Hub : Traits :

Hypothyroidism (self reported)

691 significantly associated models · 233 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 3261925 3 2 1.0e-08 2.3e-11 2.6e-07 41 MMEL1 SDF4
2 1 7715776 9571422 2 1 1.6e-07 2.2e-07 1.0e+00 100 RP5-1115A15.1
3 1 18932744 20503710 3 2 3.7e-11 9.1e-12 5.3e-01 99 CAPZB PQLC2
4 1 23431777 24861704 1 1 5.3e-08 3.3e-07 5.6e-02 86 HMGCL
5 1 25062149 26522518 1 1 4.0e-07 3.4e-10 8.5e-06 50 TMEM57
6 1 37577214 39186794 6 1 3.0e-11 1.9e-10 5.5e-01 99 INPP5B
7 1 107418424 109188382 1 1 1.5e-50 7.7e-51 1.0e+00 100 VAV3
8 1 113236087 115222434 10 10 5.6e-74 9.7e-176 NaN NaN AP4B1 AP4B1-AS1 DCLRE1B OLFML3 PHTF1 PTPN22 RSBN1
9 1 151129254 152518294 1 1 1.8e-07 2.0e-06 8.0e-03 69 THEM5
10 1 156078249 157482371 1 1 7.4e-08 6.5e-08 3.4e-01 97 SH2D2A
11 1 166702558 168182443 1 1 7.1e-08 2.0e-08 1.0e+00 100 CD247
12 2 61725501 63149557 1 1 3.1e-08 4.2e-09 1.0e+00 100 B3GNT2
13 2 97098095 99306504 7 1 2.1e-09 1.2e-09 1.3e-01 94 ANKRD36B
14 2 159476732 161259685 3 1 9.2e-08 1.8e-07 1.0e+00 100 AC009961.3
15 2 161297929 162790882 1 1 2.2e-09 3.4e-09 1.0e+00 100 TANK
16 2 190521054 192712723 6 2 5.0e-14 1.9e-38 7.6e-24 40 NAB1 STAT4
17 2 204051009 205434906 1 1 2.0e-08 2.4e-83 5.7e-80 4 CTLA4
18 2 241563169 243048760 4 2 5.5e-10 4.4e-09 2.5e-02 86 AC114730.7 SEPT2
19 3 11350553 12928762 2 1 1.2e-15 8.0e-14 4.1e-01 99 TIMP4
20 3 36339386 38174470 4 1 9.5e-09 1.2e-08 3.5e-01 97 LRRFIP2
21 3 47681881 49035885 2 1 3.3e-07 2.7e-06 3.6e-03 62 NME6
22 3 104683753 106283820 1 1 2.6e-07 1.8e-18 3.4e-19 -4 CBLB
23 3 168789705 170185994 1 1 5.2e-09 4.4e-07 4.8e-02 85 ARPM1
24 3 191820205 193330022 1 1 5.5e-08 6.3e-08 1.0e+00 100 MB21D2
25 4 86236934 89008506 5 2 4.0e-10 1.1e-09 1.0e+00 100 AFF1 PTPN13
26 4 122961964 124352460 1 1 1.7e-07 3.9e-09 6.6e-03 79 BBS12
27 4 148303195 150060844 1 1 7.8e-32 2.0e-32 1.0e+00 100 NR3C2
28 5 68089764 68828296 2 1 1.6e-07 1.6e-06 5.5e-01 98 GTF2H2C
29 5 71557313 73125146 2 1 1.5e-08 1.2e-08 3.4e-06 34 FCHO2
30 5 75669474 77412011 2 1 1.2e-11 2.3e-13 3.4e-03 84 PDE8B
31 5 101392473 103244640 2 1 3.7e-10 2.1e-11 1.2e-02 86 PAM
32 6 34065982 35542476 1 1 7.5e-08 2.7e-10 2.8e-08 23 UHRF1BP1
33 6 89666956 91704536 2 2 3.0e-33 1.5e-38 2.0e-08 81 BACH2 MDN1
34 6 108994161 110396540 1 1 7.5e-08 2.8e-06 1.6e-03 54 CD164
35 6 134905567 136727603 3 1 5.9e-09 1.9e-09 2.6e-02 86 AHI1
36 6 165045334 167841508 5 2 8.1e-36 2.6e-34 1.0e+00 100 PDE10A RNASET2
37 7 43910682 45312179 1 1 1.5e-07 2.6e-07 2.2e-01 94 DDX56
38 7 76506844 77966572 1 1 1.4e-07 9.6e-08 1.9e-01 94 PTPN12
39 7 99591418 100979310 1 1 2.8e-11 7.9e-11 1.0e+00 100 GIGYF1
40 7 127878155 129284182 1 1 2.9e-07 5.9e-08 3.4e-04 56 IRF5
41 8 22687572 24125172 1 1 3.2e-07 9.2e-08 2.8e-02 83 SLC25A37
42 8 60736025 62477554 2 1 2.3e-10 4.7e-10 1.0e+00 100 RAB2A
43 8 128107136 129812343 1 1 1.5e-07 9.1e-14 7.4e-14 -1 PVT1
44 8 132897005 134846363 4 2 1.2e-12 3.2e-16 1.6e-05 72 TG
45 8 140969818 142706843 1 1 2.3e-07 1.9e-10 9.7e-06 52 PTK2
46 9 4758022 6168335 1 1 9.3e-08 2.7e-11 3.3e-08 31 CD274
47 9 99581811 101652673 6 8 1.3e-67 6.6e-103 NaN NaN C9orf156 TMOD1 TSTD2
48 9 122881960 124331465 4 1 1.3e-07 4.3e-07 1.0e+00 100 PSMD5
49 9 126321003 127872298 2 1 2.9e-09 1.3e-08 5.9e-01 99 NEK6
50 9 130769800 132289479 2 1 8.4e-09 8.5e-09 1.0e+00 100 PKN3
51 10 4999536 6677767 3 2 8.2e-19 4.7e-19 2.2e-02 94 FAM208B FBXO18
