Hub : Traits :

Vascular/heart problems diagnosed by doctor

1003 significantly associated models · 303 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 2061969 1 1 2.4e-07 5.0e-06 5.1e-03 62 RP4-758J18.10
2 1 5829039 7221458 1 1 3.2e-07 3.8e-06 2.6e-02 77 TNFRSF25
3 1 7715776 9571422 2 1 1.9e-08 4.3e-08 2.5e-01 96 RP5-1115A15.1
4 1 10435170 12600396 5 3 1.7e-18 2.9e-26 2.5e-18 32 CLCN6 MTHFR RP4-635E18.7
5 1 20373107 21742737 1 1 2.8e-07 1.8e-07 3.9e-02 84 RP5-930J4.4
6 1 26428864 28406173 3 2 5.5e-08 3.7e-08 1.7e-04 53 CD164L2 PIGV
7 1 42542658 44549860 4 2 5.4e-08 6.2e-08 4.1e-02 86 MED8 RP5-994D16.9
8 1 88453303 90134392 3 1 2.8e-12 5.7e-12 9.0e-02 94 GTF2B
9 1 112312154 113941737 4 1 2.6e-11 4.1e-17 4.8e-14 20 WNT2B
10 1 115486678 116932921 1 1 2.3e-07 1.3e-12 5.9e-11 15 VANGL1
11 1 227217340 228663659 1 1 5.1e-08 3.4e-09 9.0e-05 56 SNAP47
12 1 230142626 231548480 1 1 4.0e-11 7.1e-11 1.9e-01 96 AGT
13 2 24021231 26068509 2 1 1.4e-08 1.2e-06 1.8e-03 59 EFR3B
14 2 36778887 38245716 1 1 4.5e-09 3.8e-08 1.0e+00 100 PRKD3
15 2 158621356 160236990 1 1 3.1e-07 2.6e-08 6.6e-04 62 PKP4
16 2 181042370 184084221 3 2 3.4e-09 1.4e-09 1.1e-02 82 PDE1A UBE2E3
17 2 218622292 220128895 1 1 1.9e-07 1.9e-04 1.4e-01 84 USP37
18 3 10617048 12293966 1 1 9.2e-08 1.3e-09 3.9e-03 77 ATG7
19 3 26563909 28211713 2 1 1.0e-19 1.6e-17 5.2e-05 78 SLC4A7
20 3 38812165 40267321 1 1 2.5e-07 1.0e-05 2.9e-03 54 MOBP
21 3 47204518 49365269 8 1 9.5e-12 7.9e-12 1.0e+00 100 FCF1P2
22 3 133088362 134666475 1 1 4.7e-08 5.4e-09 8.4e-03 80 RYK
23 3 135273949 136746974 1 1 1.5e-07 1.4e-09 1.7e-03 73 PCCB
24 3 137189600 139050702 5 1 1.7e-11 1.2e-11 1.5e-01 96 DBR1
25 3 157125828 158980014 2 1 1.7e-07 1.8e-06 3.4e-01 96 RP11-538P18.2
26 4 17104059 18507692 1 1 1.6e-09 7.5e-10 6.1e-03 80 DCAF16
27 4 25880334 27452482 1 1 1.2e-10 1.1e-14 8.3e-07 59 TBC1D19
28 4 37915462 39361551 2 1 8.0e-09 4.2e-08 3.2e-04 57 FLJ13197
29 4 80488345 82578407 2 1 7.9e-18 2.5e-58 1.8e-42 28 C4orf22
30 4 102852939 104627833 6 1 6.4e-12 1.2e-10 9.3e-01 100 CISD2
31 4 155890241 157354250 2 1 2.4e-09 1.1e-13 6.7e-13 7 RP11-588K22.2
32 5 113910679 115330276 1 1 2.1e-09 4.2e-11 5.4e-04 72 CCDC112
33 5 126596610 128116643 1 1 2.3e-07 5.8e-11 2.1e-05 58 CTC-228N24.3
34 5 130830617 132425049 7 1 9.1e-10 2.3e-09 7.4e-03 80 SLC22A4
35 5 147516165 148894875 1 1 1.9e-07 2.9e-10 9.5e-07 40 ADRB2
36 6 42586058 44034691 1 1 1.7e-10 8.7e-13 9.0e-04 78 ZNF318
37 6 57608708 58770624 1 1 1.8e-07 5.3e-07 8.7e-03 73 LINC00680
38 6 78880271 80486611 2 1 3.3e-09 1.2e-08 3.1e-01 97 PHIP
39 6 117078784 118613435 2 2 6.9e-08 1.3e-08 1.2e-08 0 DCBLD1 GOPC
40 6 126271503 128536730 2 2 1.0e-12 2.5e-28 1.4e-14 51 C6orf174 PRELID1P1
41 7 1787236 3264728 2 1 6.7e-11 1.5e-10 1.0e+00 100 LFNG
42 7 6502367 7988091 1 1 2.0e-14 7.8e-11 7.6e-02 93 C1GALT1
43 7 73425238 75255633 5 1 8.2e-09 1.6e-08 4.3e-02 87 STAG3L2
44 7 129342404 130779678 1 1 4.2e-09 5.6e-14 3.7e-13 7 CEP41
45 8 8092025 13120332 23 2 1.1e-13 1.5e-13 1.8e-03 82 MSRA NEIL2
46 8 25544268 26938804 1 1 1.1e-07 1.8e-14 1.7e-12 15 SDAD1P1
47 8 29996824 31433801 1 1 5.7e-09 9.8e-10 6.2e-02 91 TEX15
48 8 82017372 83452091 1 1 3.8e-08 4.8e-09 1.6e-02 83 SNX16
49 8 95213858 96825195 2 1 5.3e-09 2.7e-08 1.9e-01 94 NDUFAF6
50 8 102002608 103832256 2 1 3.5e-09 1.3e-09 6.6e-04 68 KB-1107E3.1
51 10 18221643 19601824 1 1 1.1e-07 1.9e-17 4.4e-15 15 NSUN6
52 10 21123825 22724472 1 1 3.4e-07 6.0e-07 9.7e-02 89 MLLT10
53 10 62473976 65606229 4 2 5.4e-12 6.4e-28 7.5e-26 8 NRBF2 TMEM26
54 10 95379543 96818402 1 1 2.6e-08 1.5e-10 5.8e-07 39 NOC3L
55 10 103313599 105850787 8 1 2.1e-15 1.2e-16 4.1e-03 88 NT5C2
56 10 115244596 116689519 1 1 5.2e-08 1.9e-19 7.3e-15 26 TDRD1
57 11 1213806 2705175 3 2 2.4e-16 3.8e-20 1.3e-04 83 TNNT3
58 11 9003306 10471931 1 1 6.2e-10 2.9e-12 2.3e-04 72 SWAP70
59 11 42881882 44596817 2 1 1.6e-08 9.2e-10 3.0e-03 76 HSD17B12
60 11 46010847 48783497 18 1 5.4e-21 1.8e-18 7.1e-07 68 ACP2
61 11 63305184 64701030 1 1 3.8e-07 1.6e-07 9.4e-02 90 VEGFB
62 11 64721908 66333072 2 1 1.6e-10 3.8e-12 2.5e-06 54 SIPA1
63 11 99859184 101559718 2 1 4.6e-36 1.4e-34 1.1e-01 98 TMEM133
64 11 106485489 108027561 2 1 2.4e-10 2.0e-11 5.9e-03 83 CWF19L2
65 11 110721187 112491227 5 1 2.4e-10 1.3e-10 1.0e+00 100 SIK2
66 12 47407397 49444545 3 2 1.4e-07 1.1e-07 1.2e-04 47 RP1-197B17.3 SENP1
67 12 49827409 51256065 2 1 5.8e-08 3.0e-10 2.2e-08 21 CERS5
68 12 57317393 58716588 1 1 3.8e-07 1.2e-05 3.4e-01 95 SLC26A10
69 12 69057879 70476863 1 1 4.7e-10 3.4e-09 2.7e-01 96 YEATS4
70 12 89116708 90799212 2 1 3.2e-13 2.9e-22 4.8e-14 40 ATP2B1
71 12 109591369 111015121 1 1 1.5e-07 1.3e-06 4.1e-01 97 GLTP
72 12 111102574 113517494 14 2 1.5e-21 7.2e-33 2.3e-08 78 ADAM1A SH2B3
73 12 121146219 123131824 3 3 6.8e-15 1.3e-14 1.0e+00 100 KDM2B RNF34 WDR66
74 13 29641514 31108727 1 1 1.6e-07 3.4e-08 5.5e-02 88 UBL3
75 14 103349176 104866687 2 1 1.3e-07 2.0e-07 4.1e-01 98 KLC1
76 15 40360741 42749023 8 1 5.4e-12 8.9e-12 1.7e-01 96 CHP1
77 15 67138238 68789191 1 1 1.0e-08 1.2e-08 2.4e-01 96 MAP2K5
