.0e+00 100 RCCD1
64 16 3304762 4855279 1 1 1.6e-07 2.6e-06 5.0e-02 83 ADCY9
65 16 51773126 53271249 1 1 1.6e-204 6.9e-201 1.0e+00 100 TOX3
66 16 55697964 57248479 3 1 1.2e-09 6.3e-08 6.9e-02 89 BBS2
67 16 79939049 81534790 1 1 1.5e-08 6.2e-27 2.7e-20 26 CDYL2
68 17 28642141 30034689 1 1 4.4e-10 1.4e-09 3.7e-04 66 RP11-848P1.7
69 17 39993748 41393295 2 1 1.2e-08 1.7e-07 1.4e-06 15 NAGLU
70 17 42774693 45796313 16 1 1.2e-11 1.8e-10 1.0e+00 100 LRRC37A4P
71 17 52287259 54097059 5 1 2.1e-27 1.1e-28 1.0e+00 100 STXBP4
72 17 77072043 78469357 1 1 3.5e-10 3.9e-10 1.0e+00 100 CBX8
73 19 12365196 13960562 3 1 5.9e-11 1.1e-08 1.8e-10 -25 IER2
74 19 16699813 20451172 14 3 2.8e-28 2.8e-28 1.0e+00 100 ANKLE1 GATAD2A SSBP4
75 19 43422999 45202640 9 2 3.5e-17 1.4e-16 2.3e-01 98 KCNN4 PINLYP
76 20 48109475 49505582 1 1 1.1e-11 9.9e-10 3.7e-02 88 CEBPB
77 22 27675538 30357801 5 8 2.1e-14 2.8e-11 NaN NaN CHEK2 HSCB RHBDD3 TTC28 XBP1
78 22 37643564 42059768 12 6 1.2e-19 1.1e-34 4.4e-10 74 APOBEC3B BAIAP2L2 C22orf23 MCHR1 MKL1 TNRC6B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.89 9 4 12.1 -0.08 8.3e-01 ADCY3 ADCY9 DCLRE1B FAM189B NAGLU SSBP4 UQCRQ USP3 ZBTB38
Irritable Bowel Disease (IBD) 1.70 5 4 12.1 0.05 9.4e-01 ADCY3 FAM189B NAGLU UQCRQ USP3
Ulcerative Colitis (UC) 1.34 1 0 0.0 0.00 1.0e+00 NAGLU
Verbal and Numeric Reasoning (VNR) 0.94 2 0 0.0 0.00 1.0e+00 C22orf23 LRRC37A4P
Ovarian Cancer 2.52 5 3 9.1 0.29 6.3e-01 ANKLE1 CHEK2 LRRC37A4P MLLT10 RCCD1
Prostate Cancer 1.94 2 1 3.0 0.00 1.0e+00 GRHL1 RP11-554A11.9
Body Mass Index (BMI) (2010) 1.29 1 1 3.0 0.00 1.0e+00 ADCY3
Coronary Artery Disease (CAD) 1.43 1 1 3.0 0.00 1.0e+00 CDKN2B
Crohns Disease (2012) 1.79 3 1 3.0 0.00 1.0e+00 NAGLU UQCRQ USP3
Neuroticism 1.16 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Primary Biliary Cirrhosis 1.16 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Rheumatoid Arthritis 2.33 1 1 3.0 0.00 1.0e+00 DCLRE1B
Schizophrenia 1.14 3 1 3.0 -0.58 4.2e-01 GATAD2A MCHR1 RP11-53O19.3
Triglycerides 1.31 3 1 3.0 0.00 1.0e+00 BAIAP2L2 GATAD2A NRBF2
Type 2 Diabetes (T2D) 1.79 1 1 3.0 0.00 1.0e+00 TCF7L2
Blood Eosinophil Count 1.47 10 7 21.2 0.13 7.3e-01 ADCY3 CYP51A1 EFEMP2 GATAD2A LRRC37A4P NRBF2 RIN3 RNASEH2C RP11-73O6.3 UQCRQ
Blood Platelet Count 2.29 26 20 60.6 -0.01 9.8e-01 ALS2CR12 C22orf23 CBX8 CDKAL1 CDKN2B CHEK2 CYP51A1 EFEMP2 EXOC3 FAM189B GATAD2A GDAP2 GPBP1L1 GSTM2 HSF2 LRRC37A4P MAN2C1 NRBF2 RALB RCCD1 RIN3 RNASEH2C RP11-848P1.7 SLC4A7 SMC2 UQCRQ
Blood Red Count 1.73 20 13 39.4 0.14 5.5e-01 ATXN7 BAIAP2L2 C11orf80 CYP51A1 EXOC3 FAM114A1 FAM189B GPBP1L1 IER2 LRRC37A4P MAN2C1 NRBF2 PPP2R1B PRSS45 RANBP9 RNASEH2C RP11-73O6.3 SSBP4 ULK3 ZBTB38
Blood White Count 1.22 15 11 33.3 0.22 4.4e-01 ALS2CR12 APITD1 CDKN2B DCLRE1B EFEMP2 HSF2 LRRC37A4P MAN2C1 NEK10 NRBF2 PEX14 RIN3 RP11-73O6.3 SSBP4 UQCRQ