52 10 16986810 18453209 1 1 3.4e-07 1.7e-06 9.1e-01 100 STAM
53 10 63253359 64724096 1 1 1.5e-17 2.1e-30 2.0e-28 7 RTKN2
54 10 123438113 124914082 2 1 7.7e-14 6.7e-14 1.0e+00 100 PLEKHA1
55 11 198510 1346802 8 2 9.8e-09 9.1e-10 1.1e-02 83 DRD4 RP11-326C3.11
56 11 34460769 35949179 1 1 9.6e-08 9.8e-19 6.5e-13 34 CD44
57 11 46622392 48028343 1 1 6.7e-08 3.5e-07 9.6e-03 74 MADD
58 11 60549966 62346131 7 1 1.8e-11 3.0e-11 2.4e-01 97 TMEM258
59 11 63316786 64820283 2 1 1.1e-10 8.8e-11 1.0e+00 100 CCDC88B
60 11 93166368 94613754 1 1 2.3e-07 6.4e-09 5.7e-04 65 PANX1
61 11 116007539 117800682 4 2 1.2e-07 3.1e-11 6.6e-03 83 AP006216.12 SIK3
62 12 55601472 57681122 7 1 6.5e-18 4.4e-15 3.7e-02 93 SUOX
63 12 109641978 113517494 22 9 8.8e-71 6.4e-117 NaN NaN AC003029.1 ADAM1A ALDH2 HECTD4 HVCN1 VPS29
64 13 23856997 25579336 1 1 5.6e-08 3.0e-40 2.9e-35 13 SPATA13
65 13 42149812 43594717 1 1 3.9e-07 8.6e-14 2.5e-08 44 AKAP11
66 15 38088200 39556796 1 1 5.1e-15 4.7e-17 1.5e-04 80 RASGRP1
67 16 49488151 51097687 3 2 2.6e-10 6.0e-10 7.4e-01 100 BRD7
68 16 66666637 69084178 15 1 9.3e-11 3.8e-11 1.2e-02 86 ATP6V0D1
69 17 6190353 7949434 2 1 2.2e-08 1.0e-13 3.7e-07 53 ACAP1
70 17 27222988 28629763 1 1 2.0e-07 1.7e-06 3.6e-01 96 ANKRD13B
71 17 39570442 41265776 3 1 1.0e-12 1.9e-12 1.0e+00 100 KAT2A
72 17 44788310 46704536 7 4 6.7e-16 7.4e-16 5.4e-01 99 EFCAB13 MRPL10 NPEPPS RP11-6N17.3
73 17 73175294 74574103 1 1 1.1e-07 4.6e-07 8.1e-02 88 RP11-552F3.9
74 18 12090696 13687136 2 2 4.3e-08 4.0e-12 9.8e-04 77 PTPN2
75 18 66371289 68204223 1 1 2.0e-08 3.2e-09 1.0e+00 100 DOK6
76 19 4118871 5533326 2 1 1.0e-12 1.5e-23 5.1e-13 48 TICAM1
77 19 9763152 11186711 1 1 1.1e-07 1.8e-11 1.4e-05 58 TYK2
78 19 17672385 19190906 3 1 3.2e-13 2.6e-13 1.0e+00 100 LRRC25
79 19 48525507 50909389 5 3 7.0e-13 7.0e-12 1.0e+00 100 ALDH16A1 CPT1C RASIP1
80 22 36867133 38292974 2 2 5.4e-22 6.6e-31 6.9e-05 88 C1QTNF6
81 22 41071659 42633054 3 1 1.2e-07 1.5e-08 1.0e+00 100 TEF

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.34 8 3 9.1 0.02 9.7e-01 AP4B1-AS1 CCDC88B CPT1C DCLRE1B RASGRP1 RASIP1 RNASET2 TMEM258
Irritable Bowel Disease (IBD) 1.96 9 1 3.0 -0.68 4.3e-02 BBS12 BRD7 CCDC88B CPT1C HECTD4 KAT2A PTPN2 RNASET2 SDF4
Ulcerative Colitis (UC) 1.69 2 2 6.1 0.00 1.0e+00 IRF5 MMEL1
Reaction Time 1.51 2 2 6.1 0.00 1.0e+00 AC003029.1 HECTD4
Verbal and Numeric Reasoning (VNR) 1.23 4 1 3.0 -0.40 6.0e-01 MADD SUOX TANK TMEM258
Breast Cancer 1.11 2 1 3.0 0.00 1.0e+00 AP4B1 DCLRE1B
Ovarian Cancer 1.02 1 0 0.0 0.00 1.0e+00 ATP6V0D1
Body Mass Index (BMI) (2010) 1.43 1 1 3.0 0.00 1.0e+00 MADD
Coronary Artery Disease (CAD) 1.86 3 0 0.0 0.86 1.4e-01 HECTD4 INPP5B VPS29
Crohns Disease (2012) 2.00 5 1 3.0 0.76 1.3e-01 CCDC88B RASGRP1 RASIP1 RNASET2 TMEM258
Fasting Glucose 1.18 1 1 3.0 0.00 1.0e+00 TMEM258
HbA1C 0.95 1 0 0.0 0.00 1.0e+00 ADAM1A
HDL Cholesterol 2.20 6 5 15.2 -0.39 4.5e-01 AFF1 AP006216.12 ATP6V0D1 MADD TMEM258 UHRF1BP1
LDL Cholesterol 2.16 4 3 9.1 -0.24 7.0e-01 AC003029.1 HECTD4 RASIP1 TMEM258
Lupus 3.79 7 3 9.1 0.68 6.6e-02 AHI1 DCLRE1B DRD4 HECTD4 IRF5 NAB1 RTKN2
Neuroticism 0.98 1 0 0.0 0.00 1.0e+00 TANK
Primary Biliary Cirrhosis 2.91 5 2 6.1 0.58 2.3e-01 CCDC88B HECTD4 IRF5 MMEL1 NAB1
Rheumatoid Arthritis 7.00 16 9 27.3 0.95 2.3e-09 AP4B1 AP4B1-AS1 DCLRE1B FAM208B HECTD4 INPP5B IRF5 MMEL1 NAB1 OLFML3 PAM PHTF1 PTPN2 PTPN22 RASGRP1 RSBN1