78 15 73933444 76108550 12 9 3.7e-22 5.4e-22 NaN NaN ARID3B COX5A CSK CYP11A1 MPI RPP25 SCAMP2 ULK3
79 15 80377452 81936479 1 1 3.9e-13 7.8e-14 5.7e-02 94 KIAA1199
80 15 90712555 92187978 3 1 1.1e-36 3.7e-32 2.4e-01 99 FES
81 16 3025993 5441125 3 3 3.0e-11 1.1e-08 1.3e-05 42 AC006111.1 MGRN1
82 16 24162204 25620010 1 1 2.4e-07 2.0e-07 1.0e+00 100 SLC5A11
83 16 29711343 31860399 14 1 1.2e-10 8.9e-11 1.0e+00 100 VKORC1
84 16 89013848 90172696 7 1 3.6e-11 1.2e-11 5.5e-02 92 CDK10
85 17 3371501 4766937 1 1 9.3e-08 3.7e-07 4.6e-01 98 RP11-810M2.2
86 17 6754828 8484683 4 2 2.7e-09 3.4e-09 4.6e-01 98 LSMD1 SENP3
87 17 45921906 48139500 8 3 1.7e-10 1.8e-17 5.7e-12 34 HOXB2 RP11-463M16.4 ZNF652
88 17 60858059 62279811 1 1 4.3e-14 4.8e-15 1.0e+00 100 ACE
89 17 73220999 74629867 1 1 3.1e-07 3.0e-07 1.9e-01 93 FBF1
90 17 78665405 80023050 1 1 1.2e-07 1.7e-05 3.9e-04 32 RP11-1055B8.4
91 19 1163934 2560423 2 2 6.2e-08 2.0e-08 1.0e+00 100 CTB-31O20.6 KLF16
92 19 3309021 4732167 1 1 3.8e-07 2.2e-06 7.3e-02 86 PIAS4
93 19 7793502 9200017 1 1 1.9e-07 1.3e-06 6.8e-01 99 MARCH2
94 19 16045294 18180451 5 3 5.9e-13 3.1e-14 1.0e+00 100 CTC-429P9.1 CTD-3032J10.3 MYO9B
95 20 7419920 9648826 1 1 1.9e-08 2.5e-18 2.0e-11 41 PLCB1
96 20 29927166 31615615 3 2 3.4e-09 1.1e-09 1.9e-07 27 C20orf160 TSPY26P
97 20 56858751 58262841 1 1 4.2e-08 1.4e-34 3.5e-29 16 NELFCD
98 20 61522825 62912463 7 5 5.7e-14 2.2e-12 1.0e+00 100 GMEB2 OPRL1 RGS19 TCEA2 ZBTB46
99 21 44251223 45879403 3 1 1.6e-09 2.4e-10 2.1e-02 87 PDXK
100 22 28792887 30261219 1 1 4.1e-07 1.7e-06 4.0e-02 82 KREMEN1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.56 3 1 3.0 0.00 1.0e+00 ACE PRKD3 VKORC1
Crohns Disease (2017) 1.35 2 1 3.0 0.00 1.0e+00 SLC22A4 STAG3L2
Irritable Bowel Disease (IBD) 1.45 5 1 3.0 0.80 1.0e-01 GMEB2 OPRL1 RGS19 SLC22A4 STAG3L2
Ulcerative Colitis (UC) 1.37 2 1 3.0 0.00 1.0e+00 OPRL1 RGS19
Major Depression (MDD) 1.16 2 0 0.0 0.00 1.0e+00 FES NT5C2
Reaction Time 1.41 2 1 3.0 0.00 1.0e+00 PIAS4 SH2B3
Verbal and Numeric Reasoning (VNR) 1.13 3 1 3.0 0.00 1.0e+00 DCAF16 SLC5A11 TEX15
Breast Cancer 2.52 9 4 12.1 0.19 6.3e-01 CSK FES MLLT10 RGS19 RP11-1055B8.4 SIK2 SIPA1 SLC4A7 TNNT3
Ovarian Cancer 1.28 2 1 3.0 0.00 1.0e+00 HOXB2 MLLT10
Prostate Cancer 1.62 1 0 0.0 0.00 1.0e+00 TNNT3
Body Mass Index (BMI) (2010) 1.67 1 1 3.0 0.00 1.0e+00 MAP2K5
Coronary Artery Disease (CAD) 2.17 4 2 6.1 0.96 4.4e-02 DBR1 NT5C2 RP11-463M16.4 SH2B3
Crohns Disease (2012) 1.19 1 1 3.0 0.00 1.0e+00 SLC22A4
Fasting Glucose 1.70 1 1 3.0 0.00 1.0e+00 ACP2
HbA1C 1.19 1 0 0.0 0.00 1.0e+00 ADAM1A
HDL Cholesterol 1.66 3 1 3.0 0.00 1.0e+00 ACP2 PIGV SIPA1
LDL Cholesterol 1.49 2 0 0.0 0.00 1.0e+00 PIGV SH2B3
Lupus 1.64 1 0 0.0 0.00 1.0e+00 MSRA
Neuroticism 1.43 2 1 3.0 0.00 1.0e+00 MSRA NEIL2
Primary Biliary Cirrhosis 1.26 2 1 3.0 0.00 1.0e+00 CISD2 SH2B3
Rheumatoid Arthritis 1.28 1 0 0.0 0.00 1.0e+00 SH2B3
Schizophrenia 1.78 8 4 12.1 0.05 9.0e-01 CERS5 CISD2 FES KLC1 MSRA NT5C2 PCCB RP5-1115A15.1
Triglycerides 1.56 4 0 0.0 0.02 9.8e-01 MSRA NEIL2 NRBF2 VKORC1
Type 2 Diabetes (T2D) 1.83 2 0 0.0 0.00 1.0e+00 HOXB2 HSD17B12
Ulcerative Colitis 1.22 1 0 0.0 0.00 1.0e+00 SLC26A10
Blood Eosinophil Count 4.09 18 13 39.4 0.76 2.3e-04 ADAM1A ADRB2 CD164L2 CERS5 FBF1 FLJ13197 GLTP KLC1 NDUFAF6 PDXK PIGV RP5-1115A15.1 SH2B3 SIK2 SLC22A4 TSPY26P VKORC1 ZNF652
Blood Platelet Count 2.81 39 25 75.8 0.03 8.4e-01 ADAM1A C20orf160 CDK10 CERS5 COX5A CSK CWF19L2 DCAF16 FBF1 FLJ13197 GMEB2 GTF2B KREMEN1 LFNG MGRN1 MPI MYO9B NELFCD NRBF2 PCCB PHIP PIGV RP11-463M16.4 RPP25 SCAMP2 SENP1 SH2B3 SIK2 SIPA1 SLC22A4 SLC26A10 SLC4A7 SNX16 SWAP70 TMEM26 TNNT3 USP37 WNT2B ZNF318
Blood Red Count 2.12 38 30 90.9 0.54 3.4e-04 ADAM1A ARID3B C20orf160 C4orf22 C6orf174 CDK10 CLCN6 COX5A CSK CYP11A1 FBF1 FLJ13197 GMEB2 GTF2B KLC1 LSMD1 MAP2K5 MED8 MGRN1 MPI NDUFAF6 NELFCD NT5C2 PDXK PIAS4 RP5-930J4.4 RPP25 SCAMP2 SENP1 SH2B3 SIPA1 TDRD1 TSPY26P UBE2E3 ULK3 USP37 VEGFB VKORC1
Blood White Count 2.33 27 17 51.5 0.51 7.2e-03 ADAM1A ADRB2 CDK10 CERS5 CTC-429P9.1 DCAF16 EFR3B FES FLJ13197 GTF2B KB-1107E3.1 KLC1 LSMD1 MGRN1 MOBP NRBF2 NT5C2 PCCB RP5-1115A15.1 SH2B3 SLC22A4 SLC5A11 TEX15 TMEM133 UBE2E3 VEGFB VKORC1
Heel T-Score 2.24 28 21 63.6 -0.17 3.7e-01 ACP2 ATG7 C20orf160 C6orf174 DCAF16 FLJ13197 GTF2B KLC1 KREMEN1 LFNG LSMD1 MARCH2 NELFCD NT5C2 PDE1A RP11-810M2.2 RP4-635E18.7 RP5-1115A15.1 SENP3 SIPA1 SLC5A11 SNAP47 STAG3L2 TMEM133 TNFRSF25 UBE2E3 VKORC1 ZNF318
BMI 2.42 40 24 72.7 0.58 9.0e-05 AC006111.1 C20orf160 C4orf22 CEP41 CHP1 CISD2 CLCN6 COX5A CTB-31O20.6 FBF1 FLJ13197 HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLC1 KLF16 MAP2K5 MLLT10 NRBF2 NT5C2 PCCB PIAS4 RNF34 RP11-463M16.4 RP11-538P18.2 RP4-758J18.10 RP5-1115A15.1 RPP25 SCAMP2 SIPA1 SLC5A11 STAG3L2 TDRD1 TEX15 TNFRSF25 TSPY26P USP37 VKORC1 ZNF318
Height 1.92 50 42 127.3 -0.40 3.8e-03 AC006111.1 ACE ACP2 C20orf160 CCDC112 CERS5 CHP1 CTC-228N24.3 CYP11A1 DBR1 DCAF16 EFR3B FES GOPC GTF2B HOXB2 KLC1 MARCH2 MED8 MGRN1 PDE1A PIAS4 PIGV PRELID1P1 RP11-1055B8.4 RP11-463M16.4 RP11-538P18.2 RP11-810M2.2 RP4-635E18.7 RP5-1115A15.1 RP5-930J4.4 RP5-994D16.9 RYK SDAD1P1 SENP3 SH2B3 SIPA1 SLC22A4 SLC26A10 SLC4A7 SLC5A11 SNAP47 TMEM133 TNNT3 USP37 WDR66 WNT2B YEATS4 ZNF318 ZNF652