Heel T-Score 2.22 28 22 66.7 0.07 7.3e-01 ADCY9 ANKLE1 ATE1 C22orf23 CEBPB CHEK2 CYBRD1 CYP51A1 FAM189B HSCB HSPA4 LINC00886 LRRC37A4P PEX14 PINLYP RHBDD3 RIN3 RMND1 RP11-196G18.24 RP11-554A11.9 RP11-73O6.3 SLC4A7 SSBP4 SYNE1 TTC28 USP3 XBP1 ZBTB38
BMI 1.53 12 9 27.3 0.14 6.6e-01 ADCY3 ADCY9 C22orf23 CBX8 CYBRD1 EFEMP2 GPBP1L1 MKL1 MLLT10 PIDD RP11-73O6.3 TCF7L2
Height 3.01 34 26 78.8 -0.14 4.3e-01 ADCY3 ADCY9 ANKLE1 BAIAP2L2 C11orf80 CRISPLD1 CTD-2310F14.1 CYBRD1 CYP51A1 EXOC3 FAM189B GPBP1L1 GSTM2 LRRC37A4P MAN2C1 NEK10 PINLYP PPP2R1B PRSS45 PVT1 RP11-196G18.24 RP11-250B2.5 RP11-73O6.3 RP11-848P1.7 SDHA SGCE SMC2 SSBP4 STC1 SYNE1 TNNT3 UQCRQ XBP1 ZBTB38
Waist Hip Ratio (WHR) 2.17 16 10 30.3 -0.28 2.8e-01 CDKAL1 CHEK2 CYBRD1 FAM189B HSPA4 LRRC37A4P MAN2C1 PIDD PPP2R1B PVT1 RP11-250B2.5 RP11-554A11.9 RP11-73O6.3 TCF7L2 XBP1 ZBTB38
Systolic Blood Pressure 2.03 16 10 30.3 -0.31 2.5e-01 ADCY3 ADCY9 CRISPLD1 CYP51A1 GPBP1L1 HSPA4 LRRC37A4P NAGLU NEK10 RIN3 RNASEH2C SLC4A7 TCF7L2 TNNT3 TOX3 ULK3
Smoking Status 1.15 3 1 3.0 0.00 1.0e+00 CBX8 GPBP1L1 MLLT10
Allergy or Eczema 3.00 11 3 9.1 0.08 8.1e-01 CHEK2 EFEMP2 FAM114A1 NAGLU RNASEH2C SSBP4 TTC28 ULK3 UQCRQ XBP1 ZBTB38
Cardiovascular Disease 1.41 6 3 9.1 0.10 8.6e-01 ADCY9 HSPA4 NEK10 RNASEH2C TNNT3 ULK3
Hypothyroidism (self reported) 2.19 2 1 3.0 0.00 1.0e+00 DCLRE1B RIN3
Respiratory disease 1.62 3 2 6.1 0.00 1.0e+00 FAM114A1 RIN3 UQCRQ
Type 2 Diabetes (T2D) 2.58 3 3 9.1 0.00 1.0e+00 CDKAL1 MAN2C1 TCF7L2
Lung FEV1/FVC ratio 1.65 13 7 21.2 -0.17 5.8e-01 ADCY3 C22orf23 GPBP1L1 HSPA4 IGFBP2 LRRC37A4P MCHR1 MKL1 MLLT10 NRBF2 TNRC6B UQCRQ ZBTB38
Lung FVC 1.68 13 6 18.2 0.18 5.5e-01 C11orf80 CBX8 FAM189B HSPA4 LRRC37A4P MAN2C1 MLLT10 NRBF2 RIN3 RP11-848P1.7 RP11-982M15.2 SLC4A7 ZBTB38
Neuroticism 1.11 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Chronotype (morning person) 1.06 1 0 0.0 0.00 1.0e+00 ADCY3
Hair Pigment 0.52 16 8 24.2 -0.11 6.7e-01 ADCY3 APITD1 ARHGEF5 CCND1 CDKAL1 CTD-2310F14.1 CYP51A1 LRRC37A4P NRBF2 PPP2R1B RP11-554A11.9 RP11-73O6.3 SSBP4 STC1 TOX3 ZBTB38
Tanning 0.30 4 4 12.1 0.51 4.9e-01 ADCY3 BAIAP2L2 LINC00886 RP11-554A11.9
Hand grip strength (left) 1.76 6 4 12.1 -0.64 1.7e-01 ADCY3 CBX8 IER2 LRRC37A4P RP11-73O6.3 ZBTB38
Number of treatments/medications taken 1.15 2 1 3.0 0.00 1.0e+00 DCLRE1B MLLT10
Sensitivity / hurt feelings 1.61 2 2 6.1 0.00 1.0e+00 GATAD2A LRRC37A4P
Hearing difficulty/problems: Yes 1.32 1 0 0.0 0.00 1.0e+00 GPBP1L1
Relative age of first facial hair 1.61 3 1 3.0 0.00 1.0e+00 HSPA4 LRRC37A4P ZBTB38
Ever had hysterectomy (womb removed) 1.43 1 0 0.0 0.00 1.0e+00 MLLT10
Systolic blood pressure, automated reading 1.51 5 3 9.1 0.65 2.4e-01 GPBP1L1 LRRC37A4P TNNT3 TOX3 ULK3