Schizophrenia 1.19 3 1 3.0 0.00 1.0e+00 DDX56 GIGYF1 RP5-1115A15.1
Triglycerides 1.89 2 1 3.0 0.00 1.0e+00 AFF1 TMEM258
Ulcerative Colitis 1.63 3 0 0.0 0.00 1.0e+00 BRD7 IRF5 MMEL1
Blood Eosinophil Count 6.87 43 34 103.0 0.53 1.4e-04 AC003029.1 AC114730.7 ACAP1 ADAM1A AKAP11 ALDH2 ARPM1 B3GNT2 BACH2 BBS12 C1QTNF6 CCDC88B CD247 CTLA4 DOK6 EFCAB13 FAM208B FBXO18 FCHO2 GIGYF1 HECTD4 HMGCL HVCN1 IRF5 LRRC25 MDN1 MMEL1 NAB1 NEK6 NPEPPS PSMD5 PTPN2 PVT1 RASGRP1 RP5-1115A15.1 SEPT2 SIK3 STAT4 SUOX TEF TIMP4 TMEM258 VPS29
Blood Platelet Count 4.17 31 20 60.6 0.31 5.6e-02 ACAP1 ADAM1A AFF1 C1QTNF6 C9orf156 CAPZB CTLA4 DOK6 FCHO2 HECTD4 HVCN1 IRF5 MRPL10 NAB1 NEK6 PAM PKN3 PSMD5 PTK2 PTPN13 RASIP1 RP11-552F3.9 SH2D2A SLC25A37 TEF TIMP4 TMEM258 TMOD1 TYK2 UHRF1BP1 VPS29
Blood Red Count 2.04 25 19 57.6 0.38 4.1e-02 AC003029.1 ADAM1A AFF1 ANKRD13B ATP6V0D1 BACH2 C9orf156 CBLB CD164 CPT1C GIGYF1 HECTD4 HMGCL HVCN1 MDN1 NAB1 NPEPPS PAM PKN3 RP11-6N17.3 SEPT2 SUOX TG TMEM258 VPS29
Blood White Count 3.63 33 26 78.8 0.41 1.2e-02 AC003029.1 AC009961.3 ACAP1 ADAM1A AFF1 AHI1 ALDH2 ANKRD13B AP4B1 ATP6V0D1 BACH2 DCLRE1B DOK6 GTF2H2C HECTD4 HVCN1 KAT2A MADD OLFML3 PAM PDE8B PHTF1 PKN3 PSMD5 PVT1 RAB2A RP11-326C3.11 RP5-1115A15.1 SEPT2 TIMP4 TMEM258 TYK2 VPS29
Heel T-Score 1.34 16 12 36.4 -0.25 3.5e-01 AFF1 AKAP11 ANKRD13B BACH2 CAPZB CCDC88B FCHO2 INPP5B IRF5 MADD NAB1 NEK6 RP11-326C3.11 RP5-1115A15.1 TEF TMEM258
BMI 1.29 13 6 18.2 -0.05 8.8e-01 ANKRD13B CTLA4 HECTD4 LRRC25 MADD NEK6 PTPN12 RP11-552F3.9 SIK3 SLC25A37 SUOX UHRF1BP1 VPS29
Height 1.00 32 25 75.8 -0.23 1.6e-01 AC003029.1 ADAM1A ATP6V0D1 C9orf156 CAPZB CD164 CPT1C EFCAB13 HECTD4 HVCN1 INPP5B IRF5 KAT2A LRRFIP2 MADD NAB1 NME6 NPEPPS NR3C2 PAM PLEKHA1 PQLC2 PSMD5 PTPN12 PTPN13 RASIP1 RP5-1115A15.1 SEPT2 TG TMEM258 TMEM57 UHRF1BP1
Waist Hip Ratio (WHR) 1.58 10 8 24.2 -0.09 8.1e-01 ACAP1 ADAM1A ATP6V0D1 BBS12 LRRC25 PAM PTPN12 RASIP1 TIMP4 UHRF1BP1
Systolic Blood Pressure 1.88 16 12 36.4 0.52 3.3e-02 AC003029.1 ADAM1A HECTD4 HMGCL HVCN1 NAB1 NEK6 NME6 PSMD5 PTPN12 PTPN13 RASIP1 RP11-552F3.9 RP5-1115A15.1 TMEM57 VPS29
Smoking Status 1.41 7 3 9.1 0.11 8.1e-01 ADAM1A CCDC88B DCLRE1B PHTF1 RP5-1115A15.1 SUOX TANK
Allergy or Eczema 3.10 17 13 39.4 -0.18 4.8e-01 AC114730.7 ADAM1A AHI1 BACH2 BBS12 CD247 FBXO18 HECTD4 MDN1 NEK6 PSMD5 PTPN2 RP5-1115A15.1 SDF4 SIK3 SUOX TEF
Cardiovascular Disease 1.92 15 6 18.2 0.73 1.4e-03 AC003029.1 ADAM1A ANKRD13B CCDC88B HECTD4 MADD NME6 RASIP1 RP11-552F3.9 RP11-6N17.3 RP5-1115A15.1 SUOX TMEM57 UHRF1BP1 VPS29
Respiratory disease 2.92 12 8 24.2 0.02 9.5e-01 AC114730.7 BACH2 BBS12 CD247 FAM208B FBXO18 NEK6 RP11-552F3.9 RP5-1115A15.1 SUOX TEF TMEM258
Type 2 Diabetes (T2D) 1.03 1 0 0.0 0.00 1.0e+00 ADAM1A
Lung FEV1/FVC ratio 1.56 14 8 24.2 -0.36 1.8e-01 AC009961.3 ANKRD13B ATP6V0D1 C9orf156 CTLA4 HVCN1 LRRC25 PLEKHA1 PQLC2 RASIP1 RP11-326C3.11 RP5-1115A15.1 SEPT2 SUOX
Lung FVC 0.96 11 2 6.1 0.36 2.6e-01 AFF1 AHI1 ANKRD13B AP4B1 HECTD4 KAT2A LRRC25 MADD PDE8B PLEKHA1 SUOX
Neuroticism 1.19 3 0 0.0 0.00 1.0e+00 RP5-1115A15.1 TEF TIMP4
Chronotype (morning person) 1.42 5 1 3.0 0.23 7.1e-01 AC003029.1 HECTD4 MADD NEK6 TIMP4
Hair Pigment 0.49 17 9 27.3 0.29 1.9e-01 AC003029.1 ATP6V0D1 C9orf156 EFCAB13 GIGYF1 HECTD4 MADD MRPL10 PSMD5 RP11-326C3.11 RP11-552F3.9 RP5-1115A15.1 SDF4 SUOX TEF TMEM258 TSTD2
Tanning 0.18 2 0 0.0 0.00 1.0e+00 HECTD4 LRRC25
Hand grip strength (left) 0.81 1 0 0.0 0.00 1.0e+00 MADD