Waist Hip Ratio (WHR) 2.15 23 13 39.4 0.53 9.2e-03 ADAM1A C6orf174 CEP41 CTD-3032J10.3 CYP11A1 DBR1 GTF2B KREMEN1 MYO9B OPRL1 PCCB PRELID1P1 RGS19 RP11-810M2.2 RP5-930J4.4 SIK2 SIPA1 SNAP47 SWAP70 TBC1D19 TCEA2 VEGFB ZNF318
Systolic Blood Pressure 11.86 105 87 263.6 0.97 1.0e-63 AC006111.1 ACE ACP2 ADAM1A ADRB2 AGT ARID3B ATG7 ATP2B1 C1GALT1 C20orf160 C4orf22 C6orf174 CCDC112 CD164L2 CERS5 CHP1 CLCN6 COX5A CSK CTB-31O20.6 CTC-228N24.3 CTC-429P9.1 CTD-3032J10.3 CWF19L2 CYP11A1 DBR1 DCAF16 DCBLD1 EFR3B FBF1 FCF1P2 FES FLJ13197 GLTP GMEB2 GOPC GTF2B HOXB2 KB-1107E3.1 KDM2B KIAA1199 KLF16 KREMEN1 LFNG LSMD1 MED8 MGRN1 MPI MTHFR MYO9B NDUFAF6 NEIL2 NELFCD NOC3L NRBF2 NSUN6 NT5C2 OPRL1 PDE1A PDXK PHIP PIGV PLCB1 PRELID1P1 PRKD3 RGS19 RNF34 RP11-1055B8.4 RP11-463M16.4 RP11-538P18.2 RP11-588K22.2 RP4-635E18.7 RP4-758J18.10 RP5-1115A15.1 RP5-930J4.4 RPP25 RYK SCAMP2 SDAD1P1 SENP1 SENP3 SH2B3 SIK2 SIPA1 SLC26A10 SLC4A7 SLC5A11 SNAP47 SNX16 STAG3L2 SWAP70 TBC1D19 TCEA2 TMEM133 TMEM26 TNFRSF25 TNNT3 UBL3 ULK3 VEGFB WDR66 WNT2B ZBTB46 ZNF318
Smoking Status 1.55 11 1 3.0 0.47 1.4e-01 ADAM1A FES KIAA1199 KLC1 MAP2K5 MED8 MLLT10 RP11-463M16.4 RP5-1115A15.1 SLC5A11 ZNF652
Allergy or Eczema 1.92 9 4 12.1 0.33 3.9e-01 ADAM1A CHP1 GMEB2 NRBF2 RNF34 RP5-1115A15.1 SIK2 SLC22A4 ULK3
Cardiovascular Disease 12.82 123 103 312.1 0.99 3.9e-109 AC006111.1 ACE ACP2 ADAM1A ADRB2 AGT ARID3B ATG7 ATP2B1 C1GALT1 C20orf160 C4orf22 C6orf174 CCDC112 CD164L2 CDK10 CEP41 CERS5 CHP1 CISD2 CLCN6 COX5A CSK CTB-31O20.6 CTC-228N24.3 CTC-429P9.1 CTD-3032J10.3 CWF19L2 CYP11A1 DBR1 DCAF16 DCBLD1 EFR3B FBF1 FCF1P2 FES FLJ13197 GLTP GMEB2 GOPC GTF2B HOXB2 HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLC1 KLF16 KREMEN1 LFNG LSMD1 MAP2K5 MARCH2 MED8 MGRN1 MLLT10 MOBP MPI MTHFR MYO9B NDUFAF6 NELFCD NOC3L NRBF2 NSUN6 NT5C2 OPRL1 PCCB PDE1A PDXK PHIP PIGV PLCB1 PRELID1P1 RGS19 RNF34 RP11-1055B8.4 RP11-463M16.4 RP11-538P18.2 RP11-588K22.2 RP11-810M2.2 RP4-635E18.7 RP4-758J18.10 RP5-1115A15.1 RP5-930J4.4 RP5-994D16.9 RPP25 RYK SCAMP2 SDAD1P1 SENP1 SENP3 SH2B3 SIK2 SIPA1 SLC26A10 SLC4A7 SNAP47 SNX16 STAG3L2 SWAP70 TBC1D19 TCEA2 TDRD1 TEX15 TMEM133 TMEM26 TNFRSF25 TNNT3 TSPY26P UBE2E3 UBL3 ULK3 USP37 VANGL1 VEGFB VKORC1 WDR66 WNT2B YEATS4 ZBTB46 ZNF318 ZNF652
Hypothyroidism (self reported) 2.14 3 3 9.1 0.00 1.0e+00 ADAM1A RP5-1115A15.1 SH2B3
Respiratory disease 1.70 6 2 6.1 0.68 1.4e-01 CHP1 GMEB2 RP5-1115A15.1 SIK2 SLC22A4 ZNF652
Type 2 Diabetes (T2D) 2.34 9 3 9.1 0.75 2.0e-02 ACE ADAM1A DBR1 NDUFAF6 PRELID1P1 SH2B3 SIPA1 VEGFB ZBTB46
Lung FEV1/FVC ratio 1.42 18 13 39.4 -0.33 1.8e-01 ATG7 ATP2B1 C1GALT1 CEP41 CTB-31O20.6 GOPC KB-1107E3.1 MARCH2 MLLT10 NRBF2 RP11-810M2.2 RP5-1115A15.1 SLC22A4 SLC5A11 TMEM133 TNFRSF25 TSPY26P ZNF652
Lung FVC 1.66 20 13 39.4 -0.46 4.0e-02 C1GALT1 CHP1 CTC-228N24.3 CTD-3032J10.3 DBR1 DCAF16 GMEB2 HOXB2 HSD17B12 MAP2K5 MLLT10 NRBF2 OPRL1 RP11-538P18.2 SH2B3 SLC22A4 TCEA2 TNFRSF25 VKORC1 ZBTB46
Neuroticism 1.10 5 2 6.1 0.39 5.2e-01 ACP2 MAP2K5 NT5C2 PCCB RP5-1115A15.1
Chronotype (morning person) 1.26 3 0 0.0 0.00 1.0e+00 RP11-810M2.2 RP5-1115A15.1 RP5-930J4.4
Hair Pigment 3.78 17 10 30.3 0.24 3.6e-01 ACP2 ATP2B1 C20orf160 C4orf22 CDK10 DBR1 FES FLJ13197 HOXB2 KLC1 PIGV RGS19 RP5-1115A15.1 SH2B3 SIPA1 SNX16 TSPY26P
Tanning 4.17 5 3 9.1 -0.57 3.1e-01 CDK10 NRBF2 SH2B3 TSPY26P ULK3
Hand grip strength (left) 1.58 7 3 9.1 0.47 2.9e-01 DCAF16 FES HOXB2 MGRN1 SLC22A4 SLC5A11 SNAP47
Number of treatments/medications taken 4.27 15 6 18.2 -0.97 4.7e-09 ACE ADAM1A CHP1 CISD2 DCAF16 FLJ13197 KIAA1199 MLLT10 MOBP PIAS4 SH2B3 SLC22A4 STAG3L2 TMEM133 YEATS4
Sensitivity / hurt feelings 1.08 2 0 0.0 0.00 1.0e+00 FES MSRA
Frequency of depressed mood in last 2 weeks 1.15 1 0 0.0 0.00 1.0e+00 RP5-1115A15.1
Hearing difficulty/problems: Yes 1.21 1 1 3.0 0.00 1.0e+00 ZNF318
Relative age of first facial hair 1.17 2 2 6.1 0.00 1.0e+00 ATG7 C4orf22
Ever had hysterectomy (womb removed) 1.19 1 0 0.0 0.00 1.0e+00 MLLT10
Systolic blood pressure, automated reading 8.78 65 44 133.3 -0.98 1.0e-47 AC006111.1 ACP2 ADRB2 AGT ATG7 ATP2B1 C4orf22 C6orf174 CERS5 CHP1 CLCN6 COX5A CSK CTB-31O20.6 CTC-228N24.3 CWF19L2 DCAF16 DCBLD1 FCF1P2 FES FLJ13197 GLTP GMEB2 GOPC GTF2B HOXB2 KIAA1199 KLF16 LFNG MED8 MGRN1 MPI MSRA MTHFR MYO9B NEIL2 NELFCD NOC3L NRBF2 NSUN6 NT5C2 OPRL1 PHIP PIGV PRELID1P1 PRKD3 RGS19 RP11-538P18.2 RP11-588K22.2 RP4-635E18.7 RP5-1115A15.1 RPP25 SENP3 SH2B3 SIPA1 SLC4A7 SLC5A11 STAG3L2 SWAP70 TCEA2 TMEM133 TNNT3 ULK3 WNT2B ZBTB46
Angina 3.01 5 1 3.0 -0.99 1.0e-03 FES OPRL1 RGS19 RP11-463M16.4 TCEA2
Medication: Metformin 1.81 2 0 0.0 0.00 1.0e+00 CISD2 DBR1
Pack years adult smoking proportion 1.35 1 0 0.0 0.00 1.0e+00 PIAS4
Impedance of leg (right) 2.25 32 18 54.5 -0.07 7.0e-01 ATG7 CEP41 CERS5 CTB-31O20.6 CTC-228N24.3 CTD-3032J10.3 FES HSD17B12 KIAA1199 KLF16 MAP2K5 MSRA MYO9B NEIL2 NELFCD NOC3L NT5C2 PRKD3 RP11-463M16.4 RP4-758J18.10 RYK SENP1 SENP3 SNAP47 STAG3L2 SWAP70 TMEM133 USP37 VKORC1 WDR66 ZNF318 ZNF652