Eye problems/disorders: Diabetes related eye disease 1.27 1 0 0.0 0.00 1.0e+00 TCF7L2
Angina 1.24 1 0 0.0 0.00 1.0e+00 CDKN2B
Supplements: Zinc 1.33 1 0 0.0 0.00 1.0e+00 NRBF2
Medication: Metformin 2.45 1 1 3.0 0.00 1.0e+00 TCF7L2
Diabetes (father) 2.17 2 2 6.1 0.00 1.0e+00 CDKAL1 TCF7L2
Diabetes (mother) 1.85 2 2 6.1 0.00 1.0e+00 CDKAL1 TCF7L2
Impedance of leg (right) 1.46 12 7 21.2 0.48 1.1e-01 ADCY3 CBX8 CYBRD1 EFEMP2 FAM189B GATAD2A LRRC37A4P MKL1 NAGLU PIDD RIN3 RP11-73O6.3
Leg fat-free mass (left) 2.07 16 9 27.3 0.04 8.7e-01 ADCY9 BAIAP2L2 CBX8 CYBRD1 EFEMP2 FAM189B GATAD2A MLLT10 PIDD RIN3 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SYNE1 UQCRQ ZBTB38
Trunk fat percentage 1.68 9 8 24.2 0.21 5.8e-01 ADCY3 BAIAP2L2 C22orf23 LRRC37A4P MLLT10 RIN3 RP11-196G18.24 SDHA ZBTB38
Hand grip strength (right) 1.74 7 4 12.1 -0.10 8.3e-01 ADCY3 CBX8 LRRC37A4P MAN2C1 MLLT10 RP11-73O6.3 ZBTB38
Maternal smoking around birth 0.82 1 0 0.0 0.00 1.0e+00 MLLT10
Fed-up feelings 1.10 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Relative age voice broke 1.06 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Taking other prescription medications 1.37 3 1 3.0 0.00 1.0e+00 DCLRE1B GATAD2A XBP1
Age when periods started (menarche) 1.20 3 1 3.0 0.00 1.0e+00 ADCY3 C22orf23 LRRC37A4P
Bilateral oophorectomy (both ovaries removed) 1.44 1 0 0.0 0.00 1.0e+00 MLLT10
Heel bone mineral density (BMD) T-score, automated (left) 1.50 4 1 3.0 0.59 4.1e-01 ATE1 RMND1 RP11-73O6.3 SYNE1
High blood pressure 1.57 5 2 6.1 0.03 9.6e-01 HSPA4 MLLT10 NEK10 TNNT3 ULK3
Hayfever, allergic rhinitis or eczema 2.75 7 4 12.1 -0.49 2.6e-01 EFEMP2 FAM114A1 NAGLU RNASEH2C ULK3 UQCRQ ZBTB38
Supplements: Glucosamine 1.03 1 0 0.0 0.00 1.0e+00 ULK3
Medication: Levothyroxine sodium 1.81 1 1 3.0 0.00 1.0e+00 DCLRE1B
Sitting height 2.38 16 13 39.4 0.23 4.0e-01 ADCY3 BAIAP2L2 CRISPLD1 GPBP1L1 LRRC37A4P MAN2C1 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SDHA SSBP4 STC1 STXBP4 SYNE1 UQCRQ ZBTB38
High blood pressure (mother) 1.38 1 0 0.0 0.00 1.0e+00 TNNT3
Body mass index (BMI) 1.48 10 4 12.1 -0.11 7.7e-01 ADCY3 C22orf23 CBX8 CYBRD1 EFEMP2 GPBP1L1 MLLT10 PIDD RP11-73O6.3 TCF7L2
Impedance of leg (left) 1.49 12 7 21.2 0.51 8.8e-02 ADCY3 CBX8 CYBRD1 EFEMP2 FAM189B GATAD2A LRRC37A4P MKL1 NAGLU PIDD RIN3 RP11-73O6.3
Leg predicted mass (left) 2.06 15 9 27.3 0.04 9.0e-01 ADCY9 BAIAP2L2 CYBRD1 EFEMP2 FAM189B GATAD2A MLLT10 PIDD RIN3 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SYNE1 UQCRQ ZBTB38
Trunk fat mass 1.73 10 7 21.2 0.14 7.0e-01 ADCY3 ADCY9 BAIAP2L2 C22orf23 MLLT10 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SDHA ZBTB38
Waist circumference 1.47 7 3 9.1 0.35 4.4e-01 ADCY3 ADCY9 C22orf23 CMSS1 MLLT10 SDHA ZBTB38
Past tobacco smoking 1.43 6 0 0.0 -0.25 6.3e-01 ADCY3 C22orf23 CBX8 DCLRE1B FAM189B MLLT10