Number of treatments/medications taken 2.18 7 1 3.0 -0.94 4.1e-04 ADAM1A DCLRE1B FAM208B HECTD4 RNASET2 TANK TMEM258
Average weekly spirits intake 1.30 1 0 0.0 0.00 1.0e+00 RASIP1
Frequency of depressed mood in last 2 weeks 1.07 2 0 0.0 0.00 1.0e+00 KAT2A RP5-1115A15.1
Hearing difficulty/problems: Yes 0.90 1 0 0.0 0.00 1.0e+00 PTK2
Relative age of first facial hair 0.93 2 0 0.0 0.00 1.0e+00 CTLA4 MRPL10
Ever used hormone-replacement therapy (HRT) 1.03 1 0 0.0 0.00 1.0e+00 NEK6
Systolic blood pressure, automated reading 1.35 7 2 6.1 -0.56 1.5e-01 AC003029.1 HECTD4 NAB1 NEK6 NME6 RASIP1 RP5-1115A15.1
Angina 1.31 1 0 0.0 0.00 1.0e+00 ANKRD13B
Impedance of leg (right) 1.00 10 5 15.2 0.54 1.0e-01 ATP6V0D1 FCHO2 HVCN1 LRRC25 MADD PAM PTK2 PTPN13 SUOX UHRF1BP1
Leg fat-free mass (left) 1.25 15 8 24.2 0.09 7.4e-01 ALDH2 EFCAB13 HECTD4 HVCN1 INPP5B MADD PLEKHA1 PTK2 PTPN12 PTPN13 SEPT2 SLC25A37 SUOX UHRF1BP1 VPS29
Trunk fat percentage 1.49 11 5 15.2 -0.32 3.3e-01 ANKRD13B CD44 LRRC25 LRRFIP2 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 TEF UHRF1BP1
Current tobacco smoking 1.32 2 0 0.0 0.00 1.0e+00 RP5-1115A15.1 TEF
Fed-up feelings 1.34 3 1 3.0 0.85 1.5e-01 CCDC88B HECTD4 TEF
Taking other prescription medications 3.40 7 4 12.1 -0.96 2.1e-04 ADAM1A CCDC88B DCLRE1B FAM208B HECTD4 KAT2A RNASET2
Age when periods started (menarche) 1.16 2 1 3.0 0.00 1.0e+00 MADD SUOX
Heel bone mineral density (BMD) T-score, automated (left) 1.16 3 2 6.1 0.00 1.0e+00 AKAP11 ANKRD13B RP5-1115A15.1
High blood pressure 1.74 11 2 6.1 -0.37 2.3e-01 AC003029.1 ADAM1A HECTD4 MADD NME6 PTPN12 RASIP1 RP5-1115A15.1 RTKN2 SUOX TMEM57
Hayfever, allergic rhinitis or eczema 2.80 14 8 24.2 0.13 6.7e-01 AC114730.7 ADAM1A AHI1 BACH2 BBS12 CD247 FBXO18 HECTD4 NEK6 PSMD5 RP5-1115A15.1 SDF4 SUOX TEF
Medication: Atenolol 1.64 1 1 3.0 0.00 1.0e+00 HECTD4
Medication: Levothyroxine sodium 17.78 71 38 115.2 -0.99 2.8e-77 AC003029.1 AC009961.3 ACAP1 ADAM1A AHI1 AKAP11 ALDH16A1 ANKRD36B AP4B1 AP4B1-AS1 ARPM1 ATP6V0D1 B3GNT2 BACH2 BRD7 C1QTNF6 C9orf156 CAPZB CCDC88B CD164 CPT1C CTLA4 DCLRE1B DOK6 DRD4 EFCAB13 FAM208B FBXO18 FCHO2 GIGYF1 HECTD4 HVCN1 INPP5B KAT2A LRRC25 LRRFIP2 MDN1 MMEL1 MRPL10 NAB1 NPEPPS NR3C2 OLFML3 PAM PDE8B PHTF1 PLEKHA1 PTPN2 PTPN22 RAB2A RASGRP1 RNASET2 RP5-1115A15.1 RSBN1 RTKN2 SDF4 SEPT2 SH2D2A STAM STAT4 SUOX TG TICAM1 TIMP4 TMEM258 TMEM57 TMOD1 TSTD2 UHRF1BP1 VAV3 VPS29
Sitting height 0.85 14 8 24.2 -0.09 7.3e-01 C9orf156 CAPZB CD164 DRD4 INPP5B MADD PLEKHA1 PTK2 PTPN12 PTPN13 RASIP1 SEPT2 TMEM258 UHRF1BP1
Body mass index (BMI) 1.27 9 3 9.1 -0.12 7.7e-01 ANKRD13B HECTD4 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 SUOX UHRF1BP1
Impedance of leg (left) 0.93 7 4 12.1 0.49 2.6e-01 LRRC25 MADD PAM PTK2 PTPN13 SUOX UHRF1BP1
Leg predicted mass (left) 1.25 16 8 24.2 0.11 6.6e-01 ALDH2 CD164 EFCAB13 HECTD4 HVCN1 INPP5B MADD PLEKHA1 PTK2 PTPN12 PTPN13 SEPT2 SLC25A37 SUOX UHRF1BP1 VPS29
Trunk fat mass 1.48 11 5 15.2 -0.45 1.6e-01 ANKRD13B LRRC25 LRRFIP2 MADD PLEKHA1 PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 TEF UHRF1BP1
Waist circumference 1.39 5 3 9.1 -0.32 6.0e-01 ANKRD13B LRRC25 MADD SLC25A37 UHRF1BP1
Past tobacco smoking 1.46 6 0 0.0 0.16 7.6e-01 ADAM1A DCLRE1B HECTD4 PHTF1 SUOX TANK
Forced vital capacity (FVC) 0.96 5 2 6.1 0.14 8.3e-01 ANKRD13B INPP5B MADD PLEKHA1 SEPT2