Leg fat-free mass (left) 1.86 22 12 36.4 0.20 3.8e-01 CTB-31O20.6 CTC-228N24.3 DCAF16 FES HSD17B12 KIAA1199 KLF16 MAP2K5 MLLT10 MSRA MYO9B NEIL2 NT5C2 PDE1A PRELID1P1 SH2B3 SLC22A4 SLC5A11 TDRD1 ULK3 VKORC1 WDR66
Trunk fat percentage 2.14 25 9 27.3 -0.65 4.3e-04 CDK10 CHP1 CLCN6 COX5A CTB-31O20.6 CTD-3032J10.3 DBR1 HSD17B12 KDM2B KLC1 MAP2K5 MLLT10 MSRA MYO9B NOC3L PIAS4 RNF34 RP11-810M2.2 RP5-1115A15.1 SENP3 SLC5A11 STAG3L2 TEX15 TNFRSF25 VKORC1
Hand grip strength (right) 1.64 7 4 12.1 0.37 4.1e-01 DCAF16 HOXB2 MLLT10 SLC22A4 SLC5A11 SNAP47 WNT2B
Townsend deprivation index at recruitment 1.30 2 0 0.0 0.00 1.0e+00 KLF16 MAP2K5
Current tobacco smoking 1.53 2 0 0.0 0.00 1.0e+00 MSRA SLC5A11
Average weekly fortified wine intake 0.96 1 0 0.0 0.00 1.0e+00 SLC5A11
Maternal smoking around birth 1.59 5 0 0.0 -0.67 2.1e-01 C20orf160 KLC1 MED8 MLLT10 SLC5A11
Fed-up feelings 1.27 3 2 6.1 0.00 1.0e+00 MSRA SH2B3 TEX15
Frequency of unenthusiasm / disinterest in last 2 weeks 1.34 1 0 0.0 0.00 1.0e+00 RP5-930J4.4
Relative age voice broke 1.13 1 0 0.0 0.00 1.0e+00 STAG3L2
Taking other prescription medications 2.43 6 1 3.0 -0.99 5.4e-05 ADAM1A CHP1 CISD2 SH2B3 STAG3L2 ZNF318
Age when periods started (menarche) 1.58 7 5 15.2 0.47 2.9e-01 CTB-31O20.6 HSD17B12 KLF16 MAP2K5 MED8 SIPA1 STAG3L2
Bilateral oophorectomy (both ovaries removed) 1.23 1 0 0.0 0.00 1.0e+00 MLLT10
Heel bone mineral density (BMD) T-score, automated (left) 2.05 9 5 15.2 0.10 7.9e-01 ACP2 C6orf174 KLC1 KREMEN1 LSMD1 MSRA NEIL2 RP5-1115A15.1 SIPA1
High blood pressure 14.06 132 106 321.2 -1.00 5.3e-153 AC006111.1 ACE ACP2 ADAM1A ADRB2 AGT ARID3B ATG7 ATP2B1 C1GALT1 C20orf160 C4orf22 C6orf174 CCDC112 CD164L2 CDK10 CEP41 CERS5 CHP1 CISD2 CLCN6 COX5A CSK CTB-31O20.6 CTC-228N24.3 CTC-429P9.1 CTD-3032J10.3 CWF19L2 CYP11A1 DBR1 DCAF16 DCBLD1 EFR3B FBF1 FCF1P2 FES FLJ13197 GLTP GMEB2 GOPC GTF2B HOXB2 HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLC1 KLF16 KREMEN1 LFNG LINC00680 LSMD1 MAP2K5 MARCH2 MED8 MGRN1 MLLT10 MOBP MPI MSRA MTHFR MYO9B NDUFAF6 NEIL2 NELFCD NOC3L NRBF2 NSUN6 NT5C2 OPRL1 PCCB PDE1A PDXK PHIP PIAS4 PIGV PKP4 PLCB1 PRELID1P1 PRKD3 RGS19 RNF34 RP11-1055B8.4 RP11-463M16.4 RP11-538P18.2 RP11-588K22.2 RP11-810M2.2 RP1-197B17.3 RP4-635E18.7 RP4-758J18.10 RP5-1115A15.1 RP5-930J4.4 RP5-994D16.9 RPP25 RYK SCAMP2 SDAD1P1 SENP1 SENP3 SH2B3 SIK2 SIPA1 SLC22A4 SLC26A10 SLC4A7 SLC5A11 SNAP47 SNX16 STAG3L2 SWAP70 TBC1D19 TCEA2 TDRD1 TEX15 TMEM133 TMEM26 TNFRSF25 TNNT3 TSPY26P UBE2E3 UBL3 ULK3 USP37 VANGL1 VEGFB VKORC1 WDR66 WNT2B YEATS4 ZBTB46 ZNF318 ZNF652
Hayfever, allergic rhinitis or eczema 1.94 5 4 12.1 -0.40 5.0e-01 ADAM1A CHP1 RP5-1115A15.1 SIK2 SLC22A4
Supplements: Glucosamine 1.68 2 1 3.0 0.00 1.0e+00 CSK NRBF2
Medication: Atenolol 5.10 4 2 6.1 -0.99 1.1e-02 FES PRKD3 SH2B3 TMEM133
Medication: Levothyroxine sodium 1.98 3 2 6.1 0.00 1.0e+00 ADAM1A MSRA SH2B3
Sitting height 1.57 19 12 36.4 0.31 2.0e-01 C20orf160 CERS5 CHP1 DCAF16 DCBLD1 GOPC GTF2B KIAA1199 KLC1 MARCH2 MLLT10 PRELID1P1 RP11-463M16.4 RP11-538P18.2 SLC22A4 SLC26A10 SLC4A7 SNAP47 WDR66
High blood pressure (mother) 5.18 11 3 9.1 -0.98 3.0e-07 AGT C4orf22 C6orf174 CLCN6 FES NT5C2 PIGV SENP1 SLC4A7 TNFRSF25 TNNT3
Body mass index (BMI) 2.54 29 15 45.5 -0.61 4.9e-04 CEP41 CLCN6 COX5A CTB-31O20.6 CYP11A1 GTF2B HSD17B12 KDM2B KIAA1199 KLC1 KLF16 MAP2K5 MLLT10 MSRA NEIL2 NRBF2 PIAS4 RP5-1115A15.1 RPP25 SCAMP2 SIPA1 SLC5A11 STAG3L2 TDRD1 TEX15 TNFRSF25 ULK3 USP37 VKORC1
Impedance of leg (left) 2.24 28 19 57.6 -0.01 9.6e-01 ATG7 CEP41 CERS5 CTB-31O20.6 CTC-228N24.3 CTD-3032J10.3 FES HSD17B12 KIAA1199 KLF16 MAP2K5 MSRA MYO9B NEIL2 NELFCD NOC3L NT5C2 PRKD3 RP11-463M16.4 RP4-758J18.10 SNAP47 STAG3L2 SWAP70 TMEM133 USP37 VKORC1 ZNF318 ZNF652
Leg predicted mass (left) 1.86 21 12 36.4 0.17 4.7e-01 CTB-31O20.6 CTC-228N24.3 DCAF16 FES HSD17B12 KIAA1199 KLF16 MAP2K5 MLLT10 MSRA MYO9B NEIL2 NT5C2 PDE1A PRELID1P1 SLC22A4 SLC5A11 TDRD1 ULK3 VKORC1 WDR66
Trunk fat mass 2.04 24 8 24.2 -0.63 8.9e-04 CLCN6 COX5A CTB-31O20.6 DBR1 EFR3B HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLF16 MAP2K5 MLLT10 MSRA PIAS4 RNF34 RP11-810M2.2 RP5-1115A15.1 RPP25 SLC5A11 STAG3L2 TDRD1 TEX15 TNFRSF25 VKORC1
Waist circumference 2.45 28 13 39.4 -0.49 8.3e-03 COX5A CSK CTB-31O20.6 CYP11A1 EFR3B HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLF16 MAP2K5 MLLT10 MPI NRBF2 PCCB PHIP PIAS4 RP11-810M2.2 RPP25 SCAMP2 SIPA1 SLC5A11 STAG3L2 TDRD1 TEX15 TNFRSF25 ULK3 VKORC1
Number of incorrect matches in round 1.17 1 1 3.0 0.00 1.0e+00 VKORC1
Past tobacco smoking 1.60 4 1 3.0 0.95 5.1e-02 ADAM1A MAP2K5 MLLT10 SH2B3
Nervous feelings 1.39 3 2 6.1 0.00 1.0e+00 MSRA NEIL2 PCCB
Frequency of tenseness / restlessness in last 2 weeks 1.06 1 0 0.0 0.00 1.0e+00 PCCB
Hearing difficulty/problems with background noise 1.53 4 2 6.1 0.47 5.3e-01 CSK KLC1 ULK3 ZNF318
Hair/balding pattern: Pattern 2 1.23 1 1 3.0 0.00 1.0e+00 C4orf22
Had menopause 1.00 1 0 0.0 0.00 1.0e+00 CHP1
Forced vital capacity (FVC) 1.84 12 6 18.2 0.69 1.2e-02 ACP2 CTC-228N24.3 DCAF16 GMEB2 HOXB2 MLLT10 PIAS4 RP11-538P18.2 SNAP47 VKORC1 WDR66 WNT2B