Alcohol usually taken with meals 1.36 1 0 0.0 0.00 1.0e+00 XBP1
Nervous feelings 1.41 2 1 3.0 0.00 1.0e+00 CBX8 LRRC37A4P
Frequency of tenseness / restlessness in last 2 weeks 1.06 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Hearing difficulty/problems with background noise 1.17 2 1 3.0 0.00 1.0e+00 LRRC37A4P ULK3
Hair/balding pattern: Pattern 2 1.49 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Forced vital capacity (FVC) 2.17 10 8 24.2 -0.03 9.4e-01 ADCY3 CCND1 LRRC37A4P MAN2C1 MLLT10 RIN3 RP11-196G18.24 RP11-73O6.3 SYNE1 ZBTB38
Heel bone mineral density (BMD) T-score, automated (right) 1.56 5 2 6.1 -0.24 7.0e-01 ATE1 RMND1 SYNE1 XBP1 ZBTB38
Ever unenthusiastic/disinterested for a whole week 1.35 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Qualifications: None of the above 0.91 1 1 3.0 0.00 1.0e+00 NRBF2
Mouth/teeth dental problems 1.00 1 0 0.0 0.00 1.0e+00 FAM189B
Allergy 2.50 4 4 12.1 0.58 4.2e-01 EFEMP2 FAM114A1 UQCRQ ZBTB38
Diabetes (self-reported) 2.26 3 1 3.0 0.00 1.0e+00 DCLRE1B IER2 TCF7L2
Hayfever/allergic rhinitis (self-reported) 1.74 1 1 3.0 0.00 1.0e+00 FAM114A1
Neuroticism score 1.11 2 1 3.0 0.00 1.0e+00 LRRC37A4P TOX3
Weight 1.92 16 10 30.3 0.10 7.1e-01 ADCY3 ADCY9 BAIAP2L2 C22orf23 CBX8 CYBRD1 EFEMP2 FAM189B MLLT10 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SDHA SYNE1 TCF7L2 ZBTB38
Impedance of arm (right) 1.90 17 9 27.3 0.41 1.1e-01 ANKLE1 BAIAP2L2 CBX8 CYBRD1 EFEMP2 FAM189B LRRC37A4P MKL1 MLLT10 NRBF2 PEX14 RIN3 RP11-196G18.24 RP11-73O6.3 TCF7L2 TNNT3 TNRC6B
Arm fat percentage (right) 1.59 6 5 15.2 -0.39 4.4e-01 ADCY3 BAIAP2L2 C22orf23 MLLT10 RP11-196G18.24 TCF7L2
Trunk fat-free mass 2.47 17 10 30.3 -0.02 9.4e-01 ADCY9 ANKLE1 APITD1 CBX8 CYBRD1 CYP51A1 EFEMP2 FAM189B GATAD2A MAN2C1 MKL1 RIN3 RP11-73O6.3 RP11-848P1.7 SYNE1 UQCRQ ZBTB38
Hip circumference 1.83 12 9 27.3 0.07 8.3e-01 ADCY3 BAIAP2L2 CYBRD1 EFEMP2 MLLT10 PIDD RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SDHA TCF7L2 ZBTB38
Worrier / anxious feelings 1.21 2 1 3.0 0.00 1.0e+00 LRRC37A4P TTC28
Frequency of tiredness / lethargy in last 2 weeks 1.05 1 0 0.0 0.00 1.0e+00 SSBP4
Hair/balding pattern: Pattern 3 1.31 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Number of live births 1.20 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Forced expiratory volume in 1-second (FEV1) 1.96 12 6 18.2 -0.04 9.0e-01 ADCY3 CBX8 CCND1 HSPA4 LRRC37A4P MAN2C1 RIN3 RP11-196G18.24 RP11-73O6.3 RP11-982M15.2 SYNE1 ZBTB38
Pulse rate 1.18 1 1 3.0 0.00 1.0e+00 ZBTB38
Qualifications: A levels/AS levels or equivalent 1.16 1 0 0.0 0.00 1.0e+00 NRBF2
Mouth/teeth dental problems: Dentures 1.15 1 1 3.0 0.00 1.0e+00 FAM189B
Asthma 1.81 2 2 6.1 0.00 1.0e+00 FAM114A1 UQCRQ