Heel bone mineral density (BMD) T-score, automated (right) 1.24 6 1 3.0 -0.29 5.8e-01 AKAP11 ANKRD13B CAPZB NEK6 RP5-1115A15.1 TMEM258
Ever unenthusiastic/disinterested for a whole week 1.23 1 0 0.0 0.00 1.0e+00 TIMP4
Qualifications: None of the above 1.07 2 0 0.0 0.00 1.0e+00 SUOX TANK
Mouth/teeth dental problems 1.30 2 0 0.0 0.00 1.0e+00 DDX56 RASIP1
Heart attack 1.33 1 0 0.0 0.00 1.0e+00 ANKRD13B
Allergy 2.76 12 8 24.2 0.02 9.5e-01 AC114730.7 ADAM1A AHI1 BACH2 BBS12 CD247 FBXO18 NEK6 PSMD5 RP5-1115A15.1 SUOX TEF
Diabetes (self-reported) 1.09 1 0 0.0 0.00 1.0e+00 DCLRE1B
Hayfever/allergic rhinitis (self-reported) 2.20 3 2 6.1 0.00 1.0e+00 AC114730.7 CD247 SUOX
Medication: Ramipril 1.23 1 0 0.0 0.00 1.0e+00 ADAM1A
Medication: Simvastatin 1.20 1 0 0.0 0.00 1.0e+00 RASIP1
Fluid intelligence score 1.19 3 1 3.0 0.00 1.0e+00 MADD TANK TMEM258
Illnesses of siblings 1.48 3 0 0.0 0.93 7.3e-02 ADAM1A ANKRD13B HECTD4
Neuroticism score 1.22 3 1 3.0 0.00 1.0e+00 RP5-1115A15.1 TEF TIMP4
Weight 1.41 11 8 24.2 0.18 5.7e-01 HECTD4 HVCN1 MADD PLEKHA1 PTPN12 RP11-552F3.9 SEPT2 SLC25A37 SUOX UHRF1BP1 VPS29
Impedance of arm (right) 1.25 15 8 24.2 -0.03 9.3e-01 ADAM1A AHI1 BBS12 HECTD4 HVCN1 LRRC25 NEK6 NR3C2 PTK2 PTPN13 RTKN2 SUOX TEF UHRF1BP1 VPS29
Arm fat percentage (right) 1.33 7 4 12.1 -0.32 4.9e-01 ANKRD13B LRRC25 MADD RP11-552F3.9 RP5-1115A15.1 SLC25A37 UHRF1BP1
Trunk fat-free mass 1.27 17 8 24.2 0.35 1.5e-01 AC003029.1 ADAM1A ALDH2 CD164 HECTD4 HVCN1 INPP5B LRRC25 NEK6 PLEKHA1 PTK2 PTPN13 RASIP1 SEPT2 SUOX UHRF1BP1 VPS29
Hip circumference 1.61 12 6 18.2 0.13 6.7e-01 AC003029.1 EFCAB13 HECTD4 MADD PLEKHA1 PTPN12 RASIP1 RP11-552F3.9 SEPT2 SLC25A37 UHRF1BP1 VPS29
Alcohol intake versus 10 years previously 0.96 1 0 0.0 0.00 1.0e+00 RASIP1
Father's age at death 1.25 1 0 0.0 0.00 1.0e+00 HECTD4
Worrier / anxious feelings 0.98 2 0 0.0 0.00 1.0e+00 PAM TEF
Frequency of tiredness / lethargy in last 2 weeks 1.14 2 0 0.0 0.00 1.0e+00 RP5-1115A15.1 TEF
Falls in the last year 1.09 1 0 0.0 0.00 1.0e+00 PTK2
Hair/balding pattern: Pattern 3 0.98 1 0 0.0 0.00 1.0e+00 MRPL10
Number of live births 1.22 1 0 0.0 0.00 1.0e+00 TMEM258
Forced expiratory volume in 1-second (FEV1) 0.98 2 1 3.0 0.00 1.0e+00 MADD SUOX
Pulse rate 1.45 2 2 6.1 0.00 1.0e+00 GIGYF1 TMEM258
Qualifications: A levels/AS levels or equivalent 1.05 2 1 3.0 0.00 1.0e+00 SUOX TANK
Mouth/teeth dental problems: Dentures 1.07 1 1 3.0 0.00 1.0e+00 RASIP1
Asthma 2.64 9 6 18.2 0.04 9.1e-01 AC114730.7 AHI1 BACH2 BBS12 CD247 RP5-1115A15.1 SUOX TEF TMEM258
Medication: Ibuprofen (e.g. Nurofen) 1.27 1 0 0.0 0.00 1.0e+00 HECTD4
Medication: Cholesterol lowering 1.19 1 1 3.0 0.00 1.0e+00 RASIP1
Depression (self-reported) 1.11 1 0 0.0 0.00 1.0e+00 RP5-1115A15.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.91 2 1 3.0 0.00 1.0e+00 MADD SUOX
Pulse wave Arterial Stiffness index 1.54 1 1 3.0 0.00 1.0e+00 ADAM1A
Impedance of arm (left) 1.22 12 8 24.2 -0.25 4.2e-01 ADAM1A AHI1 BBS12 HECTD4 HVCN1 LRRC25 NEK6 PTPN13 SUOX TEF UHRF1BP1 VPS29
Arm fat mass (right) 1.37 10 3 9.1 -0.04 9.2e-01 ANKRD13B HECTD4 LRRC25 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 SUOX UHRF1BP1
Trunk predicted mass 1.28 17 8 24.2 0.35 1.5e-01 AC003029.1 ADAM1A ALDH2 CD164 HECTD4 HVCN1 INPP5B LRRC25 NEK6 PLEKHA1 PTK2 PTPN13 RASIP1 SEPT2 SUOX UHRF1BP1 VPS29
Standing height 0.97 22 12 36.4 0.14 4.8e-01 ATP6V0D1 C9orf156 CAPZB CD164 EFCAB13 HECTD4 HVCN1 INPP5B KAT2A LRRFIP2 MADD NAB1 NPEPPS PLEKHA1 PSMD5 PTPN12 PTPN13 RASIP1 RP5-1115A15.1 SEPT2 TMEM258 UHRF1BP1