Heel bone mineral density (BMD) T-score, automated (right) 2.05 8 5 15.2 0.17 6.9e-01 ACP2 C6orf174 DCAF16 KREMEN1 LSMD1 MSRA NEIL2 RP5-1115A15.1
Qualifications: None of the above 1.39 2 0 0.0 0.00 1.0e+00 PHIP SLC5A11
Financial difficulties in last 2 years 1.70 1 0 0.0 0.00 1.0e+00 VKORC1
Mouth/teeth dental problems 1.64 2 0 0.0 0.00 1.0e+00 KLC1 SIPA1
Heart attack 2.78 1 1 3.0 0.00 1.0e+00 FES
Allergy 1.93 8 5 15.2 0.13 7.6e-01 ADAM1A CHP1 FES GMEB2 RP5-1115A15.1 SIK2 SLC22A4 ZNF652
Diabetes (self-reported) 2.13 2 0 0.0 0.00 1.0e+00 STAG3L2 ZBTB46
Medication: Ramipril 4.97 7 2 6.1 -0.96 4.4e-04 ADAM1A CISD2 CSK CYP11A1 FES GOPC TMEM133
Medication: Simvastatin 4.15 9 3 9.1 -0.93 2.2e-04 FES OPRL1 PIGV RGS19 SIPA1 TCEA2 TMEM133 VEGFB YEATS4
Fluid intelligence score 1.24 1 1 3.0 0.00 1.0e+00 DCAF16
Illnesses of siblings 3.90 10 0 0.0 0.95 1.8e-05 ADAM1A CLCN6 FES FLJ13197 NRBF2 PRELID1P1 SH2B3 SLC5A11 TMEM133 VKORC1
Neuroticism score 1.28 4 2 6.1 1.00 1.4e-03 MSRA NEIL2 PCCB RP5-1115A15.1
Weight 1.97 24 15 45.5 -0.27 2.0e-01 CLCN6 CTB-31O20.6 DCAF16 EFR3B FLJ13197 HSD17B12 KB-1107E3.1 KIAA1199 KLF16 MAP2K5 MLLT10 MSRA NEIL2 RP11-810M2.2 RPP25 SCAMP2 SH2B3 SLC22A4 SLC5A11 STAG3L2 TDRD1 ULK3 VKORC1 WDR66
Impedance of arm (right) 2.10 32 13 39.4 0.26 1.6e-01 CEP41 CERS5 CISD2 CTB-31O20.6 CTD-3032J10.3 CYP11A1 HSD17B12 KIAA1199 KLF16 KREMEN1 MAP2K5 MARCH2 MLLT10 MSRA MYO9B NEIL2 NOC3L NRBF2 PDE1A PRKD3 RP11-463M16.4 RYK SENP1 SENP3 SLC4A7 SNX16 SWAP70 TNNT3 TSPY26P ULK3 VKORC1 ZNF652
Arm fat percentage (right) 2.30 25 14 42.4 -0.76 1.3e-05 CHP1 CLCN6 COX5A CTB-31O20.6 DCAF16 FBF1 HSD17B12 KDM2B KLC1 KLF16 MAP2K5 MLLT10 MSRA PIAS4 RNF34 RP11-810M2.2 RP5-1115A15.1 SENP3 SIPA1 SLC5A11 STAG3L2 TDRD1 TEX15 TNFRSF25 VKORC1
Trunk fat-free mass 1.87 20 12 36.4 0.24 3.1e-01 CCDC112 CTD-3032J10.3 DCAF16 EFR3B HSD17B12 KIAA1199 KLF16 MARCH2 MYO9B PDE1A PRELID1P1 SENP3 SH2B3 SLC22A4 SLC4A7 SLC5A11 TMEM133 ULK3 VKORC1 WDR66
Hip circumference 2.02 19 10 30.3 -0.39 9.8e-02 CCDC112 CLCN6 CTB-31O20.6 DCAF16 HSD17B12 KB-1107E3.1 KIAA1199 KLF16 MAP2K5 MLLT10 MSRA PHIP RP11-810M2.2 SH2B3 SLC5A11 STAG3L2 VEGFB VKORC1 WDR66
Alcohol intake versus 10 years previously 1.18 1 0 0.0 0.00 1.0e+00 PDXK
Father's age at death 2.31 3 2 6.1 0.00 1.0e+00 FES SH2B3 SLC22A4
Worrier / anxious feelings 1.70 3 1 3.0 0.00 1.0e+00 MSRA NEIL2 PCCB
Frequency of tiredness / lethargy in last 2 weeks 1.39 1 0 0.0 0.00 1.0e+00 RP5-1115A15.1
Hair/balding pattern: Pattern 3 1.38 1 1 3.0 0.00 1.0e+00 C4orf22
Forced expiratory volume in 1-second (FEV1) 1.84 12 3 9.1 0.00 1.0e+00 DCAF16 GOPC HOXB2 MSRA NRBF2 PIAS4 RP11-538P18.2 SNAP47 TMEM133 TSPY26P UBE2E3 VKORC1
Qualifications: A levels/AS levels or equivalent 1.34 2 0 0.0 0.00 1.0e+00 DCAF16 MSRA
Mouth/teeth dental problems: Dentures 1.31 2 0 0.0 0.00 1.0e+00 MSRA RP11-1055B8.4
Asthma 1.67 5 4 12.1 -0.59 2.9e-01 MLLT10 RP5-1115A15.1 SIK2 SLC22A4 ZNF652
Medication: Cholesterol lowering 4.22 10 4 12.1 -0.97 2.2e-06 CHP1 FES OPRL1 PIGV RGS19 SIPA1 TCEA2 TMEM133 TNFRSF25 YEATS4
Depression (self-reported) 1.14 1 1 3.0 0.00 1.0e+00 RP5-1115A15.1
Illnesses of mother 3.49 2 1 3.0 0.00 1.0e+00 AGT FES
Forced expiratory volume in 1-second (FEV1), Best measure 1.84 8 4 12.1 0.06 8.8e-01 DCAF16 MSRA NRBF2 PIAS4 RP11-538P18.2 SNAP47 TMEM133 VKORC1
Pulse wave Arterial Stiffness index 1.90 2 1 3.0 0.00 1.0e+00 ADAM1A VEGFB
Impedance of arm (left) 2.06 29 12 36.4 0.19 3.2e-01 CERS5 CISD2 CTD-3032J10.3 CYP11A1 HSD17B12 KIAA1199 KLF16 KREMEN1 MAP2K5 MARCH2 MLLT10 MSRA MYO9B NEIL2 NOC3L NRBF2 PDE1A PRKD3 RP11-463M16.4 RYK SENP1 SENP3 SH2B3 SLC4A7 TNNT3 TSPY26P ULK3 VKORC1 ZNF652
Arm fat mass (right) 2.22 25 9 27.3 -0.66 3.1e-04 CLCN6 COX5A CTB-31O20.6 EFR3B HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLC1 KLF16 MAP2K5 MLLT10 MSRA PIAS4 RP11-810M2.2 RP5-1115A15.1 RPP25 SIPA1 SLC5A11 STAG3L2 TDRD1 TEX15 TNFRSF25 ULK3 VKORC1
Trunk predicted mass 1.88 19 12 36.4 0.27 2.7e-01 CCDC112 CTD-3032J10.3 DCAF16 EFR3B HSD17B12 KIAA1199 KLF16 MARCH2 MYO9B PDE1A PRELID1P1 SENP3 SH2B3 SLC22A4 SLC4A7 SLC5A11 TMEM133 ULK3 WDR66
Standing height 1.86 35 20 60.6 0.45 6.3e-03 AC006111.1 ACP2 CERS5 CHP1 DCAF16 EFR3B GOPC GTF2B HOXB2 KLC1 MARCH2 MED8 MGRN1 MSRA PDE1A PIAS4 PIGV PRELID1P1 RP11-1055B8.4 RP11-463M16.4 RP11-538P18.2 RP11-810M2.2 RP4-635E18.7 RP5-1115A15.1 RP5-930J4.4 RYK SH2B3 SIPA1 SLC22A4 SLC5A11 SNAP47 USP37 WDR66 YEATS4 ZNF318
Breastfed as a baby 1.06 1 0 0.0 0.00 1.0e+00 RP4-758J18.10
Tense / 'highly strung' 1.39 4 1 3.0 0.55 4.5e-01 MSRA NT5C2 PCCB RP5-1115A15.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.28 1 0 0.0 0.00 1.0e+00 RP5-1115A15.1
Hair/balding pattern: Pattern 4 1.54 4 1 3.0 -0.66 3.4e-01 C4orf22 CERS5 PRELID1P1 RP5-1115A15.1
Birth weight of first child 2.67 12 3 9.1 0.99 2.9e-09 CLCN6 COX5A CSK CTC-228N24.3 DCAF16 FES GTF2B MPI MTHFR OPRL1 RPP25 SH2B3
Peak expiratory flow (PEF) 1.59 4 2 6.1 0.99 1.3e-02 C1GALT1 DCAF16 MSRA PIAS4
Medication: Paracetamol 1.56 1 0 0.0 0.00 1.0e+00 MLLT10