Medication: Ibuprofen (e.g. Nurofen) 0.94 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Medication: Cholesterol lowering 1.05 2 0 0.0 0.00 1.0e+00 GATAD2A TCF7L2
Forced expiratory volume in 1-second (FEV1), Best measure 1.85 13 6 18.2 -0.06 8.4e-01 ADCY3 CBX8 CCDC88C CCND1 HSPA4 LRRC37A4P MAN2C1 RIN3 RP11-196G18.24 RP11-73O6.3 RP11-982M15.2 SYNE1 ZBTB38
Impedance of arm (left) 1.96 18 10 30.3 0.39 1.1e-01 ANKLE1 BAIAP2L2 CBX8 CYBRD1 EFEMP2 FAM189B LRRC37A4P MKL1 MLLT10 NRBF2 PEX14 PIDD RIN3 RP11-196G18.24 RP11-73O6.3 TCF7L2 TNNT3 TNRC6B
Arm fat mass (right) 1.57 10 7 21.2 -0.23 5.3e-01 ADCY3 BAIAP2L2 C22orf23 CYBRD1 MLLT10 RP11-196G18.24 RP11-73O6.3 SDHA TCF7L2 ZBTB38
Trunk predicted mass 2.47 17 10 30.3 -0.02 9.4e-01 ADCY9 ANKLE1 APITD1 CBX8 CYBRD1 CYP51A1 EFEMP2 FAM189B GATAD2A MAN2C1 MKL1 RIN3 RP11-73O6.3 RP11-848P1.7 SYNE1 UQCRQ ZBTB38
Standing height 2.83 21 18 54.5 0.12 6.2e-01 ADCY3 ADCY9 BAIAP2L2 C11orf80 CRISPLD1 CTD-2310F14.1 CYP51A1 EXOC3 GPBP1L1 LRRC37A4P MAN2C1 PRSS45 PVT1 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SDHA SSBP4 SYNE1 UQCRQ ZBTB38
Hair/balding pattern: Pattern 4 2.17 4 3 9.1 0.32 6.8e-01 CDKAL1 HSPA4 LRRC37A4P ZBTB38
Birth weight of first child 1.29 1 1 3.0 0.00 1.0e+00 ZBTB38
Peak expiratory flow (PEF) 1.57 3 1 3.0 0.00 1.0e+00 LRRC37A4P SMC2 SYNE1
Medication: Paracetamol 1.51 2 1 3.0 0.00 1.0e+00 LRRC37A4P MLLT10
Headache pain in last month 1.33 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Medication for cholesterol, blood pressure or diabetes 1.04 1 0 0.0 0.00 1.0e+00 ULK3
Gout (self-reported) 1.34 1 1 3.0 0.00 1.0e+00 PPM1K
Hypothyroidism/myxoedema (self-reported) 2.08 1 1 3.0 0.00 1.0e+00 DCLRE1B
Medication: Amlodipine 1.40 1 1 3.0 0.00 1.0e+00 TNNT3
Medication: Ventolin 100micrograms inhaler 1.29 1 0 0.0 0.00 1.0e+00 UQCRQ
Birth weight 1.53 3 0 0.0 0.00 1.0e+00 ADCY9 RP11-73O6.3 SYNE1
High blood pressure (siblings) 1.26 1 0 0.0 0.00 1.0e+00 TNNT3
Forced vital capacity (FVC), Best measure 2.04 9 9 27.3 -0.13 7.5e-01 ADCY3 LRRC37A4P MAN2C1 MLLT10 RIN3 RP11-196G18.24 RP11-73O6.3 SYNE1 ZBTB38
Body fat percentage 1.64 10 6 18.2 -0.11 7.5e-01 ADCY3 BAIAP2L2 C22orf23 MLLT10 RIN3 RP11-196G18.24 SDHA SLC4A7 TCF7L2 ZBTB38
Leg fat percentage (right) 1.69 8 6 18.2 -0.08 8.5e-01 ADCY3 BAIAP2L2 C22orf23 GPBP1L1 MAN2C1 MLLT10 RIN3 TCF7L2
Arm fat-free mass (right) 2.25 13 10 30.3 0.17 5.8e-01 ADCY9 CBX8 CYBRD1 EFEMP2 FAM189B MAN2C1 MKL1 MLLT10 RIN3 RP11-73O6.3 RP11-848P1.7 SYNE1 ZBTB38
Comparative body size at age 10 2.72 4 3 9.1 -0.53 4.7e-01 ADCY3 ADCY9 EFEMP2 GATAD2A
Worry too long after embarrassment 1.38 2 0 0.0 0.00 1.0e+00 ATG10 LRRC37A4P
Age at first live birth 1.25 1 0 0.0 0.00 1.0e+00 GATAD2A
Qualifications: College or University degree 1.07 5 2 6.1 -0.44 4.6e-01 GPBP1L1 IER2 LRRC37A4P MLLT10 NRBF2