Breastfed as a baby 1.16 1 0 0.0 0.00 1.0e+00 NEK6
Tense / 'highly strung' 1.15 3 1 3.0 0.00 1.0e+00 RP5-1115A15.1 TEF TIMP4
Hair/balding pattern: Pattern 4 0.82 3 3 9.1 0.00 1.0e+00 ATP6V0D1 RP5-1115A15.1 TMEM258
Birth weight of first child 2.04 8 3 9.1 0.53 1.4e-01 AC003029.1 ADAM1A FCHO2 HECTD4 HVCN1 RAB2A SLC25A37 SUOX
Peak expiratory flow (PEF) 1.11 3 0 0.0 0.00 1.0e+00 PQLC2 RASIP1 SDF4
Medication for cholesterol, blood pressure or diabetes 1.28 1 0 0.0 0.00 1.0e+00 RASIP1
Gout (self-reported) 1.29 1 0 0.0 0.00 1.0e+00 HECTD4
Hypothyroidism/myxoedema (self-reported) 20.58 96 59 178.8 -1.00 2.4e-124 AC003029.1 AC009961.3 AC114730.7 ACAP1 ADAM1A AFF1 AHI1 AKAP11 ALDH16A1 ANKRD36B AP4B1 AP4B1-AS1 ARPM1 ATP6V0D1 B3GNT2 BACH2 BBS12 BRD7 C1QTNF6 C9orf156 CAPZB CBLB CCDC88B CD164 CD247 CD274 CD44 CPT1C CTLA4 DCLRE1B DOK6 DRD4 EFCAB13 FAM208B FBXO18 FCHO2 GIGYF1 GTF2H2C HECTD4 HMGCL HVCN1 INPP5B IRF5 KAT2A LRRC25 LRRFIP2 MADD MB21D2 MDN1 MMEL1 MRPL10 NAB1 NEK6 NPEPPS NR3C2 OLFML3 PAM PDE8B PHTF1 PKN3 PLEKHA1 PQLC2 PSMD5 PTK2 PTPN12 PTPN13 PTPN2 PTPN22 RAB2A RASGRP1 RNASET2 RP11-326C3.11 RP11-552F3.9 RP11-6N17.3 RP5-1115A15.1 RSBN1 RTKN2 SDF4 SEPT2 SH2D2A SPATA13 STAM STAT4 SUOX TANK TEF TG THEM5 TICAM1 TIMP4 TMEM258 TMOD1 TSTD2 UHRF1BP1 VAV3 VPS29
Medication: Ventolin 100micrograms inhaler 1.77 5 0 0.0 0.63 2.6e-01 AC114730.7 BACH2 CD247 STAM TEF
Birth weight 2.02 9 3 9.1 0.67 3.6e-02 ACAP1 ADAM1A HECTD4 HVCN1 PSMD5 RASIP1 SLC25A37 SUOX VPS29
High blood pressure (siblings) 1.47 1 0 0.0 0.00 1.0e+00 HECTD4
Forced vital capacity (FVC), Best measure 0.89 5 2 6.1 0.15 8.1e-01 ANKRD13B INPP5B MADD PLEKHA1 SEPT2
Body fat percentage 1.47 10 5 15.2 -0.31 3.9e-01 ANKRD13B CD44 LRRC25 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 TEF UHRF1BP1
Leg fat percentage (right) 1.48 9 5 15.2 -0.25 5.2e-01 ANKRD13B LRRC25 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SIK3 SLC25A37 UHRF1BP1
Arm fat-free mass (right) 1.38 15 9 27.3 0.33 2.1e-01 ADAM1A CD164 HECTD4 HVCN1 NEK6 PLEKHA1 PTK2 PTPN12 PTPN13 RASIP1 SEPT2 SLC25A37 SUOX UHRF1BP1 VPS29
Comparative body size at age 10 1.18 4 1 3.0 -0.55 4.5e-01 MADD RASIP1 TEF UHRF1BP1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.16 1 0 0.0 0.00 1.0e+00 TIMP4
Wheeze or whistling in the chest in last year 1.41 4 1 3.0 -0.07 9.3e-01 AC114730.7 CD247 RP5-1115A15.1 TMEM258
Reason for reducing amount of alcohol drunk: Health precaution 1.04 1 0 0.0 0.00 1.0e+00 SUOX
Pulse wave peak to peak time 1.54 1 1 3.0 0.00 1.0e+00 ADAM1A
Qualifications: College or University degree 1.10 5 3 9.1 -0.38 5.2e-01 LRRC25 PAM PTK2 SUOX TANK
Medication for pain relief, constipation, heartburn 1.26 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Neck or shoulder pain in last month 1.06 3 0 0.0 0.00 1.0e+00 NEK6 RP5-1115A15.1 SUOX
Medication: Blood pressure 1.28 2 1 3.0 0.00 1.0e+00 ADAM1A HECTD4
Angina (self-reported) 1.30 1 0 0.0 0.00 1.0e+00 ANKRD13B
Medication: Seretide 50 evohaler 1.47 1 0 0.0 0.00 1.0e+00 AC114730.7
Mean time to correctly identify matches 1.35 2 2 6.1 0.00 1.0e+00 AC003029.1 HECTD4
Whole body fat mass 1.47 9 7 21.2 -0.11 7.8e-01 ANKRD13B HECTD4 LRRC25 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 UHRF1BP1
Leg fat mass (right) 1.51 10 7 21.2 0.09 7.9e-01 ANKRD13B HECTD4 LRRC25 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 UHRF1BP1 VPS29