Headache pain in last month 1.21 1 0 0.0 0.00 1.0e+00 MAP2K5
Medication for cholesterol, blood pressure or diabetes 7.83 33 14 42.4 0.99 2.6e-26 ACE ATP2B1 C1GALT1 C4orf22 CHP1 CISD2 CLCN6 CSK CTC-228N24.3 CTD-3032J10.3 FCF1P2 FES FLJ13197 KIAA1199 LFNG MTHFR OPRL1 PDXK PLCB1 RGS19 RP11-588K22.2 SENP1 SH2B3 SIK2 SIPA1 SLC4A7 TCEA2 TMEM133 TNFRSF25 TSPY26P WNT2B YEATS4 ZBTB46
Gout (self-reported) 1.61 1 0 0.0 0.00 1.0e+00 SH2B3
Hypothyroidism/myxoedema (self-reported) 2.03 4 3 9.1 -0.19 8.1e-01 ADAM1A MSRA RP5-1115A15.1 SH2B3
Medication: Amlodipine 5.96 18 9 27.3 -0.96 3.7e-11 C6orf174 CD164L2 CLCN6 FES FLJ13197 KDM2B KIAA1199 MTHFR RNF34 RP4-635E18.7 SENP1 SENP3 SLC4A7 TMEM133 TMEM26 TNNT3 WNT2B ZNF318
Birth weight 2.05 6 6 18.2 0.94 5.8e-03 ADAM1A DCAF16 FES SH2B3 SIK2 TNNT3
High blood pressure (siblings) 4.62 10 4 12.1 -0.97 5.6e-06 ACP2 C1GALT1 CLCN6 FES NRBF2 PRELID1P1 SH2B3 TMEM133 TNNT3 VKORC1
Forced vital capacity (FVC), Best measure 1.78 10 5 15.2 0.75 1.2e-02 ACP2 CTC-228N24.3 DCAF16 GMEB2 HOXB2 MLLT10 PIAS4 RP11-538P18.2 SNAP47 VKORC1
Body fat percentage 2.36 27 11 33.3 -0.66 1.7e-04 CHP1 CLCN6 COX5A CTB-31O20.6 DBR1 DCAF16 HSD17B12 KDM2B KLC1 KLF16 MAP2K5 MLLT10 MSRA MYO9B NOC3L PIAS4 RNF34 RP11-810M2.2 RP5-1115A15.1 RPP25 SENP3 SIPA1 SLC5A11 STAG3L2 TEX15 TNFRSF25 VKORC1
Leg fat percentage (right) 2.71 26 14 42.4 -0.68 1.5e-04 CHP1 CLCN6 COX5A CTB-31O20.6 CTC-228N24.3 DCAF16 GTF2B HSD17B12 KDM2B KLC1 MAP2K5 MLLT10 MOBP MSRA NOC3L PIAS4 PKP4 RP11-810M2.2 RP5-1115A15.1 RPP25 SCAMP2 SLC5A11 STAG3L2 TEX15 TNFRSF25 VKORC1
Arm fat-free mass (right) 1.90 20 14 42.4 0.08 7.5e-01 DCAF16 EFR3B HSD17B12 KIAA1199 KLF16 MAP2K5 MARCH2 MLLT10 MSRA MYO9B NEIL2 PDE1A PRELID1P1 SENP3 SH2B3 SLC22A4 SLC5A11 ULK3 VKORC1 WDR66
Comparative body size at age 10 1.76 9 3 9.1 -0.40 2.9e-01 ATG7 CERS5 EFR3B FCF1P2 MAP2K5 MSRA VKORC1 ZNF318 ZNF652
Worry too long after embarrassment 1.51 2 2 6.1 0.00 1.0e+00 MSRA PCCB
Wheeze or whistling in the chest in last year 1.83 3 1 3.0 0.00 1.0e+00 GMEB2 SIK2 VKORC1
Age at first live birth 1.33 1 0 0.0 0.00 1.0e+00 DCAF16
Pulse wave peak to peak time 1.87 1 1 3.0 0.00 1.0e+00 ADAM1A
Qualifications: College or University degree 1.28 9 2 6.1 0.80 9.6e-03 DCAF16 GTF2B MED8 MLLT10 PKP4 SLC5A11 TEX15 TNFRSF25 VKORC1
Medication for pain relief, constipation, heartburn 1.75 3 0 0.0 0.00 1.0e+00 C20orf160 KIAA1199 YEATS4
Neck or shoulder pain in last month 1.27 1 0 0.0 0.00 1.0e+00 RP5-1115A15.1
Medication: Blood pressure 9.51 49 24 72.7 -0.99 1.1e-41 ACE ACP2 ADAM1A ATP2B1 C1GALT1 C20orf160 C4orf22 CCDC112 CEP41 CISD2 CLCN6 CSK CTC-228N24.3 CWF19L2 CYP11A1 DCAF16 EFR3B FCF1P2 FES FLJ13197 HOXB2 KDM2B KIAA1199 KLF16 LFNG MOBP MTHFR NELFCD NOC3L OPRL1 PDXK PLCB1 PRELID1P1 RNF34 RP11-463M16.4 RP11-810M2.2 RP4-635E18.7 SENP1 SENP3 SH2B3 SIK2 SLC4A7 TMEM133 TNNT3 TSPY26P ULK3 WDR66 WNT2B ZBTB46
Angina (self-reported) 2.98 5 1 3.0 -0.99 8.0e-04 FES OPRL1 RGS19 RP11-463M16.4 TCEA2
Migraine (self-reported) 1.26 1 0 0.0 0.00 1.0e+00 NT5C2
Medication: Allopurinol 1.76 3 1 3.0 0.00 1.0e+00 LSMD1 SH2B3 WDR66
Medication: Seretide 50 evohaler 1.37 1 1 3.0 0.00 1.0e+00 SLC22A4
Mean time to correctly identify matches 1.44 3 1 3.0 0.00 1.0e+00 PIAS4 RP11-810M2.2 SH2B3
Whole body fat mass 2.16 22 12 36.4 -0.62 2.1e-03 CLCN6 COX5A CTB-31O20.6 DBR1 HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLF16 MAP2K5 MLLT10 MSRA PIAS4 RP11-810M2.2 RP5-1115A15.1 RPP25 SLC5A11 STAG3L2 TDRD1 TEX15 TNFRSF25 VKORC1
Leg fat mass (right) 2.39 23 10 30.3 -0.63 1.2e-03 CLCN6 CTB-31O20.6 HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLF16 MAP2K5 MLLT10 MOBP MSRA PIAS4 RP11-810M2.2 RP5-1115A15.1 RPP25 SCAMP2 SLC5A11 STAG3L2 TEX15 TNFRSF25 TSPY26P ULK3 VKORC1
Arm predicted mass (right) 1.93 22 15 45.5 -0.02 9.3e-01 DCAF16 EFR3B HSD17B12 KIAA1199 KLF16 MAP2K5 MARCH2 MLLT10 MSRA MYO9B NEIL2 PDE1A PRELID1P1 SENP3 SH2B3 SLC22A4 SLC4A7 SLC5A11 TSPY26P ULK3 VKORC1 WDR66
Pulse rate, automated reading 1.24 5 0 0.0 -0.10 8.7e-01 ACP2 C4orf22 SIK2 STAG3L2 TMEM26
Alcohol intake frequency. 1.47 3 2 6.1 0.00 1.0e+00 STAG3L2 TEX15 VKORC1
Comparative height size at age 10 1.73 17 9 27.3 0.41 1.0e-01 DCAF16 GTF2B KIAA1199 KLC1 MED8 PDE1A PIAS4 PIGV PRELID1P1 RP11-810M2.2 RP4-635E18.7 RP5-1115A15.1 RYK SH2B3 SLC22A4 SNAP47 WDR66
Number of full sisters 1.44 1 0 0.0 0.00 1.0e+00 NRBF2
Suffer from 'nerves' 1.22 2 0 0.0 0.00 1.0e+00 MSRA RP5-1115A15.1
Overall health rating 2.43 12 4 12.1 -0.99 2.5e-09 C1GALT1 C20orf160 KLC1 MLLT10 MSRA SIPA1 SLC5A11 STAG3L2 TEX15 TNFRSF25 TSPY26P VKORC1
Chest pain or discomfort 1.42 1 0 0.0 0.00 1.0e+00 KB-1107E3.1
Medication: Aspirin 4.24 10 1 3.0 -0.97 3.8e-06 DCBLD1 FES GOPC OPRL1 RGS19 RP11-463M16.4 SH2B3 SIK2 TCEA2 VEGFB