Medication for pain relief, constipation, heartburn 1.08 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Medication: Blood pressure 1.22 3 1 3.0 0.00 1.0e+00 NEK10 TNNT3 ULK3
Angina (self-reported) 1.28 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication: Ibuprofen 1.01 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Medication: Allopurinol 1.31 2 1 3.0 0.00 1.0e+00 FAM189B PPM1K
Mean time to correctly identify matches 1.23 2 0 0.0 0.00 1.0e+00 C22orf23 RP11-73O6.3
Whole body fat mass 1.67 12 7 21.2 -0.04 9.0e-01 ADCY3 ADCY9 BAIAP2L2 C22orf23 CYBRD1 EFEMP2 MLLT10 RP11-196G18.24 RP11-73O6.3 SDHA TCF7L2 ZBTB38
Leg fat mass (right) 1.68 9 7 21.2 -0.14 7.1e-01 ADCY3 BAIAP2L2 C22orf23 EFEMP2 MLLT10 RP11-73O6.3 SDHA TCF7L2 ZBTB38
Arm predicted mass (right) 2.25 13 11 33.3 0.17 5.9e-01 ADCY9 CBX8 CYBRD1 EFEMP2 FAM189B MAN2C1 MKL1 MLLT10 RIN3 RP11-73O6.3 RP11-848P1.7 SYNE1 ZBTB38
Pulse rate, automated reading 1.30 6 1 3.0 0.56 1.9e-01 ANKLE1 HSPA4 MRPS30 RP11-53O19.3 SLC4A7 ZBTB38
Alcohol intake frequency. 0.97 2 1 3.0 0.00 1.0e+00 LRRC37A4P ULK3
Comparative height size at age 10 2.56 13 11 33.3 0.22 4.6e-01 ADCY3 ADCY9 BAIAP2L2 CRISPLD1 GPBP1L1 LRRC37A4P PRSS45 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SYNE1 UQCRQ ZBTB38
Overall health rating 0.90 1 0 0.0 0.00 1.0e+00 MLLT10
Hypertension (Self-reported) 1.54 6 2 6.1 -0.08 8.8e-01 ADCY9 HSPA4 MLLT10 NEK10 TNNT3 ULK3
Illnesses of father: Heart disease 1.40 1 0 0.0 0.00 1.0e+00 CDKN2B
Illnesses of siblings: Diabetes 1.44 1 1 3.0 0.00 1.0e+00 TCF7L2
Smoking status: Previous 1.36 1 0 0.0 0.00 1.0e+00 CBX8
Forced expiratory volume in 1-second (FEV1), predicted 2.23 5 4 12.1 0.48 4.1e-01 ADCY3 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 ZBTB38
Whole body fat-free mass 2.33 17 11 33.3 -0.05 8.5e-01 ADCY9 ANKLE1 APITD1 CBX8 CYBRD1 EFEMP2 FAM189B GATAD2A MAN2C1 MKL1 PIDD RIN3 RP11-73O6.3 RP11-848P1.7 SYNE1 UQCRQ ZBTB38
Leg fat-free mass (right) 2.07 16 11 33.3 -0.05 8.6e-01 ADCY9 BAIAP2L2 CBX8 CYBRD1 EFEMP2 FAM189B GATAD2A MAN2C1 PIDD RIN3 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SYNE1 UQCRQ ZBTB38
Arm fat percentage (left) 1.59 6 5 15.2 -0.39 4.5e-01 ADCY3 BAIAP2L2 C22orf23 MLLT10 RP11-196G18.24 TCF7L2
Average weekly red wine intake 1.15 2 0 0.0 0.00 1.0e+00 C11orf80 ULK3
Handedness (chirality/laterality): Left-handed 1.17 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Mood swings 1.15 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Loneliness, isolation 0.96 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Long-standing illness, disability or infirmity 1.05 1 1 3.0 0.00 1.0e+00 DCLRE1B
Diabetes diagnosed by doctor 2.47 3 1 3.0 0.00 1.0e+00 DCLRE1B IER2 TCF7L2
Mouth/teeth dental problems: Mouth ulcers 1.62 2 2 6.1 0.00 1.0e+00 CEBPB LRRC37A4P