Arm predicted mass (right) 1.39 15 10 30.3 0.32 2.2e-01 ADAM1A CD164 HECTD4 HVCN1 NEK6 PLEKHA1 PTK2 PTPN12 PTPN13 RASIP1 SEPT2 SLC25A37 SUOX UHRF1BP1 VPS29
Pulse rate, automated reading 1.72 6 3 9.1 0.61 2.0e-01 GIGYF1 NAB1 PSMD5 TMEM258 UHRF1BP1 VPS29
Alcohol intake frequency. 1.03 3 1 3.0 0.00 1.0e+00 NPEPPS RASIP1 SUOX
Comparative height size at age 10 1.27 13 6 18.2 0.63 3.9e-03 ATP6V0D1 C9orf156 CAPZB HECTD4 HVCN1 INPP5B NR3C2 PDE8B PLEKHA1 PTPN13 RASIP1 RP5-1115A15.1 SEPT2
Suffer from 'nerves' 1.37 2 1 3.0 0.00 1.0e+00 MADD RP5-1115A15.1
Overall health rating 1.02 4 0 0.0 -0.58 4.2e-01 DCLRE1B SUOX TANK UHRF1BP1
Hypertension (Self-reported) 1.69 11 3 9.1 -0.33 2.9e-01 AC003029.1 ADAM1A HECTD4 MADD NME6 PTPN12 RASIP1 RP5-1115A15.1 RTKN2 SUOX TMEM57
Smoking status: Previous 1.47 1 0 0.0 0.00 1.0e+00 HECTD4
Whole body fat-free mass 1.28 17 7 21.2 0.26 2.9e-01 ADAM1A ALDH2 CD164 EFCAB13 HECTD4 HVCN1 INPP5B NEK6 PLEKHA1 PTK2 PTPN12 PTPN13 RASIP1 SEPT2 SUOX UHRF1BP1 VPS29
Leg fat-free mass (right) 1.27 14 9 27.3 0.11 6.9e-01 CD164 EFCAB13 HECTD4 HVCN1 INPP5B MADD PLEKHA1 PTK2 PTPN12 PTPN13 SEPT2 SUOX UHRF1BP1 VPS29
Arm fat percentage (left) 1.37 9 5 15.2 -0.34 3.7e-01 ANKRD13B LRRC25 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 TEF UHRF1BP1
Mood swings 1.21 2 1 3.0 0.00 1.0e+00 PTK2 TEF
Loneliness, isolation 1.38 1 0 0.0 0.00 1.0e+00 RP5-1115A15.1
Long-standing illness, disability or infirmity 2.08 4 1 3.0 -0.97 3.0e-02 DCLRE1B FAM208B RASGRP1 RNASET2
Diabetes diagnosed by doctor 1.13 1 0 0.0 0.00 1.0e+00 DCLRE1B
Mouth/teeth dental problems: Mouth ulcers 1.86 3 1 3.0 0.00 1.0e+00 BRD7 IRF5 PAM
Medication for cholesterol 1.55 2 0 0.0 0.00 1.0e+00 HECTD4 RASIP1
Asthma (self-reported) 2.71 10 6 18.2 0.01 9.8e-01 AC114730.7 AHI1 BACH2 BBS12 CD247 FBXO18 RP5-1115A15.1 SUOX TEF TMEM258
Osteoporosis (self-reported) 1.16 1 0 0.0 0.00 1.0e+00 CCDC88B
Smoking status: Current 1.31 1 0 0.0 0.00 1.0e+00 AC003029.1
Whole body water mass 1.28 16 7 21.2 0.24 3.5e-01 ADAM1A ALDH2 CD164 EFCAB13 HECTD4 HVCN1 INPP5B NEK6 PLEKHA1 PTK2 PTPN12 PTPN13 SEPT2 SUOX UHRF1BP1 VPS29
Leg predicted mass (right) 1.27 14 9 27.3 0.11 7.0e-01 CD164 EFCAB13 HECTD4 HVCN1 INPP5B MADD PLEKHA1 PTK2 PTPN12 PTPN13 SEPT2 SUOX UHRF1BP1 VPS29
Arm fat mass (left) 1.39 9 4 12.1 -0.12 7.5e-01 ANKRD13B HECTD4 LRRC25 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 UHRF1BP1
Number of self-reported non-cancer illnesses 2.29 5 1 3.0 -0.95 3.4e-03 FAM208B HECTD4 RASGRP1 RASIP1 RNASET2
Average weekly champagne plus white wine intake 1.21 2 1 3.0 0.00 1.0e+00 SUOX TMEM258
Miserableness 1.26 2 0 0.0 0.00 1.0e+00 RP5-1115A15.1 TANK
Medication: Blood pressure 1.53 4 1 3.0 -0.74 1.6e-01 AC003029.1 ARPM1 HECTD4 RASIP1
High cholesterol (Self-reported) 1.63 3 2 6.1 0.00 1.0e+00 RASIP1 RP11-552F3.9 RP11-6N17.3
Medication: Bendroflumethiazide 1.33 1 0 0.0 0.00 1.0e+00 RASIP1
Medication: Atorvastatin 1.34 1 0 0.0 0.00 1.0e+00 RASIP1
Ever smoked 1.26 2 0 0.0 0.00 1.0e+00 DCLRE1B PHTF1
Basal metabolic rate 1.31 17 7 21.2 0.27 2.8e-01 ADAM1A ALDH2 CD164 EFCAB13 HECTD4 HVCN1 INPP5B PLEKHA1 PTK2 PTPN12 PTPN13 RASIP1 SEPT2 SLC25A37 SUOX UHRF1BP1 VPS29
Leg fat percentage (left) 1.48 10 5 15.2 -0.19 5.9e-01 ANKRD13B CTLA4 LRRC25 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SIK3 SLC25A37 UHRF1BP1