Hypertension (Self-reported) 13.97 132 105 318.2 -1.00 4.1e-144 AC006111.1 ACE ACP2 ADAM1A ADRB2 AGT ARID3B ATG7 ATP2B1 C1GALT1 C20orf160 C4orf22 C6orf174 CCDC112 CD164L2 CDK10 CEP41 CERS5 CHP1 CISD2 CLCN6 COX5A CSK CTB-31O20.6 CTC-228N24.3 CTC-429P9.1 CTD-3032J10.3 CWF19L2 CYP11A1 DBR1 DCAF16 DCBLD1 EFR3B FBF1 FCF1P2 FES FLJ13197 GLTP GMEB2 GOPC GTF2B HOXB2 HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLC1 KLF16 KREMEN1 LFNG LINC00680 LSMD1 MAP2K5 MARCH2 MED8 MGRN1 MLLT10 MOBP MPI MSRA MTHFR MYO9B NDUFAF6 NEIL2 NELFCD NOC3L NRBF2 NSUN6 NT5C2 OPRL1 PCCB PDE1A PDXK PHIP PIAS4 PIGV PKP4 PLCB1 PRELID1P1 PRKD3 RGS19 RNF34 RP11-1055B8.4 RP11-463M16.4 RP11-538P18.2 RP11-588K22.2 RP11-810M2.2 RP1-197B17.3 RP4-635E18.7 RP4-758J18.10 RP5-1115A15.1 RP5-930J4.4 RP5-994D16.9 RPP25 RYK SCAMP2 SDAD1P1 SENP1 SENP3 SH2B3 SIK2 SIPA1 SLC22A4 SLC26A10 SLC4A7 SLC5A11 SNAP47 SNX16 STAG3L2 SWAP70 TBC1D19 TCEA2 TDRD1 TEX15 TMEM133 TMEM26 TNFRSF25 TNNT3 TSPY26P UBE2E3 UBL3 ULK3 USP37 VANGL1 VEGFB VKORC1 WDR66 WNT2B YEATS4 ZBTB46 ZNF318 ZNF652
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.18 1 0 0.0 0.00 1.0e+00 KDM2B
Illnesses of father: Heart disease 2.08 1 1 3.0 0.00 1.0e+00 FES
Smoking status: Previous 1.44 2 0 0.0 0.00 1.0e+00 MAP2K5 SH2B3
Forced expiratory volume in 1-second (FEV1), predicted 1.50 3 2 6.1 0.00 1.0e+00 DCAF16 MGRN1 SLC22A4
Whole body fat-free mass 1.89 23 15 45.5 0.10 6.6e-01 CCDC112 CTC-228N24.3 DCAF16 EFR3B HSD17B12 KIAA1199 KLF16 MAP2K5 MARCH2 MSRA MYO9B NEIL2 NT5C2 PDE1A PRELID1P1 SENP3 SH2B3 SLC22A4 SLC4A7 SLC5A11 ULK3 VKORC1 WDR66
Leg fat-free mass (right) 1.89 21 14 42.4 0.28 2.3e-01 CTC-228N24.3 DCAF16 FES HSD17B12 KIAA1199 KLF16 MAP2K5 MSRA MYO9B NEIL2 NT5C2 PDE1A PRELID1P1 SH2B3 SLC22A4 SLC5A11 TDRD1 TMEM133 ULK3 VKORC1 WDR66
Arm fat percentage (left) 2.32 25 15 45.5 -0.70 1.1e-04 CHP1 CLCN6 COX5A CTB-31O20.6 DCAF16 FBF1 HSD17B12 KDM2B KLC1 KLF16 MAP2K5 MLLT10 MSRA PIAS4 RNF34 RP11-810M2.2 RP5-1115A15.1 RPP25 SENP3 SIPA1 SLC5A11 STAG3L2 TEX15 TNFRSF25 VKORC1
Average weekly red wine intake 1.54 1 0 0.0 0.00 1.0e+00 MPI
Mood swings 1.18 3 1 3.0 0.00 1.0e+00 ACP2 MSRA SLC5A11
Loneliness, isolation 1.27 2 0 0.0 0.00 1.0e+00 RP5-1115A15.1 SH2B3
Long-standing illness, disability or infirmity 2.04 4 0 0.0 -0.99 5.5e-03 CHP1 DBR1 KLC1 STAG3L2
Ever had bowel cancer screening 1.16 1 0 0.0 0.00 1.0e+00 SIK2
Diabetes diagnosed by doctor 2.43 3 1 3.0 0.00 1.0e+00 ACE DBR1 ZBTB46
Medication for cholesterol 6.53 25 6 18.2 0.97 2.3e-15 ACE AGT ATG7 C4orf22 C6orf174 CDK10 CISD2 FES KIAA1199 MGRN1 OPRL1 PIGV PLCB1 PRELID1P1 PRKD3 RGS19 SENP1 SH2B3 TCEA2 TMEM133 TNNT3 VEGFB VKORC1 WNT2B ZBTB46
Back pain experienced in last month 1.43 1 0 0.0 0.00 1.0e+00 WDR66
Mineral and other dietary supplements 1.15 1 0 0.0 0.00 1.0e+00 NRBF2
Breast cancer (self-reported) 1.40 1 1 3.0 0.00 1.0e+00 SLC4A7
Asthma (self-reported) 1.62 5 4 12.1 -0.27 6.6e-01 FBF1 RP5-1115A15.1 SIK2 SLC22A4 ZNF652
Osteoarthritis (self-reported) 1.76 2 0 0.0 0.00 1.0e+00 COX5A RPP25
Medication: Aspirin 4.34 7 1 3.0 -0.97 3.2e-04 DCBLD1 FES OPRL1 RGS19 RP11-463M16.4 SIK2 VEGFB
Medication: Gliclazide 1.52 1 0 0.0 0.00 1.0e+00 DBR1
Illnesses of father: None of the above (group 1) 2.51 2 1 3.0 0.00 1.0e+00 FES SH2B3
Smoking status: Current 1.45 1 0 0.0 0.00 1.0e+00 MSRA
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.55 4 1 3.0 0.22 7.8e-01 MSRA NRBF2 RP11-538P18.2 VKORC1
Whole body water mass 1.90 25 15 45.5 0.15 4.9e-01 CCDC112 CTC-228N24.3 CTD-3032J10.3 DCAF16 EFR3B HSD17B12 KIAA1199 KLF16 MAP2K5 MARCH2 MSRA MYO9B NEIL2 NT5C2 PDE1A PRELID1P1 SENP3 SH2B3 SLC22A4 SLC4A7 SLC5A11 TMEM133 ULK3 VKORC1 WDR66
Leg predicted mass (right) 1.88 21 14 42.4 0.28 2.3e-01 CTC-228N24.3 DCAF16 FES HSD17B12 KIAA1199 KLF16 MAP2K5 MSRA MYO9B NEIL2 NT5C2 PDE1A PRELID1P1 SH2B3 SLC22A4 SLC5A11 TDRD1 TMEM133 ULK3 VKORC1 WDR66
Arm fat mass (left) 2.21 23 10 30.3 -0.71 1.7e-04 CLCN6 COX5A CTB-31O20.6 EFR3B HSD17B12 KDM2B KIAA1199 KLC1 KLF16 MAP2K5 MLLT10 MSRA PIAS4 RP11-810M2.2 RP5-1115A15.1 RPP25 SIPA1 SLC5A11 STAG3L2 TDRD1 TEX15 TNFRSF25 VKORC1
Number of self-reported non-cancer illnesses 4.87 16 3 9.1 -0.98 5.9e-12 CISD2 GMEB2 KDM2B KLC1 LSMD1 MLLT10 MYO9B OPRL1 RGS19 RP5-930J4.4 SH2B3 SLC22A4 STAG3L2 TCEA2 ZNF318 ZNF652
Miserableness 1.16 3 1 3.0 0.00 1.0e+00 ACP2 MSRA RP5-1115A15.1
Guilty feelings 1.01 2 0 0.0 0.00 1.0e+00 MSRA NEIL2
Financial situation satisfaction 1.16 1 0 0.0 0.00 1.0e+00 ULK3
Eye problems/disorders: Glaucoma 1.31 1 0 0.0 0.00 1.0e+00 TEX15
Medication: Blood pressure 10.45 74 31 93.9 -0.99 8.6e-60 AC006111.1 ACE ACP2 ADRB2 AGT ARID3B ATG7 ATP2B1 C1GALT1 C4orf22 C6orf174 CDK10 CERS5 CHP1 CISD2 CLCN6 COX5A CSK CTB-31O20.6 CTD-3032J10.3 CWF19L2 CYP11A1 DBR1 FCF1P2 FES GMEB2 GTF2B KB-1107E3.1 KDM2B KIAA1199 LFNG LSMD1 MGRN1 MPI MSRA MTHFR MYO9B NEIL2 NRBF2 NSUN6 NT5C2 OPRL1 PCCB PDXK PIGV PLCB1 PRELID1P1 PRKD3 RGS19 RNF34 RP11-1055B8.4 RP11-588K22.2 RP11-810M2.2 RP4-635E18.7 RPP25 SCAMP2 SENP3 SH2B3 SIK2 SIPA1 SLC22A4 SLC4A7 TBC1D19 TCEA2 TDRD1 TEX15 TMEM133 TNNT3 UBL3 ULK3 VEGFB WNT2B ZBTB46 ZNF318
High cholesterol (Self-reported) 3.27 10 5 15.2 -0.94 7.1e-05 CWF19L2 DCAF16 FBF1 OPRL1 PIGV RGS19 TCEA2 TMEM133 VEGFB VKORC1
Medication: Bendroflumethiazide 7.06 28 8 24.2 -0.97 1.6e-18 ACP2 ATP2B1 C6orf174 CCDC112 CD164L2 CDK10 CSK FES KIAA1199 MGRN1 MSRA MYO9B NEIL2 NRBF2 PIGV PLCB1 PRELID1P1 RP11-463M16.4 SENP3 SH2B3 SLC22A4 SLC4A7 TEX15 TMEM133 TNNT3 USP37 VKORC1 WNT2B