Medication for cholesterol 1.25 1 1 3.0 0.00 1.0e+00 TNNT3
Breast cancer (self-reported) 7.30 13 7 21.2 0.98 2.2e-10 CTD-2310F14.1 CYBRD1 GPBP1 HIST2H2BA MCHR1 MRPS30 NEK10 PVT1 RP11-53O19.1 RP11-53O19.3 SLC4A7 TNRC6B TOX3
Asthma (self-reported) 1.78 2 2 6.1 0.00 1.0e+00 FAM114A1 UQCRQ
Medication: Gliclazide 1.85 1 1 3.0 0.00 1.0e+00 TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.34 3 2 6.1 0.00 1.0e+00 CBX8 LRRC37A4P RIN3
Whole body water mass 2.33 17 11 33.3 -0.06 8.2e-01 ADCY9 ANKLE1 APITD1 CBX8 CYBRD1 EFEMP2 FAM189B GATAD2A MAN2C1 MKL1 PIDD RIN3 RP11-73O6.3 RP11-848P1.7 SYNE1 UQCRQ ZBTB38
Leg predicted mass (right) 2.07 16 11 33.3 -0.05 8.6e-01 ADCY9 BAIAP2L2 CBX8 CYBRD1 EFEMP2 FAM189B GATAD2A MAN2C1 PIDD RIN3 RP11-196G18.24 RP11-73O6.3 RP11-848P1.7 SYNE1 UQCRQ ZBTB38
Arm fat mass (left) 1.56 11 7 21.2 -0.15 6.7e-01 ADCY3 BAIAP2L2 C22orf23 CYBRD1 EFEMP2 MLLT10 RP11-196G18.24 RP11-73O6.3 SDHA TCF7L2 ZBTB38
Number of self-reported non-cancer illnesses 1.10 1 0 0.0 0.00 1.0e+00 MLLT10
Average weekly champagne plus white wine intake 1.16 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Miserableness 0.86 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Guilty feelings 1.17 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Mother's age at death 1.42 1 0 0.0 0.00 1.0e+00 SLC4A7
Commuting to job workplace: Public transport 1.26 1 0 0.0 0.00 1.0e+00 XBP1
Medication: Blood pressure 1.46 3 3 9.1 0.00 1.0e+00 LRRC37A4P TNNT3 ULK3
Supplements: Fish oil (including cod liver oil) 1.18 1 0 0.0 0.00 1.0e+00 C11orf80
High cholesterol (Self-reported) 0.97 1 1 3.0 0.00 1.0e+00 GATAD2A
Medication: Bendroflumethiazide 1.43 2 1 3.0 0.00 1.0e+00 TNNT3 ULK3
Medication: Paracetamol 1.48 2 1 3.0 0.00 1.0e+00 LRRC37A4P MLLT10
Medication: Atorvastatin 1.11 1 0 0.0 0.00 1.0e+00 TCF7L2
Ever smoked 1.31 2 0 0.0 0.00 1.0e+00 DCLRE1B GPBP1L1
Basal metabolic rate 2.24 16 9 27.3 0.14 5.9e-01 ADCY9 CBX8 CYBRD1 EFEMP2 FAM189B GATAD2A MAN2C1 MLLT10 PIDD RIN3 RP11-73O6.3 RP11-848P1.7 SDHA SYNE1 UQCRQ ZBTB38
Leg fat percentage (left) 1.64 6 6 18.2 -0.09 8.6e-01 ADCY3 C22orf23 GPBP1L1 MLLT10 RIN3 TCF7L2
Arm fat-free mass (left) 2.31 14 9 27.3 0.07 8.1e-01 ADCY9 ANKLE1 CBX8 CYBRD1 EFEMP2 FAM189B MAN2C1 MKL1 MLLT10 RIN3 RP11-73O6.3 RP11-848P1.7 SYNE1 ZBTB38
Number of operations (self-reported) 1.22 1 0 0.0 0.00 1.0e+00 MLLT10
Irritability 1.22 3 1 3.0 0.00 1.0e+00 LRRC37A4P RP11-73O6.3 TOX3
Ever had prostate specific antigen (PSA) test 1.31 1 0 0.0 0.00 1.0e+00 ZBTB38
Diastolic blood pressure, automated reading 1.45 5 3 9.1 -0.52 3.7e-01 MKL1 MLLT10 TNNT3 TNRC6B ULK3
Myopia 1.19 1 0 0.0 0.00 1.0e+00 GATAD2A
Vascular/heart problems diagnosed by doctor 1.52 5 3 9.1 -0.07 9.1e-01 HSPA4 MLLT10 NEK10 TNNT3 ULK3
Cholesterol lowering medication 1.03 1 0 0.0 0.00 1.0e+00 TCF7L2