Arm fat-free mass (left) 1.38 16 10 30.3 0.42 9.5e-02 AC003029.1 ADAM1A ALDH2 CD164 HECTD4 HVCN1 NEK6 PLEKHA1 PTPN12 PTPN13 RASIP1 SEPT2 SLC25A37 SUOX UHRF1BP1 VPS29
Number of operations (self-reported) 1.43 4 0 0.0 0.17 8.3e-01 ARPM1 NEK6 RP5-1115A15.1 TANK
Irritability 1.17 2 0 0.0 0.00 1.0e+00 TEF TMEM258
Diastolic blood pressure, automated reading 2.20 10 6 18.2 -0.74 6.3e-03 AC003029.1 ADAM1A AFF1 GIGYF1 HECTD4 HVCN1 INPP5B NME6 RP5-1115A15.1 VPS29
Myopia 1.39 1 0 0.0 0.00 1.0e+00 TMEM258
Vascular/heart problems diagnosed by doctor 1.74 13 2 6.1 0.53 5.0e-02 AC003029.1 ADAM1A ANKRD13B HECTD4 MADD NME6 PTPN12 RASIP1 RP5-1115A15.1 RTKN2 SUOX TMEM57 VPS29
Cholesterol lowering medication 1.34 2 0 0.0 0.00 1.0e+00 ANKRD13B RASIP1
Pain experienced in last month 1.17 2 0 0.0 0.00 1.0e+00 HECTD4 SUOX
Basal cell carcinoma (self-reported) 1.22 1 0 0.0 0.00 1.0e+00 TEF
Heart attack/myocardial infarction (self-reported) 1.38 1 0 0.0 0.00 1.0e+00 ANKRD13B
Impedance of whole body 1.06 12 8 24.2 -0.09 7.8e-01 ADAM1A BBS12 HECTD4 HVCN1 LRRC25 NEK6 PTK2 PTPN13 SUOX TEF UHRF1BP1 VPS29
Leg fat mass (left) 1.52 10 7 21.2 0.10 7.8e-01 ANKRD13B HECTD4 LRRC25 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 UHRF1BP1 VPS29
Arm predicted mass (left) 1.39 16 9 27.3 0.41 9.9e-02 AC003029.1 ADAM1A ALDH2 CD164 HECTD4 HVCN1 NEK6 PLEKHA1 PTPN12 PTPN13 RASIP1 SEPT2 SLC25A37 SUOX UHRF1BP1 VPS29

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 12 0.344 2.32
GTEx Adipose Visceral Omentum 10 0.491 2.23
GTEx Adrenal Gland 10 0.686 2.42
GTEx Artery Aorta 14 0.470 2.28
GTEx Artery Coronary 6 0.507 2.21
GTEx Artery Tibial 26 0.692 2.41
GTEx Brain Caudate basal ganglia 2 0.217 2.19
GTEx Brain Cerebellar Hemisphere 9 0.604 2.48
GTEx Brain Cerebellum 10 0.504 2.42
GTEx Brain Cortex 3 0.290 2.28
GTEx Brain Frontal Cortex BA9 7 0.757 2.54
GTEx Brain Hippocampus 1 0.190 2.17
GTEx Brain Hypothalamus 2 0.338 2.27
GTEx Brain Nucleus accumbens basal ganglia 3 0.346 2.27
GTEx Brain Putamen basal ganglia 3 0.481 2.64
GTEx Breast Mammary Tissue 9 0.456 2.37
GTEx Breast Mammary Tissue (Male) 7 0.587 2.20
GTEx Breast Mammary Tissue (Female) 12 0.729 2.37
GTEx Cells EBV-transformed lymphocytes 9 0.633 2.32
GTEx Cells Transformed fibroblasts 27 0.643 2.32
GTEx Colon Sigmoid 11 0.752 2.38
GTEx Colon Transverse 16 0.775 2.38
GTEx Esophagus Gastroesophageal Junction 10 0.692 2.44
GTEx Esophagus Mucosa 18 0.542 2.28
GTEx Esophagus Muscularis 19 0.588 2.27
GTEx Heart Atrial Appendage 5 0.316 2.16
GTEx Heart Left Ventricle 6 0.392 2.19
GTEx Liver 3 0.418 2.20
GTEx Lung 17 0.592 2.33
GTEx Muscle Skeletal 20 0.692 2.26
GTEx Nerve Tibial 31 0.717 2.37
GTEx Ovary 6 0.660 2.59
GTEx Pancreas 8 0.490 2.24
GTEx Pituitary 8 0.717 2.29
GTEx Prostate 4 0.480 2.27
GTEx Skin Not Sun Exposed Suprapubic 15 0.610 2.41
GTEx Skin Sun Exposed Lower leg 17 0.467 2.36
GTEx Small Intestine Terminal Ileum 5 1.082 2.26
GTEx Spleen 9 0.638 2.22
GTEx Stomach 11 0.756 2.52
GTEx Testis 19 0.602 2.38
GTEx Thyroid 31 0.776 2.47
GTEx Uterus 2 0.353 2.28
GTEx Vagina 2 0.315 2.31
GTEx Whole Blood 20 1.005 2.69
METSIM Adipose 30 0.651 2.27
NTR Blood 22 0.916 2.69
ROSMAP Brain Pre-frontal Cortex 19 0.433 2.16
YFS Blood 35 0.758 2.47
CommonMind Brain Pre-frontal Cortex 32 0.595 2.19
TCGA Breast Tumor 8 1.044 2.29
TCGA Breast Normal 21 0.499 2.18
TCGA Ovarian Tumor 10 0.342 2.03
TCGA Prostate Tumor 19 0.550 2.27