Medication: Paracetamol 1.67 1 0 0.0 0.00 1.0e+00 MLLT10
Medication: Lisinopril 4.20 5 0 0.0 -0.98 4.0e-03 ACP2 CSK FCF1P2 NRBF2 TMEM133
Medication: Atorvastatin 2.01 1 0 0.0 0.00 1.0e+00 VKORC1
Illnesses of father: High blood pressure 3.93 6 1 3.0 -0.98 4.5e-04 ACE ACP2 C4orf22 CLCN6 FES PLCB1
Ever smoked 1.28 2 0 0.0 0.00 1.0e+00 MAP2K5 SH2B3
Basal metabolic rate 1.88 22 14 42.4 0.04 8.6e-01 CCDC112 CTC-228N24.3 DCAF16 EFR3B HSD17B12 KIAA1199 KLF16 MAP2K5 MARCH2 MLLT10 MSRA NEIL2 NT5C2 PDE1A PRELID1P1 SH2B3 SLC22A4 SLC5A11 TDRD1 ULK3 VKORC1 WDR66
Leg fat percentage (left) 2.75 28 14 42.4 -0.69 4.8e-05 CHP1 CLCN6 COX5A CTB-31O20.6 CTC-228N24.3 DCAF16 GTF2B HSD17B12 KDM2B KLC1 MAP2K5 MLLT10 MOBP MSRA NOC3L PIAS4 PKP4 RP11-810M2.2 RP5-1115A15.1 RPP25 SCAMP2 SIPA1 SLC5A11 STAG3L2 TEX15 TNFRSF25 TSPY26P VKORC1
Arm fat-free mass (left) 1.89 22 14 42.4 -0.08 7.1e-01 DCAF16 EFR3B HSD17B12 KIAA1199 KLF16 MAP2K5 MARCH2 MLLT10 MSRA NEIL2 PDE1A PRELID1P1 RP11-810M2.2 SENP3 SH2B3 SLC22A4 SLC4A7 SLC5A11 TSPY26P ULK3 VKORC1 WDR66
Number of operations (self-reported) 1.65 1 0 0.0 0.00 1.0e+00 MLLT10
Average weekly beer plus cider intake 1.32 1 0 0.0 0.00 1.0e+00 CCDC112
Irritability 1.18 2 2 6.1 0.00 1.0e+00 MSRA NEIL2
Risk taking 1.39 3 1 3.0 0.00 1.0e+00 KLC1 MSRA PCCB
Diastolic blood pressure, automated reading 8.19 67 45 136.4 -0.97 8.0e-44 AC006111.1 ACP2 ADAM1A AGT ATP2B1 C1GALT1 C20orf160 C4orf22 C6orf174 CCDC112 CEP41 CERS5 CHP1 CLCN6 COX5A CSK CTB-31O20.6 CTD-3032J10.3 CWF19L2 CYP11A1 DBR1 DCAF16 FCF1P2 FES GLTP GMEB2 KIAA1199 LFNG LSMD1 MAP2K5 MED8 MGRN1 MLLT10 MPI MSRA MTHFR MYO9B NDUFAF6 NEIL2 NELFCD NOC3L NRBF2 NSUN6 NT5C2 PDE1A PHIP PIGV PRELID1P1 RP11-463M16.4 RP11-538P18.2 RP5-1115A15.1 RPP25 RYK SENP3 SH2B3 SIPA1 SLC5A11 STAG3L2 SWAP70 TCEA2 TMEM133 TMEM26 TNNT3 TSPY26P ULK3 VKORC1 WNT2B
Unable to work because of sickness or disability 1.34 1 0 0.0 0.00 1.0e+00 MED8
Cholesterol lowering medication 3.21 9 3 9.1 -0.99 9.5e-07 DCAF16 MGRN1 OPRL1 PIGV RGS19 RNF34 TCEA2 VEGFB VKORC1
Basal cell carcinoma (self-reported) 1.19 1 1 3.0 0.00 1.0e+00 CDK10
Heart attack/myocardial infarction (self-reported) 2.80 2 1 3.0 0.00 1.0e+00 FES SH2B3
Heart disease (siblings) 1.75 1 0 0.0 0.00 1.0e+00 FES
Pack years of smoking 1.33 2 0 0.0 0.00 1.0e+00 KLC1 PIAS4
Impedance of whole body 2.18 32 20 60.6 0.13 4.7e-01 ATG7 CEP41 CERS5 CISD2 CTB-31O20.6 CTC-228N24.3 CTD-3032J10.3 CYP11A1 HSD17B12 KIAA1199 KLF16 MAP2K5 MARCH2 MSRA MYO9B NEIL2 NOC3L NT5C2 PDE1A PRKD3 RP11-463M16.4 RP4-758J18.10 RYK SENP1 SENP3 SLC4A7 STAG3L2 SWAP70 ULK3 USP37 VKORC1 ZNF652
Leg fat mass (left) 2.41 25 13 39.4 -0.58 2.4e-03 CLCN6 COX5A CTB-31O20.6 HSD17B12 KB-1107E3.1 KDM2B KIAA1199 KLF16 MAP2K5 MLLT10 MOBP MSRA PIAS4 RP11-810M2.2 RP5-1115A15.1 RPP25 SCAMP2 SLC5A11 STAG3L2 TDRD1 TEX15 TNFRSF25 TSPY26P ULK3 VKORC1
Arm predicted mass (left) 1.91 21 13 39.4 -0.07 7.6e-01 DCAF16 EFR3B HSD17B12 KIAA1199 KLF16 MAP2K5 MARCH2 MLLT10 MSRA NEIL2 PDE1A PRELID1P1 RP11-810M2.2 SENP3 SH2B3 SLC22A4 SLC4A7 SLC5A11 ULK3 VKORC1 WDR66

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 29 0.831 2.88
GTEx Adipose Visceral Omentum 18 0.884 2.90
GTEx Adrenal Gland 14 0.961 2.85
GTEx Artery Aorta 37 1.243 3.03
GTEx Artery Coronary 8 0.676 2.83
GTEx Artery Tibial 38 1.010 2.93
GTEx Brain Caudate basal ganglia 3 0.326 2.76
GTEx Brain Cerebellar Hemisphere 19 1.276 2.86
GTEx Brain Cerebellum 17 0.858 3.00
GTEx Brain Cortex 7 0.676 3.00
GTEx Brain Frontal Cortex BA9 12 1.299 3.00
GTEx Brain Hippocampus 4 0.763 2.80
GTEx Brain Hypothalamus 4 0.678 2.57
GTEx Brain Nucleus accumbens basal ganglia 6 0.694 2.86
GTEx Brain Putamen basal ganglia 4 0.641 2.60
GTEx Breast Mammary Tissue 16 0.811 2.81
GTEx Breast Mammary Tissue (Male) 15 1.257 2.78
GTEx Breast Mammary Tissue (Female) 14 0.852 2.75
GTEx Cells EBV-transformed lymphocytes 6 0.422 2.78
GTEx Cells Transformed fibroblasts 38 0.905 2.82
GTEx Colon Sigmoid 14 0.958 2.78
GTEx Colon Transverse 18 0.872 2.82
GTEx Esophagus Gastroesophageal Junction 15 1.038 2.91
GTEx Esophagus Mucosa 34 1.024 2.84
GTEx Esophagus Muscularis 31 0.959 2.84
GTEx Heart Atrial Appendage 14 0.887 2.80
GTEx Heart Left Ventricle 15 0.980 2.86
GTEx Liver 5 0.697 2.62
GTEx Lung 27 0.940 2.90
GTEx Muscle Skeletal 25 0.865 2.88
GTEx Nerve Tibial 36 0.833 2.72
GTEx Ovary 12 1.322 3.18
GTEx Pancreas 13 0.797 2.88
GTEx Pituitary 9 0.807 2.87
GTEx Prostate 13 1.557 3.10
GTEx Skin Not Sun Exposed Suprapubic 26 1.057 2.92
GTEx Skin Sun Exposed Lower leg 34 0.934 2.87
GTEx Small Intestine Terminal Ileum 6 1.302 2.94
GTEx Spleen 9 0.638 2.78
GTEx Stomach 19 1.307 3.06
GTEx Testis 28 0.887 2.84
GTEx Thyroid 38 0.950 2.84
GTEx Uterus 7 1.235 2.81
GTEx Vagina 6 0.945 2.85
GTEx Whole Blood 18 0.903 2.75
METSIM Adipose 23 0.499 2.52
NTR Blood 16 0.666 2.70
ROSMAP Brain Pre-frontal Cortex 44 1.002 2.89
YFS Blood 30 0.650 2.54
CommonMind Brain Pre-frontal Cortex 45 0.837 2.63
TCGA Breast Tumor 9 1.173 2.98
TCGA Breast Normal 19 0.452 2.51
TCGA Ovarian Tumor 14 0.479 2.36
TCGA Prostate Tumor 22 0.636 2.62