Pain experienced in last month 1.18 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Basal cell carcinoma (self-reported) 1.85 2 2 6.1 0.00 1.0e+00 ALS2CR12 CDKN2B
Heart attack/myocardial infarction (self-reported) 1.04 1 0 0.0 0.00 1.0e+00 CDKN2B
Alcohol drinker status: Previous 1.01 1 0 0.0 0.00 1.0e+00 IER2
Impedance of whole body 1.74 16 13 39.4 0.50 4.7e-02 ADCY3 ANKLE1 CBX8 CYBRD1 EFEMP2 FAM189B GATAD2A LRRC37A4P MKL1 NAGLU NRBF2 PIDD RIN3 RP11-196G18.24 RP11-73O6.3 TNRC6B
Leg fat mass (left) 1.67 9 8 24.2 -0.14 7.1e-01 ADCY3 BAIAP2L2 C22orf23 EFEMP2 MLLT10 RP11-73O6.3 SDHA TCF7L2 ZBTB38
Arm predicted mass (left) 2.31 13 9 27.3 0.16 6.1e-01 ADCY9 CBX8 CYBRD1 EFEMP2 FAM189B MAN2C1 MKL1 MLLT10 RIN3 RP11-73O6.3 RP11-848P1.7 SYNE1 ZBTB38

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 32 0.962 2.58
GTEx Adipose Visceral Omentum 22 1.135 2.79
GTEx Adrenal Gland 14 1.006 2.66
GTEx Artery Aorta 34 1.199 2.72
GTEx Artery Coronary 20 1.759 2.80
GTEx Artery Tibial 42 1.179 2.63
GTEx Brain Caudate basal ganglia 13 1.466 2.91
GTEx Brain Cerebellar Hemisphere 16 1.120 2.73
GTEx Brain Cerebellum 25 1.310 2.74
GTEx Brain Cortex 16 1.590 2.88
GTEx Brain Frontal Cortex BA9 16 1.800 3.16
GTEx Brain Hippocampus 7 1.397 2.82
GTEx Brain Hypothalamus 9 1.562 2.99
GTEx Brain Nucleus accumbens basal ganglia 14 1.693 3.07
GTEx Brain Putamen basal ganglia 11 1.852 3.34
GTEx Breast Mammary Tissue 32 1.694 2.87
GTEx Breast Mammary Tissue (Male) 20 1.762 2.89
GTEx Breast Mammary Tissue (Female) 20 1.282 2.75
GTEx Cells EBV-transformed lymphocytes 22 1.620 2.76
GTEx Cells Transformed fibroblasts 38 0.949 2.52
GTEx Colon Sigmoid 22 1.586 2.80
GTEx Colon Transverse 28 1.416 2.73
GTEx Esophagus Gastroesophageal Junction 14 1.007 2.58
GTEx Esophagus Mucosa 37 1.164 2.65
GTEx Esophagus Muscularis 35 1.138 2.70
GTEx Heart Atrial Appendage 21 1.384 2.83
GTEx Heart Left Ventricle 15 1.022 2.64
GTEx Liver 8 1.166 2.65
GTEx Lung 33 1.204 2.75
GTEx Muscle Skeletal 30 1.087 2.59
GTEx Nerve Tibial 41 0.996 2.55
GTEx Ovary 11 1.257 2.56
GTEx Pancreas 22 1.411 2.76
GTEx Pituitary 12 1.117 2.56
GTEx Prostate 11 1.370 2.63
GTEx Skin Not Sun Exposed Suprapubic 26 1.110 2.65
GTEx Skin Sun Exposed Lower leg 37 1.064 2.63
GTEx Small Intestine Terminal Ileum 9 2.045 2.75
GTEx Spleen 24 1.766 3.07
GTEx Stomach 24 1.725 2.89
GTEx Testis 38 1.268 2.63
GTEx Thyroid 48 1.254 2.62
GTEx Uterus 7 1.282 2.67
GTEx Vagina 9 1.493 2.71
GTEx Whole Blood 28 1.465 2.81
METSIM Adipose 31 0.710 2.25
NTR Blood 18 0.797 2.29
ROSMAP Brain Pre-frontal Cortex 21 0.489 2.20
YFS Blood 30 0.688 2.18
CommonMind Brain Pre-frontal Cortex 41 0.802 2.23
TCGA Breast Tumor 9 1.241 2.86
TCGA Breast Normal 35 0.867 2.55
TCGA Ovarian Tumor 9 0.320 1.92
TCGA Prostate Tumor 26 0.790 2.39